BIO RAD LABORATORIES INC
10-K, 1999-03-25
LABORATORY ANALYTICAL INSTRUMENTS
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   <PAGE>

                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C. 20549
                               _________

                               FORM 10-K

   X    ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
        SECURITIES EXCHANGE ACT OF 1934

        For the fiscal year ended December 31, 1998

                              OR

   __   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
        SECURITIES EXCHANGE ACT OF 1934

   For the transition period from _________ to _________________

                     Commission file number  1-7928

                       BIO-RAD LABORATORIES, INC.
          (Exact Name of Registrant as Specified in Its Charter)

            Delaware                                   94-1381833
   (State or Other Jurisdiction of                (I.R.S. Employer
    Incorporation or Organization)                 Identification No.)

    1000 Alfred Nobel Drive, Hercules, CA                  94547
   (Address of Principal Executive Offices)              (Zip Code)

   Registrant's telephone number, including area code (510) 724-7000

   <TABLE>
   Securities registered pursuant to Section 12(b) of the Act:
   <CAPTION>
                                                                                  Market Value on
                                 Name of Each Exchange    Shares Outstanding   March 1, 1999 of Stocks
       Title of Each Class        on Which Registered       March 1, 1999       Held by Non-Affiliates
       -------------------       ---------------------    ------------------   ------------------------
   <S>                          <S>                          <C>                 <C>
   Class A Common Stock
    Par Value $1.00 per share   American Stock Exchange      9,973,679           $157,742,498

   Class B Common Stock
    Par Value $1.00 per share   American Stock Exchange      2,488,899           $  6,756,600

   </TABLE>
   Securities registered pursuant to Section 12(g) of the Act:

                                  NONE

        Indicate by check mark whether the registrant (1) has filed
   all reports required to be filed by Section 13 or 15(d) of the
   Securities Exchange Act of 1934 during the preceding 12 months
   (or for such shorter period that the registrant was required to
   file such reports),  and (2) has been subject to such filing
   requirements for the past 90 days.  Yes  X   No _____

          Indicate by check mark if disclosure of delinquent filers
   pursuant to Item 405 of Regulation S-K is not contained herein,
   and will not be contained, to the best of registrant's knowledge,
   in definitive proxy or information statements incorporated by
   reference in Part III of this Form 10-K or any amendment to this
   Form 10-K.  [ ]

   <PAGE>

                  Documents Incorporated by Reference

            Document                             Form 10-K Parts
   _________________________________________    ____________________
   (1) Annual Report to Stockholders for the
       fiscal year ended December 31, 1998
       (specified portions)                           I, II, IV
   (2) Definitive Proxy Statement to be mailed
       to stockholders in connection with the
       registrant's 1999 Annual Meeting of
       Stockholders (specified portions)                 III

   <PAGE>

                               P A R T  I

   ITEM 1. BUSINESS

   General

   Founded in 1957, Bio-Rad Laboratories, Inc. ("Bio-Rad" or the
   "Company") was initially engaged in the development and produc-
   tion of specialty chemicals used in biochemical, pharmaceutical
   and other life science research applications.  In 1967, the Com-
   pany entered the field of clinical diagnostics with the develop-
   ment of its first test kit based on separation techniques and
   materials developed for life science research.  Recognizing that
   the fields of clinical diagnostics and life science research were
   evolving toward more automated techniques, Bio-Rad expanded into
   the field of analytical and measuring instrument systems through
   internal research and development efforts and acquisitions in the
   late 1970's and 1980's.

   As Bio-Rad broadened its product lines, it also expanded its
   geographical market.  The Company controls its distribution chan-
   nels in twenty-seven countries outside the U.S.A. through
   subsidiaries whose primary focus is customer service and product
   distribution.

   During 1996 and 1997, the Company made five acquisitions.  The
   assets acquired from Chiron Diagnostics Corporation and Chiron
   Corporation on December 5, 1997, enhanced the product line
   offering for diagnostic controls.  The remaining acquisitions
   broadened product line offerings within the Analytical
   Instruments and Life Science segments.  Bio-Rad manufactures and
   supplies the life science research, healthcare, analytical
   chemistry, semiconductor and other markets with a broad range of
   products and systems used to separate complex chemical and
   biological materials and to identify, analyze and purify their
   components.

   Description of Business

   Business Segments

   The Company operates in three industry segments designated Life
   Science, Clinical Diagnostics and Analytical Instruments.  Each
   operates in both the U.S. and international markets.  For a
   description of business and financial information on industry and
   geographic segments, see Note 14 on pages 19 through 22 of
   Exhibit 13.1, which is incorporated herein by reference.  Exhibit
   13.1 is the Company's Consolidated Financial Statements, which is
   an excerpt from the Company's 1998 Annual Report to Stockholders.

   Raw Materials and Components

   The Company utilizes a wide variety of chemicals, biological
   materials, electronic components, machined metal parts, optical
   parts, minicomputers and peripheral devices.  Most of these
   materials and components are available from numerous sources and
   the Company has not experienced difficulty in securing adequate
   supplies.

                                      1
   <PAGE>

   Patents and Trademarks

   The Company owns numerous U.S. and international patents and
   patent licenses.  Bio-Rad believes, however, that its ability to
   develop and manufacture its products depends primarily on its
   know-how, technology and special skills.  Under several patent
   license agreements, Bio-Rad pays royalties on the sales of
   certain products.  Bio-Rad views these patents and license
   agreements as valuable assets, however, no individual agreement
   is of material importance to any segment or to the Company's
   business as a whole.

   Seasonal Operations and Backlog

   The Company's business is not inherently seasonal, however, the
   European custom of concentrating vacation during the summer
   months usually has had a negative impact on third quarter sales
   volume and operating income.

   For the most part, the Company operates in markets characterized
   by short lead times and the absence of significant backlogs.  The
   Company produces several analytical instruments against an order
   backlog.  Management has concluded that backlog information is
   not material to the Company's business as a whole.

   Sales and Marketing

   Each of Bio-Rad's segments maintains a sales force to sell its
   products on a direct basis.  Each sales force is technically
   trained in the disciplines associated with its products.  Sales
   are also generated  through direct mail advertising, exhibits at
   trade shows and technical meetings, telemarketing, and by
   extensive advertising in technical and trade publications.  Sales
   and marketing efforts are augmented by technical service
   departments that assist customers in effective product
   utilization and in new product applications.  Bio-Rad also
   produces and distributes technical literature and holds seminars
   for customers on the use of its products.  The Company maintains
   an internet website, http://www.bio-rad.com, to further enhance
   its marketing efforts.

   Bio-Rad products are sold to a broad and diversified customer
   base.  In 1998, no single customer accounted for as much as 3% of
   Bio-Rad's total sales.  A number of the Company's customers,
   particularly in Life Science, are substantially dependent for
   their funding on government grants and research contracts.  A
   portion of the Analytical Instruments segment is dependent upon
   large semiconductor manufacturers; the loss of these customers or
   a severe downturn in the semiconductor market would have a
   detrimental effect on the results of the segment.

   Most of the Company's international sales are generated by
   wholly-owned subsidiaries and their branch offices in Australia,
   Austria, Belgium, Canada, Denmark, England, Finland, France,
   Germany, Hong Kong, Hungary, India, Israel, Italy, Japan, Korea,
   Mexico, the Netherlands, New Zealand, Norway, People's Republic

                                      2
   <PAGE>

   of China, Poland, Russia, Singapore, Spain, Sweden and
   Switzerland.  Certain of these subsidiaries also have
   manufacturing facilities.  While Bio-Rad's international
   operations are subject to certain risks common to foreign
   operations in general, such as changes in governmental
   regulations, import restrictions and foreign exchange
   fluctuations, the Company's international operations are
   principally in developed nations, which the Company regards as
   presenting no significantly greater risks to its operations than
   are present in the United States.

