XENOGEN CORP
S-1/A, EX-1.1, 2000-12-29
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>

                              Xenogen Corporation


                               7,000,000 Shares


                                 Common Stock
                              ($0.001 Par Value)



                            UNDERWRITING AGREEMENT



________ __, 2001
<PAGE>

                            UNDERWRITING AGREEMENT

                                                               ________ __, 2001


UBS Warburg LLC
CIBC World Markets Corp.
Dain Rauscher Incorporated
     As representatives of the several Underwriters
     named in Schedule A hereto
              ----------

c/o UBS Warburg LLC
299 Park Avenue
New York, New York  10171-0026


Ladies and Gentlemen:

          Xenogen Corporation, a Delaware corporation (the "Company"), proposes
                                                            -------
to issue and sell to the Underwriters named in Schedule A annexed hereto (the
                                               ----------
"Underwriters") an aggregate of 7,000,000 shares (the "Firm Shares") of common
-------------                                          -----------
stock, $0.001 par value per share, of the Company (the "Common Stock").  In
                                                        ------------
addition, solely for the purpose of covering over-allotments, the Company
proposes to grant to the Underwriters the option to purchase from the Company up
to an additional 1,050,000 shares of Common Stock (the "Additional Shares").
                                                        -----------------
The Firm Shares and the Additional Shares are hereinafter collectively sometimes
referred to as the "Shares."  The Shares are described in the Prospectus which
                    ------
is referred to below.

          The Company hereby acknowledges that in connection with the proposed
offering of the Shares, it has requested UBS Warburg LLC ("UBSW") to administer
                                                           ----
a directed share program (the "Directed Share Program") under which up to
                               ----------------------
350,000 Firm Shares, or 5% of the Firm Shares, to be purchased by you (the
"Reserved Shares") shall be reserved for sale by you at the initial public
----------------
offering price to the Company's officers, directors, employees, and consultants
and others having a relationship with the Company (the "Directed Share
                                                        --------------
Participants") as part of the distribution of the Shares by the Underwriters,
------------
subject to the terms of this Agreement, the applicable rules, regulations and
interpretations of the National Association of Securities Dealers, Inc. ("NASD")
                                                                          ----
and all other applicable laws, rules and regulations.  The number of Shares
available for sale to the general public will be reduced to the extent that
Directed Share Participants purchase Reserved Shares.  You may offer any
Reserved Shares not purchased by Directed Share Participants to the general
public on the same basis as the other Shares being issued and sold hereunder.
The Company has supplied UBSW with the names, addresses and telephone numbers of
the individuals or other entities which the Company has designated to be
participants in the Directed Share Program.  It is understood that any number of
those designated to participate in the Directed Share Program may decline to do
so.

          The Company has filed, in accordance with the provisions of the
Securities Act of 1933, as amended, and the rules and regulations thereunder
(collectively, the "Act"), with the
                    ---
<PAGE>

Securities and Exchange Commission (the "Commission") a registration statement
                                         ----------
on Form S-1 (File No. 333-47030) including a prospectus, relating to the Shares.
The Company has furnished to you, for use by the Underwriters and by dealers,
copies of one or more preliminary prospectuses (each thereof being herein called
 a "Preliminary Prospectus") relating to the Shares.  Except where the context
    ----------------------
therwise requires, the registration statement, as amended when it becomes
effective, including all documents filed as a part thereof, and including any
information contained in a prospectus subsequently filed with the Commission
pursuant to Rule 424(b) under the Act and deemed to be part of the registration
statement at the time of effectiveness pursuant to Rule 430(A) under the Act,
and also including any registration statement filed pursuant to Rule 462(b)
under the Act with respect to the offering contemplated by the Registration
Statement, is herein called the "Registration Statement," and the prospectus, in
                                 ------------ ---------
the form filed by the Company with the Commission pursuant to Rule 424(b) under
the Act on or before the second business day after the date hereof (or such
earlier time as may be required under the Act) or, if no such filing is
required, the form of final prospectus included in the Registration Statement at
the time the Registration Statement became effective, is herein called the
"Prospectus."
 ----------

          The Company and the Underwriters agree as follows:

          1.  Sale and Purchase.  Upon the basis of the representations and
              -----------------
warranties and subject to the terms and conditions herein set forth, the Company
agrees to sell to the respective Underwriters and each of the Underwriters,
severally and not jointly, agrees to purchase from the Company the aggregate
number of Firm Shares set forth opposite the name of such Underwriter in
Schedule A attached hereto, in each case at a purchase price of $____ per Share.
----------
The Company is advised by you that the Underwriters intend (i) to make a public
offering of their respective portions of the Firm Shares as soon after the
effective date of the Registration Statement as in your judgment is advisable
and (ii) initially to offer the Firm Shares upon the terms set forth in the
Prospectus. You may from time to time increase or decrease the public offering
price after the initial public offering to such extent as you may determine.

          In addition, the Company hereby grants to the several Underwriters the
option to purchase, and upon the basis of the representations and warranties and
subject to the terms and conditions herein set forth, the Underwriters shall
have the right to purchase, severally and not jointly, from the Company, ratably
in accordance with the number of Firm Shares to be purchased by each of them,
all or a portion of the Additional Shares as may be necessary to cover over-
allotments made in connection with the offering of the Firm Shares, at the same
purchase price per share to be paid by the Underwriters to the Company for the
Firm Shares.  This option may be exercised by you on behalf of the several
Underwriters at any time and from time to time on or before the thirtieth (30th)
day following the date hereof, by written notice to the Company.  Such notice
shall set forth the aggregate number of Additional Shares as to which the option
is being exercised and the date and time when the Additional Shares are to be
delivered (such date and time being herein referred to as the "additional time
                                                               ---------------
of purchase"); provided, however, that the additional time of purchase shall not
-----------    --------  -------
not be earlier than the time of

                                       2
<PAGE>

purchase (as defined below) nor earlier than the second business day/1/ after
the date on which the option shall have been exercised nor later than the tenth
business day after the date on which the option shall have been exercised. The
number of Additional Shares to be sold to each Underwriter shall be the number
which bears the same proportion to the aggregate number of Additional Shares
being purchased as the number of Firm Shares set forth opposite the name of such
Underwriter on Schedule A hereto bears to the total number of Firm Shares
               ----------
(subject, in each case, to such adjustment as you may determine to eliminate
fractional shares).

          2.   Payment and Delivery.  Payment of the purchase price for the
               --------------------
Firm Shares shall be made to the Company by Federal Funds wire transfer against
delivery of the certificates for the Firm Shares to you through the facilities
of the Depository Trust Company ("DTC") for the respective accounts of the
                                  ---
Underwriters.  Such payment and delivery shall be made at 10:00 A.M., New York
City time, on _________ __, 2001 (unless another time shall be agreed to by you
and the Company or unless postponed in accordance with the provisions of Section
9 hereof).  The time at which such payment and delivery are actually made is
hereinafter sometimes called the "time of purchase."  Certificates for the Firm
                                  ----------------
Shares shall be delivered to you in definitive form in such names and in such
denominations as you shall specify on the second business day preceding the time
of purchase.  For the purpose of expediting the checking of the certificates for
the Firm Shares by you, the Company agrees to make such certificates available
to you for such purpose at least one full business day preceding the time of
purchase.

          Payment of the purchase price for the Additional Shares shall be made
at the additional time of purchase in the same manner and at the same office as
the payment for the Firm Shares.  Certificates for the Additional Shares shall
be delivered to you in definitive form in such names and in such denominations
as you shall specify no later than the second business day preceding the
additional time of purchase.  For the purpose of expediting the checking of the
certificates for the Additional Shares by you, the Company agrees to make such
certificates available to you for such purpose at least one full business day
preceding the additional time of purchase.

          Deliveries of the documents described in Section 7 below with respect
to the purchase of the Shares shall be made at the offices of Dewey Ballantine
LLP, 1301 Avenue of the Americas, New York, New York at 9:00 A.M., New York City
time, on the date of the closing of the purchase of the Firm Shares or the
Additional Shares, as the case may be.

          3.   Representations and Warranties.  The Company represents and
               ------------------------------
warrants to each of the Underwriters that:

          (a)  This Agreement has been duly authorized, executed and delivered
     by the Company and is a legal, valid and binding agreement of the Company,
     enforceable against the Company in accordance with its terms.


__________________________
     /1/ As used herein "business day" shall mean a day on which th New York
Stock Exchange is open for trading.

                                       3
<PAGE>

          (b)  The Shares have been duly and validly authorized and, when issued
     and delivered against payment therefor as provided herein, will be duly and
     validly issued, fully paid and non-assessable. The holders of the Shares
     will not be subject to personal liability by reason of being such holders.
     The certificates for the Shares are in due and proper form and conform in
     all material respects to the requirements of the Delaware General
     Corporation Law.

          (c)  No approval, authorization, consent or order of or filing with
     any national, state or local governmental or regulatory commission, board,
     body, authority or agency is required in connection with the execution,
     delivery and performance by the Company of this Agreement, the issuance and
     sale of the Shares contemplated hereby and by the Registration Statement,
     other than registration of the Shares under the Act and under the
     Securities Exchange Act of 1934, as amended, and the rules and regulations
     thereunder (collectively, the "Exchange Act"), which have been or will be
                                    ------------
     effected by the Company, and any necessary qualification under the
     securities or blue sky laws of the various jurisdictions in which the
     Shares are being offered by the Underwriters or under the rules and
     regulations of the NASD.

