DISCOVERY PARTNERS INTERNATIONAL INC
10-Q, 2000-11-14
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549


                                   ----------


                                    FORM 10-Q



             QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


                FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2000






                        Commission File Number 000-31141


                     DISCOVERY PARTNERS INTERNATIONAL, INC.


State of Incorporation:  Delaware             I.R.S. Employer ID #:  33-0655706


Address: 9640 Towne Centre Drive                   Telephone #:  (858) 455-8600
         San Diego, California  92121






Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days   Yes [X]  No[ ]


As of October 31, 2000 a total of 23,848,751 shares of the Registrant's Common
Stock, $0.001 par value, were issued and outstanding.

<PAGE>   2

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                                    FORM 10-Q

                                TABLE OF CONTENTS

<TABLE>
<S>     <C>                                                                           <C>
                                                                                      PAGE
                                                                                      ----
PART I.  FINANCIAL INFORMATION

Item 1.  Financial Statements:

         Condensed Consolidated Balance Sheets at September 30, 2000 and
            December 31, 1999.......................................................   3

         Condensed Consolidated Statements of Operations for the Three Months
            and Nine Months Ended September 30, 2000 and 1999.......................   4

         Condensed Consolidated Statements of Cash Flows for the Nine Months
            Ended September 30, 2000 and 1999.......................................   5

         Notes to Consolidated Financial Statements.................................   6

Item 2.  Management's Discussion and Analysis of Financial Condition and Results
         of Operations..............................................................   8

Item 3.  Quantitative and Qualitative Disclosures About Market Risk.................  10

PART II. OTHER INFORMATION

Item 1.  Legal Proceedings..........................................................  19

Item 2.  Changes in Securities and Use of Proceeds..................................  19

Item 3.  Defaults Upon Senior Securities............................................  19

Item 4.  Submission of Matters to a Vote of Security Holders........................  20

Item 5.  Other Information..........................................................  20

Item 6.  Exhibits and Reports on Form 8-K...........................................  20
</TABLE>


                                       2
<PAGE>   3

                     DISCOVERY PARTNERS INTERNATIONAL, INC.

                                     PART I
                              FINANCIAL INFORMATION

ITEM 1.  FINANCIAL STATEMENTS

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                     Condensed Consolidated Balance Sheets

<TABLE>
<CAPTION>
                                                                            SEPTEMBER 30, 2000   DECEMBER 31, 1999
                                                                            ------------------   -----------------
                                                                               (UNAUDITED)
<S>                                                                         <C>                  <C>
ASSETS

Current assets:
    Cash and cash equivalents                                                 $  97,206,578       $   2,884,639
    Accounts receivable                                                           8,394,350           2,785,618
    Inventories                                                                   9,717,993           1,517,297
    Prepaid and other current assets                                              2,228,134             201,284
                                                                              -------------       -------------
      Total current assets                                                      117,547,055           7,388,838

Property and equipment, net                                                       8,785,705           4,655,227

Restricted cash and cash equivalents and other assets                             3,040,853           2,264,200

Patent and license rights, net                                                    3,227,475           1,137,625

Goodwill, net                                                                    45,391,309           6,205,830
                                                                              -------------       -------------
      Total assets                                                            $ 177,992,397       $  21,651,720
                                                                              =============       =============

LIABILITIES REDEEMABLE PREFERRED STOCK AND
STOCKHOLDERS' EQUITY (DEFICIT)

Current liabilities:
    Accounts payable & accrued expenses                                       $   5,585,821       $   2,348,226
    Deferred business acquisition payment                                                 -           1,721,775
    Current portion of obligations under capital leases, equipment
      notes payable, line of credit and promissory notes                            761,360           1,184,921
    Deferred revenue                                                              4,182,386           1,935,249
    Notes payable to stockholders                                                         -           3,861,920
                                                                              -------------       -------------
      Total current liabilities                                                  10,529,567          11,052,091

Obligations under capital leases, equipment notes payable,
    and promissory notes less current portion                                       749,162           1,910,177
Deferred rent                                                                        62,363              51,906

Minority interest in Structural Proteomics                                          678,588                   -

Redeemable convertible preferred stock, $.001 par value,
    0 shares authorized as of September 30, 2000; 0 and 6,562,278 issued
    and outstanding at September 30, 2000 and December 31, 1999,
    respectively                                                                          -          27,906,717

Stockholders' equity (deficit):
    Common stock, $.001 par value, 99,000,000 shares authorized,
      23,844,354 and 1,611,763 issued and outstanding at September 30,
      2000 and December 31, 1999, respectively                                       23,844               1,612
    Preferred stock, $.001 par value, 1,000,000 shares authorized,
      0 shares issued and outstanding at September 30, 2000 and
      December 31, 1999                                                                   -                   -
    Additional paid-in capital                                                  200,016,108           1,399,376
    Deferred compensation                                                        (2,380,832)           (642,282)
    Note receivable from stockholder                                               (240,000)           (240,000)
    Accumulated other comprehensive loss                                           (137,909)            (55,448)
    Accumulated deficit                                                         (31,308,494)        (19,732,429)
                                                                              -------------       -------------
      Total stockholders' equity (deficit)                                      165,972,717         (19,269,171)
                                                                              -------------       -------------
      Total liabilities and stockholders' equity                              $ 177,992,397       $  21,651,720
                                                                              =============       =============
</TABLE>

See accompanying notes.



                                       3
<PAGE>   4

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                        3 MONTHS ENDED SEPTEMBER 30,  9 MONTHS ENDED SEPTEMBER 30,
                                                                        ---------------------------   ---------------------------
                                                                            2000           1999           2000           1999
                                                                        ------------   ------------   ------------   ------------
<S>                                                                     <C>            <C>            <C>            <C>
Revenues                                                                $ 10,159,438   $  3,852,887   $ 24,860,364   $ 10,112,233

Cost of revenues (exclusive of $5,292, $2,909, $13,105 and
     $4,116 for the three months ended September 30, 2000 and 1999,
     and for the nine months ended September 30, 2000 and 1999,
     respectively, of stock-based compensation)                            5,034,624      2,402,660     12,811,364      6,330,370
                                                                         ------------   ------------   ------------   ------------
     Gross margin                                                          5,124,814      1,450,227     12,049,000      3,781,863
                                                                         ------------   ------------   ------------   ------------
Cost and expenses:

    Research and development (exclusive of $159,661, $18,303,
      $386,446 and $32,754 for the three months ended September 30,
      2000 and 1999, and for the nine months ended September 30,
      2000 and 1999, respectively, of stock-based compensation)            2,821,483        774,937      5,317,105      2,487,927

    Selling, general & administrative (exclusive of $211,652, $58,389,
      $586,572 and $179,776 for the three months ended September 30,
      2000 and 1999, and for the nine months ended September 30,
      2000 and 1999, respectively, of stock-based compensation)            2,318,800      1,150,270      6,009,243      3,205,215

    Amortization of stock-based compensation                                 376,605         79,601        986,123        216,646
    Amortization of goodwill                                               1,190,410              -      2,190,877              -
    Write-off of in-process research and development                               -              -      9,000,000              -
                                                                        ------------   ------------   ------------   ------------
      Total operating expenses                                             6,707,298      2,004,808     23,503,348      5,909,788
                                                                        ------------   ------------   ------------   ------------
Loss from operations                                                      (1,582,484)      (554,581)   (11,454,348)    (2,127,925)

