GENAISSANCE PHARMACEUTICALS INC
S-1/A, EX-5.1, 2000-07-03
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                     EXHIBIT 5.1

                               PALMER & DODGE LLP
                    ONE BEACON STREET, BOSTON, MA 02108-3190

TELEPHONE: (617) 573-0100                              FACSIMILE: (617) 227-4420

                                  June 30, 2000

Genaissance Pharmaceuticals, Inc.
5 Science Park
New Haven, Connecticut  06511

Ladies and Gentlemen:

         We are rendering this opinion in connection with the Registration
Statement on Form S-1 (the "Registration Statement") filed by Genaissance
Pharmaceuticals, Inc. (the "Company") with the U.S. Securities and Exchange
Commission under the Securities Act of 1933, as amended, on or about the date
hereof. The Registration Statement relates to up to 6,900,000 shares of the
Company's Common Stock, $0.001 par value (the "Shares"), being sold by the
Company, including 900,000 Shares issuable upon exercise of the overallotment
option granted by the Company. We understand that the Shares are to be offered
and sold in the manner described in the Registration Statement.

         We have acted as your counsel in connection with the preparation of the
Registration Statement. We are familiar with the proceedings of the Board of
Directors in connection with the authorization, issuance and sale of the Shares
(the "Resolutions"). We have examined such other documents as we consider
necessary to render this opinion.

         Based upon the foregoing, we are of the opinion that the Shares have
been duly authorized and, when issued and delivered by the Company against
payment therefor at the price to be determined pursuant to the Resolutions, will
be validly issued, fully paid and non-assessable.

         The foregoing opinion is limited to Delaware General Corporation Law
and the federal laws of the United States.

         We hereby consent to the filing of this opinion as a part of the
Registration Statement and to the reference to our firm under the caption "Legal
Matters" in the Prospectus filed as part thereof.

                                                     Very truly yours,

                                                     /s/ Palmer & Dodge LLP

                                                     Palmer & Dodge LLP



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