GENAISSANCE PHARMACEUTICALS INC
S-1/A, EX-1.1, 2000-07-28
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                _________ Shares

                        GENAISSANCE PHARMACEUTICALS, INC.

                                  Common Stock

                                ($.001 Par Value)

                          EQUITY UNDERWRITING AGREEMENT

                                                                    ______, 2000

DEUTSCHE BANK SECURITIES INC.
BEAR, STEARNS & CO. INC.
SALOMON SMITH BARNEY, INC.
UBS WARBURG LLC
As Representatives of the Several Underwriters
c/o DEUTSCHE BANK SECURITIES INC.
One South Street
Baltimore, Maryland 21202

Ladies and Gentlemen:

         Genaissance Pharmaceuticals, Inc., a Delaware corporation (the
"Company"), proposes to sell to the several underwriters (the "Underwriters")
named in Schedule I hereto for whom you are acting as representatives (the
"Representatives") an aggregate of 6,000,000 shares of the Company's Common
Stock, $.001 par value (the "Firm Shares"). The respective amounts of the Firm
Shares to be so purchased by the several Underwriters are set forth opposite
their names in Schedule I hereto. The Company also proposes to sell at the
Underwriters' option an aggregate of up to 900,000 additional shares of the
Company's Common Stock (the "Option Shares") as set forth below.

         As the Representatives, you have advised the Company (a) that you are
authorized to enter into this Agreement on behalf of the several Underwriters,
and (b) that the several Underwriters are willing, acting severally and not
jointly, to purchase the numbers of Firm Shares set forth opposite their
respective names in Schedule I, plus their pro rata portion of the Option Shares
if you elect to exercise the over-allotment option in whole or in part for the
accounts of the several Underwriters. The Firm Shares and the Option Shares (to
the extent the aforementioned option is exercised) are herein collectively
called the "Shares."
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         The Company and the Underwriters agree that up to 300,000 shares of the
Common Stock to be purchased by the Underwriters (the "Reserved Shares") shall
be reserved for sale by the Underwriters to certain persons designated by the
Company, as part of the distribution of the Shares by the Underwriters, subject
to the terms of this Agreement, the applicable rules, regulations and
interpretations of the National Association of Securities Dealers, Inc. (the
"NASD") and all other applicable laws, rules and regulations. To the extent that
such Reserved Shares are not orally confirmed for purchase by such persons
designated by the Company by the end of the first business day after the date of
this Agreement, such Reserved Shares may be offered to the public as part of the
public offering contemplated hereby.

         In consideration of the mutual agreements contained herein and of the
interests of the parties in the transactions contemplated hereby, the parties
hereto agree as follows:

(1)      REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company represents
         and warrants to each of the Underwriters as follows:

         (a)      A registration statement on Form S-1 (File No. 333-35314) with
                  respect to the Shares has been prepared by the Company in
                  conformity in all material respects with the requirements of
                  the Securities Act of 1933, as amended (the "Act"), and the
                  Rules and Regulations (the "Rules and Regulations") of the
                  Securities and Exchange Commission (the "Commission")
                  thereunder (except, in the case of the preliminary prospectus
                  included in such registration statement at the time of its
                  initial filing, the omission of the number of shares and the
                  price range and the other information based thereon). Such
                  registration statement has been filed with the Commission and
                  the registration statement filed by electronic transmission
                  pursuant to the Commission's Electronic Data Gathering,
                  Analysis and Retrieval System ("EDGAR") (except as may be
                  permitted by Regulation S-T under the Act) was identical to
                  the copy thereof delivered to the Underwriters for use in
                  connection with the offer and sale of the Shares. The Company
                  has complied with any condition for the use of Form S-1.
                  Copies of such registration statement, including any
                  amendments thereto, the preliminary prospectuses (meeting the
                  requirements of the Rules and Regulations) contained therein
                  and the exhibits, financial statements and schedules, as
                  finally amended and revised, have heretofore been delivered by
                  the Company to you. Such registration statement, together with
                  any registration statement filed by the Company pursuant to
                  Rule 462(b) of the Act, herein referred to as the
                  "Registration Statement," which shall be deemed to include all
                  information omitted therefrom in reliance upon Rule 430A and
                  contained in the Prospectus referred to below, has become
                  effective under the Act and no post-effective amendment to the
                  Registration Statement has been filed as of the date of this
                  Agreement. "Prospectus" means the form of prospectus first
                  filed with the Commission pursuant to Rule 424(b). Each
                  preliminary prospectus included in the Registration Statement
                  prior to the time it becomes effective is herein referred to
                  as a "Preliminary Prospectus." Any reference herein to the
                  Registration Statement, any Preliminary Prospectus or the
                  Prospectus shall be deemed to refer to and include any
                  supplements or amendments thereto, filed with the Commission
                  after the date of filing of the Prospectus under Rules

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                  424(b) or 430A and prior to the termination of the offering
                  of the Shares by the Underwriters.

         (b)      The Company has not distributed and will not distribute, prior
                  to the later of the Option Closing Date (as defined below) and
                  the completion of the Underwriters' distribution of the
                  Shares, any offering material in connection with the offering
                  and sale of the Shares other than the Preliminary Prospectus,
                  the Prospectus or the Registration Statement.

         (c)      This Agreement has been duly authorized, executed and
                  delivered by, and is a valid and binding agreement of, the
                  Company, enforceable against the Company in accordance with
                  its terms, except as rights to indemnification hereunder may
                  be limited by applicable law and except as the enforcement
                  hereof may be limited by bankruptcy, insolvency,
                  reorganization, moratorium or other similar laws relating to
                  or affecting the rights and remedies of creditors or by
                  general equitable principles.

         (d)      The Company has been duly organized and is validly existing as
                  a corporation in good standing under the laws of the State of
                  Delaware, with corporate power and authority to own or lease
                  its properties and conduct its business as described in the
                  Registration Statement and to enter into and perform its
                  obligations under this Agreement. There are no subsidiaries,
                  direct or indirect, of the Company and the Company does not
                  own or control, directly or indirectly, any corporation,
                  association or other entity. The Company is duly qualified to
                  transact business in all jurisdictions in which the failure to
                  be so qualified would have a material adverse affect on the
                  business of the Company.

         (e)      The outstanding shares of Common Stock of the Company have
                  been duly authorized and validly issued and are fully paid and
                  non-assessable; the Shares to be issued and sold by the
                  Company have been duly authorized and when issued and paid for
                  as contemplated herein will be validly issued, fully paid and
                  non-assessable; and no preemptive rights of stockholders are
                  applicable with respect to any of the Shares or the issue and
                  sale thereof. None of the outstanding shares of Common Stock
                  were issued in violation of any preemptive rights, rights of
                  first refusal or other rights to subscribe for or purchase
                  securities of the Company. There are no authorized or
                  outstanding options, warrants, preemptive rights (except for
                  preemptive rights terminating upon the consummation of this
                  Agreement), rights of first refusal or other rights to
                  purchase, or equity or debt securities convertible into or
                  exchangeable or exercisable for, any capital stock of the
                  Company other than those described in the Prospectus. Neither
                  the filing of the Registration Statement nor the offering or
                  sale of the Shares as contemplated by this Agreement gives
                  rise to any rights, other than those which have been waived or
                  satisfied, for or relating to the registration of any shares
                  of Common Stock, which rights, if any, are described in the
                  Prospectus under the heading "Description of Capital Stock"
                  and "Shares Eligible for Future Sale." The description of the
                  Company's stock option and other stock plans or arrangements,
                  and the options or other rights granted

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                  thereunder, set forth in the Prospectus accurately and
                  fairly presents in all material respects the information
                  required to be shown with respect to such plans,
                  arrangements, options and rights.

         (f)      The Shares have been approved for quotation on the Nasdaq
                  Stock Market, subject only to official notice of issuance.

         (g)      The information set forth under the caption "Capitalization"
                  in the Prospectus is true and correct. All of the Shares
                  conform in all material respects to the description thereof
                  contained in the Registration Statement. The form of
                  certificates for the Shares conforms to the corporate law of
                  the jurisdiction of the Company's incorporation.

         (h)      The Commission has not issued an order preventing or
                  suspending the use of any Prospectus relating to the proposed
                  offering of the Shares nor instituted proceedings for that
                  purpose. The Registration Statement contains, and the
                  Prospectus and any amendments or supplements thereto will
                  contain, all statements which are required to be stated
                  therein by, and will conform in all material respects, to the
                  requirements of the Act and the Rules and Regulations. The
                  Registration Statement and any amendment thereto do not
                  contain, and will not contain, any untrue statement of a
                  material fact and do not omit, and will not omit, to state any
                  material fact required to be stated therein or necessary to
                  make the statements therein not misleading. The Prospectus and
                  any amendments and supplements thereto do not contain, and
                  will not contain, any untrue statement of material fact and do
                  not omit, and will not omit, to state any material fact
                  required to be stated therein or necessary to make the
                  statements therein, in the light of the circumstances under
                  which they were made, not misleading; provided, however, that
                  the Company makes no representations or warranties as to
                  information contained in or omitted from the Registration
                  Statement or the Prospectus, or any such amendment or
                  supplement, in reliance upon, and in conformity with, written
                  information furnished to the Company by or on behalf of any
                  Underwriter through the Representatives, specifically for use
                  in the preparation thereof.

         (i)      The financial statements of the Company, together with related
                  notes and schedules as set forth in the Registration
                  Statement, present fairly the financial position and the
                  results of operations and cash flows of the Company at the
                  indicated dates and for the indicated periods. Such financial
                  statements and related schedules have been prepared in
                  accordance with generally accepted accounting principles,
                  consistently applied throughout the periods involved, except
                  as disclosed therein, and all adjustments necessary for a fair
                  presentation of results for such periods have been made. No
                  other financial statements or supporting schedules are
                  required to be included in the Registration Statement. The
                  summary financial and statistical data included in the
                  Registration Statement presents fairly the information shown
                  therein and such data has been compiled on a basis consistent
                  with the financial statements presented therein and the books
                  and records of the Company. The pro forma financial statements
                  and

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                  other pro forma financial information included in the
                  Registration Statement and the Prospectus present fairly
                  the information shown therein, have been prepared in
                  accordance with the Commission's rules and guidelines with
                  respect to pro forma financial statements, have been
                  properly compiled on the pro forma basis described therein,
                  and, in the opinion of the Company, the assumptions used in
                  the preparation thereof are reasonable and the adjustments
                  used therein are appropriate to give effect to the
                  transactions or circumstances referred to therein.

