GEMINI GENOMICS PLC
F-1/A, EX-2.2, 2000-07-20
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                     Exhibit 2.2

                       SALE OF SHARES AND CLAIMS AGREEMENT

                                     between

                               GEMINI HOLDINGS PLC

                                       and

                              THE MAJORITY VENDORS

                Confidential Treatment Requested and the Redacted
                Material has been separately filed with the Commission
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                                                                           2(28)


                                TABLE OF CONTENTS

1   PARTIES .............................................................  3

2   PREAMBLE ............................................................  3

3   DEFINITIONS AND INTERPRETATIONS .....................................  3

4   SALE AND PURCHASE OF THE MINORITY SHARES AND THE MINORITY CLAIMS ....  8

5   PURCHASE PRICE ......................................................  8

6   CLOSING .............................................................  8

7   REPRESENTATIONS AND WARRANTIES OF THE MAJORITY VENDORS ..............  9

8   REPRESENTATIONS AND WARRANTIES BY THE PURCHASER ..................... 20

9   INDEMNIFICATION ..................................................... 21

10  FURTHER ASURANCE .................................................... 23

11  CONFIDENTIALITY; ANNOUNCEMENTS ...................................... 23

12  ASSIGNMENT .......................................................... 24

13  NOTICES ............................................................. 24

14  AMENDMENTS .......................................................... 25

15  HEADINGS ............................................................ 25

16  ANNULMENT OF PROVISIONS ............................................. 26

17  MISCELLANEOUS ....................................................... 26

18  CONDITIONS PRECEDENT ................................................ 27

19  GOVERNING LAW AND ARBITRATION PROCEDURES ............................ 27
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                       SALE OF SHARES AND CLAIMS AGREEMENT

1       PARTIES

1.1     Gemini Holdings Plc, registered in England with number 3377251, whose
        registered office is at 162, Science Park, Milton Road, Cambridge CB4
        OGH, United Kingdom, hereinafter referred to as the "Purchaser".

1.2     The persons and entities listed in Appendix 1 hereto, hereinafter
        collectively referred to as the "Minority Vendors".

2       PREAMBLE

2.1     The Majority and the Minority Vendors are the owners of all of the
        Shares in and have the benefit of all of the Claims against Eurona
        Medical AB, co. reg no 556512-6298, a company incorporated under the
        laws of Sweden (hereinafter referred to as the "Company"), having a
        registered share capital of SEK 1,045,232 divided into 1,045,232 shares
        with a nominal value of SEK 1 each.

2.2     The Purchaser has agreed to purchase and the Majority Vendor have agreed
        to sell the Majority Shares and the Majority Claims on the terms and
        conditions set out in this Agreement.

3       DEFINITIONS AND INTERPRETATIONS

3.1     In this Agreement (including the Appendices hereto) the following terms
        and expressions shall have the meanings set out below:

"Accounting Principles"         means the accounting principles described in
                                Appendix 2 hereto, and otherwise such principles
                                as are consistent with the past practice of the
                                Company during the years 1997, 1998 and 1999,
                                all such principles being in accordance with
                                generally accepted accounting principles in
                                Sweden;

"Accounts"                      means the audited statutory balance sheet and
                                the audited profit and loss account of the
                                Company for the financial year ended 31
                                December, 1998, prepared in accordance with the
                                Accounting Principles;

"Agreement"                     means this Sale of Shares and Claims Agreement,
                                together with all Appendices
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                                hereto;

"Agreement on Purchase and      means an agreement on purchase and licensing of
Licensing of Inventions"        cardiovascular intellectual property entered
                                into by the Company and Pyrosequencing AB on
                                December 6, 1999;

"Appendix; Appendices"          means the Appendices to this Agreement;

"Balance Sheet"                 means the Balance Sheet of the Company as of the
                                Balance Sheet Date enclosed as Appendix 3;

"Balance Sheet Date"            means 30 November, 1999;

"Claims"                        means all claims and rights of whatsoever nature
                                and however arising which any of the Vendors may
                                have against the Company on the Closing Date or
                                at a later date arising out of circumstances
                                present on the Closing Date, including but not
                                limited to (i) any other monetarial claims than
                                wages, employment benefits and consultancy fees,
                                (ii) zero coupon loan notes and promises to
                                receive zero coupon loan notes, (iii) options
                                (including but not limited to synthetic options
                                (sw: "synteriska optioner") and staff options
                                (sw: "personaloptioner"), (iv) warrants, rights,
                                commitments, conversion rights and any other
                                rights to subscribe for or acquire shares in the
                                Company;

"Closing"                       means the consummation and completion of the
                                sale of the Shares and of the benefit of the
                                Claims at the Closing Date in accordance with
                                the provisions of clause 5 below;

"Closing Date"                  means 17 December, 1999;

"Directors"                     means the board members and deputy board members
                                of the Company at the Closing Date;

"Due Diligence List"            means a list of the documents disclosed to the
                                Purchaser by the Vendors, as set out in Appendix
                                4 hereto;
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"Environment"                   means any and all organisms (including man),
                                ecosystems, property and the following media:
                                air (including the air within buildings and the
                                air within other natural or man-made structures,
                                whether above or below ground); water (including
                                water under or within land or in drains or
                                sewers and coastal and inland waters); and land
                                (including land under water);

"Environmental Laws"            means any and all laws, whether civil, criminal
                                or administrative, applicable to the Company
                                and/or conduct of the Company's business and
                                which have as a purpose or effect the protection
                                or the provision of remedies in respect of the
                                Environment including: European Community or
                                European Union regulations, directives,
                                decisions and recommendations; statutes and
                                subordinate legislation; regulations, orders and
                                ordinances; Permits; codes of practice,
                                circulars, guidance notes and the like; common
                                law, local laws and by-laws; and judgements,
                                notices. orders, directions, instructions or
                                awards of any competent authority;

"Gemini Shareholders            means the Shareholders Agreement relating to
Agreement"                      Phenomix PLC entered into between GeneLink
                                Holdings Limited and others, on the one side,
                                and Phenomix PLC on the other side, on December
                                5, 1997.