   Competition

   Most markets served by Bio-Rad's product groups are competitive.
   Bio-Rad's competitors range in size from start-ups to large
   multi-nationals.  Reliable independent information on sales and
   market share of products produced by Bio-Rad's competitors is not
   generally available.  Bio-Rad believes, however, based on its own
   marketing information, that while some competitors are dominant
   with respect to certain individual products, no one company,
   including Bio-Rad, is dominant with respect to a material portion
   of any segment of Bio-Rad's business.

   Product Research and Development

   The Company conducts extensive product research and development
   activities in all areas of its business, employing  approximately
   330 people worldwide in these activities.  Research and
   development have played a major role in Bio-Rad's growth and are
   expected to continue to do so in the future.  New products and
   new applications for existing products are being developed
   continuously by Bio-Rad's researchers.  In its development and
   testing of new products and applications, Bio-Rad consults with
   scientific and medical professionals at universities, hospitals
   and medical schools, and in industry.  Bio-Rad spent
   approximately $41.4 million, $46.1 million and $39.6 million on
   R&D activities during the years ended December 31, 1998, 1997 and
   1996, respectively.

   Regulatory Matters

   Certain of the Company's products (primarily diagnostic products)
   are subject to regulation  in the United States by the Center for
   Devices and Radiological Health of the United States Food and
   Drug Administration (FDA) and in other jurisdictions by state and
   foreign government authorities.  FDA regulations require that
   some new products have pre-marketing approval by the FDA and
   require certain of Bio-Rad's products to be manufactured in
   accordance with "good manufacturing practices," to be extensively
   tested and to be properly labeled to disclose test results and
   performance claims and limitations.

   As a multinational manufacturer and distributor of sophisticated
   instrumentation equipment, Bio-Rad must meet a wide array of
   electromagnetic compatibility and safety compliance requirements
   to satisfy regulations in the United States, the European
   Community and other jurisdictions.  The Company is also subject

                                      3
   <PAGE>

   to government regulation of the use and handling of radioactive
   materials and controlled substances.  The Company believes it is
   in compliance with these and other regulations.

   Certain of the Company's production processes involve the use of
   materials whose use is subject to federal, state and local
   environmental regulations. The Company regularly evaluates its
   processes and procedures to ensure compliance with applicable
   environmental standards and regulations.  Although, from time to
   time, modification of processes and procedures may be required
   which will require additional capital expenditures, the Company
   presently believes that any such expenditures will have no
   material adverse effect on the future results of operations or
   the financial position of the Company.

   Employees

   At December 31, 1998, Bio-Rad had approximately 2,675 full-time
   employees.  Fewer than 7% of Bio-Rad's employees are covered by a
   collective bargaining agreement which will expire on November 7,
   2002.   Bio-Rad considers its employee relations in general to be
   good.

   ITEM 2. PROPERTIES

   Bio-Rad owns its Corporate headquarters located in Hercules,
   California.  The principal manufacturing and research locations
   for each segment are as follows:

     Life Science           Richmond, California        Owned/Leased
                            Hercules, California        Owned
                            Hemel Hempstead, England    Leased
                            Milan, Italy                Leased

     Clinical Diagnostics   Hercules, California        Owned/Leased
                            Irvine, California          Leased
                            Munich, Germany             Leased
                            Nazareth-Eke, Belgium       Leased

     Analytical Instruments Cambridge, Massachusetts    Owned
                            York, England               Owned
                            Philadelphia, Pennsylvania  Owned

   Most manufacturing and research facilities also house
   administration, sales and distribution activities for the
   segment.

   In addition, the Company leases office and warehouse facilities
   in California, Colorado, Florida, New Mexico, Australia, Austria,
   Belgium, Canada, Denmark, England, Finland, France, Germany, Hong
   Kong, Hungary, India, Israel, Italy, Japan, Korea, Mexico, the
   Netherlands, New Zealand, Norway, People's Republic of China,
   Poland, Russia, Singapore, Spain, Sweden and Switzerland.  These
   facilities are used principally for sales, service, distribution
   and administration for all three segments.

                                      4
   <PAGE>

   The Company has leased space in California, New York, Canada and
   England that is not currently being utilized.  For the most part,
   reserves for future lease payments were recorded at the time the
   Company stopped using these facilities.  The Company has
   subleased or is attempting to sublease these properties.

   Life Science segment's northern California distribution and
   instrument manufacturing facility lease expires in November 2000.
   The lease is not automatically renewable at that time.  It is
   anticipated that the distribution and instrument manufacturing
   facility will be moved to a new location in northern California
   prior to November 2000.  All other facilities are believed to be
   adequate to support the Company's current and anticipated
   production requirements.  Historically, adequate space to expand
   sales and distribution channels has been available and is leased
   as needed.

   ITEM 3.  LEGAL PROCEEDINGS

   Note 13, "Legal Proceedings," appearing on page 19 of Exhibit
   13.1 is incorporated herein by reference.

   ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

   There were no matters submitted to a vote of the Company's
   security holders during the fourth quarter of the fiscal year
   covered by this report.

                              P A R T  II

   ITEM 5.  MARKET FOR REGISTRANT'S COMMON STOCK AND RELATED
            STOCKHOLDER MATTERS

   Note 16, "Information Concerning Common Stock," appearing on page
   23 of Exhibit 13.1 is incorporated herein by reference.

   ITEM 6.  SELECTED FINANCIAL DATA

   The table headed "Summary of Operations" appearing on page 1 of
   Exhibit 13.1 is incorporated herein by reference.

   ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
            CONDITION AND RESULTS OF OPERATIONS

   The section headed "Management's Discussion and Analysis of
   Results of Operations and Financial Condition" appearing on pages
   25 through 32 of Exhibit 13.1 is incorporated herein by
   reference.









                                      5
   <PAGE>

   ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET
             RISK

   The section headed "Financial Risk Management" appearing on pages
   31 and 32 of Exhibit 13.1 is incorporated herein by reference.

   ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

   The Report of Independent Public Accountants and the Consolidated
   Financial Statements and Notes thereto appearing on pages 2
   through 24 of Exhibit 13.1 are incorporated herein by reference.

   ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON
           ACCOUNTING AND FINANCIAL DISCLOSURE
   None.

                              P A R T  III

   ITEM 10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

   The sections labeled "Election of Directors" and "Section 16(a)
   Beneficial Ownership Reporting Compliance" of the definitive
   Proxy Statement mailed to stockholders in connection with the
   1999 Annual Meeting of Stockholders (the 1999 Proxy Statement)
   are incorporated herein by reference.

   ITEM 11.  EXECUTIVE COMPENSATION

   The sections labeled "Executive Compensation and Other
   Information," "Compensation of Directors," "Compensation
   Committee Interlocks and Insider Participation," "Report of the
   Compensation Committee of the Board of Directors" and "Stock
   Performance Graph" of the 1999 Proxy Statement are incorporated
   herein by reference.

   ITEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
             MANAGEMENT

   The section labeled "Principal and Management Stockholders" of
   the 1999 Proxy Statement is incorporated herein by reference.

   ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

   The section labeled "Compensation of Directors" of the 1999 Proxy
   Statement is incorporated herein by reference.










                                      6
   <PAGE>

                              P A R T  IV

   ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON
             FORM 8-K

   (a) 1. Index to Financial Statements

          The following Consolidated Financial Statements are
          included in the 1998 Annual Report and are incorporated
          herein by reference pursuant to Item 8:
                                                          Page in
                                                        Exhibit 13.1
          Consolidated Balance Sheets
          at December 31, 1998 and 1997                     2-3

          Consolidated Statements of Income
          for each of the three years in the
          period ended December 31, 1998                    4

          Consolidated Statements of Cash Flows
          for each of the three years in the period
          ended December 31, 1998                           5

          Consolidated Statements of Changes in
          Stockholders' Equity for each of the three
          years in the period ended December 31, 1998       6

          Notes to Consolidated Financial Statements        7-23

          Report of Independent Public Accountants          24

       2. Index to Financial Statement Schedule
                                                         Page in
                                                        Form 10-K

          Schedule II Valuation and Qualifying Accounts     8

          Report of Independent Public Accountants
          on Schedule II                                    9

          All other  financial  statement schedules  are omitted  because
          they are not  required or because  the required information  is
          included in the Consolidated  Financial Statements or the Notes
          thereto.

