MOLECULAR DIAGNOSTICS & THERAPEUTICS INC
SB-2/A, 2000-05-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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As filed with the Securities and Exchange Commission on May 9, 2000


                                              Registration No. 333-33662

================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM SB-2
                                Amendment No. 2
                             Registration Statement
                                    Under The
                             Securities Act of 1933


                   MOLECULAR DIAGNOSTICS & THERAPEUTICS, INC.
                 (Name of Small Business Issuer in its Charter)

                                    Colorado
                        ---------------------------------
                          (State or Other Jurisdiction
                        of Incorporation or Organization)

                                      2835
                          ----------------------------
                          (Primary Standard Industrial
                           Classification Code Number)

                                   84-1191749
                               -------------------
                                (I.R.S. Employer
                               Identification No.)

                        1880 Industrial Circle, Suite B-3
                            Longmont, Colorado 80501
                                 (303) 485-8500
          -------------------------------------------------------------
          (Address and Telephone Number of Principal Executive Offices)

                        1880 Industrial Circle, Suite B-3
                            Longmont, Colorado 80501
                   -------------------------------------------
                   (Address and Principal Place of Business or
                      Intended Principal Place of Business)

                                Malcolm H. Benedict
                               2595 Canyon Blvd.,
                                   Suite 160
                               Boulder, CO 80302
                                 (303) 485-8500
            ---------------------------------------------------------
            (Name, Address and Telephone Number of Agent for Service)

                                    Copy to:
                                Arnold R. Kaplan
            Reinhart, Boerner, Van Deuren, Norris & Rieselbach, P.C.
                         1775 Sherman Street, Suite 2100
                             Denver, Colorado 80203
                                 (303) 831-0909

                Approximate Date of Proposed Sale to the Public:
   As soon as practicable after this Registration Statement becomes effective.

<PAGE>

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering. [ ]

         If this  Form is a  post-effective  amendment  filed  pursuant  to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering. [ ]

         If this  Form is a  post-effective  amendment  filed  pursuant  to Rule
462(d) under the Securities Act, check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering. [ ]

         If delivery of the  prospectus  is expected to be made pursuant to Rule
434, check the following box. [ ]

    ------------------------------------------------------------------------

<TABLE>
<CAPTION>

                         CALCULATION OF REGISTRATION FEE

 =====================================================================================================================

                                                            Proposed Maximum       Proposed Maximum       Amount of
Title Each Class of Securities           Amount To Be            Offering              Aggregate        Registration
      To Be Registered                    Registered        Price per share(1)      Offering Price           Fee
- ----------------------------------------------------------------------------------------------------------------------
<S>                                        <C>                     <C>                <C>                   <C>
Common Stock, $.01 par value               1,000,000               $10.00             $10,000,000           $2780
- ----------------------------------------------------------------------------------------------------------------------
Representative's Warrants to purchase         66,667               $.0001             $      6.67              --
Common Stock
- ----------------------------------------------------------------------------------------------------------------------
Common Stock, $.01 par value,                 66,667               $10.00             $   666,670           $ 185
issuable upon Exercise of
Representative's Warrants(1)
- ----------------------------------------------------------------------------------------------------------------------
                                                      Total.................................................$2965
- ----------------------------------------------------------------------------------------------------------------------
</TABLE>

(1)      Estimated solely for purposes of calculating the registration fee.

        The Registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further  amendment  which  specifically  states  that  this  Registration
Statement shall  thereafter  become effective in accordance with Section 8(a) of
the Securities  Act of 1933 or until this  Registration  Statement  shall become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.


<PAGE>


                                     PART II

                     Information Not Required in Prospectus

Item 24.  Indemnification of Directors and Officers.

         The Registrant's Amended and Restated Articles of Incorporation provide
that the Board of Directors of the  Registrant  may indemnify any person who was
or is  threatened  to be made a party to any  threatened,  pending or  completed
action,  suit  or  proceeding,   whether  civil,  criminal,   administrative  or
investigative  (other than an action by or in the right of the  Registrant),  by
reason of the fact that he is or was a director,  officer,  employee or agent of
the  Registrant  or is or was  serving  at the  request of the  Registrant  as a
director, officer, employee or agent of another corporation,  partnership, joint
venture, trust or other enterprise,  against expenses (including attorney fees),
judgements,  fines  and  amounts  paid in  settlement  actually  and  reasonably
incurred by him in connection  with such action,  suit or proceeding if he acted
in good faith and in a manner he reasonably believed to be in the best interests
of the Registrant and, with respect to any criminal action or proceeding, had no
reasonable cause to be believe his conduct was unlawful.  The Board of Directors
may also indemnify any such person made a party to such actions and suits, by or
in the right of the  Registrant  to procure a  judgement  in its favor,  against
expenses  (including  attorney fees) actually in connection  with the defense or
settlement of such action or suit if he so acted, but no  indemnification  shall
be made in  respect of any  claim,  issue or matter as to which such  person has
been adjudged to be liable for  negligence or misconduct in the  performance  of
his  duty to the  registrant  unless  and  only to the  extent  that  the  court
determines,  in view of all of the  circumstances  of the case,  such  person is
fairly and reasonably entitled to such indemnification.