"Health and Safety Laws"        means any and all laws, whether civil, criminal
                                or administrative, applicable to the Company
                                and/or the Company's business concerning health
                                and safety matters and all and any regulations
                                or orders made or issued under any such
                                legislation and any relevant codes of practice,
                                guidance notes and the like issued by government
                                agencies;

"Intellectual Property"         means all domestic and foreign patents, patent
                                applications, patent licenses, software rights
                                and Know-How rights, trade names, trademarks,
                                copyrights, service marks, trademark
                                registration and
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                                                                           6(28)


                                applications (whether pending or abandoned),
                                service mark registrations and applications,
                                copyright registrations and applications
                                (whether pending or abandoned), rights to
                                drawings and photographs, and rights to patterns
                                as well as any other intellectual property of
                                any nature;

"IT Systems"                    means any and all computer, telecommunications
                                and network equipment and/or computer software
                                or programs (in both source and object code
                                form) of whatsoever nature owned or used by the
                                Company;

"Know-How"                      means all information, data and methodology
                                nor at present freely available to the public
                                and all financial, commercial, trade and
                                business secrets of whatever nature and in
                                whatever form (including those comprised in,
                                derived from or relating to any drawings,
                                diagrams, illustrations, data,
                                specifications, lists, programs, formulae,
                                technical information, plans, reports,
                                manuals and all other documents, recorded
                                information and data);

"Majority Claims"               means the Claims held by the Majority Vendors
                                as set out opposite the names listed in
                                Appendix 1;

"Majority Shares"               means the Shares held by the Majority Vendors
                                as set out opposite the names listed in
                                Appendix 1;

"Majority Vendors"              means the persons and entities set out in
                                Appendix 1;

"Minority Claims"               means the Claims held by the Minority Vendors
                                as set out opposite the names listed in
                                Appendix 5;

"Minority Shares"               means the Shares held by the Minority Vendors
                                as set out opposite the names listed in
                                Appendix 5;

"Minority Vendors"              means the persons and entities set out in
                                Appendix 5;
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"Permits"                       means any and all licences, consents, permits,
                                registrations, filings, exemptions, approvals,
                                authorisations or the like, made or issued
                                pursuant to or under, or required by,
                                Environment Laws in relation to the carrying on
                                of the Company's business;

"Properties"                    means the premises leased by the Company in
                                accordance with the lease agreements listed in
                                Appendix 6;

"Purchase Price"                means the price set out in clause 5 below;

"Relevant IP"                   means the Intellectual Property owned, used or
                                exploited by the Company and listed in Appendix
                                7;

"Shares"                        means 1,045,232 shares in the Company each with
                                a nominal value of SEK 1;

"To the best knowledge of the   means matters which are actually known
Majority Vendor"                by any of the Majority Vendors or any
                                board member or deputy board member of
                                the Company appointed by any Majority
                                Vendor;

"Warranties"                    means the warranties and representations set out
                                in clause 7 below;

"Value 1"                       means (i) the quoted price [trading
                                bid price] (SW: KOPKURS) of each
                                Majority Vendor's Gemini Shares at
                                the date occurring two (2) trading
                                days after a claim for
                                indemnification is made in
                                accordance with clause 9, or (ii) if a
                                Majority Vendor has disposed of his Gemini
                                Shares before a claim is made, the purchase
                                price; or (iii) if the Majority Vendor has
                                partially disposed of his Gemini Shares before a
                                claim is made, the aggregate of (i) and (ii);

"Value II"                      means the purchase price actually received by
                                each Majority Vendor for his Gemini Shares at
                                a sale made in accordance with the Gemini
                                Shareholders Agreement and the Purchasers
                                articles of association;

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"Vendors"                       means the Majority Vendors and the
                                Minority Vendors collectively

4       SALE AND PURCHASE OF THE MAJORITY SHARES AND THE MAJORITY CLAIMS

4.1     Subject to the terms of this Agreement, each of the Majority Vendors
        agree to sell to the Purchaser the number of the Majority Shares and the
        benefit of the Majority Claims as set out opposite each Majority
        Vendor's name in Appendix 1 on the Closing Date and the Purchaser agrees
        to purchase the Majority Shares and the benefit of the Majority Claims
        on the same date.

4.2     The Majority Shares and the benefit of the Majority Claims shall be sold
        free from liens and encumbrances and together with all benefits and
        rights attaching thereto.

4.3     The Purchaser shall not be obliged to complete the purchase of any of
        the Shares or the benefit of any of the Claims union the purchase of all
        of the Shares and of the benefit of all of the Claims is completed
        simultaneously.

5       PURCHASE PRICE

        The Purchase Price for the Majority Shares and the benefit of the
        Majority Claims shall be satisfied by the issue by the Purchaser of
        eighty six thousand eighty six (86,086) C Preferred Ordinary Shares of
        GBP 1 (one) each in the Purchaser ("the Gemini Shares"), which shall be
        delivered to the Majority Vendors in the proportions set out opposite
        their respective names in Appendix 1.

6       CLOSING

6.1     Closing shall, unless otherwise agreed in writing between the parties,
        take place immediately upon the execution of this Agreement on the
        Closing Date at the offices of CMS Tisell Advokatfirma AB.

6.2     At the Closing

        (i)     each Majority Vendor shall in exchange for the number of Gemini
                Shares set out opposite his name in Appendix 1, deliver to the
                Purchaser the share certificates his respective number of the
                Majority Shares and any instrument pertaining to the Majority
                Claims, all of which shall be duly endorsed;

        (ii)    the Majority Vendors shall cause all Directors to retire (to the
                extent
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                                                                           9(28)


                this is requested by the Purchaser) without any claims for
                compensation from the Company;

        (iii)   if requested by the Purchaser, the Majority Vendors shall
                procure the Company to issue powers of attorney enabling the
                persons appointed by the Purchaser to sign for and on behalf of
                the Company until new signatories have been duly registered.

7       REPRESENTATIONS AND WARRANTIES OF THE MAJORITY VENDORS

        The Majority Vendors represent, warrant and agree as of the Closing Date
        that the following statements in this clause 7 are true and correct in
        all respects.

        The Purchaser has carried out an investigation of the Company (due
        diligence).

        None of the Warranties shall be deemed in any way modified or discharged
        by reason of any investigation or inquiry made or to be made by or on
        behalf of the Purchaser unless information implying a deviation from
        and/or a breach of a Warranty is clearly disclosed in this clause 7
        and/or in the documents contained in the Due Diligence List. No other
        information relating to the Company of which the Purchaser has knowledge
        (actual or constructive) shall prejudice any claim which the Purchaser
        shall be entitled to bring or shall operate to reduce any amount
        recoverable by the Purchaser under this Agreement.

7.1     Capacity

        Each Majority Vendor has obtained all necessary corporate and other
        consents and approvals in relation to the performance of this Agreement
        and, accordingly, has full power to enter into and perform this
        Agreement, which constitutes (or will when executed constitute) binding
        obligations on each Majority Vendor in accordance with its terms.

