GENAISSANCE PHARMACEUTICALS INC
S-8, EX-5.1, 2000-12-20
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                   EXHIBIT 5.1

                               PALMER & DODGE LLP
                    ONE BEACON STREET, BOSTON, MA 02108-3190


TELEPHONE: (617) 573-0100                             FACSIMILE: (617) 227-4420


                                December 20, 2000


Genaissance Pharmaceuticals, Inc.
Five Science Park
New Haven, Connecticut 06511

Ladies and Gentlemen:

         We have assisted in the preparation of a Registration Statement on Form
S-8 (the "Registration Statement") to be filed with the Securities and Exchange
Commission relating to 250,000 shares of Common Stock, $0.001 par value per
share (the "Shares"), of Genaissance Pharmaceuticals, Inc., a Delaware
corporation (the "Company"), issuable under the Company's Employee Stock
Purchase Plan 2000 (the "Plan").

         It is our opinion that the Shares have been duly authorized for
issuance and, when issued in accordance with the terms of the Plan, will be
legally issued, fully paid and nonassessable.

         We hereby consent to the use of our name in the Registration Statement
and consent to the filing of this opinion with the Securities and Exchange
Commission as an exhibit to the Registration Statement.

                                                     Very truly yours,


                                                     /s/ PALMER & DODGE LLP




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