BIOQUEST INTERNATIONAL INC
SB-2, EX-10.12, 2000-09-26
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                                                                   EXHIBIT 10.12











                           WARRANT AGREMEMENT BETWEEN
                          BIOQUEST INTERNATIONAL, INC.
                                       AND
                            DUNCAN, BLUM & ASSOCIATES









<PAGE>



Securities Counsel Warrant Certificate No.  _________            15,000 Warrants



         VOID AFTER THREE YEARS AFTER THE IPO IS REGISTERED WITH THE SEC

                       WARRANT CERTIFICATE FOR PURCHASE OF
                   15,000 BIOQUEST INTERNATIONAL, INC. SHARES
                                 OF COMMON STOCK


THIS  WARRANT AND ANY SHARES  AGENT  ISSUABLE  UPON ITS  EXERCISE  HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933 AND MAY NOT BE TRANSFERRED UNTIL (1)
A REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 (THE "ACT") SHALL HAVE
BECOME EFFECTIVE WITH RESPECT THERETO OR (2) RECEIPT BY THE ISSUER OF AN OPINION
OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER TO THE EFFECT THAT REGISTRATION
UNDER THE ACT IS NOT REQUIRED IN CONNECTION  WITH SUCH PROPOSED  TRANSFER NOR IS
SUCH TRANSFER IN VIOLATION OF ANY APPLICABLE STATE SECURITIES LAWS.


     This certifies that FOR VALUE RECEIVED,  Carl Duncan or registered  assigns
(the  "Registered  Holder") is the owner of the number of Warrants  ("Warrants")
specified  above.  Each  Warrant  initially  entitles the  Registered  Holder to
purchase,  subject  to the terms and  conditions  set forth in Section 1 of this
Warrant  Certificate  15,000  shares of common  stock of BioQuest  International
Inc.,  a  Virginia  corporation  (the  "Company"),  at any time  commencing  the
Effectiveness  Date and prior to the Expiration Date (as  hereinafter  defined),
upon  the  presentation  and  surrender  of this  Warrant  Certificate  with the
Subscription  Form on the reverse hereof duly executed,  at the corporate office
of the Company as the initial  Warrant Agent or its  successor,  accompanied  by
payment of an amount equal to $0.01 for each Warrant (the  "Purchase  Price") in
lawful  money of the United  States of America  in cash or by  official  bank or
certified check made payable to BioQuest International, Inc. The Company may, at
its election, reduce the Purchase Price.

     Each  Warrant  represented  hereby  is  exercisable  at the  option  of the
Registered  Holder,  but no fractional Shares will be issued. In the case of the
exercise of less than all the Warrants  represented  hereby,  the Company  shall
cancel this Warrant  Certificate upon the surrender hereof and shall execute and
deliver a new Warrant  Certificate or Warrant  Certificates of like tenor, which
the Warrant Agent shall countersign, for the balance of such Warrants.

     The term  "Expiration  Date"  shall mean 5:00 P.M.  Eastern  Standard  Time
("EST") three years after the IPO is registered with the SEC. If such date shall
in the  Commonwealth  of  Virginia  be a holiday or a day on which the banks are
authorized to close,  then the Expiration Date shall mean 5:00 P.M. EST the next
following  day which in the State of New York is not a holiday or a day on which
banks are  authorized  to close.  The Company may, at its  election,  extend the
Expiration Date.

     This Warrant Certificate is exchangeable,  upon the surrender hereof by the
Registered  Holder at the  corporate  office  of the  Warrant  Agent,  for a new
Warrant Certificate or Warrant  Certificates of like tenor representing an equal
aggregate number of Warrants, each of such new Warrant Certificates to represent
such number of Warrants as shall be designated by such Registered  Holder at the
time of such surrender.  Upon due presentment with any tax or other governmental
charge imposed in connection  therewith,  for  registration  of transfer of this
Warrant  Certificate  at such  office,  a new  Warrant  Certificate  or  Warrant
Certificates  representing an equal aggregate  number of Warrants will be issued
to the transferee in exchange therefore,  subject to the limitations provided in
the Warrant Agreement.

     Prior to the exercise of any Warrant  represented  hereby,  the  Registered
Holder  shall  not be  entitled  to any of the  rights of a  Shareholder  of the
Company including, without limitation, the right to vote or to receive dividends
or other  distributions,  and shall not be entitled to receive any notice of any
proceedings of the Company.