7.2     Full Disclosure

        The information set out in Appendices 1 - 13 and all information
        contained in the documents listed in the Due Diligence List is true and
        accurate and not misleading and all information which has been given to
        the Purchaser or its representatives or professional advisers by the
        Vendors or by any director, officer or other official of the Company or
        by their respective professional advisers or other agents in the course
        of the negotiations leading to this Agreement was when given and is now
        true and accurate in all respects and not misleading. Insofar as any
        such information are matters of opinion or represent a forecast,
        intention or expectation,
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        such opinions, forecasts, intentions or expectations (as appropriate)
        are honestly held or believed by the Majority Vendors and made on
        reasonable grounds.

        To the best knowledge of the Majority Vendors, there are no undisclosed
        material facts or circumstances concerning the Company, which if
        disclosed to the Purchaser, might reasonably have been expected to
        affect the decision of the Purchaser to enter into this Agreement on the
        terms herein.

7.3     Ownership of Stock

        Each Vendor is the owner of record of the number of Shares as listed
        opposite his name in Appendices 1 and 5 hereto, free and clear of all
        liens, encumbrances, restrictions and claims of any kind; each Majority
        Vendor has full legal right, power and authority to enter into this
        Agreement and to sell, assign, transfer and convey the Shares so owned
        by him pursuant to this Agreement.

7.4     Claims

        Each Vendor is the holder of the Claims listed opposite his name in
        Appendices 1 and 5 hereto, free and clear of all liens, encumbrances and
        claims of any kind; each respective Majority Vendor has full legal
        right, power and authority to enter into this Agreement and to sell,
        assign, transfer, waive and convey the Claims so held by him pursuant to
        this Agreement; each Vendor has no further Claims than the ones listed
        in Appendices 1 and 5.

7.5     The Company

        The Company is a corporation duly formed and organised and is validly
        existing under the laws of Sweden. The Company has the requisite
        corporate power and authority to own its property and to carry on its
        business in its present form. The Company's Articles of Association and
        Certificate of Registration as presently in force are attached as
        Appendix 8 to this Agreement and are true and complete in all respects
        and the Company has always carried on it business and affairs in
        accordance with the Company's Articles of Association and Certificate of
        Registration.

7.6     Share Capital

        The Shares constitute the whole of the Company's share capital and each
        Vendor is the sole beneficial owner of the number of Shares as set out
        opposite his name in Appendices 1 and 5. All such outstanding Shares
        have been duly authorised and validly issued and are fully paid and
        non-assessable, and have not been issued in violation of any pre-emptive
        rights of shareholders. There are no outstanding options, zero coupon
        loan notes,
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                                                                          11(28)


        warrants, rights, calls, commitments, conversion rights, rights of
        exchange, plans or other agreements of any character providing for the
        purchase, subscription, allotment, issuance or sale of any shares of the
        capital stock of the Company other than the Claims listed opposite each
        Vendors name in Appendices 1 and 5 hereto.

7.7     Accounts, Balance Sheet and Financing

7.7.1   The Accounts have been properly audited and the Accounts and the Balance
        Sheet are true and correct in all respects and have been prepared in
        accordance with the Accounting Principles. The Accounts and the Balance
        Sheet fairly present the financial condition of the Company at the
        respective dates thereof and, except as indicated therein, reflects all
        claims made against and all debts and liabilities of the Company, fixed
        or contingent, as at the respective dates thereof, and the related
        income statements fairly present the results of operation of the Company
        for the period indicated; and do not include (and the profits of the
        Company for the period have not been affected to a material extent by)
        any unusual, extraordinary or non-recurring items of income or
        expenditure.

7.7.2   The Company's account overdraft facility (sw. "checkrakningskredit") and
        bridging facility, the particulars set out in Appendix 9, are terminated
        by the Company on the Closing Date and all sums owed by the Company
        under said facilities are repaid in full.

7.8     Book and Records

7.8.1   All accounts, books, ledgers and official and other records of the
        Company of whatsoever kind have been properly and accurately kept and
        completed in all material respects, and there are no material
        inaccuracies or discrepancies of any kind contained or reflected
        therein, and taken as a whole they reflect a fair view of the financial
        position of the Company.

7.8.2   To the best knowledge of the Majority Vendors, all returns, particulars,
        resolutions and other documents required to be filed with or delivered
        to the Swedish Patent and Registration Office (sw. "Patent- och
        Registreringsverket") by the Company have been correctly and properly
        prepared and so filed or delivered.

7.9     Assets of the Company

7.9.1   The Company has good, valid and marketable title to all its tangible
        assets and, To the best knowledge of the Majority Vendors, to all its
        intangible assets including, without limitation, all the assets
        reflected in the Accounts and the Balance Sheet except as indicated in
        the notes thereto, and all the assets purchased or otherwise acquired by
        the Company since the Balance

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                                                                          12(28)


        Sheet Date (except in each case for assets reflected in the Accounts and
        the Balance Sheet or acquired since the Balance Sheet Date that have
        been sold or otherwise disposed of in the ordinary course of business)
        and all such assets are in the possession and control of the Company and
        sited within Sweden; in each case subject to no encumbrance, lien,
        charge or other restriction of any kind or character, except for liens
        reflected in the Balance Sheet or the notes thereto.

7.9.2   The Company has not acquired or agreed to acquire any material assets on
        terms that title does not pass to the Company until full payment is made
        (sw. "aganderattsforbehall").

7.9.3   Appendix 10 contains a complete and accurate list of all assets owned or
        in the possession of the Company and held under any leasing,
        hire-purchase, conditional sale, deferred payment or other similar
        agreement and up to date details of the rentals (or alike payments)
        payable by the Company thereunder.

7.10    Contracts

        Complete and accurate copies of all contracts to which the Company is a
        party as are material have been disclosed by the Majority Vendors and
        are listed in the Due Diligence List. The Company is not a party to or
        subject to any agreement, transaction, obligation, commitment,
        understanding, arrangement or liability which is in any way otherwise
        than in the ordinary and proper course of the Company's business.

7.10.1  To the best knowledge of the Majority Vendors, the terms of all
        contracts of the Company have been complied with by the Company and by
        the other parties to the contracts in all material respects and there
        are no circumstances likely to give rise to default by the Company or by
        the other parties under such contracts.

7.10.2  The Majority Vendors have no knowledge of the invalidity,
        unenforceability or grounds of rescission or avoidance of any agreement
        (wholly or partly) or other transactions to which the Company is a party
        and has received no notice of any intention to terminate or disclaim any
        such agreement or other transaction.

7.10.3  The agreement of 14 May, 1998 between the Company and Clinical
        Responsibility in Uppsala AB (formerly Eurona AB) ensures the Company
        the full and unlimited benefit of any and all of Clinical Responsibility
        in Uppsala AB's rights in accordance with the contracts set out in
        Appendix 11.