         The Registrant's Bylaws provide that the Registrant shall indemnify any
and all of its directors or officers,  or former  directors or officers,  or any
person who may have served at the Registrant's  request as a director or officer
of another corporation in which the Registrant owns capital stock or of which it
is a creditor,  against  expenses  actually and necessarily  incurred by them in
connection with the defense of any action,  suit or proceeding in which they, or
any of them,  are made  parties,  or a party,  by reason of being or having been
directors  or officers or a director  or officer of the  Registrant,  or of such
other  corporation,  except in relation to matters as to which any such director
or officer or former  director or person shall be adjudged in such action,  suit
or proceeding to be liable for  negligence or misconduct in the  performance  of
duty.

         The Colorado  Business  Corporation Act provides that a corporation may
indemnify a person made a party to a  proceeding  because the person is or was a
director  against  liability  incurred  in  the  proceeding  if (a)  the  person
conducted himself or herself in good faith, (b) the person  reasonably  believed
(1) in the case of conduct in an official  capacity with the  corporation,  that
his or her conduct was in the corporation's best interests; and (2) in all other
cases,  that his or her conduct  was at least not  opposed to the  corporation's
best interests and (c) in the case of any criminal proceeding, the person had no
reasonable   cause  to  believe   his  or  her  conduct   was   unlawful.   Such
indemnification  is permitted in connection with a proceeding by or in the right
of the  corporation  only to the  extent  of  reasonable  expenses  incurred  in
connection with the  proceeding.  A corporation may not indemnify a director (a)
in connection  with a proceeding by or in the right of the  corporation in which
the director was adjudged liable to the  corporation;  or (b) in connection with
any other  proceeding  charging that the director  derived an improper  personal
benefit,  whether or not  involving  action in an  official  capacity,  in which
proceeding the director was adjudged  liable on the basis that he or she derived
an improper personal benefit.

<PAGE>

         The  Colorado   Business   Corporation  Act  further  provides  that  a
corporation, unless limited by its articles of incorporation,  shall indemnify a
person who was wholly successful,  on the merits or otherwise, in the defense of
any  proceeding  to which the person was a party  because the person is or was a
director,  against reasonable expenses incurred by him or her in connection with
the proceeding.

         The  Registrant  has applied for  directors'  and  officers'  liability
insurance with an aggregate policy limit of $1,000,000.

Item 25.  Other Expenses of Issuance and Distribution.

         The estimated  expenses of this Offering,  all of which will be paid by
Registrant, are as follows:

SEC Registration Fee                                               $   2,965
National Association of Securities Dealers, Inc. Fee                   1,500
Nasdaq Listing Fee                                                     6,000
Accounting Fees and Expenses                                          15,000
Registrant's Legal Fees and Expenses                                 145,000
Blue Sky Expenses and Counsel Fees                                    17,000
Printing and Engraving Fees                                            3,500
Transfer Agent and Registrar's Fees and Expenses                       1,000
Miscellaneous Expenses                                                25,000
                                                                   ---------
         Total                                                     $ 217,065
                                                                   =========



<PAGE>



Item 26.  Recent Sales of Unregistered Securities.

         From January 1996 through June 1996, the  Registrant  sold an aggregate
of 40,500  shares of its Class D Preferred  Stock in a private  placement  to 27
investors  for an aggregate  consideration  of $202,500  ($5.00 per share).  The
offering was conducted in accordance with Rule 504 of Regulation D by means of a
confidential  offering memorandum.  Each share of Preferred stock was converted,
pursuant to its terms,  into twelve shares of the  Registrant's  common stock in
June, 1996 at the option of the Registrant for no additional consideration.(2)

         From July 1996 through  January 1997, the Registrant  sold an aggregate
of 12,835  shares of its Class E Preferred  Stock in a private  placement  to 15
investors  for an  aggregate  consideration  of $77,010  ($6.00 per share).  The
offering was conducted in accordance with Rule 504 of Regulation D by means of a
confidential  offering memorandum.  Each share of Preferred stock was converted,
pursuant to its terms,  into twelve shares of the  Registrant's  common stock in
January,   1997   at  the   option   of  the   Registrant   for  no   additional
consideration.(2)