       3. Index to Exhibits

          The exhibits listed in the accompanying Index to Exhibits on
          pages 11 and 12 of this report are filed or incorporated by
          reference as part of this report.

   (b)  Reports on Form 8-K

   There are no reports on Form 8-K filed by the Company during the last
   quarter of the period covered by this report.

                                      7
   <PAGE>

                            BIO-RAD LABORATORIES, INC.

                 SCHEDULE II -- VALUATION AND QUALIFYING ACCOUNTS

                   Years Ended December 31, 1998, 1997 and 1996

                                  (In thousands)


   <TABLE>
   Reserve for doubtful accounts receivable
   <CAPTION>
                                          Additions
                            Balance at    Charged to                  Balance
                            Beginning     Costs and                   at End
                              of Year      Expenses     Deductions    of Year
                <S>          <C>           <C>           <C>         <C>
                1998         $ 3,374       $ 1,616       $(1,361)    $ 3,629
                              ======        ======        ======      ======

                1997         $ 3,688       $ 1,088       $(1,402)    $ 3,374
                              ======        ======        ======      ======

                1996         $ 3,094       $   952       $  (358)    $ 3,688
                              ======        ======        ======      ======
   </TABLE>





   <TABLE>
   Valuation allowance for deferred tax assets
   <CAPTION>
                                                        Deductions
                            Balance at                  Charged to    Balance
                             Beginning                   Costs and     at End
                             of Year     Additions       Expenses     of Year
                <S>          <C>           <C>           <C>         <C>
                1998         $ 3,285       $ 2,057       $    -      $ 5,342
                               ======        ======        ======      ======

                1997         $ 5,572       $    -        $(2,287)    $ 3,285
                              ======        ======        ======      ======

                1996         $ 6,478       $    -        $  (906)     $5,572
                              ======        ======        ======      ======









                                      8
   <PAGE>

   REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS ON SCHEDULE II


   To the Stockholders and Board of Directors of
   Bio-Rad Laboratories, Inc.:


   We have audited in accordance with generally accepted auditing
   standards, the consolidated financial statements included in
   Bio-Rad Laboratories, Inc.'s annual report to stockholders
   incorporated by reference in this Form 10-K, and have issued our
   report thereon dated February 3, 1999.  Our audit was made for
   the purpose of forming an opinion on those statements taken as a
   whole.  The schedule listed in the index, Item 14(a)2, is the
   responsibility of the Company's management and is presented for
   purposes of complying with the Securities and Exchange
   Commission's rules and is not part of the basic financial
   statements.  This schedule has been subjected to the auditing
   procedures applied in the audit of the basic financial statements
   and, in our opinion, fairly states in all material respects the
   financial data required to be set forth therein in relation to
   the basic financial statements taken as a whole.


                                         /s/ Arthur Andersen LLP
                                             ARTHUR ANDERSEN LLP

   San Francisco, California,
     February 3, 1999



























                                      9
   <PAGE>

                                 SIGNATURES

   Pursuant to the requirements of Section 13 or 15(d) of the Securities
   Exchange Act of 1934, the registrant has duly caused this report to be
   signed on its behalf by the undersigned, thereunto duly authorized.

                                            BIO-RAD LABORATORIES, INC.


                                            By:  /s/ Sanford S. Wadler
                                                  Sanford S. Wadler
                                                      Secretary

                                            Date:   March 25, 1999

   Pursuant to the requirements of the Securities Exchange Act of 1934,
   this report has been signed below by the following persons on behalf
   of the registrant and in the capacities and on the dates indicated.

   Principal Executive Officer:

     /s/  David Schwartz         President and Director    March 25, 1999
        (David Schwartz)

   Principal Financial Officer:

     /s/  T. C. Chesterman       Vice President,           March 25, 1999
        (Thomas C. Chesterman)   Chief Financial Officer

   Principal Accounting Officer:

     /s/  James R. Stark         Corporate Controller      March 25, 1999
        (James R. Stark)

   Other Directors:

     /s/  James J. Bennett       Director                  March 25, 1999
        (James J. Bennett)

     /s/  Albert J. Hillman      Director                  March 25, 1999
        (Albert J. Hillman)

     /s/  Philip L. Padou        Director                  March 25, 1999
        (Philip L. Padou)

     /s/  Alice N. Schwartz      Director                  March 25, 1999
        (Alice N. Schwartz)

     /s/  Norman Schwartz        Director                  March 25, 1999
        (Norman Schwartz)

        _______________________  Director                  March 25, 1999
        (Burton A. Zabin)






                                     10
   <PAGE>

                       BIO-RAD LABORATORIES, INC.
                           INDEX TO EXHIBITS
                              ITEM 14(a)3

   The following documents are filed as part of this report:

   Exhibit No.

   3.1       Restated Certificate of Incorporation, as of
             September 15, 1988. (1)

   3.2       Bylaws of the Registrant, as amended February 19,
             1980. (2)

   10.4      1994 Stock Option Plan. (3)

   10.5      Amended and Restated 1988 Employee Stock Purchase Plan.
             (4)

   10.6      Employees' Deferred Profit Sharing Retirement Plan
             (Amended and Restated effective January 1, 1997). (5)

   10.10     Non-competition and employment continuation agreement
             with James J. Bennett. (6)

   10.11     Employment and non-compete agreement with Dr. Burton A.
             Zabin. (7)

   10.12     Credit Agreement dated as of May 15, 1998, by and among
             the Registrant, the Lenders, and The First National
             Bank of Chicago, as agent. (8)

   10.12.1   Amendment dated as of February 12, 1999, to the Credit
             Agreement dated as of May 15, 1998, by and among the
             Registrant, the Lenders, and The First National Bank of
             Chicago, as agent.

   13.1      Excerpt from Annual Report to Stockholders' for the
             fiscal year ended December 31, 1998, (to be deemed
             filed only to the extent required by the instructions
             to exhibits for reports on Form 10-K).

   21.1      Listing of Subsidiaries.

   23.1      Consent of Independent Public Accountants.

   27.1      Financial Data Schedule.
   ________________________________________________________________

   (1)       Incorporated by reference from the Exhibits to the
             Company's Form 10-K filing for the fiscal year ended
             December 31, 1992, dated March 26, 1993.

   (2)       Incorporated by reference from the Exhibits to the
             Company's Registration Statement on Form S-7
             Registration No. 2-66797, which became effective
             April 22, 1980.



                                     11
   <PAGE>

   (3)       Incorporated by reference from the Exhibits to the
             Company's Form S-8 filing, dated April 28, 1994.

   (4)       Incorporated by reference from the Exhibits to the
             Company's September 30, 1998, Form 10-Q filing dated
             November 10, 1998.

   (5)       Incorporated by reference from the Exhibits to the
             Company's September 30, 1997, Form 10-Q filing dated
             November 13, 1997.

   (6)       Incorporated by reference from the Exhibits to the
             Company's Form 10-K filing for the fiscal year ended
             December 31, 1996, dated March 26, 1997.

   (7)       Incorporated by reference from the Exhibits to the
             Company's June 30, 1997, Form 10-Q filing dated
             August 6, 1997.

   (8)       Incorporated by reference from the Exhibits to the
             Company's June 30, 1998, Form 10-Q filing dated August
             13, 1998.


