Interest income (expense)                                                  1,000,531         48,467       (299,397)       190,878
Foreign currency gains (losses)                                              (86,666)        18,899        107,030        (74,590)

Minority interest in Structural Proteomics                                    38,047              -         70,650              -
                                                                        ------------   ------------   ------------   ------------
Net loss                                                                $   (630,572)  $   (487,215)  $(11,576,065)  $ (2,011,637)
                                                                        ============   ============   ============   ============
Historical net loss per share, basic and diluted                        $      (0.03)  $      (0.42)  $      (1.19)  $      (1.84)
                                                                        ============   ============   ============   ============
Shares used in calculating historical net loss per share,
    basic and diluted                                                     18,731,561       1,167,079      9,692,420      1,094,939
                                                                        ============    ============   ============   ============
Pro forma net loss per share, basic and diluted                         $      (0.03)   $      (0.06)  $      (0.75)  $      (0.26)
                                                                        ============    ============   ============   ============
Shares used in calculating pro forma net loss per share,
    basic and diluted                                                     21,598,203       7,770,653     15,525,048      7,698,513
                                                                        ============    ============   ============   ============
</TABLE>

See accompanying notes



                                       4
<PAGE>   5

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                 Condensed Consolidated Statement of Cash Flows
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                     NINE MONTHS ENDED SEPTEMBER 30,
                                                                    ---------------------------------
                                                                        2000                 1999
                                                                    -------------       -------------
<S>                                                                 <C>                 <C>
OPERATING ACTIVITIES
Net loss                                                            $ (11,576,065)      $  (2,011,637)
Adjustments to reconcile net loss to cash used in
    operating activities:
  Depreciation and amortization                                         2,145,843             557,863
  Amortization of purchased intangibles                                   305,000                   -
  Amortization of goodwill                                              2,035,734                   -
  Amortization of deferred compensation                                   986,123             216,646
  Noncash interest expense for warrants issued                          1,243,847                   -
  Write-off of In-Process R&D                                           9,000,000                   -
  Change in operating assets and liabilities:
    Accounts receivable                                                (3,804,225)           (492,249)
    Inventories                                                        (1,346,547)            274,270
    Other current assets                                               (1,916,017)           (363,222)
    Accounts payable and accrued expenses                               1,260,841            (923,319)
    Deferred revenue                                                    1,319,360          (1,120,216)
    Deferred rent                                                          10,455             (31,748)
    Restricted cash                                                        98,000          (1,000,000)
                                                                    -------------       -------------
Net cash used in operating activities                                    (237,651)         (4,893,612)

INVESTING ACTIVITIES
Purchases of property and equipment                                    (2,619,591)         (1,092,696)
Deposits and other assets                                                (760,842)            181,024
Additional cash consideration for acquisition of
  Discovery Technologies                                               (1,721,775)         (1,958,863)
Purchase of Axys Advanced Technologies                                   (235,575)                  -
                                                                    -------------       -------------
Net cash used in investing activities                                  (5,337,783)         (2,870,535)

FINANCING ACTIVITIES
Proceeds from equipment lease line                                        747,150                   -
Principal payments on capital leases, equipment notes payable,
  line of credit, and promissory notes                                 (2,205,626)           (172,887)
Issuance of preferred stock, net of issuance costs                      5,004,801                   -
Issuance of common stock, net of issuance costs                        94,809,478               5,433
Proceeds from convertible notes payable                                 2,000,000                   -
                                                                    -------------       -------------
Net cash provided by (used in) financing activities                   100,355,803            (167,454)
Effect of exchange rate changes                                          (458,429)                  -
                                                                    -------------       -------------
Net increase (decrease) in cash and cash equivalents                   94,321,940          (7,931,601)

Cash and cash equivalents at beginning of period                        2,884,639          10,714,889
                                                                    -------------       -------------
Cash and cash equivalents at end of period                          $  97,206,579       $   2,783,288

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION
Interest paid                                                       $     259,395       $      36,405

SUPPLEMENTAL SCHEDULE OF NONCASH INVESTING AND FINANCING ACTIVITIES
Conversion of convertible notes payable to
   preferred stock                                                  $   6,000,000       $           -
Issuance of common stock for promissory note                        $           -       $      68,000
Issuance of warrant to purchase preferred stock                     $   1,105,767       $           -
                                                                    =============       =============
</TABLE>

See accompanying notes.



                                       5
<PAGE>   6

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                   (UNAUDITED)
                               SEPTEMBER 30, 2000

1.      BASIS OF PRESENTATION

        The accompanying unaudited condensed consolidated financial statements
have been prepared in accordance with generally accepted accounting principles
for interim financial information and with the instructions to Form 10-Q and
Article 10 of Regulation S-X. Accordingly, they do not include all of the
information and footnotes required by generally accepted accounting principles
for complete financial statements. The condensed consolidated balance sheet as
of September 30, 2000, condensed consolidated statements of operations for the
three and nine months ended September 30, 2000, and the condensed consolidated
statements of cash flows for the nine months ended September 30, 2000 and 1999
are unaudited, but include all adjustments (consisting of normal recurring
adjustments) which the Company considers necessary for a fair presentation of
the financial position, results of operations and cash flows for the periods
presented. The results of operations for the three and nine months ended
September 30, 2000 shown herein are not necessarily indicative of the results
that may be expected for the year ending December 31, 2000. For more complete
financial information, these financial statements, and notes thereto, should be
read in conjunction with the audited consolidated financial statements for the
year ended December 31, 1999 included in the Company's Form S-1 registration
statement as declared effective on July 27, 2000 by the Securities and Exchange
Commission.

        The consolidated financial statements include all the accounts of the
Company and its wholly owned or majority owned subsidiaries, IRORI Europe, Ltd.,
Discovery Technologies, Ltd., ChemRx Advanced Technologies, Inc., and Structural
Proteomics, Inc. All intercompany accounts and transactions have been
eliminated.

2.      NET LOSS PER SHARE

        Basic and diluted net loss per common share are presented in conformity
with SFAS No. 128, Earnings per Share, and SAB 98, for all periods presented.
Under the provisions of SAB 98, common stock and redeemable convertible
preferred stock that has been issued or granted for nominal consideration prior
to the anticipated effective date of the initial public offering must be
included in the calculation of basic and diluted net loss per common share as if
these shares had been outstanding for all periods presented. To date, the
Company has not issued or granted shares for nominal consideration.

        In accordance with SFAS No. 128, basic and diluted net loss per share
has been computed using the weighted-average number of shares of common stock
outstanding during the period; less shares subject to repurchase. Pro forma
basic and diluted net loss per common share, as presented in the statements of
operations, has been computed for the three and nine month periods ended
September 30, 2000 and 1999 as described above, and also gives effect to the
conversion of preferred stock which automatically converted to common stock
immediately prior to the completion of the Company's initial public offering on
July 27, 2000 (using the "as if converted" method) from the original date of
issuance.

        The Company has excluded all convertible preferred stock, outstanding
stock options and warrants, and shares subject to repurchase from the
calculation of diluted net loss per common share because all such securities are
anti-dilutive for all applicable periods presented.