<PAGE>

     Prior to due presentment for registration of transfer  hereof,  the Company
may deem and treat the  Registered  Holder as the  absolute  owner hereof and of
each Warrant represented hereby  (notwithstanding  any notations of ownership or
writing  hereon  made by anyone  other  than a duly  authorized  officer  of the
Company)  for all  purposes  and  shall  not be  affected  by any  notice to the
contrary.

     Warrants   represented  by  this  Warrant  Certificate  shall  possess  the
following rights:

1.   Exchange of Warrants.

     In the event of a  possible  exchange  of the  Shares of the  Company  into
common stock and/or subsequent public  offering(s) of the Company's  securities,
the  provisions  of  Section  2 hereof  will  govern  in  certain  circumstances
described therein.

2.   Adjustment of Exercise Price and Number of Shares or Warrants.

     (a) Subject to the  exceptions  referred to in Section  2(e) below,  in the
event the Company shall, at any time or from time to time after the date hereof,
sell any Shares for a consideration  per share less than the current fair market
value per share of the Common  Stock on the date of the sale or issue any Shares
as a dividend or distribution to the Shareholders of the Company or subdivide or
combine the  outstanding  Shares into a greater or lesser  number of Shares (any
such sale, issuance, subdivision or combination being herein called a "Change of
Shares"),  then, and thereafter upon each further Change of Shares, the Purchase
Price in effect immediately prior to such Change of Shares shall be changed to a
price  (including any applicable  fraction of a cent)  determined by multiplying
the  Purchase  Price in effect  immediately  prior  thereto by a  fraction,  the
numerator  of  which  shall  be the  sum of the  number  of  Shares  outstanding
immediately  prior to the issuance of such additional Shares and the denominator
of which shall be the sum of the number of Shares outstanding  immediately after
the  issuance  of  such  additional  Shares.   Such  adjustment  shall  be  made
successively whenever such an issuance is made.

     Upon each  adjustment  of the  Purchase  Price,  the total number of Shares
purchasable  upon the exercise of each Warrant shall  (subject to the provisions
contained in Section 2(b)  hereof) be such number of Shares  (calculated  to the
nearest  tenth)  purchasable  at the Purchase  Price  immediately  prior to such
adjustment  multiplied  by a  fraction,  the  numerator  of  which  shall be the
Purchase  Price  in  effect   immediately  prior  to  such  adjustment  and  the
denominator  of which shall be the Purchase  Price in effect  immediately  after
such adjustment.

     The number of Shares outstanding at any given time shall not include Shares
owned or held by or for the  account of the  Company and the sale or issuance of
such treasury  Shares or the  distribution of any such treasury Shares shall not
be considered a Change of Shares for purposes of said sections.

     (b) In case of any reclassification, capital reorganization or other change
of outstanding  Shares or in case of any  consolidation or merger of the Company
with or into another  corporation (other than a consolidation or merger in which
the  Company  is the  continuing  corporation  and which  does not result in any
reclassification,  capital reorganization or other change of outstanding Shares)
or in case of any sale or conveyance to another  corporation  of the property of
the Company as or  substantially  as, an entirety (other than a  sale/leaseback,
mortgage or other  financing  transaction),  the Company  shall cause  effective
provision  to be made so that each holder of a Warrant  then  outstanding  shall
have the right thereafter,  by exercising such Warrant, to purchase the kind and
number of shares of stock,  Shares or other  securities  or property  (including
cash) receivable upon such  reclassification,  capital  reorganization  or other
change,  consolidation,  merger, sale or conveyance by a holder of the number of
Shares that might have been purchased upon exercise of such Warrant  immediately
prior  to  such  reclassification,   capital  reorganization  or  other  change,
consolidation,  merger,  sale or conveyance.  Any such  provision  shall include
provision  for  adjustments  that  shall  be as  nearly  equivalent  as  may  be
practicable  to the  adjustments  provided for in this Section 2. The  foregoing
provisions  shall  similarly  apply  to  successive  reclassifications,  capital
reorganizations  and other  changes  of  outstanding  Shares  and to  successive
consolidations, mergers, sales or conveyances.

