DOUBLETWIST INC
S-1/A, EX-4.1, 2000-10-13
BUSINESS SERVICES, NEC
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<PAGE>

                                                                   Exhibit 4.1

[GRAPHIC]               [DOUBLETWIST LOGO]                           [GRAPHIC]
           INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE

COMMON STOCK                                                 CUSIP 258627 10 8
                                           SEE REVERSE FOR CERTAIN DEFINITIONS

THIS CERITIFIES THAT



IS THE OWNER OF

    FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK, $0.01 PAR VALUE PER
SHARE, OF

                         DOUBLETWIST, INC.

transferable on the books of the Corporation in person or by duly authorized
attorney upon surrender of the Certificate properly endorsed. This
Certificate is not valid until countersigned by the Transfer Agent and
registered by the Registrar.
   Witness the facsimile seal of the Corporation and the facsimile signatures
of its duly authorized officers.

DATED:    [SIGNATURE]       [CORPORATE SEAL]        [SIGNATURE]
           SECRETARY                           PRESIDENT AND CHIEF
                                                EXECUTIVE OFFICER

COUNTERSIGNED AND REGISTERED:
  COMPUTERSHARE INVESTOR SERVICES, LLC

                         TRANSFER AGENT
                         AND REGISTRAR,

By

                   Authorized Signature

<PAGE>

                     DOUBLETWIST, INC.

     The following abbreviations, when used in the inscription on the face of
this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

TEN COM - as tenants in common
TEN ENT - as tenants by the entireties
JT TEN  - as joint tenants with right of
          survivorship and not as tenants
          in common

UNIF GIFT MIN ACT - ................ Custodian ..................
                    (Cust)                                (Minor)
                    under Uniform Gifts to Minors
                    Act .........................................
                                       (State)

UNIF TRF MIN ACT - ......... Custodian (until age ..........)
                   (Cust)
                   .................under Uniform Transfers
                         (Minor)
                   to Minors Act ................................
                                       (State)

Additional abbreviations may also be used though not in the above list.

For Value received,                 hereby sell, assign and transfer unto
                   -----------------
PLEASE INSERT SOCIAL SECURITY OR OTHER
IDENTIFYING NUMBER OF ASSIGNEE

-------------------------
/                        /
-------------------------

-----------------------------------------------------------------------------
PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF
ASSIGNEE

-----------------------------------------------------------------------------

-----------------------------------------------------------------------------

---------------------------------------------------------------------- Shares

of the Common Stock represented by the within Certificate, and do(es) hereby
irrevocably constitute and appoint

-------------------------------------------------------------------- Attorney

to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.

Dated
     -----------------------------

                                       X -----------------------------

                                       X -----------------------------

          NOTICE:  THE SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND
                   WITH THE NAME(S) AS WRITTEN UPON THE FACE OF THE
                   CERTIFICATE IN EVERY PARTICULAR WITHOUT ALTERATION OR
                   ENLARGEMENT OR ANY CHANGE WHATEVER.

Signature(s) Guaranteed:


By
   -------------------------------------------
THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION
(BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO
S.E.C. RULE 17Ad-15.



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