3.      ACQUISITION OF AXYS ADVANCED TECHNOLOGIES, INC.

        On April 28, 2000, the Company acquired Axys Advanced Technologies, Inc.
(AAT), a wholly owned subsidiary of Axys Pharmaceuticals, Inc. The acquisition
was accounted for as a purchase in accordance with the provisions of APB No. 16.
The Company and Axys will make certain income tax elections so that the total
cost of the acquisition will be allocated to the income tax basis of the assets
acquired. The Company has obtained a report from Houlihan Valuation Advisors, an
independent valuation firm and performed other procedures necessary to complete
the purchase price allocation.



                                       6
<PAGE>   7

        A summary of the AAT acquisition costs and allocation to the assets
acquired and liabilities assumed is as follows:

<TABLE>
<S>                                                            <C>
   Total acquisition costs:
      Cash paid at acquisition                                    $     50,000
      Issuance of promissory note                                      550,334
      Issuance of common stock, warrant and stock options           59,769,495
      Acquisition-related expenses                                     345,099
                                                                  ------------
                                                                  $ 60,714,928
                                                                  ============
   Allocated to assets and liabilities as follows:
      Tangible assets acquired                                    $ 12,252,068
      Assumed liabilities                                           (2,581,167)
      In-process research and development                            9,000,000
      Assembled workforce                                            1,344,067
      Below market value lease                                       1,221,105
      Goodwill                                                      39,478,855
                                                                  ------------
                                                                  $ 60,714,928
                                                                  ============
</TABLE>

        The goodwill will be amortized on a straight-line basis over a period of
ten years from the date of acquisition. The assembled workforce and below market
lease intangible assets will be amortized on a straight-line basis over a period
of three and four years, respectively, from the date of acquisition.

        The value of the in-process research and development was determined
based on a discounted cash flow analysis of projected future earnings for each
project. The revenue stream from each research and development project was
estimated based upon its stage of completion as of the acquisition date. The
discount rates used for the analysis were adjusted based on the stage of
completion to give effect to uncertainties in meeting the projected cash flows.
The discount rates used ranged from 20% to 40%.

        Assuming that the acquisition of AAT had occurred on the first day of
the Company's fiscal year ended December 31, 1999, pro forma condensed
consolidated financial information would be as follows:

<TABLE>
<CAPTION>
                                                   Nine months ended September 30,
                                                   -------------------------------
                                                      2000                  1999
                                                      ----                  ----
<S>                                           <C>                   <C>
   Revenues                                      $ 29,931,173          $ 20,592,733
   Net loss                                       (12,422,066)           (2,611,637)
   Net loss per share, basic and diluted         $      (0.85)         $      (0.31)
</TABLE>


        This pro forma information is not necessarily indicative of the actual
results that would have been achieved had AAT been acquired the first day of the
Company's fiscal year ended December 31, 1999, nor is it necessarily indicative
of future results.

4.      DEFERRED STOCK COMPENSATION

        In conjunction with the Company's initial public offering effective on
July 27, 2000, the Company reviewed its stock option grant exercise prices and
arrived at the estimated fair value for each option grant in 1999 and the first
nine months of 2000. With respect to the grant of stock options and sale of
restricted stock to employees during the year ended December 31, 1999 and the
nine months ended September 30, 2000, the Company has recorded deferred stock
compensation totaling approximately $3.7 million, representing the difference at
the date of grant between the exercise or purchase price and the estimated fair
value of the Company's common stock as estimated by the Company's management for
financial reporting purposes in accordance with APB No. 25. Deferred
compensation is included as a reduction of stockholders' equity and is being
amortized to expense on an accelerated basis in accordance with Financial
Accounting Standards Board Interpretation No. 28 over the vesting period of the
options and restricted stock. During the nine months ended September 30, 2000,
the Company recorded amortization of stock-based compensation expense of
approximately $1.0 million.



                                       7
<PAGE>   8

                     DISCOVERY PARTNERS INTERNATIONAL, INC.

                                     PART I
                        FINANCIAL INFORMATION (CONTINUED)



ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

THIS FORM 10-Q CONTAINS CERTAIN STATEMENTS THAT ARE NOT STRICTLY HISTORICAL AND
ARE "FORWARD-LOOKING" STATEMENTS WITHIN THE MEANING OF THE PRIVATE SECURITIES
LITIGATION REFORM ACT OF 1995 AND INVOLVE A HIGH DEGREE OF RISK AND UNCERTAINTY.
OUR ACTUAL RESULTS MAY DIFFER MATERIALLY FROM THOSE PROJECTED IN THE
FORWORD-LOOKING STATEMENTS DUE TO RISKS AND UNCERTAINTIES THAT EXIST IN OUR
OPERATIONS, DEVELOPMENT EFFORTS AND BUSINESS ENVIRONMENT, INCLUDING INTEGRATION
OF ACQUIRED BUSINESSES, THE TREND TOWARD CONSOLIDATION OF THE PHARMACEUTICAL
INDUSTRY, QUARTERLY SALES VARIABILITY, TECHNOLOGICAL ADVANCES BY COMPETITORS,
AND OTHER RISKS AND UNCERTAINTIES DESCRIBED IN THIS DOCUMENT AND OUR FORM S-1
REGISTRATION STATEMENT AS DECLARED EFFECTIVE ON JULY 27, 2000 BY THE SECURITIES
AND EXCHANGE COMMISSION.

                                    OVERVIEW

        We sell a broad range of products and services to pharmaceutical and
biotechnology companies to make the drug discovery process for our customers
faster, less expensive and more effective at generating drug candidates. We
focus on the portion of the drug discovery process that begins after
identification of a drug target through when a drug candidate is ready for
clinical trials. We develop, produce and sell collections of chemical compounds
that pharmaceutical and biotechnology companies test for their potential use as
new drugs or for use as the chemical starting point for new drugs. We also
develop, manufacture and sell proprietary instruments and the associated line of
consumable supplies that are used by the pharmaceutical and biotechnology
industries in their own in-house drug discovery chemistry operations.
Additionally, we provide testing services to our customers in which chemical
compounds are tested for their biological activity as potential drugs. We also
provide computational software tools that guide the entire process of chemical
compound design, development and testing. During the past nine months we
acquired three businesses: Discovery Technologies (DTL), Axys Advanced
Technologies (AAT) and Structural Proteomics (SPI).

RESULTS OF OPERATIONS FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2000 AND
1999

        Revenue. Total revenue increased 164% from the three months ended
September 30, 1999 to the three months ended September 30, 2000, and increased
146% from the nine months ended September 30, 1999 to the nine months ended
September 30, 2000. The increases in revenue result from internal growth as well
as contributions by our recently acquired businesses: Discovery Technologies
(completed in December, 1999), Axys Advanced Technologies (completed in April,
2000), and Structural Proteomics (completed in May, 2000).

        Gross margin. Gross margins increased from 37.6% for the three months
ended September 30, 1999 to 50.4% for the three months ended September 30, 2000,
and increased from 37.4% for the nine months ended September 30, 1999 to 48.5%
for the nine months ended September 30, 2000. The gross margin improvement
resulted from higher margins from screening revenue and compound library revenue
in our recently acquired businesses, as well as improved margins on our
historical product lines.

