MEDICINES CO/ MA
S-1, EX-21.1, 2001-01-05
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
                                                                    Exhibit 21.1


The following is a list of all subsidiaries of The Medicines Company:


<TABLE>
<CAPTION>
NAME OF SUBSIDIARY                      JURISDICTION OF INCORPORATION      OWNERSHIP
------------------                      -----------------------------     PERCENTAGE
                                                                          ----------
<S>                                     <C>                                <C>
The Medicines Company, Limited                 United Kingdom                 100%
The Medicines Company, Limited                   New Zealand                  100%
The Medicines Securities Corporation            Massachusetts                 100%
</TABLE>


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