         (j)      Arthur Andersen LLP, who have certified certain of the
                  financial statements filed with the Commission as part of the
                  Registration Statement, are independent public accountants as
                  required by the Act and the Rules and Regulations.

         (k)      There is no action, suit, claim or proceeding pending or, to
                  the knowledge of the Company, threatened against the Company
                  before any court or administrative agency or otherwise which
                  if determined adversely to the Company might result in any
                  material adverse change in the earnings, business, management,
                  properties, assets, rights, operations, condition (financial
                  or otherwise) or prospects of the Company or to prevent the
                  consummation of the transactions contemplated hereby, except
                  as set forth in the Registration Statement.

         (l)      The Company has good and marketable title to all of the
                  properties and assets reflected in the financial statements
                  hereinabove described (or as described in the Registration
                  Statement), and such properties and assets are not subject to
                  any lien, mortgage, pledge, charge or encumbrance of any kind
                  except those reflected in such financial statements (or as
                  described in the Registration Statement) or which are not
                  material in amount. The Company occupies its leased properties
                  under valid and binding leases conforming in all material
                  respects to the description thereof set forth in the
                  Registration Statement.

         (m)      The Company has filed all federal, state, local and foreign
                  tax returns which have been required to be filed and have paid
                  all taxes indicated by said returns and all assessments
                  received by it to the extent that such taxes have become due.
                  All tax liabilities have been adequately provided for in the
                  financial statements of the Company, and the Company does not
                  know of any actual or proposed additional material tax
                  assessments.

         (n)      Since the respective dates as of which information is given in
                  the Registration Statement, as it may be amended or
                  supplemented, there has not been any material adverse change
                  or any development involving a prospective material adverse
                  change in or affecting the earnings, business, management,
                  properties, assets, rights, operations, condition (financial
                  or otherwise), or prospects of the Company, whether or not
                  occurring in the ordinary course of business, and there has
                  not been any material transaction entered into or any material
                  transaction that is probable of being entered into by the
                  Company, other than transactions in the ordinary course of
                  business and changes and transactions

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                  described in the Registration Statement, as it may be
                  amended or supplemented. The Company has no material
                  contingent obligations which are not disclosed in the
                  Company's financial statements, including the notes
                  thereto, included in the Registration Statement.

         (o)      The Company is not, nor with the giving of notice or lapse of
                  time or both, will it be, in violation of or in default under
                  its charter or by-laws or under any agreement, lease,
                  contract, indenture or other instrument or obligation to which
                  it is a party or by which it, or any of its properties or
                  assets, is bound and which default is of material significance
                  in respect of the condition, financial or otherwise of the
                  Company or the business, management, properties, assets,
                  rights, operations, condition (financial or otherwise) or
                  prospects of the Company. The execution and delivery of this
                  Agreement and the consummation of the transactions herein
                  contemplated and the fulfillment of the terms hereof will not
                  conflict with or result in a breach of any of the terms or
                  provisions of, or constitute a default under, any indenture,
                  mortgage, deed of trust or other agreement or instrument to
                  which the Company is a party or by which its properties or
                  assets are bound, or of the charter or by-laws of the Company
                  or any order, rule or regulation applicable to the Company of
                  any court or of any regulatory body or administrative agency
                  or other governmental body having jurisdiction.

         (p)      Each approval, consent, order, authorization, designation,
                  declaration or filing by or with any regulatory,
                  administrative or other governmental body necessary in
                  connection with the execution and delivery by the Company of
                  this Agreement and the consummation of the transactions herein
                  contemplated (except such additional steps as may be required
                  by the Commission, the NASD or such additional steps as may be
                  necessary to qualify the Shares for public offering by the
                  Underwriters under state securities or blue sky laws) has been
                  obtained or made and is in full force and effect.

         (q)      The Company holds all material licenses, certificates and
                  permits from governmental authorities that are necessary for
                  the conduct of the Company's business.

         (r)      The Company is conducting its business in compliance in all
                  material respects with all applicable local, state, federal
                  and foreign laws, rules and regulations, including without
                  limitation, all such laws, rules and regulations of the
                  jurisdictions in which the Company is conducting business.

         (s)      The Company owns or possesses adequate licenses or other
                  rights to use the patents and patent applications (the
                  "Company Patents"), trademarks, trade names, service marks,
                  copyrights, licenses, approvals, inventions, know-how
                  (including trade secrets and other unpatented and/or
                  unpatentable proprietary or confidential information, systems
                  or procedures) and other similar rights and intellectual
                  property necessary to conduct its business as now conducted
                  (collectively, the "Company Intellectual Property") and has
                  taken all steps

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                  reasonably necessary to secure assignments of such
                  intellectual property from its employees and contractors;
                  to the knowledge of the Company, none of the technology
                  employed by the Company has been obtained or is being used
                  by the Company in violation of any contractual or fiduciary
                  obligation binding on the Company, its directors or
                  executive officers or, to the Company's knowledge, any of
                  its employees or consultants; and the Company has taken and
                  will maintain reasonable measures to prevent the
                  unauthorized dissemination or publication of its
                  confidential information. The Company Patents are listed on
                  Exhibit A hereto.

                  The Company knows of no material infringement by others of
                  patents, patent rights, trade names, trademarks or copyrights
                  owned by or licensed to the Company, except as disclosed in
                  the Registration Statement. The Company has good and
                  marketable title to the patents and patent applications
                  referred to in the Prospectus except as disclosed in the
                  Registration Statement.

                  The Company has not infringed, interfered with or
                  misappropriated any patents, patent rights, trade names,
                  trademarks, copyrights or other intellectual property rights
                  of others, which infringement, if the subject of any
                  unfavorable decision, ruling or finding would, individually or
                  in the aggregate, be reasonably likely to result in a material
                  adverse change in the earnings, business, management,
                  properties, assets, rights, operations, condition (financial
                  or otherwise) or prospects of the Company.

                  To the Company's knowledge, there are no legal or governmental
                  proceedings pending relating to trademarks, trade names,
                  patent rights, mask works, copyrights, licenses, trade secrets
                  or other intellectual property rights of the Company other
                  than the prosecution by the Company or its outside patent
                  counsel of its patent applications and trademarks before the
                  United States Patent and Trademark Office ("PTO") and
                  appropriate foreign government agencies, and no proceedings
                  are threatened or contemplated by governmental authorities or
                  others relating to trademarks, trade names, patent rights,
                  mask works, copyrights, licenses or other intellectual
                  property rights of the Company.

                  The Company has duly and properly filed or caused to be filed
                  with the PTO and applicable foreign and international patent
                  authorities as indicated all patent applications listed on
                  Exhibit A (the "Company Patent Applications"); in connection
                  with the filing of the Company Patent Applications, the
                  Company conducted reasonable investigations of the published
                  literature and patent references relating to the inventions
                  claimed in such applications; to the Company's knowledge, it
                  has complied with the PTO's duty of candor and disclosure for
                  the Company Patent Applications and has made no
                  misrepresentation in the Company Patent Applications; the
                  Company is unaware of any facts material to a determination of
                  patentability regarding the Company Patent Applications not
                  called to the attention of the PTO; the Company is unaware of
                  any facts not called to the attention of the PTO which would
                  preclude the grant of a patent for the Company Patent
                  Applications; and the Company has

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                  no knowledge of any facts which would preclude it from
                  having clear title to the Company Patent Applications
                  except as disclosed in the Registration Statement.

         (t)      Neither the Company, nor any of its affiliates, has taken or
                  will take, directly or indirectly, any action designed to
                  cause or result in, or which has constituted or which might
                  reasonably be expected to constitute, the stabilization or
                  manipulation of the price of the shares of Common Stock to
                  facilitate the sale or resale of the Shares. The Company
                  acknowledges that the Underwriters may engage in passive
                  market making transactions in the Shares on the Nasdaq Stock
                  Market in accordance with Rule 103 of Regulation M under the
                  Exchange Act.

         (u)      The Company is not, and after the issuance and sale of, and
                  the receipt of payment for, the Shares and the application of
                  the net proceeds therefrom as described in the Prospectus will
                  not be, an "investment company" or an entity "controlled" by
                  an "investment company" within the meaning of the Investment
                  Company Act of 1940, as amended (the "1940 Act"), and the
                  rules and regulations of the Commission thereunder.

         (v)      The Company maintains a system of internal accounting controls
                  sufficient to provide reasonable assurances that (i)
                  transactions are executed in accordance with management's
                  general or specific authorization; (ii) transactions are
                  recorded as necessary to permit preparation of financial
                  statements in conformity with generally accepted accounting
                  principles and to maintain accountability for assets; (iii)
                  access to assets is permitted only in accordance with
                  management's general or specific authorization; and (iv) the
                  recorded accountability for assets is compared with existing
                  assets at reasonable intervals and appropriate action is taken
                  with respect to any differences.

         (w)      The Company carries, or is covered by, insurance in such
                  amounts and covering such risks as is adequate for the conduct
                  of its business and the value of its properties and as is
                  customary for companies engaged in similar industries.

         (x)      The Company is in compliance in all material respects with all
                  currently applicable provisions of the Employee Retirement
                  Income Security Act of 1974, as amended, including the
                  regulations and published interpretations thereunder ("ERISA")
                  for which failure to comply would have a material adverse
                  effect upon the business of the Company; no "reportable event"
                  (as defined in ERISA) has occurred with respect to any
                  "pension plan" (as defined in ERISA) for which the Company
                  would have any material liability; the Company has not
                  incurred and does not expect to incur liability under (i)
                  Title IV of ERISA with respect to termination of, or
                  withdrawal from, any "pension plan" or (ii) Sections 412 or
                  4971 of the Internal Revenue Code of 1986, as amended,
                  including the regulations and published interpretations
                  thereunder (the "Code"); and each "pension plan" for which the
                  Company would have any liability that is intended to be
                  qualified under Section 401(a) of the Code is so qualified in
                  all material respects and to the Company's knowledge nothing
                  has occurred,

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                  whether by action or by failure to act, which would cause
                  the loss of such qualification.