        Research and development expenses. Research and development expenses
consist primarily of salaries and benefits, supplies and expensed development
materials, and facilities costs and equipment depreciation. Research and
development expenses increased 264% ($2.0 million) from the three months ended
September 30, 1999 to the three months ended September 30, 2000 and increased
114% ($2.8 million) from the nine months ended September 30, 1999 to the nine
months ended September 30, 2000. Research and development expenses increased
primarily as a result of the three acquisitions we completed within the last
nine months. As a percentage of revenues, research



                                       8
<PAGE>   9

and development expenses increased from 20.1% for the three months ended
September 30, 1999 to 27.8% for the three months ended September 30, 2000, and
decreased from 24.6% for the nine months ended September 30, 1999 to 21.4% for
the nine months ended September 30, 2000. Research and development expenses
increased as a percentage of revenues during the three months ended September
30, 2000 primarily as a result of the acquisition of AAT, which has a
proportionally higher research and development expense level than the rest of
our Company.

        Selling, general and administrative expenses. Selling, general and
administrative expenses consist primarily of salaries and benefits for sales and
marketing and administrative personnel, advertising and promotional expenses,
professional services, and facilities costs. Selling, general and administrative
expenses increased 102% ($1.2 million) from the three months ended September 30,
1999 to the three months ended September 30, 2000 and increased 87% ($2.8
million) from the nine months ended September 30, 1999 to the nine months ended
September 30, 2000. Selling, general and administrative expenses decreased as a
percentage of revenue, from 29.9% for the three months ended September 30, 1999
to 22.8% for the three months ended September 30, 2000, and from 31.7% for the
nine months ended September 30, 1999 to 24.2% for the nine months ended
September 30, 2000. Selling, general and administrative expenses increased
primarily as a result of our three recent acquisitions, but increased less
rapidly than revenues due to certain resulting economies of scale.

        Stock-based compensation. During 1999 and the nine months ended
September 30, 2000, we granted stock options with exercise prices that were less
than the estimated fair value of the underlying shares of common stock on the
date of grant. As a result, we have recorded and will continue to record
deferred stock-based compensation over the period that these options vest. The
deferred stock-based compensation expense for the three months ended September
30, 2000 was approximately $377,000, compared to approximately $80,000 for the
three months ended September 30, 1999. The deferred stock-based compensation
expense for the nine months ended September 30, 2000 was approximately $986,000,
compared to approximately $217,000 for the nine months ended September 30, 1999.

        Amortization of goodwill. We recognized approximately $1.2 million and
$2.2 million in goodwill amortization expense for the three months and nine
months ended September 30, 2000, in connection with the three acquisitions we
completed during the last nine months. Goodwill is amortized straight-line over
ten years. All three acquisitions were accounted for as purchases. There was no
goodwill amortization expense during the first nine months of 1999.

        In-Process Research and Development. We incurred $9.0 million in expense
during the nine months ended September 30, 2000 as a result of the write-off of
in-process research and development acquired as part of the AAT acquisition.

        Interest income. We realized net interest income of approximately $1.0
million for the three months ended September 30, 2000, as compared to net
interest income of approximately $48,000 for the three months ended September
30, 1999. Interest earned during the three months ended September 30, 2000 was
primarily from the investment of the $94.7 million in net proceeds from our
initial public offering. We realized net interest expense of approximately
$299,000 for the nine months ended September 30, 2000, as compared to net
interest income of approximately $191,000 for the nine months ended September
30, 1999. The net interest expense incurred during the first nine months of 2000
was primarily a result of approximately $1.2 million in imputed interest expense
during the first three months of 2000 equal to the fair value of warrants that
were issued in connection with certain notes payable.

        Net profit (loss). Net profit (loss) increased from a loss of $0.5
million for the three months ended September 30, 1999 to a loss of $0.6 million
for the three months ended September 30, 2000, and from a loss of $2.0 million
for the nine months ended September 30, 1999 to a loss of $11.6 million for the
nine months ended September 30, 2000. Excluding the non-cash expenses of
stock-based compensation amortization, goodwill amortization and the one-time
write-off of in-process research and development associated with our recent
acquisitions, net profit (loss) increased to a profit of $0.9 million for the
three months ended September 30, 2000 and a profit of $0.6 million for the nine
months ended September 30, 2000, from a loss of $.6 million and a loss of $1.8
million for the same periods in the prior year.



                                       9
<PAGE>   10

LIQUIDITY AND CAPITAL RESOURCES

        We have funded our operations principally with $39.0 million of private
equity financings, $94.7 million of net proceeds from our initial public
offering, and $3.7 million in short-term and long-term debt and equipment
financing arrangements.

        At September 30, 2000, cash and cash equivalents totaled approximately
$97.2 million, compared to $2.9 million at December 31, 1999.

        Net cash used in operating activities for the nine months ended
September 30, 2000 was approximately $238,000. A net loss of $11.6 million was
offset by non-cash charges of $15.7 million, including a $9.0 write-off of
purchased in-process research and development. Accounts receivable increased by
$3.8 million of cash (offset by an increase in accounts payable of $1.3
million), due to increased revenue and associated expenses during the period.

        We currently anticipate investing up to $6.0 million through December
31, 2001 for leasehold improvements and capital equipment necessary to support
future revenue growth. Our actual future capital requirements will depend on a
number of factors, including our success in increasing sales of both existing
and new products and services, expenses associated with unforeseen litigation,
regulatory changes and competition and technological developments, and potential
future merger and acquisition activity. We believe our existing cash and cash
equivalents, plus any cash generated from operations, will be sufficient to fund
our operating expenses, debt obligations and capital requirements through at
least December 31, 2001.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

        Short-term investments. Our interest income is sensitive to changes in
the general level of U.S. interest rates, particularly since a significant
portion of our investments are and will be in short-term marketable securities.
Due to the nature and maturity of our short-term investments, we have concluded
that there is no material market risk exposure.

        Foreign currency rate fluctuations. The functional currency for the
European operations of our IRORI group is the U.S. dollar, and the functional
currency for our Discovery Technologies group is the Swiss franc. Our subsidiary
accounts are translated from their local currency to the U.S. dollar using the
current exchange rate in effect at the balance sheet date for the balance sheet
accounts, and using the average exchange rate during the period for revenues and
expense accounts. The effects of translation for the European operations of our
IRORI group are recorded as foreign currency gains (losses) in the consolidated
statement of operations. The effects of translation for our Discovery
Technologies group are recorded as a separate component of stockholders' equity.
Our European subsidiaries conduct their business with customers in local
currencies. Exchange gains and losses arising from these transactions are
recorded using the actual exchange differences on the date of the transaction.
We have not taken any action to reduce our exposure to changes in foreign
currency exchange rates, such as options or futures contracts, with respect to
transactions with our European subsidiaries or transactions with our worldwide
customers. The net tangible assets of our two European subsidiaries combined
were $6.8 million at September 30, 2000. A 1% decrease in the value of the
British pound and Swiss franc relative to the U.S. dollar would result in a
foreign translation loss of $68,000.

        Inflation. We do not believe that inflation has had a material impact on
our business or operating results during the periods presented.



                                       10
<PAGE>   11

                             RISKS AND UNCERTAINTIES

        In addition to the other information contained herein, you should
carefully consider the following risk factors in evaluating our company.