                                     12

</TABLE>

   <PAGE>

                                                          EXHIBIT 10.12.1


                FIRST AMENDMENT TO CREDIT AGREEMENT


        THIS FIRST AMENDMENT TO CREDIT AGREEMENT (this "Amendment") is
   made and dated as of the 12 day of February, 1999, by and among THE
   FIRST NATIONAL BANK OF CHICAGO ("FNBC"), UNION BANK OF CALIFORNIA,
   N.A., ABN AMRO BANK N.V., and BANQUE NATIONALE DE PARIS (each of the
   above parties, a "Lender", and collectively, the "Lenders"), FNBC as
   agent for the Lenders (in such capacity, the "Agent"), and BIO-RAD
   LABORATORIES, INC., a Delaware corporation (the "Borrower").

                           RECITALS

        A.   Pursuant to that certain Credit Agreement dated as of May 15,
   1998 among the Agent, the Lenders and the Borrower (as amended to
   date, the "Agreement"), the Lenders agreed to extend credit to the
   Borrower on the terms and subject to the conditions set forth
   therein.  All capitalized terms not otherwise defined herein shall
   have the meanings given to such terms in the Agreement.

        B.   The parties hereto have agreed to certain amendments to the
   Agreement, all as more particularly described below.

        NOW, THEREFORE, in consideration of the foregoing Recitals and
   for other good and valuable consideration, the receipt and adequacy
   of which are hereby acknowledged, the parties hereto hereby agree as
   follows:

                           AGREEMENT

        1. Dividends.  To reflect the agreement of the parties hereto
   to amend the Borrower's covenant on dividends, effective as of the
   First Amendment Effective Date (as defined in Paragraph 3 below),
   Section 6.10 of the Agreement is hereby amended to read in its
   entirety as follows:

        "6.10 Dividends.  The Borrower will not, nor will it permit
        any Subsidiary to, declare or pay any dividends or make any
        distributions on its capital stock (other than (i) dividends
        payable in its own capital stock and (ii) excluding share
        repurchases used solely to fund employee stock purchase plans
        and employee stock option plans, provided such share repurchases
        do not exceed $4,000,000 in any fiscal year (including, without
        limitation, the fiscal year ended December 31, 1998)) or redeem,
        purchase or otherwise acquire or retire any of its capital stock
        at any time outstanding ("Restricted Payments"), except that any
        Subsidiary may declare and pay dividends to the Borrower or to a
        wholly-owned Subsidiary and the Borrower may make Restricted
        Payments in any one fiscal quarter up to an amount not in excess
        of 50% of the sum of consolidated net income during the four
        fiscal quarters ending on the date of determination less any
        Restricted Payments paid during such period, provided that
        during the term of this Agreement the total amount of Restricted
        Payments made shall not exceed $25,000,000 and further, provided

                                      1
   <PAGE>

        no Restricted Payment may be made if prior to, and after giving
        effect thereto, any Default or Unmatured Default exists."

        2. Reaffirmation of Other Loan Documents.  The Borrower hereby
   affirms and agrees that (a) the execution and delivery by the
   Borrower of and the performance of its obligations under this
   Amendment shall not in any way amend, impair, invalidate or otherwise
   affect any of the obligations of the Borrower under the Agreement or
   any other Loan Document, (b) the term "Obligations" as used in the
   Loan Documents include, without limitation, the Obligations of the
   Borrower under the Agreement as amended by this Amendment, and
   (c) except as expressly amended hereby, the Loan Documents remain in
   full force and effect as written.

        3. First Amendment Effective Date.  This Amendment shall be
   effective on the earliest date (the "First Amendment Effective
   Date") upon which the Agent has received (a) duly executed copies of
   this Amendment from each of the Lenders, the Agent and the Borrower,
   and (b) such board resolutions, incumbency certificates and other
   additional documentation as the Agent may request in connection
   herewith.

        4. Representations and Warranties.  The Borrower hereby
   represents and warrants to the Agent and the Lenders as follows:

                (a) The Borrower has the corporate power and authority and
   the legal right to execute, deliver and perform this Amendment and
   has taken all necessary corporate action to authorize the execution,
   delivery and performance of this Amendment.

                (b) This Amendment has been duly executed and delivered on
   behalf of the Borrower and constitutes the legal, valid and binding
   obligation of the Borrower enforceable against the Borrower in
   accordance with its terms.

        5. Counterparts.  This Amendment may be executed in any number
   of counterparts, each of which when so executed shall be deemed to be
   an original and all of which when taken together shall constitute one
   and the same agreement.








                                      2
   <PAGE>

        IN WITNESS WHEREOF, the parties hereto have caused this
   Amendment to be executed as of the day and year first above written.



                                   BIO-RAD LABORATORIES, INC.


                                   By:   /s/ Ronald W. Hutton
                                   Name:     Ronald W. Hutton
                                   Title:    Treasurer



                                   THE FIRST NATIONAL BANK OF CHICAGO,
                                   as the Agent and as a Lender


                                   By:   /s/ Mark A. Isley
                                   Name:     Mark A. Isley
                                   Title:    First Vice President



                                   UNION BANK OF CALIFORNIA, N.A., as a Lender


                                   By:   /s/ Michael E. Cooper
                                   Name:     Michael E. Cooper
                                   Title:    Vice President



                                   ABN AMRO BANK N.V., as a Lender


                                   By:   /s/ Gina M. Brusatori
                                   Name:     Gina M. Brusatori
                                   Title:    Group Vice President


                                   By:   /s/ Dianne D. Barkley
                                   Name:     Dianne D. Barkley
                                   Title:    Group Vice President


                                      3
   <PAGE>



                                   BANQUE NATIONALE DE PARIS, as a Lender


                                   By:   /s/ Debra Wright
                                   Name:     Debra Wright
                                   Title:    Vice President


                                   By:   /s/ Mark McElwain
                                   Name:     Mark McElwain
                                   Title:    Assistant Vice President















                                      4
   la-268130

   <PAGE>

   EXHIBIT 13.1


   Bio-Rad Laboratories, Inc.
   SUMMARY OF OPERATIONS (In thousands, except per share data)
   <TABLE>
   <CAPTION>
   ________________________________________________________________________________________________________________________
                                                                           Year Ended December 31,
                                                         1998        1997        1996        1995        1994       1993
   <S>                                                 <C>         <C>         <C>         <C>         <C>        <C>
   Net sales                                           $441,942    $426,914    $418,789    $396,618    $355,299   $328,553
     Cost of goods sold (1)                             202,438     189,331     182,046     171,942     155,805    151,063
   Gross profit                                         239,504     237,583     236,743     224,676     199,494    177,490

     Selling, general and administrative expense        166,978     164,792     155,516     150,272     132,591    129,187
     Product research and development expense            41,381      46,138      39,580      34,714      30,172     34,204
     Restructuring costs                                      -           -       2,700       1,500           -      3,816

   Income from operations                                31,145      26,653      38,947      38,190      36,731     10,283

   Other income (expense):
     Interest expense                                    (3,731)     (1,216)     (3,027)     (4,465)     (6,138)    (8,406)
     Other, net                                           6,814      (2,709)        553        (183)     (6,596)     2,801

   Income before taxes and extraordinary charge          34,228      22,728      36,473      33,542      23,997      4,678
     Provision for income taxes                           9,926       6,364       9,118       8,386       8,399      1,877

   Income before extraordinary charge                    24,302      16,364      27,355      25,156      15,598      2,801
     Extraordinary charge (2)                                 -           -      (1,176)          -           -          -

   Net income                                          $ 24,302    $ 16,364    $ 26,179    $ 25,156    $ 15,598   $  2,801

   Basic earnings per share before
    extraordinary charge (3)                              $1.98       $1.33       $2.23       $2.06       $1.29      $0.23
     Extraordinary charge (2)(3)                              -           -        (.10)          -           -          -

   Basic earnings per share (3)                           $1.98       $1.33       $2.13       $2.06       $1.29      $0.23

   Weighted average common shares (3)                    12,264      12,260      12,273      12,206      12,113     11,990

   Cash dividends paid per common share                       -           -           -           -           -          -

   Total assets                                        $367,299    $351,876    $284,925    $285,098    $263,650   $259,890

   Long-term debt, net of current maturities           $ 42,339    $ 38,952    $  6,721    $ 20,922    $ 26,287   $ 47,834
   _______________________________________________________________________________________________________________________
   <FN>
   (1) In 1996, cost of goods sold includes a charge of $2.1 million for a write-down of inventory associated with the
       restructuring costs.