         (y)      To the Company's knowledge, there are no affiliations or
                  associations between any member of the NASD and any of the
                  Company's officers, directors or securityholders, except as
                  set forth in the Registration Statement.

         (z)      Subsequent to the respective dates as of which information is
                  given in the Registration Statement, (i) the Company has not
                  incurred any material liability or obligation, direct or
                  contingent, nor entered into any material transaction not in
                  the ordinary course of business; (ii) the Company has not
                  purchased any of its outstanding capital stock, nor declared,
                  paid or otherwise made any dividend or distribution of any
                  kind on its capital stock other than ordinary and customary
                  dividends; and (iii) there has not been any material change in
                  the capital stock, short-term debt or long-term debt of the
                  Company, except in each case as described in such Registration
                  Statement.

         (aa)     No material labor dispute with the employees of the Company
                  exists, or to the knowledge of the Company, is imminent; and
                  the Company is not aware of any existing, threatened or
                  imminent labor disturbance by the employees of any of its
                  principal suppliers, manufacturers or contractors that could
                  result in any material adverse effect on the Company.

         (bb)     There are no business relationships or related-party
                  transactions involving the Company or any other person
                  required to be described in the Prospectus which have not been
                  described as required by the Act or the Rules and Regulations.

         (cc)     Neither the Company nor, to the best of the Company's
                  knowledge, any employee or agent of the Company, has made any
                  contribution or other payment to any official of, or candidate
                  for, any federal, state or foreign office in violation of any
                  law or of a character required to be disclosed in the
                  Prospectus.

         (dd)     The Registration Statement, the Prospectus and any Preliminary
                  Prospectus comply, and any amendments or supplements thereto
                  will comply, with any applicable laws or regulations of
                  foreign jurisdictions in which the Prospectus or any
                  Preliminary Prospectus, as amended or supplemented, if
                  applicable, are distributed in connection with the offering,
                  issuance and sale of Reserved Shares.

         (ee)     No consent, approval, authorization or order of, or
                  qualification with, any governmental body or agency, other
                  than those obtained, is required in connection with the
                  offering of the Reserved Shares in any jurisdiction where the
                  Reserved Shares are being offered.

         (ff)     The Company has not offered, or caused any Representative or
                  its affiliates to offer, nor will it offer or cause any
                  Representative or its affiliates to offer, any

                                      9
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                  Reserved Shares to any person with the specific intent to
                  unlawfully influence (i) a customer or supplier of the
                  Company to alter the customer's or supplier's level or type
                  of business with the Company, or (ii) a trade journalist or
                  publication to write or publish favorable information about
                  the Company or its services.

         (gg)     The Company is not in violation of any federal, state, local
                  or foreign statute, law, rule, regulation, ordinance, code,
                  policy or rule of common law or any judicial or administrative
                  interpretation thereof, including any judicial or
                  administrative order, consent, decree or judgment, relating to
                  pollution or protection of human health, the environment
                  (including, without limitation, ambient air, surface water,
                  groundwater, land surface or subsurface strata) or wildlife,
                  including, without limitation, laws and regulations relating
                  to the emission, discharge, release or threatened release of
                  chemicals, pollutants, contaminants, wastes, toxic substances,
                  hazardous substances, petroleum or petroleum products
                  (collectively, "Hazardous Materials") or to the manufacture,
                  processing, distribution, use, treatment, storage, disposal,
                  transport or handling of Hazardous Materials (collectively,
                  "Environmental Laws") in any material respects, nor has the
                  Company received any written communication, whether from a
                  governmental authority, citizens group, employee or otherwise,
                  that alleges that the Company is in violation of any
                  Environmental Law, except for violations which do not,
                  individually or in the aggregate, have a material adverse
                  effect upon the business of the Company. The Company has all
                  permits, authorizations and approvals required under any
                  applicable Environmental Laws and is in compliance in all
                  material respects with their requirements for which failure to
                  obtain such permits, authorizations and approvals would have a
                  material adverse effect upon the business of the Company.
                  There is no claim, action or cause of action filed with a
                  court or governmental authority or any administrative,
                  regulatory or judicial actions, suits, demands, demand
                  letters, claims, liens, notices of noncompliance or violation,
                  investigation or proceedings with respect to which the Company
                  has received written notice, and no written notice to the
                  Company by any person or entity alleging potential liability
                  for investigatory costs, cleanup costs, governmental responses
                  costs, natural resources damages, property damages, personal
                  injuries, attorneys' fees or penalties arising out of, based
                  on or resulting from the presence, or release into the
                  environment, of any Hazardous Materials at any location owned,
                  leased or operated by the Company now or in the past
                  (collectively, "Environmental Claims"), pending or, to the
                  best of the Company's knowledge, threatened against the
                  Company or any person or entity whose liability for any
                  Environmental Claim the Company has retained or assumed either
                  contractually or by operation of law nor are there any events
                  or circumstances that might reasonably be expected to form the
                  basis for an Environmental Claim. To the best of the Company's
                  knowledge, there are no past or present actions, activities,
                  circumstances, conditions, events or incidents, including,
                  without limitation, the release, emission, discharge, presence
                  or disposal of any Hazardous Materials, that reasonably could
                  result in a violation of any Environmental Law or form the
                  basis of a potential

                                     10
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                  Environmental Claim against the Company or against any person
                  or entity whose liability for any Environmental Claim the
                  Company has retained or assumed either contractually or by
                  operation of law which would have a material adverse effect
                  upon the business of the Company.

         (hh)     The Company has reviewed its operations and any third parties
                  with which the Company has a material relationship to evaluate
                  the extent to which the business or operations of the Company
                  will be affected by the Year 2000 Problem. As a result of such
                  review, the Company has no reason to believe, and does not
                  believe, that the Year 2000 Problem will result in a material
                  adverse change in the earnings, business, management,
                  properties, assets, rights, operations, condition (financial
                  or otherwise) or prospects of the Company or result in any
                  material loss or interference with the Company's business or
                  operations. The "Year 2000 Problem" as used herein means any
                  significant risk that computer hardware or software used in
                  the receipt, transmission, processing, manipulation, storage,
                  retrieval, retransmission or other utilization of data or in
                  the operation of mechanical or electrical systems of any kind
                  will not, in the case of dates or time periods occurring after
                  December 31, 1999, function at least as effectively as in the
                  case of dates or time periods occurring prior to January 1,
                  2000.

         (ii)     Any certificate signed by an officer of the Company delivered
                  to the Representatives or to counsel for the Underwriters
                  pursuant to this Agreement or in connection with the Closing
                  contemplated hereby shall be deemed to be a representation and
                  warranty by the Company to each Underwriter as to the matters
                  covered thereby.

(2)      PURCHASE, SALE AND DELIVERY OF THE FIRM SHARES.

         (a)      On the basis of the representations, warranties and covenants
                  herein contained, and subject to the conditions herein set
                  forth, the Company agrees to sell to the Underwriters and each
                  Underwriter agrees, severally and not jointly, to purchase, at
                  a price of $____ per share, the number of Firm Shares set
                  forth opposite the name of each Underwriter in Schedule I
                  hereof, subject to adjustments in accordance with Section 9
                  hereof.

         (b)      Payment for the Firm Shares to be sold hereunder is to be made
                  in New York Clearing House funds by federal (same day) funds
                  against delivery of certificates therefor to the
                  Representatives for the several accounts of the Underwriters.
                  Such payment and delivery are to be made through the
                  facilities of the Depository Trust Company, New York, New York
                  at 10:00 a.m., New York time, on the third business day after
                  the date of this Agreement or at such other time and date not
                  later than five business days thereafter as you and the
                  Company shall agree upon, such time and date being herein
                  referred to as the "Closing Date." As used herein, "business
                  day" means a day on which the New York Stock Exchange is open
                  for trading and on which banks in New York are open for
                  business and are not permitted by law or executive order to



                                      11
<PAGE>

                  be closed. The certificates for the Firm Shares, if any, will
                  be delivered in such denominations and in such registrations
                  as the Representatives may request in writing not later than
                  the second full business day prior to the Closing Date, and
                  will be made available for inspection by the Representatives
                  at least one business day prior to the Closing Date.

         (c)      In addition, on the basis of the representations and
                  warranties herein contained and subject to the terms and
                  conditions herein set forth, the Company hereby grants an
                  option to the several Underwriters to purchase the Option
                  Shares at the price per share as set forth in the first
                  paragraph of this Section 2. The option granted hereby may be
                  exercised in whole or in part by giving written notice (i) at
                  any time before the Closing Date and (ii) only once thereafter
                  within 30 days after the date of this Agreement, by you, as
                  Representatives of the several Underwriters, to the Company
                  setting forth the number of Option Shares as to which the
                  several Underwriters are exercising the option, the names and
                  denominations in which the Option Shares are to be registered
                  and the time and date at which such certificates are to be
                  delivered. The time and date at which certificates for Option
                  Shares (if any) are to be delivered shall be determined by the
                  Representatives but shall not be earlier than three nor later
                  than 10 full business days after the exercise of such option,
                  nor in any event prior to the Closing Date (such time and date
                  being herein referred to as the "Option Closing Date"). If the
                  date of exercise of the option is three or more days before
                  the Closing Date, the notice of exercise shall set the Closing
                  Date as the Option Closing Date. The number of Option Shares
                  to be purchased by each Underwriter shall be in the same
                  proportion to the total number of Option Shares being
                  purchased as the number of Firm Shares being purchased by such
                  Underwriter bears to the total number of Firm Shares being
                  sold hereunder, adjusted by you in such manner as to avoid
                  fractional shares. The option with respect to the Option
                  Shares granted hereunder may be exercised only to cover
                  over-allotments in the sale of the Firm Shares by the
                  Underwriters. You, as Representatives of the several
                  Underwriters, may cancel such option at any time prior to its
                  expiration by giving written notice of such cancellation to
                  the Company. To the extent, if any, that the option is
                  exercised, payment for the Option Shares shall be made on the
                  Option Closing Date in federal (same day) funds through the
                  facilities of the Depository Trust Company in New York, New
                  York drawn to the order of the Company.

(3)      OFFERING BY THE UNDERWRITERS.

