ORBITEX LIFE SCIENCE & BIOTECHNOLOGY FUND INC
N-2/A, 2000-09-29
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  (As filed with the Securities and Exchange Commission on September 29, 2000)
                                               Securities Act File No. 333-34586
                                       Investment Company Act File No. 811-09889
================================================================================


                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                    FORM N-2
             Registration Statement Under The Securities Act of 1933        |X|
                          Pre-Effective Amendment No. 2                     |X|
                         Post-Effective Amendment No. __                    |_|
                                     and/or
        Registration Statement Under The Investment Company Act of 1940     |X|
                                 Amendment No. 2                            |X|
                        (check appropriate box or boxes)



                      ORBITEX LIFE SCIENCES & BIOTECHNOLOGY
                                   FUND, INC.
               (Exact Name of Registrant as Specified in Charter)
                          c/o Orbitex Management, Inc.
                           410 Park Avenue, 18th Floor
                            New York, New York 10022
                    (Address of Principal Executive Offices)
       Registrant's Telephone Number, including Area Code: (212) 891-7900

                                  M. Fyzul Khan
                            Orbitex Management, Inc.
                           410 Park Avenue, 18th Floor
                            New York, New York 10022
                     (Name and Address of Agent for Service)
                                 With a copy to:

                          Leonard B. Mackey, Jr., Esq.
                       Clifford Chance Rogers & Wells LLP
                                 200 Park Avenue
                            New York, New York 10166

                  Approximate Date of Proposed Public Offering:
 As soon as practicable after the effective date of this Registration Statement.

     If any  securities  being  registered  on this  form will be  offered  on a
delayed or continuous  basis in reliance on Rule 415 under the Securities Act of
1933, other than securities  offered in connection with a dividend  reinvestment
plan, check the following box. |X|

     If appropriate, check the following box:

     |_|  This [post-effective]  amendment designates a new effective date for a
          previously filed [post-effective amendment] [registration statement].

     |_|  This form is filed to register  additional  securities for an offering
          pursuant to Rule 462(b) under the  Securities  Act and the  Securities
          Act   registration   statement   number  of  the   earlier   effective
          registration statement or the same offering is _________.


        CALCULATION OF REGISTRATION FEE UNDER THE SECURITIES ACT OF 1933
================================================================================
Title of Securities       Proposed Maximum Aggregate
Being Registered                Offering Price        Amount Of Registration Fee
--------------------------------------------------------------------------------
Common Stock
$.01 Par Value................   $100,000,000                 $26,400*
--------------------------------------------------------------------------------


* Previously paid.

     The Registrant  hereby amends this  Registration  Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further  amendment  which  specifically  states  that  this  Registration
Statement shall  thereafter  become effective in accordance with Section 8(a) of
the Securities  Act of 1933 or until this  Registration  Statement  shall become
effective  on such  date  as the  Securities  and  Exchange  Commission,  acting
pursuant to said Section 8(a), may determine.
================================================================================

<PAGE>


                              CROSS-REFERENCE SHEET

                         Parts A and B of the Prospectus
<TABLE>
<CAPTION>
         Caption                                         Location in Prospectus

<S>      <C>                                             <C>
1.       Outside Front Cover............................ Outside Front Cover Page
2.       Inside Front and Outside Back Cover Page....... Inside Front and Outside Back Cover Page
3.       Fee Table and Synopsis......................... Summary of Fund Expenses
4.       Financial Highlights........................... Not Applicable
5.       Plan of Distribution........................... Outside Front Cover Page; Investment Objective and
                                                         Principal Strategies
6.       Selling Stockholders........................... Not Applicable
7.       Use of Proceeds................................ Use of Proceeds
8.       General Description of the Registrant.......... Outside Front Cover Page; Investment Objective and
                                                         Principal Strategies; Risk Factors; General Information
9.       Management..................................... Management of the Fund; Use of Proceeds
10.      Capital Stock, Long-Term Debt, and Other
         Securities..................................... Capital Stock; Distribution Policy; Taxes
11.      Defaults and Arrears on Senior Securities...... Not Applicable
12.      Legal Proceedings.............................. Not Applicable
13.      Table of Contents of the Statement of
         Additional Information......................... Table of Contents of Statement of Additional Information
14.      Cover Page of SAI.............................. Cover Page (SAI)
15.      Table of Contents of SAI....................... Table of Contents (SAI)
16.      General Information and History................ Appendix A (SAI)
17.      Investment Objective and Policies.............. Additional Investment Policies (SAI)
18.      Management..................................... Directors and Officers (SAI); Investment Advisory and
                                                         Other Services (SAI)
19.      Control Persons and Principal Holders of
         Securities..................................... Not Applicable
20.      Investment Advisory and Other Services......... Investment Advisory and Other Services (SAI)
21.      Brokerage Allocation and Other Practices....... Brokerage Commissions (SAI)
22.      Tax Status..................................... Not Applicable
23.      Financial Statements........................... Financial Statements (SAI)
</TABLE>

<PAGE>


PROSPECTUS

                Orbitex Life Sciences & Biotechnology Fund, Inc.


                        4,000,000 Shares of Common Stock

                                  $25 Per Share


     Investment  Objective.  The  Fund  is a newly  organized,  non-diversified,
closed-end  management investment company. The Fund's investment objective is to
seek long-term growth of capital through selective  investment in the securities
of life sciences and  biotechnology  companies of all sizes that offer potential
for growth.


     Investment Strategies.  The Fund will invest primarily in the securities of
companies primarily engaged in life sciences, pharmaceuticals,  medical research
and  biotechnology  research,  development and  implementation,  and other areas
related  to  the  life  sciences  and  biotechnology  industries.  Under  normal
circumstances,  the Fund will invest at least 65% of its total  assets in equity
securities issued by life sciences companies and biotechnology  companies.  As a
matter of fundamental  policy, the Fund will concentrate (invest at least 25% of
its total  assets) in  securities  issued by companies in the life  sciences and
biotechnology industries.  The Fund will invest primarily in U.S. common stocks,
but also may invest in other types of equity securities and debt securities. The
Fund may invest up to 35% of its total  assets in debt  securities  rated  below
investment grade or unrated  securities of equivalent quality (commonly referred
to as "junk bonds"). The Fund may invest in companies of any size, but generally
expects to invest a majority of its assets in small and medium-sized  companies.
The  Fund may  invest a  significant  portion  of its  total  assets  in  equity
securities of privately  owned life sciences and  biotechnology  companies  that
plan to conduct an initial  public  offering  or IPO.  These are  referred to as
venture  capital  companies.  There will be no public market for the shares of a
venture capital company at the time of the Fund's  investment,  and there can be
no assurance that a planned IPO will ever be completed.

     Manager.  The  Fund's  investment  manager  is  Orbitex  Management,   Inc.
("Orbitex").


     Lack of  Trading  Market.  The  Fund's  shares  will not be  listed  on any
securities  exchange,  and there is no assurance that any secondary  market will
develop for the Fund's shares.  You may not be able to sell your shares.  Shares
may be held only through brokers and dealers that have entered into  shareholder
servicing agreements with the Fund.

     Investing in the Fund's  shares  involves a high degree of risk.  See "Risk
Factors" beginning on page 7.

     Neither the  Securities and Exchange  Commission  nor any state  securities
commission  has approved or disapproved  these  securities or determined if this
prospectus  is truthful or  complete.  Any  representation  to the contrary is a
criminal offense.

                                                   Per Share            Total
                                                   ---------            -----
Offering Price .........................           $   26.00        $104,000,000
Sales Load .............................           $    1.00        $  4,000,000
Proceeds to Fund .......................           $   25.00        $100,000,000


     This  prospectus  concisely  provides the  information  that a  prospective
investor  should know about the Fund before  investing.  You are advised to read
this  prospectus  carefully  and to retain it for future  reference.  Additional
information  about the Fund,  including a statement  of  additional  information
("SAI") dated October 2, 2000,  has been filed with the  Securities and Exchange
Commission.  The SAI is  available  upon  request and without  charge by calling
1-877-246-8282. The SAI is incorporated by reference into this prospectus in its
entirety.  The SAI and other information about the Fund also is available on the
SEC's website (http://www.sec.gov).

                                 OCTOBER 2, 2000



                                       ii
<PAGE>



     The Fund is offering up to  4,000,000  shares of its common  stock  through
Orbitex Funds  Distributor,  Inc., the Fund's  distributor.  The distributor has
entered into selected dealer agreements with various dealers that have agreed to
use their best efforts to sell the Fund's shares. The dealers have no obligation
to sell any  specific  number of Fund  shares.  The Fund will pay Orbitex  Funds
Distributor,  Inc., an affiliate of Orbitex,  a one-time  placement fee equal to
0.50% of the net  proceeds  to the Fund.  The Fund will pay each dealer that has
entered  into  a  shareholder   servicing   agreement  with  the  distributor  a
shareholder  servicing fee at the annual rate of 0.25% of the net asset value of
the outstanding shares  beneficially  owned by customers of the dealer.  Orbitex
will make  additional  annual  payments of 0.25% of such net asset value to each
such  dealer  from its own  resources.  The  Fund  will  pay  offering  expenses
estimated at $95,775 from the proceeds of the offering.





     Repurchase  Offers.  In order to provide a limited  degree of  liquidity to
shareholders,  the Fund  will make  quarterly  offers  to  repurchase  5% of its
outstanding shares at their net asset value. Tendering shareholders may not have
all of their tendered  shares  repurchased by the Fund. The Fund intends to make
its first quarterly repurchase offer in March 2001. See "Repurchase Offers."


     Management  Fee.  The Fund will pay Orbitex a  management  fee at an annual
rate of 1.75% of the Fund's  average daily net assets.  The overall fees payable
by the Fund and its  shareholders  will be higher  than those paid by most other
funds.

     Minimum Investment. The minimum investment in the Fund is $25,000.



     Shares of the Fund are not deposits or  obligations  of, or  guaranteed  or
endorsed  by,  any bank or other  insured  depository  institution,  and are not
federally  insured by the Federal  Deposit  Insurance  Corporation,  the Federal
Reserve Board or any other government agency.

     You should rely only on the information  contained in this prospectus.  The
Fund has not authorized  anyone to provide you with different  information.  The
Fund is not making an offer of these  securities in any state where the offer is
not  permitted.  You should not assume  that the  information  provided  by this
prospectus  is  accurate as of any date other than the date on the front of this
prospectus.


                                      iii
<PAGE>


                                TABLE OF CONTENTS

                                                                            Page



PROSPECTUS SUMMARY............................................................1

SUMMARY OF FUND EXPENSES......................................................6

RISK FACTORS..................................................................7

USE OF PROCEEDS..............................................................12

MANAGEMENT OF THE FUND.......................................................17

REPURCHASE OFFERS............................................................18

CALCULATION OF NET ASSET VALUE...............................................20

CAPITAL STOCK................................................................21

DISTRIBUTION POLICY..........................................................21

TAXES  2

DISTRIBUTION.................................................................23

GENERAL INFORMATION..........................................................24

TABLE OF CONTENTS OF SAI.....................................................25


                                       iv
<PAGE>


                               PROSPECTUS SUMMARY

This is only a summary. This summary may not contain all of the information that
you should  consider  before  investing in the Fund.  You should review the more
detailed  information  contained  in this  prospectus  and in the  statement  of
additional information.

The Fund                           Orbitex Life Sciences &  Biotechnology  Fund,
                                   Inc.  (the  "Fund")  is  a  newly  organized,
                                   non-diversified,     closed-end    management
                                   investment   company   registered  under  the
                                   Investment  Company  Act of 1940,  as amended
                                   (the  "Investment  Company Act").  The Fund's
                                   investment  manager  is  Orbitex  Management,
                                   Inc. ("Orbitex"). See "General Information."

Investment Objective and           The objective of the Fund is long-term growth
Principal Strategies               of capital  through  selective  investment in
                                   the   securities   of   life   sciences   and
                                   biotechnology  companies  of all  sizes  that
                                   offer potential for growth.


                                   The  Fund  will  invest   primarily   in  the
                                   securities  of   companies,   both  U.S.  and
                                   foreign,  primarily engaged in life sciences,
                                   pharmaceuticals,    medical    research   and
                                   biotechnology   research,   development   and
                                   implementation,  and other  areas  related to
                                   the   life    sciences   and    biotechnology
                                   industries.  Under normal circumstances,  the
                                   Fund  will  invest  at least 65% of its total
                                   assets  in equity  securities  issued by life
                                   sciences and  biotechnology  companies.  As a
                                   matter of fundamental  policy,  the Fund will
                                   concentrate (invest at least 25% of its total
                                   assets) in securities  issued by companies in
                                   the   life    sciences   and    biotechnology
                                   industries. The Fund will invest primarily in
                                   U.S.  common  stocks,  but also may invest in
                                   other  types of  equity  securities  and debt
                                   securities.  The Fund may invest up to 35% of
                                   its  total  assets in debt  securities  rated
                                   below investment grade or unrated  securities
                                   of equivalent  quality (commonly  referred to
                                   as "junk  bonds").  The Fund  may  invest  in
                                   companies of any size, but generally  expects
                                   to invest a  majority  of its assets in small
                                   and  medium-sized  companies.  The  Fund  may
                                   invest a  significant  portion  of its  total
                                   assets  in  equity  securities  of  privately
                                   owned   life   sciences   and   biotechnology
                                   companies  that plan to  conduct  an  initial
                                   public offering or IPO. These are referred to
                                   as venture capital  companies.  There will be
                                   no public  market for the shares of a venture
                                   capital  company  at the  time of the  Fund's
                                   investment,  and  there  can be no  assurance
                                   that a planned  IPO will  ever be  completed.
                                   The Fund also may invest in  private  venture
                                   capital funds that specialize in investing in
                                   life  sciences and  biotechnology  companies.
                                   See   "Investment   Objective  and  Principal
                                   Strategies."

                                   The   Fund   may   use   various   investment
                                   techniques   to  hedge  a   portion   of  its
                                   investment portfolio against certain risks or
                                   to pursue its investment  objective.  In this
                                   regard,  the  Fund  may  use  leverage,  sell
                                   securities  short,  purchase and sell options
                                   on  securities  and stock  indexes  and other
                                   derivatives,  and enter into foreign currency
                                   transactions,  subject to certain limitations
                                   described  elsewhere in this Prospectus.  The
                                   use of some of  these  investment  techniques
                                   and  instruments  will be an integral part of
                                   the Fund's investment programs,  and involves
                                   certain risks. See "Risk Factors."


The Manager                        Orbitex is the Fund's investment  manager. As
                                   of   August 31,    2000,    Orbitex   managed
                                   approximately  $1.024  billion  in  11 mutual
                                   fund portfolios  and  for  institutional  and
                                   other accounts.



                                       1
<PAGE>


                                   Timothy  F.  Bepler,  CFA  is  the  portfolio
                                   manager  for  the  Fund.  Mr.  Bepler  joined
                                   Orbitex  in  1999  as a  Vice  President  and
                                   portfolio manager.  He brought with him eight
                                   years of  investment  analysis  experience in
                                   the healthcare industry.  Formerly,  he was a
                                   Vice   President   at  Merrill   Lynch  Asset
                                   Management  from 1996 to 1999  where he was a
                                   healthcare  analyst  for a Growth  and Income
                                   fund.  Prior to joining Merrill Lynch, he was
                                   the sole healthcare analyst for a division of
                                   Credit  Suisse  from  1995 to 1996  and was a
                                   senior  analyst  at  Value  Line,  Inc.  from
                                   1989-1995. See "Management of the Fund."

Investment Adviser Fees            The Fund will pay to Orbitex a management fee
                                   at an  annual  rate of  1.75%  of the  Fund's
                                   average daily net assets.  The management fee
                                   is higher than the advisory fees paid by most
                                   U.S. investment companies.

Borrowing                          The Fund is  authorized  to  borrow  money to
                                   fund the  purchase  of  portfolio  securities
                                   (including additional  investments in venture
                                   capital companies in its portfolio),  to meet
                                   repurchase  requests and for cash  management
                                   purposes. The use of borrowings for financial
                                   leverage  involves a high degree of risk. The
                                   Fund  generally  intends to borrow money only
                                   in  limited   circumstances  when  attractive
                                   investment  opportunities  are available that
                                   would further the Fund's investment objective
                                   and sufficient cash or other liquid resources
                                   are not otherwise available, or where Orbitex
                                   believes  it  would  not be  prudent  to sell
                                   existing  portfolio  holdings.  The Fund will
                                   not,  in any event,  borrow  money  until the
                                   proceeds of the  offering  are  substantially
                                   invested   in   furtherance   of  the  Fund's
                                   investment   objective.   The   Fund  is  not
                                   permitted   to  borrow  to  make   additional
                                   investments  at  any  time  that   borrowings
                                   exceed 20% of its total assets, and it is not
                                   permitted  to  borrow  for  any  purpose  if,
                                   immediately  after such  borrowing,  it would
                                   have an asset  coverage  (as  defined  in the
                                   Investment  Company  Act) of less than  300%.
                                   The Fund will seek to repay  borrowings  used
                                   to meet  repurchase  requests  and  for  cash
                                   management  purposes within one year of their
                                   incurrence.   See  "Risk   Factors--Leverage;
                                   Borrowing"  and  "Investment   Objective  and
                                   Principal  Strategies  -  Borrowing;  Use  of
                                   Leverage."

Hedging                            The Fund may use  derivative  instruments  to
                                   hedge portfolio risks and for cash management
                                   purposes.  Hedging  activity  may relate to a
                                   specific  security or to the Fund's portfolio
                                   as a whole.  The Fund may not use  derivative
                                   instruments to seek increased  returns on its
                                   investments.

Investor Suitability               An   investment   in  the  Fund   involves  a
                                   considerable  amount of risk.  Because  it is
                                   possible  that  you may  lose  some or all of
                                   your investment, you should not invest in the
                                   Fund  unless  you can  afford a total loss of
                                   your   investment.   Prior  to  making   your
                                   investment decision,  you should (i) consider
                                   the   suitability  of  this  investment  with
                                   respect  to your  investment  objectives  and
                                   personal  situation,  (ii)  consider  factors
                                   such as your personal net worth, income, age,
                                   risk tolerance and liquidity needs, and (iii)
                                   consult your broker and financial  adviser to
                                   determine   whether   your  risk  profile  is
                                   suitable for this investment.