          (d)  The Company has not received, and has no notice of, any order of
     the Commission preventing or suspending the use of any Preliminary
     Prospectus, or instituting proceedings for that purpose, and each
     Preliminary Prospectus, at the time of filing thereof, conformed in all
     material respects to the requirements of the Act. When the Registration
     Statement became or becomes effective, the Registration Statement and the
     Prospectus complied or will comply in all material respects with the
     provisions of the Act, and the Registration Statement did not or will not
     contain an untrue statement of a material fact or omit to state a material
     fact required to be stated therein or necessary to make the statements
     therein not misleading, and the Prospectus did not or will not contain an
     untrue statement of a material fact or omit to state a material fact
     required to be stated therein or necessary to make the statements therein,
     in light of the circumstances under which they were made, not misleading
     and the Prospectus, any Preliminary Prospectus and any supplement thereto
     or prospectus wrapper prepared in connection therewith, at their respective
     times of issuance and at the time of closing, complied and will comply in
     all material respects with any applicable laws or regulations of
     jurisdictions in which the Prospectus and such preliminary prospectus, as
     amended or supplemented, if applicable, are distributed in connection with
     the offer and sale of the Shares, provided, however, that the Company makes
                                       --------  -------
     no representation or warranty with respect to any statement contained in
     the Registration Statement or the Prospectus in reliance upon and in
     conformity with information concerning the Underwriters and furnished in
     writing by or on behalf of any Underwriter through you to the Company
     expressly for use in the Registration Statement or the Prospectus.  Neither
     the Company nor, to the Company's knowledge, any of its affiliates (as
     defined in the Act) has distributed directly or indirectly any offering
     material in connection with the offering or sale of the Shares other than
     the Registration Statement, the Preliminary Prospectus, the Prospectus or
     any other materials, if any, permitted by the Act.

          (e)  The audited financial statements of the Company included in the
     Registration Statement and the Prospectus present fairly the financial
     position and results of

                                       4
<PAGE>

     operations of the Company as of the dates and for the periods indicated;
     such financial statements have been prepared in conformity with generally
     accepted accounting principles applied on a consistent basis during the
     periods involved; the pro forma financial data included in the Registration
     Statement and the Prospectus comply as to form in all material respects
     with the applicable accounting requirements of Regulation S-X of the
     Securities Act, and the pro forma adjustments have been properly applied to
     the historical amounts in the compilation of those statements; the other
     financial and statistical data set forth in the Registration Statement and
     the Prospectus are accurately presented and prepared on a basis consistent
     with such financial statements and the books and records of the Company;
     and there are no financial statements (historical or pro forma) that are
     required to be included in the Registration Statement and the Prospectus
     that are not included as required.

          (f)  Ernst & Young LLP, whose report on the financial statements of
     the Company is filed with the Commission as part of the Registration
     Statement and Prospectus, are independent public accountants as required by
     the Act.

          (g)  All legal or governmental proceedings, all statutes and
     regulations and all contracts, leases or documents of a character required
     to be described in the Registration Statement or the Prospectus or to be
     filed as an exhibit to the Registration Statement have been so described or
     filed as required. All statistical and market-related data included in the
     Prospectus are based on or derived from sources that the Company believes
     to be reliable and accurate, and the Company has obtained the written
     consent to the use of such data from such sources to the extent required.

          (h)  Except as set forth in the Registration Statement and the
     Prospectus: (i) no person has the right, contractual or otherwise, to cause
     the Company to issue to it, or register pursuant to the Act, any shares of
     capital stock or other equity interests; and (ii) no person has any
     preemptive rights, co-sale rights, rights of first refusal or other rights
     to purchase any shares of Common Stock. No person has the right,
     contractual or otherwise, to cause the Company to register under the Act
     any shares of capital stock or other equity interests as a result of the
     filing or effectiveness of the Registration Statement or the sale of the
     Shares as contemplated thereby.

          (i)  Immediately after the issuance and sale of the Shares to the
     Underwriters, no shares of preferred stock of the Company shall be issued
     and outstanding, and no holder of any shares of capital stock, securities
     convertible into or exchangeable or exercisable for capital stock or
     options, warrants or other rights to purchase capital stock or any other
     securities of the Company shall have any existing or future right to
     acquire any shares of preferred stock of the Company.

          (j)  The Company is not, and after the offering and sale of the
     Shares, will not be, an "investment company" or an entity "controlled" by
     an "investment company," as such terms are defined in the Investment
     Company Act of 1940, as amended (the "Investment Company Act").
                                           ----------------------

                                       5
<PAGE>

          (k)  The Company has obtained for the benefit of the Underwriters the
     agreement (a "Lock-Up Agreement") of each of its officers and directors
                   -----------------
     and each of its holders of Common Stock and securities convertible into or
     exchangeable or exercisable for Common Stock (including options and
     warrants) not to sell, offer to sell, contract to sell, hypothecate,
     pledge, grant any option to sell or otherwise dispose of, directly or
     indirectly, or file or participate in the filing of a registration
     statement under the Act relating to the offer and sale of, any shares of
     Common Stock or securities convertible into or exercisable or exchangeable
     for Common Stock or options, warrants or other rights to purchase Common
     Stock or any other securities of the Company that are substantially similar
     to Common Stock for a period of one hundred and eighty (180) days after the
     date of the Prospectus without the prior written consent of UBSW.

          (l)  Neither the Company nor any of its affiliates has taken, directly
     or indirectly, any action designed to or which has constituted or which
     might reasonably be expected to cause or result, under the Exchange Act or
     otherwise, in stabilization or manipulation of the price of any security of
     the Company to facilitate the sale or resale of the Shares.

          (m)  The Company has been duly organized and is validly existing as a
     corporation and is in good standing under the laws of the State of
     Delaware, and has full power and authority to own, lease and operate its
     properties and conduct its business as described in the Registration
     Statement.

          (n)  The Company is duly qualified to do business as a foreign
     corporation and is in good standing in each jurisdiction in which the
     ownership or leasing of its properties or the conduct of its business
     requires such qualification, except where the failure to so qualify would
     have a material adverse effect on the business, prospects, properties,
     condition (financial or otherwise) or results of operation of the Company
     and the Subsidiary (as defined herein), taken as a whole (a "Material
                                                                  --------
     Adverse Effect"). The Company does not have any subsidiaries (as defined in
     --------------
     the Act) other than Chrysalis DNX Transgenic Sciences Corporation (the
     "Subsidiary"). The Company owns 100% of the outstanding capital stock of
      ----------
     the Subsidiary. Other than the Subsidiary, the Company does not own,
     directly or indirectly, any shares of stock or any other equity or long-
     term debt securities of any corporation or have any equity interest in any
     firm, partnership, limited liability company, joint venture, association or
     other entity except as contemplated by the Prospectus and set forth in the
     Registration Statement and the Prospectus. Complete and correct copies of
     the charter and bylaws and other organizational documents of the Company
     and the Subsidiary and all amendments thereto have been delivered to you,
     and except as described in the Prospectus and set forth in the exhibits to
     the Registration Statement, no changes therein will be made subsequent to
     the date hereof and prior to the time of purchase or, if later, the
     additional time of purchase. The Subsidiary has been duly organized and is
     validly existing as a corporation and is in good standing under the laws of
     the jurisdiction of its incorporation, and has the full power and authority
     to own, lease and operate its properties and conduct its business, except
     where the failure to be so organized or existing would not have a Material
     Adverse Effect. The Subsidiary is duly qualified to do business as a
     foreign corporation and is in good standing in each jurisdiction in which
     the ownership or leasing of its properties or the conduct of its business
     requires such qualification, except where the

                                       6
<PAGE>

     failure to so qualify would not have a Material Adverse Effect. All of the
     outstanding shares of capital stock of the Subsidiary has been duly and
     validly authorized and issued and are fully paid and non-assessable and
     owned by the Company, free of any security interest, other encumbrance or
     adverse claims, have been issued in compliance with all federal and state
     securities laws and have not been issued in violation of any preemptive
     right, resale right, right of first refusal or similar right. No option,
     warrant or other rights to purchase, agreements or other obligations to
     issue or rights to convert any obligation into shares of capital stock or
     ownership interests in the Subsidiary are outstanding.

          (o)  The capital stock of the Company, including the Shares, conforms
     in all material respects to the description thereof contained in the
     Registration Statement and Prospectus. As of the date of this Agreement,
     the Company has an authorized and outstanding capital stock as set forth
     under the heading entitled "Actual" in the section of the Registration
     Statement and the Prospectus entitled "Capitalization" and, as of the time
     of purchase, and assuming the receipt and application of the net proceeds
     as described under the section of the Registration Statement and the
     Prospectus entitled "Use of proceeds," the Company shall have an authorized
     and outstanding capital stock as set forth under the heading entitled "Pro
     forma as adjusted" in the section of the Registration Statement and the
     Prospectus entitled "Capitalization." All of the outstanding shares of
     capital stock of the Company have been duly and validly authorized and
     issued and are fully paid and non-assessable, have been issued in
     compliance with all federal and state securities laws and have not have
     been issued in violation of any preemptive right, resale right, right of
     first refusal or similar right. The shares of Common Stock issuable upon
     conversion of the outstanding preferred stock of the Company upon
     completion of the offering contemplated hereby have been duly and validly
     authorized and reserved for issuance, and upon issuance, they will be duly
     and validly issued and fully paid and non-assessable, will have been issued
     in compliance with all federal and state securities laws and will not have
     been issued in violation of any preemptive right, resale right, right of
     first refusal or similar right.

          (p)  Neither the Company nor the Subsidiary has violated or is in
     violation of any federal, state, local or foreign law, ordinance,
     administrative or governmental rule or regulation applicable to the Company
     or the Subsidiary or of any decree of any court or governmental agency or
     body having jurisdiction over the Company or the Subsidiary, which
     violation could, individually or in the aggregate, have a Material Adverse
     Effect.