         It is understood that the several Underwriters are to make a public
offering of the Firm Shares as soon as the Representatives deem it advisable to
do so. The Firm Shares are to be initially offered to the public at the initial
public offering price set forth in the Prospectus. The Representatives may from
time to time thereafter change the public offering price and other selling
terms. To the extent, if at all, that any Option Shares are purchased pursuant
to Section 2 hereof, the Underwriters will offer them to the public on the
foregoing terms.


                                      12
<PAGE>


         It is further understood that you will act as the Representatives for
the Underwriters in the offering and sale of the Shares in accordance with a
Master Agreement Among Underwriters entered into by you and the several other
Underwriters, a copy of which has been furnished to the Company. Any short
position effected by the Underwriters on behalf of the syndicate in excess of
the over-allotment shall not be greater than that set forth in the Master
Agreement Among Underwriters as of the date hereof.

(4)      COVENANTS OF THE COMPANY. The Company covenants and agrees with the
         several Underwriters that:

         (a)      The Company will (A) use its best efforts to cause the
                  Registration Statement to become effective or, if the
                  procedure in Rule 430A of the Rules and Regulations is
                  followed, to prepare and timely file with the Commission under
                  Rule 424(b) of the Rules and Regulations a Prospectus in a
                  form approved by the Representatives containing information
                  previously omitted at the time of effectiveness of the
                  Registration Statement in reliance on Rule 430A of the Rules
                  and Regulations, (B) not file any amendment to the
                  Registration Statement or supplement to the Prospectus of
                  which the Representatives shall not previously have been
                  advised and furnished with a copy or to which the
                  Representatives shall have reasonably objected in writing or
                  which is not in compliance with the Rules and Regulations, and
                  (C) file on a timely basis all reports and any definitive
                  proxy or information statements required to be filed by the
                  Company with the Commission subsequent to the date of the
                  Prospectus and prior to the termination of the offering of the
                  Shares by the Underwriters.

         (b)      The Company will advise the Representatives promptly (A) when
                  the Registration Statement or any post-effective amendment
                  thereto shall have become effective, (B) of receipt of any
                  comments from the Commission, (C) of any request of the
                  Commission for amendment of the Registration Statement or for
                  supplement to the Prospectus or for any additional
                  information, and (D) of the issuance by the Commission of any
                  stop order suspending the effectiveness of the Registration
                  Statement or the use of the Prospectus or of the institution
                  of any proceedings for that purpose. The Company will use its
                  best efforts to prevent the issuance of any such stop order
                  preventing or suspending the use of the Prospectus and to
                  obtain as soon as possible the lifting thereof, if issued.

         (c)      The Company will cooperate with the Representatives in
                  endeavoring to qualify the Shares for sale under the
                  securities laws of such jurisdictions as the Representatives
                  may reasonably have designated in writing and will make such
                  applications, file such documents, and furnish such
                  information as may be reasonably required for that purpose,
                  provided the Company shall not be required to qualify as a
                  foreign corporation or to file a general consent to service of
                  process in any jurisdiction where it is not now so qualified
                  or required to file such a consent. The Company will, from
                  time to time, prepare and file such statements, reports, and
                  other documents, as are or may be required to continue such
                  qualifications in effect for so long a period as the
                  Representatives may reasonably request for distribution of the
                  Shares.



                                      13
<PAGE>


         (d)      The Company will deliver to, or upon the order of, the
                  Representatives, from time to time, as many copies of any
                  Preliminary Prospectus as the Representatives may reasonably
                  request. The Company will deliver to, or upon the order of,
                  the Representatives during the period when delivery of a
                  Prospectus is required under the Act, as many copies of the
                  Prospectus in final form, or as thereafter amended or
                  supplemented, as the Representatives may reasonably request.
                  The Company will deliver to the Representatives at or before
                  the Closing Date, four signed copies of the Registration
                  Statement and all amendments thereto including all exhibits
                  filed therewith, and will deliver to the Representatives such
                  number of copies of the Registration Statement (including such
                  number of copies of the exhibits filed therewith that may
                  reasonably be requested), and of all amendments thereto, as
                  the Representatives may reasonably request.

         (e)      The Company will comply with the Act and the Rules and
                  Regulations, and the Securities Exchange Act of 1934, as
                  amended (the "Exchange Act"), and the rules and regulations of
                  the Commission thereunder, so as to permit the completion of
                  the distribution of the Shares as contemplated in this
                  Agreement and the Prospectus. If during the period in which a
                  prospectus is required by law to be delivered by an
                  Underwriter or dealer, any event shall occur as a result of
                  which, in the judgment of the Company or in the reasonable
                  opinion of the Underwriters, it becomes necessary to amend or
                  supplement the Prospectus in order to make the statements
                  therein, in the light of the circumstances existing at the
                  time the Prospectus is delivered to a purchaser, not
                  misleading, or, if it is necessary at any time to amend or
                  supplement the Prospectus to comply with any law, the Company
                  promptly will prepare and file with the Commission an
                  appropriate amendment to the Registration Statement or
                  supplement to the Prospectus so that the Prospectus as so
                  amended or supplemented will not, in the light of the
                  circumstances when it is so delivered, be misleading, or so
                  that the Prospectus will comply with the law.

         (f)      The Company hereby agrees that it will ensure that the
                  Reserved Shares will be restricted as required by the NASD or
                  the NASD rules from sale, transfer, assignment, pledge or
                  hypothecation for a period of three months following the date
                  of this Agreement. The Underwriters will notify the Company as
                  to which persons will need to be so restricted. At the request
                  of the Underwriters, the Company will direct the transfer
                  agent to place a stop transfer restriction upon such
                  securities for such period of time. Should the Company
                  release, or seek to release, from such restrictions any of the
                  Reserved Shares, the Company agrees to reimburse the
                  Underwriters for any reasonable expenses (including, without
                  limitation, legal expenses) they incur in connection with such
                  release.

         (g)      The Company will make generally available to its security
                  holders, as soon as it is practicable to do so, but in any
                  event not later than 15 months after the effective date of the
                  Registration Statement, an earning statement (which need not
                  be audited) in reasonable detail, covering a period of at
                  least 12 consecutive



                                      14
<PAGE>

                  months beginning after the effective date of the
                  Registration Statement, which earning statement shall
                  satisfy the requirements of Section 11(a) of the Act and
                  Rule 158 of the Rules and Regulations and will advise you
                  in writing when such statement has been so made available.

         (h)      Prior to the Closing Date, the Company will furnish to the
                  Underwriters, as soon as they have been prepared by or are
                  available to the Company, a copy of any unaudited interim
                  financial statements of the Company for any period subsequent
                  to the period covered by the most recent financial statements
                  appearing in the Registration Statement and the Prospectus.

         (i)      No offering, sale, short sale or other disposition of any
                  shares of Common Stock of the Company or other securities
                  convertible into or exchangeable or exercisable for shares of
                  Common Stock or derivative of Common Stock (or agreement for
                  such) will be made for a period of 180 days after the date of
                  this Agreement, directly or indirectly, by the Company
                  otherwise than hereunder or with the prior written consent of
                  Deutsche Bank Securities Inc., except (i) for issuance by the
                  Company of shares of Common Stock upon the exercise of an
                  option or warrant or the conversion of a security outstanding
                  on the date hereof, (ii) for the grant by the Company of any
                  option or right to purchase shares of Common Stock pursuant to
                  the Company's stock option plan and employee purchase plan,
                  each as in effect on the date of this Agreement; and (iii) for
                  the issuance by the Company of shares of Common Stock in
                  connection with a merger with or acquisition of a corporation
                  or entity that is not an affiliate of the Company or an
                  acquisition of the assets or property of a corporation or
                  entity that is not an affiliate of the Company; provided,
                  however, that the Company shall cause the holder of any
                  securities acquired pursuant to the exceptions in clauses (i),
                  (ii) and, where practicable, (iii) to furnish to the
                  Underwriters a Lockup Agreement (as defined below).

         (j)      The Company will use its best efforts to list, subject to
                  notice of issuance, the Shares on the Nasdaq Stock Market.

         (k)      The Company has caused each officer and director, shareholder,
                  optionholder and warrant holder of the Company to furnish to
                  you, on or prior to the date of this Agreement, a letter or
                  letters, in form and substance satisfactory to the
                  Underwriters, pursuant to which each such person agrees not to
                  offer, sell, sell short or otherwise dispose of any shares of
                  Common Stock of the Company or other capital stock of the
                  Company, or any other securities convertible, exchangeable or
                  exercisable for Common Shares or derivative of Common Shares
                  owned by such person (or as to which such person has the right
                  to direct the disposition of) or request the registration for
                  the offer or sale of any of the foregoing for a period of 180
                  days after the date of this Agreement, directly or indirectly,
                  except with the prior written consent of Deutsche Bank
                  Securities Inc. (the "Lockup Agreements").


                                      15
<PAGE>


         (l)      The Company shall apply the net proceeds of its sale of the
                  Shares as set forth in the Prospectus and shall file such
                  reports with the Commission with respect to the sale of the
                  Shares and the application of the proceeds therefrom as may be
                  required in accordance with Rule 463 under the Act.

         (m)      The Company shall not invest, or otherwise use the proceeds
                  received by the Company from its sale of the Shares in such a
                  manner as would require the Company to register as an
                  investment company under the 1940 Act.

         (n)      The Company will maintain a transfer agent and, if necessary
                  under the jurisdiction of incorporation of the Company, a
                  registrar for the Common Stock.

         (o)      The Company will not take, directly or indirectly, any action
                  designed to cause or result in, or that has constituted or
                  might reasonably be expected to constitute, the stabilization
                  or manipulation of the price of any securities of the Company.

(5)      COSTS AND EXPENSES.