The Offering                       The Fund is offering up to  4,000,000  shares
                                   of common stock at $25 per share plus a sales
                                   charge through its co-distributors, Funds



                                       2
<PAGE>




                                   Distributor,    Inc.   and   Orbitex    Funds
                                   Distributor, Inc. Funds Distributor, Inc. has
                                   entered into selected dealer  agreements with
                                   various dealers that have agreed to use their
                                   best efforts to sell the Fund's  shares.  The
                                   dealers  are  not   obligated   to  sell  any
                                   specific   number  of  Fund  shares.   It  is
                                   contemplated  that the dealers  will  solicit
                                   subscriptions   for  Fund  shares   during  a
                                   subscription  period  which  shall  end on or
                                   about November 3, 2000 (the  "Closing Date"),
                                   at   which  time  the   Fund  will   commence
                                   operations. The Fund, in its sole discretion,
                                   may accelerate the Closing Date or may extend
                                   it.  During the 90-day  period  following the
                                   Closing  Date or such other period of time as
                                   may be  determined  by the  Fund in its  sole
                                   discretion,  the Fund will continuously offer
                                   its shares to  investors  at its then current
                                   net  asset  value  per  share  plus the sales
                                   charge. The minimum investment in the Fund is
                                   $25,000.  See  "Distribution."  The Fund will
                                   pay Orbitex Funds  Distributor, Inc. ("OFD"),
                                   an affiliate of Orbitex, a one-time placement
                                   fee equal to  0.50% of the  value of  the net
                                   proceeds  to  the   Fund  raised  during  the
                                   subscription   period  and   the   continuous
                                   offering  period.  Orbitex   will  pay  Funds
                                   Distributor, Inc.  from its own  resources an
                                   annual fee of $40,000 in  consideration   for
                                   acting  as co-distributor.  The Fund will pay
                                   each  dealer  that   has   entered   into   a
                                   shareholder  servicing  agreement   with  the
                                   distributor a  shareholder  servicing  fee at
                                   the  annual rate of  0.25% of  the net  asset
                                   value of the outstanding shares  beneficially
                                   owned  by customers  of  the dealer.  Orbitex
                                   will make additional annual payments of 0.25%
                                   of such net asset value to  each such  dealer
                                   from its own resources.


Distribution Policy                The Fund  will pay  dividends  on the  shares
                                   annually     in     amounts      representing
                                   substantially   all  of  the  net  investment
                                   income,  if  any,  earned  each  year.  It is
                                   likely  that many of the  companies  in which
                                   the Fund invests will not pay any  dividends,
                                   and this,  together with the Fund's expenses,
                                   means that the Fund is  unlikely  to have net
                                   investment income to pay dividends.

                                   The Fund  will pay  substantially  all of any
                                   taxable   net   capital   gain   realized  on
                                   investments   to    shareholders   at   least
                                   annually.

                                   Under the Fund's automatic reinvestment plan,
                                   dividends  and/or capital gain  distributions
                                   paid  by  the  Fund  will  be  reinvested  in
                                   additional   shares  of  the  Fund  unless  a
                                   shareholder   "opts  out"   (elects   not  to
                                   participate). Shares will be issued under the
                                   plan  at  their  net   asset   value  on  the
                                   ex-dividend date. There is no sales charge or
                                   other  charge  for  reinvestment.   The  Fund
                                   reserves  the right to  suspend  or limit the
                                   automatic reinvestment plan at any time.

Unlisted Closed-End Structure;     The Fund has been  organized  as a closed-end
Limited Liquidity                  management  investment  company.   Closed-end
                                   funds   differ   from   open-end   management
                                   investment   companies   (commonly  known  as
                                   mutual  funds)  in  that  shareholders  of  a
                                   closed-end  fund do not  have  the  right  to
                                   redeem  their  shares  on a daily  basis.  In
                                   order  to  meet  daily  redemption  requests,
                                   mutual  funds are  subject to more  stringent
                                   regulatory limitations than closed-end funds.
                                   In  particular,  a mutual fund  generally may
                                   not  invest  more  than 15% of its  assets in
                                   illiquid  securities.  The Fund believes that
                                   unique investment  opportunities exist in the
                                   market for venture  capital life sciences and
                                   biotechnology  companies and in private funds
                                   that invest in venture  capital life sciences
                                   and biotechnology  companies.  However, these
                                   venture   capital   investments   are   often
                                   illiquid,  and an open-end  fund's ability to
                                   make  illiquid  investments  is limited.  For
                                   this  reason,  the  Fund  is


                                       3
<PAGE>


                                   organized as a closed-end fund.

                                   The Fund  will not  list  its  shares  on any
                                   securities   exchange,   and   there   is  no
                                   assurance  that  any  secondary  market  will
                                   develop for the Fund's  shares.  You will not
                                   be  able to  redeem  your  shares  on a daily
                                   basis because the Fund is a closed-end  fund.
                                   Shares  may be held only  through a broker or
                                   dealer  that has entered  into a  shareholder
                                   servicing  agreement with the Fund. Shares of
                                   the Fund may not be  exchanged  for shares of
                                   any other fund. As described below,  however,
                                   in order  to  provide  a  limited  degree  of
                                   liquidity,  the Fund will  conduct  quarterly
                                   repurchase  offers for 5% of its  outstanding
                                   shares. An investment in the Fund is suitable
                                   only for  investors  who can  bear the  risks
                                   associated with the limited  liquidity of the
                                   shares  and  should be viewed as a  long-term
                                   investment.

Quarterly Repurchase Offers        In order  to  provide  a  limited  degree  of
                                   liquidity  to  shareholders,  the  Fund  will
                                   conduct quarterly repurchase offers. The Fund
                                   intends  to  commence  the  first  repurchase
                                   offer  in  March  2001.  In  each  repurchase
                                   offer,  the Fund will offer to  repurchase 5%
                                   of its outstanding  shares at their net asset
                                   value.  The Fund may offer to repurchase more
                                   than 5% of its shares in any quarter with the
                                   approval  of the board of  directors.  If the
                                   number  of  shares  tendered  for  repurchase
                                   exceeds  the  number  the  Fund   intends  to
                                   repurchase,  the Fund will repurchase  shares
                                   on   a   pro-rata   basis,    and   tendering
                                   shareholders  will  not  have  all  of  their
                                   tendered shares  repurchased by the Fund. See
                                   "Repurchase    Offers."

Risk Factors                       An  investment  in the Fund  involves  a high
                                   degree of risk. These include the risks of:

                                   o    Investing    in   life    sciences   and
                                        biotechnology    companies    -    These
                                        companies   are  subject  to  government
                                        regulation   and   approval   of   their
                                        products and services,  which can have a
                                        significant   effect  on  their   market
                                        price. The types of products or services
                                        produced or provided by these  companies
                                        may  quickly  become  obsolete.  Many of
                                        these companies are relatively small and
                                        have thinly traded  securities,  may not
                                        yet   offer   products   and  may   have
                                        persistent losses during a new product's
                                        transition    from     development    to
                                        production.

                                   o    Investing in venture  capital  companies
                                        and  private  venture  capital  funds  -
                                        Venture  capital   companies   represent
                                        highly  speculative   investments.   The
                                        Fund's  ability to realize value from an
                                        investment in a venture  capital company
                                        is to a large degree  dependent upon the
                                        successful  completion  of the company's
                                        IPO or the sale of the  venture  capital
                                        company  to another  company,  which may
                                        not occur for a period of several  years
                                        after the date of the Fund's investment,
                                        if ever.

                                   o    Investing   in   securities   that   are
                                        illiquid   and   volatile   -   Illiquid
                                        securities  involve  the risk  that they
                                        cannot  be sold at the time  desired  by
                                        the Fund or at prices  approximating the
                                        value  the  Fund has  determined.  Stock
                                        prices of  biotechnology  companies  are
                                        very volatile and the Fund's performance
                                        may  sometimes  be  significantly  worse
                                        than that of other types of funds.

                                   o    Investing  in  illiquid   shares  of  an
                                        unlisted closed-end fund - The Fund does
                                        not   intend  to  list  its  shares  for
                                        trading  on  any   national


                                       4
<PAGE>


                                        securities  exchange.  The Fund's shares
                                        are  not  readily   marketable  and  are
                                        significantly less liquid than shares of
                                        funds that trade on an exchange. Because
                                        the  Fund  is  a  closed-end  investment
                                        company,  shares  of the Fund may not be
                                        redeemed on a daily basis.  Although the
                                        Fund  will  make  quarterly   repurchase
                                        offers,  you may not be able to sell all
                                        the  shares  that  you wish to sell in a
                                        repurchase offer.

                                   o    Investing  in a  fund  that  may  employ
                                        substantial leverage - To the extent the
                                        Fund uses leverage, the value of its net
                                        assets will tend to increase or decrease
                                        at a greater  rate  than if no  leverage
                                        were employed.

                                   o    Concentration   in  a  small  number  of
                                        industry   sectors  and   maintaining  a
                                        "non-diversified"  portfolio - Since the
                                        Fund's portfolio will be concentrated in
                                        securities   of  a   small   number   of
                                        companies or in  securities of companies
                                        in a small  number  of  industries,  the
                                        risk  of  any  investment   decision  is
                                        increased.

                                   o    Investing  in  small  companies  - Small
                                        companies   may  be   subject   to  poor
                                        corporate   performance   due  to   less
                                        experienced management,  limited product
                                        lines,    undeveloped   markets   and/or
                                        limited financial resources, and to less
                                        predictable   returns   due  to  shorter
                                        operating   histories,   less   publicly
                                        available  information  and little or no
                                        research by the investment community.

                                   o    Investing in debt securities rated below
                                        investment grade - Non-investment  grade
                                        securities    are   considered   to   be
                                        predominantly  speculative  with respect
                                        to the issuer's capacity to pay interest
                                        and repay principal.

                                   o    Investing  in   securities  of  non-U.S.
                                        issuers   -  Foreign   securities   face
                                        specific risks,  including:  unfavorable
                                        changes in currency rates,  restrictions
                                        on the  repatriation of capital invested
                                        abroad,    reduced    availability    of
                                        information,  different  accounting  and
                                        financial    standards,    and   reduced
                                        liquidity  as  a  result  of  inadequate
                                        trading volume.

                                   Accordingly,  the Fund should be considered a
                                   speculative investment, and you should invest
                                   in  the  Fund  only  if  you  can  sustain  a
                                   complete loss of your investment.  For a more
                                   complete  discussion of the risks,  see "Risk
                                   Factors."


                                       5
<PAGE>


                            SUMMARY OF FUND EXPENSES

          The following  table  illustrates  the expenses and fees that the Fund
     expects to incur and that shareholders can expect to bear.

    Shareholder Transaction Expenses:

        Maximum Sales Load (as a percentage of offering price)...........  4.00%
        Automatic Reinvestment Plan Fees.................................   none
        Maximum Redemption Fees..........................................   none

    Annual Expenses (except for interest expense,  as a percentage of net assets
    attributable to common shares):
        Management Fee...................................................  1.75%
        Shareholder Servicing Fees.......................................  0.25%
        Other Expenses...................................................  0.75%
        Total Annual Expenses (other than interest expense)..............  2.75%


     The  purpose  of the table  above is to  assist  you in  understanding  the
various  costs  and  expenses  you  would  bear  directly  or  indirectly  as  a
shareholder of the Fund. The annual "Other  Expenses" shown above are estimated,
based  on net  assets  of the  Fund of $100  million.  The  Fund  will pay OFD a
one-time  placement  fee equal to 0.50% of the net  proceeds  of this  offering,
which is not included in "Total Annual  Expenses"  above. The Fund also will pay
offering expenses,  estimated to be $95,775,  from the proceeds of the offering;
these  expenses are not included in "Total Annual  Expenses"  above.  For a more
complete  description  of the  various  costs  and  expenses  of the  Fund,  see
"Management of the Fund."


Example:
                                             1 year  3 years  5 years   10 years
                                             ------  -------  -------   --------


You would pay the following expenses
on a $1,000 investment,
assuming a 5% annual return ..............     $ 67     $122     $180       $336



     The example does not present actual expenses and should not be considered a
representation  of future expenses.  Actual expenses may be greater or less than
those shown.  Moreover,  the Fund's actual rate of return may be greater or less
than the  hypothetical  5% return  shown in the  example.  The  Fund's  offering
expenses  and  one-time  placement  fee payable to OFD are not  reflected in the
example.



                                       6
<PAGE>


                                  RISK FACTORS

General

     Stock prices fluctuate. Apart from the specific risks identified below, the
Fund's   investments  may  be  negatively   affected  by  the  broad  investment
environment in the U.S. and international  securities  markets.  That investment
environment is influenced  by, among other things,  interest  rates,  inflation,
politics,   fiscal  policy,  current  events,   competition,   productivity  and
technological and regulatory change. Therefore, as with any fund that invests in
stocks,  the  Fund's  net asset  value  will  fluctuate.  You may  experience  a
significant  decline in the value of your  investment and could lose your entire
investment.  The Fund should be  considered a  speculative  investment,  and you
should  invest  in the Fund  only if you can  sustain  a  complete  loss of your
investment.

Risks of Life Sciences and Biotechnology Sectors

     Because of its specific  focus,  the Fund's  performance is closely tied to
and  affected  by  events  occurring  in the  life  sciences  and  biotechnology
industries.  Companies in the same industry often face similar obstacles, issues
and regulatory  burdens. As a result, the securities owned by the Fund may react
similarly to and move in unison with one another.  Life  sciences  companies are
subject to government  regulation  and approval of their  products and services,
which  can  have  a  significant  effect  on  their  market  price.  Changes  in
governmental  policies may have a material  effect on the demand for  particular
products and services. Regulatory approvals (often entailing lengthy application
and testing  procedures)  may be required  before new drugs and certain  medical
devices and procedures can be introduced.  Furthermore, the types of products or
services  produced or provided by these  companies may quickly become  obsolete.
Moreover,  liability for products that are later alleged to be harmful or unsafe
may be  substantial,  and  may  have a  significant  impact  on a life  sciences
company's market value and/or share price.  Biotechnology companies are affected
by patent  considerations,  intense  competition,  rapid  technology  change and
obsolescence, and regulatory requirements of various federal and state agencies.
The enforcement of patent,  trademark and other intellectual  property laws will
affect  the  value  of many of  these  companies.  In  addition,  many of  these
companies are relatively  small and have thinly traded  securities,  may not yet
offer products or offer a single product,  and may have persistent losses during
a new product's  transition  from  development to production or erratic  revenue
patterns.  While the Fund generally will make its investments  based on a belief
that actual or anticipated products or services will produce future earnings, if
an anticipated  event is delayed or does not occur,  or if investor  perceptions
about a company  change,  the company's  stock price may decline sharply and its
securities  may become less  liquid.  Moreover,  stock  prices of  biotechnology
companies  are  very  volatile,  particularly  when  their  products  are up for
regulatory approval and/or under regulatory scrutiny.  Consequently,  the Fund's
performance  may sometimes be  significantly  better or worse than that of other
types of funds.

Newly Organized Fund

     The Fund is a newly organized investment company with no previous operating
history.  Although Orbitex and the Fund's portfolio  managers have  considerable
experience  managing  other  funds  with  investment  objectives  similar to the
Fund's,  the Fund may not succeed in meeting its  objective,  and the Fund's net
asset value may decrease.

Unlisted Closed-End Fund; Limited Liquidity

     The  Fund  is  a  closed-end  investment  company  designed  primarily  for
long-term  investors and is not intended to be a trading vehicle.  The Fund does
not intend to list its shares for trading on any national  securities  exchange.
There is no secondary trading market for Fund shares,  and there is no assurance
that a secondary  market  will  develop.  The Fund's  shares are  therefore  not
readily marketable.  Because the Fund is a closed-end investment company, shares
of the Fund may not be redeemed on a daily basis,  and they may not be exchanged
for shares of any other fund.  Although the Fund, as a fundamental  policy, will
make  quarterly  repurchase  offers for 5% (or more,  at the  discretion  of the
Fund's  board of  directors)  of its  outstanding  shares of common stock at net
asset  value,  the Fund's  shares are  significantly  less liquid than shares of
funds that trade on a stock exchange. Also, because the common stock will not be
listed  on any  securities  exchange,  the  Fund is not  required,  and does not
intend, to hold annual meetings of shareholders.


                                       7
<PAGE>


     You  may not be able to sell  all the  shares  that  you  wish to sell in a
repurchase  offer.  In  extreme  cases,  the  Fund  may not be able to  complete
repurchases due to its holding of illiquid  investments.  In that event, you may
be able to sell your shares only if you are able to find an investor  willing to
purchase your shares.  Any such sale may have to be  negotiated  at  unfavorable
prices.

Leverage; Borrowing

     The Fund is  authorized  to borrow  money to fund the purchase of portfolio
securities,  to meet repurchase requests and for cash management  purposes.  The
Fund  may  not  borrow  for  the  purpose  of  purchasing  additional  portfolio
securities at any time that borrowings exceed 20% of its total assets.  The Fund
will seek to repay  borrowings  used to meet  repurchase  requests  and for cash
management  purposes within one year of their incurrence.  The use of borrowings
for financial leverage involves a high degree of risk.

     To the extent that the Fund uses leverage, the value of its net assets will
tend to  increase  or  decrease  at a  greater  rate  than if no  leverage  were
employed.  If the  Fund's  investments  decline  in  value,  your  loss  will be
magnified if the Fund has borrowed money to make its investments.

     If the Fund does not generate sufficient cash flow from operations,  it may
not be able to repay borrowings within one year of their  incurrence,  or it may
be  forced  to sell  investments  at  disadvantageous  times  in  order to repay
borrowings.  The Fund's  performance may be adversely affected if it is not able
to repay  borrowings  (because of the continuing  interest  expense) or if it is
forced  to  sell  investments  at  disadvantageous   times  in  order  to  repay
borrowings.

