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<PAGE> 1 Exhibit 21.1 The following is a list of all subsidiaries of The Medicines Company: <TABLE> <CAPTION> NAME OF SUBSIDIARY JURISDICTION OF INCORPORATION OWNERSHIP ------------------ ----------------------------- PERCENTAGE ---------- <S> <C> <C> The Medicines Company, Limited United Kingdom 100% The Medicines Company, Limited New Zealand 100% The Medicines Securities Corporation Massachusetts 100% </TABLE>
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