7.10.4  The Company has the right, at no cost for the Company, to assume the
        rights of Clinical Responsibility in Uppsula AB in accordance with the

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        contracts set out in Appendix 11 and thus to enter into the contract as
        a party, subject to the approval of the counterparty.

7.11    Litigation

        There is no action, suit, proceeding by any person or legal entity, or
        any arbitration or any administrative or other proceeding by or before
        any governmental or other instrumentality or agency, pending or, to the
        best knowledge of the Majority Vendors, threatened, against the Company
        and the Majority Vendors do not know of any valid basis for any such
        action, proceeding or investigation. The Company is not plaintiff in any
        proceeding or in any arbitration or administration proceeding. The
        Company is not subject to any judgement, order or decree entered in any
        lawsuit or proceeding.

7.12    Taxes

7.12.1  The Company has filed, or caused to be filed within the times and within
        the manner prescribed by law, all tax or information returns and tax
        reports required under all applicable statutes, rules or regulations to
        be filed by the Company with respect to any taxes, levies and charges
        (including interest, penalties or additions to tax in respect of the
        foregoing) whether disputed or not (all of the foregoing and the tax
        losses referred to in sub-clause 7.12.2 collectively referred to as
        "Taxes"). All Taxes shown on said returns to be due and all additional
        assessments received prior to the date hereof have been paid. The
        amounts set up as accruals for Taxes in the Accounts and the Balance
        Sheet are sufficient for the payment of all accrued and unpaid Taxes of
        the Company whether or not disputed, for all periods ended on and prior
        to the respective dates thereof. The Company has not received notice of
        any proposed audit or reassessment from any taxing authorities and no
        examination by the appropriate taxing authority of any return of the
        Company is currently in progress. No deficiency in the payment of Taxes
        by the Company for any period has been asserted by any authority and
        remains unsettled at Closing Date. There are no outstanding agreements
        or waivers extending the statutory period of limitation for assessment
        applicable to any tax return of the Company.

7.12.2  The tax losses for the fiscal year 1999 will amount to not less than SEK
        sixty five million six hundred thousand (65,600,000). The consummation
        of this Agreement will not negatively affect the Company's right to
        deduct the said tax losses.

7.13    Insurance

        To the best knowledge of the Majority Vendors, particulars of all
        policies of insurance of the Company now in force have been disclosed
        and such particulars are true and correct and all premiums due on such
        policies have

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                                                                          14(28)


        been duly paid and all such policies are valid and in force and listed
        in the Due Diligence List. So far as the Majority Vendors are aware
        there are no circumstances which might lead to any liability under such
        insurance being avoided by the insurers or the premium being abnormally
        increased. There is no claim outstanding under any such policies and so
        far as the Majority Vendors are aware there are no circumstances likely
        to give rise to a claim.

7.14    Intellectual Property and Information Technology

7.14.1  Appendix 7 contains complete particulars of all Relevant IP, except for
        patent application reference OE985USO where a license agreement with the
        inventors is not at place.

7.14.2  The Company is the sole beneficial owner of all Relevant IP unless
        otherwise explicitly stated in Appendix 7.

7.14.3  The Company has not, to the best knowledge of the Majority Vendors,
        authorised or otherwise permitted any use whatsoever of any Relevant IP,
        or granted to any third party any right or interest in respect thereof,
        and the Relevant IP owned by the Company is free of all liens, pledges
        or other encumbrances, except for patent application reference 1DO42US1
        and 2D042WO0.

7.14.4  The Relevant IP (insofar as it is owned by the Company) is valid and
        subsisting and none of the Relevant IP is, except for patent application
        reference 1DO42US1 and 2D042W00, to the best knowledge of the Majority
        Vendors, the subject of outstanding or threatened disputes, claims or
        proceedings for cancellation, revocation, opposition, interference,
        rectification or contested ownership.

7.14.5  In carrying on its business, the Company has, except for patent
        application reference 1DO42US1 and 2D042WO0, to the best knowledge of
        the Majority Vendors, not infringed and does not infringe any
        Intellectual Property of a third party.

7.14.6  Where registration is available, applications for registration of all
        Relevant IP owned by the Company are, to the Best knowledge of the
        Majority Vendors, being diligently prosecuted and the Company has,
        except for patent application reference 1DO42US1 and 2D042WO0, received
        no adverse opinion whether from any registry concerned or its own
        advisers in relation to any such application. All pending patent
        applications have been maintained and all fees have been paid on time.

7.14.7  To the best knowledge of the Majority Vendors all Know-How owned, used
        or exploited by the Company has been kept secret and confidential and
        has not been disclosed to third parties other than those subject to
        confidentiality obligations and there has, except as set out in Appendix
        7,
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                                                                          15(28)


        been no publication of research results detrimental to the application
        of patents.

7.14.8  To the best knowledge of the Majority Vendors, all agreements or
        arrangements relating to the Relevant IP are valid, binding and
        enforceable, none has been the subject of any breach or default by any
        party or of any event which with notice or lapse of time or both would
        constitute a default, and there are no disputes, claims or proceedings
        arising out of or relating to such agreements or arrangements.

7.14.9  To the best knowledge of the Majority Vendors, there has been and is no
        current or anticipated infringement by any third party of any Relevant
        IP.

7.14.10 All material IT Systems are owned or leased by the Company.

7.14.11 Appendix 7 contains a complete listing of all agreements or arrangements
        with third parties relating to IT Systems, which are material to the
        Business (including all hire purchase agreements, or leases of hardware
        and licences of software, disaster recovery services, outsourcing or
        consultancy agreements, maintenance and support contracts) and all such
        agreements and arrangements are valid, binding and enforceable.

7.14.12 The Company has fulfilled its obligations under the Swedish Act on the
        Right to Employee Inventions (sw: "lag om ratten till arbetstagares
        uppfinning") in relation to T. Norberg, M. Andersson and F. Lindstrom
        (re: patent applications reference 1DO42US1 and 2D042WO0) and to T.
        Norberg, M. Andersson, L. Jonsson and P. Lindstrom (re: patent
        applications reference 1E793US1 and 2E793WO0.

7.15    Compliance with Laws; Licenses and Permits

7.15.1  Compliance

        To the best knowledge of the Majority Vendors, the Company is, and its
        business has been conducted, in compliance in all material respects with
        all applicable laws, regulations, orders, judgements, decrees, codes,
        and ordinances (hereinafter referred to as "Requirements of Law"). The
        Company has not been charged with or threatened with, or is under any
        investigation with respect to any charge concerning any violation of
        any Requirements of Law.

