ILLUMINA INC
S-1/A, EX-5.1, 2000-07-03
LABORATORY ANALYTICAL INSTRUMENTS
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                                                                     Exhibit 5.1
                                                                     -----------

                                 June 30, 2000
Illumina, Inc.
9390 Towne Centre Drive, Suite 200
San Diego, CA 92121

     Re: Registration on Form S-1

Ladies and Gentlemen:

     We have examined the Registration Statement on Form S-1 filed by you with
the Securities and Exchange Commission on April 3, 2000 (Registration No. 333-
33922), as amended (the "Registration Statement"), in connection with the
registration under the Securities Act of 1933, as amended, of up to 5,000,000
shares of your Common Stock, $0.01 par value per share (the "Shares").  The
Shares include an over-allotment option granted to the underwriters of the
offering to purchase up to 750,000 shares.  We understand that the Shares are to
be sold to the underwriters of the offering for resale to the public as
described in the Registration Statement.  As your legal counsel, we have
examined the proceedings taken, and are familiar with the proceedings proposed
to be taken, by you in connection with the sale and issuance of the Shares to be
sold by you.  It is our opinion that upon completion of the proceedings being
taken or contemplated by us, as your counsel, to be taken prior to the issuance
of the Shares, including the proceedings being taken in order to permit such
transaction to be carried out in accordance with applicable state securities
laws, the Shares, when issued and sold in the manner described in the
Registration Statement, will be legally issued, fully paid and non-assessable.
We are members of the Bar of the State of California only and express no opinion
as to any matter relating to the laws of any jurisdiction other than the laws of
the State of California and the federal laws of the United States.  Without
limiting the foregoing, we express no opinion as to the securities laws of the
State of Delaware.  We consent to the use of this opinion as an exhibit to the
Registration Statement and further consent to the use of our name wherever
appearing in the Registration Statement, including the Prospectus constituting a
part thereof, and any amendments thereto.


                                  Very truly yours,

                                  /s/ Wilson Sonsini Goodrich & Rosati

                                  Wilson Sonsini Goodrich & Rosati


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