         From  February  1997,  through  August,  1997  the  Registrant  sold an
aggregate of 20,500 shares of its Class F Preferred Stock in a private placement
to 11 investors for an aggregate  consideration  of $123,000  ($6.00 per share).
The offering was conducted in accordance  with Rule 504 of Regulation D by means
of a  confidential  offering  memorandum.  Each  share of  Preferred  stock  was
converted,  pursuant to its terms, into twelve shares of the Registrant's common
stock  in  August,  1997  at the  option  of the  Registrant  for no  additional
consideration.(2)

         From August,  1997 through March, 1998 the Registrant sold an aggregate
of 68,351  shares of its Class G Preferred  Stock in a private  placement  to 40
investors  for an aggregate  consideration  of $410,106  ($6.00 per share).  The
offering was conducted in accordance with Rule 504 of Regulation D by means of a
confidential  offering memorandum.  Each share of Preferred stock was converted,
pursuant to its terms,  into twelve shares of the  Registrant's  common stock in
March, 1998 at the option of the Registrant for no additional consideration.(2)

         In January,  1998 the  Registrant  issued  13,133  shares of its common
stock to an  individual  as a  consulting  fee for the  review  of the  offering
documents.  The shares  were  valued at the time of  issuance at $.50 per share.
Such individual was provided with access to all material  information  regarding
an investment in the Registrant  and was given the  opportunity to ask questions
of  and  receive  answers  from  the  executive   officers  of  the  Registrant.
Accordingly, this issuance was exempt from registration under the Securities Act
pursuant to Section 4(2) thereunder.(1)

<PAGE>

         From June 1998, through December 1998, the Registrant sold an aggregate
of 60,499  shares of its Class H Preferred  Stock in a private  placement  to 39
investors  for an aggregate  consideration  of $362,994  ($6.00 per share).  The
offering was conducted in accordance with Rule 504 of Regulation D by means of a
confidential  offering memorandum.  Each share of Preferred stock was converted,
pursuant to its terms,  into eight  shares of the  Registrant's  common stock in
December,   1998  at  the   option   of  the   Registrant   for  no   additional
consideration.(2)

         In August, 1998 the Registrant issued 600 shares of its common stock to
a shareholder  as a consulting  fee for the review of marketing  documents.  The
shares were valued at the time of  issuance at $.75 per share.  Such  individual
was provided with access to all material information  regarding an investment in
the  Registrant  and was given the  opportunity  to ask questions of and receive
answers  from  the  executive  officers  of the  Registrant.  Accordingly,  this
issuance  was exempt from  registration  under the  Securities  Act  pursuant to
Section 4(2) thereunder.(1)

         In January,  1999 the  Registrant  issued  10,000  shares of its common
stock to an  individual  as  compensation  for the  review  and  preparation  of
offering  documents.  The shares were valued at the time of issuance at $.75 per
share.  Such  individual  was provided  with access to all material  information
regarding an investment in the Registrant  and was given the  opportunity to ask
questions of and receive answers from the executive  officers of the Registrant.
Accordingly, this issuance was exempt from registration under the Securities Act
pursuant to Section 4(2) thereunder.(1)

         From February 1999 through July,  1999 the Registrant sold an aggregate
of 57,333  shares of its Class I Preferred  Stock in a private  placement  to 29
investors  for an aggregate  consideration  of $343,998  ($6.00 per share).  The
offering was conducted in accordance with Rule 504 of Regulation D by means of a
confidential  offering memorandum.  Each share of Preferred stock was converted,
pursuant to its terms,  into eight  shares of the  Registrant's  common stock in
July, 1999 at the option of the Registrant for no additional consideration.(2)

         In February,  1999 the  Registrant  issued  91,600 shares of its common
stock to an entity for  services  provided  to the  Registrant.  The shares were
valued at the time of  issuance  at $.75 per  share.  A  representative  of such
entity  was  provided  with  access to all  material  information  regarding  an
investment in the Registrant  and was given the  opportunity to ask questions of
and receive answers from the executive officers of the Registrant.  Accordingly,
this issuance was exempt from registration  under the Securities Act pursuant to
Section 4(2) thereunder.(1)

<PAGE>

         In March,  1999 the Registrant  issued 1,000 shares of its common stock
to an individual as a consulting fee for the review of financial documents.  The
shares were valued at the time of  issuance at $.75 per share.  Such  individual
was provided with access to all material information  regarding an investment in
the  Registrant  and was given the  opportunity  to ask questions of and receive
answers  from  the  executive  officers  of the  Registrant.  Accordingly,  this
issuance  was exempt from  registration  under the  Securities  Act  pursuant to
Section 4(2) thereunder.(1)