7.15.2  Licenses

        To the best knowledge of the Majority Vendors, the Company has all
        licenses, permits or other governmental certificates, authorisations and
        approvals required by any governmental or regulatory body for the
        operation of the Company's business or the use of its properties as
        presently
<PAGE>

                                                                          16(28)


        operated or used.

7.16    Employees

7.16.1  Appendix 12 is a complete and accurate schedule of all employees of the
        Company including details of their dates of birth, the date on which
        they commenced continuous employment with the Company and all
        remuneration payable and other benefits provided or which the Company is
        bound to provide to each such person. In addition, the Due Diligence
        List contains a complete listing of all standard terms of employment and
        other statements or documents containing the terms of employee
        emoluments and benefits.

7.16.2  All employees of the Company, except for the administrative staff not
        involved in research and development, have confirmed the Company's
        rights to inventions an accordance with the appendix: "Rights to
        Inventions" (sw: "Ratt till uppfinningar") attached to each employment
        agreement.

7.16.3  The Due Diligence List contains a complete listing of all consultancy
        agreement of any significance for the normal course of the Company's
        business (including management services agreements) in existence between
        the Company and any other person, firm or company, and there are no
        arrangements (including collective bargaining agreements) between the
        Company or any employers association of which the Company as a member
        and any trade union.

7.16.4  The Company will not be encumbered with any consultancy, costs related
        to the disposal of the Shares and Claims to the Purchaser, including but
        not limited to fees to financial and legal advisors.

7.16.5  Save to the extent (if any) to which provision or allowance has been
        made in the Accounts or the Balance Sheet the Company has not, except
        for what is evident from any disclosed employment contract, made or
        agreed to make any payment to or provided or agreed to provide any
        benefit for any former director, officer or employee of the Company.

7.16.6  To the best knowledge of the Majority Vendors, the Company has, with the
        exception for the termination of Erik Bisessar's employment and the
        Purchaser's disclosure to certain of the Company's staff of its
        intentions regarding reduction in staff levels complied with all
        obligations imposed on it by all relevant statutes, regulations and
        codes of conducts and practice relating to its employees and (so far
        as relevant) former employees and has maintained current and adequate
        records regarding the service, terms and conditions of employment of
        each of its employees.

7.16.7  Save as provided in Appendix 12, no present director, officer or
        employee of the Company has given or received notice terminating his
        employment

<PAGE>

                                                                          17(28)


        except as expressly contemplated under this Agreement and the
        consummation of this Agreement will not entitle any employee to
        terminate his employment or trigger any entitlement to a severance
        payment or liquidated damages.

7.16.8  Save for the Claims listed in Appendices 1 and 5 the Company does not
        have in existence nor is it proposing to introduce, and none of its
        directors, officers and employees participates in (whether or not
        established by the Company), any employee share trust, share incentive
        scheme, share option scheme or profit sharing scheme for the benefit of
        all or any of its present or former directors, officers or employees or
        the persons closely associated with any of such persons or any scheme
        under which any present or former director, officer or employee of the
        Company is entitled to a commission or remuneration of any other sort
        calculated by reference to the whole or past of the turnover, profits or
        sales of the Company or any other person, firm or company.

7.16.9  The Company is not involved in any labour dispute, no dispute exists
        between the Company and any trade union or employee, and to the best
        knowledge of the Majority Vendors, there are no wage or other claims
        outstanding against the Company by any person who is now or has been a
        director, officer or employee of the Company, other than the claims
        raised by Per Lindstrom.

7.17    Post-Balance Sheet Date Events

7.17.1  Since the Balance Sheet Date, the Company:

        (i) has carried on its business in the normal course and without any
        interruption or material alterations in the nature, scope or manner of
        its business;

        (ii) has, except for the Agreement on Purchasing and Licensing of
        Inventions, not acquired or disposed of or agreed to acquire or dispose
        of any assets other than in the ordinary course of trading, or assumed
        or incurred or agreed to assume or incur any material liabilities
        (actual or contingent) or entered into any long term or unusual
        transaction, whether or not in the ordinary course of trading;

        (iii) has not declared, made or paid any dividend, bonus or other
        distribution of capital or income;

        (iv) has not received or been notified of any wage claim or made or
        agreed to make any change to the terms of employment or basis or amount
        of the emoluments or pension benefits to any present or former director,
        officer or employee of the Company, except for a payment to Torbjorn
        Norberg in accordance with the agreement regarding synthetic options,
        Appendix 3;

<PAGE>

                                                                          18(28)


        (v) has not entered into any contract involving capital expenditures;

        (vi) has not purchased stock in quantities or at prices materially
        greater than was the practice of the Company before the Balance Sheet
        Date;

        (vii) has not acquired or agreed to acquire any asset for a
        consideration higher than the market value at the time of acquisition of
        such asset or disposed of or agreed to dispose of any asset for a
        consideration lower than the market value of such asset at the time of
        disposal;

        (viii) has paid its creditors within the times agreed with such
        creditors and does not have any debts outstanding which are overdue for
        payment by more than four weeks; and

        (ix) has not made a payment or incurred an obligation to make a payment
        which will not be deductible in computing trading profits for the
        purposes of corporation tax.

7.18    Net assets

        The net assets (sw: "eget kapital") of the Company on Closing Date is at
        least SEK thirty five million seven hundred thousand (35,700,000) of
        which at least SEK one million five hundred thousand (1,500,000) is in
        unrestricted cash and cash equivalents. The total net assets of the
        Company on Closing Date shall be determined in accordance with the
        Accounting Principles.

7.19    Liabilities

        To the best knowledge of the Majority Vendors, there an no actual or
        contingent liabilities arising out of contract (including tort and
        product liability) due to the activities and products of the Company.

7.20    Properties

7.20.1  The Properties comprise all the premises leased, controlled, used or
        occupied by the Company.

7.20.2  The Company has no liability (whether actual, contingent or otherwise)
        as lessee, assignee, guarantor, covenantor or otherwise arising from or
        relating to any estate, interest or right in any land other than the
        Properties.

7.20.3  The Company is in actual occupation of the Properties on an exclusive
        basis and besides the lessor (sw; "hyresvarden") (to the extent
        prescribed by law or the Lease Agreement) no person, other than the
        Company, has any right (actual or contingent) to possession, occupation
        or use of or interest in the Properties.
<PAGE>

                                                                          19(28)


7.20.4  Complete and accurate copies of all lease agreements are enclosed hereto
        in Appendix 6 (hereinafter collectively referred to as the "Lease
        Agreements") and the Company has not committed any material breach
        thereof.

