ORASURE TECHNOLOGIES INC
8-K, EX-16, 2000-12-21
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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December 21, 2000


Securities and Exchange Commission
450 Fifth Street, NW
Washington, D.C. 20549


Commissioners:

We have read the  statements  made by OraSure  Technologies,  Inc. (the Company)
(copy attached), which we understand will be filed with the Commission, pursuant
to Item 4 of Form 8-K, as part of the Company's  Form 8-K report dated  December
21, 2000. We agree with the statements concerning our Firm in such Form 8-K.

Very truly yours,

/s/ PricewaterhouseCoopers LLP

PricewaterhouseCoopers LLP


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