          (q)  Neither the Company nor the Subsidiary is in breach or violation
     of, or in default under (and no event has occurred which with notice, lapse
     of time, or both would result in any breach or violation of, or constitute
     a default under), its charter or bylaws or other organizational documents
     or in the performance or observance of any obligation, agreement, covenant
     or condition contained in any indenture, mortgage, deed of trust, bank loan
     or credit agreement or other evidence of indebtedness, or any lease,
     contract or other agreement or instrument to which the Company or the
     Subsidiary is a party or by which either of them or any of their properties
     is bound or affected, the effect of which could individually or in the
     aggregate have a Material Adverse Effect. The execution, delivery and
     performance of this Agreement and the issuance and sale of the Shares
     contemplated hereby and by the Registration Statement will not conflict
     with, or result in

                                       7
<PAGE>

     any breach or violation of, or constitute a default under), its charter or
     bylaws or other organizational documents or in the performance or
     observance of any obligation, agreement, covenant or condition contained in
     any indenture, mortgage, deed of trust, bank loan or credit agreement or
     other evidence of indebtedness, or any lease, contract or other agreement
     or instrument to which the Company or the Subsidiary is a party or by which
     either of them or any of their properties is bound or affected, the effect
     of which could individually or in the aggregate have a Material Adverse
     Effect. The execution, delivery and performance of this Agreement and the
     issuance and sale of the Shares contemplated hereby and by the Registration
     Statement will not conflict with, or result in any breach or violation of
     or constitute a default under (nor constitute any event which with notice,
     lapse of time, or both would result in any breach or violation of, or
     constitute a default under), any provisions of the charter or bylaws or
     other organizational documents of the Company or the Subsidiary or under
     any provision of any license, permit, franchise, indenture, mortgage, deed
     of trust, bank loan or credit agreement or other evidence of indebtedness,
     or any lease, contract or other agreement or instrument to which the
     Company or the Subsidiary is a party or by which either of them or their
     properties may be bound or affected, or under any federal, state, local or
     foreign law, regulation or rule or any decree, judgment or order applicable
     to the Company or the Subsidiary, the result of which could individually or
     in the aggregate have a Material Adverse Effect; and the execution,
     delivery and performance of this Agreement and the issuance and sale of the
     Shares contemplated hereby and by the Registration Statement will not
     conflict with, or result in any breach or violation of, constitute a
     default under (nor constitute any event which with notice, lapse of time,
     or both would result in any breach or violation of, or constitute a default
     under) or result in the creation or imposition of any lien, charge or
     encumbrance upon any property or assets of the Company or the Subsidiary
     pursuant to any indenture, mortgage, deed of trust, bank loan or credit
     agreement or other evidence of indebtedness, or any lease, contract or
     other agreement or instrument to which the Company or the Subsidiary is a
     party or by which either of them or any of their properties is bound or
     affected, the result of which could individually or in the aggregate have a
     Material Adverse Effect.

          (r)  Each of the Company and the Subsidiary has all necessary
     licenses, permits, franchises, authorizations, consents and approvals, and
     made all filings required under any federal, state, local or foreign law,
     regulation or rule, and has obtained all necessary authorizations, consents
     and approvals from other persons, in order to conduct its business; and
     neither the Company nor the Subsidiary is in violation of, or in default
     under, any such license, permit, franchise, authorization, consent or
     approval, the effect of which could individually or in the aggregate have a
     Material Adverse Effect.

          (s)  There are no private or governmental actions, suits, claims,
     investigations or proceedings pending, threatened or, to the Company's
     knowledge, contemplated, to which the Company or the Subsidiary or any of
     their directors or officers is subject or of which any of their properties
     is subject, whether at law, in equity or before or by any federal, state,
     local or foreign governmental or regulatory commission, board, body,
     authority or agency.

          (t)  Except as described in the Registration Statement and the
     Prospectus, subsequent to the respective dates as of which information is
     given in the Registration Statement and the Prospectus, there has not been
     (i) any material adverse change, or any development involving a prospective
     material adverse change, in the business, prospects, properties, condition
     (financial or otherwise) or results of operations of the Company and the
     Subsidiary, taken as a whole, (ii) any transaction that is material to the
     Company and the Subsidiary, taken as a whole, (iii) the incurrence by the
     Company or the Subsidiary of any obligation, direct or contingent, and
     whether or not in the ordinary course of business, which is material to the
     Company and the Subsidiary, taken as a whole, (iv) any change in the
     capital stock or other equity interest or outstanding indebtedness of the

                                       8
<PAGE>

     Company or the Subsidiary or (v) any dividend or distribution of any kind
     declared, paid or made on the capital stock or other equity interest of the
     Company. Neither the Company nor the Subsidiary has any contingent
     obligations that are material to the Company and the Subsidiary, taken as a
     whole, and are not disclosed in the Registration Statement.

          (u)  The Company owns or has obtained enforceable licenses for the
     patents, patent applications, inventions, technology, trademarks, trademark
     registrations, service marks, service mark registrations, trade names,
     copyrights, trade secrets and rights described in the Prospectus as being
     owned or used by or licensed to the Company or the Subsidiary or necessary
     for the conduct of their respective businesses as currently conducted
     (collectively, the "Intellectual Property"). Except as set forth in the
                         ---------------------
     Prospectus, there are no rights of third parties to any such Intellectual
     Property; and to the Company's knowledge, there is no infringement by third
     parties of any such Intellectual Property. There is no pending or, to the
     Company's knowledge, threatened action, suit, proceeding or claim by others
     (i) challenging the Company's rights in or to any such Intellectual
     Property; (ii) challenging the validity or scope of any such Intellectual
     Property; or (iii) that the Company or the Subsidiary infringes or
     otherwise violates, or would infringe or otherwise violate upon
     commercialization of its products and product candidates described in the
     Prospectus, any patent, trademark, copyright, trade secret or other
     proprietary rights of others; and the Company is unaware of any facts which
     would form a reasonable basis for of the claims described in clauses (i),
     (ii) and (iii) above. To the Company's knowledge there is no patent or
     patent application which contains claims that dominate or may dominate any
     Intellectual Property described in the Prospectus as being owned by or
     licensed to the Company or the Subsidiary or that is necessary for the
     conduct of their respective businesses as currently or contemplated to be
     conducted or that interferes with the issued or pending claims of any such
     Intellectual Property. There is no prior art of which the Company is aware
     that may render any patent held by the Company invalid or any patent
     application held by the Company unpatentable which has not been disclosed
     to the U.S. Patent and Trademark Office. The commercial products and
     product candidates of the Company and the Subsidiary described in the
     Prospectus read on the claims contained in the patents and patent
     applications described in the Prospectus.

          (v)  Each of the Company and the Subsidiary has good and marketable
     title to all property (real and personal) described in the Prospectus as
     being owned by them, free and clear of all liens, claims, security
     interests or other encumbrances except such as are described in the
     Registration Statement and the Prospectus and except as would not
     individually or in the aggregate have a Material Adverse Effect. All the
     property held under lease by the Company or the Subsidiary is held thereby
     under valid, subsisting and enforceable leases.

          (w)  Each of the Company and the Subsidiary is insured by insurers of
     recognized financial responsibility against such losses and risks and in
     such amount as are customary in the business in which it is engaged. All
     policies of insurance insuring the Company, the Subsidiary or any of their
     businesses, assets, employees, officers and directors are in full force and
     effect, and each of the Company and the Subsidiary is in compliance with

                                       9
<PAGE>

     the terms of such policies in all material respects. There are no claims by
     the Company or the Subsidiary under any such policy or instrument as to
     which any insurance company is denying liability or defending under a
     reservation of rights clause.

          (x)  The Company has neither sent nor received any notice of
     termination of any of the contracts or agreements referred to or described
     in, or filed as an exhibit to, the Registration Statement, and no such
     termination has been threatened by the Company or any other party to any
     such contract or agreement.

          (y)  Since the date of the latest audited financial statements
     included in the Prospectus, neither the Company nor the Subsidiary has
     sustained any loss or interference with its business from fire, explosion,
     flood or other calamity, whether or not covered by insurance, or from any
     labor dispute or court or governmental action, order or decree, otherwise
     than as disclosed in the Prospectus or other than any loss or interference
     which could individually or in the aggregate have a Material Adverse
     Effect.

          (z)  The Company and the Subsidiary maintain a system of internal
     accounting controls sufficient to provide reasonable assurances that (i)
     transactions are executed in accordance with management's general or
     specific authorization; (ii) transactions are recorded as necessary to
     permit preparation of financial statements in conformity with generally
     accepted accounting principles and to maintain accountability for assets;
     (iii) access to assets is permitted only in accordance with management's
     general or specific authorization; and (iv) the recorded accountability for
     assets is compared with existing assets at reasonable intervals and
     appropriate action is taken with respect to any differences.

          (aa) Each of the Company and the Subsidiary has filed all federal,
     state, local and foreign tax returns and tax forms required to be filed.
     Such returns and forms are complete and correct in all material respects,
     and all taxes shown by such returns or otherwise assessed that are due or
     payable have been paid, except such taxes as are being contested in good
     faith and as to which adequate reserves have been provided. All payroll
     withholdings required to be made by the Company and the Subsidiary with
     respect to employees have been made. The charges, accruals and reserves on
     the books of the Company and the Subsidiary in respect of any tax liability
     for any year not finally determined are adequate to meet any assessments or
     reassessments for additional taxes. There have been no tax deficiencies
     asserted and, to the Company's knowledge, no tax deficiency might be
     reasonably asserted or threatened against the Company or the Subsidiary
     that could individually or in the aggregate have a Material Adverse Effect.

          In addition, any certificate signed by any officer of the Company,
delivered to the Representatives or counsel for the Underwriters in connection
with the offering of the Shares shall be deemed to be a representation and
warranty by the Company, as to matters covered thereby, to each Underwriter.

          4.  Representations and Warranties of the Underwriters. You, on behalf
              --------------------------------------------------
of the several Underwriters, represent and warrant to the Company that the
information provided by you and set forth in the fifth, sixth, eighth, ninth,
tenth, eleventh, twelfth and fourteenth

                                       10
<PAGE>

paragraphs under the caption "Underwriting" in the Prospectus constitute the
only information provided by or on behalf of the Underwriters through you for
use in the Registration Statement and the Prospectus. You represent and warrant
that you have been authorized by each of the other Underwriters to enter into
this Agreement on behalf of each of the other Underwriters and to act for each
of them in the manner herein provided.