                          RISKS RELATED TO OUR BUSINESS

WE RECENTLY HAVE ACQUIRED SEVERAL BUSINESSES AND FACE RISKS ASSOCIATED WITH
INTEGRATING THESE BUSINESSES AND POTENTIAL FUTURE ACQUISITIONS.

        We recently completed the acquisitions of Axys Advanced Technologies
(AAT), Discovery Technologies and 75% of the stock of Structural Proteomics, and
are in the process of integrating these businesses. We plan to continue to
review potential acquisition candidates in the ordinary course of our business
and our strategy includes building our business through acquisitions.
Acquisitions involve numerous risks, including among others, difficulties and
expenses incurred in the consummation of acquisitions and assimilation of the
operations, personnel and services or products of the acquired companies,
difficulties of operating new businesses, the diversion of management's
attention from other business concerns and the potential loss of key employees
of the acquired company. For example, distance and cultural differences may make
it difficult for us to successfully assimilate the operations of our recently
acquired assay development and high throughput screening operations (Discovery
Technologies) located in Switzerland with our medicinal chemistry operations
located in San Diego. Further, integrating the chemistry operations performed by
AAT with our existing ChemRx chemistry operations will cause some key employees
to have overlapping functional roles, which may lead to their departure if they
are unable or unwilling to assume new or different roles within our merged
organization. If we do not successfully integrate the three businesses we
recently acquired or any businesses we may acquire in the future, our business
will suffer. Additionally, acquisition candidates may not be available in the
future or may not be available on terms and conditions acceptable to us.
Acquisitions of foreign companies also may involve additional risks of
assimilating different business practices, overcoming language and cultural
barriers and foreign currency translation. We currently have no agreements or
commitments with respect to any acquisition and we may never successfully
complete any additional acquisitions.

WE MAY NOT ACHIEVE OR SUSTAIN PROFITABILITY IN THE FUTURE.

        We are at an early stage of executing our business plan. We have
incurred operating and net losses since our inception. As of September 30, 2000,
we had an accumulated deficit of $31.3 million. For the years ended December 31,
1997, 1998 and 1999 and the nine months ended September 30, 2000, we had net
losses of $4.8 million, $6.3 million, $3.4 million, and $11.6 million,
respectively. We may also in the future incur operating and net losses and
negative cash flow from operations, due in part to anticipated increases in
expenses for research and product development, acquisitions of complementary
businesses and technologies and expansion of our sales and marketing
capabilities. We incurred no goodwill charges in the years ended 1997, 1998 and
1999. We incurred goodwill charges in the amount of $2.2 million for the nine
months ended September 30, 2000. Beginning in July 2000, goodwill charges for
acquisitions we have already made will be at a straight-line rate of $397,000
per month, or $4.8 million per year, for the next ten years. Given our
acquisition strategy, we expect significant goodwill charges to affect our net
income (loss) for the foreseeable future. We may not be able to achieve or
maintain profitability. Moreover, if we do achieve profitability, the level of
any profitability cannot be predicted and may vary significantly from quarter to
quarter.

WE MAY INCUR EXCHANGE LOSSES WHEN FOREIGN CURRENCY USED IN INTERNATIONAL
TRANSACTIONS IS CONVERTED INTO U.S. DOLLARS.

        For the nine months ending September 30, 2000, 6.4% of our actual
revenue was invoiced and our corresponding expenses were incurred in foreign
currency, including the British pound, the Swiss franc and the Euro. Currency
fluctuations between the U.S. dollar and the currencies in which we do business
will cause foreign currency translation gains and losses. We cannot predict the
effects of exchange rate fluctuations on our future operating results because of
the number of currencies involved, changes in the percentage of our revenue
which will



                                       11
<PAGE>   12

be invoiced in foreign currencies, the variability of currency exposure and the
potential volatility of currency exchange rates. We do not currently engage in
foreign exchange hedging transactions to manage our foreign currency exposure.

IF OUR PRODUCTS AND SERVICES DO NOT BECOME WIDELY USED IN THE PHARMACEUTICAL AND
BIOTECHNOLOGY INDUSTRIES, IT IS UNLIKELY THAT WE WILL BE PROFITABLE.

        We have a limited history of offering our products and services,
including our NanoKan System, informatics tools and collections of chemical
compounds. It is uncertain whether our current customers will continue to use
these products and services or whether new customers will use these products and
services. In order to be successful, our products and services must meet the
requirements of the pharmaceutical and biotechnology industries, and we must
convince potential customers to use our products and services instead of
competing technologies. Market acceptance will depend on many factors, including
our ability to:

        -  convince potential customers that our technologies are attractive
           alternatives to other technologies for drug discovery;

        -  manufacture products and conduct services in sufficient quantities
           with acceptable quality and at an acceptable cost;

        -  convince potential customers to purchase drug discovery products and
           services from us rather than developing them internally; and

        -  place and service sufficient quantities of our products.

Because of these and other factors, our products and services may not gain
market acceptance.

WE MAY FAIL TO EXPAND CUSTOMER RELATIONSHIPS THROUGH INTEGRATION OF PRODUCTS AND
SERVICES.

        We may not be successful in selling our offerings in combination across
the range of drug discovery disciplines we serve because integrated combinations
of our products and services may not achieve time and cost efficiencies for our
customers. In addition, we may not succeed in further integrating our offerings.
We may not be able to use existing relationships with customers in individual
areas of our business to sell products and services in multiple areas of drug
discovery. If we do not achieve integration of our products and services, we may
not be able to take advantage of potential revenue opportunities.

OUR SUCCESS WILL DEPEND ON OUR ABILITY TO MANAGE RAPID GROWTH AND EXPANSION.

        Growth in our operations has placed and, if we grow in the future, will
continue to place a significant strain on our operational, human and financial
resources. We recently have acquired three new businesses and we intend to
continue to grow our business. We have not expanded our management and
infrastructure in advance of anticipated growth. Therefore, as we expand our
operations we will not necessarily have in place infrastructure and personnel
sufficient to accommodate the increased size of our business. Our ability to
manage effectively any growth through acquisitions or any internal growth will
depend, in large part, on our ability to hire, train and assimilate additional
management, professional, scientific and technical personnel and our ability to
expand, improve and effectively use our operating, management, marketing and
financial systems to accommodate our expanded operations. These tasks are made
more difficult as we acquire businesses in geographically disparate locations,
such as our recent acquisitions of Discovery Technologies in Switzerland, AAT in
the San Francisco area, and Structural Proteomics in New Jersey.

OUR DIRECTED SORTING PRODUCTS AND OUR LARGE COMPOUND LIBRARIES HAVE LENGTHY
SALES CYCLES, WHICH COULD CAUSE OUR OPERATING RESULTS TO FLUCTUATE SIGNIFICANTLY
FROM QUARTER TO QUARTER.

        Sales of our Directed Sorting products and our large compound libraries
typically involve significant technical evaluation and commitment of capital by
our customers. Accordingly, the sales cycles, or the time from finding a
prospective customer through closing the sale, associated with these products,
range from six to eighteen



                                       12
<PAGE>   13

months. Sales of these products are subject to a number of significant risks,
including customers' budgetary constraints and internal acceptance reviews that
are beyond our control. Due to these lengthy and unpredictable sales cycles, our
operating results could fluctuate significantly from quarter to quarter. We
expect to continue to experience significant fluctuations in quarterly operating
results due to a variety of factors, such as general and industry specific
economic conditions which may affect the research and development expenditures
of pharmaceutical and biotechnology companies.

