MEDICHEM LIFE SCIENCES INC
S-1/A, EX-1.1, 2000-10-13
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                     Exhibit 1.1





                         MediChem Life Sciences, Inc.

                                    Shares

                                 Common Stock
                               ($0.01 Par Value)

                            UNDERWRITING AGREEMENT

October  , 2000
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                             UNDERWRITING AGREEMENT

                                                                 October  , 2000

UBS Warburg LLC
Chase Securities, Inc.
William Blair & Company, L.L.C.
as Representatives to the Several Underwriters
named on Schedule A hereto

c/o UBS Warburg LLC
299 Park Avenue
New York, New York  10171-0026

Ladies and Gentlemen:

          MediChem Life Sciences, Inc., a Delaware corporation (the Company),
proposes to issue and sell to the underwriters named in Schedule A annexed
hereto (the Underwriters) an aggregate of 6,400,000 shares (the Firm Shares) of
Common Stock, $0.01 par value per share (the Common Stock), of the Company.  In
addition, solely for the purpose of covering over-allotments, the Company
proposes to grant to the Underwriters the option to purchase from the Company up
to an additional 960,000 shares of Common Stock (the Additional Shares).  The
Firm Shares and the Additional Shares are hereinafter collectively sometimes
referred to as the Shares.  The Shares are described in the Prospectus which is
referred to below.

          The Company hereby acknowledges that in connection with the proposed
offering of the Shares, it has requested UBS Warburg LLC (UBSW) to administer a
directed share program (the Directed Share Program) under which up to 320,000
shares of the Firm Shares to be purchased by you (the Reserved Shares) shall be
reserved for sale by you at the initial public offering price to the Company's
officers, directors, employees, and consultants and others having a business
relationship with the Company (the Directed Share Participants) as part of the
distribution of the Shares by the Underwriters, subject to the terms of this
Agreement, the applicable rules, regulations and interpretations of the National
Association of Securities Dealers, Inc. and all other applicable laws, rules and
regulations. The number of Shares available for sale to the general public will
be reduced to the extent that Directed Share Participants purchase Reserved
Shares. You may offer any Reserved Shares not purchased by Directed Share
Participants to the general public on the same basis as the other Shares being
issued and sold hereunder. The
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Company has supplied UBSW with the names, addresses and telephone numbers of the
individuals or other entities which the Company has designated to be
participants in the Directed Share Program. It is understood that any number of
those designated to participate in the Directed Share Program may decline to do
so.

          The Company has filed, in accordance with the provisions of the
Securities Act of 1933, as amended, and the rules and regulations thereunder
(collectively called the Act), with the Securities and Exchange Commission (the
Commission) a registration statement on Form S-1 (File No. 333-39548) including
a prospectus, relating to the Shares.  The Company has furnished to you, for use
by the Underwriters and by dealers, copies of one or more preliminary
prospectuses (each thereof being herein called a Preliminary Prospectus)
relating to the Shares.  Except where the context otherwise requires, the
registration statement, as amended when it becomes effective, including all
documents filed as a part thereof, and including any information contained in a
prospectus subsequently filed with the Commission pursuant to Rule 424(b) under
the Act and deemed to be part of the registration statement at the time of
effectiveness pursuant to Rule 430(A) under the Act, and also including any
registration statement filed pursuant to Rule 462(b) under the Act, is herein
called the Registration Statement, and the prospectus, in the form filed by the
Company with the Commission pursuant to Rule 424(b) under the Act on or before
the second business day after the date hereof (or such earlier time as may be
required under the Act) or, if no such filing is required, the form of final
prospectus included in the Registration Statement at the time it became
effective, is herein called the Prospectus.

          As described in the Registration Statement and the Prospectus, prior
to the time of purchase (as defined herein), the Company will be a wholly-owned
subsidiary of MCR Holdings, Inc. (MCR Holdings), an Illinois corporation.
Immediately prior to the time of purchase, MCR Holdings will merge with and into
the Company.  As a result of these actions, existing MCR Holdings' stockholders
automatically will become Company stockholders and the Company then will own all
of the outstanding shares of ThermoGen, Inc. (ThermoGen) and Emerald
BioStructures, Inc. (Emerald). The reorganization and related transactions
discussed in the Registration Statement and Prospectus under the caption
"CORPORATE REORGANIZATION" are collectively referred to herein as the
Reorganization.

          The Company and the Underwriters agree as follows:

          1.   Sale and Purchase. Upon the basis of the warranties and
representations and subject to the terms and conditions herein set forth, the
Company agrees to sell to the respective Underwriters and each of the
Underwriters, severally and not jointly, agrees to purchase from the Company the
aggregate number of Firm Shares set forth opposite the name of such Underwriter
in
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Schedule A attached hereto in each case at a purchase price of $______ per
Share. The Company is advised by you that the Underwriters intend (i) to make a
public offering of their respective portions of the Firm Shares as soon after
the effective date of the Registration Statement as in your judgment is
advisable and (ii) initially to offer the Firm Shares upon the terms set forth
in the Prospectus. You may from time to time increase or decrease the public
offering price after the initial public offering to such extent as you may
determine.

          It is further understood that UBSW will act as, and has authority to
act as, the representative for the Underwriters in the offering and sale of the
Shares in accordance with a master agreement among Underwriters entered into by
you and the several Underwriters.

          In addition, the Company hereby grants to the several Underwriters the
option to purchase, and upon the basis of the warranties and representations and
subject to the terms and conditions herein set forth, the Underwriters shall
have the right to purchase, severally and not jointly, from the Company, ratably
in accordance with the number of Firm Shares to be purchased by each of them,
all or a portion of the Additional Shares as may be necessary to cover over-
allotments made in connection with the offering of the Firm Shares, at the same
purchase price per share to be paid by the Underwriters to the Company for the
Firm Shares.  This option may be exercised by you on behalf of the several
Underwriters at any time and from time to time on or before the thirtieth day
following the date hereof, by written notice to the Company.  Such notice shall
set forth the aggregate number of Additional Shares as to which the option is
being exercised, and the date and time when the Additional Shares are to be
delivered (such date and time being herein referred to as the additional time of
purchase); provided, however, that the additional time of purchase shall not be
earlier than the time of purchase (as defined below) nor earlier than the second
business day/1/ after the date on which the option shall have been exercised nor
later than the tenth business day after the date on which the option shall have
been exercised.  The number of Additional Shares to be sold to each Underwriter
shall be the number which bears the same proportion to the aggregate number of
Additional Shares being purchased as the number of Firm Shares set forth
opposite the name of such Underwriter on Schedule A hereto bears to the total
number of Firm Shares (subject, in each case, to such adjustment as you may
determine to eliminate fractional shares).


     2.   Payment and Delivery. Payment of the purchase price for the Firm
Shares shall be made to the Company by Federal Funds wire transfer, against

------------------
/1/  As used herein "business day" shall mean a day on which the New York Stock
Exchange is open for trading.

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delivery of the certificates for the Firm Shares to you through the facilities
of the Depository Trust Company (DTC) for the respective accounts of the
Underwriters. Such payment and delivery shall be made at 10:00 A.M., New York
City time, on _____, 2000 (unless another time shall be agreed to by you and the
Company or unless postponed in accordance with the provisions of Section 8
hereof). The time at which such payment and delivery are actually made is
hereinafter sometimes called the time of purchase. Certificates for the Firm
Shares shall be delivered to you in definitive form in such names and in such
denominations as you shall specify on the second business day preceding the time
of purchase. For the purpose of expediting the checking of the certificates for
the Firm Shares by you, the Company agrees to make such certificates available
to you for such purpose at least one full business day preceding the time of
purchase.

          Payment of the purchase price for the Additional Shares shall be made
at the additional time of purchase in the same manner and at the same office as
the payment for the Firm Shares.  Certificates for the Additional Shares shall
be delivered to you in definitive form in such names and in such denominations
as you shall specify no later than the second business day preceding the
additional time of purchase.  For the purpose of expediting the checking of the
certificates for the Additional Shares by you, the Company agrees to make such
certificates available to you for such purpose at least one full business day
preceding the additional time of purchase.

          Deliveries of the documents described in Section 6 below with respect
to the purchase of the Shares shall be made at the offices of Winston & Strawn,
35 West Wacker Drive, Chicago, Illinois, 60601 at 9:00 a.m., Chicago time, on
the date of the closing of the purchase of the Firm Shares or the Additional
Shares, as the case may be.

