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<TABLE> <S> <C>
<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM ILLUMINA
INC.'S BALANCE SHEETS AS OF DECEMBER 31, 1999 AND JUNE 30, 2000 AND RELATED
STATEMENTS OF OPERATIONS AND CASH FLOWS FOR THE THREE MONTHS ENDED JUNE 30, 1999
AND 2000 AND FOR THE SIX MONTHS ENDED JUNE 30, 1999 AND 2000 AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<S> <C> <C>
<PERIOD-TYPE> 3-MOS 3-MOS
<FISCAL-YEAR-END> DEC-31-1999 DEC-31-2000
<PERIOD-START> JAN-01-1999 JAN-01-2000
<PERIOD-END> JUN-30-1999 JUN-30-2000
<CASH> 21,164,114 19,595,187
<SECURITIES> 11,924,163 11,544,891
<RECEIVABLES> 49,818 38,287
<ALLOWANCES> 0 0
<INVENTORY> 0 0
<CURRENT-ASSETS> 33,493,045 32,072,232
<PP&E> 296,286 1,621,839
<DEPRECIATION> (4,972) (131,055)
<TOTAL-ASSETS> 33,894,658 33,694,192
<CURRENT-LIABILITIES> 612,408 1,415,555
<BONDS> 0 0
0 0
37,397,998 37,397,998
<COMMON> 51,391 64,213
<OTHER-SE> (5,417,139) (9,954,819)
<TOTAL-LIABILITY-AND-EQUITY> 33,894,658 33,694,192
<SALES> 0 0
<TOTAL-REVENUES> 129,863 78,652
<CGS> 0 0
<TOTAL-COSTS> 1,335,533 5,837,908
<OTHER-EXPENSES> 0 0
<LOSS-PROVISION> 0 0
<INTEREST-EXPENSE> 0 0
<INCOME-PRETAX> 0 0
<INCOME-TAX> 88,195 489,713
<INCOME-CONTINUING> (1,117,475) (5,269,543)
<DISCONTINUED> 0 0
<EXTRAORDINARY> 0 0
<CHANGES> 0 0
<NET-INCOME> (1,117,475) (5,269,543)
<EPS-BASIC> (0.95) (2.05)
<EPS-DILUTED> (0.95) (2.05)
</TABLE>
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