     The Investment Company Act provides that the Fund may not declare dividends
or distributions, or purchase its stock (including in repurchase offers) unless,
immediately  after doing so, it will have an "asset  coverage" of at least 300%.
This could prevent the Fund from  completing  its  repurchase  offers.  For this
purpose,  an "asset  coverage"  of 300% means that the Fund's total assets equal
300% of the total  outstanding  principal  balance of indebtedness.  Lenders may
require the Fund to agree to more restrictive  asset coverage  requirements as a
condition  to  providing  credit to the Fund,  and may also  limit the extent to
which the Fund may hold  illiquid  securities,  reducing  the Fund's  investment
flexibility.  If the Fund is unable to make  distributions  as a result of these
requirements,  it may no longer  qualify as a regulated  investment  company and
could be required to pay additional  taxes.  The Fund may also be forced to sell
investments on unfavorable terms if market  fluctuations or other factors reduce
its asset  level below what is  required  by the  Investment  Company Act or the
Fund's loan agreements.

     Successful  use of borrowing for financial  leverage  purposes (that is, to
acquire  portfolio  securities)  will  depend on  Orbitex's  ability  to predict
correctly interest rates and market movements,  and there is no assurance that a
borrowing strategy will be successful during any period in which it is employed.

     The rights of any  lenders to the Fund to receive  payments  of interest or
repayments  of  principal  will be senior to those of the  holders of the Fund's
shares,  and the terms of any  borrowings  may  contain  provisions  that  limit
certain  activities of the Fund,  including the payment of dividends (if any) to
holders  of shares  under  certain  circumstances.  Interest  payments  and fees
incurred in connection  with  borrowings  will increase the Fund's expense ratio
and will reduce any income the Fund  otherwise  has available for the payment of
dividends.  The Fund's  obligation  to make  interest or  principal  payments on
borrowings may prevent the Fund from taking  advantage of attractive  investment
opportunities.

Short Sales

     The  Fund  may  sell  securities  short  as part of its  overall  portfolio
management  strategy  involving the use of derivative  instruments and to offset
potential  declines in long positions in similar  securities.  A short sale is a
transaction in which the Fund sells a security it does not own or have the right
to acquire (or that it owns but does not wish to deliver) in  anticipation  that
the market price of that security will decline.

Repurchase Offers

     The Fund will offer to  purchase  only a small  portion of its shares  each
quarter,  and  there is no  guarantee  that you will be able to sell all of your
Fund shares that you desire to sell in any  particular  repurchase  offer.  If a
repurchase offer is  oversubscribed  by  shareholders,  the Fund will repurchase
only a pro  rata  portion  of the  shares  tendered  by  each  shareholder.  The
potential  for  pro-ration  may cause some  investors  to tender more shares for
repurchase than they wish to have repurchased.


                                       8
<PAGE>


     The Fund's repurchase policy will have the effect of decreasing the size of
the Fund over time from what it  otherwise  would  have been.  It may  therefore
force the Fund to sell assets it would not  otherwise  sell.  It may also reduce
the investment  opportunities  available to the Fund and cause its expense ratio
to increase.  In addition,  because of the limited market for the Fund's venture
capital  investments,  the  Fund  may be  forced  to sell  its  publicly  traded
securities in order to meet cash requirements for repurchases. This may have the
effect of substantially  increasing the Fund's ratio of illiquid venture capital
investments to liquid investments for the remaining investors.

Investments In Small Companies

     The Fund plans to invest  primarily in the stock of small and  medium-sized
companies.  These  investments may present greater  opportunity for growth,  but
there are specific risks associated with  investments in small companies,  which
include:

     o    poor corporate performance due to less experienced management, limited
          product lines, undeveloped markets and/or limited financial resources

     o    less  predictable  returns due to shorter  operating  histories,  less
          publicly  available  information  and  little  or no  research  by the
          investment community

     o    reduced or zero  liquidity  due to small  market  capitalizations  and
          absence of exchange listings or dealers willing to make a market

     o    increased  share price  volatility due to the fact that, in periods of
          investor uncertainty,  investor sentiment may favor large,  well-known
          companies over small, lesser-known companies

     o    reliance, in many cases, on one or two key individuals for management

Investments in Venture Capital Companies

     The Fund may invest a  substantial  portion of its assets in  securities of
venture  capital  companies,  which present all the risks of investment in small
companies  described  above  plus  certain  additional  risks.  Venture  capital
companies  represent  highly  speculative  investments  by the  Fund.  The risks
associated  with investing in companies in the "seed" or  "expansion"  stages of
development are greater than those of companies in the "late" or "pre-IPO" stage
(these terms are explained under "Investment  Objective and Principal Strategies
-  Investment  in Life  Sciences  and  Biotechnology  Companies"),  because  the
concepts  generally are unproven,  the companies have little or no track record,
and the prospect of an initial public offering is highly contingent upon factors
that often are not in the companies' control. For example, since venture capital
companies  do not  file  periodic  reports  with  the  Securities  and  Exchange
Commission,  there is less publicly available  information about them than there
is for other small  companies,  if there is any at all. The Fund must  therefore
rely solely on Orbitex to obtain adequate  information to evaluate the potential
returns  from  investing  in  these  companies.  In  addition,  venture  capital
companies tend to rely even more heavily on the abilities of their key personnel
than more mature  companies do.  Competition  for  qualified  personnel and high
turnover of personnel are particularly  prevalent in venture capital  companies.
The  loss of one or a few key  managers  can  substantially  hinder  or  delay a
venture  capital  company's  implementation  of its business  plan. In addition,
venture  capital  companies  may not be able to  attract  and  retain  qualified
managers and personnel.

     The Fund's ability to realize value from an investment in a venture capital
company is to a large degree  dependent  upon the  successful  completion of the
company's  IPO or the sale of the venture  capital  company to another  company,
which may not occur for a period of several  years  after the date of the Fund's
investment,  if ever.  There can be no assurance that any of the venture capital
companies in which the Fund invests will complete  public  offerings or be sold,
or, if such  events  occur,  as to the timing and  values of such  offerings  or
sales.  The Fund  also may lose all or part of its  entire  investment  if these
companies  fail or their  product  lines fail to achieve  an  adequate  level of
market recognition or acceptance. Conversely, there can be no assurance that the
Fund will be able to identify a sufficient  number of desirable  venture capital
investments.

     Some companies may depend upon managerial  assistance or financing provided
by their  investors.  The Fund does not  intend to provide  any such  managerial
assistance.  However, the Fund may provide additional financing to the companies
in which it invests, and at times may be contractually  obligated to do so (that
is, its  investment  agreement  may  require  follow-on  investments  in certain
circumstances)  or may  determine  that it is  necessary to do so to protect its


                                       9
<PAGE>


economic interests.  Therefore, the value of its investments may depend upon the
quality of managerial  assistance  provided by other investors and their ability
and willingness to provide financial support. In addition,  if the Fund makes an
equity  investment  in a venture  capital  company  which has  already  received
venture capital  investments  from other sources,  the Fund's  investment may be
subordinate to such other investments.

     Depending  on the specific  facts and  circumstances  of a venture  capital
investment,  there may not be a reasonable basis to revalue it for a substantial
period of time after the Fund's  investment.  If a venture  capital company does
not  complete  an IPO or a sale to or merger  with a public  company,  there may
never be a public market benchmark for valuing the investment and it may be very
difficult  for the Fund to dispose of its  investment,  or it may be possible to
dispose of the investment only at a substantial loss. The Fund's net asset value
per share may change  substantially  in a short time as a result of developments
at the  companies  in which the Fund  invests.  Changes  in the Fund's net asset
value may be more pronounced and more rapid than with other funds because of the
Fund's emphasis on venture capital  companies that are not publicly traded.  The
Fund's  net  asset  value  per  share  may  change  materially  from day to day,
including  during the time between the date a repurchase offer is mailed and the
due date for  tendering  shares,  and  during  the  period  immediately  after a
repurchase is completed.

Investments in Venture Capital Funds

     Venture capital funds involve all the risks of investing in small companies
and  venture  capital  companies  described  in this  prospectus,  plus  certain
additional  risks.  In  particular,  the Fund must rely upon the judgment of the
general  partner or other  manager of a venture  capital fund in  selecting  the
companies in which the venture capital fund invests and in deciding when to sell
its  investments.  A venture  capital fund may employ a high degree of leverage,
which can magnify any losses  incurred by its  investors,  including the Fund. A
venture capital fund also will require its investors, including the Fund, to pay
management fees and/or performance fees or allocations to its general partner or
manager,  which can reduce the return to  investors,  including the Fund and its
shareholders. These fees are in addition to the management fee paid by the Fund.
A  venture  capital  fund  also may  incur  certain  costs  associated  with the
evaluation  of venture  capital  investments,  including  fees of outside  legal
counsel,  which may reduce the Fund's  return.  Investments  in venture  capital
funds may be highly  illiquid.  The Fund may not be able to dispose of a venture
capital  fund  holding  when  it  wishes  to,  or may be able to do so only at a
substantial loss.

Concentration; Non-Diversified Status

     The assets of the Fund will consist almost entirely of companies  within or
related to various  sectors of the life sciences and  biotechnology  industries.
Since the Fund's  portfolio will be concentrated in securities of a small number
of companies or in securities of companies in a small number of industries,  the
risk of any  investment  decision is increased.  Orbitex will seek to reduce the
company-specific  risk,  as  opposed  to  sector-specific  risk,  of the  Fund's
portfolio by investing in more than one company in a particular sector, but this
may not always be practicable.

     The Fund is classified as a "non-diversified" management investment company
under the Investment  Company Act. This means that the Fund may invest a greater
portion of its assets in a limited  number of issuers  than would be the case if
the Fund were  classified  as a  "diversified"  management  investment  company.
Accordingly,  the Fund may be  subject  to  greater  risk  with  respect  to its
portfolio  securities than a "diversified" fund because changes in the financial
condition or market assessment of a single issuer may cause greater  fluctuation
in the net asset value of the Fund's shares.

Restricted and Illiquid Securities

     The Fund  intends  to  invest a  substantial  portion  of its  assets on an
ongoing basis in restricted securities and other investments which are illiquid.
Restricted  securities  are  securities  that may not be  resold  to the  public
without an effective registration statement under the Securities Act of 1933 or,
if they are unregistered, may be sold only in a privately negotiated transaction
or pursuant to an exemption from registration.

     Restricted  and  other  illiquid  investments  involve  the  risk  that the
securities  can  not be sold  at the  time  desired  by the  Fund  or at  prices
approximating the value the Fund has determined.  Difficulty in selling illiquid
investments  could impair the Fund's ability to meet  repurchase  requests or to
pay its fees and expenses (including the management fee).


                                       10
<PAGE>


Investments in Lower-Rated Securities

     The  Fund's  investments  in  non-investment   grade  debt  securities  are
considered to be predominantly speculative with respect to the issuer's capacity
to pay interest and repay  principal.  Non-investment  grade  securities  in the
lowest rating  categories may involve a substantial risk of default or may be in
default.  Adverse changes in economic  conditions or developments  regarding the
individual  issuer  are more  likely to cause  price  volatility  and weaken the
capacity of the issuers of non-investment grade securities to make principal and
interest payments than is the case for higher grade securities. In addition, the
market for lower grade securities may be thinner and less liquid than for higher
grade securities.

Investments in Foreign Securities

     The Fund plans to invest in the  securities  of foreign  life  sciences and
biotechnology companies.  Investments in foreign securities face specific risks,
which include:

     o    unfavorable changes in currency rates and exchange control regulations

     o    restrictions on, and costs associated with, the exchange of currencies
          and the repatriation of capital invested abroad

     o    reduced availability of information regarding foreign companies

     o    foreign companies may be subject to different accounting, auditing and
          financial  standards  and to less  stringent  reporting  standards and
          requirements

     o    reduced  liquidity  as a  result  of  inadequate  trading  volume  and
          government-imposed trading restrictions

     o    the difficulty in obtaining or enforcing a judgment abroad

     o    increased   market  risk  due  to  regional   economic  and  political
          instability

     o    increased brokerage commissions and custody fees

     o    securities markets which are subject to a lesser degree of supervision
          and regulation by competent authorities

     o    foreign withholding taxes

     o    the threat of nationalization and expropriation

     o    an  increased  potential  for corrupt  business  practices  in certain
          foreign countries

Use of Derivatives for Hedging Purposes

     The Fund may use  derivative  instruments  to hedge  portfolio risk and for
cash management purposes.  Investing in derivative investments involves numerous
risks. For example:

     o    the underlying  investment or security might not perform in the manner
          that  Orbitex  expects it to  perform,  which could make the effort to
          hedge unsuccessful

     o    the company issuing the instrument may be unable to pay the amount due
          on the maturity of the instrument

     o    certain derivative  investments held by the Fund may trade only in the
          over-the-counter markets or not at all, and can be illiquid

     o    derivatives  may  change  rapidly in value  because of their  inherent
          leverage


                                       11
<PAGE>


     All of this can mean that the Fund's net asset  value may change more often
and to a greater degree than it otherwise  would.  The Fund has no obligation to
enter into any hedging transactions.

Lending of Securities

     The Fund may lend  securities from its portfolio to brokers,  dealers,  and
other financial  institutions  needing to borrow  securities to complete certain
transactions.  Although the Fund will receive  collateral in connection with all
loans of portfolio securities, and such collateral will be marked to market, the
Fund  will be  exposed  to the risk of loss  should a  borrower  default  on its
obligation to return the borrowed securities. For example, loaned securities may
have appreciated beyond the value of the collateral held by the Fund at the time
of a default. In addition, the Fund will bear the risk of loss on any collateral
that it  chooses  to  invest.  Loans  of  portfolio  securities  may not  exceed
one-third of the value of the Fund's total assets.

                                 USE OF PROCEEDS

     The Fund will invest the net  proceeds of the offering in  accordance  with
the Fund's investment objective and policies and principal strategies as soon as
practicable  after the closing of the offering.  Market  conditions  permitting,
Orbitex  expects the Fund will be fully  invested  within one year.  Pending the
full  investment  of the proceeds of the offering in securities of life sciences
and  biotechnology  companies,  the proceeds of the offering will be invested in
short-term, high quality debt securities.

                  INVESTMENT OBJECTIVE AND PRINCIPAL STRATEGIES

Investment Objective

     The Fund seeks to provide  long-term  growth of capital  through  selective
investment in the securities of life sciences and biotechnology companies of all
sizes that offer potential for growth.

Investment in Life Sciences and Biotechnology Companies

     The Fund will invest  primarily in the  securities of companies,  both U.S.
and  foreign,  primarily  engaged  in life  sciences,  pharmaceuticals,  medical
research and biotechnology research,  development and implementation,  and other
areas related to the life sciences and  biotechnology  industries.  Under normal
circumstances,  the Fund will invest at least 65% of its total  assets in equity
securities issued by life sciences companies and biotechnology  companies.  As a
matter of fundamental  policy, the Fund will concentrate (invest at least 25% of
its total  assets) in  securities  issued by companies in the life  sciences and
biotechnology industries.  The Fund will invest primarily in U.S. common stocks,
but also may invest in other types of equity securities and debt securities. The
Fund may invest up to 35% of its total  assets in debt  securities  rated  below
investment grade or unrated  securities of equivalent quality (commonly referred
to as "junk bonds"). The Fund may invest in companies of any size, but generally
expects to invest a majority of its assets in small and medium-sized  companies.
The  Fund may  invest a  significant  portion  of its  total  assets  in  equity
securities of privately  owned life sciences and  biotechnology  companies  that
plan to conduct an initial  public  offering  or IPO.  These are  referred to as
venture  capital  companies.  There will be no public market for the shares of a
venture capital company at the time of the Fund's  investment,  and there can be
no assurance that a planned IPO will ever be completed. The Fund also may invest
in private  venture  capital funds that specialize in investing in life sciences
and biotechnology companies

     The Fund will invest in companies  that Orbitex  expects to  capitalize  on
emerging changes in the life sciences and biotechnology industries.

     The Fund defines a "life sciences company" as an entity that is principally
engaged in:

     o    the design, manufacture or sale of products or services used for or in
          connection with medicine

     o    research and development of pharmaceutical  products, gene mapping and
          medical services

     o    design,  manufacture,  or sale of life  science-related  products  and
          services

     The Fund defines a "biotechnology company" as an entity that is principally
engaged in:


                                       12
<PAGE>


     o    research,  development,  manufacture or  distribution  of products and
          services relating to human health care, pharmaceuticals,  agricultural
          and veterinary applications, and the environment

     o    manufacturing  and/or  distributing  biotechnological  and  biomedical
          products, including devices, instruments and/or drug delivery systems

     The Fund also  defines a "life  sciences  or  biotechnology  company" as an
entity that is principally engaged in providing materials,  products or services
to a life sciences or biotechnology  company. The Fund considers a company to be
"principally  engaged"  in one of the  above  activities  if at least 50% of its
revenues or profits  were derived  from,  or at least 50% of its assets were in,
those activities during the company's most recent fiscal year.

     The Fund expects to invest a  substantial  portion of its assets in venture
capital companies that it determines to be in the "late-stage" (also referred to
as "mezzanine")  or "pre-IPO"  stage of development,  although from time to time
the Fund may invest in  companies  that are in the early  ("seed") or  expansion
stage of development.  These terms are explained below.  After the proceeds from
the offering are invested,  the Fund expects to continue to invest a substantial
portion of its assets in venture  capital  companies.  It is possible,  however,
that the Fund will invest only a small portion of its assets, or none at all, in
venture  capital  companies,  as  a  result  of  market  conditions,   available
opportunities and other factors.

     Seed  financing is  typically a relatively  small amount of capital used to
test a concept  so that  start-up  capital  can be  obtained;  the term also may
extend to  companies  completing  product  development  and  initial  marketing.
Typically,  a company at the seed  financing  stage has not yet sold its product
commercially.  Expansion  financing  is sought by companies  that have  expended
their initial capital (often in developing and  market-testing  a prototype) and
that require funds to initiate  full-scale  manufacturing  and sales.  Expansion
capital may also provide working capital for the initial  expansion of a company
that is  manufacturing  and shipping  its product,  but that does not yet show a
profit.  The Fund will  participate  in seed and/or  expansion  financing  for a
company only if it has an established  management  team with proven track record
of building a business and, in Orbitex's  judgment,  an innovative  product idea
with a sustainable competitive advantage. The Fund expects that companies in the
early and  expansion  stages will not  conduct an IPO for up to five years,  and
possibly substantially longer, from the time of initial investment.