          5.  Certain Covenants.  The Company hereby agrees:
              -----------------

          (a)  to furnish such information as may be required and otherwise to
     cooperate in qualifying the Shares for offering and sale under the
     securities or blue sky laws of such states as you may designate and to
     maintain such qualifications in effect so long as required for the
     distribution of the Shares; provided, however, that the Company shall not
                                 --------  -------
     be required to qualify as a foreign corporation or to consent to the
     service of process under the laws of any such state (except service of
     process with respect to the offering and sale of the Shares); and to
     promptly advise you of the receipt of any notification with respect to the
     suspension of the qualification of the Shares for sale in any jurisdiction
     or the initiation or threatening of any proceeding for such purpose;

          (b)  to make available to the Underwriters in New York City, as soon
     as practicable after the Registration Statement becomes effective, and
     thereafter from time to time to furnish to the Underwriters, as many copies
     of the Prospectus (or of the Prospectus as amended or supplemented if the
     Company shall have made any amendments or supplements thereto after the
     effective date of the Registration Statement) as the Underwriters may
     request for the purposes contemplated by the Act; in case any Underwriter
     is required to deliver a prospectus beyond the nine-month period referred
     to in Section 10(a)(3) of the Act in connection with the sale of the
     Shares, the Company will prepare promptly upon request and at its cost such
     amendment or amendments to the Registration Statement and such prospectuses
     as may be necessary to permit compliance with the requirements of Section
     10(a)(3) of the Act;

          (c)  to advise you promptly and (if requested by you) to confirm such
     advice in writing, (i) when the Registration Statement has become effective
     and when any post-effective amendment thereto becomes effective and (ii) if
     Rule 430A under the Act is used, when the Prospectus is filed with the
     Commission pursuant to Rule 424(b) under the Act (which the Company agrees
     to file in a timely manner under such Rules);

          (d)  to advise you promptly, and to confirm such advice in writing, of
     any request by the Commission for amendments or supplements to the
     Registration Statement or Prospectus or for additional information with
     respect thereto, or of notice of institution of proceedings for, or the
     entry of a stop order suspending the effectiveness of the Registration
     Statement and, if the Commission should enter a stop order suspending the
     effectiveness of the Registration Statement, to use its best efforts to
     obtain the lifting or removal of such order as soon as possible; to advise
     you promptly of any proposal to amend or supplement the Registration
     Statement or Prospectus and to file no such amendment or supplement to
     which you shall object in writing;

                                       11
<PAGE>

          (e)  subject to Section 5(o) hereof, to file promptly all reports and
     any definitive proxy or information statement required to be filed by the
     Company with the Commission in order to comply with the Exchange Act
     subsequent to the date of the Prospectus and for so long as the delivery of
     a prospectus is required in connection with the offering or sale of the
     Shares, and to promptly notify you of such filing;

          (f)  if necessary or appropriate, to file in a timely fashion a
     registration statement pursuant to Rule 462(b) under the Act;

          (g)  to furnish to you and, upon request, to each of the other
     Underwriters for a period of five (5) years from the date of this Agreement
     (i) copies of any reports or other communications which the Company shall
     send to its stockholders or shall from time to time publish or publicly
     disseminate, (ii) copies of all annual, quarterly and current reports filed
     with the Commission on Forms 10-K, 10-Q and 8-K, or such other similar form
     as may be designated by the Commission, (iii) copies of documents or
     reports filed with any national securities exchange on which any class of
     securities of the Company is listed and (iv) such other information as you
     may reasonably request regarding the Company or the Subsidiary as soon as
     such communications, documents or information becomes available;

          (h)  to advise the Underwriters promptly of the occurrence of any
     event known to the Company within the time during which a Prospectus
     relating to the Shares is required to be delivered under the Act which
     would require the making of any change in the Prospectus then being used so
     that the Prospectus would not include an untrue statement of a material
     fact or omit to state a material fact necessary to make the statements
     therein, in the light of the circumstances under which they are made, not
     misleading, and, during such time, to prepare, file (subject to Section
     5(d) hereof) and furnish promptly to the underwriters, at the Company's
     expense, such amendments or supplements to such Prospectus as may be
     necessary to reflect any such change and to furnish you a copy of such
     proposed amendment or supplement before filing any such amendment or
     supplement with the Commission;

          (i)  to make generally available to its security holders, and to
     deliver to you, as soon as practicable an earnings statement of the Company
     (which will satisfy the provisions of Section 11(a) of the Act) covering a
     period of twelve (12) months beginning after the effective date of the
     Registration Statement (as defined in Rule 158(c) of the Act) and ending
     not later than fifteen (15) months thereafter;

          (j)  to furnish to its stockholders as soon as practicable after the
     end of each fiscal year an annual report (including a balance sheet and
     statements of income, stockholders' equity and of cash flow of the Company
     for such fiscal year, accompanied by a copy of the certificate or report
     thereon of nationally recognized independent certified public accountants);

          (k)  to furnish to you such number of conformed copies of the
     Registration Statement, as initially filed with the Commission, and of all
     amendments thereto (including all exhibits thereto) as you shall reasonably
     request;

                                       12
<PAGE>

          (l)  to furnish to you as early as practicable prior to the time of
     purchase and the additional time of purchase, as the case may be, but not
     later than two (2) business days prior thereto, a copy of the latest
     available quarterly or monthly unaudited interim consolidated financial
     statements of the Company and the Subsidiary, which have been read by the
     Company's independent certified public accountants, as stated in their
     letter to be furnished pursuant to Section 7(d) hereof;

          (m)  to apply the net proceeds from the sale of the Shares in the
     manner set forth under the caption "Use of proceeds" in the Prospectus;

          (n)  to pay all costs, expenses, fees and taxes in connection with (i)
     the preparation and filing of the Registration Statement, each Preliminary
     Prospectus, the Prospectus, and any amendments or supplements thereto, and
     the printing and furnishing of copies of each thereof to the Underwriters
     and to dealers (including costs of mailing and shipment), (ii) the
     registration, issue, sale and delivery of the Shares, (iii) the producing,
     word processing and/or printing of this Agreement, any agreement Among
     Underwriters, any dealer agreements, any Powers of Attorney and any closing
     documents (including compilations thereof) and the reproduction and/or
     printing and furnishing of copies of each thereof to the Underwriters and
     (except closing documents) to dealers (including costs of mailing and
     shipment), (iv) the qualification of the Shares for offering and sale under
     state laws and the determination of their eligibility for investment under
     state law as aforesaid (including the reasonable legal fees and filing fees
     and other disbursements of counsel for the Underwriters) and the printing
     and furnishing of copies of any blue sky surveys or legal investment
     surveys to the Underwriters and to dealers, (v) all out-of-pocket expenses
     (including the reasonable legal fees and filing fees and other
     disbursements of counsel for the Underwriters) incurred by the Underwriters
     in administering the Directed Share Program, (vi) any listing of the Shares
     on any securities exchange or qualification of the Shares for quotation on
     the National Association of Securities Dealers Automated Quotation National
     Market System ("NASDAQ") and any registration thereof under the Exchange
                     ------
     Act, (vii) the review of the public offering of the Shares by the NASD,
     including the associated filing fees and the reasonable fees and
     disbursements of counsel for the Underwriters and (viii) the performance of
     the Company's other obligations hereunder;

          (o)  to furnish to you, before filing with the Commission subsequent
     to the effective date of the Registration Statement and during the period
     referred to in paragraph (h) above, a copy of any document proposed to be
     filed pursuant to Section 13, 14 or 15(d) of the Exchange Act;

          (p)  not to sell, offer to sell, contract to sell, hypothecate,
     pledge, grant any option to sell or otherwise dispose of, directly or
     indirectly, any shares of Common Stock or securities convertible into or
     exchangeable or exercisable for Common Stock or options, warrants or other
     rights to purchase Common Stock or any other shares of the Company that are
     substantially similar to Common Stock or file a registration statement
     under the Act relating to the offer and sale of any shares of Common Stock
     or securities convertible into or exercisable or exchangeable for Common
     Stock or options, warrants or other rights to purchase Common Stock or any
     other shares of the Company that are

                                       13
<PAGE>

     substantially similar to Common Stock for a period of one hundred and
     eighty (180) days after the date hereof (the "Lock-up Period"), without the
                                                   --------------
     prior written consent of UBSW, except for (i) the registration of the
     Shares and the sales to the Underwriters pursuant to this Agreement, (ii)
     issuances of Common Stock upon the exercise of outstanding options or
     warrants as disclosed in the Registration Statement and the Prospectus to
     persons who have entered into Lock-Up Agreements with the Underwriters and
     (iii) the issuance of employee stock options not exercisable during the
     Lock-up Period pursuant to stock option plans described in the Registration
     Statement and the Prospectus; and

          (q)  to use its best efforts to cause the Common Stock to be listed
     for quotation on the Nasdaq National Market.

          6.  Reimbursement of Underwriters' Expenses. The Company agrees that
              ---------------------------------------
if the Shares are not delivered for any reason, other than the termination of
this Agreement pursuant to subsections (ii), (iii) or (iv) of the second
paragraph of Section 8 hereof or the last paragraph of Section 9 hereof or the
default by one or more of the Underwriters in its or their respective
obligations hereunder, it shall, in addition to paying the amounts described in
Section 5(n) hereof, reimburse the Underwriters for all of the out-of-pocket
accountable expenses actually incurred by the Underwriters, including the
reasonable fees and disbursements of their counsel.