         In March,  1999 the Registrant  issued 3,500 shares of its common stock
to an employee of the Registrant as a bonus.  The shares were valued at the time
of issuance at $.75 per share.  Such  employee was  provided  with access to all
material information regarding an investment in the Registrant and was given the
opportunity to ask questions of and receive answers from the executive  officers
of the Registrant. Accordingly, this issuance was exempt from registration under
the Securities Act pursuant to Section 4(2) thereunder.(1)

         In March, 1999 the Registrant issued 100,000 shares of its common stock
to a director of the  Registrant for his services to the Registrant as director.
The shares were valued at the time of issuance at $.75 per share.  The  director
had  access  to  all  material  information   regarding  an  investment  in  the
Registrant.  Accordingly,  this issuance was exempt from registration  under the
Securities Act pursuant to Section 4(2) thereunder.(1)

         In March,  1999 the Registrant issued 86,300 shares of its common stock
to an officer of the  Registrant  for accrued  services to the  Registrant as an
officer.  The shares were valued at the time of issuance at $.75 per share.  The
officer had access to all material  information  regarding an  investment in the
Registrant.  Accordingly,  this issuance was exempt from registration  under the
Securities Act pursuant to Section 4(2) thereunder.(1)

         In March,  1999 the Registrant  issued 1,600 shares of its common stock
to an individual as a consulting fee for reviewing  documents in connection with
the G preferred offering. The shares were valued at the time of issuance at $.75
per share. Such individual was provided with access to all material  information
regarding an investment in the Registrant  and was given the  opportunity to ask
questions of and receive answers from the executive  officers of the Registrant.
Accordingly, this issuance was exempt from registration under the Securities Act
pursuant to Section 4(2) thereunder.(1)

         In April,  1999 the Registrant  issued an aggregate of 35,000 shares of
its common stock to seven individuals (5,000 shares each) for their agreement to
serve on the Registrant's  Scientific  Advisory Board. The shares were valued at
the time of issuance at $.75 per share.  Each of the  individuals  was  provided
with  access  to  all  material  information  regarding  an  investment  in  the
Registrant and was given the opportunity to ask questions of and receive answers
from the executive officers of the Registrant. Accordingly, these issuances were
exempt from  registration  under the  Securities  Act  pursuant to Section  4(2)
thereunder.(1)

<PAGE>

         In May, 1999 the Registrant  issued 6,667 shares of its common stock to
an individual for services provided to the Registrant. The shares were valued at
the time of issuance at $.75 per share. Such individual was provided with access
to all material  information  regarding an investment in the  Registrant and was
given the opportunity to ask questions of and receive answers from the executive
officers  of  the  Registrant.   Accordingly,  this  issuance  was  exempt  from
registration under the Securities Act pursuant to Section 4(2) thereunder.(1)

         In July,  1999 the Registrant  issued 800 shares of its common stock to
an individual as a consulting fee for reviewing  documents in connection  with H
preferred  offering.  The shares were valued at the time of issuance at $.75 per
share.  Such  individual  was provided  with access to all material  information
regarding an investment in the Registrant  and was given the  opportunity to ask
questions of and receive answers from the executive  officers of the Registrant.
Accordingly, this issuance was exempt from registration under the Securities Act
pursuant to Section 4(2) thereunder.(1)

         In July,  1999 the Registrant  issued 10,000 shares of its common stock
to the  Registrant's  corporate  secretary  for her services as  secretary.  The
shares were valued at the time of issuance at $.75 per share.  She had access to
all material information regarding an investment in the Registrant. Accordingly,
this issuance was exempt from registration  under the Securities Act pursuant to
Section 4(2) thereunder.(1)

         In July,  1999 the Registrant  issued 33,933 shares of its common stock
to an officer of the  Registrant  as  employment  compensation.  The shares were
valued at the time of issuance at $.75 per share.  The  individual had access to
all material information regarding an investment in the Registrant. Accordingly,
the issuance was exempt from  registration  under the Securities Act pursuant to
Section 4(2) thereunder.(1)

         In July, 1999 the Registrant issued 5,000 shares of its common stock to
an individual as a consulting fee for investor  relations  services.  The shares
were  valued at the time of  issuance  at $.75 per  share.  The  individual  was
provided with access to all material information  regarding an investment in the
Registrant and was given the opportunity to ask questions of and receive answers
from the executive  officers of the  Registrant.  Accordingly,  the issuance was
exempt from  registration  under the  Securities  Act  pursuant to Section  4(2)
thereunder.(1)

