EXHIBIT 4.2


                INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS' CONSENT

         We have issued our report dated October 20, 2000 on the statements of
condition and related securities portfolios of Van Kampen Focus Portfolios,
Series 251 as of October 20, 2000 contained in the Registration Statement on
Form S-6 and Prospectus. We consent to the use of our report in the Registration
Statement and Prospectus and to the use of our name as it appears under the
caption "Other Matters-Independent Certified Public Accountants."



                                                              Grant Thornton LLP

Chicago, Illinois
October 20, 2000



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