          7.  Conditions of Underwriters' Obligations. The several obligations
              ---------------------------------------
of the Underwriters hereunder are subject to the accuracy of the representations
and warranties of the Company on the date hereof and at the time of purchase as
if made at the time of purchase (and the several obligations of the Underwriters
at the additional time of purchase are subject to the accuracy of the
representations and warranties of the Company on the date hereof and at the time
of purchase (unless previously waived) and at the additional time of purchase,
as the case may be, as if made at such time), the timely performance by the
Company of its obligations hereunder and to the following additional conditions
precedent:

          (a)  The Company shall furnish to you at the time of purchase and at
     the additional time of purchase, as the case may be, an opinion of Wilson
     Sonsini Goodrich & Rosati, P.C., counsel for the Company, addressed to the
     Underwriters, and dated the time of purchase or the additional time of
     purchase, as the case may be, with reproduced copies for each of the other
     Underwriters and in form reasonably satisfactory to Dewey Ballantine LLP,
     counsel for the Underwriters, stating that:

               (i)   the Company has been duly incorporated and is validly
          existing as a corporation and is in good standing under the laws of
          the State of Delaware and has full power and authority to own, lease
          and operate its properties and conduct its business as described in
          the Registration Statement and the Prospectus, to execute and deliver
          this Agreement and to issue, sell and deliver the Shares as herein
          contemplated;

               (ii)  the Subsidiary has been duly incorporated and is validly
          existing as a corporation and is in good standing under the laws of
          its jurisdiction of incorporation and has full power and authority to
          own, lease and operate its

                                       14
<PAGE>

          properties and conduct its business as described in the Registration
          Statement and the Prospectus;

               (iii)   each of the Company and the Subsidiary is duly qualified
          to do business as a foreign corporation and is in good standing in
          each jurisdiction in which the ownership or leasing of its properties
          or the conduct of its business requires such qualification, except
          where the failure to so qualify would not have a Material Adverse
          Effect;

               (iv)    this Agreement has been duly authorized, executed and
          delivered by the Company;

               (v)     the Shares have been duly authorized and, when issued and
          delivered to and paid for by the Underwriters, will be validly issued,
          fully paid and non-assessable;

               (vi)    the Company has authorized and outstanding shares of
          capital stock as set forth in the Registration Statement and the
          Prospectus; the outstanding shares of capital stock of the Company (A)
          have been duly and validly authorized and issued and are fully paid
          and non-assessable, (B) are free of any preemptive rights, resale
          rights, rights of first refusal and similar rights under the Delaware
          General Corporation Law or under any contract, agreement or instrument
          described in or filed as an exhibit to the Registration Statement or
          otherwise known to such counsel and (C) to such counsel's knowledge,
          were issued in compliance with all applicable federal and state
          securities laws; the Shares when issued will be free of any preemptive
          rights, resale rights, rights of first refusal and similar rights
          under the Delaware General Corporation Law or the charter or bylaws or
          other organizational documents of the Company or under any contract,
          agreement or instrument known to such counsel, and the holders of the
          Shares will not be subject to personal liability by reason of being
          such holders; the certificates for the Shares are in due and proper
          form and conform in all material respects to the requirements of the
          Delaware General Corporation Law;

               (vii)   all of the outstanding shares of capital stock of the
          Subsidiary have been duly authorized and validly issued, are fully
          paid and non-assessable, are owned of record by the Company, are not
          subject to any perfected security interest or, to such counsel's
          knowledge, any other encumbrance or adverse claim and, to such
          counsel's knowledge, have been issued and sold in compliance with all
          applicable federal and state securities laws; to such counsel's
          knowledge, no options, warrants or other rights to purchase,
          agreements or other obligations to issue or other rights to convert
          any obligation into shares of capital stock or ownership interests in
          the Subsidiary are outstanding.

               (viii)  the capital stock of the Company, including the Shares,
          conforms as to legal matters to the description thereof contained in
          the Registration Statement and Prospectus;

                                       15
<PAGE>

               (ix)    the Registration Statement and the Prospectus (except as
          to the financial statements and schedules and other financial and
          statistical data contained therein, as to which such counsel need
          express no opinion) comply as to form in all material respects with
          the requirements of the Act;

               (x)     the Registration Statement has become effective under the
          Act and, to such counsel's knowledge, no stop order proceedings with
          respect thereto are pending or threatened under the Act and any
          required filing of the Prospectus, and any supplement thereto pursuant
          to Rule 424 under the Act, has been made in the manner and within the
          time period required by such Rule 424;

               (xi)    no approval, authorization, consent or order of or filing
          with any national, state or local governmental or regulatory
          commission, board, body, authority or agency is required in connection
          with the execution, delivery and performance of this Agreement, the
          issuance and sale of the Shares and the consummation of the
          transactions contemplated hereby and by the Registration Statement,
          other than those that have been obtained under the Act, the Exchange
          Act and the rules of the Nasdaq National Market and other than any
          necessary qualification under the state securities or blue sky laws of
          the various jurisdictions in which the Shares are being offered by the
          Underwriters or any necessary approval of the Corporate Financing
          Department of NASD Regulation, Inc., as to which such qualification
          and approval such counsel need express no opinion;

               (xii)   the execution, delivery and performance of this Agreement
          by the Company and the transactions contemplated hereby and by the
          Registration Statement do not and will not conflict with, or result in
          any breach or violation of, or constitute a default under (nor
          constitute any event which with notice, lapse of time, or both, would
          result in any breach or violation of, or constitute a default under)
          or result in the creation or imposition of any lien, charge or
          encumbrance upon any property or assets of the Company or the
          Subsidiary pursuant to (A) any provisions of the charter or bylaws or
          other organizational documents of the Company or the Subsidiary, (B)
          any provision of any license, permit, franchise, indenture, mortgage,
          deed of trust, bank loan or credit agreement or other evidence of
          indebtedness, or any lease, contract or other agreement or instrument
          to which the Company or the Subsidiary is a party or by which their
          respective properties may be bound or affected that is known by such
          counsel, (C) any federal, state, local or foreign law, regulation or
          rule or (D) any decree, judgment or order applicable to the Company or
          the Subsidiary, or any license, permit or franchise issued to the
          Company or the Subsidiary, in each case known to such counsel, or (E)
          any contract, indenture, mortgage, deed of trust, loan or credit
          agreement, note, lease or any other agreement or instrument, filed as
          an exhibit to the Registration Statement or otherwise known to such
          counsel, to which the Company or the Subsidiary is a party or by which
          either of them may be bound, or to which any of the property or assets
          of the Company or the Subsidiary is subject;

                                       16
<PAGE>

               (xiii)  to such counsel's knowledge, neither the Company nor the
          Subsidiary is in violation of its charter or bylaws or other
          organizational documents, nor is either of them in breach or violation
          of or in default under (nor has any event occurred which with notice,
          lapse of time, or both would result in any breach or violation of, or
          constitute a default under), any license, permit, franchise,
          indenture, mortgage, deed of trust, bank loan or credit agreement or
          other evidence of indebtedness, or any lease, contract or other
          agreement or instrument to which the Company or the Subsidiary is or
          was a party or by which either of them or their respective properties
          may be bound or affected or in violation of any federal, state, local
          or foreign law, regulation or rule or any decree, judgment or order
          applicable to the Company or the Subsidiary, the effect of which would
          individually or in the aggregate have a Material Adverse Effect;

               (xiv)   to such counsel's knowledge, there are no contracts,
          licenses, agreements, leases or documents of a character which are
          required to be filed as exhibits to the Registration Statement or to
          be described in the Prospectus which have not been so filed or
          described;

               (xv)    to such counsel's knowledge, there are no private or
          governmental actions, suits, claims, investigations or proceedings
          pending, threatened or contemplated to which the Company or the
          Subsidiary or any of their directors or officers is subject or of
          which any of their properties is subject, whether at law, in equity or
          before or by any federal, state, local or foreign governmental or
          regulatory commission, board, body, authority or agency which are
          required to be described in the Prospectus but are not so described;

               (xvi)   the Company is not, and after the offering and sale of
          the Shares, will not be, an "investment company" or an entity
          controlled by an "investment company," as such terms are defined in
          the Investment Company Act;

               (xvii)  those statements in the Prospectus that are descriptions
          of contracts, agreements or other legal documents or of legal
          proceedings, or refer to statements of law or legal conclusions, are
          accurate in all material respects and present fairly the information
          required to be shown; and

               (xviii) no person has the right, pursuant to the terms of any
          contract, agreement or other instrument described in or filed as an
          exhibit to the Registration Statement or otherwise known to such
          counsel, to cause the Company to register under the Act any shares of
          capital stock or other equity interests as a result of the filing or
          effectiveness of the Registration Statement or the sale of the Shares
          as contemplated hereby; and to such counsel's knowledge, except as
          described in the Registration Statement and Prospectus, no person is
          entitled to registration rights with respect to shares of capital
          stock or other securities of the Company.

          In addition, such counsel shall state that it has participated in
conferences with officers and other representatives of the Company,
representatives of the independent public

                                       17
<PAGE>

accountants of the Company and representatives of the Underwriters at which the
contents of the Registration Statement and Prospectus were discussed and,
although such counsel is not passing upon and does not assume responsibility for
the accuracy, completeness or fairness of the statements contained in the
Registration Statement or Prospectus (except as and to the extent stated in
subparagraphs (vi), (viii) and (xvii) above), on the basis of the foregoing
nothing has come to the attention of such counsel that causes such counsel to
believe that the Registration Statement or any amendment thereto at the time
such Registration Statement or amendment became effective contained an untrue
statement of a material fact or omitted to state a material fact required to be
stated therein or necessary to make the statements therein not misleading, or
that the Prospectus or any supplement thereto at the date of such Prospectus or
such supplement, and at all times up to and including the time of purchase or
additional time of purchase, as the case may be, contained an untrue statement
of a material fact or omitted to state a material fact required to be stated
therein or necessary to make the statements therein, in light of the
circumstances under which they were made, not misleading (it being understood
that such counsel need express no opinion with respect to the financial
statements and schedules and other financial and statistical data included in
the Registration Statement or Prospectus).