   (2) Extraordinary charge for redemption of subordinated debt:  1996 - $1,176, net of tax effect of $817.

   (3) Restated to give effect to a stock split in the form of a 50% stock dividend in 1996.

   </TABLE>
                                      1
   <PAGE>

   Bio-Rad Laboratories, Inc.
   Consolidated Balance Sheets
   (In thousands)
   <TABLE>
   <CAPTION>
   ________________________________________________________________________________________
                                                                    December 31,
   Assets                                                       1998             1997
   <S>                                                       <C>              <C>
   Current Assets:
     Cash and cash equivalents                               $ 10,081         $ 10,843
     Accounts receivable, less allowance of $3,629 in 1998
        and $3,374 in 1997                                    106,010           96,965

     Inventories:
       Raw materials                                           26,038           27,257
       Work in process                                         21,614           21,242
       Finished goods                                          44,759           42,929
         Total inventories                                     92,411           91,428

     Deferred tax assets                                       18,340           15,524
     Prepaid expenses and other current assets                  8,547           12,658
         Total current assets                                 235,389          227,418

   Property, Plant and Equipment:
     Land and improvements                                      8,057            8,057
     Buildings and leasehold improvements                      56,280           55,477
     Equipment                                                133,838          115,097
         Total property, plant and equipment                  198,175          178,631
     Accumulated depreciation                                (116,045)         (99,953)
         Net property, plant and equipment                     82,130           78,678

   Marketable Securities                                        6,174           18,092
   Goodwill                                                    18,616           20,959
   Other Assets                                                24,990            6,729

   Total Assets                                              $367,299         $351,876

   ________________________________________________________________________________________
   </TABLE>

   The accompanying notes are an integral part of these statements.

                                      2
   <PAGE>

   Bio-Rad Laboratories, Inc.
   Consolidated Balance Sheets
   (In thousands, except share data)
   <TABLE>
   <CAPTION>
   __________________________________________________________________________________________
                                                                          December 31,
   Liabilities and Stockholders' Equity                                1998          1997
   <S>                                                               <C>           <C>
   Current Liabilities:
     Notes payable                                                   $  8,721      $  9,872
     Current maturities of long-term debt                                 672           930
     Accounts payable                                                  26,706        32,385
     Accrued payroll and employee benefits                             27,351        24,825
     Sales, income and other taxes payable                              6,396         5,055
     Other current liabilities                                         27,398        27,715
          Total current liabilities                                    97,244       100,782

   Long-Term Debt, net of current maturities                           42,339        38,952
   Deferred Tax Liabilities                                            13,382        15,465
          Total liabilities                                           152,965       155,199

   Commitments and Contingent Liabilities

   Stockholders' Equity:
     Preferred stock, $1.00 par value, 2,300,000 shares authorized;
       none outstanding                                                     -             -
     Class A common stock, $1.00 par value, 15,000,000 shares
       authorized; outstanding 1998 - 9,973,679;
       1997 - 9,824,509                                                 9,974         9,825
     Class B common stock, $1.00 par value, 6,000,000 shares
       authorized; outstanding 1998 - 2,452,899;
       1997 - 2,596,069                                                 2,453         2,596
     Additional paid-in capital                                        18,523        18,426
     Class A treasury stock, 306,368 shares in 1998 and                (7,047)       (5,206)
       193,539 shares in 1997 at cost
     Class B treasury stock, 30,000 shares in 1997 at cost                  -          (800)
     Retained earnings                                                189,838       167,182
     Accumulated other comprehensive income:
       Currency translation                                                92        (1,149)
       Net unrealized holding gain on marketable securities               501         5,803

          Total stockholders' equity                                  214,334       196,677

   Total Liabilities and Stockholders' Equity                        $367,299      $351,876
   __________________________________________________________________________________________
   </TABLE>

   The accompanying notes are an integral part of these statements.

                                      3
   <PAGE>

   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Income
   (In thousands, except per share data)
   <TABLE>
   <CAPTION>
   ______________________________________________________________________________________________________________________
                                                                                     Year Ended December 31,
                                                                           1998               1997                1996
   <S>                                                                   <C>                <C>                 <C>
   Net sales                                                             $441,942           $426,914            $418,789
     Cost of goods sold                                                   202,438            189,331             182,046

   Gross profit                                                           239,504            237,583             236,743

     Selling, general and administrative expense                          166,978            164,792             155,516
     Product research and development expense                              41,381             46,138              39,580
     Restructuring costs                                                        -                  -               2,700

   Income from operations                                                  31,145             26,653              38,947

   Other income (expense):
     Interest expense                                                      (3,731)            (1,216)             (3,027)
     Investment income, net                                                 8,790              1,601               2,385
     Other, net                                                            (1,976)            (4,310)             (1,832)

   Income before taxes and extraordinary charge                            34,228             22,728              36,473
     Provision for income taxes                                             9,926              6,364               9,118
   Income before extraordinary charge                                      24,302             16,364              27,355
     Extraordinary charge, net of tax effect of $817                            -                  -              (1,176)

   Net income                                                            $ 24,302           $ 16,364            $ 26,179

   Basic earnings per share:
     Income before extraordinary charge                                     $1.98              $1.33               $2.23
       Extraordinary charge                                                     -                  -                (.10)

     Net income                                                             $1.98              $1.33               $2.13

     Weighted average common shares                                        12,264             12,260              12,273

   Diluted earnings per share:
     Income before extraordinary charge                                     $1.97              $1.32               $2.19
       Extraordinary charge                                                     -                  -                (.09)

     Net income                                                             $1.97              $1.32               $2.10

     Weighted average common shares                                        12,358             12,394              12,472
   _______________________________________________________________________________________________________________________
   </TABLE>

   The accompanying notes are an integral part of these statements.

                                      4
   <PAGE>

   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Cash Flows
   (In thousands)
   <TABLE>
   <CAPTION>
   ________________________________________________________________________________________________________
                                                                           Year Ended December 31,
                                                                       1998         1997        1996
   <S>                                                               <C>         <C>         <C>
   Cash flows from operating activities:
        Cash received from customers                                 $436,029    $414,694    $409,144
        Cash paid to suppliers and employees                         (395,265)   (381,489)   (354,641)
        Interest paid                                                  (3,833)     (1,155)     (3,710)
        Income tax payments                                            (9,370)    (10,950)    (16,923)
        Miscellaneous receipts (payments)                                (226)          9        (717)

        Net cash provided by operating activities                      27,335      21,109      33,153

   Cash flows from investing activities:
        Capital expenditures, net                                     (21,176)    (23,571)    (15,235)
        Payments for acquisitions                                           -     (31,238)     (1,290)
        Purchases of marketable securities and investments            (19,086)     (8,352)     (2,710)
        Sales of marketable securities and investments                 16,367       3,419       2,968
        Foreign currency hedges, net                                   (1,360)      3,817       1,423

        Net cash used in investing activities                         (25,255)    (55,925)    (14,844)

   Cash flows from financing activities:
        Net borrowings under line-of-credit arrangements               (1,365)      4,665      (8,940)
        Long-term borrowings                                          133,710      87,275       5,024
        Payments on long-term debt                                   (130,666)    (55,329)    (20,841)
        Proceeds from issuance of common stock                            103       1,459       1,262
        Purchase of treasury stock                                     (4,665)     (5,302)     (1,887)
        Reissuance of treasury stock                                    1,978         750         215

        Net cash provided by (used in) financing activities              (905)     33,518     (25,167)

   Effect of exchange rate changes on cash                             (1,937)      2,751       1,474

   Net increase (decrease) in cash and cash equivalents                  (762)      1,453      (5,384)

   Cash and cash equivalents at beginning of year                      10,843       9,390      14,774

   Cash and cash equivalents at end of year                          $ 10,081    $ 10,843    $  9,390

   ________________________________________________________________________________________________________
   </TABLE>

   The accompanying notes are an integral part of these statements.