     3. Representations and Warranties. The Company represents and warrants to
each of the Underwriters that:

          (a)  the Company has not received, and has no notice of, any order of
     the preventing or suspending the use of any Preliminary Prospectus, or
     instituting proceedings for that purpose, and each Preliminary Prospectus,
     at the time of filing thereof, conformed in all material respects to the
     requirements of the Act; and when the Registration Statement became or
     becomes effective, the Registration Statement and the Prospectus complied
     or will comply fully in all material respects with the provisions of the
     Act, and the Registration Statement did not or will not contain an untrue
     statement of a material fact or omit to state a material fact required to
     be stated therein or necessary to make the statements therein not
     misleading, and the Prospectus did not or will not contain an untrue
     statement of a material fact or omit to state

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     a material fact required to be stated therein or necessary to make the
     statements therein, in light of the circumstances under which they were
     made, not misleading; provided, however, that the Company makes no warranty
     or representation with respect to any statement contained in the
     Registration Statement or the Prospectus in reliance upon and in conformity
     with information concerning the Underwriters and furnished in writing by or
     on behalf of any Underwriter through you to the Company expressly for use
     in the Registration Statement or the Prospectus; and the Company has not
     distributed directly or indirectly any offering material in connection with
     the offering or sale of the Shares other than the Registration Statement,
     the Preliminary Prospectus, the Prospectus, any amended or corrected
     prospectuses or any other materials, if any, permitted by the Act;

          (b) as of the date of this Agreement and after giving pro forma effect
     to the Reorganization, the Company has authorized and outstanding capital
     stock as set forth under the heading entitled "Pro Forma" in the section of
     the Registration Statement and the Prospectus entitled "Capitalization"
     and, as of the time of purchase, and assuming the receipt and application
     of the net proceeds as described under the section of the Registration
     Statement and the Prospectus entitled "Use of Proceeds," the Company shall
     have an authorized and outstanding capital stock as set forth under the
     heading entitled "Pro Forma As Adjusted" in the section of the Registration
     Statement and the Prospectus entitled "Capitalization"; all of the
     outstanding shares of capital stock are duly and validly authorized and
     issued, fully paid and non-assessable, have been issued in compliance with
     all federal and state securities laws and have not been issued in violation
     of any preemptive right, resale right, right of first refusal or similar
     right;

          (c)  the Company has been duly organized and is validly existing as a
     corporation and is in good standing under the laws of the State of
     Delaware, with full power and authority to own, lease and operate its
     properties and conduct its business as described in the Registration
     Statement;

          (d)  ThermoGen has been duly organized and is validly existing as a
     corporation and is in good standing under the laws of the State of
     Illinois, with full power and authority to own, lease and operate its
     properties and conduct its business as described in the Registration
     Statement;

          (e)  Emerald has been duly organized and is validly existing as a
     corporation and is in good standing under the laws of the State of
     Washington, with full power and authority to own, lease and operate its
     properties and conduct its business as described in the Registration
     Statement;

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          (f)  each of the Company, ThermoGen and Emerald is, and upon
     completion of the Reorganization the Company will be, duly qualified to do
     business as a foreign corporation and is in good standing in each
     jurisdiction in which the ownership or leasing of its properties or the
     conduct of its business requires such qualification, except where the
     failure to so qualify would not have a material adverse effect on the
     business, prospects, properties, financial condition or results of
     operation of, taken as a whole, the Company, ThermoGen and Emerald (a
     "Material Adverse Effect"). Neither ThermoGen nor Emerald has any
     subsidiaries (as defined in the Act); The Company has no subsidiaries (as
     defined in the Act) other than ThermoGen and Emerald; neither the Company,
     ThermoGen nor Emerald owns, directly or indirectly, any shares of stock or
     any other equity or long-term debt securities of any corporation or has any
     equity interest in any firm, partnership, limited liability company, joint
     venture, association or other entity except as set forth in the
     Registration Statement and the Prospectus; complete and correct copies of
     the certificate of incorporation and bylaws of the Company, ThermoGen and
     Emerald and all amendments thereto have been delivered to you, and except
     as set forth in the exhibits to the Registration Statement no changes
     therein will be made subsequent to the date hereof and prior to the time of
     purchase or, if later, the additional time of purchase.

          (g)  neither the Company, ThermoGen nor Emerald is in breach of, or in
     default under (and no event has occurred which with notice, lapse of time,
     or both would result in any breach of, or constitute a default under) its
     respective charter or by-laws or in the performance or observance of any
     obligation, agreement, covenant or condition contained in any indenture,
     mortgage, deed of trust, bank loan or credit agreement or other evidence of
     indebtedness, or any lease, contract or other agreement or instrument to
     which the Company, ThermoGen or Emerald is a party or by which it or any of
     its properties is bound (each, an Obligation Default), which Obligation
     Defaults would individually or in the aggregate have a Material Adverse
     Effect, and the consummation of the Reorganization, the execution, delivery
     and performance of this Agreement, the issuance and sale of the Shares
     contemplated hereby and by the Registration Statement will not conflict
     with, or result in any breach of or constitute a default under (nor
     constitute any event which with notice, lapse of time, or both would result
     in any breach of, or constitute a default under), any provisions of the
     charter or by-laws of the Company, ThermoGen or Emerald or under any
     provision of any license, permit, franchise, indenture, mortgage, deed of
     trust, bank loan or credit agreement or other evidence of indebtedness, or
     any lease, contract or other agreement or instrument to which the Company,
     ThermoGen or Emerald is a party or by which either of them or their
     respective properties may be bound or affected, or under any

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     federal, state, local or foreign law, regulation or rule or any decree,
     judgment or order applicable to the Company, ThermoGen or Emerald;

          (h)  this Agreement has been duly authorized, executed and delivered
     by the Company and is a legal, valid and binding agreement of the Company,
     enforceable in accordance with its terms, except as enforceability may be
     limited by general equitable principles, bankruptcy, insolvency,
     reorganization, moratorium or other laws affecting creditors' rights
     generally;

          (i)  the capital stock of the Company, including the Shares, conforms
     in all material respects to the description thereof contained in the
     Registration Statement and Prospectus, the certificates for the Shares are
     in due and proper form and the holders of the Shares will not be subject to
     personal liability by reason of being such holders;

          (j)  the Shares have been duly and validly authorized and, when issued
     and delivered against payment therefor as provided herein, will be duly and
     validly issued, fully paid and non-assessable;

          (k)  except as set forth in the Registration Statement and the
     Prospectus, no approval, authorization, consent or order of or filing with
     any national, state or local governmental or regulatory commission, board,
     body, authority or agency is required in connection with the execution,
     delivery and performance of this Agreement, the issuance and sale of the
     Shares contemplated hereby and by the Registration Statement, other than
     registration of the Shares under the Act, which has been or will be
     effected by the Company, and any necessary qualification under the
     securities or blue sky laws of the various jurisdictions in which the
     Shares are being offered by the Underwriters or under the rules and
     regulations of the National Association of Securities Dealers, Inc. (NASD);

          (l)  Except as set forth in the Registration Statement and the
     Prospectus: (i) no person has the right, contractual or otherwise, to cause
     the Company to issue to it, or register pursuant to the Act, any shares of
     capital stock or other equity or membership interests of the Company; and
     (ii) no person has any preemptive rights, co-sale rights, rights of first
     refusal or other rights to purchase any shares of Common Stock of the
     Company.