          (b)  You shall have received at the time of purchase and at the
     additional time of purchase, as the case may be, the opinion of Wilson
     Sonsini Goodrich & Rosati, P.C., intellectual property counsel to the
     Company with respect to patents and proprietary rights, dated the time of
     purchase or the additional time of purchase, as the case may be, with
     reproduced copies for each of the other Underwriters and in form reasonably
     satisfactory to Dewey Ballantine LLP, counsel for the Underwriters, stating
     that:

               (i)     To such counsel's knowledge, except as described in the
          Prospectus, (A) the Company (either directly or through the
          Subsidiary) has valid license rights or clear title to the
          Intellectual Property referenced in the Prospectus, and there are no
          rights of third parties to any such Intellectual Property; (B) there
          is no infringement or other violation by third parties of any of the
          Intellectual Property of the Company referenced in the Prospectus; (C)
          there is no infringement or other violation by the Company or the
          Subsidiary of any Intellectual Property of others; (D) there is no
          pending or threatened action, suit proceeding or claim by governmental
          authorities or others that the Company or the Subsidiary infringes or
          otherwise violates any Intellectual Property of others, and such
          counsel is unaware of any facts which would form a reasonable basis
          for any such claim; and (E) there is no pending or threatened action,
          suit, proceeding or claim by governmental authorities or others
          challenging the rights of the Company or the Subsidiary in or to, or
          challenging the scope of, any Intellectual Property of the Company or
          the Subsidiary referenced in the Prospectus, and such counsel is
          unaware of any facts which would form a reasonable basis for any such
          claim;

               (ii)    to such counsel's knowledge, the patent applications of
          the Company and the Subsidiary presently on file disclose patentable
          subject matter, and such counsel is not aware of any inventorship
          challenges, any interference which has been declared or provoked, or
          any other material fact with respect to the patent applications of the
          Company presently on file that (A) would preclude

                                       18
<PAGE>

          the issuance of patents with respect to such applications, or (B)
          would lead such counsel to conclude that such patents, when issued,
          would not be valid and enforceable in accordance with applicable
          regulations; and

               (iii)   the statements in the Registration Statement and the
          Prospectus referencing Intellectual Property matters, insofar as such
          statements constitute summaries of legal matters, contracts,
          agreements, documents or proceedings referred to therein, or refer to
          statements of law or legal conclusions, are in all material respects
          accurate and complete statements or summaries of the matters therein
          set forth. Nothing has come to such counsel's attention that causes
          such counsel to believe that such above described portions of the
          Registration Statement, at the time such Registration Statement became
          effective, contained an untrue statement of a material fact or omitted
          to state a material fact required to be stated therein or necessary to
          make the statements therein not misleading, or that such above
          described portions of the Prospectus and at the date of the Prospectus
          and at all times leading up to and including the time of purchase and
          the additional time of purchase, as the case may be, contained an
          untrue statement of material fact or omitted to state a material fact
          required to be stated therein or necessary to make the statements
          therein, in light of the circumstances under which they were made, not
          misleading.

          (c)  You shall have received at the time of purchase and at the
     additional time of purchase, as the case may be, the favorable opinion of
     Dewey Ballantine LLP, counsel for the Underwriters, dated the time of
     purchase or the additional time of purchase, as the case may be, with
     respect to the issuance and sale of the Shares by the Company, the
     Registration Statement, the Prospectus (together with any supplement
     thereto) and such other related matters as the Underwriters may require.

          (d)  You shall have received from Ernst & Young LLP, letters dated,
     respectively, the date of this Agreement and the time of purchase and
     additional time of purchase, as the case may be, and addressed to the
     Underwriters (with reproduced copies for each of the Underwriters) in the
     forms heretofore approved by Dewey Ballantine LLP, counsel for the
     Underwriters.

          (e)  No amendment or supplement to the Registration Statement or
     Prospectus shall be filed prior to the time the Registration Statement
     becomes effective to which you object in writing.

          (f)  The Registration Statement shall become effective, or if Rule
     430A under the Act is used, the Prospectus shall have been filed with the
     Commission pursuant to Rule 424(b) under the Act, at or before 5:30 P.M.,
     New York City time, on the date of this Agreement, unless a later time (but
     not later than 5:30 P.M., New York City time, on the second full business
     day after the date of this Agreement) shall be agreed to by the Company and
     you in writing or by telephone, confirmed in writing; provided, however,
                                                           --------  -------
     that the Company and you and any group of Underwriters, including you, who
     have agreed hereunder to purchase in the aggregate at least fifty percent
     (50%) of the Firm Shares may from time to time agree on a later date.

                                       19
<PAGE>

          (g)  Prior to the time of purchase or the additional time of purchase,
     as the case may be, (i) no stop order with respect to the effectiveness of
     the Registration Statement shall have been issued under the Act or
     proceedings initiated under Section 8(d) or 8(e) of the Act; (ii) the
     Registration Statement and all amendments thereto, or modifications
     thereof, if any, shall not contain an untrue statement of a material fact
     or omit to state a material fact required to be stated therein or necessary
     to make the statements therein not misleading; and (iii) the Prospectus and
     all amendments or supplements thereto, or modifications thereof, if any,
     shall not contain an untrue statement of a material fact or omit to state a
     material fact required to be stated therein or necessary to make the
     statements therein, in the light of the circumstances under which they are
     made, not misleading.

          (h)  Between the time of execution of this Agreement and the time of
     purchase or the additional time of purchase, as the case may be, (i) no
     material and adverse change, or any development involving a prospective
     material and adverse change (other than as specifically identified in the
     Registration Statement and Prospectus), in the business, prospects,
     properties, condition (financial or otherwise) or results of operations of
     the Company and the Subsidiary, taken as a whole, shall occur or become
     known and (ii) no transaction which is material and unfavorable to the
     Company shall have been entered into by the Company or the Subsidiary.

          (i)  The Company will, at the time of purchase or additional time of
     purchase, as the case may be, deliver to you a certificate of its President
     and its Chief Financial Officer to the effect that the representations and
     warranties of the Company as set forth in this Agreement are true and
     correct as of each such date, that the Company has performed such of its
     obligations under this Agreement as are to be performed at or before the
     time of purchase and at or before the additional time of purchase, as the
     case may be, and the conditions set forth in paragraphs (f), (g) and (h) of
     this Section 7 have been met.

          (j)  You shall have received signed Lock-Up Agreements, dated the date
     of this Agreement, from each of the officers and directors of the Company
     and each of the holders of Common Stock and securities convertible into or
     exchangeable or exercisable for Common Stock (including options and
     warrants), stating that such persons will not sell, offer to sell, contract
     to sell, hypothecate, pledge, grant any option to sell or otherwise dispose
     of, directly or indirectly, or file or participate in the filing of a
     registration statement under the Act relating to the offer and sale of, any
     shares of Common Stock or securities convertible into or exchangeable or
     exercisable for Common Stock or options, warrants or other rights to
     purchase Common Stock or any other securities of the Company that are
     substantially similar to Common Stock for a period of one hundred and
     eighty (180) days after the date of the Prospectus without the prior
     written consent of UBSW.

          (k)  The Company shall have furnished to you such other documents and
     certificates as to the accuracy and completeness of any statement in the
     Registration Statement and the Prospectus as of the time of purchase and
     the additional time of purchase, as the case may be, as you may reasonably
     request.

                                       20
<PAGE>

          (l)  The Shares shall have been approved for listing for quotation on
     the Nasdaq National Market, subject only to notice of issuance at or prior
     to the time of purchase or the additional time of purchase, as the case may
     be.

          8.   Effective Date of Agreement; Termination. This Agreement shall
               ----------------------------------------
become effective (i) if Rule 430A under the Act is not used, when you shall have
received notification of the effectiveness of the Registration Statement, or
(ii) if Rule 430A under the Act is used, when the parties hereto have executed
and delivered this Agreement.

          The obligations of the several Underwriters hereunder shall be subject
to termination in the absolute discretion of you or any group of Underwriters
(which may include you) which has agreed to purchase in the aggregate at least
fifty percent (50%) of the Firm Shares, (i) if, since the time of execution of
this Agreement or the respective dates as of which information is given in the
Registration Statement and Prospectus, there has been any material adverse and
unfavorable change, or any development involving a prospective material adverse
change (other than as specifically identified in the Registration Statement and
Prospectus) in the business, prospects, properties, condition (financial or
otherwise) or results of operations of the Company and the Subsidiary taken as a
whole, which would, in your judgment or in the judgment of such group of
Underwriters, make it impracticable to market the Shares, or, (ii) if, at any
time prior to the time of purchase or, with respect to the purchase of any
Additional Shares, the additional time of purchase, as the case may be, trading
in securities on the New York Stock Exchange, the American Stock Exchange or the
Nasdaq National Market shall have been suspended or limitations or minimum
prices shall have been established on the New York Stock Exchange, the American
Stock Exchange or the Nasdaq National Market, or (iii) if a banking moratorium
shall have been declared either by the United States or New York State
authorities, or (iv) if the United States shall have declared war in accordance
with its constitutional processes or there shall have occurred any material
outbreak or escalation of hostilities or other national or international
calamity or crisis of such magnitude in its effect on the financial markets of
the United States as, in your judgment or in the judgment of such group of
Underwriters, to make it impracticable to market the Shares.

          If you or any group of Underwriters elects to terminate this Agreement
as provided in this Section 8, the Company and each other Underwriter shall be
notified promptly by letter or telegram.

          If the sale to the Underwriters of the Shares, as contemplated by this
Agreement, is not carried out by the Underwriters for any reason permitted under
this Agreement or if such sale is not carried out because the Company shall be
unable to comply with any of the terms of this Agreement, the Company shall not
be under any obligation or liability under this Agreement (except to the extent
provided in Sections 5(n), 6 and 10 hereof), and the Underwriters shall be under
no obligation or liability to the Company under this Agreement (except to the
extent provided in Section 10 hereof) or to one another hereunder.