     (c) Irrespective of any adjustments or changes in the Purchase Price or the
number  of  Shares  purchasable  upon  exercise  of the  Warrants,  the  Warrant
Certificates  theretofore  and  thereafter  issued shall continue to express the
Purchase Price per share and the number of Shares purchasable  thereunder as the
Purchase Price per share, and the number of Shares purchasable were expressed in
the Warrant Certificates when the same were originally issued.

<PAGE>

     (d) After each adjustment of the Purchase Price pursuant to this Section 2,
the  Company  will  promptly  prepare a  certificate  signed by the  Chairman or
President of the Company  setting forth:  (i) the Purchase Price as so adjusted;
(ii) the number of Shares  purchasable  upon exercise of each Warrant after such
adjustment  and,  if the  Company  shall  have  elected  to adjust the number of
Warrants,  the number of Warrants to which the registered holder of each Warrant
shall then be entitled;  and (iii) a brief statement of the facts accounting for
such  adjustment.  The Company  will  promptly  file such  certificate  with the
Warrant  Agent and cause a brief  summary  thereof to be sent by ordinary  first
class mail to each registered holder of Warrants at his last address as it shall
appear on the  registry  books of the  Warrant  Agent.  No  failure to mail such
notice  nor any  defect  therein  or in the  mailing  thereof  shall  affect the
validity thereof except as to the holder to whom the Company failed to mail such
notice or except as to the holder whose notice was  defective.  The affidavit of
an officer of the Company that such notice has been mailed shall, in the absence
of fraud, be prima facie evidence of the facts stated therein.

     (e) No adjustment to the Purchase Price of the Warrants or to the number of
Shares  purchasable  upon the  exercise  of each  Warrant  will be made upon the
re-capitalization contemplated in the Memorandum to be effected on or before the
final closing of the offering contemplated therein (the "Offering").

     (f) As used in this Section 2, the term "Shares" shall mean and include the
Company's Shares authorized on the date of the Memorandum and shall also include
any Shares  thereafter  authorized  which shall not be limited to a fixed sum or
percentage in respect of the rights of the holders (the "Shareholders")  thereof
to participate in dividends and in the distribution of assets upon the voluntary
liquidation, dissolution or winding up of the Company.

     (g) Any  determination as to whether an adjustment in the Purchase Price in
effect  hereunder  is required  pursuant to Section 2 or as to the amount of any
such adjustment,  if required, shall be binding upon the holders of the Warrants
and the Company if made in good faith by the Company.

     (h)  If  and  whenever  the  Company   shall   declare  any   dividends  or
distributions  or grant to the  Shareholders,  as such,  rights or  warrants  to
subscribe  for or to  purchase or any options  for the  purchase  of,  Shares or
securities  convertible into or exchangeable for or carrying a right, warrant or
option to purchase Shares,  the Company shall notify each of the then Registered
Holders of the  Warrants  of such event prior to its  occurrence  to enable such
Registered Holders to exercise their Warrants and participate as Shareholders in
such event.

3.   Cashless Exercise of Warrants.

     At any time  during the  Warrant  Exercise  Term,  the Holder  may,  at its
option, exchange this Warrant, in whole or in part (a "Warrant Exchange"),  into
Warrant  Certificate by surrendering this Warrant at the principal office of the
Company,  accompanied  by a notice  stating such Holder's  intent to effect such
exchange,  the number of Shares to be exchanged and the date on which the Holder
requests  that such  Warrant  Exchange  occur (the  "Notice of  Exchange").  The
Warrant  Exchange  shall  take  place on the date  specified  in the  Notice  of
Exchange  or, if later,  within five (5) days of the date the Notice of Exchange
is received by the Company (the "Exchange  Date").  Certificates  for the shares
issuable upon such Warrant  Exchange and, if  applicable,  a new warrant of like
tenor  evidencing the balance of the shares  remaining  subject to this warrant,
shall be issued as of the Exchange Date and delivered to the Holder within three
(3) business days  following the Exchange  Date. In connection  with any Warrant
Exchange,  this Warrant  shall  represent the right to subscribe for and acquire
the number of shares  (rounded  to the next  highest  integer)  equal to (1) the
number of shares  specified by the Holder in its Notice of Exchange  (the "Total
Number")  less (2) the  number  of  Shares  equal to the  quotient  obtained  by
dividing (a) the product of the Total Number and the existing Exercise Price (as
hereinafter  defined)  by (b) the Market  Price of a share of Common  Stock,  as
defined in the next sentence.  As used herein,  the phrase "Market Price" at any
date  shall be deemed  to be the last  reported  sale  price or, in case no such
reported  sale takes place on such day,  the average of the last  reported  sale
prices  for the last three  trading  days,  in either  case as  reported  by the
principal securities exchange on which the Common Stock is listed or admitted to
trading  or as  reported  by  NASDAQ  or if the  Common  Stock is not  listed or
admitted to trading on any national securities exchange or quoted on NASDAQ, the
closing  bid  price on the  NASDAQ  Electronic  Bulletin  Board or as  otherwise
furnished by the National  Association of Securities Dealers,  Inc. (the "NASD")
or similar  organization if the NASD is no longer reporting such information or,