          (m)  KPMG LLP whose report on the financial statements of the Company
     and reports on the financial statements of each of ThermoGen and Emerald
     are filed with the Commission as part of the Registration Statement and
     Prospectus, are independent public accountants as required by the Act;

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          (n)  each of the Company, ThermoGen and Emerald has, and upon
     completion of the Reorganization the Company will have, all necessary
     licenses, permits, franchises, authorizations, consents and approvals
     (each, an "Authorization"), and made all necessary filings required under
     any federal, state, local or foreign law, regulation or rule, and has
     obtained all necessary Authorizations from other persons, in order to
     conduct its business, except where the failure to have any such
     Authorization or to make such filing would not have a Material Adverse
     Effect; neither the Company, ThermoGen nor Emerald is in violation of, or
     in default under, any such license, permit, franchise, authorization,
     consent or approval or any federal, state, local or foreign law, regulation
     or rule or any decree, order or judgment applicable to the Company,
     ThermoGen or Emerald, as the case may be, the effect of which could have a
     Material Adverse Effect;

          (o)  all statutes and regulations and all contracts or other documents
     required to be described in the Registration Statement or the Prospectus or
     to be filed as an exhibit to the Registration Statement have been so
     described in all material respects, or filed as required,;

          (p)  there are no private or governmental actions, suits, claims,
     investigations or proceedings pending, or, to the knowledge of the Company,
     threatened, to which the Company, ThermoGen or Emerald or any of their
     respective officers is subject or of which any of their respective
     properties is subject, whether at law, in equity or before or by any
     federal, state, local or foreign governmental or regulatory commission,
     board, body, authority or agency;

          (q)  the audited financial statements of each of the Company,
     ThermoGen and Emerald included in the Registration Statement and the
     Prospectus (and any amendment or supplement thereto) together with related
     schedules and notes, present fairly the financial position of the Company,
     ThermoGen and Emerald, as the case may be, on the basis stated therein as
     of the respective dates or periods to which they apply; all such financial
     statements have been prepared in conformity with generally accepted
     accounting principles applied on a consistent basis during the periods
     involved except as disclosed therein; the pro forma financial data included
     in the Registration Statement and the Prospectus comply as to form in all
     material respects with the applicable accounting requirements of Regulation
     S-X of the Securities Act, and the pro forma adjustments have been properly
     applied to the historical amounts in the compilation of those statements;
     and the other financial and statistical data set forth in the Registration
     Statement and the Prospectus are, in all material respects, accurately
     presented and prepared on

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     a basis consistent with such financial statements and the books and records
     of the Company, ThermoGen or Emerald, as the case may be;

          (r)  subsequent to the respective dates as of which information is
     given in the Registration Statement and the Prospectus, there has not been
     (i) any material adverse change, or any development involving a prospective
     material adverse change, in the business, prospects, properties, financial
     condition or results of operations of, taken as a whole, the Company,
     ThermoGen and Emerald, (ii) any transaction which is material to, taken as
     a whole, the Company, ThermoGen and Emerald, (iii) the incurrence by the
     Company, ThermoGen or Emerald, of any obligation, direct or contingent,
     which is material to, taken as a whole, the Company, ThermoGen or Emerald,
     (iv) any change in the capital stock or other equity interest or
     outstanding indebtedness of the Company, ThermoGen or Emerald, or (v) any
     dividend or distribution of any kind declared, paid or made on the capital
     stock or other equity interest of the Company, ThermoGen or Emerald;

          (s)  each of the Company, ThermoGen and Emerald has good and
     marketable title to all property (real and personal) described in the
     Prospectus as being owned by it, free and clear of all liens, claims,
     security interests or other encumbrances except such as are described or
     are required to be described in the Registration Statement and the
     Prospectus and except as would not individually or in the aggregate have a
     Material Adverse Effect. All the property described in the Prospectus as
     being held under lease by the Company, ThermoGen or Emerald is held thereby
     under valid, subsisting and, to the knowledge of the Company, ThermoGen or
     Emerald, as the case may be, enforceable leases;

          (t)  each of the Company, ThermoGen and Emerald is insured by insurers
     of recognized financial responsibility against such losses and risks and in
     such amount as are customary in the business in which it is engaged. All
     policies of insurance insuring the Company, ThermoGen or Emerald or any of
     their respective businesses, assets, employees, officers and directors are
     in full force and effect, and the Company, ThermoGen and Emerald are in
     compliance with the terms of such policies in all material respects. There
     are no claims by the Company, ThermoGen or Emerald under any such policy or
     instrument as to which any insurance company is denying liability or
     defending under a reservation of rights clause;

          (u)  neither the Company, ThermoGen nor Emerald has either sent or
     received any notice of termination of any of the contracts or agreements
     referred to or described in, or filed as an exhibit to, the Registration
     Statement,

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     and no such termination has been threatened by the Company, ThermoGen or
     Emerald or any other party to any such contract or agreement;

          (v)  each of the Company, ThermoGen and Emerald maintains a system of
     internal accounting controls sufficient to provide reasonable assurances
     that (i) transactions are executed in accordance with management's general
     or specific authorization; (ii) transactions are recorded as necessary to
     permit preparation of financial statements in conformity with generally
     accepted accounting principles and to maintain accountability for assets;
     (iii) access to assets is permitted only in accordance with management's
     general or specific authorization; and (iv) the recorded accountability for
     assets is compared with existing assets at reasonable intervals and
     appropriate action is taken with respect to any differences;

          (w)  each of the Company, ThermoGen and Emerald has filed all material
     federal, state, local and foreign tax returns and tax forms required to be
     filed. Such returns and forms are complete and correct in all material
     respects, and all taxes shown by such returns or otherwise assessed that
     are due or payable have been paid, except such taxes as are being contested
     in good faith and as to which adequate reserves have been provided. There
     have been no tax deficiencies asserted and, to the knowledge of the
     Company, ThermoGen and Emerald, no tax deficiency might be reasonably
     asserted or threatened against the Company, ThermoGen or Emerald that
     could, individually or in the aggregate, have a Material Adverse Effect;

          (x)  the Company has obtained the agreement (a "Lock-up Agreement") of
     each of its officers and directors and the holders in the aggregate of up
     to 99% of Common Stock and securities convertible into or exchangeable or
     exercisable for Common Stock (including options and warrants) not to sell,
     offer to sell, contract to sell, hypothecate, grant any option to sell or
     otherwise dispose of, directly or indirectly, any shares of Common Stock or
     securities convertible into or exchangeable for Common Stock or warrants or
     other rights to purchase Common Stock for a period of 180 days after the
     date of the Prospectus; and

          (y)  neither the Company, ThermoGen nor Emerald is, and, after giving
     effect to the Reorganization, the offering and sale of the Shares, the
     Company will not be, an "investment company" or a "promoter," "principal
     underwriter" for or an entity "controlled" by an "investment company," as
     such terms are defined in the Investment Company Act of 1940, as amended
     (the "Investment Company Act").

                                       10
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     4.   Certain Covenants. The Company hereby agrees with the Underwriters:

          (a)  to furnish such information as may be reasonably required and
     otherwise to cooperate in qualifying the Shares for offering and sale under
     the securities or blue sky laws of such states as you may reasonably
     designate and to maintain such qualifications in effect so long as
     reasonably required for the distribution of the Shares; provided that the
     Company shall not be required to qualify as a foreign corporation or to
     consent to the service of process under the laws of any such state (except
     service of process with respect to the offering and sale of the Shares);
     and to promptly advise you of the receipt of any notification with respect
     to the suspension of the qualification of the Shares for sale in any
     jurisdiction or the initiation or threatening of any proceeding for such
     purpose;

          (b)  to make available to the Underwriters in New York City, as soon
     as practicable after the Registration Statement becomes effective, and
     thereafter from time to time to furnish to the Underwriters, as many copies
     of the Prospectus (or of the Prospectus as amended or supplemented if the
     Company shall have made any amendments or supplements thereto after the
     effective date of the Registration Statement) as the Underwriters may
     reasonably request for the purposes contemplated by the Act; in case any
     Underwriter is required under applicable law to deliver a prospectus beyond
     the nine-month period referred to in Section 10(a)(3) of the Act in
     connection with the sale of the Shares, the Company will prepare promptly
     upon request, but at the cost of such requesting Underwriter, such
     amendment or amendments to the Registration Statement and such
     prospectuses as may be reasonably necessary to permit compliance with the
     requirements of Section 10(a)(3) of the Act;

          (c)  to advise you promptly, and (if requested by you) to confirm such
     advice in writing, (i) when the Registration Statement has become effective
     and when any post-effective amendment thereto becomes effective and (ii) if
     Rule 430A under the Act is used, when the Prospectus is filed with the
     Commission pursuant to Rule 424(b) under the Act (which the Company agrees
     to file in a timely manner under such Rules);

          (d)  to advise you promptly, and (if requested by you) to confirm such
     advice in writing, of any request by the Commission for amendments or
     supplements to the Registration Statement or Prospectus or for additional
     information with respect thereto, or of notice of institution of
     proceedings for, or the entry of a stop order suspending the effectiveness
     of the Registration Statement and, if the Commission should enter a stop
     order suspending the effectiveness of the Registration Statement, to use
     its best efforts to obtain the