7.20.5  The sub lease agreement regarding certain premises at Kungsangsvagen 25
        in Uppsala between Clinical Responsibility in Uppsala AB as sub lessor
        and the Company as sub lessee (hereinafter referred to as the "Sub Lease
        Agreement") is amended on the Closing Date to the effect that the
        Company's rights and obligations under the Sub Lease Agreement are
        identical with and/or not less favourable than the terms set out in
        Clinical Responsibility in Uppsala AB's lease agreement with the owner
        of the property on which the premises are located. The owner of the
        premises has approved the sub lease in accordance with the Sub Lease
        Agreement.

7.20.6  Except for charges for utility services the Properties are not subject
        to any other outgoings than those set out in the Lease Agreements and
        sums due under the Lease Agreements and payments for utility services
        have bean made to date.

7.20.7  To the best knowledge of the Majority Vendors, there is no outstanding
        order, notice or other requirement of any local or other authority
        affecting the Properties or involving expenditure in compliance with it,
        nor any circumstances which may result in any such order or notice being
        made or served.

7.20.8  To the best knowledge of the Majority Vendors, the Company has complied
        in all material respects with all laws, regulations, restrictions,
        covenants and obligations (including all covenants binding the Company
        contained in the Lease Agreements) relating to the Properties, the
        Company has not received any notice or allegation of any breach of such
        laws, regulations, restrictions, covenants or obligations from any
        person and there are no circumstances likely to give rise to the service
        of any such notice or allegation.

7.21    Environment, Health and Safety

7.21.1  To the best knowledge of the Majority Vendors, the Properties have been
        used and the Company's business has been conducted at all times in
        compliance with Environmental Laws and Health and Safety Laws.

7.21.2  To the best knowledge of the Majority Vendors, no material work,
        repairs, remedy, construction, or capital expenditure is or may be
        required under any Environmental Laws and/or Health and Safety Laws or
        in order to carry on lawfully the Company's business.

7.21.3  To the best knowledge of the Majority Vendors all Permits have been
        obtained and are in full force and effect and their terms and conditions
        have been complied with.
<PAGE>

                                                                          20(28)


7.21.4  To the best knowledge of the Majority Vendors, no circumstance exists
        which may or is liable to result to the detriment of the Company in
        modification, suspension, or revocation of any Permit or may or is
        likely to result in any such Permit not being extended, renewed, granted
        or (where necessary) transferred.

7.21.5  To the best knowledge of the Majority Vendors, no hazardous matter is or
        has been generated, used, kept, treated, transported, spilled,
        deposited, disposed of, discharged, emitted or otherwise dealt with or
        managed at, on, under or from any of the Properties.

7.21.6  To the best knowledge of the Majority Vendors, the Company has not
        received any notice, claim, demand or other communication alleging any
        actual or potential breach of Environmental Laws or Health and Safety
        Laws from any applicable authority or individual and the Majority
        Vendors are not aware of any circumstances that might reasonably be
        expected to give rise to the service of any such notice, claim, demand
        or communication.

7.22    Insolvency

        The Company has not stopped payment of its debt (sw; "betalningsin-
        stallelse"), has not entered into any scheme of arrangement or voluntary
        arrangement with any of its creditors except for the settlement of the
        Claims in accordance with this Agreement; then is no pending application
        for bankruptcy or winding-up of the Company and there is no distress,
        execution or other process levied on any of the Company's assets.

8       REPRESENTATIONS AND WARRANTIES BY THE PURCHASER

8.1     At the next annual general shareholders meeting of the Company, the
        Purchaser undertakes to grant the Directors who have retired during
        1999, discharge from liability for their administration until the
        Closing Date (or the earlier date of retirement), however, subject that
        the auditor's reports for the relevant periods do not recommend against
        such discharge.

8.2     The Purchaser is duly organised and existing under the laws of the
        United Kingdom and is in compliance with its articles of association.

8.3     The Purchaser has obtained all necessary corporate and other consents
        and approvals in relation to the performance of this Agreement and,
        accordingly, has full power to enter into and perform this Agreement,
        which constitutes (or will when executed constitute) binding obligations
        on the Purchaser in accordance with its terms.

8.4     The Purchaser is acquiring the Shares for its own account and has no
        present
<PAGE>

                                                                          21(28)


        intention of disposing of same.

9       INDEMNIFICATION

9.1     In the event of a deviation from and/or a breach of any of the
        Warranties, the Majority Vendors shall severally and not jointly pay to
        the Purchaser on a pro rata basis to each Majority Vendors consideration
        in accordance with clause 5, the aggregate of:

9.1.1   the full amount by which the value of any asset or contract of the
        Company (including any asset or contract warranted to exist which does
        not exist) is or becomes less than it would have been if the Warranties
        had not been breached or untrue or misleading;

9.1.2   an amount equal to any other loss or liability suffered or incurred by
        the Purchaser and/or the Company as a result of any Warranty being
        breached or untrue or misleading; and

9.1.3   all costs, expenses and disbursements incurred by the Purchaser and/or
        the Company as a result of any Warranty being breached or untrue or
        misleading.

9.1.4   Irrespective of the above in sub-clause 9.1, the Majority Vendor's
        aggregate liability due to a deviation from and/or breach of the
        Warranty in sub-clause 7.12.2 shall be limited to SEK three million
        nine hunderd thousand (3,900,000).

9.2     With respect to an indemnity to be paid pursuant to sub-clause 9.1
        hereof:

9.2.1   No amount shall be payable unless the aggregate of compensation under
        the Warranties exceed SEK 800,000 but upon exceeding such amount, the
        entire amount of the claims from the first SEK shall be payable. This
        does not apply to any indemnity to be paid pursuant to sub-clause 9.1
        hereof in case of a deviation from and/or a breach of any of the
        Warranties in sub-clauses 7.6, 7.12.2, 7.16.4 and 7.18, which shall be
        indemnified from the first SEK;

9.2.2   The indemnity to be paid by each Majority Vendor (exclusive of any legal
        fees or court costs) shall not exceed the lower sum of

        (i)     SEK twenty nine million three hundred and seventy two thousand
                (29,372,000) distributed between each of the Majority vendors
                on a pro rata basis to each Majority Vendor's consideration in
                accordance with clause 5; or

        (ii)    if the Purchaser is quoted on a stock exchange when a claim is
                made:

<PAGE>

                                                                          22(28)


                Value I; or

        (iii)   if the Purchaser is not quoted on a stock exchange when a claim
                is made: Value II.