<PAGE>

         In August,  1999 the Registrant  sold an aggregate of 379,100 shares of
its  common  stock in a  private  placement  to 14  investors  for an  aggregate
consideration  of  $284,325  ($.75 per  share).  Each of the  purchasers  was an
existing shareholder of the Registrant and an accredited investor, as defined in
Regulation D ("Regulation  D") promulgated  under the Securities Act of 1933, as
amended (the  "Securities  Act"),  who was provided  with access to all material
information  regarding an  investment  in the  Registrant  and who was given the
opportunity to ask questions of and receive answers from the executive  officers
of the Registrant.  Accordingly,  these issuances were exempt from  registration
under the Securities Act pursuant to Section 4(2) thereunder.(1)

         In September,  1999 the  Registrant  issued 20,000 shares of its common
stock to an officer of the  Registrant  as employment  compensation.  The shares
were valued at the time of issuance at $.75 per share.  Such  officer had access
to  all  material  information   regarding  an  investment  in  the  Registrant.
Accordingly, this issuance was exempt from registration under the Securities Act
pursuant to Section 4(2) thereunder.(1)

         On November 1, 1999 the Registrant's  shareholders approved a three for
two reverse  stock split.  Prior to the split,  the  Registrant  had  12,981,773
common shares  outstanding and, following the split, there were 8,654,515 common
shares outstanding.

         During January and February,  2000 the Registrant  sold an aggregate of
172,796 shares of its common stock in a private placement to seven investors for
an  aggregate  consideration  of  $194,399  ($1.125  per  share).  Each  of  the
purchasers  was an existing  shareholder  of the  Registrant  and an  accredited
investor,  as defined in Regulation D  ("Regulation  D")  promulgated  under the
Securities Act of 1933, as amended (the "Securities Act"), who was provided with
access to all material information regarding an investment in the Registrant and
who was given the  opportunity to ask questions of and receive  answers from the
executive officers of the Registrant.  Accordingly,  these issuances were exempt
from   registration   under  the   Securities   Act  pursuant  to  Section  4(2)
thereunder.(1)

         On March 8, 2000,  the  Registrant  entered into a contract to purchase
land and, as part thereof, agreed to issue 102,000 shares of its common stock as
earnest money towards the total  purchase price of $1,189,515  (unaudited).  The
stock is being held by the seller's real estate agent pending the closing of the
sale.  The  purchaser  is an  accredited  investor,  as defined in  Regulation D
("Regulation  D") promulgated  under the Securities Act of 1933, as amended (the
"Securities  Act") and was  provided  with  access to all  material  information
regarding an investment in the Registrant  and was given the  opportunity to ask
questions of and receive answers from the executive  officers of the Registrant.
Accordingly,  these issuances were exempt from registration under the Securities
Act pursuant to Section 4(2) thereunder.(1)

<PAGE>

         During March, 2000 the Registrant sold an aggregate of 76,330 shares of
its common  stock in a private  placement  to nine  investors  for an  aggregate
consideration  of $85,874  ($1.125 per  share).  Each of the  purchasers  was an
existing shareholder of the Registrant and an accredited investor, as defined in
Regulation D ("Regulation  D") promulgated  under the Securities Act of 1933, as
amended (the  "Securities  Act"),  who was provided  with access to all material
information  regarding an  investment  in the  Registrant  and who was given the
opportunity to ask questions of and receive answers from the executive  officers
of the Registrant.  Accordingly,  these issuances were exempt from  registration
under the Securities Act pursuant to Section 4(2) thereunder.(1)

         All  stock  certificates   issued  in  connection  with  the  foregoing
transactions were legended to reflect their restricted status.

- -------------------

(1)      The sales and issuances of securities in these transactions were deemed
         by the Company to be exempt from  registration  under the Act by virtue
         of  section  4(2)  thereof as  transactions  not  involving  any public
         offering.  The recipients  represented  their  intention to acquire the
         securities for investment only and not with a view to the  distribution
         thereof.   All  shares  issued  to  these  persons   contained  legends
         restricting  transfer of the shares without  compliance with applicable
         securities laws. All recipients  either received  adequate  information
         regarding  the  Company  or had  access  through  employment  or  other
         relationships to such information.

(2)      The sales and issuances of securities in these transactions were deemed
         by the Company to be exempt from  registration  under the Act by virtue
         of  Regulation  D  under  the  Act.  The  recipients   represented  and
         acknowledged that:

         (a)      The  investor was  acquiring  the shares for  investment,  for
                  his/her  own  account  and  not  with  a  view  to  resale  or
                  distribution;

         (b)      The investor's overall commitment to investments which are not
                  readily marketable was  not disproportionate to the investor's
                  net worth,  and the  investment  in the shares would not cause
                  such overall commitment to become excessive;

         (c)      The  investor  had  sufficient  knowledge  and  experience  in
                  financial matters that he was capable of evaluating the merits
                  and risks of the  investment,  could bear the economic risk of
                  an investment for an indefinite  period of time and could,  at
                  the time of the investment,  afford a substantial  loss of his
                  investment;