                                       11
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     lifting or removal of such order as soon as possible; to advise you
     promptly of any proposal to amend or supplement the Registration Statement
     or Prospectus and to file no such amendment or supplement to which you
     shall reasonably object in writing;

          (e)  subject to Section 4(n) hereof, to file on a timely basis all
     reports and any definitive proxy or information statement required to be
     filed by the Company with the Commission in order to comply with the
     Exchange Act subsequent to the date of the Prospectus, and to promptly
     notify you of such filing;

          (f)  if necessary or appropriate, to file in a timely fashion a
     registration statement pursuant to Rule 462(b) under the Act;

          (g)  to furnish to you and, upon request, to each of the other
     Underwriters for a period of five years from the date of this Agreement (i)
     copies of any reports or other communications which the Company shall send
     to its stockholders or shall from time to time publish or publicly
     disseminate, (ii) copies of all annual, quarterly and current reports filed
     with the Commission on Forms 10-K, 10-Q and 8-K, or such other similar form
     as may be designated by the Commission, and (iii) such other information as
     you may reasonably request regarding the Company or its subsidiaries, in
     each case as soon as such communications, documents or information becomes
     available;

          (h)  to advise the Underwriters promptly of the happening of any event
     known to the Company within the time during which a Prospectus relating to
     the Shares is required to be delivered under the Act which would require
     the making of any change in the Prospectus then being used so that the
     Prospectus would not include an untrue statement of a material fact or omit
     to state a material fact necessary to make the statements therein, in the
     light of the circumstances under which they are made, not misleading, and,
     during such time, to prepare and furnish promptly to the underwriters, at
     no expense to the Underwriters, such amendments or supplements to such
     Prospectus as may be reasonably necessary to reflect any such change and to
     furnish you a copy of such proposed amendment or supplement before filing
     any such amendment or supplement with the Commission;

          (i)  to make generally available to its security holders, and to
     deliver to you, as soon as practicable an earnings statement (which need
     not be audited) of the Company (which will satisfy the provisions of
     Section 11(a) of the Act) covering a period of twelve months beginning
     after the effective date of the Registration Statement (as defined in Rule
     158(c) of the Act) and ending not later than 15 months thereafter;

                                       12
<PAGE>

          (j)  to furnish to you four conformed copies of the Registration
     Statement, as initially filed with the Commission, and of all amendments
     thereto including all exhibits thereto) and sufficient conformed copies of
     the foregoing (other than exhibits) for distribution of a copy to each of
     the other Underwriters;

          (k)  to furnish to you as early as practicable prior to the time of
     purchase and the additional time of purchase, as the case may be, but not
     later than two business days prior thereto, a copy of the latest available
     quarterly (if available) or monthly unaudited interim consolidated
     financial statements, if any, of the Company, that have been read by the
     Company's independent certified public accountants, as stated in their
     letter to be furnished pursuant to Section 6(b) hereof;

          (l)  to apply the net proceeds from the sale of the Shares in the
     manner set forth under the caption "Use of Proceeds" in the Prospectus;

          (m)  to pay all costs, expenses, fees and taxes (other than any
     transfer taxes and fees and disbursements of counsel for the Underwriters
     except as set forth under Section 5 hereof and subsection (iii), (iv) and
     (vi) below) in connection with (i) the preparation and filing of the
     Registration Statement, each Preliminary Prospectus, the Prospectus, and
     any amendments or supplements thereto, and the printing and furnishing of
     copies of each thereof to the Underwriters and to dealers (including costs
     of mailing and shipment), (ii) the registration, issue, sale and delivery
     of the Shares, (iii) the producing, word processing and/or copying of this
     Agreement, and any closing documents (including compilations thereof), (iv)
     the qualification of the Shares for offering and sale under state laws
     (including the legal fees and filing fees and other disbursements of
     counsel for the Underwriters) and the word processing and/or copying and
     furnishing of copies of any blue sky surveys to the Underwriters, (v) any
     qualification of the Shares for quotation on NASDAQ and any registration
     thereof under the Exchange Act, (vi) any filing for review of the public
     offering of the Shares by the NASD, including the associated fees and
     disbursements of counsel for the Underwriters, and (vii) the performance of
     the Company's other obligations hereunder;

          (n)  to furnish to you, before filing with the Commission subsequent
     to the effective date of the Registration Statement and during the period
     referred to in paragraph (h) above, a copy of any document proposed to be
     filed pursuant to Section 13, 14 or 15(d) of the Exchange Act;

          (o)  not to sell, offer or agree to sell, contract to sell, grant any
     option to sell or otherwise dispose of, directly or indirectly, any shares
     of Common

                                       13
<PAGE>

     Stock or securities convertible into or exchangeable or exercisable for
     Common Stock or warrants or other rights to purchase Common Stock or any
     other shares of the Company that are substantially similar to Common Stock
     or permit the registration under the Act of any shares of Common Stock for
     a period of 180 days after the date hereof (the "Lock-up Period"), without
     the prior written consent of UBSW, except for (i) the registration of the
     Shares and the sales to the Underwriters pursuant to this Agreement, (ii)
     the grant of options to purchase Common Stock disclosed in the Registration
     Statement and the Prospectus, and (iii) the issuance of Common Stock upon
     the exercise of an option or warrant or the conversion of a security
     outstanding on the date hereof;

          (p)  to the extent that the Company is a party thereto, not to amend,
     supplement or otherwise modify, without the consent of UBSW, any agreement
     that prevents any holder of shares of Common Stock or securities
     convertible into or exchangeable or exercisable for Common Stock, from
     selling, offering or agreeing to sell, contracting to sell, granting any
     option to sell or otherwise disposing of, directly or indirectly, during
     the Lock-up Period, such shares or convertible securities; and

          (q)  to use their best efforts to cause the Common Stock to be listed
     for quotation on the National Association of Securities Dealers Automated
     Quotation National Market System ("NASDAQ");

                                       14
<PAGE>

     5.   Reimbursement of Underwriters' Expenses. The Company agrees that if
the Shares are not delivered for any reason other than the termination of this
Agreement pursuant to subsections (ii), (iii) or (iv) of Section 7 hereof or the
default by one or more of the Underwriters in its or their respective
obligations hereunder, the Company shall, in addition to paying the amounts
described in Section 4(m) hereof, reimburse the Underwriters for all of the out-
of-pocket accountable expenses actually incurred by the Underwriters, including
the reasonable fees and disbursements of their counsel.

     6.   Conditions of Underwriters' Obligations. The several obligations of
the Underwriters hereunder are subject to the accuracy of the representations
and warranties on the part of the Company on the date hereof and at the time of
purchase (and the several obligations of the Underwriters at the additional time
of purchase are subject to the accuracy of the representations and warranties on
the part of the Company on the date hereof and at the time of purchase (unless
previously waived) and at the additional time of purchase, as the case may be),
the performance by the Company of their obligations hereunder and to the
following additional conditions precedent:

          (a)  The Company shall furnish to you at the time of purchase and at
     the additional time of purchase, as the case may be, an opinion of Winston
     & Strawn, counsel for the Company, addressed to the Underwriters, and dated
     the time of purchase or the additional time of purchase, as the case may
     be, in form satisfactory to Dewey Ballantine LLP, counsel for the
     Underwriters, stating that:

               (i)  the Company has been duly organized and is validly existing
          as a corporation and is in good standing under the laws of the State
          of Delaware, with full power and authority to own, lease and operate
          its properties and conduct its business as described in the
          Registration Statement and the Prospectus, to execute and deliver this
          Agreement and to issue, sell and deliver the Shares as herein
          contemplated;

               (ii) ThermoGen is validly existing as a corporation and is in
          good standing under the laws of the State of Illinois, with full power
          and authority to own, lease and operate its properties and conduct its
          business as described in the Registration Statement and the
          Prospectus;

             (iii)  Emerald is validly existing as a corporation and is in good
          standing under the laws of the State of Washington, with full power
          and authority to own, lease and operate its properties and conduct its

                                       15
<PAGE>

          business as described in the Registration Statement and the
          Prospectus;

               (iv) each of the Company, ThermoGen and Emerald is duly qualified
          to do business as a foreign corporation and in good standing in each
          jurisdiction in which the ownership or leasing of its properties or
          the conduct of its business requires such qualification, except where
          the failure to so qualify would not have a Material Adverse Effect;