                                      5
   <PAGE>

   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Changes in Stockholders' Equity
   (In thousands)
   <TABLE>
   <CAPTION>
   ______________________________________________________________________
                                              Year Ended December 31,
                                           1998        1997       1996
   <S>                                    <C>        <C>        <C>
   Common Stock, $1.00 par value:
     Balance at beginning of year         $12,421    $ 12,321   $ 12,239
     Issuance of common stock                   6         100         82
     Balance at end of year                12,427      12,421     12,321

   Additional Paid-In Capital:
     Balance at beginning of year          18,426      17,067     15,887
     Issuance of common stock                  97       1,359      1,188
     Cash paid in lieu of fractional
       shares on 3-for-2 stock split            -           -         (8)
     Balance at end of year                18,523      18,426      17,067

   Treasury Stock:
     Balance at beginning of year          (6,006)     (1,639)         -
     Purchase of treasury stock            (4,665)     (5,302)    (1,887)
     Reissuance of treasury stock           3,624         935        248
     Balance at end of year                (7,047)     (6,006)    (1,639)

   Retained Earnings:
     Balance at beginning of year         167,182     151,003    124,857
     Net income                            24,302      16,364     26,179
     Reissuance of treasury stock at
       less than cost                      (1,646)       (185)       (33)
     Balance at end of year               189,838     167,182    151,003

   Accumulated Other Comprehensive Income:
     Balance at beginning of year           4,654       4,756      4,076
     Currency translation adjustments       1,241      (4,719)        43
     Net unrealized holding gains             819       5,746      1,767
     Reclassification adjustment for
       gains included in net income        (6,121)     (1,129)    (1,130)
     Balance at end of year                   593       4,654      4,756
                                         ________    ________   ________

   Total Stockholders' Equity            $214,334    $196,677   $183,508


   Comprehensive Income:
     Net income                          $ 24,302    $ 16,364   $ 26,179
     Currency translation adjustments       1,241      (4,719)        43
     Net unrealized holding gains             819       5,746      1,767
     Reclassification adjustments for
       gains included in net income        (6,121)     (1,129)    (1,130)

   Total Comprehensive Income            $ 20,241    $ 16,262   $ 26,859
   _________________________________________________________________________
   </TABLE>

   The accompanying notes are an integral part of these statements.

                                      6
   <PAGE>

   Bio-Rad Laboratories, Inc.

   Notes to Consolidated Financial Statements
   _________________________________________________________________

   1.  Significant Accounting Policies

   Basis of Presentation

   The consolidated financial statements include the accounts of Bio-Rad
   Laboratories, Inc. and all subsidiaries ("Bio-Rad" or the "Company")
   after elimination of intercompany balances and transactions.  The
   preparation of financial statements in conformity with generally
   accepted accounting principles requires management to make estimates
   and assumptions that affect the amounts reported in the financial
   statements and accompanying notes.  Changes in such estimates may
   affect amounts reported in the future.  Certain amounts in the
   financial statements of prior years have been reclassified to be
   consistent with the 1998 presentation.

   Cash and Cash Equivalents

   Cash and cash equivalents consist of cash and highly liquid in-
   vestments with original maturities of three months or less which are
   readily convertible into cash.  Cash equivalents are stated at cost,
   which approximates market value.

   Concentration of Credit Risk

   Financial instruments that potentially subject the Company to
   concentration of credit risk consist primarily of trade accounts
   receivable.  The Company performs credit evaluation procedures and
   with the exception of the Pacific Rim, generally does not require
   collateral.  As a result of increased risk in certain Pacific Rim
   countries, many Bio-Rad sales are subject to collateral letters of
   credit.  Credit risk is limited due to the large number of customers
   and their dispersion across many geographic areas.  However, a
   significant amount of trade receivables are with national healthcare
   systems in countries within the European Economic Community.  The
   Company does not currently anticipate a credit risk associated with
   these receivables.

   Inventory Valuation

   Inventories are valued at the lower of average cost or market and
   include material, labor and overhead costs.

   Property, Plant and Equipment

   Property, plant and equipment are carried at historical cost.
   Depreciation is computed on a straight-line basis over the estimated
   useful lives of the assets ranging from two to thirty years.
   Leasehold improvements are amortized over the lives of the respective
   leases or the lives of the improvements, whichever is shorter.


                                      7
   <PAGE>

   Marketable Securities

   The Company's marketable securities are classified as available-for-
   sale and are recorded at current market value.  Unrealized holding
   gains and losses are included as a separate component of stockholders'
   equity.  Realized gains and losses are included in investment income.
   For the purpose of determining realized gains and losses, the cost of
   securities sold is based upon specific identification.

   Goodwill

   Goodwill, representing the excess of the cost over the net tangible
   and identifiable intangible assets of acquired businesses, is stated
   at cost and is amortized on a straight-line basis over the estimated
   future periods to be benefited, typically ten years.  The Company
   reviews the recoverability of goodwill annually.

   Revenue Recognition and Warranty

   Bio-Rad recognizes revenues when products are shipped or services are
   rendered and all significant obligations of the Company have been met.
   Where appropriate, the Company also establishes a concurrent reserve
   for returns and allowances.

   The Company warrants certain equipment against defects in design,
   materials and workmanship, generally for one year.  Upon shipment of
   equipment sold at a price which includes a warranty, the Company
   establishes, as part of cost of goods sold, a provision for the
   expected costs of such warranty.

   Foreign Currency Translation

   Balance sheet accounts of international subsidiaries are translated at
   the current exchange rate as of the end of the accounting period.
   Income statement items are translated at average exchange rates.  The
   resulting translation adjustment is recorded as a separate component
   of stockholders' equity.

   Forward Exchange Contracts

   The Company does not use derivative financial instruments for
   speculative or trading purposes.  As part of distributing its
   products, the Company regularly enters into intercompany transactions.
   The Company enters into forward foreign exchange contracts to hedge
   against future movements in foreign exchange rates that affect foreign
   currency denominated intercompany receivables and payables.  These
   contracts generally have maturity dates of 60 days or less, relate
   primarily to currencies of industrial countries and are marked to
   market at each balance sheet date.  The resulting gains or losses are
   included in other income and expense offsetting exchange losses or
   gains on the related receivables and payables.  Unrealized gains and
   losses are not deferred.  Exchange gains and losses on these contracts
   are net of premiums and discounts resulting from interest rate
   differentials between the U.S. and the countries of the currencies
   being traded.  The cash flows related to these contracts are

                                      8
   <PAGE>

   classified as cash flows from investing activities in the statement of
   cash flows.

   Stock Compensation Plans

   Stock-based compensation is recognized using the intrinsic value
   method.  For disclosure purposes, pro forma net income and earnings
   per share are provided as if the fair value method had been applied.

   Earnings Per Share

   Basic earnings per share are calculated on the basis of the weighted
   average number of common shares outstanding for each period.  Diluted
   earnings per share are calculated assuming the exercise of certain
   stock options.  Treasury stock is not considered outstanding for
   purposes of calculating weighted average shares.

   Fair Value of Financial Instruments

   For certain of the Company's financial instruments, including cash and
   cash equivalents, accounts receivable, notes payable, accounts
   payable, long-term debt and forward exchange contracts, the carrying
   amounts approximate fair value.  The fair values of other instruments
   are disclosed in relevant notes to the financial statements.