     The Fund considers a venture  capital company to be in the late stage if it
has a developed  infrastructure  and has commenced  earning  revenues.  The Fund
expects that  late-stage  companies will undertake an IPO within a period of one
to three years.  A pre-IPO  company is somewhat more developed than a late-stage
company. The Fund generally would expect to acquire equity securities of pre-IPO
companies in private  placements  within a year prior to their planned IPOs. The
Fund  will  seek  late-stage  and  pre-IPO   companies  that  offer   reasonable
valuations,  especially  relative to public  companies.  Late-stage  and pre-IPO
companies typically will have small capitalizations and limited or no liquidity;
even after an IPO,  liquidity  may be  limited  and the Fund  generally  will be
subject to contractual limitations on its ability to sell shares.

     All  venture  capital  investments  involve  substantial  risks.  The risks
associated  with  investing  in  companies  in the seed or  expansion  stages of
development  are greater than those of  companies in the late or pre-IPO  stage,
because the concepts  generally  are unproven,  the companies  have little or no
track record,  and the prospect of an IPO is highly contingent upon factors that
are often not in the  companies'  control.  See  "Risk  Factors--Investments  in
Venture Capital Companies."

     Of the Fund's venture  capital  investments,  up to 10% of the Fund's total
assets may be invested in securities of investment  funds that invest  primarily
in venture capital  companies.  These  investments  may involve  relatively high
fees,  including  incentive fees (the Fund will be indirectly paying fees to the
manager  of such  investment  funds and their  other  service  providers  and to
Orbitex and the Fund's other service  providers on the same assets),  and a high
degree of risk. See "Risk Factors--Venture Capital Funds."

     The Fund also will invest in small and medium-sized  public companies.  The
common  stock of these  companies  may  trade  over-the-counter,  on the  Nasdaq
SmallCap Market,  the Nasdaq National Market,  the New York Stock Exchange,  the
American Stock Exchange or on other  markets.  Many of these  companies may have
only  recently  become  public  companies,  and  may  have  a  relatively  small
proportion of their outstanding common stock publicly traded.


                                       13
<PAGE>


Borrowing; Use of Leverage

     The Fund is  authorized  to borrow  money to fund the purchase of portfolio
securities to meet repurchase requests and for cash management purposes. The use
of  borrowings  involves  a high  degree of risk.  See "Risk  Factors--Leverage;
Borrowing."  The  Fund  generally  intends  to  borrow  money  only  in  limited
circumstances when attractive investment  opportunities are available that would
further the Fund's investment  objective and sufficient liquid resources are not
otherwise  available,  or where Orbitex believes it would not be prudent to sell
existing portfolio holdings. The Fund will not, in any event, borrow money until
the proceeds of the offering are  substantially  invested in  furtherance of the
Fund's investment objective. The Fund will seek to repay borrowings used to meet
repurchase  requests and for cash  management  purposes within one year of their
incurrence. The Fund may not borrow money to pay Fund expenses.

     The Fund will not be  permitted  to borrow for the  purpose  of  purchasing
additional  portfolio  securities at any time that borrowings  exceed 20% of its
total assets.  In addition,  the Investment  Company Act prohibits the Fund from
borrowing for any purpose if, immediately after such borrowing,  it will have an
"asset  coverage" of less than 300%.  The  Investment  Company Act also provides
that the Fund may not declare dividends or distributions,  or purchase its stock
(including in repurchase offers) if, immediately after doing so, it will have an
"asset  coverage" of less than 300%.  For this purpose,  an "asset  coverage" of
300% means  that the Fund's  total  assets  equal 300% of the total  outstanding
principal balance of indebtedness. Lenders may require the Fund to agree to more
restrictive  asset coverage  requirements as a condition to providing  credit to
the  Fund,  and may also  limit the  extent to which the Fund may hold  illiquid
securities, reducing the Fund's investment flexibility. If the Fund is unable to
make distributions as a result of these  requirements,  it may no longer qualify
as a regulated investment company and could be required to pay additional taxes.
The Fund may also be forced to sell  investments on unfavorable  terms if market
fluctuations  or other factors  reduce the asset level below what is required by
the Investment Company Act or the Fund's loan agreements.

     The Fund's willingness to borrow money, and the amount it will borrow, will
depend on many  factors,  the most  important of which are  investment  outlook,
market conditions and interest rates.  Successful use of borrowing for financial
leverage  purposes  (that is, to acquire  portfolio  securities)  will depend on
Orbitex's ability to predict correctly interest rates and market movements,  and
there is no assurance  that a borrowing  strategy will be successful  during any
period in which it is employed.

Hedging

     The Fund may seek to hedge  portfolio  risk  through  the use of  financial
instruments  known as  derivatives.  A  derivative  is  generally  defined as an
instrument  whose value is derived from, or based upon, some  underlying  index,
reference rate (such as interest rates or currency  exchange  rates),  security,
commodity or other asset.  The Fund will use a specific type of derivative  only
after consideration of, among other things, how the derivative instrument serves
the Fund's investment objective and the risk associated with the instrument. The
Fund may use  derivatives  only for the purposes of hedging  portfolio  risk and
cash management.

     The Fund may buy or sell put or call options on transferable  securities or
indices  of  securities  to hedge  against  adverse  movements  in the prices of
securities  held in the Fund's  portfolio.  The Fund's  options  strategies  may
include  the  purchase  of puts and the  simultaneous  writing  of calls  having
different  strike  prices to place a "collar"  on a portion of the Fund's  asset
value (this strategy, which involves the sale of call options to help reduce the
price of the put options, is viewed as a hedge even though the writing of a call
without the purchase of a put would not be considered hedging). The Fund may buy
or  sell  these   options  if  they  are   traded  on   options   exchanges   or
over-the-counter  markets.  However,  the Fund will only enter into transactions
with  broker-dealers  that  are  reputable  financial   institutions  which  (i)
specialize in these types of  transactions,  (ii) make markets in these options,
or (iii) are participants in  over-the-counter  markets.  A put option gives the
purchaser of the option the right to sell,  and  obligates the writer of the put
option to buy, the  underlying  security at a stated  exercise price at any time
prior to the  expiration  of the  option.  Similarly,  a call  option  gives the
purchaser of the option the right to buy, and  obligates  the writer of the call
option to sell, the underlying  security at a stated  exercise price at any time
prior to the expiration of the option.

     Orbitex will consider changes in foreign currency  exchange rates in making
investment decisions about non-U.S.  securities. As one way of managing exchange
rate  risk,  the  Fund  may  enter  into  forward  currency  exchange  contracts
(agreements  to purchase or to sell U.S.  dollars or  non-U.S.  currencies  at a
future date). A forward contract may help reduce the Fund's losses on securities
denominated  in a currency other than U.S.  dollars,  but it may also


                                       14
<PAGE>


reduce  the  potential  gain  on the  securities  depending  on  changes  in the
currency's  value  relative  to the  U.S.  dollar.  See  "Additional  Investment
Policies--Other Operating Policies--Foreign Currency Transactions" in the SAI.

Short Sales

     The Fund may engage in short sales of  securities.  To effect a short sale,
the Fund will borrow a security  from a  brokerage  firm,  or other  permissible
financial  intermediary,  to  make  delivery  to the  buyer.  The  Fund  then is
obligated to replace the borrowed  security by purchasing it at the market price
at the time of replacement.  The price at such time may be more or less than the
price at which the security  was sold by the Fund,  which would result in a loss
or gain,  respectively.  The Fund may not always be able to borrow a security it
wants to sell  short and thus  will lose the  opportunity  to  benefit  from its
strategy.  The Fund  also may be unable  to close  out a short  position  at any
particular time or at an unacceptable  price. If the Fund is required to replace
the borrowed  security at a time when other short  sellers of the same  security
also are required to replace it, a "short  squeeze" can occur,  wherein the Fund
might be compelled, at a disadvantageous time, to replace the borrowed security,
possibly at prices  significantly  in excess of the proceeds  received  from the
short sale. Although the Fund's gain on a short sale is limited to the amount at
which it sold the security short, its potential loss can increase rapidly and is
limited only by the maximum  attainable  price of the security less the price at
which the security was sold. Short selling is a speculative investment technique
and, in certain circumstances,  can substantially increase the impact of adverse
price  movements on the Fund's  portfolio.  The Fund's short sales  transactions
will not be limited by the Fund's borrowing policy described above.

Non-Diversified Status

     As a  non-diversified  investment  company,  the Fund faces few  regulatory
restrictions  on the  proportion  of its  total  assets  it  may  invest  in the
securities  of any one  company,  or on the  proportion  of its total  assets it
allocates to control interests in companies.  However,  the Fund does not intend
to  invest  more  than 25% of its  total  assets  in the  securities  of any one
company. The Fund may own a controlling  interest in one or more companies,  and
it (or it and other  funds  managed  by  Orbitex)  may own up to 100% of certain
companies.  However,  the Fund does not  intend  to invest  more than 25% of its
total assets in controlling  interests of companies.  Market  fluctuations could
cause these limits to be exceeded.

Investment Decisions Based Upon Extensive Research

     The Fund will use a bottom-up  stock  selection  approach that blends value
and growth criteria,  as well as identifies  investment and economic themes that
can drive profits.  This means that Orbitex will extensively  research  specific
companies  in the life  sciences  and  biotechnology  industries  to find  those
companies that Orbitex believes offer the greatest  prospects for future growth.
In selecting  individual  securities,  Orbitex will look for  companies  that it
believes display or are expected to display:

     o    robust growth prospects

     o    revenue-producing life sciences or biotechnological innovations

     o    high profit margins or return on capital

     o    attractive valuations relative to expected earnings or cash flow

     o    strong current or future cash flow

     o    large installed base or distribution franchise

     o    quality management

     o    favorable new product cycles

     o    unique competitive advantages, including intellectual property


                                       15
<PAGE>


Circumstances in which the Fund Will Sell a Security

     The Fund may sell those holdings that it has identified as having  exceeded
the fair  market  value  and may  sell  the  securities  of a  company  that has
experienced a fundamental  shift in its core business  processes and objectives.
The Fund also may sell the  securities  of a company  when the industry in which
the company operates has undergone a shift in focus or industry dynamics.

     The Fund also may be forced to sell  securities to meet its quarterly share
repurchase  obligation.  As a result,  the annual portfolio turnover of the Fund
may  exceed  100%.  A high  portfolio  turnover  rate will  increase  the Fund's
expenses.  On the other hand,  the Fund may invest a significant  portion of its
assets in venture capital securities having very little liquidity.  The Fund may
be  forced  to  retain  such  assets  even in  circumstances  where  the  Fund's
investment  policies indicate the assets should be sold.  Alternatively,  it may
have to sell such securities at  disadvantageous  prices in order to raise cash.
See "Risk Factors--Restricted and Illiquid Securities."

Defensive Measures

     The Fund may, from time to time, take temporary defensive positions in cash
or  short-term  debt  securities  that  are  inconsistent   with  its  principal
strategies  in an  attempt  to  moderate  extreme  volatility  caused by adverse
market,  economic,  or other  conditions.  This  could  prevent  the  Fund  from
achieving its investment objective.

                             MANAGEMENT OF THE FUND

     The board of directors  provides broad  supervision over the affairs of the
Fund.


     Orbitex Management, Inc., 410 Park Avenue, New York, New York 10022, is the
manager of the Fund.  Subject to the authority of the Fund's board of directors,
Orbitex is responsible  for the Fund's  investments  and  administers the Fund's
business and other affairs.  Orbitex was established in 1995 and employs a staff
of eight investment  management  professionals with an average experience of ten
years in the investment management business.  Orbitex is an affiliate of Orbitex
Management  Ltd., an investment  adviser that  provides  investment  services to
individuals and institutions,  including  Canadian unit trusts. As of August 31,
2000, Orbitex managed  approximately $1.024 billion in 11 mutual fund portfolios
and for institutional and other accounts.


Management Fee

     The Fund will pay a fee to Orbitex for its management services at an annual
rate of 1.75% of the Fund's  average  daily net  assets.  The fee is  calculated
daily and payable monthly.  This management fee is higher than the advisory fees
paid by most U.S. investment companies.

Portfolio Management

     The Fund will be managed  by Timothy F.  Bepler,  CFA.  Mr.  Bepler  joined
Orbitex in 1999 as a Vice President and portfolio  manager.  He brought with him
eight  years of  investment  analysis  experience  in the  healthcare  industry.
Formerly, he was a Vice President at Merrill Lynch Asset Management from 1996 to
1999 where he was a healthcare  analyst for a Growth and Income  fund.  Prior to
joining  Merrill  Lynch,  he was the sole  healthcare  analyst for a division of
Credit  Suisse from 1995 to 1996 and was a senior  analyst at Value  Line,  Inc.
from 1989-1995.

Expenses of the Fund

     The Fund pays a management  fee to Orbitex plus all its expenses other than
those  assumed by  Orbitex.  The  expenses of the Fund  include the  shareholder
servicing fee,  brokerage  commissions,  interest on any borrowings by the Fund,
fees and  expenses  of  outside  legal  counsel  (including  fees  and  expenses
associated  with  review  of  documentation  for  prospective   venture  capital
investments by the Fund) and independent auditors,  taxes and governmental fees,
custody,  expenses of printing and distributing  prospectuses,  reports, notices
(including  notices  relating  to the  quarterly  repurchase  offers)  and proxy
materials,  expenses of printing  and filing  reports and other  documents  with
government agencies,  expenses of shareholders' meetings,  expenses of corporate
data processing and related services, shareholder record keeping and shareholder
account services, fees and disbursements,  fees and expenses of directors of the
Fund  not  employed  by  Orbitex  or  its  affiliates,  insurance  premiums  and
extraordinary expenses such as litigation expenses.


                                       16
<PAGE>



     The Fund's offering expenses are estimated at $95,775 and will be paid from
the proceeds of the offering.  Organizational  expenses of approximately $50,000
will be paid by Orbitex.


Transfer Agent and Dividend Disbursing Agent


     American Data Services,  Inc. ("ADS"),  The Hauppauge Corporate Center, 150
Motor Parkway, Hauppauge, New York 11788, an affiliate of Orbitex, is the Fund's
transfer agent and dividend disbursing agent. ADS also is the Fund's shareholder
service agent, providing shareholder account services to the Fund.


                                REPURCHASE OFFERS

     The Fund  expects that a  substantial  portion of its  investments  will be
illiquid and does not intend to maintain a significant  cash position.  For this
reason,  the Fund is structured as a closed-end  fund, which means that you will
not have the right to redeem your shares on a daily basis. In addition, the Fund
does not expect any trading  market to develop for its shares.  As a result,  if
you invest in the Fund you will have limited opportunity to sell your shares.


     To provide you with a degree of  liquidity,  and the ability to receive net
asset value on a disposition of your shares, the Fund will make quarterly offers
to repurchase its shares.  The repurchase  offers will be limited to a specified
percentage of the Fund's outstanding shares. Shares will be repurchased at their
net asset value;  the Fund will not charge a repurchase fee. The Fund intends to
commence  the first  quarterly  repurchase  offer in March 2001.  The  quarterly
offers  will be made  pursuant to a  fundamental  policy of the Fund that may be
changed only with the approval of the Fund's shareholders.


The Fund Will Offer to Repurchase 5% of its Outstanding Shares Each Quarter

     Each quarter,  the Fund will offer to repurchase 5% of the number of shares
outstanding  on the date  repurchase  requests  are  due.  The  Fund's  board of
directors may establish a larger percentage for any quarterly  repurchase offer.
However,  the percentage will not be more than 25% of the shares  outstanding on
the date repurchase requests are due.


     The Fund intends to commence the first quarterly  repurchase offer in March
2001.   Thereafter,   quarterly  repurchase  offers  will  commence  each  June,
September, December and March and will be completed in the following month.


     When a repurchase offer commences, the Fund will send a notification of the
offer to shareholders via their financial intermediaries.  The notification will
specify, among other things:

     o    the  percentage  of shares that the Fund is  offering  to  repurchase,
          which will ordinarily be 5%

     o    the date on which a  shareholder's  repurchase  request is due,  which
          will ordinarily be the second Friday of the following month

     o    the date that will be used to  determine  the Fund's  net asset  value
          applicable to the share repurchase,  which is generally expected to be
          the day on which requests are due

     o    the date by which  shareholders  will receive the proceeds  from their
          share sales

     o    the net asset value of the common stock of the Fund no more than seven
          days prior to the date of the notification

     The Fund intends to send this notification approximately 30 days before the
due date for the repurchase  request.  In no event will the notification be sent
less than 21 or more than 42 days in  advance.  Your  shares of the Fund must be
held  through a  selected  broker or  dealer.  Certificated  shares  will not be
available,  and you will not be able to receive  repurchase offers directly from
the Fund. Your selected broker or dealer may require additional time to mail the
repurchase  offer to you, to process  your  request,  and to credit your account
with the proceeds of any repurchased shares.

     The due date for  repurchase  requests is a deadline  that will be strictly
observed.  If your intermediary  fails to submit your repurchase request in good
order by the due date,  you will be  unable to  liquidate  your  shares  until a
subsequent quarter,  and you will have to resubmit your request in that quarter.
You should be sure to advise your  intermediary  of your  intentions in a timely
manner.  You may withdraw or change your repurchase  request at any point before
the due date.