               (v)  this Agreement has been duly authorized, executed and
          delivered by the Company;

               (vi) the Shares have been duly authorized and, when issued and
          delivered to and paid for by the Underwriters, will be validly issued,
          fully paid and non-assessable;

              (vii) the Company has authorized and outstanding shares of capital
          stock as set forth in the Registration Statement and the Prospectus;
          the outstanding shares of capital stock of the Company have been duly
          and validly authorized and issued and are fully paid, nonassessable
          and free of statutory and, to such counsel's knowledge, contractual
          preemptive rights, rights of first refusal and similar rights, except
          as set forth in the Prospectus and the Registration Statement; the
          Shares when issued will be free of statutory and, to such counsel's
          knowledge, contractual preemptive rights; the certificates for the
          Shares are in due and proper form;

             (viii) the capital stock of the Company, including the Shares,
          conforms in all material respects to the description thereof contained
          in the Registration Statement and Prospectus;

               (ix) the Registration Statement and the Prospectus (except as to
          the financial statements and schedules and other financial and
          statistical data contained therein, as to which such counsel need
          express no opinion) comply as to form in all material respects with
          the requirements of the Act;

               (x)  such counsel has been informed by the staff of the
          Commission that the Registration Statement has become effective under
          the Act and, to such counsel's knowledge, no stop order proceedings
          with respect thereto are pending or threatened under the Act and any
          required filing of the Prospectus, and any supplement

                                       16
<PAGE>

          thereto pursuant to Rule 424 under the Act has been made in the manner
          and within the time period required by such Rule 424;

               (xi) except as set forth in the Registration Statement and the
          Prospectus, no approval, authorization, consent or order of or filing
          with any national, state or local governmental or regulatory
          commission, board, body, authority or agency is required which, in
          such counsel's opinion, based on its experience, is normally required
          in transactions in connection with the completion of the
          Reorganization, the execution, delivery and performance of this
          Agreement, the issuance and sale of the Shares and the consummation of
          the transactions contemplated hereby and by the Registration
          Statement, other than registration of the Shares under the Act and
          other than any necessary qualification under the state securities or
          blue sky laws of the various jurisdictions in which the Shares are
          being offered by the Underwriters, as to which such qualification such
          counsel need express no opinion;

              (xii) the completion of the Reorganization, the execution,
          delivery and performance of this Agreement by the Company, the
          issuance and sale of the Shares contemplated hereby and by the
          Registration Statement do not and will not conflict with, or result in
          any breach of, or constitute a default under (nor constitute any event
          which with notice, lapse of time, or both, would result in any breach
          of, or constitute a default under), any provisions of the charter or
          by-laws of the Company, ThermoGen or Emerald, or under any provision
          of any license, permit, franchise, indenture, mortgage, deed of trust,
          bank loan or credit agreement or other evidence of indebtedness, or
          any lease, contract or other agreement or instrument to which the
          Company, ThermoGen or Emerald is a party or by which either of them or
          their respective properties may be bound or affected that is filed as
          an exhibit to the Registration Statement or is otherwise known to such
          counsel, or under any federal, state, local or foreign law, regulation
          or rule or any decree, judgment or order applicable to the Company,
          ThermoGen or Emerald;

            (xiii)  to such counsel's knowledge, neither the Company, ThermoGen
          nor Emerald is in violation of its charter or by-laws, and neither the
          Company, ThermoGen nor Emerald is in breach of nor in default under
          (nor has any event occurred which with notice, lapse of time, or both
          would result in any breach of, or constitute a default under), any
          license, permit, franchise, indenture, mortgage, deed of trust, bank
          loan or credit agreement or other evidence of indebtedness,

                                       17
<PAGE>

          or any lease, contract or other agreement or instrument to which the
          Company, ThermoGen or Emerald is or was a party or by which either of
          them or their respective properties may be bound or affected that is
          filed as an exhibit to the Registration Statement or in violation of
          any U.S. federal, Illinois or Delaware law, regulation or rule or any
          decree, judgment or order applicable to the Company, ThermoGen or
          Emerald which, in such counsel's opinion, based on its experience, is
          normally applicable to transactions contemplated by the Registration
          Statement;

              (xiv) to such counsel's knowledge, there are no contracts,
          licenses, agreements, leases or documents of a character which are
          required to be filed as exhibits to the Registration Statement or to
          be summarized or described in the Prospectus which have not been so
          filed, summarized or described;

               (xv) to such counsel's knowledge, there are no private or
          governmental actions, suits, claims, investigations or proceedings
          pending, threatened or contemplated to which the Company, ThermoGen or
          Emerald is subject or of which any of their respective properties is
          subject, whether at law, in equity or before or by any U.S. federal,
          Illinois or Delaware governmental or regulatory commission, board,
          body, authority or agency;

               (xvi) neither the Company, ThermoGen nor Emerald is, and after
          giving effect to the Reorganization and the offering and sale of the
          Shares, the Company will not be, an "investment company," or a
          "promoter," "principal underwriter" for or an entity controlled by an
          "investment company," as such terms are defined in the Investment
          Company Act;

               (xvii)  the statements in the Registration Statement and
          Prospectus under the headings "Description of Capital Stock",
          "Corporate Reorganization" and "Legal Matters" fairly summarize the
          matters described therein;

          In addition, such counsel shall state that it has participated in
     conferences with officers and other representatives of the Company,
     representatives of the independent public accountants of the Company, and
     representatives of the Underwriters at which the contents of the
     Registration Statement and Prospectus were discussed and, although such
     counsel is not passing upon and does not assume responsibility for the
     accuracy, completeness or fairness of the statements contained in the
     Registration Statement or Prospectus (except as and to the extent stated in
     subparagraphs

                                       18
<PAGE>

     (xvii) above), on the basis of the foregoing nothing has come to the
     attention of such counsel that causes them to believe that the Registration
     Statement or any amendment thereto at the time such Registration Statement
     or amendment became effective contained an untrue statement of a material
     fact or omitted to state a material fact required to be stated therein or
     necessary to make the statements therein not misleading, or that the
     Prospectus or any supplement thereto at the date of such Prospectus or such
     supplement, and at all times up to and including the time of purchase or
     additional time of purchase, as the case may be, contained an untrue
     statement of a material fact or omitted to state a material fact required
     to be stated therein or necessary to make the statements therein, in light
     of the circumstances under which they were made, not misleading (it being
     understood that such counsel need express no opinion with respect to the
     financial statements and schedules and other financial and statistical data
     included in the Registration Statement or Prospectus).

          (b)  You shall have received from KPMG LLP, letters dated,
     respectively, the date of this Agreement, the time of purchase and the
     additional time of purchase, as the case may be, and addressed to the
     Underwriters (with reproduced copies for each of the Underwriters) in the
     forms heretofore approved by Dewey Ballantine LLP, counsel for the
     Underwriters.

          (c)  You shall have received at the time of purchase and at the
     additional time of purchase, as the case may be, the favorable opinion of
     Dewey Ballantine LLP, counsel for the Underwriters, dated the time of
     purchase or the additional time of purchase, as the case may be, with
     respect to the issuance and sale of the Shares by the Company, the
     Registration Statement, the Prospectus (together with any supplement
     thereto) and other related matters as the Underwriters may require.

          (d)  No amendment or supplement to the Registration Statement or
     Prospectus shall be filed prior to the time the Registration Statement
     becomes effective to which you object in writing.

          (e)  The Registration Statement shall become effective, and if Rule
     430A under the Act is used, the Prospectus shall have been filed with the
     Commission pursuant to Rule 424(b) under the Act, at or before 5:30 P.M.,
     New York City time, on the date of this Agreement, unless a later time (but
     not later than 5:30 P.M., New York City time, on the second full business
     day after the date of this Agreement) shall be agreed to by the Company and
     you in

                                       19
<PAGE>

     writing or by telephone, confirmed in writing; provided, however, that the
     Company and you may from time to time agree on a later date.