         (d)      The investor had  evaluated  the merits and risks of investing
                  in the shares; and

         (e)      The investor  agreed that the  certificates  representing  the
                  shares  and the  common  shares  into  which the  shares  were
                  convertible  would  contain  and be  endorsed  with  a  legend
                  restricting  the transfer of such shares  unless such transfer
                  would not  violate  applicable  state and  federal  securities
                  laws.
<PAGE>

Item  27.  Exhibits

         (a)      Exhibits:

1.       Underwriting  and Selling  Agreement,  dated August 4, 1999 between the
         Registrant and Three Arrows Capital Corp.,  including Letter Agreement,
         dated August 3, 1999,  between the  Registrant and Three Arrows Capital
         Corp.*

1.1      Escrow Agreement,  dated May 15, 2000, by and among the Registrant, the
         Underwriter, Norwest Bank Colorado, N.A.**

3.1      Copy of Registrant's Amended and Restated Articles of Incorporation.*
3.1.1    Copy  of  Registrant's   Articles  of  Amendment  to  the  Articles  of
         Incorporation, as filed with the Colorado Secretary of State on October
         30, 1992.*
3.1.2    Copy  of  Registrant's   Articles  of  Amendment  to  the  Articles  of
         Incorporation,  as  filed  with  the  Colorado  Secretary  of  State on
         November 9, 1999.*
3.2      Copy of Registrant's Bylaws.*
4.1      Specimen Common Stock Certificate.*
4.2      Form of Subscription Agreement

5.1      Opinion by Reinhart, Boerner, Van Deuren, Norris & Rieselbach, P.C., as
         to legality of the shares of Common Stock offered by the Company.**

10.1     Copy of Second  Amendment  to  Employment  Agreement,  effective  as of
         January 1, 1999 between Registrant and Malcolm H. Benedict.*
10.2     Copy of  Employment  Agreement,  effective  as of April 1, 1998 between
         Registrant and Donald A. Ludwig, Ph.D.*
10.3     Letter of  Proposal,  dated  September  30,  1999,  from DVI  Financial
         Services, Inc. to the Registrant.*
10.4     Pre-Contract Agreement, dated March 11, 1998 between the Registrant and
         Ebco Technologies.*
10.5     Contract to Buy and Sell Real Estate,  dated March 8, 2000, between the
         Registrant and Horizon Investments, LLC.*
10.6     Agreement to Amend/Extend  Contract,  dated March 15,2000,  between the
         Registrant and Horizon Investments, LLC.*

23.1     Consent of Cordovano and Harvey, P.C.**
23.2     Consent of Reinhart,  Boerner, Van Deuren,  Norris & Rieselbach,  P.C.,
         (included in Exhibit 5.1).
27.1     Financial Data Schedule as of March 31, 2000.*


* Filed  with  the  Commission  on  March  31,  2000  as  part  of  Registrant's
Registration Statement on Form SB-2

** Filed  with  the  Commission  on  May 9,  2000.

<PAGE>

Item 28.  Undertakings.

         The undersigned Registrant hereby undertakes:

                  (1) To file  during  any  period in which  offers or sales are
         being  made   pursuant  to  Rule  415  under  the   Securities   Act  a
         post-effective amendment to this Registration Statement:

                           (i)      To  include  any   prospectus   required  by
                                    Section 10(a)(3) of the Securities Act;

                           (ii)     To  reflect in the  prospectus  any facts or
                                    events   which,   individually   or  in  the
                                    aggregate, represent a fundamental change in
                                    the   information   in   the    registration
                                    statement.  Notwithstanding  the  foregoing,
                                    any increase or decrease in the total dollar
                                    value of  securities  offered,  if the total
                                    dollar value of securities offered would not
                                    exceed  that which was  registered)  and any
                                    deviation  from  the low or high  end of the
                                    estimated  maximum  offering  range  may  be
                                    reflected  in the form of  prospectus  filed
                                    with the Securities and Exchange  Commission
                                    (the  "Commission")  pursuant to Rule 424(b)
                                    if, in the aggregate,  the changes in volume
                                    and  price  represent  no  more  than  a 20%
                                    change  in the  maximum  aggregate  offering
                                    price  set  forth  in  the  "Calculation  of
                                    Registration  Fee"  table  in the  effective
                                    registration statement;

                           (iii)    To  include   any   additional   or  changed
                                    material   information   on  the   plan   of
                                    distribution.

                  (2) For  determining  liability  under the Securities  Act, to
         treat each post-effective  amendment as a new registration statement of
         the securities offered, and the offering of the securities at that time
         to be the initial bona fide offering.

                  (3)  To  file  a  post-effective   amendment  to  remove  from
         registration any of the securities that remain unsold at the end of the
         offering.