                                       17
<PAGE>


The Fund's Fundamental Policies with Respect to Share Repurchases

     The Fund has adopted the following  fundamental policies in relation to its
share  repurchases  which  may  be  changed  only  by a  majority  vote  of  the
outstanding voting securities of the Fund:

     o    as stated  above,  the Fund will make share  repurchase  offers  every
          three months, pursuant to Rule 23c-3 under the Investment Company Act,
          as it may be amended from time to time, commencing March 2001.

     o    5% of the  Fund's  outstanding  common  stock  will be  subject to the
          repurchase  offer,  unless  the  board  of  directors   establishes  a
          different percentage, which must be between 5% and 25%

     o    the  repurchase  request  due dates will be the second  Friday of each
          January,  April,  July and October (or the  preceding  business day if
          that day is a New York Stock Exchange holiday)

     o    there will be a maximum 14 day  period  between  the due date for each
          repurchase  request  and the date on which the Fund's net asset  value
          for that repurchase is determined

Pro Rata Purchases of Shares in the Event of an Oversubscribed Repurchase Offer

     There is no minimum number of shares that must be tendered  before the Fund
will honor repurchase requests.  However, the percentage determined by the board
of directors for each repurchase  offer will set a maximum number of shares that
may be  purchased by the Fund.  In the event a  repurchase  offer by the Fund is
oversubscribed,  the Fund may,  but is not required  to,  repurchase  additional
shares, but only up to a maximum amount of two percent of the outstanding shares
of the Fund. If the Fund determines not to repurchase  additional  shares beyond
the  repurchase  offer  amount,  or if  shareholders  tender an amount of shares
greater  than  that  which  the Fund is  entitled  to  purchase,  the Fund  will
repurchase the shares tendered on a pro rata basis.

     If pro-ration  is  necessary,  the Fund will send a notice of pro-ration to
selected  brokers and dealers on the business day  following  the due date.  The
number of shares each investor asked to have  repurchased will be reduced by the
same percentage. If any shares that you wish to have repurchased by the Fund are
not  repurchased  because  of  pro-ration,  you will have to wait until the next
repurchase  offer,  and your  repurchase  request will not be given any priority
over other  investors'  requests at this later date.  Thus, there is a risk that
the Fund may not purchase all of the shares you wish to sell in a given  quarter
or in any subsequent  quarter. In anticipation of the possibility of pro-ration,
some shareholders may tender more shares than they wish to have repurchased in a
particular quarter, thereby increasing the likelihood of pro-ration. There is no
assurance  that you will be able to sell as many of your shares as you desire to
sell.

     The  Fund  may   suspend  or  postpone  a   repurchase   offer  in  limited
circumstances,  but  only  with  the  approval  of a  majority  of the  board of
directors, including a majority of independent directors.

Determination of Repurchase Price

     The  repurchase  price  payable in respect of a  repurchased  share will be
equal to the share's net asset value on the date  specified  in the notice.  The
Fund's net asset value per share may change  substantially  in a short time as a
result of  developments  at the companies in which the Fund invests.  Changes in
the Fund's net asset value may be more pronounced and more rapid than with other
funds  because of the Fund's  emphasis on small  companies  and venture  capital
companies that are not publicly traded. The Fund's net asset value per share may
change  materially  between  the date a  repurchase  offer is mailed and the due
date, and it also may change materially shortly after a repurchase is completed.
The method by which the Fund  calculates net asset value is discussed  under the
caption "Calculation of Net Asset Value."

Payment

     The Fund expects to  repurchase  shares on the next  business day after the
net  asset  value   determination   date.   Proceeds  will  be   distributed  to
intermediaries as specified in the repurchase offer notification, usually on the
third business day after repurchase.  In any event, the Fund will pay repurchase
proceeds no later than seven days after the net asset value determination date.


                                       18
<PAGE>


Impact of Repurchase Policies on the Liquidity of the Fund

     From the time the Fund distributes each repurchase offer notification until
the net asset value  determination date, the Fund must maintain liquid assets at
least equal to the percentage of its shares subject to the repurchase offer. For
this purpose, liquid assets means assets that may be disposed of in the ordinary
course of business at approximately  the price at which they are valued or which
mature by the  repurchase  payment  date.  The Fund also is  permitted to borrow
money to meet repurchase requests.  Borrowing by the Fund involves certain risks
for shareholders. See "Risk Factors--Borrowing."

Consequences of Repurchase Offers

     The Fund believes that  repurchase  offers  generally will be beneficial to
the Fund's  shareholders,  and generally  will be funded from  available cash or
sales  of  portfolio  securities.  However,  if  the  Fund  borrows  to  finance
repurchases,  interest on that borrowing will negatively affect shareholders who
do not tender  their  shares into a repurchase  offer by  increasing  the Fund's
expenses and reducing any net investment income. To the extent the Fund finances
repurchase  proceeds by selling  Fund  investments,  the Fund will hold a larger
proportion of its total assets in highly illiquid securities.  Also, the sale of
securities  to  fund  repurchases   could  reduce  the  market  price  of  those
securities, which in turn would reduce the Fund's net asset value.

     Repurchase  offers provide  shareholders with the opportunity to dispose of
shares at net asset value.  There is no assurance that any secondary  market for
the Fund's  shares will develop,  and in the event that a secondary  market does
develop,  it is possible that shares would trade in that market at a discount to
net asset value. The existence of periodic  repurchase offers at net asset value
may not alleviate such discount.

     Repurchase  of the  Fund's  shares  will  tend  to  reduce  the  number  of
outstanding  shares and, depending upon the Fund's investment  performance,  its
net  assets.  A reduction  in the Fund's net assets  will tend to  increase  the
Fund's expense ratio.

     In addition,  the  repurchase of shares by the Fund will be a taxable event
to shareholders. For a discussion of these tax consequences, see "Taxes."

                         CALCULATION OF NET ASSET VALUE

     The Fund will  compute its net asset value on each  business  day as of the
close of regular  business of the New York Stock  Exchange,  which is  generally
4:00 p.m. New York time.  Securities owned by the Fund will be valued at current
market prices.  If reliable market prices are unavailable  (e.g., in the case of
the Fund's venture capital investments), securities will be valued at fair value
as determined in good faith in accordance with procedures approved by the Fund's
board of directors.  Venture capital  investments  will be valued at fair value,
which will be cost unless Orbitex  determines,  pursuant to the Fund's valuation
procedures,  that such a  valuation  is no longer fair or  appropriate.  In such
situations,  the Fund's  investment  will be revalued in a manner that  Orbitex,
following  procedures  approved  by the  board  of  directors,  determines  best
reflects its fair value. When the Fund holds securities of a class that has been
sold to the public,  fair valuation  would often be market value less a discount
to  reflect  contractual  or legal  restrictions  limiting  resale.  Fair  value
represents a good faith  approximation of the value of an asset and will be used
where  there is no public  market or  possibly  no market at all for a company's
securities. The fair values of one or more assets may not, in retrospect, be the
prices at which those assets could have been sold during the period in which the
particular fair values were used in determining the Fund's net asset value. As a
result,  the Fund's issuance or repurchase of its shares at net asset value at a
time when it owns  securities  that are valued at fair value may have the effect
of diluting or increasing the economic interest of existing shareholders.

     Orbitex  and the board of  directors  will  consider  numerous  factors  in
establishing a fair value for venture capital  investments.  Factors that relate
to the  securities  of a venture  capital  company  will include the cost of the
security;  the last  available  quoted  price or traded  price,  if any, for the
security;  fundamental  analytical  data relating to  transactions in comparable
securities; relationships among various securities and industry-specific indices
and evaluation of the forces which influence the market in which the security is
purchased  and sold;  the size of the Fund's  position and the  liquidity of the
market for the security; recent purchases and sales (including new issuances) of
the company's  securities;  pricing by dealers in similar  securities;  reported
prices and the extent of public trading in similar financial  instruments of the
issuer or comparable  securities;  pending public offerings by the company;  and
contractual  and  regulatory  restrictions  on  the  Fund's  disposition  of the
security.  Factors that relate to a venture  capital company itself will include
its financial


                                       19
<PAGE>


position and results of operations,  including their variance from  projections;
the  company's  business  and  financial  plan;  its  ability  to obtain  needed
financing;  changes  in  economic  conditions  affecting  the  company;  pending
reorganization activity; changes in management;  changes in contracts with major
customers and  distributors;  and changes in technology  affecting the company's
products  and  services.  Certain  developments,   such  as  changes  in  senior
management  of a  company  or its  capital  structure,  or  removal  of legal or
contractual  restrictions on sale, will cause Orbitex to review the valuation of
a company's securities  immediately.  In addition, a combination of developments
that are individually less significant also may cause a review of valuation.

     Expenses of the Fund,  including Orbitex's  management fee and the costs of
any  borrowings,  are  accrued  daily and taken into  account for the purpose of
determining net asset value.

     The net asset value per share is  computed  by  dividing  (i) the net asset
value of the Fund by (ii) the number of shares then  outstanding.  The net asset
value per share will be rounded up or down to the nearest  cent.  You may obtain
the  Fund's  daily net asset  value per  share by  calling  1-888-ORBITEX  or by
visiting  Orbitex's Internet website  (http://www.orbitexusa.com).  A listing of
the securities in the Fund's  portfolio also will be posted monthly on Orbitex's
website.  The Fund also intends to make its net asset value per share  available
for publication weekly.

                                  CAPITAL STOCK

     The Fund is authorized to issue 100 million shares of capital stock, all of
one class  called  common  stock,  $0.01 par value.  The board of  directors  is
authorized to classify and reclassify any unissued  shares of capital stock from
time to time by setting or changing the preferences, conversion or other rights,
voting  powers,  restrictions,  limitations as to dividends,  qualifications  or
terms or conditions of redemption of such shares. The board of directors is also
authorized  to increase or decrease the number of shares the Fund is  authorized
to issue.

     The  common  stock is  entitled  to one vote per share at all  meetings  of
shareholders.  The Fund does not intend to hold annual meetings of shareholders.
Common  shareholders do not have preemptive,  subscription or conversion rights,
and are not liable for further calls or  assessments.  Common  shareholders  are
entitled to receive dividends only if and to the extent declared by the board of
directors and only after the board has made  provision  for working  capital and
reserves  as it in its sole  discretion  deems  advisable.  Common  stock is not
available  in  certificated  form,  and shares  must be held  through a selected
broker or dealer.

     In general,  any action requiring a vote of the holders of the common stock
of the Fund will be effective if taken or authorized by the affirmative  vote of
a majority of the aggregate  number of the votes  entitled to vote thereon.  Any
change in the Fund's fundamental  policies may also be authorized by the vote of
67% of the votes present at a shareholders' meeting if the holders of a majority
of the aggregate  number of votes entitled to vote are present or represented by
proxy.  The Fund's charter requires the affirmative vote of 67% of the aggregate
number of votes  entitled to be cast to authorize any of the  following  actions
unless such action has been approved by a two-thirds vote of the entire board of
directors:  (i) a merger or consolidation of the Fund; (ii) certain sales of all
or substantially all of the Fund's assets;  (iii) the liquidation or dissolution
of the Fund;  (iv) the  conversion  of the Fund into an  open-end  fund;  (v) an
increase in the maximum number of directors  specified in the charter;  (vi) the
removal  of a  director;  or (vii) an  amendment  of the  charter  to reduce the
two-thirds  vote required to authorize the actions listed in this  sentence.  In
addition,  the Fund's bylaws provide,  among other things, that: nominations for
directors and other  stockholder  proposals  must be made within  specified time
frames in advance of an annual or special  meeting of  stockholders  and must be
accompanied by specified  information;  special  meetings of stockholders may be
called at the written request of  stockholders  holding not less than 50% of the
votes entitled to be cast at such a meeting; and only the board of directors may
amend the  bylaws.  Some of the  foregoing  could have the  effect of  delaying,
deferring or preventing changes in control of the Fund.

     In the event of any voluntary or  involuntary  liquidation,  dissolution or
winding up of the Fund, after payment of all of the liabilities of the Fund, the
common shareholders are entitled to share ratably in all the remaining assets of
the Fund.

                               DISTRIBUTION POLICY

     Dividends will be paid annually on the common stock in amounts representing
substantially  all of the net  investment  income,  if any,  earned  each  year.
Payments on the common stock will vary in amount, depending on investment income
received and expenses of  operation.  It is likely that many of the companies in
which the Fund


                                       20
<PAGE>


invests will not pay any dividends, and this, together with the Fund's expenses,
means that the Fund is unlikely to have income or pay dividends. The Fund is not
a suitable investment if you require regular dividend income.

     Substantially  all of any taxable net capital gain realized on  investments
will be paid to common shareholders at least annually.

     In addition,  depending upon the performance of the Fund's investments, the
related  growth of the Fund's net assets,  and the  availability  of  attractive
investment  opportunities,  the Fund may from time to time  make a  distribution
that  constitutes  a return of capital  for  federal  income tax  purposes.  See
"Taxes."

     The net  asset  value of each  share  that you own will be  reduced  by the
amount of the distributions or dividends that you receive from that share.

Automatic Reinvestment Plan

     The automatic  reinvestment  plan is available for any holder of the Fund's
common stock who wishes to purchase  additional  shares using  dividends  and/or
capital gain distributions paid by the Fund. You may elect to:

     o    reinvest 100% of both dividends and capital gain distributions;

     o    receive dividends in cash and reinvest capital gain distributions; or

     o    receive both dividends and capital gain distributions in cash.

     Your   dividends  and  capital  gain   distributions   will  be  reinvested
automatically if you do not instruct your broker or dealer  otherwise.  The Fund
may limit the extent to which any distributions  that are returns of capital may
be reinvested in the Fund.

     Shares  will be issued to you at their net asset  value on the  ex-dividend
date; there is no sales charge or other charge for reinvestment. You are free to
change your election at any time by contacting  your broker or dealer,  who will
inform the Fund.  Your  request  must be  received by the Fund before the record
date to be effective for that dividend or capital gain distribution.

     The Fund reserves the right to suspend the automatic  reinvestment  plan at
any time and require shareholders to receive all distributions in cash. The Fund
also may limit the  maximum  amount that may be  reinvested,  either as a dollar
amount or as a percentage of  distributions.  The Fund currently does not expect
to suspend or limit the reinvestment  plan, but it may determine to do so if the
amount  being  reinvested  by  shareholders  exceeds  the  available  investment
opportunities that Orbitex considers suitable for the Fund.

     For additional  information about the Fund's automatic  reinvestment  plan,
you may call  1-888-ORBITEX or contact ADS, The Hauppauge  Corporate Center, 150
Motor Parkway, Hauppauge, New York 11788.

Distributions in-Kind

     The Fund reserves the right to make any distributions  in-kind (that is, to
distribute  securities from its portfolio  instead of cash).  However,  the Fund
currently does not intend to make any in-kind distributions, and only securities
that are freely transferable will be distributed in-kind.

                                      TAXES

     The Fund  intends  to  qualify  and  elect  to be  treated  as a  regulated
investment  company under the Internal  Revenue Code. As a regulated  investment
company,  the Fund will  generally  be exempt from  federal  income taxes on net
investment  income and capital gain distributed to  shareholders,  as long as at
least 90% of the Fund's investment  income and net short-term  capital gains are
distributed to shareholders each year.

     Dividends from net investment income and distributions  from net short-term
capital gain are taxable as ordinary  income and, to the extent  attributable to
dividends received by the Fund from U.S. corporations, may be eligible for a 70%
dividends-received   deduction   for   shareholders   that   are   corporations.
Distributions  from net capital  gain are  taxable as  long-term  capital  gain,
regardless of how long shares in the Fund have been held by the shareholder, and
are not  eligible for the  dividends-received  deduction.  The tax  treatment of
dividends  and capital gain  distributions  is the same whether you take them in
cash or reinvest them to buy additional Fund shares.


                                       21
<PAGE>


     When you sell Fund shares or have shares  repurchased by the Fund, any gain
or loss you realize  will  generally  be treated as a long-term  capital gain or
loss if you held your shares for more than one year, or as a short-term  capital
gain or loss if you held your shares for one year or less.  However, if you sell
Fund shares on which a long-term capital gain distribution has been received and
you held the shares for six months or less, any loss you realize will be treated
as a long-term  capital loss to the extent that it offsets the long-term capital
gain distribution.

     The Fund does not intend to operate so as to be permitted to "pass-through"
to its shareholders credit for foreign taxes, if any, payable by the Fund.

     Each  January,  you  will be sent  information  on the  tax  status  of any
distribution made during the previous calendar year.  Because each shareholder's
situation is unique,  you should always consult your tax adviser  concerning the
effect income taxes may have on your individual investment.

                                  DISTRIBUTION


     Funds Distributor,  Inc., 60 State Street, Boston, Massachusetts 02109, and
Orbitex Funds Distributor,  Inc., 410 Park Avenue, New York, New York 10022, are
the  co-distributors of the Fund's shares.  Funds Distributor,  Inc. has entered
into selected dealer  agreements  with various dealers (the "Selected  Dealers")
that have  agreed to use their  best  efforts  to sell the  Fund's  shares.  The
Selected  Dealers are required to pay for only the  securities  they sell to the
public and have no obligation to sell any specific number of Fund shares.

     The Selected  Dealers will solicit  subscriptions  for Fund shares from the
date  hereof  until  November  3,  2000  (the  "Subscription  Period"),   unless
accelerated or extended by the Fund in its sole discretion.  Subscriptions  will
be payable on the business day following  the  termination  of the  Subscription
Period (the "Closing Date"), at which time the Fund will commence operations. In
addition,  during the 90-day  period  following  the Closing  Date or such other
period  of time as may be  determined  by the Fund in its sole  discretion  (the
"Continuous  Offering  Period"),  the Fund will  continuously  offer its  shares
through the Selected Dealers.


     During the Subscription  Period, the public offering price of the shares to
investors  shall be $25.00 per share plus the sales charge equal to 4% (4.16% of
the net amount  invested).  The Selected Dealers will be entitled to receive the
amount  of  the  sales  charge  in  respect  of  Fund  shares  sold  during  the
Subscription Period.

     During the Continuous  Offering  Period,  the public  offering price of the
shares to investors  shall be the Fund's then current net asset value per share,
determined  by the Fund or any agent of the Fund in  accordance  with the method
set forth above under  "Calculation  of Net Asset  Value," plus the sales charge
equal to 4% (4.16% of the net amount  invested).  The  Selected  Dealers will be
entitled  to receive  the amount of the sales  charge in respect of Fund  shares
sold during the Continuous Offering Period.