         The Company will pay all costs, expenses and fees incident to the
performance of the obligations of the Company under this Agreement, including,
without limiting the generality of the foregoing, the following: accounting fees
of the Company; the fees and disbursements of counsel for the Company; the cost
of printing and delivering to, or as requested by, the Underwriters copies of
the Registration Statement, Preliminary Prospectuses, the Prospectus, this
Agreement, the Underwriters' Selling Memorandum, if any, the Underwriters'
Invitation Letter, the Listing Application, the Blue Sky Survey and any
supplements or amendments thereto; the filing fees of the Commission; the filing
fees and expenses (including legal fees and disbursements) incident to securing
any required review by the NASD of the terms of the sale of the Shares; the
Listing Fee of the Nasdaq Stock Market; and the expenses, including the fees and
disbursements of counsel for the Underwriters, incurred in connection with the
qualification of the Shares under state securities or blue sky laws. Any
transfer taxes imposed on the sale of the Shares to the several Underwriters
will be paid by the Company. The Company agrees to pay all costs and expenses of
the Underwriters, including the fees and disbursements of counsel for the
Underwriters, incident to the offer and sale of the Reserved Shares. The Company
shall not, however, be required to pay for any of the Underwriters' expenses
(other than those related to qualification under NASD regulation and state
securities or blue sky laws) except that, if this Agreement shall not be
consummated because the conditions in Section 6 hereof are not satisfied, or
because this Agreement is terminated by the Representatives pursuant to Section
11 hereof, or by reason of any failure, refusal or inability on the part of the
Company to perform any undertaking or satisfy any condition of this Agreement or
to comply with any of the terms hereof on its part to be performed, unless such
failure to satisfy said condition or to comply with said terms be due to the
default or omission of any Underwriter, then the Company shall reimburse the
several Underwriters for reasonable out-of-pocket expenses, including fees and
disbursements of counsel, reasonably incurred in connection with investigating,
marketing and proposing to market the Shares or in contemplation of performing
their obligations hereunder; but the Company shall not in any



                                      16
<PAGE>


event be liable to any of the several Underwriters for damages on account of
loss of anticipated profits from the sale by them of the Shares.

(6)      CONDITIONS OF OBLIGATIONS OF THE UNDERWRITERS.

         The several obligations of the Underwriters to purchase the Firm Shares
on the Closing Date and the Option Shares, if any, on the Option Closing Date
are subject to the accuracy, as of the Closing Date or the Option Closing Date,
as the case may be, of the representations and warranties of the Company
contained herein, and to the performance by the Company of its covenants and
obligations hereunder and to the following additional conditions:

         (a)      The Registration Statement and all post-effective amendments
                  thereto shall have become effective and any and all filings
                  required by Rule 424 and Rule 430A of the Rules and
                  Regulations shall have been made, and any request of the
                  Commission for additional information (to be included in the
                  Registration Statement or otherwise) shall have been disclosed
                  to the Representatives and complied with to their reasonable
                  satisfaction. No stop order suspending the effectiveness of
                  the Registration Statement, as amended from time to time,
                  shall have been issued and no proceedings for that purpose
                  shall have been taken or, to the knowledge of the Company,
                  shall be contemplated by the Commission and no injunction,
                  restraining order, or order of any nature by a federal or
                  state court of competent jurisdiction shall have been issued
                  as of the Closing Date or the Option Closing Date, as the case
                  may be, which would prevent the issuance of the Shares. The
                  NASD shall have confirmed that it will not raise any objection
                  to the fairness and reasonableness of the underwriting terms
                  and arrangements.

         (b)      The Representatives shall have received on the Closing Date or
                  the Option Closing Date, as the case may be, the opinion of
                  Palmer & Dodge LLP, counsel for the Company, dated the Closing
                  Date or the Option Closing Date, as the case may be, addressed
                  to the Underwriters (and stating that it may be relied upon by
                  counsel to the Underwriters) to the effect that:

                  (i)      The Company is a corporation validly existing and in
                           good standing under the laws of the State of
                           Delaware, with corporate power and authority to own
                           or lease its properties and conduct its business as
                           described in the Registration Statement; the Company
                           is duly qualified to transact business in the State
                           of Connecticut.

                  (ii)     The Company has authorized and outstanding capital
                           stock as set forth under the caption "Capitalization"
                           in the Prospectus; the authorized shares of the
                           Company's Common Stock have been duly authorized; the
                           outstanding shares of the Company's Common Stock have
                           been duly authorized and validly issued and are fully
                           paid and non-assessable; all of the Shares conform to
                           the description thereof contained in the Prospectus;
                           the certificates for the Shares, assuming they are in
                           the form


                                      17
<PAGE>

                           filed with the Commission, are in due and proper
                           form; the shares of Common Stock, including the
                           Option Shares, if any, to be sold by the Company
                           pursuant to this Agreement have been duly
                           authorized and will be validly issued, fully paid
                           and non-assessable when issued and paid for as
                           contemplated by this Agreement; and no preemptive
                           rights of stockholders exist with respect to any
                           of the Shares or the issue or sale thereof.

                  (iii)    Except as described in or contemplated by the
                           Prospectus, to the knowledge of such counsel there
                           are no outstanding securities of the Company
                           convertible or exchangeable into or evidencing the
                           right to purchase or subscribe for any shares of
                           capital stock of the Company and there are no
                           outstanding or authorized options, warrants or rights
                           of any character obligating the Company to issue any
                           shares of its capital stock or any securities
                           convertible or exchangeable into or evidencing the
                           right to purchase or subscribe for any shares of such
                           stock; and except as described in the Prospectus, to
                           the knowledge of such counsel, no holder of any
                           securities of the Company or any other person has the
                           right, contractual or otherwise, which has not been
                           satisfied or effectively waived, to cause the Company
                           to sell or otherwise issue to them, or to permit them
                           to underwrite the sale of, any of the Shares or the
                           right to have any Common Shares or other securities
                           of the Company included in the Registration Statement
                           or the right, as a result of the filing of the
                           Registration Statement, to require registration under
                           the Act of any shares of Common Stock or other
                           securities of the Company.

                  (iv)     The Registration Statement has become effective under
                           the Act and, to the best knowledge of such counsel,
                           no stop order proceedings with respect thereto have
                           been instituted or are pending or threatened under
                           the Act.

                  (v)      The Registration Statement, the Prospectus and each
                           amendment or supplement thereto comply as to form in
                           all material respects with the requirements of the
                           Act and the applicable rules and regulations
                           thereunder (except that such counsel need express no
                           opinion as to the financial statements and schedules
                           and notes therein). For the purpose of passing upon
                           the form of such documents, we have not independently
                           verified and are not passing upon, and have assumed
                           the correctness and completeness of, the statements
                           made therein.

                  (vi)     The statements in the Prospectus under the captions
                           "Management -- Employee Benefits Plans," "Certain
                           Relationships and Related Party Transactions,"
                           "Description of Capital Stock" and "Shares Eligible
                           for Future Sale," in each case insofar as such
                           statements constitute a summary of documents referred
                           to therein or matters of law, fairly summarize in all
                           material respects the information called for with
                           respect to such documents and matters.


                                      18
<PAGE>


                  (vii)    Such counsel does not know of any contracts or
                           documents required to be filed as exhibits to the
                           Registration Statement or described in the
                           Registration Statement or the Prospectus which are
                           not so filed or described as required, and such
                           contracts and documents as are summarized in the
                           Registration Statement or the Prospectus are fairly
                           summarized in all material respects.

                  (viii)   To such counsel's knowledge, there is no material
                           legal or governmental proceedings pending or
                           threatened against the Company except as described in
                           the Prospectus.

                  (ix)     The execution and delivery of this Agreement and the
                           consummation of the transactions herein contemplated
                           do not and will not conflict with or result in a
                           breach of any of the terms or provisions of, or
                           constitute a default under, the charter or by-laws of
                           the Company, or any material agreement or instrument
                           filed as an exhibit to the Registration Statement to
                           which the Company is a party or by which the Company
                           is bound.

                  (x)      This Agreement has been duly authorized, executed and
                           delivered by the Company.

                  (xi)     No approval, consent, order, authorization,
                           designation, declaration or filing by or with any
                           regulatory, administrative or other governmental body
                           is necessary in connection with the execution and
                           delivery of this Agreement and the consummation of
                           the transactions herein contemplated (other than as
                           may be required by the NASD or as required by foreign
                           securities and state securities and blue sky laws, as
                           to which such counsel need express no opinion) except
                           such as have been obtained or made.

                  (xii)    The Company is not, and will not become, as a result
                           of the consummation of the transactions contemplated
                           by this Agreement, and application of the net
                           proceeds therefrom as described in the Prospectus,
                           required to register as an investment company under
                           the 1940 Act.

         In rendering such opinion Palmer & Dodge LLP may rely as to matters
governed by the laws of states other than the Commonwealth of Massachusetts, the
General Corporation Law of the State of Delaware or federal laws on local
counsel in such jurisdictions, provided that in each case Palmer & Dodge LLP
shall state that they believe that they and the Underwriters are justified in
relying on such other counsel. In addition to the matters set forth above, such
opinion shall also include a statement to the effect that nothing has come to
the attention of such counsel which leads them to believe that (i) the
Registration Statement, at the time it became effective under the Act (but after
giving effect to any modifications incorporated therein pursuant to Rule 430A
under the Act) and as of the Closing Date or the Option Closing Date, as the
case may be, contained an untrue statement of a material fact or omitted to
state a material fact required to be stated therein or necessary to make the



                                      19
<PAGE>

statements therein not misleading, and (ii) the Prospectus, or any supplement
thereto, on the date it was filed pursuant to the Rules and Regulations and as
of the Closing Date or the Option Closing Date, as the case may be, contained an
untrue statement of a material fact or omitted to state a material fact
necessary in order to make the statements, in the light of the circumstances
under which they are made, not misleading (except that such counsel need express
no view as to financial statements, schedules and statistical information
therein). With respect to such statement, Palmer & Dodge LLP may state that
their belief is based upon the procedures set forth therein, but is without
independent check and verification.