   2.  Acquisitions

   In December 1997, the Company acquired, for cash, the assets used by
   Chiron Diagnostics Corporation in the business of manufacturing,
   marketing and selling diagnostic controls (exclusive of blood gas
   controls).  The business has been combined with the Clinical
   Diagnostics controls business based in southern California.

   In October 1997, the Company acquired, for cash, substantially all of
   the assets of Protein Databases, Inc.  The assets purchased have been
   utilized by the Life Science segment in its imaging products.

   In September 1997, the Company acquired, for cash, certain assets
   related to the design and manufacture of the optical production
   profiler from Pacific Scientific Company.  This expanded the
   semiconductor products offered by the Analytical Instruments segment.

   <TABLE>
   In conjunction with these acquisitions, liabilities were assumed and
   incurred as follows (in thousands):
   <CAPTION>
             <S>                                     <C>
             Assigned value of assets acquired       $12,173
             Goodwill                                 20,959
             Cash paid                               (31,238)
             Liabilities assumed and incurred        $ 1,894
   </TABLE>

                                      9
   <PAGE>

   3. Marketable Securities

   The Company's portfolio is comprised principally of equity securities
   with an aggregate market value of $6,174,000 and $18,092,000 and cost
   of $5,469,000 and $12,289,000 at December 31, 1998 and 1997,
   respectively.  At December 31, 1998, gross unrealized holding gains
   and losses were $1,044,000 and $339,000, respectively.  At December
   31, 1997, gross unrealized holding gains and losses were $6,039,000
   and $236,000, respectively.

   <TABLE>
   Information regarding the proceeds and gross realized gains and losses
   from sales of securities is as follows (in thousands):
   <CAPTION>

                                      Year Ended December 31,
                                    1998        1997        1996
   <S>                            <C>         <C>         <C>
   Proceeds                       $ 16,367    $  3,419    $ 2,968

   Gross realized gains           $  9,168    $  1,211    $ 1,130
   Gross realized losses              (548)        (82)         -
   Net realized gain              $  8,620    $  1,129    $ 1,130
   </TABLE>

   4.  Investment in Affiliates

   Beginning in December 1997, Bio-Rad began investing in Instrumentation
   Laboratory, S.p.A. (IL), an Italian based clinical diagnostics company
   with fiscal 1997 revenues in excess of $200 million.  At December 31,
   1998, Bio-Rad held approximately 26% of the outstanding stock of IL.
   Grupo CH-Werfen, S.A., a privately held company based in Spain,
   controls over 50% of the outstanding stock of IL.  Approximately 29%
   of the outstanding stock of IL is available in the U.S. evidenced by
   American Depository Shares (Nasdaq:ILABY).  The most recently
   published financial statements for IL are as of February 28, 1998.

   Prior to September 1998, Bio-Rad classified the investment as
   Marketable Securities.  Given the limited availability of financial
   information and the low volume of shares traded in recent months, Bio-
   Rad management does not believe there is a sufficient liquid market
   for IL stock.  Accordingly, the investment was reclassified to Other
   Assets.  Additionally, since Bio-Rad does not have the ability to
   significantly influence the operating and financial policies of IL,
   the investment has been recorded at its cost of $18,159,000.

   An unrealized holding gain of $652,000 was included in comprehensive
   income in 1997.  This amount was reversed in 1998 when the investment
   in IL was reclassified to Other Assets.

   5.  Notes Payable and Long-Term Debt

   Notes payable include local credit lines maintained by the Company's
   subsidiaries aggregating approximately $33,311,000, of which
   $24,592,000 was unused at December 31, 1998.  The weighted average
   interest rate on these lines was 5.14% and 5.78% at December 31, 1998
   and 1997, respectively.  The parent company guarantees most of these
   credit lines.

                                     10
   <PAGE>

   <TABLE>
   The principal components of long-term debt are as follows (in
   thousands):
   <CAPTION>
                                               December 31,
                                           1998            1997
   <S>                                   <C>             <C>
   Revolving credit agreement            $42,000         $38,000
   Capitalized leases                        606           1,046
   Other                                     405             836
                                          43,011          39,882
   Less current maturities                   672             930
   Long-Term Debt                        $42,339         $38,952
   </TABLE>

   The Company entered into a $100 million revolving credit agreement on
   May 15, 1998, replacing the $60 million credit agreement previously in
   place.  The new agreement provides for borrowings on an unsecured
   basis through May 2003.  Interest is based upon Eurodollar or
   corporate base (prime) rates.  The applicable interest rates at
   December 31, 1998 and 1997 were 5.96% and 6.49%, respectively.  A fee
   ranging from 0.15% to 0.30% annually is charged on the daily
   unborrowed portion of the commitment.

   The Company entered into interest rate swap agreements to reduce the
   impact of changing interest rates on its revolving credit agreement.
   At December 31, 1998, the Company had two interest rate swap
   agreements with commercial banks, having an aggregate notional amount
   of $25 million.  The agreements essentially fix the Company's interest
   rate exposure on $25 million worth of floating rate loans under its
   revolving credit agreement at 6.30%.  The agreements mature in
   December 2000, and June 2002.  The resulting applicable interest rate
   was 6.23% on the revolving credit agreement.  In terms of the interest
   rate swap, the Company is exposed to credit loss in the event of
   nonperformance by a counterparty, however the Company has not
   experienced such nonperformance to date and considers such a
   possibility remote.

   The Company redeemed all of its 10.9% Subordinated Notes in
   December 1996.  This redemption resulted in an extraordinary
   charge of $1,176,000, net of income tax benefits of $817,000.  The
   debt was extinguished with current operating funds and $5,000,000
   borrowed from the Company's revolving credit agreement.

   The revolving credit agreement (including amendments) requires the
   Company, among other things, to comply with certain financial
   ratio covenants.  The Company was in compliance with all financial
   ratio covenants as of December 31, 1998.  This agreement also
   contains certain other restrictions, including the limitation of
   cash dividends.  Approximately $11,486,000 of retained earnings
   were available for payment of cash dividends at December 31, 1998.

   Maturities of long-term debt at December 31, 1998, are as follows:
   1999 - $672,000; 2000 - $213,000; 2001 - $116,000; 2002 - $10,000;
   2003 - $42,000,000.

                                     11
   <PAGE>

   6.  Income Taxes

   <TABLE>
   The U.S. and international components of  income before taxes and
   extraordinary charge are as follows (in thousands):
   <CAPTION>
                                      Year Ended December 31,
                                    1998       1997        1996
   <S>                            <C>        <C>         <C>
   U.S.                           $ 24,173   $ 11,343    $ 23,766
   International                    10,055     11,385      12,707
   Income before taxes and
     extraordinary charge         $ 34,228   $ 22,728    $ 36,473
   </TABLE>

   <TABLE>
   The provision for income taxes consists of (in thousands):
   <CAPTION>
                                      Year Ended December 31,
                                    1998       1997        1996
   <S>                            <C>        <C>         <C>
   Current:
     U.S. Federal                 $  8,564   $  3,277    $  7,613
     International                   4,974      3,226       6,070
     U.S. State                        374        552       1,122
                                    13,912      7,055      14,805

   Deferred                         (3,986)      (691)     (5,687)

   Provision for income taxes     $  9,926   $  6,364    $  9,118
   </TABLE>

   <TABLE>
   The Company's income tax provision differs from the amount
   computed by applying the U.S. federal statutory rate to income
   before taxes as follows:
   <CAPTION>
                                       Year Ended December 31,
                                     1998        1997         1996
   <S>                              <C>        <C>         <C>
   U.S. statutory tax rate           35%        35%         35%
   State taxes, net of
     federal income tax benefit      (1)         1           1
   Foreign Sales Corporation
     tax benefit                     (5)        (6)         (4)
   Research and development
     tax credit                      (1)        (2)         (1)
   International taxes in excess
     of U.S. Foreign Tax Credit       -          1           4
   Loss carryforwards utilized       (1)        (6)         (4)
   Amortization of goodwill           -          2           -
   Other                              2          3           (6)
   Provision for income taxes        29%        28%         25%
   </TABLE>