     OFD, in its sole discretion,  may pay all or a portion of the placement fee
to certain Selected Dealers.


     Fund shares may be sold without a sales charge to the directors,  trustees,
officers  and  employees  of the  Fund,  a fund in the  Orbitex  Group of Funds,
Orbitex or its affiliates,  a Selected  Dealer,  such persons'  immediate family
members,  and partners and  employees  of outside  legal  counsel to the Fund or
other funds managed by Orbitex.

Future Offerings

     After the end of the Continuous  Offering Period, the Fund may from time to
time offer  additional  shares to investors,  depending upon market  conditions,
available  investment  opportunities  and  other  factors,  but the  Fund has no
current plans for any future offerings. Orbitex may sponsor other funds that are
similar to the Fund in the future.

Shareholder Servicing Fee


     The  Fund  intends  to  pay  Selected  Dealers  that  have  entered  into a
shareholder  servicing  agreement  with Funds  Distributor,  Inc. a  shareholder
servicing fee to  compensate  them for  providing  shareholder  services and the
maintenance of accounts.  These services include  responding to client inquiries
about  the Fund or their  share  position  in the Fund,  forwarding  shareholder
communications  to  clients,  assisting  clients in changing  dividend  options,
account  designations  or  addresses,  and  assisting in  processing  repurchase
requests. The shareholder servicing fee is payable at an annual rate of 0.25% of
the value of the outstanding shares owned by customers of such broker or dealer.
This fee is accrued daily as an expense of the Fund.



                                       22
<PAGE>


                               GENERAL INFORMATION

     The Fund is registered  under the  Investment  Company Act as a closed-end,
non-diversified  management  investment company. The Fund was incorporated under
the laws of the State of Maryland on April 6, 2000 and has no operating history.
The Fund's  office is  located  at The  Hauppauge  Corporate  Center,  150 Motor
Parkway,  Hauppauge,  NY 11788.  The telephone  number for sales  information is
1-877-246-8282   and  the  telephone   number  for  servicing   information   is
1-888-ORBITEX.  Investment advisory services are provided to the Fund by Orbitex
Management,  Inc. The Fund's transfer agent is American Data Services,  Inc., an
affiliate of Orbitex.


                                       23
<PAGE>


                            TABLE OF CONTENTS OF SAI

Additional Investment Policies...............................................B-2
Directors and Officers.......................................................B-7
Investment Advisory and Other Services......................................B-12
Experts.....................................................................B-13
Custodian, Transfer Agent and Dividend Disbursing Agent.....................B-13
Brokerage Commissions.......................................................B-13
Financial Statement and Report of Independent Accountants...................B-14



                                       24
<PAGE>


                                     ORBITEX

                    LIFE SCIENCES & BIOTECHNOLOGY FUND, INC.


                The Happauge Corporate Center, 150 Motor Parkway,
                            Happauge, New York 11788
                                A Management Type
                           Non-Diversified, Closed-End
                               Investment Company



                                  COMMON STOCK
                                ($0.01 PAR VALUE)


                                   PROSPECTUS



                                 OCTOBER 2, 2000



     Until  December 31, 2000 (90 calendar  days after the  commencement  of the
offering),  all  dealers  that buy,  sell or trade the  shares,  whether  or not
participating in the offering, may be required to deliver a prospectus.




     INVESTMENT MANAGER                       SHAREHOLDER SERVICE AGENT
     Orbitex Management, Inc.                 American Data Services, Inc.
     410 Park Avenue                          The Hauppauge Corporate Center
     New York, New York 10022                 150 Motor Parkway
                                              Hauppauge, New York  11788

     CUSTODIAN                                GENERAL COUNSEL
     Circle Trust Company                     Clifford Chance Rogers & Wells LLP
     Metro Center                             200 Park Avenue
     One Station Place                        New York, New York 10166
     Stamford, Connecticut 06902

<PAGE>


                ORBITEX LIFE SCIENCES & BIOTECHNOLOGY FUND, INC.




                                 OCTOBER 2, 2000


                       STATEMENT OF ADDITIONAL INFORMATION


                         The Hauppauge Corporate Center
                                150 Motor Parkway
                            Hauppauge, New York 11788
                                  1-888-ORBITEX


     THIS STATEMENT OF ADDITIONAL INFORMATION ("SAI") IS NOT A PROSPECTUS.  THIS
SAI RELATES TO AND SHOULD BE READ IN CONJUNCTION  WITH THE PROSPECTUS OF ORBITEX
LIFE SCIENCES & BIOTECHNOLOGY FUND, INC. (THE "FUND"),  DATED OCTOBER 2, 2000. A
COPY OF THE  PROSPECTUS  MAY BE OBTAINED BY CONTACTING THE FUND AT THE TELEPHONE
NUMBER OR ADDRESS SET FORTH ABOVE.


     THE  INFORMATION  IN THIS SAI IS NOT COMPLETE AND MAY BE CHANGED.  THE FUND
MAY NOT SELL THESE SECURITIES  UNTIL THE  REGISTRATION  STATEMENT FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION (THE "COMMISSION") IS EFFECTIVE.  THIS SAI IS
NOT AN OFFER TO SELL THESE SECURITIES AND THE FUND IS NOT SOLICITING AN OFFER TO
BUY THESE SECURITIES IN ANY STATE WHERE THE OFFER OR SALE IS NOT PERMITTED.


                                TABLE OF CONTENTS


Additional Investment Policies..............................................B-2
Directors and Officers......................................................B-8
Investment Advisory and Other Services......................................B-9
Experts....................................................................B-10
Custodian, Transfer Agent and Dividend Disbursing Agent....................B-10
Brokerage Commissions......................................................B-10
Additional Information.....................................................B-11
Financial Statement and Report of Independent Accountants..................B-13



                                      B-1
<PAGE>


                         ADDITIONAL INVESTMENT POLICIES

     The Fund seeks to provide  long-term  growth of capital  through  selective
investment in the securities of life sciences and biotechnology companies of all
sizes that offer  potential  for growth.  The Fund will invest  primarily in the
securities  of  companies,  both U.S.  and  foreign,  primarily  engaged in life
sciences,   pharmaceuticals,   medical  research  and  biotechnology   research,
development and implementation, and other areas related to the life sciences and
biotechnology industries. A company that is "primarily engaged" in life sciences
or biotechnology is one that either derives at least 50% of its revenue from, or
has at least 50% of its assets in, life sciences or biotechnology activities.

     Certain additional investment information is set forth below.

FUNDAMENTAL POLICIES

     The Fund's stated  fundamental  policies,  which may only be changed by the
affirmative vote of a majority of the outstanding voting securities of the Fund,
are listed below.  Within the limits of these fundamental  policies,  the Fund's
management  has  reserved  freedom  of  action.  For the  purposes  of this SAI,
"majority of the outstanding  voting  securities of the Fund" means the vote, at
an annual or special meeting of  securityholders  duly called, (a) of 67 percent
or more of the voting securities present at such meeting, if the holders of more
than 50 percent of the outstanding  voting securities of the Fund are present or
represented by proxy; or (b) of more than 50 percent of the  outstanding  voting
securities of the Fund, whichever is the less. The Fund:

          (1)  May not purchase  securities on margin,  except the Fund may make
               margin  deposits  in  connection  with  permissible  options  and
               futures   transactions  subject  to  (5)  below  and  may  obtain
               short-term   credits  as  may  be  necessary   for  clearance  of
               transactions.

          (2)  May not issue any class of  securities  senior to any other class
               of securities  except in compliance  with the Investment  Company
               Act of 1940, as amended (the "1940 Act").

          (3)  May not borrow money for investment purposes in excess of 33-1/3%
               of the value of its total assets,  including any amount  borrowed
               less its  liabilities  not  including  any such  borrowings.  Any
               borrowings,  which come to exceed this amount, will be reduced in
               accordance with applicable law.

          (4)  May not  purchase or sell real  estate,  or invest in real estate
               limited partnerships.

          (5)  May  not  purchase  or sell  physical  commodities  or  contracts
               thereon,  except that the Fund may enter into  financial  futures
               contracts and options thereon.

          (6)  May not underwrite securities issued by other persons,  except to
               the  extent  that the Fund may be  deemed  to be an  underwriter,
               within the meaning of the Securities Act of 1933, as amended (the
               "Securities  Act"), in connection with the purchase of securities
               directly from an issuer.

          (7)  May not make loans,  except that the Fund may:  (i) invest in all
               or a portion of an issue of publicly  issued or privately  placed
               bonds,   debentures,   notes,  other  debt  securities  and  loan
               participation  interests for investment  purposes;  (ii) purchase
               money market securities and enter into repurchase agreements; and
               (iii) lend its  portfolio  securities  in an amount not exceeding
               one-third of the value of the Fund's total assets.

          (8)  With respect to its share repurchases:

               o    the Fund will  make  share  repurchase  offers  every  three
                    months (except under


                                       2
<PAGE>


                    the  circumstances   described  below  in  "Other  Operating
                    Policies  -- Share  Repurchases"),  commencing  March  2001,
                    pursuant  to Rule  23c-3  under the 1940  Act,  as it may be
                    amended from time to time;

               o    5% of the Fund's outstanding common stock will be subject to
                    each  repurchase  offer,   unless  the  board  of  directors
                    establishes a different percentage, which must be between 5%
                    and 25%;

               o    the  repurchase  request due dates will be the second Friday
                    of each January,  April,  July and October (or the preceding
                    business  day if  that  day  is a New  York  Stock  Exchange
                    holiday); and

               o    there will be a maximum 14 day period  between  the due date
                    for each repurchase request and the date on which the Fund's
                    net asset value for that repurchase is determined.

          (9)  May not  invest  more  than 25% of its  total  assets  in any one
               industry,  except  that the Fund will  invest at least 65% of the
               value  of  its  total  assets  in  securities  of  life  sciences
               companies and biotechnology companies,  except when investing for
               temporary defensive purposes.

OTHER OPERATING POLICIES

     Lending of Portfolio  Securities.  During the time portfolio securities are
on loan,  the borrower  will pay the Fund any  dividends or interest paid on the
securities.  The Fund may invest the  collateral and earn  additional  income or
receive an agreed upon amount of interest  income from the borrower.  Loans made
by the Fund will  generally be  short-term.  Loans are subject to termination at
the  option  of  the  Fund  or  the  borrower.   The  Fund  may  pay  reasonable
administrative  and  custodial  fees  in  connection  with a loan  and may pay a
negotiated  portion of the interest  earned on the collateral to the borrower or
placing broker. The Fund does not have the right to vote securities on loan, but
would  terminate  a loan and  regain  the right to vote if that were  considered
important with respect to the investment.  The Fund may lose money if a borrower
defaults on its obligation to return  securities and the value of the collateral
held by the Fund is insufficient to replace the loaned securities.  In addition,
the Fund is  responsible  for any loss that might result from its  investment of
the borrower's collateral.

     Foreign   Securities.   The  Fund  may  invest  in  commercial   paper  and
certificates  of deposit issued by foreign banks and may invest either  directly
or through American Depositary  Receipts ("ADRs"),  European Depositary Receipts
("EDRs"),  or Global  Depositary  Receipts ("GDRs")  (collectively,  "depositary
receipts") in other securities of foreign issuers. For a discussion of the risks
associated with investments in foreign  securities,  see "Risk  Factors--Foreign
Securities" in the Prospectus.

     Depositary  receipts are instruments  generally issued by domestic banks or
trust  companies that represent the deposits of a security of a foreign  issuer.
ADRs,  which are traded in dollars on U.S.  exchanges or  over-the-counter,  are
issued by domestic banks and evidence  ownership of securities issued by foreign
corporations.  EDRs are typically traded in Europe. GDRs are typically traded in
both  Europe and the United  States.  Depositary  receipts  may be issued  under
sponsored or unsponsored  programs.  In sponsored programs,  the issuer has made
arrangements to have its securities traded in the form of a depositary  receipt.
In  unsponsored  programs,  the  issuers  may not be  directly  involved  in the
creation  of the  program.  Although  regulatory  requirements  with  respect to
sponsored and unsponsored depositary receipt programs are generally similar, the
issuers of securities  represented  by unsponsored  depositary  receipts are not
obligated to disclose material  information in the United States, and therefore,
the import of such  information may not be reflected in the market value of such
receipts.  The  Fund  may  invest  up to


                                       3
<PAGE>


25% of its total  assets in foreign  securities  that it holds  directly  (which
limitation may be changed without a shareholder  vote),  but this 25% limit does
not apply to foreign  securities  held  through  depositary  receipts  which are
traded in the United States or to commercial  paper and  certificates of deposit
issued by foreign banks.

     Investment  income  received  by  the  Fund  from  sources  within  foreign
countries  may be subject to foreign  income taxes  withheld at the source.  The
United  States has entered into tax treaties with many foreign  countries  which
entitle the Fund to a reduced rate of such taxes or exemption from taxes on such
income.  It is  impossible  to determine  the  effective  rate of foreign tax in
advance  since the amounts of the Fund's  assets to be invested  within  various
countries is not known.

     Rights  and  Warrants.  The Fund may  invest in  common  stock  rights  and
warrants  believed by Orbitex  Management,  Inc.  ("Orbitex") to provide capital
appreciation  opportunities.  Common  stock rights and warrants may be purchased
separately  or may be  received  as  part of a unit or  attached  to  securities
purchased.

     Derivatives.  The Fund may seek to hedge  portfolio risk through the use of
financial instruments known as derivatives. A derivative is generally defined as
an instrument whose value is derived from, or based upon, some underlying index,
reference rate (such as interest rates or currency  exchange  rates),  security,
commodity or other asset.  The Fund will use a specific type of derivative  only
after consideration of, among other things, how the derivative instrument serves
the Fund's investment objective and the risk associated with the instrument. The
Fund may use  derivatives  only for the purposes of hedging  portfolio  risk and
cash management.

Options

     The Fund may buy or sell put and call options if they are traded on options
exchanges or over-the-counter  markets.  However,  the Fund will only enter into
transactions with broker-dealers that are reputable financial institutions which
(i)  specialize  in these  types of  transactions,  (ii) make  markets  in these
options, or (iii) are participants in over-the-counter markets.

     Purchasing a put option gives the Fund the right to sell, and obligates the
writer to buy, the underlying  security at the exercise price at any time during
the option period. Purchasing a call option gives the Fund the right to buy, and
obligates the writer of the call option to sell,  the  underlying  security at a
stated exercise price at any time prior to the expiration of the option. Because
an option gives the  purchaser a right and not an  obligation,  the purchaser is
not  required to exercise the option.  The option right is available  during the
life of the option.

     When the Fund  purchases an option,  it is required to pay a premium to the
party writing the option and a commission to the broker selling the option.  The
Fund's maximum financial exposure will be limited to these costs. In order for a
put option to be profitable,  the market price of the  underlying  security must
decline  sufficiently  below  the  exercise  price  to  cover  the  premium  and
transaction  costs.  Conversely,  a call option will be profitable if the market
price of the underlying  security rises sufficiently above the exercise price to
cover the premium and transaction  costs. If an option is exercised by the Fund,
the  premium  and the  commission  paid may be  greater  than the  amount of the
brokerage  commission  charged  if the  security  were to be  purchased  or sold
directly.

     The Fund may purchase both listed and  over-the-counter  options.  The Fund
will be  exposed  to the  risk of  counterparty  nonperformance  in the  case of
over-the-counter options.

     Options on securities may not be available to the Fund on reasonable  terms
in many  situations and the Fund may frequently  choose not to purchase  options
even  when  they  are  available.   The  Fund's  ability  to  engage  in  option
transactions may be limited by tax considerations.


                                       4
<PAGE>


Futures

     The Fund may engage in transactions in futures and options thereon. Futures
are standardized,  exchange-traded  contracts which obligate a purchaser to take
delivery,  and a seller to make delivery, of a specific amount of a commodity at
a specified  future date at a specified  price.  No price is paid upon  entering
into a futures contract.  Rather,  upon purchasing or selling a futures contract
the Fund is  required to deposit  collateral  ("margin")  equal to a  percentage
(generally less than 10%) of the contract value.  Each day thereafter  until the
futures position is closed, the Fund will pay additional margin representing any
loss  experienced  as a result  of the  futures  position  the  prior  day or be
entitled to a payment  representing  any profit  experienced  as a result of the
futures position the prior day.

     The sale of a futures  contract  limits the Fund's  risk of loss  through a
decline in the market value of portfolio  holdings  correlated  with the futures
contract  prior to the  futures  contract's  expiration  date.  In the event the
market value of the  portfolio  holdings  correlated  with the futures  contract
increases  rather than decreases,  however,  the Fund will realize a loss on the
futures  position and a lower return on the  portfolio  holdings than would have
been realized without the purchase of the futures contract.

     The purchase of a futures  contract may protect the Fund from having to pay
more for  securities as a consequence  of increases in the market value for such
securities  during a period when the Fund was  attempting  to identify  specific
securities in which to invest in a market the Fund believes to be attractive. In
the event that such  securities  decline in value or the Fund  determines not to
complete an  anticipatory  hedge  transaction  relating  to a futures  contract,
however, the Fund may realize a loss relating to the futures position.

     The Fund will  limit  transactions  in  futures  and  options on futures to
financial futures contracts (i.e.,  contracts for which the underlying commodity
is a currency or  securities  or  interest  rate  index)  purchased  or sold for
hedging purposes (including  anticipatory  hedges).  The Fund will further limit
transactions  in futures  and  options on  futures  to the extent  necessary  to
prevent the Fund from being deemed a "commodity  pool" under  regulations of the
Commodity Futures Trading Commission.

     Foreign Currency Transactions. A forward foreign currency exchange contract
is an agreement to purchase or sell a specific  currency at a future date and at
a price set at the time the contract is entered  into.  The Fund will  generally
enter into forward foreign  currency  exchange  contracts to fix the U.S. dollar
value of a security it has agreed to buy or sell for the period between the date
the trade was entered into and the date the security is delivered  and paid for,
or, to hedge the U.S. dollar value of securities it owns.