         (c)      The Representatives shall have received from Ropes & Gray,
                  counsel for the Underwriters, an opinion dated the Closing
                  Date or the Option Closing Date, as the case may be, with
                  respect to the incorporation of the Company, the validity of
                  the Shares delivered on the Closing Date or the Option Closing
                  Date, as the case may be, the Registration Statement, the
                  Prospectus and other related matters as the Representatives
                  may require, and the Company shall have furnished to such
                  counsel such documents as they request for the purpose of
                  enabling them to pass upon such matters. In rendering such
                  opinion, Ropes & Gray may rely as to all matters governed
                  other than by the laws of the Commonwealth of Massachusetts,
                  the General Corporation Law of the State of Delaware, or
                  federal laws on the opinion of counsel referred to in
                  Paragraph (b) of this Section 6. In addition to the matters
                  set forth above, such opinion shall also include a statement
                  to the effect that nothing has come to the attention of such
                  counsel which leads them to believe that (i) the Registration
                  Statement, or any amendment thereto, as of the time it became
                  effective under the Act (but after giving effect to any
                  modifications incorporated therein pursuant to Rule 430A under
                  the Act) as of the Closing Date or the Option Closing Date, as
                  the case may be, contained an untrue statement of a material
                  fact or omitted to state a material fact required to be stated
                  therein or necessary to make the statements therein not
                  misleading, and (ii) the Prospectus, or any supplement
                  thereto, on the date it was filed pursuant to the Rules and
                  Regulations and as of the Closing Date or the Option Closing
                  Date, as the case may be, contained an untrue statement of a
                  material fact or omitted to state a material fact, necessary
                  in order to make the statements, in the light of the
                  circumstances under which they are made, not misleading
                  (except that such counsel need express no view as to financial
                  statements, schedules and statistical information therein).
                  With respect to such statement, Ropes & Gray may state that
                  their belief is based upon the procedures set forth therein,
                  but is without independent check and verification.

         (d)      The Representatives shall have received at or prior to the
                  Closing Date from Ropes & Gray a memorandum or summary, in
                  form and substance satisfactory to the Representatives, with
                  respect to the qualification for offering and sale by the
                  Underwriters of the Shares under the state securities or blue
                  sky laws of such jurisdictions as the Representatives may
                  reasonably have designated to the Company.

         (e)      You shall have received, on each of the dates hereof, the
                  Closing Date and the Option Closing Date, as the case may be,
                  a letter dated the date hereof, the


                                      20
<PAGE>

                  Closing Date or the Option Closing Date, as the case may
                  be, in form and substance satisfactory to you, of Arthur
                  Andersen LLP confirming that they are independent public
                  accountants within the meaning of the Act and the
                  applicable Rules and Regulations thereunder and stating
                  that in their opinion the financial statements and
                  schedules examined by them and included in the Registration
                  Statement comply in form in all material respects with the
                  applicable published accounting requirements of the Act and
                  the related published Rules and Regulations; and containing
                  such other statements and information as is ordinarily
                  included in accountants' "comfort letters" to Underwriters
                  with respect to the financial statements and certain
                  financial and statistical information contained in the
                  Registration Statement and Prospectus.

         (f)      The Representatives shall have received on the Closing Date or
                  the Option Closing Date, as the case may be, a certificate or
                  certificates of the Chief Executive Officer and the Chief
                  Financial Officer of the Company to the effect that, as of the
                  Closing Date or the Option Closing Date, as the case may be,
                  each of them severally represents on behalf of the Company as
                  follows:

                  (i)      The Registration Statement has become effective under
                           the Act and no stop order suspending the
                           effectiveness of the Registration Statement has been
                           issued, and no proceedings for such purpose have been
                           taken or are, to his knowledge, contemplated by the
                           Commission;

                  (ii)     The representations and warranties of the Company
                           contained in Section 1 hereof are true and correct as
                           of the Closing Date or the Option Closing Date, as
                           the case may be;

                  (iii)    All filings required to have been made pursuant to
                           Rules 424 or 430A under the Act have been made;

                  (iv)     The Company has complied with all the agreements and
                           satisfied all the conditions on its part to be
                           performed or satisfied at or prior to such closing
                           date;

                  (v)      He has examined the Registration Statement and the
                           Prospectus and, in his opinion, as of the effective
                           date of the Registration Statement, the statements
                           contained in the Registration Statement were true and
                           correct, and such Registration Statement and
                           Prospectus did not omit to state a material fact
                           required to be stated therein or necessary in order
                           to make the statements therein not misleading, and
                           since the effective date of the Registration
                           Statement, no event has occurred which should have
                           been set forth in a supplement to or an amendment of
                           the Prospectus which has not been so set forth in
                           such supplement or amendment; and

                  (vi)     Since the respective dates as of which information is
                           given in the Registration Statement and Prospectus,
                           there has not been any material adverse change or any
                           development involving a prospective material


                                       21
<PAGE>

                           adverse change in or affecting the condition,
                           financial or otherwise, of the Company or the
                           earnings, business, management, properties, assets,
                           rights, operations, condition (financial or
                           otherwise) or prospects of the Company, whether or
                           not arising in the ordinary course of business.

         (g)      On each of the Closing Date and the Option Closing Date, if
                  any, the Representatives shall have received a certificate or
                  certificates of the Secretary of the Company in form and
                  substance reasonably satisfactory to the Representatives.

         (h)      The Company shall have furnished to the Representatives such
                  further certificates and documents confirming the
                  representations and warranties, covenants and conditions
                  contained herein and related matters as the Representatives
                  may reasonably have requested.

         (i)      The Firm Shares and Option Shares, if any, have been approved
                  for designation upon notice of issuance on the Nasdaq Stock
                  Market.

         (j)      The Lockup Agreements described in Section 4(k) shall be in
                  full force and effect.

         (k)      The Representatives shall have received from the Company's
                  outside patent counsel an opinion dated the Closing Date or
                  the Option Closing Date, as the case may be, in substantially
                  the form attached as Exhibit B.

         (l)      The Representatives shall have received from the Company's
                  Director of Intellectual Property, an opinion dated the
                  Closing Date or the Option Closing Date, as the case may be,
                  in substantially the form attached as Exhibit C.

         (m)      The Representatives shall have received from Venable, Baetjer,
                  Howard & Civiletti, LLP, special regulatory counsel to the
                  Company, an opinion dated the Closing Date or the Option
                  Closing Date, as the case may be, to the effect that:

                 (i)    Such counsel represents the Company in certain matters
                        relating to the Unites States Federal Food Drug, and
                        Cosmetic Act (the "FFDC Act") and related government
                        regulatory matters. Such counsel has made such
                        investigations of fact and law as such counsel deemed
                        necessary in connection with the opinion set
                        forth below.

                 (ii)   Based upon and subject to the foregoing, and subject
                        to the additional qualifications, exclusions,
                        exceptions, limitations and assumptions set forth
                        herein, such counsel is of the opinion that the
                        portions of the Registration Statement and Prospectus
                        entitled "Risk Factors -- Our business and the
                        products, if any,... are subject to government
                        regulation...," and "Business-Government Regulation,"
                        insofar as they describe the FFDC Act, related
                        government regulatory matters and FDA regulations and
                        requirements and the application thereof to the


                                       22
<PAGE>

                        Company's business and operations (collectively, the
                        "Regulatory Portion"), are accurate and complete
                        summaries and fairly present in all material respects
                        such matters.

                (iii)   In addition to rendering the foregoing opinion, such
                        counsel confirms that such counsel has participated
                        in conferences with certain officers and
                        representatives of the Company, representatives of
                        the independent accountants for the Company, counsel
                        for the Underwriters and representatives of the
                        Underwriters in which the contents of the
                        Registration Statement and Prospectus and related
                        matters were discussed and that, while such counsel
                        is not passing upon and do not assume responsibility
                        for the factual accuracy, completeness or fairness of
                        the statements contained in the Registration
                        Statement and Prospectus, nothing has come to such
                        counsel's attention that would lead such counsel to
                        believe (A) that the Regulatory Portion included
                        therein at the time the Registration Statement became
                        effective contained any untrue statement of a
                        material fact or omitted to state a material fact
                        required to be stated therein or necessary to make
                        the statements therein not misleading and (B) that
                        the Regulatory Portion contains any untrue statement
                        of a material fact or omits to state a material fact
                        necessary in order to make the statements therein, in
                        the light of the circumstances under which they were
                        made, not misleading.

         With respect to paragraph (iii) above, counsel may state that its
belief is based upon its participation in the preparation of the Registration
Statement and Prospectus (and any amendments or supplements thereto), review and
discussion of the contents thereof (including the review of, but not
participation in the preparation of, the documents incorporated by reference
therein), but are without independent check or verification except as specified.
In addition, with respect to factual matters addressed in the Regulatory
Portion, counsel may state that it has relied upon one or more factual
certificates from representatives of the Company, PROVIDED that such statement
is accompanied by a statement to the effect that nothing has come to the
attention of counsel to cause such counsel to believe that the representations
made in such certificate(s) are not true, complete and correct in all material
respects.

         The opinions and certificates mentioned in this Agreement shall be
deemed to be in compliance with the provisions hereof only if they are in all
material respects reasonably satisfactory to the Representatives and to Ropes &
Gray, counsel for the Underwriters.

         If any of the conditions hereinabove provided for in this Section 6
shall not have been fulfilled when and as required by this Agreement to be
fulfilled, the obligations of the Underwriters hereunder may be terminated by
the Representatives by notifying the Company of such termination in writing or
by telegram at or prior to the Closing Date or the Option Closing Date, as the
case may be.

         In such event, the Company and the Underwriters shall not be under any
obligation to each other (except to the extent provided in Sections 5 and 8
hereof).


                                       23
<PAGE>

(7)      CONDITIONS OF THE OBLIGATIONS OF THE COMPANY.

         The obligation of the Company to sell and deliver the portion of the
Shares required to be delivered as and when specified in this Agreement are
subject to the conditions that at the Closing Date or the Option Closing Date,
as the case may be, no stop order suspending the effectiveness of the
Registration Statement shall have been issued and in effect or proceedings
therefor initiated or threatened.

(8)      INDEMNIFICATION.