        A large portion of our expenses, including expenses for facilities,
equipment and personnel, are relatively fixed. Accordingly, if revenues decline
or do not grow as anticipated, we might not be able to correspondingly reduce
our operating expenses. Failure to achieve anticipated levels of revenues could
therefore significantly harm our operating results for a particular fiscal
period.

        Due to the possibility of fluctuations in our revenues and expenses, we
believe that quarter-to-quarter comparisons of our operating results are not a
good indication of our future performance.

WE DEPEND ON THIRD-PARTY PRODUCTS AND SERVICES AND SOLE OR LIMITED SOURCES OF
SUPPLY TO MANUFACTURE SOME COMPONENTS OF OUR DIRECTED SORTING PRODUCTS.

        We rely on outside vendors to manufacture components and subassemblies
used in our Directed Sorting products. Some of these components and
subassemblies are obtained from a single supplier or a limited group of
suppliers. We depend on sole-source suppliers for the mesh component of our
reactors, the radio frequency (RF) tags used in our commercial products and the
two-dimensional bar code tags used in our NanoKan System. These materials are
obtained from suppliers on standard commercial terms, and we do not have
long-term supply agreements with any of these suppliers. Our reliance on outside
vendors generally, and a sole or limited group of suppliers in particular,
involves several risks, including:

        -  the inability to obtain an adequate supply of required components due
           to manufacturing capacity constraints, a discontinuance of a product
           by a third-party manufacturer or other supply constraints;

        -  reduced control over quality and pricing of components; and

        -  delays and long lead times in receiving materials from vendors.

WE HAVE NOT YET INSTALLED OUR SECOND NANOKAN SYSTEM; ALSO, WE FACE RESTRICTIONS
ON OUR ABILITY TO SELL THIS PRODUCT TO ADDITIONAL CUSTOMERS.

        We have not yet installed our second NanoKan System that we currently
are developing for sale to Bristol-Myers Squibb. We may not be able to
successfully complete installation of the NanoKan System and, after
installation, it may not meet our customers' expectations. Further, under
agreements with Bristol-Myers Squibb and Aventis, we are prohibited from
delivering the NanoKan System to any additional customers until a date which has
now been fixed as October 6, 2001. We have delivered and installed the first
system and expect to install the second system before the end of 2000; however,
delivery may be delayed beyond 2000 due to factors beyond our control, such as
unexpected development problems or natural disasters.

OUR CUSTOMERS MAY RESTRICT OUR USE OF SCIENTIFIC INFORMATION, WHICH COULD
PREVENT US FROM USING THIS INFORMATION FOR ADDITIONAL REVENUE.

        We plan to generate and use information that is not proprietary to our
customers and that we derive from performing drug discovery services for our
customers. However, our customers may not allow us to use information such as
the general interaction between types of chemistries and types of drug targets
that we generate when performing drug discovery services for them. Our current
contracts restrict our use of scientific information we generate for our
customers, such as the biological activity of chemical compounds with respect to
drug targets, and future contracts also may restrict our use of scientific
information. To the extent that our use of information is restricted, we may not
be able to collect and aggregate scientific data and take advantage of potential
revenue opportunities.



                                       13
<PAGE>   14

OUR OPERATIONS COULD BE INTERRUPTED BY DAMAGE TO OUR FACILITIES.

        Our results of operations are dependent upon the continued use of our
highly specialized laboratories and equipment. Our operations are primarily
concentrated in facilities in San Diego, California South San Francisco,
California and near Basel, Switzerland. Natural disasters, such as earthquakes,
could damage our laboratories or equipment and these events may materially
interrupt our business. We maintain business interruption insurance to cover
lost revenues caused by such occurrences. However, this insurance would not
compensate us for the loss of opportunity and potential adverse impact on
relations with existing customers created by an inability to meet our customers'
needs in a timely manner.


                   RISKS RELATED TO OPERATING IN OUR INDUSTRY

THE CONCENTRATION OF THE PHARMACEUTICAL INDUSTRY AND THE CURRENT TREND TOWARD
INCREASING CONSOLIDATION COULD HURT OUR BUSINESS PROSPECTS.

        The market for our products and services is highly concentrated, with
approximately 50 large pharmaceutical companies conducting drug discovery
research. The continuation of the current trend toward consolidation of the
pharmaceutical industry may reduce the number of our potential customers even
further. Accordingly, we expect that a relatively small number of customers will
account for a substantial portion of our revenues. During the three months ended
September 30, 2000, net revenue from our three largest customers represented
approximately 17%, 11% and 11% of total net revenue, respectively.

        Additional risks associated with a highly concentrated customer base
include:

        -  fewer customers for our products and services;

        -  larger companies may develop in-house technology and expertise rather
           than using our products and services;

        -  larger customers may negotiate price discounts or other terms for our
           products and services that are unfavorable to us; and

        -  the market for our products and services may become saturated.

        For example, because of the heavy concentration of the pharmaceutical
industry and the high cost of our NanoKan System, we expect to sell only a small
number of NanoKan Systems before we saturate the market for this product. When
we are no longer able to sell additional NanoKan Systems, we will be dependent
upon the sale of consumables for revenue from this product line. Similarly,
there are signs that the market for our AutoSort System is becoming saturated.

THE DRUG DISCOVERY INDUSTRY IS COMPETITIVE AND SUBJECT TO TECHNOLOGICAL CHANGE,
AND WE MAY NOT HAVE THE RESOURCES NECESSARY TO COMPETE SUCCESSFULLY.

        We compete with companies in the United States and abroad that engage in
the development and production of drug discovery products and services. These
competitors include companies engaged in the following areas of drug discovery:

        -  Assay, development and screening, including Aurora Biosciences and
           Pharmacopeia;

        -  Combinatorial chemistry instruments, including Argonaut and Bohdan;

        -  Compound libraries and lead optimization, including Albany Molecular
           Research and Arqule; and

        - Informatics, including the MSI division of Pharmacopeia.



                                       14
<PAGE>   15

        Academic institutions, governmental agencies and other research
organizations also conduct research in areas in which we provide services,
either on their own or through collaborative efforts. Also, essentially all of
our pharmaceutical company customers have internal departments which provide
some of the products and services which we sell, so these customers may have
limited needs for our products and services. Many of our competitors including
Pharmacopeia have access to greater financial, technical, research, marketing,
sales, distribution, service and other resources than we do.

        Moreover, the pharmaceutical and biotechnology industries are
characterized by continuous technological innovation. We anticipate that we will
face increased competition in the future as new companies enter the market and
our competitors make advanced technologies available. Technological advances or
entirely different approaches that we or one or more of our competitors develop
may render our products, services and expertise obsolete or uneconomical. For
example, advances in informatics and virtual screening may render some of our
technologies, such as our large compound libraries, obsolete. Additionally, the
existing approaches of our competitors or new approaches or technologies that
our competitors develop may be more effective than those we develop. We may not
be able to compete successfully with existing or future competitors.

