APPLIED MOLECULAR EVOLUTION INC
8-A12G, 2000-07-20
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-A


                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                     PURSUANT TO SECTION 12(b) OR (g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


                        APPLIED MOLECULAR EVOLUTION, INC.
                     (Exact name of registrant as specified
                                 in its charter)


             Delaware                                     33-0374014
     (State of incorporation                          (I.R.S. Employer
         or organization)                            Identification No.)

                3520 Dunhill Street, San Diego, California 92121
               (Address of principal executive offices) (Zip Code)



        Securities to be registered pursuant to Section 12(b) of the Act:



        Title of each class                  Name of each exchange on which
        to be so registered                  each class is to be registered
        -------------------                  ------------------------------
               None                                       None

If this Form relates to the registration of a class of securities pursuant to
Section 12(b) of the Exchange Act and is effective pursuant to General
Instruction A.(c), check the following box.  [ ]

If this Form relates to the registration of a class of securities pursuant to
Section 12(g) of the Exchange Act and is effective pursuant to General
Instruction A.(d), check the following box.  [X]

Securities Act registration statement file number to which this form relates:
333-36830

Securities to be registered pursuant to Section 12(g) of the Act:



                     Common Stock, $.001 par value per share



                                       1
<PAGE>   2

                                (Title of class)

Item 1. Description of Registrant's Securities to be Registered.

In response to this item, incorporated by reference is the description of the
Common Stock, $.001 par value per share (the "Common Stock"), of Applied
Molecular Evolution, Inc. (the "Registrant") contained under the caption
"Description of Capital Stock" in the Prospectus (Subject to Completion) dated
May 12, 2000 that forms a part of the Registrant's Registration Statement on
Form S-1 (File No. 333-36830) (the "Registration Statement"). If such
description is subsequently amended, the description as subsequently amended is
hereby incorporated by reference to this item.

Item 2. Exhibits.

The following exhibits are filed as a part of this Registration Statement:

   1(a)*       Restated Certificate of Incorporation of the Registrant, as
               amended, as filed with the Secretary of State of the State of
               Delaware on April 28, 2000 (incorporated herein by reference to
               Exhibit 3.(i).1 of the Registration Statement).

   1(b)*       Certificate of Amendment of Amended and Restated Certificate of
               Incorporation as filed with the Delaware Secretary of State on
               July 5, 2000 (incorporated herein by reference to Exhibit
               3.(i).1.1 of the Registration Statement).

   1(c)*       Form of Restated Certificate of Incorporation of the Registrant,
               to be filed upon the closing of the offering (incorporated herein
               by reference to Exhibit 3.(i).2 of the Registration Statement).

   2(a)*       Bylaws of the Registrant (incorporated herein by reference to
               Exhibit 3.(ii).1 of the Registration Statement).

   2(b)*       Form of Amended and Restated Bylaws of the Registrant, to be
               effective upon the closing of the offering (incorporated herein
               by reference to Exhibit 3.(ii).2 of the Registration Statement).

   3*          Form of Common Stock Certificate of Registrant (incorporated
               herein by reference to Exhibit 4.1 of the Registration
               Statement).

   4           The description of the Common Stock of the Registrant contained
               under the caption "Description of Capital Stock" set forth on
               page 40 of the Prospectus (Subject to Completion) dated May 12,
               2000 is incorporated herein by reference from the Registration
               Statement. If such description is subsequently amended, the
               description as subsequently amended is hereby incorporated by
               reference to this item.

--------
*   Filed as an exhibit to the Registration Statement or subsequent amendments
    thereto.



                                       2
<PAGE>   3

                                    SIGNATURE

        Pursuant to the requirements of Section 12 of the Securities Exchange
Act of 1934, the Registrant has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereto duly authorized.

        Dated: July 19, 2000


                                       APPLIED MOLECULAR EVOLUTION, INC.

                                       By /s/ Lawrence E. Bloch, M.D., J.D.
                                          ------------------------------------
                                            Lawrence E. Bloch, M.D., J.D.
                                        Chief Financial Officer, Vice President
                                         of Business Development and Secretary



                                       3
<PAGE>   4

                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>
  Exhibit
   Number      Exhibit
   ------      -------
<S>            <C>
   1(a)*       Restated Certificate of Incorporation of the Registrant, as filed
               with the Secretary of State of the State of Delaware on April 28,
               2000 (incorporated herein by reference to Exhibit 3.(i).1 of the
               Registration Statement).

   1(b)*       Certificate of Amendment of Amended and Restated Certificate of
               Incorporation as filed with the Delaware Secretary of State on
               July 5, 2000 (incorporated herein by reference to Exhibit
               3.(i).1.1 of the Registration Statement).

   1(c)*       Form of Restated Certificate of Incorporation of the Registrant,
               to be filed upon the closing of the offering (incorporated herein
               by reference to Exhibit 3.(i).2 of the Registration Statement).

   2(a)*       Bylaws of the Registrant (incorporated herein by reference to
               Exhibit 3.(ii).1 of the Registration Statement).

   2(b)*       Form of Amended and Restated Bylaws of the Registrant, to be
               effective upon the closing of the offering (incorporated herein
               by reference to Exhibit 3.(ii).2 of the Registration Statement).

   3*          Form of Common Stock Certificate of Registrant (incorporated
               herein by reference to Exhibit 4.1 of the Registration
               Statement).

   4           The description of the Common Stock of the Registrant contained
               under the caption "Description of Capital Stock" set forth on
               page 40 of the Prospectus (Subject to Completion) dated May 12,
               2000 is incorporated herein by reference from the Registration
               Statement. If such description is subsequently amended, the
               description as subsequently amended is hereby incorporated by
               reference to this item.
</TABLE>


--------------------

*   Filed as an exhibit to the Registration Statement or subsequent amendments
    thereto.


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