         (a)      The Company agrees:

                  (1)      to indemnify and hold harmless each Underwriter and
                           each person, if any, who controls any Underwriter
                           within the meaning of the Act, against any losses,
                           claims, damages or liabilities to which such
                           Underwriter or any such controlling person may become
                           subject under the Act or otherwise, insofar as such
                           losses, claims, damages or liabilities (or actions or
                           proceedings in respect thereof) arise out of or are
                           based upon (i) any untrue statement or alleged untrue
                           statement of any material fact contained in the
                           Registration Statement, any Preliminary Prospectus,
                           the Prospectus or any amendment or supplement
                           thereto, (ii) the omission or alleged omission to
                           state therein a material fact required to be stated
                           therein or necessary to make the statements therein
                           not misleading, (iii) the violation of any applicable
                           laws or regulations of foreign jurisdictions where
                           Reserved Shares have been offered to persons
                           designated by the Company as a result of such offer
                           or sale of Reserved Shares, or (iv) any act or
                           failure to act or any alleged act or failure to act
                           by any Underwriter in connection with, or relating in
                           any manner to, the Shares or the offering
                           contemplated hereby, and which is included as part of
                           or referred to in any loss, claim, damage, liability
                           or action arising out of or based upon matters
                           covered by clause (i) or (ii) above (PROVIDED, that
                           the Company shall not be liable under this clause
                           (iv) to the extent that it is determined in a final
                           judgment by a court of competent jurisdiction that
                           such loss, claim, damage, liability or action
                           resulted directly from any such acts or failures to
                           act undertaken or omitted to be taken by such
                           Underwriter through its gross negligence or willful
                           misconduct); provided, however, that (i) the Company
                           will not be liable in any such case to the extent
                           that any such loss, claim, damage or liability arises
                           out of or is based upon an untrue statement or
                           alleged untrue statement, or omission or alleged
                           omission made in the Registration Statement, any
                           Preliminary Prospectus, the Prospectus, or such
                           amendment or supplement, in reliance upon and in
                           conformity with written information furnished to the
                           Company by or through the Representatives
                           specifically for use in the preparation thereof, and
                           (ii) the indemnity agreement contained in this
                           Section (a) (1) with respect to any Preliminary
                           Prospectus or Prospectus shall not inure to the
                           benefit of any Underwriter from whom


                                       24
<PAGE>

                           the person asserting any such losses, claims,
                           damages, liabilities or expenses purchased the
                           Shares which is the subject thereof (or to the
                           benefit of any person controlling such Underwriter)
                           if at or prior to the written confirmation of the
                           sale of such Shares a copy of the Prospectus (or the
                           Prospectus as amended  or supplemented) was not sent
                           or delivered to such person, if required by law so to
                           have been delivered, and the untrue statement or
                           omission of a material fact contained in such
                           Preliminary Prospectus or Prospectus was corrected in
                           the Prospectus (or the Prospectus as amended or
                           supplemented).

                  (2)      to reimburse each Underwriter and each such
                           controlling person upon demand for any legal or other
                           out-of-pocket expenses reasonably incurred by such
                           Underwriter or such controlling person in connection
                           with investigating or defending any such loss, claim,
                           damage or liability, action or proceeding or in
                           responding to a subpoena or governmental inquiry
                           related to the offering of the Shares, whether or not
                           such Underwriter or controlling person is a party to
                           any action or proceeding. In the event that it is
                           finally judicially determined that the Underwriters
                           were not entitled to receive payments for legal and
                           other expenses pursuant to this subparagraph, the
                           Underwriters will promptly return all sums that had
                           been advanced pursuant hereto.

         (b)      Each Underwriter severally and not jointly will indemnify and
                  hold harmless the Company, each of its directors, each of its
                  officers who have signed the Registration Statement and each
                  person, if any, who controls the Company within the meaning of
                  the Act, against any losses, claims, damages or liabilities to
                  which the Company or any such director, officer, or
                  controlling person may become subject under the Act or
                  otherwise, insofar as such losses, claims, damages or
                  liabilities (or actions or proceedings in respect thereof)
                  arise out of or are based upon (i) any untrue statement or
                  alleged untrue statement of any material fact contained in the
                  Registration Statement, any Preliminary Prospectus, the
                  Prospectus or any amendment or supplement thereto, or (ii) the
                  omission or the alleged omission to state therein a material
                  fact required to be stated therein or necessary to make the
                  statements therein not misleading in the light of the
                  circumstances under which they were made; and will reimburse
                  any legal or other expenses reasonably incurred by the Company
                  or any such director, officer, or controlling person in
                  connection with investigating or defending any such loss,
                  claim, damage, liability, action or proceeding; provided,
                  however, that each Underwriter will be liable in each case to
                  the extent, but only to the extent, that such untrue statement
                  or alleged untrue statement or omission or alleged omission
                  has been made in the Registration Statement, any Preliminary
                  Prospectus, the Prospectus or such amendment or supplement, in
                  reliance upon and in conformity with written information
                  furnished to the Company by or through the Representatives
                  specifically for use in the preparation thereof. This
                  indemnity agreement will be in addition to any liability which
                  such Underwriter may otherwise have.


                                       25

<PAGE>

         (c)      In case any proceeding (including any governmental
                  investigation) shall be instituted involving any person in
                  respect of which indemnity may be sought pursuant to this
                  Section 8, such person (the "indemnified party") shall
                  promptly notify the person against whom such indemnity may be
                  sought (the "indemnifying party") in writing. No
                  indemnification provided for in Section 8(a) or (b) shall be
                  available to any party who shall fail to give notice as
                  provided in this Section 8(c) if the party to whom notice was
                  not given was unaware of the proceeding to which such notice
                  would have related and was materially prejudiced by the
                  failure to give such notice, but the failure to give such
                  notice shall not relieve the indemnifying party or parties
                  from any liability which it or they may have to the
                  indemnified party for contribution or otherwise than on
                  account of the provisions of Section 8(a) or (b). In case any
                  such proceeding shall be brought against any indemnified party
                  and it shall notify the indemnifying party of the commencement
                  thereof, the indemnifying party shall be entitled to
                  participate therein and, to the extent that it shall wish,
                  jointly with any other indemnifying party similarly notified,
                  to assume the defense thereof, with counsel satisfactory to
                  such indemnified party and shall pay as incurred the fees and
                  disbursements of such counsel related to such proceeding. In
                  any such proceeding, any indemnified party shall have the
                  right to retain its own counsel at its own expense.
                  Notwithstanding the foregoing, the indemnifying party shall
                  pay as incurred (or within 30 days of presentation) the fees
                  and expenses of the counsel retained by the indemnified party
                  in the event (i) the indemnifying party and the indemnified
                  party shall have mutually agreed to the retention of such
                  counsel, (ii) the named parties to any such proceeding
                  (including any impleaded parties) include both the
                  indemnifying party and the indemnified party and
                  representation of both parties by the same counsel would be
                  inappropriate due to actual or potential differing interests
                  between them, or (iii) the indemnifying party shall have
                  failed to assume the defense and employ counsel acceptable to
                  the indemnified party within a reasonable period of time after
                  notice of commencement of the action. It is understood that
                  the indemnifying party shall not, in connection with any
                  proceeding or related proceedings in the same jurisdiction, be
                  liable for the reasonable fees and expenses of more than one
                  separate firm for all such indemnified parties. Such firm
                  shall be designated in writing by you in the case of parties
                  indemnified pursuant to Section 8(a) and by the Company in the
                  case of parties indemnified pursuant to Section 8(b). The
                  indemnifying party shall not be liable for any settlement of
                  any proceeding effected without its written consent but if
                  settled with such consent or if there be a final judgment for
                  the plaintiff, the indemnifying party agrees to indemnify the
                  indemnified party from and against any loss or liability by
                  reason of such settlement or judgment. In addition, the
                  indemnifying party will not, without the prior written consent
                  of the indemnified party, settle or compromise or consent to
                  the entry of any judgment in any pending or threatened claim,
                  action or proceeding of which indemnification may be sought
                  hereunder (whether or not any indemnified party is an actual
                  or potential party to such claim, action or proceeding) unless
                  such settlement, compromise or consent includes an
                  unconditional release of each


                                       26
<PAGE>

                  indemnified party from all liability arising out of such
                  claim, action or proceeding.

         (d)      If the indemnification provided for in this Section 8 is
                  unavailable to or insufficient to hold harmless an indemnified
                  party under Section 8(a) or (b) above in respect of any
                  losses, claims, damages or liabilities (or actions or
                  proceedings in respect thereof) referred to therein, then each
                  indemnifying party shall contribute to the amount paid or
                  payable by such indemnified party as a result of such losses,
                  claims, damages or liabilities (or actions or proceedings in
                  respect thereof) in such proportion as is appropriate to
                  reflect the relative benefits received by the Company on the
                  one hand and the Underwriters on the other from the offering
                  of the Shares; provided, however, no contribution under this
                  Section 8(d) is required if the indemnification provided for
                  in Section 8(a) or (b) were not available by reason of the
                  exceptions and limitations set forth therein. If, however, the
                  allocation provided by the immediately preceding sentence is
                  not permitted by applicable law then each indemnifying party
                  shall contribute to such amount paid or payable by such
                  indemnified party in such proportion as is appropriate to
                  reflect not only such relative benefits but also the relative
                  fault of the Company on the one hand and the Underwriters on
                  the other in connection with the statements or omissions which
                  resulted in such losses, claims, damages or liabilities (or
                  actions or proceedings in respect thereof), as well as any
                  other relevant equitable considerations. The relative benefits
                  received by the Company on the one hand and the Underwriters
                  on the other shall be deemed to be in the same proportion as
                  the total net proceeds from the offering (before deducting
                  expenses) received by the Company bear to the total
                  underwriting discounts and commissions received by the
                  Underwriters, in each case as set forth in the table on the
                  cover page of the Prospectus. The relative fault shall be
                  determined by reference to, among other things, whether the
                  untrue or alleged untrue statement of a material fact or the
                  omission or alleged omission to state a material fact relates
                  to information supplied by the Company on the one hand or the
                  Underwriters on the other and the parties' relative intent,
                  knowledge, access to information and opportunity to correct or
                  prevent such statement or omission.

         The Company and the Underwriters agree that it would not be just and
equitable if contributions pursuant to this Section 8(d) were determined by pro
rata allocation (even if the Underwriters were treated as one entity for such
purpose) or by any other method of allocation which does not take account of the
equitable considerations referred to above in this Section 8(d). The amount paid
or payable by an indemnified party as a result of the losses, claims, damages or
liabilities (or actions or proceedings in respect thereof) referred to above in
this Section 8(d) shall be deemed to include any legal or other expenses
reasonably incurred by such indemnified party in connection with investigating
or defending any such action or claim. Notwithstanding the provisions of this
subsection (d), (i) no Underwriter shall be required to contribute any amount in
excess of the underwriting discounts and commissions applicable to the Shares
purchased by such Underwriter, and (ii) no person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Act) shall be
entitled to contribution from any person who was not guilty of such fraudulent
misrepresentation. The


                                       27
<PAGE>

Underwriters' obligations in this Section 8(d) to contribute are several in
proportion to their respective underwriting obligations and not joint.