<PAGE>

if no  such  bid  information  is  reported,  as  determined  in good  faith  by
resolution  of  the  Board  of  Directors  of the  Company,  based  on the  best
information available to it for the two days immediately preceding such issuance
or sale and the day of such issuance or sale.

4.   Piggy-Back Registration Rights.

         (a) Subject to (b) below, at any time that the Company proposes to file
a Company  Registration  Statement  under the Securities Act of 1933, as amended
(the "Act") (the  "Registration  Statement"),  either for its own account or for
the  account  of a  stockholder  or  stockholders,  the  Company  shall give the
Placement  Agents  written  notice of its intention to do so and of the intended
method of sale (the "Registration Notice") within a reasonable time prior to the
anticipated filing date of the Company's  Registration  Statement effecting such
Company registration. The Placement Agents may request inclusion of any Warrants
(hereafter "Restricted Securities") in such registration statement by delivering
to the Company,  within ten (10) business days after receipt of the Registration
Notice,  a  written  notice  (the  "Piggyback  Notice")  stating  the  number of
Restricted  Securities  proposed to be  included  and that such shares are to be
included in any underwriting only on the same terms and conditions as the shares
of Common Stock  otherwise  being sold through  underwriters  under such Company
Registration  Statement.  The  Company  shall use its best  efforts to cause all
Restricted  Securities  specified in the Piggyback  Notice to be included in the
Company  Registration  Statement  and any  related  offering,  all to the extent
requisite  to  permit  the  sale  by the  Placement  Agents  of  its  Restricted
Securities in accordance  with the method of sale applicable to the other shares
of Common  Stock  included in such  Company  Registration  Statement;  provided,
however,  that if, at any time after giving  written  notice of its intention to
register  any  securities  and  prior  to the  effective  date  of  the  Company
Registration  Statement filed in connection with such registration,  the Company
shall  determine for any reason not to register or to delay  registration of the
Placement Agents' Restricted Securities,  the Company may, at its election, give
written notice of such determination to the Placement Agents and, thereupon:

         (i) in the ease of a determination  not to register,  shall be relieved
of its  obligation to register the Placement  Agents'  Restricted  Securities in
connection  with  such  registration  (but not from  its  obligation  to pay the
registration expenses in connection therewith); and

         (ii) in the case of a delay in registering, shall be permitted to delay
registering the Placement Agents'  Restricted  Securities for the same period as
the delay in registering such other securities.

     (b)  The  Company's  obligation  to  include  Restricted  Securities  in  a
Company's Registration Statement shall be subject to the following limitations:

         (i) The Company may elect,  at its sole option and for any reason,  not
to register the Placement Agents' Restricted Shares, provided however, that this
right is  limited to one (1) time and  relative  to one (1)  particular  Company
Registration Statement.

         (ii) The  Company  shall not be  obligated  to include  any  Restricted
Securities in a Registration Statement filed on Form S-4, Form S-8 or such other
similar successor forms then in effect under the Securities Act.

         (iii) If a Company  Registration  Statement  involves  an  underwritten
offering and the managing placement agent advises the Company in writing that in
its opinion,  the number of securities  requested to be included in such Company
Registration  Statement  exceeds the number  which can be sold in such  offering
without  adversely  affecting  the  offering,  the Company shall include in such
Company  Registration  Statement the number of such securities which the Company
is so advised  can be sold in such  offering  without  adversely  affecting  the
offering, determined as follows:

                (A) first, the securities proposed by the Company to be sold for
it own account, and

                (B) second, any Restricted  Securities  requested to be included
in such  registration and any other securities of the Company in accordance with
the  priorities,  if and then existing among the holders of such  securities pro
rata among the holders thereof  requesting such registration on the basis of the
number of shares of such securities requested to be included by such holders.