          9.   Increase in Underwriters' Commitments. Subject to Sections 7 and
               -------------------------------------
8, if any Underwriter shall default in its obligation to take up and pay for the
Firm Shares to be purchased by it hereunder (otherwise than for a reason
sufficient to justify the termination of this Agreement under the provisions of
Section 8 hereof) and if the number of Firm Shares which all

                                       21
<PAGE>

Underwriters so defaulting shall have agreed but failed to take up and pay for
does not exceed ten percent (10%) of the total number of Firm Shares, the non-
defaulting Underwriters shall take up and pay for (in addition to the aggregate
number of Firm Shares they are obligated to purchase pursuant to Section 1
hereof) the number of Firm Shares agreed to be purchased by all such defaulting
Underwriters, as hereinafter provided. Such Shares shall be taken up and paid
for by such non-defaulting Underwriter or Underwriters in such amount or amounts
as you may designate with the consent of each Underwriter so designated or, in
the event no such designation is made, such Shares shall be taken up and paid
for by all non-defaulting Underwriters pro rata in proportion to the aggregate
number of Firm Shares set opposite the names of such non-defaulting Underwriters
in Schedule A.
   ----------

          Without relieving any defaulting Underwriter from its obligations
hereunder, the Company agrees with the non-defaulting Underwriters that it will
not sell any Firm Shares hereunder unless all of the Firm Shares are purchased
by the Underwriters (or by substituted Underwriters selected by you with the
approval of the Company or selected by the Company with your approval).

          If a new Underwriter or Underwriters are substituted by the
Underwriters or by the Company for a defaulting Underwriter or Underwriters in
accordance with the foregoing provision, the Company or you shall have the right
to postpone the time of purchase for a period not exceeding five (5) business
days in order that any necessary changes in the Registration Statement and
Prospectus and other documents may be effected.

          The term Underwriter as used in this Agreement shall refer to and
include any Underwriter substituted under this Section 9 with like effect as if
such substituted Underwriter had originally been named in Schedule A.
                                                          ----------

          If the aggregate number of Shares which the defaulting Underwriter or
Underwriters agreed to purchase exceeds ten percent (10%) of the total number of
Shares which all Underwriters agreed to purchase hereunder, and if neither the
non-defaulting Underwriters nor the Company shall make arrangements within the
five (5) business day period stated above for the purchase of all the Shares
which the defaulting Underwriter or Underwriters agreed to purchase hereunder,
this Agreement shall be terminated without further act or deed and without any
liability on the part of the Company to any non-defaulting Underwriter and
without any liability on the part of any non-defaulting Underwriter to the
Company. Nothing in this paragraph, and no action taken hereunder, shall relieve
any defaulting Underwriter from liability in respect of any default of such
Underwriter under this Agreement.

          10.  Indemnity and Contribution.
               --------------------------

          (a)  The Company agrees to indemnify, defend and hold harmless each
     Underwriter, its partners, directors and officers, and any person who
     controls any Underwriter within the meaning of Section 15 of the Act or
     Section 20 of the Exchange Act, and the successors and assigns of all of
     the foregoing persons from and against any loss, damage, expense, liability
     or claim (including the reasonable cost of investigation) which, jointly or
     severally, any such Underwriter or any such person may incur under the Act,
     the Exchange Act, the common law or otherwise, insofar as such loss,
     damage,

                                       22
<PAGE>

     expense, liability or claim arises out of or is based upon (i) any untrue
     statement or alleged untrue statement of a material fact contained in the
     Registration Statement (or in the Registration Statement as amended by any
     post-effective amendment thereof by the Company) or in a Prospectus (the
     term Prospectus for the purpose of this Section 10 being deemed to include
     any Preliminary Prospectus, the Prospectus and the Prospectus as amended or
     supplemented by the Company), or arises out of or is based upon any
     omission or alleged omission to state a material fact required to be stated
     in either such Registration Statement or Prospectus or necessary to make
     the statements made therein not misleading, except insofar as any such
     loss, damage, expense, liability or claim arises out of or is based upon
     any untrue statement or alleged untrue statement of a material fact
     contained in and in conformity with information furnished in writing by or
     on behalf of any Underwriter through you to the Company expressly for use
     with reference to such Underwriter in such Registration Statement or such
     Prospectus or arises out of or is based upon any omission or alleged
     omission to state a material fact in connection with such information
     required to be stated in such Registration Statement or such Prospectus or
     necessary to make such information not misleading or (ii) any untrue
     statement or alleged untrue statement made by the Company in Section 3 of
     this Agreement or the failure by the Company to perform when and as
     required any agreement or covenant contained herein or (iii) any untrue
     statement or alleged untrue statement of any material fact contained in any
     audio or visual materials provided by the Company or based upon written
     information furnished by or on behalf of the Company including, without
     limitation, slides, videos, films, tape recordings, used in connection with
     the marketing of the Shares or (iv) the Directed Share Program, provided
     that, the Company shall not be responsible for any loss, damage, expense,
     liability, or claim that is finally judicially determined to have resulted
     from the bad faith or gross negligence of the Underwriters in conducting
     the Directed Share Program.

          If any action, suit or proceeding (together, a "Proceeding") is
                                                          ----------
brought against an Underwriter or any such person in respect of which indemnity
may be sought against the Company pursuant to the foregoing paragraph, such
Underwriter or such person shall promptly notify the Company in writing of the
institution of such Proceeding and the Company shall assume the defense of such
Proceeding, including the employment of counsel reasonably satisfactory to such
indemnified party and payment of all fees and expenses; provided, however, that
                                                        --------  -------
the omission to so notify the Company shall not relieve the Company from any
liability which the Company may have to any Underwriter or any such person or
otherwise. Such Underwriter or such person shall have the right to employ its or
their own counsel in any such case, but the fees and expenses of such counsel
shall be at the expense of such Underwriter or of such person unless the
employment of such counsel shall have been authorized in writing by the Company
in connection with the defense of such Proceeding or the Company shall not have,
within a reasonable period of time in light of the circumstances, employed
counsel to defend such Proceeding or such indemnified party or parties shall
have reasonably concluded that there may be defenses available to it or them
which are different from, additional to or in conflict with those available to
the Company (in which case the Company shall not have the right to direct the
defense of such Proceeding on behalf of the indemnified party or parties), in
any of which events such fees and expenses shall be borne by the Company and
paid as incurred (it being understood, however, that the Company shall not be
liable for the expenses of more than one separate counsel (in addition to any
local counsel) in any one Proceeding or series of related Proceedings

                                       23
<PAGE>

in the same jurisdiction representing the indemnified parties who are parties to
such Proceeding). The Company shall not be liable for any settlement of any
Proceeding effected without the written consent of the Company but if settled
with the written consent of the Company, the Company agrees to indemnify and
hold harmless any Underwriter and any such person from and against any loss or
liability by reason of such settlement. Notwithstanding the foregoing sentence,
if at any time an indemnified party shall have requested an indemnifying party
to reimburse the indemnified party for fees and expenses of counsel as
contemplated by the second sentence of this paragraph, then the indemnifying
party agrees that it shall be liable for any settlement of any Proceeding
effected without its written consent if (i) such settlement is entered into more
than sixty (60) days after receipt by such indemnifying party of the aforesaid
request, (ii) such indemnifying party shall not have reimbursed the indemnified
party in accordance with such request prior to the date of such settlement and
(iii) such indemnified party shall have given the indemnifying party at least
thirty (30) days' prior notice of its intention to settle. No indemnifying party
shall, without the prior written consent of the indemnified party, effect any
settlement of any pending or threatened Proceeding in respect of which any
indemnified party is or could have been a party and indemnity could have been
sought hereunder by such indemnified party, unless such settlement includes an
unconditional release of such indemnified party from all liability on claims
that are the subject matter of such Proceeding and does not include an admission
of fault, culpability or a failure to act, by or on behalf of such indemnified
party.

          (b)  In connection with the offer and sale of the Reserved Shares, the
     Company agrees to pay UBSW, at its request, the full purchase price of all
     Reserved Shares which were subject to a properly confirmed agreement to
     purchase and for which any Directed Share Participant failed to pay
     therefor and accept delivery thereof.

          (c)  Each Underwriter severally agrees to indemnify, defend and hold
     harmless the Company, its directors and officers, and any person who
     controls the Company within the meaning of Section 15 of the Act or Section
     20 of the Exchange Act, and the successors and assigns of all of the
     foregoing persons from and against any loss, damage, expense, liability or
     claim (including the reasonable cost of investigation) which, jointly or
     severally, the Company or any such person may incur under the Act, the
     Exchange Act, the common law or otherwise, insofar as such loss, damage,
     expense, liability or claim arises out of or is based upon any untrue
     statement or alleged untrue statement of a material fact contained in and
     in conformity with information furnished in writing by or on behalf of such
     Underwriter through you to the Company expressly for use with reference to
     such Underwriter in the Registration Statement (or in the Registration
     Statement as amended by any post-effective amendment thereof by the
     Company) or in a Prospectus.

          If any Proceeding is brought against the Company or any such person in
respect of which indemnity may be sought against any Underwriter pursuant to the
foregoing paragraph, the Company or such person shall promptly notify such
Underwriter in writing of the institution of such Proceeding and such
Underwriter shall assume the defense of such Proceeding, including the
employment of counsel reasonably satisfactory to such indemnified party and
payment of all fees and expenses; provided, however, that the omission to so
                                  --------  -------
notify such Underwriter shall not relieve such Underwriter from any liability
which such Underwriter may have to the Company or any such person or otherwise.
The Company or such person shall have the right to employ its

                                       24
<PAGE>

own counsel in any such case, but the fees and expenses of such counsel shall be
at the expense of the Company or such person unless the employment of such
counsel shall have been authorized in writing by such Underwriter in connection
with the defense of such Proceeding or such Underwriter shall not have, within a
reasonable period of time in light of the circumstances, employed counsel to
have charge of the defense of such Proceeding or such indemnified party or
parties shall have reasonably concluded that there may be defenses available to
it or them which are different from or additional to or in conflict with those
available to such Underwriter (in which case such Underwriter shall not have the
right to direct the defense of such Proceeding on behalf of the indemnified
party or parties, but such Underwriter may employ counsel and participate in the
defense thereof but the fees and expenses of such counsel shall be at the
expense of such Underwriter), in any of which events such fees and expenses
shall be borne by such Underwriter and paid as incurred (it being understood,
however, that such Underwriter shall not be liable for the expenses of more than
one separate counsel (in addition to any local counsel) in any one Proceeding or
series of related Proceedings in the same jurisdiction representing the
indemnified parties who are parties to such Proceeding). No Underwriter shall be
liable for any settlement of any such Proceeding effected without the written
consent of such Underwriter but if settled with the written consent of such
Underwriter, such Underwriter agrees to indemnify and hold harmless the Company
and any such person from and against any loss or liability by reason of such
settlement. Notwithstanding the foregoing sentence, if at any time an
indemnified party shall have requested an indemnifying party to reimburse the
indemnified party for fees and expenses of counsel as contemplated by the second
sentence of this paragraph, then the indemnifying party agrees that it shall be
liable for any settlement of any Proceeding effected without its written consent
if (i) such settlement is entered into more than sixty (60) days after receipt
by such indemnifying party of the aforesaid request, (ii) such indemnifying
party shall not have reimbursed the indemnified party in accordance with such
request prior to the date of such settlement and (iii) such indemnified party
shall have given the indemnifying party at least thirty (30) days' prior notice
of its intention to settle. No indemnifying party shall, without the prior
written consent of the indemnified party, effect any settlement of any pending
or threatened Proceeding in respect of which any indemnified party is or could
have been a party and indemnity could have been sought hereunder by such
indemnified party, unless such settlement includes an unconditional release of
such indemnified party from all liability on claims that are the subject matter
of such Proceeding.