OUR SUCCESS WILL DEPEND ON THE PROSPECTS OF THE PHARMACEUTICAL AND BIOTECHNOLOGY
INDUSTRIES AND THE EXTENT TO WHICH THESE INDUSTRIES USE THIRD-PARTY ASSISTANCE
WITH ONE OR MORE ASPECTS OF THEIR DRUG DISCOVERY PROCESS.

        Our revenues depend to a large extent on research and development
expenditures by the pharmaceutical, biotechnology and agricultural industries
and companies in these industries outsourcing research and development projects.
These expenditures are based on a wide variety of factors, including the
resources available for purchasing research equipment, the spending priorities
among various types of research and policies regarding expenditures during
recessionary periods. General economic downturns in our customers' industries or
any decrease in research and development expenditures could harm our operations.
Any decrease in drug discovery spending by pharmaceutical and biotechnology
companies could cause our revenues to decline and adversely impact our
profitability.

OUR SUCCESS WILL DEPEND ON OUR ABILITY TO ATTRACT AND RETAIN KEY EXECUTIVES, AND
EXPERIENCED SCIENTISTS AND SALES PERSONNEL.

        Our future success will depend to a significant extent on our ability to
attract, retain and motivate highly skilled scientists and sales personnel. In
addition, our business would be significantly harmed if we lost the services of
Riccardo Pigliucci, our chief executive officer, or David Coffen, our chief
scientific officer. Our ability to maintain, expand or renew existing
engagements with our customers, enter into new engagements and provide
additional services to our existing customers depends, in large part, on our
ability to hire and retain scientists with the skills necessary to keep pace
with continuing changes in drug discovery technologies and sales personnel who
are highly motivated. Additionally, is difficult for us to find qualified sales
personnel in light of the fact that our sales personnel generally hold Ph.D's.
Our employees are "at will" which means that they may resign at any time, and we
may dismiss them at any time. We believe that there is a shortage of, and
significant competition for, scientists with the skills and experience in the
sciences necessary to perform the services we offer. We compete with
pharmaceutical companies, biotechnology companies, combinatorial chemistry
companies, contract research companies and academic institutions for new
personnel. In addition, our inability to hire additional qualified personnel may
require an increase in the workload for both existing and new personnel. We may
not be successful in attracting new scientists or sales personnel or in
retaining or motivating our existing personnel.

THE INTELLECTUAL PROPERTY RIGHTS WE RELY ON TO PROTECT THE TECHNOLOGY UNDERLYING
OUR PRODUCTS AND TECHNIQUES MAY NOT BE ADEQUATE, WHICH COULD ENABLE THIRD
PARTIES TO USE OUR TECHNOLOGY OR VERY SIMILAR TECHNOLOGY AND COULD REDUCE OUR
ABILITY TO COMPETE IN THE MARKET.

        Our success will depend on our ability to obtain, protect and enforce
patents on our technology and to protect our trade secrets. We also depend, in
part, on patent rights that third parties license to us. Any patents we own or
license may not afford meaningful protection for our technology and products.
Others may challenge our patents or the patents of our licensors and, as a
result, these patents could be narrowed, invalidated or rendered unenforceable.
In addition, current and future patent applications on which we depend may not
result in the issuance of patents in the United States or foreign countries.
Competitors may develop products similar to ours



                                       15
<PAGE>   16

which are not covered by our patents. Further, since there is a substantial
backlog of patent applications at the U.S. Patent and Trademark Office, the
approval or rejection of our or our competitors' patent applications may take
several years.

        In addition to patent protection, we also rely on copyright protection,
trade secrets, know-how, continuing technological innovation and licensing
opportunities. In an effort to maintain the confidentiality and ownership of our
trade secrets and proprietary information, we require our employees, consultants
and advisors to execute confidentiality and proprietary information agreements.
However, these agreements may not provide us with adequate protection against
improper use or disclosure of confidential information and there may not be
adequate remedies in the event of unauthorized use or disclosure. Furthermore,
like many technology companies, we may from time to time hire scientific
personnel formerly employed by other companies involved in one or more areas
similar to the activities conducted by us. In some situations, our
confidentiality and proprietary information agreements may conflict with, or be
subject to, the rights of third parties with whom our employees, consultants or
advisors have prior employment or consulting relationships. Although we require
our employees and consultants to maintain the confidentiality of all
confidential information of previous employers, their prior affiliations may
subject us or these individuals to allegations of trade secret misappropriation
or other similar claims. Finally, others may independently develop substantially
equivalent proprietary information and techniques, or otherwise gain access to
our trade secrets. Our failure to protect our proprietary information and
techniques may inhibit or limit our ability to exclude certain competitors from
the market.

THE DRUG DISCOVERY INDUSTRY HAS A HISTORY OF INTELLECTUAL PROPERTY LITIGATION
AND WE MAY BE INVOLVED IN INTELLECTUAL PROPERTY LAWSUITS, WHICH MAY BE
EXPENSIVE.

        In order to protect or enforce our patent rights, we may have to
initiate legal proceedings against third parties. In addition, others may sue us
for infringing their intellectual property rights or we may find it necessary to
initiate a lawsuit seeking a declaration from a court that we are not infringing
the proprietary rights of others. The patent positions of pharmaceutical,
biotechnology and drug discovery companies are generally uncertain. A number of
pharmaceutical companies, biotechnology companies, independent researchers,
universities and research institutions may have filed patent applications or may
have been granted patents that cover technologies similar to the technologies
owned by, or licensed to, us or our collaborators. For instance, a number of
patents may have been issued or may be issued in the future that could cover
certain aspects of our technology that could prevent us from using technology
that we use or expect to use. In addition, we are unable to determine all of the
patents or patent applications that may materially affect our ability to make,
use or sell any potential products. Legal proceedings relating to intellectual
property would be expensive, take significant time and divert management's
attention from other business concerns, no matter whether we win or lose. The
cost of such litigation could affect our profitability.

        Further, an unfavorable judgment in an infringement lawsuit brought
against us, in addition to any damages we might have to pay, could require us to
stop the infringing activity or obtain a license. Any required license may not
be available to us on acceptable terms, or at all. In addition, some licenses
may be nonexclusive, and therefore, our competitors may have access to the same
technology licensed to us. If we fail to obtain a required license or are unable
to design around a patent, we may be unable to sell some of our products or
services.

WE MAY BE SUBJECT TO LIABILITY REGARDING HAZARDOUS MATERIALS.

        Our products and services as well as our research and development
processes involve the controlled use of hazardous materials. For example, we
sometimes use acids, bases, oxidants, and flammable materials. Acids include
trifluoroacetic acid and hydrochloric acid, bases include sodium hydroxide and
triethylamine, oxidants include peracids and potassium permanganate, and
flammable solvents include methanol, hexane and tetrahydrofuran. We are subject
to federal, state and local laws and regulations governing the use, manufacture,
storage, handling and disposal of such materials and certain waste products. We
cannot completely eliminate the risk of accidental contamination or injury from
these materials. In the event of such an accident, we could be held liable for
any damages that result, and any such liability could exceed our resources and
disrupt our business. In addition, we may have to incur significant costs to
comply with environmental laws and regulations related to the handling or
disposal of such materials or waste products in the future, which would require
us to spend substantial amounts of money.



                                       16
<PAGE>   17

                          OTHER RISKS AND UNCERTAINTIES

OUR STOCK PRICE LIKELY WILL BE VOLATILE.