         (iv)  The  Company  shall  not  be  obligated  to  include   Restricted
Securities in more than one (1) Company Registration Statement.

     (c) To the extent the Placement Agents' Restricted  Securities are intended
to be included in a Company  Registration  Statement,  the Placement  Agents may
include any of its Restricted Securities in such Company Registration  Statement
pursuant to this Agreement only if the Placement Agents furnishes to the Company
in writing,  within ten (10) business  days after  receipt of a written  request
therefore,  such  information  specified in Item 507 of Regulation S-K under the
Act or such other  information as the Company may reasonably  request for use in
connection with the Company Registration  Statement or Prospectus or preliminary
Prospectus  included  therein and in any  application to the NASD. The Placement
Agent(s) as to which the Company Registration  Statement is being effected agree
to furnish  promptly to the Company all information  required to be disclosed in
order  to make  all  information  previously  furnished  to the  Company  be not
materially misleading.

     (b) The rights granted herein are non-transferable and may not be exercised
by any  subsequent  holder of the Warrants.  This Warrant  Certificate  shall be
governed by and construed in accordance with the laws of the State of New York.

     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly  executed on  September  18,  2000,  manually by Peter J. Ewens,  its Chief
Executive  Officer,  thereunto duly  authorized and a facsimile of its corporate
seal to be imprinted hereon.


BIOQUEST INTERNATIONAL, INC.


By: /s/ Peter J. Ewens                                            Corporate Seal
    ----------------------------------------
    Peter J. Ewens, Chief Executive Officer



<PAGE>



                                SUBSCRIPTION FORM

                     To Be Executed by the Registered Holder
                          in Order to Exercise Warrants


     The undersigned  Registered  Holder hereby  irrevocably  elects to exercise
Warrants  represented  by this Warrant  Certificate  and purchase the securities
issuable upon the exercise of such Warrants,  and requests that certificates for
such securities shall be issued in the name of (and be delivered to):

            PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER
                                 (if applicable)

                        --------------------------------

                        --------------------------------

                        --------------------------------

                        --------------------------------
                     [Please print or type name and address]


and, if such number of Warrants shall not be all the Warrants  evidenced by this
Warrant  Certificate,  that a new  Warrant  Certificate  for the balance of such
Warrants be registered in the name of, and delivered to, the  Registered  Holder
at the address stated below.

     The  undersigned  represents  that the  exercise of the within  Warrant was
solicited by a member of the National  Association of Securities  Dealers,  Inc.
(the "NASD"). (If not solicited by an NASD member, please write "UNSOLICITED" in
the space below or leave the space blank.)

                        --------------------------------
                              [Name of NASD Member]


Dated:   ________________________________

By:      ________________________________


Signature Guaranteed

--------------------------------


<PAGE>



                                   ASSIGNMENT


                     To Be Executed by the Registered Holder
                           in Order to Assign Warrants


FOR VALUE RECEIVED, ___________________ hereby sells, assigns and transfers unto


            PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER
                                 (if applicable)

                        --------------------------------

                        --------------------------------

                        --------------------------------

                        --------------------------------
                     [Please print or type name and address]


_______________________ of the Warrants represented by this Warrant Certificate,
and       hereby        irrevocably        constitutes        and       appoints
______________________________________________  his lawful  Attorney-in-Fact  to
transfer this Warrant  Certificate on the books of the Company,  with full power
of substitution in the premises.

Dated:   ________________________________

By:      ________________________________


Signature Guaranteed

--------------------------------


THE SIGNATURE TO THE ASSIGNMENT OR THE SUBSCRIPTION  FORM MUST CORRESPOND TO THE
NAME AS WRITTEN UPON THE FACE OF THIS WARRANT  CERTIFICATE IN EVERY  PARTICULAR,
WITHOUT  ALTERATION  OR  ENLARGEMENT  OR ANY  CHANGE  WHATSOEVER,  AND  MUST  BE
GUARANTEED  BY A  COMMERCIAL  BANK OR  TRUST  CONTANY  OR A  MEMBER  FIRM OF THE
AMERICAN, NEW YORK, PACIFIC OR MIDWEST STOCK EXCHANGES.





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