<PAGE>

          Registrant  hereby  undertakes to provide to the  Underwriters  at the
closing   specified  in  the   Underwriting   Agreement   certificates  in  such
denominations  and registered in such names as required by the  Underwriters  to
permit prompt delivery to each purchaser.

          Insofar  as   indemnification   for  liabilities   arising  under  the
Securities  Act of 1933,  as amended (the "Act") may be permitted to  directors,
officers and controlling persons of Registrant pursuant to the provisions of its
Amended and Restated  Articles of  Incorporation,  as amended,  its Bylaws,  the
Colorado Business Corporation Act or otherwise, Registrant has been advised that
in the opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in the Act and is, therefore,  unenforceable.
In the event that a claim for  indemnification  against such liabilities  (other
than the  payment by  Registrant  for  expenses  incurred or paid by a director,
officer or  controlling  person of Registrant in the  successful  defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection  with the securities  being  registered,  Registrant  will,
unless in the opinion of its counsel the matter has been settled by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.

          The undersigned Registrant hereby undertakes:

                  (1) For  purposes  of  determining  any  liability  under  the
         Securities  Act,  to treat  the  information  omitted  from the form of
         prospectus  filed as part of this  registration  statement  in reliance
         upon  Rule  430A  and  contained  in a  form  of  prospectus  filed  by
         Registrant under Rule 424(b)(1), or (4), or 497(h) under the Securities
         Act  as  part  of  this  registration  statement  as of  the  time  the
         Commission declared it effective.

                  (2) For determining any liability under the Securities Act, to
         treat each post-effective  amendment that contains a form of prospectus
         as a new  registration  statement  for the  securities  offered  in the
         registration  statement,  and that  offering of the  securities at that
         time as the initial bona fide offering of those securities.


<PAGE>


                                   SIGNATURES


         In accordance  with the  requirements  of the  Securities  Act of 1933,
Registrant certifies that it has reasonable grounds to believe that it meets all
of the  requirements  for filing on Form SB-2 and authorized  this  Registration
Statement or amendment thereto to be signed on its behalf by the undersigned, in
the City of Longmont, State of Colorado, on the 15th day of May, 2000.


                                MOLECULAR DIAGNOSTICS & THERAPEUTICS, INC.

                                By: /s/ Malcolm H. Benedict
                                    -----------------------------------------
                                    Malcolm H. Benedict, Chairman of the
                                    Board, Chief Executive Officer, President
                                    and Treasurer

         In accordance with the requirements of the Securities Act of 1933, this
Registration  Statement  or amendment  thereto has been signed by the  following
persons in the capacities and on the dates stated.

       Signature                           Title                       Date
       ---------                          -------                      ----


/s/Malcolm H. Benedict            Chairman of the Board,            May 15, 2000
- -----------------------          Chief Executive Officer,
Malcolm H. Benedict        President, Treasurer and Director

/s/Donald A. Ludwig             Executive Vice President            May 15, 2000
- -----------------------                and Director
Donald A. Ludwig

/s/Janet L. Davis                Secretary and Director             May 15, 2000
- -----------------------
Janet L. Davis



                             SUBSCRIPTION AGREEMENT

         1.  Subscription.  Subject  to the  terms  and  conditions  hereof  the
undersigned,  intending  to be legally  bound,  irrevocably  subscribes  for and
agrees to purchase that number of shares of common stock ("Shares") of Molecular
Diagnostics and Therapeutics,  Inc., a Colorado corporation (the "Company"), set
forth  on the  signature  page  hereof,  for  the  price  stated  thereon.  This
subscription  is made in  connection  with an  offering  by the Company of up to
1,000,000  shares of its common stock sold pursuant to a registration  statement
on Form SB-2 under the  Securities  Act of 1933,  as amended  (the  "Ac").  This
Offering will continue until the Company has sold a maximum of 1,000,000  shares
totaling  $10,000,000 or the termination  date of May 15, 2001 whichever  occurs
first.  If the minimum is not  achieved by the  termination  date,  subscriber's
funds will be promptly returned without interest or deduction.


         2. Irrevocability. The undersigned hereby acknowledges and agrees that,
except  as  otherwise  provided  by the  laws of the  State  of  Colorado,  this
subscription  is  irrevocable  and the  undersigned is not entitled to cancel or
withdraw it.

         3. Joint and Several Undertaking;  Entities. If more than one person is
signing this Agreement,  each  representation,  warranty and undertaking  herein
shall be the joint and several representation,  warranty and undertaking of each
such person.  If the undersigned is a partnership,  corporation,  trust or other
entity, the undersigned  further represents and warrants that (a) the individual
executing  this  Agreement  has full power and  authority to execute and deliver
this Agreement on behalf of the undersigned;  (b) the undersigned has full right
and power to perform its obligations  pursuant to the provisions hereof; and (c)
the undersigned was not formed for the specific purpose of acquiring Shares.