          (f)  Prior to the time of purchase or the additional time of purchase,
     as the case may be, (i) no stop order with respect to the effectiveness of
     the Registration Statement shall have been issued under the Act or
     proceedings initiated under Section 8(d) or 8(e) of the Act; (ii) the
     Registration Statement and all amendments thereto, or modifications
     thereof, if any, shall not contain an untrue statement of a material fact
     or omit to state a material fact required to be stated therein or necessary
     to make the statements therein not misleading; and (iii) the Prospectus and
     all amendments or supplements thereto, or modifications thereof, if any,
     shall not contain an untrue statement of a material fact or omit to state a
     material fact required to be stated therein or necessary to make the
     statements therein, in the light of the circumstances under which they are
     made, not misleading.

          (g)  Between the time of execution of this Agreement and the time of
     purchase or the additional time of purchase, as the case may be, (i) no
     material and unfavorable change, or any development involving a prospective
     material and adverse change, financial or otherwise (other than as
     specifically identified in the Registration Statement and Prospectus), in
     the business, prospects, properties, financial condition or results of
     operations of, taken as a whole, the Company, ThermoGen and Emerald shall
     occur or become known and (ii) no transaction which is material and
     unfavorable to, taken as a whole, the Company, ThermoGen and Emerald shall
     have been entered into by the Company, ThermoGen or Emerald;

          (h)  The Company will, at the time of purchase or additional time of
     purchase, as the case may be, deliver to you a certificate of its President
     and its Chief Financial Officer to the effect that the representations and
     warranties of the Company as set forth in this Agreement are true and
     correct as of each such date, that the Company has performed such of its
     obligations under this Agreement as are to be performed at or before the
     time of purchase and at or before the additional time of purchase, as the
     case may be, and the conditions set forth in paragraphs (e), (f) and (g) of
     this Section 6 have been met.

          (i)  You shall have received signed Lock-up Agreements, from each of
     the officers and directors of the Company and the holders in the aggregate
     of up to 99% of Common Stock and securities convertible into or
     exchangeable or exercisable for Common Stock (including options and
     warrants), stating that such persons will not sell, offer or agree to sell,
     contract to sell, grant any option to sell or otherwise dispose of,
     directly or indirectly, any shares of Common Stock of the Company or
     securities convertible into or

                                       20
<PAGE>

     exchangeable or exercisable for Common Stock or warrants or other rights to
     purchase Common Stock or any other securities of the Company that are
     substantially similar to the Common Stock for a period of 180 days after
     the date of the Prospectus.

          (j)  The Company, ThermoGen and Emerald shall have furnished to you
     such other documents relating to the Registration Statement and the
     Prospectus as of the time of purchase and the additional time of purchase,
     as the case may be, as you may reasonably request.

          (k)  The Shares shall have been approved for listing for quotation on
     NASDAQ, subject only to notice of issuance at or prior to the time of
     purchase or the additional time of purchase, as the case may be.

          (l)  The Reorganization shall have occurred on the terms set forth and
     as otherwise described in the Registration Statement in all material
     respects.

     7.   Effective Date of Agreement; Termination. This Agreement shall become
effective (i) if Rule 430A under the Act is not used, when the Registration
Statement shall become effective under the Act, or (ii) if Rule 430A under the
Act is used, when the parties hereto have executed and delivered this Agreement.

          The obligations of the several Underwriters hereunder shall be subject
to termination in the absolute discretion of you, (i) if, since the time of
execution of this Agreement or the respective dates as of which information is
given in the Registration Statement and Prospectus, there has been any material
adverse and unfavorable change, or any development involving a prospective
material adverse change, financial or otherwise (other than as specifically
identified in the Registration Statement and Prospectus), in the business,
prospects, properties, condition or results of operations of, taken as a whole,
the Company, ThermoGen and Emerald which would, in your judgment, make it
impracticable to market the Shares, or, (ii) if, at any time prior to the time
of purchase or, with respect to the purchase of any Additional Shares, the
additional time of purchase, as the case may be, trading in securities on the
New York Stock Exchange, the American Stock Exchange or the Nasdaq National
Market shall have been suspended or limitations or minimum prices shall have
been established on the New York Stock Exchange, the American Stock Exchange or
the Nasdaq National Market, or (iii) if a banking moratorium shall have been
declared either by the United States or New York State authorities, or (iv) if
the United States shall have declared war in accordance with its constitutional
processes or there shall have occurred any material outbreak or escalation of
hostilities or other national or international calamity or crisis of such
magnitude in its effect on the

                                       21
<PAGE>

financial markets of the United States as, in your judgment, to make it
impracticable to market the Shares.

          If you elects to terminate this Agreement as provided in this Section
7, the Company and each other Underwriter shall be notified promptly by letter
or telegram.

          Notwithstanding anything in this Agreement to the contrary, the
obligations of the Company under Sections 4(m), 5 and 9 hereof and the
obligations of the Underwriters under Sections 8 and 9 hereof shall survive the
termination of this Agreement.

     8.   Increase in Underwriters' Commitments. Subject to the satisfaction of
the conditions set forth in Sections 6, if any Underwriter shall default in its
obligation to take up and pay for the Firm Shares to be purchased by it
hereunder (otherwise than for a reason sufficient to justify the termination of
this Agreement under the provisions of Section 7 hereof) and if the number of
Firm Shares which all Underwriters so defaulting shall have agreed but failed to
take up and pay for does not exceed 10% of the total number of Firm Shares, the
non-defaulting Underwriters shall take up and pay for (in addition to the
aggregate number of Firm Shares they are obligated to purchase pursuant to
Section 1 hereof) the number of Firm Shares agreed to be purchased by all such
defaulting Underwriters, as hereinafter provided. Such Shares shall be taken up
and paid for by such non-defaulting Underwriter or Underwriters in such amount
or amounts as you may designate with the consent of each Underwriter so
designated or, in the event no such designation is made, such Shares shall be
taken up and paid for by all non-defaulting Underwriters pro rata in proportion
to the aggregate number of Firm Shares set opposite the names of such non-
defaulting Underwriters in Schedule A.

          If a new Underwriter or Underwriters are substituted by the
Underwriters or by the Company for a defaulting Underwriter or Underwriters in
accordance with the foregoing provision, the Company or you shall have the right
to postpone the time of purchase for a period not exceeding five business days
in order that any necessary changes in the Registration Statement and Prospectus
and other documents may be effected.

          The term Underwriter as used in this Agreement shall refer to and
include any Underwriter substituted under this Section 8 with like effect as if
such substituted Underwriter had originally been named in Schedule A.

          If the aggregate number of Shares which the defaulting Underwriter or
Underwriters agreed to purchase exceeds 10% of the total number of Shares which
all Underwriters agreed to purchase hereunder, and if neither the non-defaulting

                                       22
<PAGE>

Underwriters nor the Company shall make arrangements within the five business
day period stated above for the purchase of all the Shares which the defaulting
Underwriter or Underwriters agreed to purchase hereunder, this Agreement shall
be terminated without further act or deed and without any liability on the part
of the Company to any non-defaulting Underwriter and without any liability on
the part of any non-defaulting Underwriter to the Company.  Nothing in this
paragraph, and no action taken hereunder, shall relieve any defaulting
Underwriter from liability in respect of any default of such Underwriter under
this Agreement.

     9.   Indemnity and Contribution.

          (a)  The Company agrees to indemnify, defend and hold harmless each
Underwriter, its partners, directors and officers, and any person who controls
any Underwriter within the meaning of Section 15 of the Act or Section 20 of the
Exchange Act, and the successors and assigns of all of the foregoing persons
from and against any loss, damage, expense, liability or claim (including the
reasonable cost of investigation) which, jointly or severally, any such
Underwriter or any such person may incur under the Act, the Exchange Act, the
common law or otherwise, insofar as such loss, damage, expense, liability or
claim arises out of or is based upon (i) any untrue statement or alleged untrue
statement of a material fact contained in the Registration Statement (or in the
Registration Statement as amended by any post-effective amendment thereof by the
Company) or in a Prospectus (the term Prospectus for the purpose of this Section
9 being deemed to include any Preliminary Prospectus, the Prospectus and the
Prospectus as amended or supplemented by the Company), or arises out of or is
based upon any omission or alleged omission to state a material fact required to
be stated in either such Registration Statement or Prospectus or necessary to
make the statements made therein not misleading, except insofar as any such
loss, damage, expense, liability or claim arises out of or is based upon any
untrue statement or alleged untrue statement of a material fact contained in and
in conformity with information furnished in writing by or on behalf of any
Underwriter through you to the Company expressly for use with reference to such
Underwriter in such Registration Statement or such Prospectus or arises out of
or is based upon any omission or alleged omission to state a material fact in
connection with such information required to be stated in such Registration
Statement or such Prospectus or necessary to make such information not
misleading or (ii) any untrue statement or alleged untrue statement made by the
Company in Section 3 of this Agreement or the failure by the Company to perform
when and as required any agreement or covenant contained herein (iii) any untrue
statement or alleged untrue statement of any material fact contained in any
audio or visual materials provided by the Company or based upon written
information furnished by or on behalf of the Company including, without
limitation, slides, videos, films, tape recordings, used in connection with the
marketing of the Shares, or (iv) the Directed