        For avoidance of doubt it should he clarified that each Majority
        Vendor's indemnity shall be limited to each Majority Vendor's portion of
        the consideration in accordance with clause 5.

9.3     No claim may be brought by the Purchaser against the Majority Vendors
        unless notice in writing of any such claim, accompanied by reasonable
        particulars thereof specifying the nature of the breach giving rise to
        the claim and, so far as practicable, the amount claimed in respect
        thereof, has been given to the Majority Vendors not later than twelve
        (12) months after the Closing Date, and, in the case of a claim relating
        to Warranties of a tax nature, not later than ninety (90) days from the
        date the Taxes have been finally determined by the relevant tax
        authority or tax court. The Purchaser is under no obligation to bring
        claims under the Warranties against the Majority Vendors at any time
        before the expiry of the twelve month period.

9.4     A breach of this Agreement which is capable of remedy shall not entitle
        the Purchaser to compensation unless the Majority Vendors are given
        written notice of such breach and such breach is not fully remedied
        within sixty (60)days after the date on which such notice is served on
        the Majority Vendors.

9.5     If the Majority Vendors shall pay an amount to the Purchaser (or shall
        procure the payment of an amount to the Purchaser) in respect of a
        deviation from and/or a breach of a Warranty and the Purchaser or the
        Company subsequently recovers or becomes entitled to recover (whether by
        way of payment, discount, credit, set of, counterclaim or otherwise)
        from a third party (including any taxation authority) a sum which is
        referable to that breach, the Purchaser shall notify the Majority
        Vendors and, if so directed by them, the Purchaser shall procure that
        the Company shall take all necessary reasonable steps to enforce such
        recovery and the Purchaser shall forthwith repay to the Majority Vendors
        so much of the amount so paid to the Purchaser as shall not exceed the
        sum recovered from the third party, less all reasonable costs charges
        and expenses incurred by the Purchaser or the Company (as the case may
        be) in obtaining that payment and in recovering that sum from the third
        party. If no recovery is made, the Majority Vendors shall reimburse the
        Purchaser or the Company (as the case may be) all reasonable costs,
        charges and expenses incurred in seeking to obtain recovery.

9.6     Any liability of the Majority Vendors under this Agreement shall be
        computed after taking into account and giving credit for any
        corresponding tax saving before the expiry of the fiscal year 2002.
        However, such a tax
<PAGE>

                                                                          23(28)


        saving shall only be credited if the tax losses referred to in
        sub-clause 7.12.2 have been fully utilised before the expiry of the
        fiscal year 2002. If any provision (whether for taxation or any other
        matter) in the Accounts or the Balance Sheet shall prove to be an
        over-provision, the amount over-provided shall be set off against the
        liability (if any) of the Major Vendors under this Agreement.

10      FURTHER ASSURANCE

10.1    The Majority Vendors shall, from time to time on being required to do so
        by the Purchaser, promptly and at the cost and expense of the Majority
        Vendors do or procure the doing of all such acts and/or execute or
        procure the execution of all such documents in a form satisfactory to
        the Purchaser as the Purchaser may reasonably consider necessary for
        giving full effect to this Agreement (or to such parts of it as remain
        operative after termination) and securing to the Purchaser the full
        benefit of the rights, powers and remedies conferred upon the Purchaser
        in this Agreement.

11      CONFIDENTIALITY; ANNOUNCEMENTS

11.1    The Majority Vendors severally undertake with the Purchaser, and the
        Purchaser undertakes with the Majority Vendors, to keep confidential
        (except as expressly provided in this Agreement) at all times after the
        date of this Agreement, and not directly or indirectly reveal, disclose
        or use for his or its own or any other purposes, any confidential
        information received or obtained as a result of entering into or
        performing, or supplied by or on behalf of a party in the negotiations
        leading to, this Agreement and which relates to:

11.1.1  the negotiations relating to this Agreement;

11.1.2  the subject matter and/or provisions of this Agreement; or

11.1.3  (in the Majority Vendors' case) the Purchaser or (in the Purchaser's
        case) the Majority Vendors.

11.2    The Prohibition in sub-clause 11.1 does not apply if:

11.2.1  the information was in the public domain before it was furnished to the
        relevant party or, after it was furnished to that party, entered the
        public domain otherwise than as a result of (i) a breach by that party
        of this clause or (ii) a breach of a confidentiality obligation by the
        discloser, where the breach was known to that party; or
<PAGE>

                                                                          24(28)


11.2.2  disclosure as necessary in order to comply with applicable legislation,
        regulatory requirements or to obtain tax or other clearances or consents
        from any relevant taxation authority; or

        provided that any such information disclosable pursuant to sub-clause
        11.2.2 shall be disclosed (unless such consultation is prohibited by
        applicable law or regulatory requirements) only after consultation with
        the Purchaser or the Majority Vendors (as the case may be).

11.3    No party shall make any press release or other public announcement in
        connection with any of the transactions contemplated by this Agreement
        except:

11.3.1  an announcement in the agreed form or in any other form agreed by the
        Purchaser and the Majority Vendors; or

11.3.2  any announcement required by any applicable law or regulatory
        requirements to which the party is subject (including the London Stock
        Exchange Limited).

12      ASSIGNMENT

12.1    The Purchaser is permitted to assign the benefit of, and any of its
        rights under, this Agreement without restrictions.

12.2    None of the Majority Vendors may assign, transfer, charge or deal in any
        way with the benefit of, or any of their respective rights under or
        interest in, this Agreement except in accordance with a prior written
        waiver given by the Purchaser.

13      NOTICES

13.1    Any communication to be given in connection with the matters
        contemplated by this Agreement shall be in writing and shall either be
        delivered by hand or sent by registered mail (sw: "rekommenderat brev")
        or facsimile transmission. Delivery by courier shall be regarded as
        delivery by hand. Such communication shall be sent to the address or the
        facsimile number of the relevant party set out below or to such other
        address or facsimile number as may previously have been communicated to
        the sending party in accordance with this clause.
<PAGE>

                                                                          25(28)


        Majority Vendors               Purchaser

        To the addresses set           To the company secretary of the Purchaser
        out opposite each Majority
        Vendors name in                FAX: +44 1223 43 53 01
        Appendix 13

        Provided further that the Purchaser may serve any such communication on
        the Majority Vendors by service on any of the Majority Vendor.

13.2    A communication shall be deemed to have been served:

13.2.1  if delivered by hand at the address referred to above at the time of
        delivery;

13.2.2  if sent by registered mail to the address referred to in that
        sub-clause, at the expiration of two days after the time of posting; and

13.2.3  if sent by facsimile to the number referred to in that sub-clause, at
        the time of completion of transmission by the sender.