        The trading price of our common stock likely will be volatile and could
be subject to fluctuations in price in response to various factors, many of
which are beyond our control, including:

        -  actual or anticipated variations in quarterly operating results;

        -  announcements of technological innovations by us or our competitors;

        -  new products or services introduced or announced by us or our
           competitors;

        -  changes in financial estimates by securities analysts;

        -  conditions or trends in the pharmaceutical and biotechnology
           industries;

        -  announcements by us or our competitors of significant acquisitions,
           strategic partnerships, joint ventures or capital commitments;

        -  additions or departures of key personnel;

        -  economic and political factors; and

        -  sales of our common stock.

        In addition, price and volume fluctuations in the stock market in
general, and the Nasdaq National Market and the market for technology companies
in particular, have often been unrelated or disproportionate to the operating
performance of those companies. Further, the market prices of securities of life
sciences companies have been particularly volatile. Conditions or trends in the
pharmaceutical and biotechnology industries generally may cause further
volatility in the trading price of our common stock, because the market may
incorrectly perceive us as a pharmaceutical or biotechnology company. These
broad market and industry factors may harm the market price of our common stock,
regardless of our operating performance. In the past, plaintiffs have often
instituted securities class action litigation following periods of volatility in
the market price of a company's securities. A securities class action suit
against us could result in potential liabilities, substantial costs and the
diversion of management's attention and resources, regardless of whether we win
or lose.

OUR EXECUTIVE OFFICERS, DIRECTORS AND PRINCIPAL STOCKHOLDERS OWN A LARGE
PERCENTAGE OF OUR VOTING STOCK AND COULD DELAY OR PREVENT A CHANGE IN OUR
CORPORATE CONTROL OR OTHER MATTERS REQUIRING STOCKHOLDER APPROVAL, EVEN IF
FAVORED BY OUR OTHER STOCKHOLDERS.

        Our executive officers, directors and principal stockholders, and their
respective affiliates, beneficially own approximately 63.7% of our outstanding
common stock. These stockholders, if acting together, would be able to control
substantially all matters requiring approval by our stockholders, including the
election of all directors and approval of significant corporate transactions. We
have agreed to include, as director nominees, a number of nominees of Axys
Pharmaceuticals, Inc. which is proportionate to Axys' percentage ownership of
our shares. Axys Pharmaceuticals, Inc. has the right to nominate for election
two of seven directors. Axys Pharmaceuticals, Inc., which owns approximately
31.7% of our common stock, has agreed to vote all of its stock in favor of
management's annual slates of director nominees.

BECAUSE IT IS UNLIKELY THAT WE WILL PAY DIVIDENDS, YOU WILL ONLY BE ABLE TO
BENEFIT FROM HOLDING OUR STOCK IF THE STOCK PRICE APPRECIATES.

        We have never paid cash dividends on our capital stock and do not
anticipate paying any cash dividends in the foreseeable future.



                                       17
<PAGE>   18

ANTI-TAKEOVER PROVISIONS IN OUR CHARTER AND BYLAWS COULD MAKE A THIRD-PARTY
ACQUISITION OF US DIFFICULT.

        Our certificate of incorporation and bylaws contain provisions that
could make it more difficult for a third party to acquire us, even if doing so
would be beneficial to our stockholders. These provisions could limit the price
that investors might be willing to pay in the future for shares of our common
stock.



                                       18
<PAGE>   19

                     DISCOVERY PARTNERS INTERNATIONAL, INC.

                                     PART II
                                OTHER INFORMATION



ITEM 1. LEGAL PROCEEDINGS

None.

ITEM 2. CHANGES IN SECURITIES AND USE OF PROCEEDS

        (d) Use of Proceeds.

                On August 1, 2000, we closed the sale of 5,000,000 shares of our
        Common Stock, $0.001 par value, in our initial public offering (the
        "Offering"), and on August 30, 2000 we closed the sale of an additional
        750,000 shares of Common Stock pursuant to the exercise of the
        underwriters' overallotment option in the offering. The managing
        underwriters in the Offering were Chase Securities Inc., Lehman Brothers
        Inc. and UBS Warburg LLC (the "Underwriters"). The shares of Common
        Stock sold in the Offering were registered under the 1933 Act on a
        Registration Statement on Form S-1 (the "Registration Statement") (Reg.
        No. 333-36638) that was declared effective by the SEC on July 27, 2000.
        The Offering commenced on July 27, 2000. All 5,750,000 shares of Common
        Stock registered under the Registration Statement, including shares
        covered by an overallotment option that was exercised, were sold at a
        price per share of $18.00. The aggregate price of the Offering amount
        registered was $103,500,000. In connection with the Offering, we paid an
        aggregate of $7,245,000 in underwriting discounts and commissions to the
        Underwriters. In addition, the following table sets forth all expenses
        incurred in connection with the Offering, other than underwriting
        discounts and commissions. Most of these expenses were actually paid
        after the effective date of the registration statement.

<TABLE>
        <S>                                                       <C>
        SEC registration fee                                      $   30,360
        NASD filing fee                                               12,000
        Nasdaq National Market listing fee                            95,000
        Legal fees and expenses                                      658,090
        Accounting fees and expenses                                 340,000
        Printing and engraving                                       272,432
        Blue Sky fees and expenses (including legal fees)              5,000
        Transfer agent fees                                            3,500
        Miscellaneous                                                184,330
                                                                  ----------
                Total                                             $1,600,712
                                                                  ==========
</TABLE>

                After deducting the underwriting discounts and commissions and
        the Offering expenses described above, we received net proceeds from the
        Offering of approximately $94.7 million. We intend to use the proceeds
        to fund our operations, including continued development and
        manufacturing of existing products as well as research and development
        of additional products and services. We may also use a portion of the
        net proceeds to acquire new businesses or technologies, hire additional
        personnel and expand our facilities to be able to meet the growing needs
        of our business. In addition, we may, if the opportunity arises, use an
        unspecified portion of the net proceeds to acquire or invest in
        products, technologies or companies. We intend to use the balance of the
        net proceeds for general corporate purposes, including working capital.
        None of the net proceeds of the Offering were paid directly or
        indirectly to any directors, officers, general partners of our company
        or their associates, persons owning 10% or more of any class of our
        equity securities, or affiliates of ours.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

None.



                                       19
<PAGE>   20

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

None.

ITEM 5. OTHER INFORMATION

None.

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

        (a)     Exhibits:

                27.1    Financial Data Schedule

        (b)     Reports on Form 8-K:

                There were no reports on Form 8-K filed during the quarter ended
        September 30, 2000.



                                       20
<PAGE>   21

                     DISCOVERY PARTNERS INTERNATIONAL, INC.
                                   SIGNATURES


        Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.




                                       DISCOVERY PARTNERS INTERNATIONAL, INC.



Date: November 14, 2000                By: /s/ RICCARDO PIGLIUCCI
               --                          -------------------------------------
                                           Riccardo Pigliucci
                                           Chief Executive Officer
                                           (Duly Authorized Officer)




Date: November 14, 2000                By: /s/ JACK FITZPATRICK
               --                          -------------------------------------
                                           Jack Fitzpatrick
                                           Chief Financial Officer, Vice
                                           President Finance and Administration
                                           and Secretary (Principal Financial
                                           and Accounting Officer)



                                       21


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