                                       23
<PAGE>

Share Program, provided that, the Company shall not be responsible for any loss,
damage, expense, liability, or claim that is finally judicially determined to
have resulted from the bad faith or gross negligence of the Underwriters in
conducting the Directed Share Program, and provided further that, the indemnity
agreement contained in clause (i) of this subsection (a) with respect to any
Preliminary Prospectus or amended Preliminary Prospectus shall not inure to the
benefit of any Underwriter from whom the person asserting any such loss, damage,
expense, liability or claim purchased the Shares which is the subject thereof if
the Prospectus corrected any such alleged untrue statement or omission and if
such Underwriter failed to send or give a copy of the Prospectus to such person
at or prior to the written confirmation of the sale of such Shares to such
person, unless the failure is the result of noncompliance by the Company with
Section 4(g) hereof.

          If any action, suit or proceeding (together, a "Proceeding") is
brought against an Underwriter or any such person in respect of which indemnity
may be sought against the Company pursuant to the foregoing paragraph, such
Underwriter or such person shall promptly notify the Company in writing of the
institution of such Proceeding and the Company shall assume the defense of such
Proceeding, including the employment of counsel reasonably satisfactory to such
indemnified party and payment of all fees and expenses; provided, however, that
the omission to so notify the Company shall not relieve the Company from any
liability which the Company may have to any Underwriter or any such person or
otherwise.  Such Underwriter or such person shall have the right to employ its
or their own counsel in any such case, but the fees and expenses of such counsel
shall be at the expense of such Underwriter or of such person unless the
employment of such counsel shall have been authorized in writing by the Company
in connection with the defense of such Proceeding or the Company shall not have,
within a reasonable period of time in light of the circumstances, employed
counsel to defend such Proceeding or such indemnified party or parties shall
have reasonably concluded that there may be defenses available to it or them
which are different from, additional to or in conflict with those available to
the Company (in which case the Company shall not have the right to direct the
defense of such Proceeding on behalf of the indemnified party or parties), in
any of which events such fees and expenses shall be borne by the Company and
paid as incurred (it being understood, however, that the Company shall not be
liable for the expenses of more than one separate counsel (in addition to any
local counsel) in any one Proceeding or series of related Proceedings in the
same jurisdiction representing the indemnified parties who are parties to such
Proceeding).  The Company shall not be liable for any settlement of any
Proceeding effected without the written consent of the Company but if settled
with the written consent of the Company, the Company agree to indemnify and hold
harmless any Underwriter and any such person from and against any loss or
liability by reason of such settlement.  Notwithstanding the foregoing sentence,
if at any time an

                                       24
<PAGE>

indemnified party shall have requested that an indemnifying party reimburse the
indemnified party for fees and expenses of counsel as contemplated by the second
sentence of this paragraph, then the indemnifying party agrees that it shall be
liable for any settlement of any Proceeding effected without the Company's
written consent if (i) such settlement is entered into more than 60 business
days after receipt by the indemnifying party of the aforesaid request, (ii) such
indemnifying party shall not have reimbursed the indemnified party in accordance
with such request prior to the date of such settlement and (iii) such
indemnified party shall have given the indemnifying party at least 30 days'
prior notice of its intention to settle. No indemnifying party shall, without
the prior written consent of the indemnified party, effect any settlement of any
pending or threatened Proceeding in respect of which any indemnified party is or
could have been a party and indemnity could have been sought hereunder by such
indemnified party, unless such settlement includes an unconditional release of
such indemnified party from all liability on claims that are the subject matter
of such Proceeding and does not include an admission of fault, culpability or a
failure to act, by or on behalf of such indemnified party.

          (b)  In connection with the offer and sale of the Reserved Shares, the
Company agrees to pay UBSW, at its request, the full purchase price of all
Reserved Shares which were subject to a properly confirmed agreement to purchase
and for which any Directed Share Participant failed to pay therefor and accept
delivery thereof.

          (c)  Each Underwriter severally agrees to indemnify, defend and hold
harmless the Company, its respective directors and officers, and any person who
controls the Company within the meaning of Section 15 of the Act or Section 20
of the Exchange Act, and the successors and assigns of all of the foregoing
persons from and against any loss, damage, expense, liability or claim
(including the reasonable cost of investigation) which the Company, or any such
person may incur under the Act, the Exchange Act, the common law or otherwise,
insofar as such loss, damage, expense, liability or claim arises out of or is
based upon any untrue statement or alleged untrue statement of a material fact
contained in and in conformity with information furnished in writing by or on
behalf of such Underwriter through you to the Company expressly for use with
reference to such Underwriter in the Registration Statement (or in the
Registration Statement as amended by any post-effective amendment thereof by the
Company) or in a Prospectus, or arises out of or is based upon any omission or
alleged omission to state a material fact in connection with such information
required to be stated in such Registration Statement or such Prospectus or
necessary to make such information not misleading.

                                       25
<PAGE>

          If any Proceeding is brought against the Company, or any such person
in respect of which indemnity may be sought against any Underwriter pursuant to
the foregoing paragraph, the Company or such person shall promptly notify such
Underwriter in writing of the institution of such Proceeding and such
Underwriter shall assume the defense of such Proceeding, including the
employment of counsel reasonably satisfactory to such indemnified party and
payment of all fees and expenses; provided, however, that the omission to so
notify such Underwriter shall not relieve such Underwriter from any liability
which such Underwriter may have to the Company or any such person or otherwise.
The Company or such person shall have the right to employ its own counsel in any
such case, but the fees and expenses of such counsel shall be at the expense of
the Company or such person unless the employment of such counsel shall have been
authorized in writing by such Underwriter in connection with the defense of such
Proceeding or such Underwriter shall not have, within a reasonable period of
time in light of the circumstances, employed counsel to have charge of the
defense of such Proceeding or such indemnified party or parties shall have
reasonably concluded that there may be defenses available to it or them which
are different from or additional to or in conflict with those available to such
Underwriter (in which case such Underwriter shall not have the right to direct
the defense of such Proceeding on behalf of the indemnified party or parties,
but such Underwriter may employ counsel and participate in the defense thereof
but the fees and expenses of such counsel shall be at the expense of such
Underwriter), in any of which events such fees and expenses shall be borne by
such Underwriter and paid as incurred (it being understood, however, that such
Underwriter shall not be liable for the expenses of more than one separate
counsel (in addition to any local counsel) in any one Proceeding or series of
related Proceedings in the same jurisdiction representing the indemnified
parties who are parties to such Proceeding). No Underwriter shall be liable for
any settlement of any such Proceeding effected without the written consent of
such Underwriter but if settled with the written consent of such Underwriter,
such Underwriter agrees to indemnify and hold harmless the Company and any such
person from and against any loss or liability by reason of such settlement.
Notwithstanding the foregoing sentence, if at any time an indemnified party
shall have requested an indemnifying party to reimburse the indemnified party
for fees and expenses of counsel as contemplated by the second sentence of this
paragraph, then the indemnifying party agrees that it shall be liable for any
settlement of any Proceeding effected without its written consent if (i) such
settlement is entered into more than 60 business days after receipt by such
indemnifying party of the aforesaid request, (ii) such indemnifying party shall
not have reimbursed the indemnified party in accordance with such request prior
to the date of such settlement and (iii) such indemnified party shall have given
the indemnifying party at least 30 days' prior notice of its intention to
settle. No indemnifying party shall, without the prior written consent of the
indemnified party, effect any settlement of any pending or threatened Proceeding
in respect of which

                                       26
<PAGE>

any indemnified party is or could have been a party and indemnity could have
been sought hereunder by such indemnified party, unless such settlement includes
an unconditional release of such indemnified party from all liability on claims
that are the subject matter of such Proceeding.