          (d)  If the indemnification provided for in this Section 10 is
     unavailable to an indemnified party under subsections (a), (b) or (c) of
     this Section 10 in respect of any losses, damages, expenses, liabilities or
     claims referred to therein, then each applicable indemnifying party, in
     lieu of indemnifying such indemnified party, shall contribute to the amount
     paid or payable by such indemnified party as a result of such losses,
     damages, expenses, liabilities or claims (i) in such proportion as is
     appropriate to reflect the relative benefits received by the Company on the
     one hand and the Underwriters on the other hand from the offering of the
     Shares or (ii) if the allocation provided by clause (i) above is not
     permitted by applicable law, in such proportion as is appropriate to
     reflect not only the relative benefits referred to in clause (i) above but
     also the relative fault of the Company on the one hand and of the
     Underwriters on the other in connection with the statements or omissions
     which resulted in such losses, damages, expenses, liabilities or claims, as
     well as any other relevant equitable considerations. The relative benefits
     received by the Company on the one hand and the Underwriters on the other
     shall be

                                       25
<PAGE>

     deemed to be in the same respective proportions as the total proceeds from
     the offering (net of underwriting discounts and commissions but before
     deducting expenses) received by the Company and the total underwriting
     discounts and commissions received by the Underwriters, bear to the
     aggregate public offering price of the Shares. The relative fault of the
     Company on the one hand and of the Underwriters on the other shall be
     determined by reference to, among other things, whether the untrue
     statement or alleged untrue statement of a material fact or omission or
     alleged omission relates to information supplied by the Company or by the
     Underwriters and the parties' relative intent, knowledge, access to
     information and opportunity to correct or prevent such statement or
     omission. The amount paid or payable by a party as a result of the losses,
     damages, expenses, liabilities and claims referred to in this subsection
     shall be deemed to include any legal or other fees or expenses reasonably
     incurred by such party in connection with investigating, preparing to
     defend or defending any Proceeding.

          (e)  The Company and the Underwriters agree that it would not be just
     and equitable if contribution pursuant to this Section 10 were determined
     by pro rata allocation (even if the Underwriters were treated as one entity
     for such purpose) or by any other method of allocation that does not take
     account of the equitable considerations referred to in subsection (c)
     above. Notwithstanding the provisions of this Section 10, no Underwriter
     shall be required to contribute any amount in excess of the amount by which
     the total price at which the Shares underwritten by such Underwriter and
     distributed to the public were offered to the public exceeds the amount of
     any damage which such Underwriter has otherwise been required to pay by
     reason of such untrue statement or alleged untrue statement or omission or
     alleged omission. No person guilty of fraudulent misrepresentation (within
     the meaning of Section 11(f) of the Act) shall be entitled to contribution
     from any person who was not guilty of such fraudulent misrepresentation.
     The Underwriters' obligations to contribute pursuant to this Section 10 are
     several in proportion to their respective underwriting commitments and not
     joint.

          (f)  The indemnity and contribution agreements contained in this
     Section 10 and the covenants, warranties and representations of the Company
     contained in this Agreement shall remain in full force and effect
     regardless of any investigation made by or on behalf of any Underwriter,
     its partners, directors or officers or any person (including each partner,
     officer or director of such person) who controls any Underwriter within the
     meaning of Section 15 of the Act or Section 20 of the Exchange Act, or by
     or on behalf of the Company its directors or officers or any person who
     controls the Company within the meaning of Section 15 of the Act or Section
     20 of the Exchange Act, and shall survive any termination of this Agreement
     or the issuance and delivery of the Shares. The Company and each
     Underwriter agree promptly to notify each other of the commencement of any
     Proceeding against it and, in the case of the Company, against any of the
     Company's officers or directors in connection with the issuance and sale of
     the Shares, or in connection with the Registration Statement or Prospectus.

          11.  Notices. Except as otherwise herein provided, all statements,
               -------
requests, notices and agreements shall be in writing or by telegram and, if to
the Underwriters, shall be sufficient in all respects if delivered or sent to
UBS Warburg LLC, 299 Park Avenue, New York, New York 10171-0026, Attention:
Syndicate Department and, if to the Company, shall be sufficient

                                       26
<PAGE>

in all respects if delivered or sent to the Company at the offices of the
Company at 860 Atlantic Avenue, Alameda, California 94501, Attention: [       ].

          12.  Governing Law; Construction. This Agreement and any claim,
               ---------------------------
counterclaim or dispute of any kind or nature whatsoever arising out of or in
any way relating to this Agreement ("Claim"), directly or indirectly, shall be
                                     -----
governed by, and construed in accordance with, the laws of the State of New
York. The section headings in this Agreement have been inserted as a matter of
convenience of reference and are not a part of this Agreement.

          13.  Submission to Jurisdiction. Except as set forth below, no Claim
               --------------------------
may be commenced, prosecuted or continued in any court other than the courts of
the State of New York located in the City and County of New York or in the
United States District Court for the Southern District of New York, which courts
shall have jurisdiction over the adjudication of such matters, and the Company
consents to the jurisdiction of such courts and personal service with respect
thereto. The Company hereby consents to personal jurisdiction, service and venue
in any court in which any Claim arising out of or in any way relating to this
Agreement is brought by any third party against UBSW or any indemnified party.
Each of UBSW and the Company (on their respective behalfs and, to the extent
permitted by applicable law, on behalf of their respective stockholders and
affiliates) waives all right to trial by jury in any action, proceeding or
counterclaim (whether based upon contract, tort or otherwise) in any way arising
out of or relating to this Agreement. The Company agrees that a final judgment
in any such action, proceeding or counterclaim brought in any such court shall
be conclusive and binding upon the Company and may be enforced in any other
courts in the jurisdiction of which the Company is or may be subject, by suit
upon such judgment.

          14.  Parties at Interest. The Agreement herein set forth has been and
               -------------------
is made solely for the benefit of the Underwriters and the Company and to the
extent provided in Section 10 hereof the controlling persons, directors and
officers referred to in such section, and their respective successors, assigns,
heirs, personal representatives and executors and administrators. No other
person, partnership, association or corporation (including a purchaser, as such
purchaser, from any of the Underwriters) shall acquire or have any right under
or by virtue of this Agreement.

          15.  Counterparts. This Agreement may be signed by the parties in one
               ------------
or more counterparts which together shall constitute one and the same agreement
among the parties.

          16.  Successors and Assigns. This Agreement shall be binding upon the
               ----------------------
Underwriters, the Company and their successors and assigns and any successor or
assign of any substantial portion of the Company's, and any of the Underwriters'
respective businesses and/or assets.

          17.  Miscellaneous. UBSW, an indirect, wholly owned subsidiary of UBS
               -------------
AG, is not a bank and is separate from any affiliated bank, including any U.S.
branch or agency of UBS AG. Because UBSW is a separately incorporated entity, it
is solely responsible for its own contractual obligations and commitments,
including obligations with respect to sales and purchases of securities.
Securities sold, offered or recommended by UBSW are not deposits, are

                                       27
<PAGE>

not insured by the Federal Deposit Insurance Corporation, are not guaranteed by
a branch or agency, and are not otherwise an obligation or responsibility of a
branch or agency.

          A lending affiliate of UBSW may have lending relationships with
issuers of securities underwritten or privately placed by UBSW. To the extent
required under the securities laws, prospectuses and other disclosure documents
for securities underwritten or privately placed by UBSW will disclose the
existence of any such lending relationships and whether the proceeds of the
issue will be used to repay debts owed to affiliates of UBSW.

                                       28
<PAGE>

          If the foregoing correctly sets forth the understanding among the
Company and the Underwriters, please so indicate in the space provided below for
the purpose, whereupon this letter and your acceptance shall constitute a
binding agreement among the Company and the Underwriters, severally.

                                   Very truly yours,

                                   XENOGEN CORPORATION

                                   By: _____________________________
                                       Name:
                                       Title:


Accepted and agreed to as of the
  date first above written, on behalf of
  themselves and the other several Underwriters
  named in Schedule A
           ----------


UBS WARBURG LLC
CIBC WORLD MARKETS CORP.
DAIN RAUSCHER INCORPORATED

By: UBS WARBURG LLC


By: _____________________________
    Name:
    Title:


By: _____________________________
    Name:
    Title:

                                       29
<PAGE>

                                  SCHEDULE A


                                                                   Number of
Underwriter                                                       Firm Shares
-----------                                                       -----------

UBS Warburg LLC................................................
CIBC World Markets Corp........................................
Dain Rauscher Incorporated.....................................
                                                                  -----------
   Total.......................................................     7,000,000
                                                                  ===========

                                       30


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