<PAGE>


         4. Survival.  Each representation and warranty contained herein and all
information  furnished by the  undersigned  to the Company is true,  correct and
complete  in all  respects  as of the date  hereof,  and the same  will be true,
correct and  complete as of the date on which this  subscription  is accepted by
the Company,  as if made on such date. The undersigned  undertakes to notify the
Company  immediately  of any change in any  representation,  warranty,  or other
information  set forth  herein.  The  undersigned  agrees to indemnify  and hold
harmless the Underwriter and the Company, its officers, directors, and employees
from and against any and all loss,  damage or liability due to or arising out of
a breach of any such representation or warranty of the undersigned.

         5.  Non-assignment.  This  Agreement  shall  not be  assignable  by the
undersigned without the prior written consent of the Company.

         6. Acceptance by the Company.  The Company reserves the right to accept
or  reject  any  subscription  in  whole  or in part in its  sole  and  absolute
discretion.  No subscription will be effective until accepted by the Company. If
the Company decides to reject a subscription,  it will do so in writing within a
reasonable time after having received it.

         7. Governing Law. This Agreement  shall be governed by and construed in
accordance with the laws of the State of Colorado.


         Within five days of its receipt of a  subscription  agreement  from the
Underwriter,  confirming  that an  accompanying  check for the purchase price of
Shares has been received, following escrow, the Company will send by first-class
mail a written  confirmation to notify the subscriber of the extent,  if any, to
which  subscription  has been accepted by the Company.  The Company reserves the
right to reject orders for the purchases of Shares in whole or in part. Not more
than thirty days  following  the mailing of its written  confirmation,  and upon
achieving the minimum number of total shares to be sold, a  subscriber's  Common
Stock  certificate will be mailed by first-class mail. The Company shall not use
the proceeds paid by an investor until such time as the minimum number of shares
has been sold nor until the Common Stock certificate  evidencing such investment
has been mailed.

         Funds  will  be  deposited  to an  escrow  account  established  in the
Company's name at Norwest Investment  Management and Trust,  Corporate Trust and
Escrow Services, 1740 Broadway, Denver, CO 80274-8693.


<PAGE>


      Molecular Diagnostics and Therapeutics, Inc., Subscription Agreement

                                 Signature Page

         The undersigned, by executing this Signature Page, agrees to all of the
terms,   conditions,   warranties  and   representations   in  the  accompanying
Subscription Agreement, and subscribes for the number of shares of the Company's
Common Stock set forth below at a price of $10.00 per share.

         Number of Shares Subscribed for:    ___________________
         Total Purchase Price:              $___________________

         A check in the full amount of the purchase price, payable to "Molecular
Diagnostics and  Therapeutics,  Inc. Escrow Account"  accompanies  this executed
Subscription Agreement.

Form of Ownership:

         __Individual                         __Partnership
         __Joint Tenants With Rights of       __Trust
             survivorship (both sign)         __Limited Liability Company, LLC
         __Tenants in Common (all sign)       __Corporation

INDIVIDUALS

_________________________         _____________________________    ___________
Signature of Subscriber                        Print Name              Date

______________________________________________________________________________
Mailing Address

_________________________________      _______________________________________
Telephone Number                       Social Security Number




_________________________         _____________________________    ___________
Signature of Subscriber                        Print Name              Date

______________________________________________________________________________
Mailing Address

_________________________________      _______________________________________
Telephone Number                       Social Security Number

<PAGE>


CORPORATIONS, TRUSTS, PARTNERSHIP, LLCs

______________________________________________________________________________
Name of Corporation, Trust, Partnership or LLC

By:   ________________________________________   _____________________________
      Signature of Authorized Representative     Print Name

      ________________________________________   _____________________________
      Capacity of Authorized Representative      Date

______________________________________________________________________________
Mailing Address

**********************
Accepted as to              Shares on                         .
               ------------           ------------------------

Molecular Diagnostics and Therapeutics, Inc.

By:_________________________________________
      Its:__________________________________

Please make your check payable to: Molecular Diagnostics and Therapeutics,  Inc.
Escrow Account.

Mail to: Norwest Investment Management and Trust
         Corporate Trust and Escrow Services
         1740 Broadway
         Denver, CO  80274-8693

Are you an officer or director of a publicly held company? _______

Are you over 21 years of age? ______

Name of address of employer ________________________________________________

____________________________________________________________________________

Occupation_______________________________

Individual income $______________   with spouse $_________

Net Worth $___________________

Investment objective:  conservative ____ speculative ____ income____




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