13.3    In proving service of the communication, it shall be sufficient to show
        that delivery by hand was made or that the envelope containing the
        communication was properly addressed and posted as a registered mail or
        that the facsimile was dispatched and a confirmatory transmission report
        received.

13.4    A Party may notify the other Parties of a change to its name, address or
        facsimile number for the purposes of sub-clause 13.1 provided that such
        notification shall only be effective on the date specified in the
        notification as the date on which the change is to take place or if no
        date is specified or the date specified is less than five days after the
        date on which notice is deemed to have been served. the date falling
        five days after notice of any such change as deemed to have been given.

14      AMENDMENTS

        Amendments to this Agreement must be in writing and signed by the
        Parties to be binding.

15      HEADINGS

        The division of the Agreement into different clauses and the inclusion
        of headings will not affect the interpretation of this Agreement.
<PAGE>

                                                                          26(28)


16      ANNULMENT OF PROVISIONS

        If any provision in this Agreement or part thereof is declared null and
        void, the Agreement as a whole will not be annulled as long as the
        Agreement remains significant without the annulled provision or part. If
        an annulment significantly affects one party's benefits from or
        performance based on this Agreement, a party that considers itself
        disadvantaged is entitled to initiate negotiations with the other
        parties with the aim of restoring the balance of the Agreement through
        reasonable modification of other provisions in the Agreement.

17      MISCELLANEOUS

17.1    By the signing of this Agreement each Majority Vendor confirms his
        adherence to the Gemini Shareholders Agreement and that they shall vote
        in any meeting of the Purchaser's shareholders in accordance with the
        current majority of shareholders in the Purchaser. Furthermore, each
        Majority Vendor confirms that the Eurona Shareholders' Agreement entered
        into between Per Lindstrom, Torbjorn Schroder, Lars Frodell, Goran
        Agerberg, Bismuth Investments Ltd and Health Cap KB dated 19 March 1997
        is immediately terminated without retaining rights for any of the
        parties thereto.

17.2    Should the Purchaser not acquire all the Shares on the Closing Date and
        the Purchaser notwithstanding this chooses to refrain from using his
        right to cancel this Agreement, the Purchaser will be unable to hold an
        extraordinary general meeting immediately after Closing and appoint a
        new board of director in the Company. In such case each Majority Vendor
        shall use his best endeavours to see to it that the board directors
        appointed by him remain as board members in the Company until the
        Purchaser are able to appoint a new board of directors.

17.3    Upon Closing of this Agreement, the Company will give a general power of
        attorney to officers of the Purchaser. Under the circumstances set out
        in the first sentence a sub-clause 17.2, each Majority Vendor shall use
        his best endeavours to see to it that the board directors appointed by
        him do not participate in any decisions or act on behalf of the Company
        without the prior consent of the Purchaser or the holders of the general
        power of attorney. Each Majority Vendor shall also use his best
        endeavours to see to it that the board directors appointed by him
        participate in decisions and act on behalf of the Company in accordance
        with the instructions of the Purchaser and the holders of the general
        power of attorney. The foregoing shall under no circumstances result in
        a board director appointed by a Majority Vendor not being able to fulfil
        his fiduciary obligations against the Company or result in his
        participation in decisions and acts on behalf of the Company in conflict
        with the Swedish companies Act (Sw: Aktiebolagslagen)
<PAGE>

                                                                          27(28)


        Upon request of a Majority Vendor, the Purchaser shall furnish an
        indemnity to the board directors appointed by the Majority Vendor for
        the damages that may occur from following instructions from the
        Purchaser and the holders of the general power of attorney.

18      CONDITION PRECEDENT

        This Agreement as conditional upon

        (i)     each Majority Vendor fulfilling his obligations according to
                clause 6;

        (ii)    the purchase by the Purchaser of the Minority Shares and all the
                benefits of the Minority Claims is completed on the Closing
                Date;

        (iii)   the Company on the Closing Date having entered into the
                Agreement on Purchase and Licensing of Inventions; and

        (iv)    the Purchaser and the shareholders of Clinical Responsibility in
                Uppsala AB having entered into an option agreement giving the
                Purchaser the right but not the obligation to purchase all the
                shares in Clinical Responsibility in Uppsala AB (including any
                right to subscribe for, acquire or otherwise receive shares) for
                a purchase price equal to the par value of the shares. The
                option shall be exercised within (twelve) 12 months from the
                Closing Date.

        If any of these conditions is not satisfied, the Purchaser is entitled
        to cancel this Agreement in relation to all of the Majority Vendors,
        without any liability of any kind for the Purchaser.

19      GOVERNING LAW AND ARBITRATION PROCEDURES

19.1    This Agreement is governed by the substantive laws of Sweden.

19.2    Any dispute, controversy or claim arising out of or in connection with
        this Agreement, or the breach, termination or invalidity thereof, shall
        be finally settled by arbitration in accordance with the Rules of the
        Arbitration Institute of the Stockholm Chamber of Commerce.

        The arbitral tribunal shall be composed of three (3) arbitrators
        appointed by the Stockholm Chamber of Commerce.

        The place of arbitration shall be Stockholm.

        The language to be used in the arbitral proceedings shall be English.

                       ---------------------------------
<PAGE>

                                                                          28(28)


The parties have executed this Agreement with Appendices 1 - 13 as of this date
in six (6) original copies, of which each of the parties have taken one each.


December 12, 1999                       [ILLEGIBLE] Dec 17 99
-------------------------               ---------------------------
(Place and date)                        (Place and date)


                                        BISMUTH INVESTMENTS
GEMINI HOLDINGS PLC                     (GIBRALTAR) LTD


/s/ [ILLEGIBLE]                         /s/ [ILLEGIBLE]
-------------------------               ---------------------------


                                        [ILLEGIBLE] Dec 17, 99
                                        ---------------------------
                                        (Place and date)


                                        HEALTHCAP KB


                                        /s/ Eugen Steiner
                                        ---------------------------
                                        Eugen Steiner


                                        [ILLEGIBLE] Dec 17, 99
                                        ---------------------------
                                        (Place and date)


                                        SETRACO AB


                                        /s/ [ILLEGIBLE]
                                        ---------------------------


                                        Stockholm Dec 17, 1999
                                        ---------------------------
                                        (Place and date)


                                        /s/ Per Lindstrom
                                        ---------------------------
                                        Per Lindstrom


                                        Stockholm Dec 17, 1999
                                        ---------------------------
                                        (Place and date)


                                        /s/ Torbjorn Schroder
                                        ---------------------------
                                        Torbjorn Schroder



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