     Where  the  Fund  believes  that  a  foreign   currency  may  experience  a
substantial  movement against the U.S. dollar, the Fund may enter into a forward
contract to sell or buy an  appropriate  amount of that  foreign  currency.  The
contract  would  approximate  the value of some or all of the  Fund's  portfolio
securities denominated in such foreign currency. Under normal circumstances, the
portfolio manager will limit forward currency  contracts to not greater than 75%
of the Fund's portfolio  position in any one country as of the date the contract
is entered  into.  This  limitation  will be  measured  at the point the hedging
transaction  is entered  into by the Fund.  Under  extraordinary  circumstances,
Orbitex may enter into forward currency contracts in excess of 75% of the Fund's
portfolio  position  in any one  country as of the date the  contract is entered
into.  The precise  matching of the  forward  contract  amounts and the value of
securities  involved  will not  generally be possible  since the future value of
such  securities in foreign  currencies  will change as a consequence  of market
movement in the value of those securities  between the date the forward contract
is entered into and the date it matures.  The projection of short-term  currency
market  movement is  extremely  difficult,  and the  successful  execution  of a
short-term  hedging strategy is highly uncertain.  Under certain  circumstances,
the Fund may commit up to the entire value of its assets  which are  denominated
in foreign  currencies  to the  consummation  of these  contracts.  Orbitex will


                                       5
<PAGE>


consider the effect a  substantial  commitment  of the Fund's  assets to forward
contracts  would have on the  investment  program of the Fund and its ability to
purchase additional securities.

     Except as set forth above and  immediately  below,  the Fund will not enter
into such forward  contracts or maintain a net exposure to such contracts  where
the  consummation of the contracts would oblige the Fund to deliver an amount of
foreign  currency in excess of the value of the Fund's  portfolio  securities or
other assets  denominated in that  currency.  The Fund, in order to avoid excess
transactions and transaction  costs, may nonetheless  maintain a net exposure to
forward  contracts in excess of the value of the Fund's portfolio  securities or
other  assets  denominated  in that  currency  provided  the  excess  amount  is
"covered" by cash or liquid,  high-grade  debt  securities,  denominated  in any
currency, at least equal at all times to the amount of such excess. Under normal
circumstances,  consideration  of the  prospect for  currency  parities  will be
incorporated  into the  longer-term  investment  decisions  made with  regard to
overall  diversification  strategies.  However,  Orbitex  believes  that  it  is
important to have the  flexibility to enter into such forward  contracts when it
determines that the best interests of the Fund will be served.

     At the  maturity  of a  forward  contract,  the  Fund may  either  sell the
portfolio  security and make delivery of the foreign currency,  or it may retain
the security and  terminate  its  contractual  obligation to deliver the foreign
currency by purchasing an "offsetting"  contract  obligating it to purchase,  on
the same maturity date, the same amount of the foreign currency.

     As indicated  above,  it is impossible to forecast with absolute  precision
the market  value of  portfolio  securities  at the  expiration  of the  forward
contract.  Accordingly,  it may be necessary for the Fund to purchase additional
foreign  currency on the spot market (and bear the expense of such  purchase) if
the market value of the security is less than the amount of foreign currency the
Fund is  obligated to deliver and if a decision is made to sell the security and
make delivery of the foreign currency.  Conversely,  it may be necessary to sell
on the spot market some of the foreign  currency  received  upon the sale of the
portfolio  security if its market value  exceeds the amount of foreign  currency
the Fund is obligated to deliver.  However, the Fund may use liquid,  high-grade
debt securities,  denominated in any currency,  to cover the amount by which the
value of a forward  contract  exceeds  the value of the  securities  to which it
relates.

     If the Fund  retains  the  portfolio  security  and  engages in  offsetting
transactions,  the Fund will incur a gain or a loss (as described  below) to the
extent that there has been  movement  in forward  contract  prices.  If the Fund
engages  in an  offsetting  transaction,  it may  subsequently  enter into a new
forward  contract to sell the foreign  currency.  Should  forward prices decline
during the period  between the Fund's  entering into a forward  contract for the
sale of a foreign  currency and the date it enters into an  offsetting  contract
for the  purchase of the foreign  currency,  the Fund will realize a gain to the
extent the price of the  currency it has agreed to sell exceeds the price of the
currency it has agreed to purchase.  Should  forward prices  increase,  the Fund
will  suffer a loss to the  extent  the price of the  currency  it has agreed to
purchase exceeds the price of the currency it has agreed to sell.

     The Fund's dealing in forward foreign currency  exchange  contracts will be
limited to the transactions described above. Of course, the Fund is not required
to enter into forward contracts with regard to its foreign  currency-denominated
securities  and will not do so unless  deemed  appropriate  by Orbitex.  It also
should be realized that this method of hedging against a decline in the value of
a currency  does not  eliminate  fluctuations  in the  underlying  prices of the
securities.  It  simply  establishes  a  rate  of  exchange  at a  future  date.
Additionally, although such contracts tend to minimize the risk of loss due to a
decline in the value of a hedged currency,  at the same time, they tend to limit
any  potential  gain which  might  result  from an increase in the value of that
currency.

     Stockholders should be aware of the costs of currency conversion.  Although
foreign exchange  dealers do not charge a fee for conversion,  they do realize a
profit based on the difference  (the "spread")  between the prices at which they
are buying and selling  various  currencies.  Thus, a dealer may offer to


                                       6
<PAGE>


sell a foreign currency to the Fund at one rate, while offering a lesser rate of
exchange should the Fund desire to resell that currency to the dealer.

     Repurchase  Agreements.  The Fund may enter into repurchase agreements with
commercial  banks and  broker-dealers  as a short-term cash  management  tool. A
repurchase  agreement is an agreement  under which the Fund acquires a security,
generally  a U.S.  Government  obligation,  subject to resale at an agreed  upon
price and date. The resale price reflects an agreed upon interest rate effective
for the  period of time the Fund  holds the  security  and is  unrelated  to the
interest  rate on the security.  The Fund's  repurchase  agreements  will at all
times be fully collateralized.

     Repurchase   agreements  could  involve  certain  risks  in  the  event  of
bankruptcy  or other  default  by the  seller,  including  possible  delays  and
expenses in liquidating  the securities  underlying the agreement,  a decline in
value of the underlying securities and a loss of interest. Repurchase agreements
are  typically  entered into for periods of one week or less.  The Fund will not
enter into  repurchase  agreements of more than one week's duration if more than
10% of its total assets would be so invested.

     Short  Sales.  The Fund may sell  securities  short as part of its  overall
portfolio management strategy involving the use of derivative instruments and to
offset potential declines in long positions in similar securities.  A short sale
is a transaction  in which the Fund sells a security it does not own or have the
right to acquire (or that it owns but does not wish to deliver) in  anticipation
that the market price of that security will decline.

     Restricted  or  Illiquid  Securities.  The  Fund  may  invest  in  illiquid
securities,  including  restricted  securities  (i.e.,  securities  not  readily
marketable  without  registration under the Securities Act) and other securities
that are not readily  marketable.  These may include restricted  securities that
can be offered and sold only to "qualified institutional buyers" under Rule 144A
of the Securities Act. The Fund's  investments in venture capital companies will
generally be illiquid,  although a venture capital  investment may become liquid
if the company  completes an IPO and any contractual  restrictions on the Fund's
ability to sell its shares terminate. There is no limit to the percentage of the
Fund's  total  assets that may be invested in illiquid  securities,  but Orbitex
does not expect  that  illiquid  securities  will  ordinarily  exceed 50% of the
Fund's total assets.  The Fund will not make new venture capital  investments at
any time when its existing venture capital  investments  exceed 50% of its total
assets, but the Fund may, at such times, make additional  investments in venture
capital companies already represented in its portfolio.

     Debt Securities.  The Fund may invest up to 35% of its total assets in debt
securities  which are not rated within the four  highest  rating  categories  by
Standard & Poor's Ratings Group or Moody's Investors Services, Inc.

     Temporary Defensive  Position.  In an attempt to respond to adverse market,
economic,  political, or other conditions, the Fund may invest up to 100% of its
total assets in cash or cash  equivalents  including,  but not limited to, prime
commercial  paper,  bank  certificates  of  deposit,   bankers'  acceptances  or
repurchase agreements for such securities, and securities of the U.S. Government
and its agencies  and  instrumentalities,  as well as cash and cash  equivalents
denominated  in foreign  currencies.  The  Fund's  investments  in foreign  cash
equivalents  will be limited to those that,  in the  opinion of Orbitex,  equate
generally to the standards established for U.S. cash equivalents. Investments in
bank obligations will be limited at the time of investment to the obligations of
the 100  largest  domestic  banks  in terms  of  assets  which  are  subject  to
regulatory  supervision  by the U.S.  Government or state  governments,  and the
obligations of the 100 largest foreign banks in terms of assets with branches or
agencies in the United States.

     Share Repurchases.  The Fund may not suspend or postpone a repurchase offer
except  pursuant to a vote of a majority of the directors,  including a majority
of the disinterested directors, and only:


                                       7
<PAGE>


          o    If the  repurchase  would  cause the Fund to lose its status as a
               regulated  investment  company under Subchapter M of the Internal
               Revenue Code of 1986, as amended;

          o    For any period  during  which the New York Stock  Exchange or any
               other  market  in  which  the  securities  owned  by the Fund are
               principally  traded is closed,  other than customary  weekend and
               holiday  closings,  or during  which  trading  in such  market is
               restricted;

          o    For any period  during which an  emergency  exists as a result of
               which  disposal  by the  Fund of  securities  owned  by it is not
               reasonably  practicable,  or  during  which it is not  reasonably
               practicable for the Fund fairly to determine the value of its net
               assets; or

          o    For such other periods as the  Commission may by order permit for
               the protection of securityholders of the Fund.

                             DIRECTORS AND OFFICERS

     A listing of the  directors  and  officers  of the Fund and their  business
experience for the past five years follows.  An asterisk (*) indicates directors
who are  "interested  persons" of the Fund (as defined by the 1940 Act).  Unless
otherwise  noted,  the address of each  director and officer is 410 Park Avenue,
New York, New York 10022.

<TABLE>
<CAPTION>
        Name, Age and        Position(s) Held
           Address              with Fund           Principal Occupation(s) During the Past 5 Years
     ----------------------  ----------------   -------------------------------------------------------
     <S>                     <C>                <C>
     Ronald S. Altbach (54)  Director           Chairman, Paul Sebastian,  Inc. (1994-present) (Perfume
     1540 West Park Avenue                      distributor); President, Olcott Corporation (1992-1994)
     Ocean, New Jersey 07712                    (Perfume distributor).


     *Richard E. Stierwalt   President and      President,   Chief  Executive   Officer  and  Director,
     (46)                    Chairman of the    Orbitex Financial  Services Group, Inc.  (1998-present)
                             Board              (Investment management);  Consultant, Bisys Management,
                                                Inc. (1996-1998) (Mutual fund distributor); Chairman of
                                                the  Board  and  Chief   Executive   Officer,   Concord
                                                Financial   Group   (1987-1996)    (Administrator   and
                                                distributor of mutual funds).


     Stephen J. Hamrick (48) Director           Chief Executive  Officer,  Carey Financial  Corporation
     Carey Financial Corp.                      (1995-present)    (Broker-dealer);    Chief   Executive
     50 Rockefeller Plaza                       Officer,  Wall Street  Investors  Services  (1994-1995)
     New York, New York 10020                   (Retail   brokerage   firm);   Senior  Vice  President,
                                                PaineWebber, Inc. (1988-1994) (Investment Services).


     Leigh Wilson (51)       Director           Chairman & CEO, New Century Care,  Inc.  (1989-present)
     53 Sylvan Road North                       (Merchant bank);  Principal,  New Century Living,  Inc.
     Westport, Connecticut                      (1995-present);  Director,  Chimney  Rock  Vineyard and
     06880                                      Chimney Rock Winery; President and Director, Key Mutual
                                                Funds (1989-present).


     Keith Kemp (39)         Vice President     Chief  Operations  Officer,  Orbitex  Management,  Inc.
                             and Assistant      (February   1999  -  present)   (Investment   Adviser);
                             Treasurer          Vice-President,  Fund  Accounting  and  Administration,
                                                Bank  of  New  York  (February  1998 -  February  1999)
                                                (Bank); Senior Manager, Forum Financial Group (November
                                                1996 -  February  1998)  (Mutual  Fund  Administrator);
                                                Business Unit Controller,  First Data Investor Services
                                                Group  (March  1995  -  November   1996)  (Mutual  Fund
                                                Administrator).


     M. Fyzul Khan (29)      Vice President     Legal Counsel,  Orbitex Financial  Services Group, Inc.
                             and Secretary      (1998-present); Attorney, CIBC Oppenheimer (1997-1998).


     Kevin Meehan (38)       Vice President     Chief Operations  Officer,  Orbitex Financial  Services
                             and Assistant      Group, Inc. (1998-present);  Manager, Investor Services
                             Secretary          Consulting, KPMG (1995-1998).


     Vali Nasr (46)          Vice President     Chief  Financial  Officer,  Orbitex  Management,   Inc.
                             and Treasurer      (1999-present);   Chief  Financial  Officer  and  Chief
                                                Operating   Officer,    Investment   Advisory   Network
                                                (1998-1999)  (Software   developer);   Chief  Financial
                                                Officer    and   Chief    Operations    Officer,    PMC
                                                International,  Inc.  (1992-1998)  (Investment adviser,
                                                broker-dealer, and software developer).
</TABLE>


                                                 8
<PAGE>


<TABLE>
<CAPTION>
        Name, Age and        Position(s) Held
           Address              with Fund           Principal Occupation(s) During the Past 5 Years
     ----------------------  ----------------   -------------------------------------------------------
     <S>                     <C>                <C>

     Catherine McCabe (33)   Assistant Vice     Compliance  Officer,  Orbitex  Management,  Inc. (March
                             President and      2000-present);  Compliance  Analyst,  Mutual of America
                             Assistant          Life  Insurance  Company  (February  1996- March 2000);
                             Secretary          Sales Assistant,  Smith Barney (June 1993-January 1996)
                                                (Broker-dealer).


     Michael Wagner (49)     Assistant          Senior Vice  President,  American Data  Services,  Inc.
     150 Motor Parkway       Treasurer          (1987-present) (Mutual Fund Administrator).
     Hauppauge, New York
     11788-0132
</TABLE>



     The Fund pays each Director of the Fund who is not an interested  person of
the Fund its  allocable  share of an aggregate per meeting fee of $2,500 for the
Fund and any other closed-end fund advised by Orbitex.


     The Fund also  reimburses  each such Director for travel and other expenses
incurred in attending meetings of the Board.

     The  Directors  serve on the  Board  for terms of  indefinite  duration.  A
Director's position in that capacity will terminate if such Director is removed,
resigns or is subject to various disabling events such as death or incapacity.

     The Board of Directors  has  approved a Code of Ethics (the  "Code")  under
Rule 17j-1 of the 1940 Act that covers the Fund and Orbitex.  The Code restricts
the personal investing  activities of personnel subject to the Code, but permits
them to invest in securities, including securities that may be purchased or held
by the Fund, if certain  procedures are followed.  Among other things,  the Code
provides for trading "blackout periods" which prohibit trading by such personnel
within seven calendar days before or after trading by the Fund in the same or an
equivalent  security.  The Code can be reviewed  and copied at the  Commission's
Public  Reference Room in Washington,  D.C.  Information on the operation of the
Public   Reference   Room  may  be  obtained  by  calling  the   Commission   at
1-202-942-8090.  The Code also is available on the Commission's Internet site at
http://www.sec.gov.  A copy of the Code  also may be  obtained,  after  paying a
duplicating fee, by electronic request at [email protected],  or by writing the
Commission's Public Reference Section, Washington, D.C. 20549-0102.

                     INVESTMENT ADVISORY AND OTHER SERVICES

     Orbitex  is  authorized  in its  discretion  to  engage  in  the  following
activities: (i) develop a continuing program for the management of the assets of
the Fund;  (ii) buy,  sell,  exchange,  convert,  lend,  or  otherwise  trade in
portfolio  securities  and other  assets;  (iii) place orders and  negotiate the
commissions  for the execution of  transactions  in  securities  with or through
broker-dealers,  underwriters,  or  issuers;  (iv)  prepare  and  supervise  the
preparation of shareholder reports and other shareholder communications; and (v)
obtain and evaluate  business and financial  information in connection  with the
exercise of its duties.

     Subject to  policies  established  by the Board of  Directors  of the Fund,
which has  overall  responsibility  for the  business  and  affairs of the Fund,
Orbitex  manages the  operations of the Fund. In addition to providing  advisory
services,  Orbitex  furnishes the Fund with office space and certain  facilities
and personnel required for conducting the business of the Fund.

     Orbitex is located at 410 Park Avenue, New York, New York 10022, and serves
as the  adviser  pursuant  to an  Investment  Advisory  Agreement  that has been
approved  by the Board,  including  a  majority  of the  independent  Directors.
Orbitex is a wholly-owned  subsidiary of Orbitex Financial Services Group, Inc.,
a New  York  holding  company.  The  initial  term  of the  Investment  Advisory
Agreement is two years.  The  Investment  Advisory  Agreement  will  continue in
effect from year to year if  approved at least


                                       9
<PAGE>


annually  by a vote of a majority  of the  Directors  who are not parties to the
Investment  Advisory  Agreement or interested persons of any such parties and by
vote of a  majority  of the Board  cast in person  at a meeting  called  for the
purpose  of  voting  on  such  renewal,  or by the  vote  of a  majority  of the
outstanding  shares of the Fund. The portfolio manager of the Fund is supervised
by John W. Davidson,  CFA,  Director,  President and Chief Investment Officer of
Orbitex.

     The Fund will pay to Orbitex a management fee at an annual rate of 1.75% of
the Fund's  average  daily net  assets.  The  management  fee is higher than the
advisory fees paid by most U.S. investment companies.

                                     EXPERTS

     PricewaterhouseCoopers  LLP, 160 Federal Street,  Boston, MA 02110, acts as
independent  accountants for the Fund and in such capacity will audit the Fund's
annual financial statements and financial highlights.