         (e)      In any proceeding relating to the Registration Statement, any
                  Preliminary Prospectus, the Prospectus or any supplement or
                  amendment thereto, each party against whom contribution may be
                  sought under this Section 8 hereby consents to the
                  jurisdiction of any court having jurisdiction over any other
                  contributing party, agrees that process issuing from such
                  court may be served upon him or it by any other contributing
                  party and consents to the service of such process and agrees
                  that any other contributing party may join him or it as an
                  additional defendant in any such proceeding in which such
                  other contributing party is a party.

         (f)      Any losses, claims, damages, liabilities or expenses for which
                  an indemnified party is entitled to indemnification or
                  contribution under this Section 8 shall be paid by the
                  indemnifying party to the indemnified party as such losses,
                  claims, damages, liabilities or expenses are incurred. The
                  indemnity and contribution agreements contained in this
                  Section 8 and the representations and warranties of the
                  Company set forth in this Agreement shall remain operative and
                  in full force and effect, regardless of (i) any investigation
                  made by or on behalf of any Underwriter or any person
                  controlling any Underwriter, the Company, its directors or
                  officers or any persons controlling the Company, (ii)
                  acceptance of any Shares and payment therefor hereunder, and
                  (iii) any termination of this Agreement. A successor to any
                  Underwriter, or to the Company, its directors or officers, or
                  any person controlling the Company, shall be entitled to the
                  benefits of the indemnity, contribution and reimbursement
                  agreements contained in this Section 8.

         (g)      In connection with the offer and sale of the Reserved Shares,
                  the Company agrees, promptly upon a request in writing, to
                  indemnify and hold harmless the Underwriters from and against
                  any and all losses, liabilities, claims, damages and expenses
                  incurred by them as a result of the failure of persons
                  designated by the Company to pay for and accept delivery of
                  Reserved Shares which, by the end of the first business day
                  following the date of this Agreement, were subject to a
                  properly confirmed agreement to purchase.

(9)      DEFAULT BY UNDERWRITERS.

         If on the Closing Date or the Option Closing Date, as the case may be,
any Underwriter shall fail to purchase and pay for the portion of the Shares
which such Underwriter has agreed to purchase and pay for on such date
(otherwise than by reason of any default on the part of the Company), you, as
Representatives of the Underwriters, shall use your reasonable efforts to
procure within 36 hours thereafter one or more of the other Underwriters, or any
others, to purchase from the Company such amounts as may be agreed upon and upon
the terms set forth herein, the Firm Shares or Option Shares, as the case may
be, which the defaulting Underwriter or Underwriters failed to purchase. If
during such 36 hours you, as such Representatives, shall not have procured such
other Underwriters, or any


                                       28
<PAGE>

others, to purchase the Firm Shares or Option Shares, as the case may be,
agreed to be purchased by the defaulting Underwriter or Underwriters, then
(a) if the aggregate number of shares with respect to which such default
shall occur does not exceed 10% of the Firm Shares or Option Shares, as the
case may be, covered hereby, the other Underwriters shall be obligated,
severally, in proportion to the respective numbers of Firm Shares or Option
Shares, as the case may be, which they are obligated to purchase hereunder,
to purchase the Firm Shares or Option Shares, as the case may be, which such
defaulting Underwriter or Underwriters failed to purchase, or (b) if the
aggregate number of shares of Firm Shares or Option Shares, as the case may
be, with respect to which such default shall occur exceeds 10% of the Firm
Shares or Option Shares, as the case may be, covered hereby, the Company or
you, as the Representatives of the Underwriters, will have the right, by
written notice given within the next 36-hour period to the parties to this
Agreement, to terminate this Agreement without liability on the part of the
non-defaulting Underwriters or of the Company except to the extent provided
in Section 8 hereof. In the event of a default by any Underwriter or
Underwriters as set forth in this Section 9, the Closing Date or Option
Closing Date, as the case may be, may be postponed for such period, not
exceeding seven days, as you, as Representatives, may determine in order that
the required changes in the Registration Statement or in the Prospectus or in
any other documents or arrangements may be effected. The term "Underwriter"
includes any person substituted for a defaulting Underwriter. Any action
taken under this Section 9 shall not relieve any defaulting Underwriter from
liability in respect of any default of such Underwriter under this Agreement.

(10)     NOTICES.

         All communications hereunder shall be in writing and, except as
otherwise provided herein, will be mailed, delivered, telecopied or telegraphed
and confirmed as follows: if to the Underwriters, to Deutsche Bank Securities
Inc., One South Street, Baltimore, Maryland 21202, Attention: Brent B. Milner;
with a copy to Deutsche Bank Securities Inc., One Bankers Trust Plaza, 130
Liberty Street, New York, New York 10006, Attention: General Counsel; if to the
Company, to Genaissance Pharmaceuticals, Inc. (5 Science Park, New Haven,
Connecticut 06511), Attention: President; with a copy to Palmer & Dodge LLP, One
Beacon Street, Boston, Massachusetts 02108, Attention: Michael Lytton, Esq.

(11)     TERMINATION. This Agreement may be terminated:

         (a)      by you by notice to the Company at any time prior to the
                  Closing Date if any of the following has occurred: (i) since
                  the respective dates as of which information is given in the
                  Registration Statement and the Prospectus, any material
                  adverse change or any development involving a prospective
                  material adverse change in or affecting the condition,
                  financial or otherwise, of the Company or the earnings,
                  business, management, properties, assets, rights, operations,
                  condition (financial or otherwise) or prospects of the
                  Company, whether or not arising in the ordinary course of
                  business, (ii) any outbreak or escalation of hostilities or
                  declaration of war or national emergency or other national or
                  international calamity or crisis or change in economic or
                  political conditions if the effect of such outbreak,
                  escalation, declaration, emergency, calamity, crisis or change
                  on the financial markets of the United States would,


                                       29
<PAGE>

                  in your reasonable judgment, make it impracticable or
                  inadvisable to market the Shares or to enforce contracts
                  for the sale of the Shares, or (iii) suspension of trading
                  in securities generally on the New York Stock Exchange or
                  the American Stock Exchange or the limitation on prices
                  (other than limitations on hours or numbers of days of
                  trading) for securities on either such Exchange, (iv) the
                  enactment, publication, decree or other promulgation of any
                  statute, regulation, rule or order of any court or other
                  governmental authority which in your reasonable opinion
                  materially and adversely affects or may materially and
                  adversely affect the business or operations of the Company,
                  (v) declaration of a banking moratorium by United States or
                  New York State authorities, (vi) any downgrading, or
                  placement on any watch list for possible downgrading, in
                  the rating of the Company's debt securities by any
                  "nationally recognized statistical rating organization" (as
                  defined for purposes of Rule 436(g) under the Exchange
                  Act); (vii) the suspension of trading of the Company's
                  common stock by the Nasdaq Stock Market, the Commission, or
                  any other governmental authority, or (viii) the taking of
                  any action by any governmental body or agency in respect of
                  its monetary or fiscal affairs which in your reasonable
                  opinion has a material adverse effect on the securities
                  markets in the United States; or

         (b)      as provided in Sections 6 and 9 of this Agreement.

(12)     SUCCESSORS.

         This Agreement has been and is made solely for the benefit of the
Underwriters and the Company and their respective successors, executors,
administrators, heirs and assigns, and the officers, directors and controlling
persons referred to herein, and no other person will have any right or
obligation hereunder. No purchaser of any of the Shares from any Underwriter
shall be deemed a successor or assign merely because of such purchase.

(13)     INFORMATION PROVIDED BY UNDERWRITERS.

         The Company and the Underwriters acknowledge and agree that the only
information furnished or to be furnished by any Underwriter to the Company for
inclusion in any Prospectus or the Registration Statement consists of the
information set forth in legends required by Item 502(d) of Regulation S-K under
the Act and the information in the table after the first paragraph, the third
paragraph (insofar as it relates to concessions and allowances) and the tenth
paragraph under the caption "Underwriting" in the Prospectus.

(14)     MISCELLANEOUS.

         The reimbursement, indemnification and contribution agreements
contained in this Agreement and the representations, warranties and covenants in
this Agreement shall remain in full force and effect regardless of (a) any
termination of this Agreement, (b) any investigation made by or on behalf of any
Underwriter or controlling person thereof, or by or on behalf of the Company or
its directors or officers, and (c) delivery of and payment for the Shares under
this Agreement.


                                       30
<PAGE>

         This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

         This Agreement shall be governed by, and construed in accordance with,
the laws of the State of Maryland.


                                       31

<PAGE>

         If the foregoing letter is in accordance with your understanding of our
agreement, please sign and return to us the enclosed duplicates hereof,
whereupon it will become a binding agreement among the Company and the several
Underwriters in accordance with its terms.

                                         Very truly yours,

                                         GENAISSANCE PHARMACEUTICALS, INC.

                                         By:
                                            --------------------------------
                                         Name:
                                         Title:

The foregoing Underwriting Agreement
is hereby confirmed and accepted as
of the date first above written.

DEUTSCHE BANK SECURITIES INC.
BEAR, STEARNS & CO. INC.
SALOMON SMITH BARNEY, INC.
UBS WARBURG LLC

As Representatives of the several
Underwriters listed on Schedule I

By:  DEUTSCHE BANK SECURITIES INC.

By:
    -------------------------------
     Authorized Officer


                                       32
<PAGE>

                                   SCHEDULE I

                            SCHEDULE OF UNDERWRITERS
<TABLE>
<CAPTION>
                                                                       Number of Firm Shares
         Underwriter                                                        to be Purchased
         -----------                                                   ---------------------
<S>                                                                    <C>
Deutsche Bank Securities, Inc.
Bear, Stearns & Co. Inc.
Salomon Smith Barney, Inc.
UBS Warburg LLC

             TOTAL
</TABLE>


                                       33
<PAGE>

                                    EXHIBIT A

                             LIST OF COMPANY PATENTS












                                       34
<PAGE>

                                    EXHIBIT B

                            FORM OF LEGAL OPINION OF
                             OUTSIDE PATENT COUNSEL












                                       35
<PAGE>

                                    EXHIBIT C

                            FORM OF LEGAL OPINION OF
                        DIRECTOR OF INTELLECTUAL PROPERTY












                                       36



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