TRINITY MEDICAL GROUP INC
SB-2, EX-10.4, 2000-10-20
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT dated as of August 3, 2000, is entered into
between Trinity Medical Group Co. Ltd., a Thai limited company (the "Assignor"),
and Trinity  Medical Group USA, Inc., a Florida  corporation  (the  "Assignee"),
with respect to the following facts:

         WHEREAS, the Assignor and The Immune Response  Corporation,  a Delaware
corporation ("IRC"),  entered into the License and Collaboration Agreement dated
as of  September  15, 1995 (the  "License  Agreement"),  and the Stock  Purchase
Agreement dated as of September 15, 1995 (the "Stock Purchase Agreement").

         WHEREAS,  the  Assignor  desires to assign all of its right,  title and
interest   in  the  License   Agreement   and  the  Stock   Purchase   Agreement
(collectively,  the  "Agreements")  in connection  with the assignment  from the
Assignor to the Assignee of all of the business of the Assignor  relating to the
Product (as defined in the License Agreement).

         NOW THEREFORE, the parties hereby agree as follows:

         1. The Assignor hereby assigns to the Assignee, and the Assignee hereby
assumes,  all of its rights and  obligations  under the Agreements in connection
with the assignment  from the Assignor to the Assignee of all of the business of
the Assignor relating to the Product.

         2. The Assignee  hereby agrees to be bound by the terms and  conditions
of the  Agreements  to the  same  extent  as if the  Assignee  were an  original
signatory to the Agreements.

         IN WITNESS  WHEREOF,  the parties have caused this Agreement to be duly
executed and delivered effective as of the date first set forth above.

TRINITY MEDICAL GROUP CO., LTD.

By:/s/ Inthanom Churdboonchart            By:/s/ Orranart  Churdboonchart
   ---------------------------------         -----------------------------------

Title: Director                           Title: Director
     -------------------------------             -------------------------------


TRINITY MEDICAL GROUP USA, INC

By:/s/ James S. Namnath                   By: /s/ Vina  Churdboonchart
   ---------------------------------         -----------------------------------

Title: Chief Executive Officer            Title: President
     -------------------------------             -------------------------------


<PAGE>


         IRC hereby consents to the assignment from the Assignor to the Assignee
of all of its  Rights  and  obligations  under the  Agreements  on the terms and
conditions of this Agreement.

                                              THE IMMUNE RESPONSE CORPORATION



                                              By: /s/ Dennis J. Carlo, Ph.D.
                                                 -------------------------------

                                              Title: President and CEO
                                                    ----------------------------


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