ORASURE TECHNOLOGIES INC
S-8, EX-5, 2000-10-26
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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MILLER NASH LLP                                      Miller Nash LLP
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                                October 25, 2000


OraSure Technologies, Inc.
8505 S.W. Creekside Place
Beaverton, Oregon 97008

             Subject:   OraSure  Technologies,  Inc.  Registration  Statement on
                        Form S-8

Ladies and Gentlemen:

            Reference  is  made  to  the  registration  statement  on  Form  S-8
("Registration Statement") to be filed by OraSure Technologies, Inc., a Delaware
corporation (the "Corporation"), with the Securities and Exchange Commission for
the purpose of registering under the Securities Act of 1933, as amended, 440,997
shares (the "Registered  Shares") of the  Corporation's  common stock, par value
$.000001 per share,  to be issued  under the OraSure  Technologies,  Inc.  Stock
Purchase Plan (the "Plan").

            We  have  examined  originals  or  copies,  certified  or  otherwise
identified to our  satisfaction,  of such  corporate  records,  certificates  of
public officials, and other documents as we have deemed necessary or relevant as
a basis for the opinion set forth herein.

            Based on the foregoing, it is our opinion that:

                  1.    The Plan has  been  duly  adopted  and  approved  by all
necessary corporate action.

                  2.  When the  Registered  Shares  are  issued  and sold by the
Corporation  as  provided  in the  Plan  while  the  Registration  Statement  is
effective,  and when  payment  for such  shares to the  extent and in the manner
required by the Plan is received by the Corporation,  the Registered Shares will
be legally issued, fully paid and non-assessable.

<PAGE>

OraSure Technologies, Inc.           - 2 -                      October 25, 2000



            We consent to the use of this opinion in the Registration  Statement
and in any amendments  thereof.  In giving this consent, we do not thereby admit
that we are in the category of persons whose consent is required under Section 7
of the Securities Act.


                                       Very truly yours,

                                       /s/ MILLER NASH LLP






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