          (d)  If the indemnification provided for in this Section 9 is
unavailable to an indemnified party under subsections (a) and (b) of this
Section 9 in respect of any losses, damages, expenses, liabilities or claims
referred to therein, then each applicable indemnifying party, in lieu of
indemnifying such indemnified party, shall contribute to the amount paid or
payable by such indemnified party as a result of such losses, damages, expenses,
liabilities or claims (i) in such proportion as is appropriate to reflect the
relative benefits received by the Company on the one hand and the Underwriters
on the other hand from the offering of the Shares or (ii) if the allocation
provided by clause (i) above is not permitted by applicable law, in such
proportion as is appropriate to reflect not only the relative benefits referred
to in clause (i) above but also the relative fault of the Company on the one
hand and of the Underwriters on the other in connection with the statements or
omissions which resulted in such losses, damages, expenses, liabilities or
claims, as well as any other relevant equitable considerations. The relative
benefits received by the Company on the one hand and the Underwriters on the
other shall be deemed to be in the same respective proportions as the total
proceeds from the offering (net of underwriting discounts and commissions but
before deducting expenses) received by the Company and the total underwriting
discounts and commissions received by the Underwriters, bear to the aggregate
public offering price of the Shares. The relative fault of the Company on the
one hand and of the Underwriters on the other shall be determined by reference
to, among other things, whether the untrue statement or alleged untrue statement
of a material fact or omission or alleged omission relates to information
supplied by the Company or by the Underwriters and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission. The amount paid or payable by a party as a result of the
losses, damages, expenses, liabilities and claims referred to in this subsection
shall be deemed to include any legal or other fees or expenses reasonably
incurred by such party in connection with investigating, preparing to defend or
defending any Proceeding.

          (e)  The Company and the Underwriters agree that it would not be just
and equitable if contribution pursuant to this Section 9 were determined by pro
rata allocation (even if the Underwriters were treated as one entity for such
purpose) or by any other method of allocation that does not take account of the
equitable considerations referred to in subsection (c) above. Notwithstanding
the provisions of this Section 9, in no case shall any Underwriter be required
to contribute any amount in excess of the amount by which the total price at
which the Shares underwritten by

                                       27
<PAGE>

such Underwriter and distributed to the public were offered to the public
exceeds the amount of any damage which such Underwriter has otherwise been
required to pay by reason of such untrue statement or alleged untrue statement
or omission or alleged omission. No person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Act) shall be
entitled to contribution from any person who was not guilty of such fraudulent
misrepresentation. The Underwriters' obligations to contribute pursuant to this
Section 9 are several in proportion to their respective underwriting commitments
and not joint.

          (f)  The indemnity and contribution agreements contained in this
Section 9 and the covenants, warranties and representations of the Company
contained in this Agreement shall remain in full force and effect regardless of
any investigation made by or on behalf of any Underwriter, its partners,
directors or officers or any person (including each partner, officer or director
of such person) who controls any Underwriter within the meaning of Section 15 of
the Act or Section 20 of the Exchange Act, or by or on behalf of the Company,
its respective directors or officers or any person who controls the Company
within the meaning of Section 15 of the Act or Section 20 of the Exchange Act,
and shall survive any termination of this Agreement or the issuance and delivery
of the Shares. The Company and each Underwriter agree promptly to notify each
other of the commencement of any Proceeding against it and, in the case of the
Company, against any of the Company's officers or directors in connection with
the issuance and sale of the Shares, or in connection with the Registration
Statement or Prospectus.

     10.  Notices. Except as otherwise herein provided, all statements,
requests, notices and agreements shall be in writing or by telegram and, if to
the Underwriters, shall be sufficient in all respects if delivered or sent to
UBS Warburg LLC, 299 Park Avenue, New York, N.Y. 10171-0026, Attention:
Syndicate Department and, if to the Company, shall be sufficient in all respects
if delivered or sent to the Company at the offices of the Company at 12305 South
New Avenue, Lemont, Illinois, 60439, Attention: Michael T. Flavin, Chief
Executive Officer.

     11.  Governing Law; Construction. This Agreement and any claim,
counterclaim or dispute of any kind or nature whatsoever arising out of or in
any way relating to this Agreement ("Claim"), directly or indirectly, shall be
governed by, and construed in accordance with, the laws of the State of New
York. The Section headings in this Agreement have been inserted as a matter of
convenience of reference and are not a part of this Agreement.

     12.  Submission to Jurisdiction. Except as set forth below, no Claim may be
commenced, prosecuted or continued in any court other than the courts of the
State of New York located in the City and County of New York or in the United
States District Court for the Southern District of New York, which courts shall
have

                                       28
<PAGE>

jurisdiction over the adjudication of such matters, and the Company consents to
the jurisdiction of such courts and personal service with respect thereto. The
Company hereby consents to personal jurisdiction, service and venue in any court
in which any Claim arising out of or in any way relating to this Agreement is
brought by any third party against UBSW or any indemnified party. Each of UBSW
and the Company (on its behalf and, to the extent permitted by applicable law,
on behalf of its stockholders and affiliates) waives all right to trial by jury
in any action, proceeding or counterclaim (whether based upon contract, tort or
otherwise) in any way arising out of or relating to this Agreement. The Company
agrees that a final judgment in any such action, proceeding or counterclaim
brought in any such court shall be conclusive and binding upon the Company and
may be enforced in any other courts in the jurisdiction of which the Company is
or may be subject, by suit upon such judgment.

     13.  Parties at Interest. The Agreement herein set forth has been and is
made solely for the benefit of the Underwriters, and the Company and to the
extent provided in Section 9 hereof the controlling persons, directors and
officers referred to in such section, and their respective successors, assigns,
heirs, personal representatives and executors and administrators. No other
person, partnership, association or corporation (including a purchaser, as such
purchaser, from any of the Underwriters) shall acquire or have any right under
or by virtue of this Agreement.

     14.  Counterparts. This Agreement may be signed by the parties in one or
more counterparts which together shall constitute one and the same agreement
among the parties.

     15.  Successors and Assigns. This Agreement shall be binding upon the
Underwriters, and the Company and their successors and assigns and any successor
or assign of any substantial portion of the Company's, and any of the
Underwriters' respective businesses and/or assets.

     16.  Miscellaneous. UBSW, an indirect, wholly owned subsidiary of UBS AG,
is not a bank and is separate from any affiliated bank, including any U.S.
branch or agency of UBSW. Because UBSW is a separately incorporated entity, it
is solely responsible for its own contractual obligations and commitments,
including obligations with respect to sales and purchases of securities.
Securities sold, offered or recommended by UBSW are not deposits, are not
insured by the Federal Deposit Insurance Corporation, are not guaranteed by a
branch or agency, and are not otherwise an obligation or responsibility of a
branch or agency.

          A lending affiliate of UBSW may have lending relationships with
issuers of securities underwritten or privately placed by UBSW.  To the extent
required under the securities laws, prospectuses and other disclosure documents
for securities underwritten or privately placed by UBSW will disclose the
existence of any such

                                       29
<PAGE>

lending relationships and whether the proceeds of the issue will be used to
repay debts owed to affiliates of UBSW.

                                       30
<PAGE>

          If the foregoing correctly sets forth the understanding among the
Company and the Underwriters, please so indicate in the space provided below for
the purpose, whereupon this letter and your acceptance shall constitute a
binding agreement among the Company and the Underwriters, severally.

                              Very truly yours,

                              MEDICHEM LIFE SCIENCES, INC.

                              By:
                                 ----------------------------------
                                  Name:
                                  Title:


Accepted and agreed to as of the
 date first above written, on behalf of
 themselves and the other several Underwriters
 named in Schedule A

UBS WARBURG LLC
CHASE SECURITIES, INC.
WILLIAM BLAIR & COMPANY, L.L.C.


--------------------------------

By:  UBS WARBURG LLC

By:
   -------------------------
   Title:  Managing Director

By:
   -------------------------
   Title:  Director

                                       31
<PAGE>

                                   SCHEDULE A

                                                                      Number of
Underwriter                                                         Firm Shares
-----------                                                         -----------
UBS WARBURG LLC....................................................
CHASE SECURITIES, INC..............................................
WILLIAM BLAIR & COMPANY, L.L.C.....................................
 ...................................................................
 ...................................................................
 ...................................................................
 ...................................................................
                         Total..................................... ============

                                       32


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