                          CUSTODIAN, TRANSFER AGENT AND
                            DIVIDEND DISBURSING AGENT

     Circle  Trust  Company,   Metro  Center,   One  Station  Place,   Stamford,
Connecticut 06902, serves as custodian to the Fund. Circle Trust is an affiliate
of Orbitex. Circle Trust's responsibilities include safeguarding and controlling
the Fund's cash and  securities,  handling the receipt and delivery of portfolio
securities,  and  collecting  interest and dividends on the Fund's  investments.
Circle  Trust  provides  a full range of  custody,  management,  accounting  and
administrative  services to  institutional  investors  worldwide.  American Data
Services,  Inc., The Hauppauge  Corporate Center, 150 Motor Parkway,  Hauppauge,
New York 11788, is an affiliate of Orbitex and serves as Fund  accounting  agent
and is responsible for the  determination of the net asset value of the Fund. It
also maintains,  under the general supervision of Orbitex, the Fund's accounting
records.  American Data  Services,  Inc. acts as the transfer agent and dividend
disbursing  agent of the Fund,  and  performs,  at cost,  certain  recordkeeping
functions for the Fund. In other words,  American Data Services,  Inc. maintains
the records of shareholder  accounts and furnishes  dividend paying,  redemption
and related services.


                              BROKERAGE COMMISSIONS

     Subject to the general  supervision  of the Board of Directors,  Orbitex is
responsible  for  making  decisions  with  respect to the  purchase  and sale of
portfolio  securities on behalf of the Fund. Orbitex also is responsible for the
implementation of those decisions,  including the selection of broker-dealers to
effect  portfolio  transactions,   the  negotiation  of  commissions,   and  the
allocation of principal business and portfolio brokerage.

     In purchasing and selling the Fund's portfolio securities,  it is Orbitex's
policy  to  obtain  quality  execution  at the  most  favorable  prices  through
responsible  broker-dealers  and,  in  the  case  of  agency  transactions,   at
competitive  commission  rates where such rates are negotiable.  However,  under
certain conditions,  the Fund may pay higher brokerage commissions in return for
brokerage  and research  services.  In selecting  broker-dealers  to execute the
Fund's  portfolio  transactions,  consideration  is given to such factors as the
price of the security,  the rate of the  commission,  the size and difficulty of
the order, the reliability,  integrity,  financial condition,  general execution
and operational  capabilities of competing brokers and dealers,  their expertise
in particular  markets and the  brokerage and research  services they provide to
Orbitex  or the  Fund.  It is not the  policy  of  Orbitex  to seek  the  lowest
available  commission rate where it is believed that a broker or dealer charging
a higher commission rate would offer greater reliability or provide better price
execution.


                                       10
<PAGE>


     Transactions   on  stock   exchanges   involve  the  payment  of  brokerage
commissions.  In  transactions  on stock  exchanges in the United States,  these
commissions are negotiated.  Traditionally,  commission rates have generally not
been  negotiated on stock markets  outside the United  States.  In recent years,
however, an increasing number of overseas stock markets have adopted a system of
negotiated  rates,  although  a number of markets  continue  to be subject to an
established  schedule of minimum  commission  rates.  It is expected that equity
securities  will  ordinarily  be  purchased  in  the  primary  markets,  whether
over-the-counter  or listed,  and that listed securities may be purchased in the
over-the-counter market if such market is deemed the primary market. In the case
of  securities  traded on the  over-the-counter  markets,  there is generally no
stated commission,  but the price usually includes an undisclosed  commission or
markup.  In  underwritten  offerings,  the price  includes  a  disclosed,  fixed
commission or discount.

     For fixed  income  securities,  it is  expected  that  purchases  and sales
ordinarily will be transacted with the issuer, the issuer's underwriter, or with
a primary  market maker  acting as  principal on a net basis,  with no brokerage
commission  being  paid  by the  Fund.  However,  the  price  of the  securities
generally includes compensation which is not disclosed separately.  Transactions
placed  through  dealers who are serving as primary  market  makers  reflect the
spread between the bid and asked prices.

     With  respect to equity and fixed  income  securities,  Orbitex  may effect
principal  transactions  on  behalf  of the Fund  with a broker  or  dealer  who
furnishes  brokerage  and/or  research  services,  designate  any such broker or
dealer  to  receive  selling  concessions,  discounts  or  other  allowances  or
otherwise deal with any such broker or dealer in connection with the acquisition
of  securities in  underwritings.  The prices the Fund pays to  underwriters  of
newly-issued  securities  usually include a concession paid by the issuer to the
underwriter.  Orbitex may receive research services in connection with brokerage
transactions, including designations in fixed price offerings.

     Orbitex receives a wide range of research services from brokers and dealers
covering investment opportunities throughout the world, including information on
the  economies,   industries,   groups  of  securities,   individual  companies,
statistics,  political  developments,   technical  market  action,  pricing  and
appraisal  services,  and  analyses  of all the  countries  in  which  a  Fund's
portfolio is likely to be invested.  Orbitex cannot readily determine the extent
to which  commissions  charged by brokers  reflect  the value of their  research
services,  but brokers  occasionally suggest a level of business they would like
to receive in return for the  brokerage and research  services they provide.  To
the extent that research services of value are provided by brokers,  Orbitex may
be relieved of expenses which it might otherwise  bear. In some cases,  research
services  are  generated  by third  parties  but are  provided  to Orbitex by or
through brokers.

     Certain  broker-dealers  which  provide  quality  execution  services  also
furnish research services to Orbitex.  Orbitex has adopted brokerage  allocation
polices  embodying the concepts of Section 28(e) of the Securities  Exchange Act
of 1934,  which  permits an  investment  adviser  to cause its  clients to pay a
broker which furnishes  brokerage or research  services a higher commission than
that which might be charged by another  broker which does not furnish  brokerage
or research services,  or which furnishes  brokerage or research services deemed
to be of lesser value,  if such  commission is deemed  reasonable in relation to
the brokerage and research services  provided by the broker,  viewed in terms of
either  that  particular  transaction  or the  overall  responsibilities  of the
adviser  with  respect  to the  accounts  as to  which it  exercises  investment
discretion. Accordingly, Orbitex may assess the reasonableness of commissions in
light of the total brokerage and research  services  provided by each particular
broker.  Orbitex may also consider sales of the Fund's shares as a factor in the
selection of broker-dealers.


                                       11
<PAGE>


                             ADDITIONAL INFORMATION

         Unless  otherwise  required by the 1940 Act,  ordinarily it will not be
necessary  for the Fund to hold annual  meetings of  stockholders.  As a result,
Fund  stockholders  may not consider  each year the election of Directors or the
appointment  of  auditors.  However,  the  holders of at least a majority of the
shares  outstanding  and entitled to vote may require the Fund to hold a special
meeting of  stockholders  for any purpose,  including to remove a Director  from
office.  Fund  stockholders  may remove a Director by the affirmative  vote of a
majority of the Fund's  outstanding  voting shares. In addition,  the Board will
call a meeting of stockholders for the purpose of electing  Directors if, at any
time,  less than a majority  of the  Directors  then  holding  office  have been
elected by stockholders.


                                       12
<PAGE>


            FINANCIAL STATEMENT AND REPORT OF INDEPENDENT ACCOUNTANTS

                      ORBITEX LIFE SCIENCES & BIOTECHNOLOGY
                                   FUND, INC.

                       STATEMENT OF ASSETS AND LIABILITIES
                                  JULY 14, 2000

                                     ASSETS


Cash ..............................................................    $100,000
Prepaid expenses ..................................................      95,775
                                                                       --------

Total assets ......................................................     195,775
                                                                       --------


                                  LIABILITIES


Accrued expenses payable ..........................................      95,775


Common Shares, $0.01 par value; 100,000,000 shares authorized,
   4,000 shares issued and outstanding ............................          40

Paid-in capital ...................................................      99,960
                                                                       --------

Net Assets ........................................................    $100,000
                                                                       --------


Net Asset Value Per Share .........................................    $     25
                                                                       --------
Maximum Sales Charge ..............................................           4%
Offering Price Per Share ..........................................    $     26
                                                                       --------

     The accompanying notes are an integral part of the financial statement



                                       13
<PAGE>



NOTES TO FINANCIAL STATEMENT

NOTE 1.  ORGANIZATION

     Orbitex  Life  Sciences  &  Biotechnology   Fund,  Inc.  (the  "Fund")  was
incorporated  in  Maryland  on April 6,  2000 as a  non-diversified,  closed-end
management  investment company.  The Fund has had no operations other than those
related  to  organizational  matters  and  the  sale  and  issuance  to  Orbitex
Management, Inc. (the "Manager") of 4,000 shares of common stock for $100,000.

     Included in prepaid  expenses are the offering costs incurred in connection
with the initial  offering of the Fund's  shares.  The prepaid  expenses will be
charged  directly  to paid-in  capital  upon the sale of the  shares.  The costs
incurred  in  connection  with the  organization  of the  Fund of  approximately
$50,000 will be paid directly by the Manager.

     The Fund's  financial  statements are prepared in accordance with generally
accepted  accounting  principles which require the use of management  estimates.
Actual results may differ from those estimates.

NOTE 2.  TRANSACTIONS WITH AFFILIATES

     The  Management  Agreement  provides  that  the Fund  will pay the  Manager
monthly a management fee at the annual rate of 1.75% of the Fund's average daily
net assets. The Fund will pay Orbitex Funds  Distributor,  Inc., an affiliate of
the Manager,  a one-time  placement  fee of .50% of the net  proceeds  from Fund
shares sold.  The Fund has entered into an  administrative,  transfer  agent and
service,  and fund  accounting  service  agreement  with American Data Services,
Inc.,  an  affiliate of the Manager,  and into a custody  agreement  with Circle
Trust Company, an affiliate of the Manager.

NOTE 3.  INCOME TAXES

     The Fund intends to meet the  requirements of the Internal  Revenue Code of
1986  applicable  to  regulated  investment  companies  and as such  will not be
subject to federal income taxes.



                                       14
<PAGE>



                        REPORT OF INDEPENDENT ACCOUNTANTS


To the Directors and Shareholder of
Orbitex Life Sciences & Biotechnology Fund, Inc.

In our opinion,  the accompanying  statement of assets and liabilities  presents
fairly,  in all material  respects,  the financial  position of the Orbitex Life
Sciences & Biotechnology Fund, Inc. (the "Fund") at July 14, 2000, in conformity
with  accounting  principles  generally  accepted  in the  United  States.  This
financial  statement  is  the  responsibility  of  the  Fund's  management;  our
responsibility is to express an opinion on this financial statement based on our
audit.  We conducted our audit of this  financial  statement in accordance  with
auditing standards  generally accepted in the United States,  which require that
we plan and perform the audit to obtain  reasonable  assurance about whether the
financial  statement  is  free  of  material  misstatement.  An  audit  includes
examining,  on a test basis,  evidence supporting the amounts and disclosures in
the  financial   statement,   assessing  the  accounting   principles  used  and
significant  estimates made by management,  and evaluating the overall financial
statement  presentation.  We believe that our audit provides a reasonable  basis
for the opinion expressed above.


PricewaterhouseCoopers LLP
Boston, Massachusetts
July 20, 2000



                                       15
<PAGE>


                                    FORM N-2
                ORBITEX LIFE SCIENCES & BIOTECHNOLOGY FUND, INC.
                            PART C. OTHER INFORMATION

Item 24.  Financial Statements and Exhibits


          1.   Financial Statements:
               Part A: Financial Highlights (not applicable).
               Part B:  Statement  of  Assets  and  Liabilities  and  Report  of
               Independent Accountants

          2.   Exhibits:

          a.   Charter of  Registrant  is  incorporated  by reference to Exhibit
               2(a) to the Fund's Registration Statement on Form N-2.

          b.   Bylaws of  Registrant  are  incorporated  by reference to Exhibit
               2(b) to the Fund's Registration Statement on Form N-2.

          c.   Not Applicable.

          d.   Not Applicable.

          e.   Not Applicable.

          f.   Not Applicable.

          g.   Investment  Advisory  Agreement  between  Registrant  and Orbitex
               Management, Inc.

          h.   Distribution  Agreement between Registrant and Funds Distributor,
               Inc.

          i.   Not Applicable.

          j.   Custody Agreement.

          k.   Not Applicable.

          l.   Opinion and Consent of Counsel.

          m.   Not Applicable.

          n.   Consent of Independent Auditors.

          o.   Not Applicable.

          p.   Not Applicable.

          q.   Not Applicable.

          r.   Code of Ethics.

Item 25.  Marketing Arrangements:  Not Applicable.


Item 26.  Other Expenses of Issuance and Distribution:

                  Registration fees                                  $ 56,000
                  Legal fees                                         $ 75,000
                  Accounting fees                                    $  5,000
                  Miscellaneous (mailing, etc.)                      $ 24,000
                  Total............................................. $175,000



                                       C-1
<PAGE>



Item 27.  Persons Controlled by or Under Common Control with Registrant:  None.

Item 28.  Number of Holders of Securities as of September 15, 2000:

                  Title of Class                         Number of Recordholders
                  Common Stock                                        1


Item 29.  Indemnification:

                  Reference is made to the provisions of Article  SEVENTH of the
                  Registrant's  Charter  and  Article  VII of  the  Registrant's
                  Bylaws,   each  filed  as  an  exhibit  to  this  Registration
                  Statement.  Insofar as indemnification for liabilities arising
                  under  the   Securities  Act  of  1933  may  be  permitted  to
                  directors,  officers and controlling persons of the Registrant
                  pursuant  to  the  foregoing  provisions,  or  otherwise,  the
                  Registrant  has been  advised by the  Securities  and Exchange
                  Commission that such  indemnification is against public policy
                  as expressed in the Act and is, therefore,  unenforceable.  In
                  the  event  that a  claim  for  indemnification  against  such
                  liabilities  (other  than the  payment  by the  Registrant  of
                  expenses   incurred  or  paid  by  a   director,   officer  or
                  controlling person of the Registrant in the successful defense
                  of any  action,  suit  or  proceeding)  is  asserted  by  such
                  director, officer or controlling person in connection with the
                  securities being  registered,  the Registrant will,  unless in
                  the  opinion of its  counsel  the  matter has been  settled by
                  controlling  precedent,  submit  to  a  court  of  appropriate
                  jurisdiction the question whether such  indemnification  by it
                  is against  public  policy as expressed in the Act and will be
                  governed by the final adjudication of such issue.

Item 30.  Business and Other Connections of Investment Adviser:

                  Certain   information   pertaining   to  business   and  other
                  connections of the Registrant's  Adviser,  Orbitex Management,
                  Inc.,  is  hereby  incorporated  herein  by  reference  to the
                  section of the Prospectus  captioned  "Management of the Fund"
                  and to the section of the Statement of Additional  Information
                  captioned   "Investment  Advisory  and  Other  Services."  The
                  information  required  by this  Item 30 with  respect  to each
                  director,  officer or partner of Orbitex  Management,  Inc. is
                  incorporated  by reference to Form ADV with the Securities and
                  Exchange Commission pursuant to the Investment Advisers Act of
                  1940, as amended (File No. 801-52312).

Item 31.  Location of Accounts and Records:

                  Custodian:    Circle Trust Company
                                Metro Center
                                One Station Place
                                Stamford, Connecticut 06902

                                      and

                                Orbitex Life Sciences & Biotechnology Fund, Inc.
                                c/o Orbitex Management, Inc.
                                410 Park Avenue, 18th Floor
                                New York, New York 10022

Item 32.  Management Services:  Not Applicable.

Item 33.  Undertakings:


                                       C-2
<PAGE>


     I.   The Registrant  undertakes to suspend the offering of shares until the
          prospectus  is  amended if  subsequent  to the  effective  date of its
          registration  statement,  the net asset value  declines  more than ten
          percent  from  its net  asset  value as of the  effective  date of the
          registration statement.

     II.  The Registrant undertakes that:

          (a)  For purposes of  determining  any liability  under the Securities
               Act, the information omitted from the form of prospectus filed as
               part of this  registration  statement in reliance  upon Rule 430A
               and  contained in a form of  prospectus  filed by the  Registrant
               pursuant to Rule  424(b)(1) or (4) or 497(h) under the Securities
               Act shall be deemed to be part of this registration  statement as
               of the time it was declared effective.

          (b)  For the purpose of determining any liability under the Securities
               Act,  each  post-effective  amendment  that  contains  a form  of
               prospectus  shall be  deemed to be a new  registration  statement
               relating to the securities  offered therein,  and the offering of
               such  securities  at that time shall be deemed to be the  initial
               bona fide offering thereof.

     III. The  Registrant  undertakes to send by first class mail or other means
          designed to ensure equally prompt delivery within two business days of
          receipt of a written or oral request,  the  Registrant's  Statement of
          Additional Information.


                                       C-3
<PAGE>


                                   SIGNATURES

     Pursuant  to  the  requirements  of the  Securities  Act of  1933  and  the
Investment Company Act of 1940, the Registrant has duly caused this Amendment to
Registration  Statement to be signed on its behalf by the undersigned,  its duly
authorized  representative,  in the City of New York,  State of New York, on the
29th day of September, 2000.

                                           ORBITEX LIFE SCIENCES & BIOTECHNOLOGY
                                                FUND, INC.


                                           By: /s/ Richard E. Stierwalt
                                              ----------------------------------
                                              Richard E. Stierwalt
                                              Chairman of the Board


     Pursuant to the  requirements of the Securities Act of 1933, this Amendment
to Registration Statement has been signed below by the following persons, in the
capacities indicated, on September 29, 2000.

       Name                                 Title


/s/  Richard E. Stierwalt           Chairman of the Board
--------------------------------    (Principal executive officer and Director)
     (Richard E. Stierwalt)


/s/  Vali Nasr                      Treasurer
--------------------------------    (Principal financial and accounting officer)
     (Vali Nasr)


/s/  Stephen J. Hambrick            Director
--------------------------------
     (Stephen J. Hambrick)


/s/  Ronald S. Altbach              Director
--------------------------------
     (Ronald S. Altbach)


/s/  Leigh Wilson                   Director
--------------------------------
     (Leigh Wilson)



                                       C-4


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