                                     12
   <PAGE>

   <TABLE>
   Deferred income taxes reflect the net tax effect of temporary
   differences between the carrying amounts of assets and
   liabilities for financial reporting purposes and the amounts used
   for income tax purposes.  Significant components of deferred tax
   assets and liabilities are as follows (in thousands):
   <CAPTION>
                                                December 31,
                                            1998            1997
   <S>                                   <C>             <C>
   Deferred Tax Assets:
     Reserves for obsolete inventory,
       warranty and bad debts            $ 12,102        $ 10,418
     Eliminated intercompany profit         3,265           3,483
     Tax benefit of foreign loss
       carryforwards                        4,732           1,822
     Other                                  3,583           3,086
                                           23,682          18,809
     Valuation allowance                   (5,342)         (3,285)
     Deferred Tax Assets                 $ 18,340        $ 15,524

   Deferred Tax Liabilities:
     Deferred gain on condemnation       $  4,473        $  4,426
     Depreciation                           1,174           1,921
     Development cost of Hercules
       facility                             1,413           1,438
     Other                                  6,322           7,680
     Deferred Tax Liabilities            $ 13,382        $ 15,465
   </TABLE>

   The valuation allowance is needed to reduce the deferred tax
   assets to an amount that is more likely than not to be realized.
   The net change in the valuation allowance in 1998 was an increase
   of $2,057,000, primarily resulting from an increase in tax loss
   carryforwards.  The net change in 1997 was a decrease of
   $2,287,000, primarily resulting from unanticipated utilization of
   foreign loss carryforwards.

   At December 31, 1998, Bio-Rad's international subsidiaries had
   combined net operating loss carryforwards of $11,600,000.  A
   portion of these loss carryforwards will expire in the following
   years: 1999 - $1,440,000; 2000 - $762,000; 2001 - $371,000; 2002
   - $1,148,000; 2003 - $422,000; 2004 - $260,000; 2005 - $1,543,000
   and 2008 - $243,000.  The remainder of these loss carryforwards
   have no expiration date.  The utilization of these carryforwards
   is limited to the separate taxable income of each individual
   subsidiary.

   Bio-Rad does not provide for taxes which would be payable if the
   cumulative undistributed earnings of its international subsidiaries,
   approximately $24,923,000 at December 31, 1998, were remitted to the
   U.S. parent company.  Unless it becomes advantageous for tax or
   foreign exchange reasons to remit a subsidiary's earnings, such
   earnings are indefinitely reinvested in subsidiary operations.  The
   withholding tax and U.S. federal income taxes on these earnings, if
   remitted, would in large part be offset by tax credits.

                                     13
   <PAGE>

   7.  Stockholders' Equity

   Stock Classification

   The Company's outstanding stock consists of Class A Common Stock
   (Class A) and Class B Common Stock (Class B).   Each share of
   Class A and Class B participates equally in the earnings of Bio-
   Rad, and is identical in most respects except that (i) Class A
   has limited voting rights, each share of Class A being entitled
   to one-tenth of a vote on most matters and each share of Class B
   being entitled to one vote; (ii) Class A stockholders are
   entitled to elect 25% of the Board of Directors (rounded up to
   the nearest whole number) and Class B stockholders are entitled
   to elect the balance of the directors; (iii) cash dividends may
   be paid on Class A shares without paying a cash dividend on Class
   B shares, but no cash dividend may be paid on Class B shares
   unless at least an equal cash dividend is paid on Class A shares;
   and (iv) Class B shares are convertible at any time into Class A
   shares on a one-for-one basis at the option of the stockholder.

   Stock Option Plans

   Bio-Rad maintains incentive and non-qualified fixed stock option
   plans for officers and certain other key employees.  Under the
   Amended 1994 Stock Option Plan, the Company may grant options to
   its employees for up to 1,175,000 shares of common stock provided
   that no option shall be granted after March 1, 2004.  Under the
   plans, Class A and Class B options are granted at prices not less
   than fair market value on the date of grant, are exercisable on a
   cumulative basis at a rate not greater than 25% per annum
   commencing one year after the date of grant and expire five years
   after the date of grant.

   The Company has made no charge to income with respect to any
   stock options.  At the time options are exercised, the par value
   of the shares is credited to common stock and the excess is
   credited to additional paid-in capital.  The Company may receive
   income tax benefits from the exercise of non-qualified stock
   options and from certain dispositions of stock received by
   employees under qualified or incentive stock options.  The fair
   value of each option granted since January 1, 1995, was estimated
   on the date of the grant using the Black-Scholes option-pricing
   model with the following assumptions for grants in 1998, 1997 and
   1996, respectively:  no dividend yield for all periods; expected
   lives of 2.0 and 2.9 years in 1998 and 1.8 and 2.8 years in 1997
   and 1996; expected volatility of 35%, 33% and 33%; and risk-free
   interest rates ranging from 5.39% to 5.48%, 5.63% to 6.15% and
   4.85% to 5.27%.

                                     14
   <PAGE>

   <TABLE>
   Activity under the plans is summarized below (amounts reported in the Price columns
   represent the weighted average exercise price):
   <CAPTION>
                                                                 Year Ended December 31,
                                                1998                        1997                      1996
                                        Shares         Price        Shares         Price      Shares         Price
     <S>                                <C>            <C>          <C>           <C>         <C>           <C>
     Outstanding at beginning of year   517,018        $21.40       482,900       $16.34      427,457       $12.39
     Granted                            150,653         23.54       147,050        32.54      147,000        26.55
     Exercised                          (89,625)        10.09       (90,445)       11.88      (59,576)       11.12
     Forfeited                          (14,677)        25.07       (19,909)       25.38      (31,981)       20.21
     Expired                             (2,322)         9.46        (2,578)       12.04            -            -
     Outstanding at end of year         561,047         23.73       517,018        21.40      482,900        16.34

     Options exercisable at year-end    222,539                     172,689                   149,605

     Weighted average fair value of
       options granted during the year    $7.62                      $10.76                     $8.57
   </TABLE>

   <TABLE>
   The following table summarizes information about fixed stock options outstanding at December 31, 1998:
   <CAPTION>
                                   Options Outstanding                                  Options Exercisable

                             Number        Weighted Average                         Number
           Range of        Outstanding         Remaining       Weighted Average  Exercisable    Weighted Average
        Exercise Prices    at 12/31/98     Contractual Life     Exercise Price   at 12/31/98     Exercise Price
        <S>                  <C>              <C>                  <C>             <C>              <C>
        $ 7.37 - $18.21      150,276          0.7 years            $14.11          123,223          $13.23
        $19.80 - $23.94      147,106          3.9                   23.10            6,976           19.89
        $25.92 - $31.63      161,971          2.4                   27.53           66,952           27.14
        $32.63 - $35.89      101,694          3.1                   32.82           25,388           32.82
        $ 7.37 - $35.89      561,047          2.5                   23.73          222,539           19.86
   </TABLE>

                                     15
   <PAGE>

   Employee Stock Purchase Plan

   Under the Amended and Restated 1988 Employee Stock Purchase Plan
   (the Plan), the Company has authorized the sale of 645,000 shares
   of Class A to eligible employees.  The purchase price of the
   shares under the Plan is the lesser of 85% of the fair market
   value on the first day of each calendar quarter, or 85% of the
   fair market value on the last day of each calendar quarter.
   Employees may designate up to 10% of their compensation for the
   purchase of stock.  Under the Plan, the Company sold 51,446
   shares for $1,129,000; 43,785 shares for $982,000 and 30,888
   shares for $742,000 to employees in 1998, 1997 and 1996,
   respectively.  At December 31, 1998, 64,126 shares remained
   authorized under the Plan.  Management anticipates a stockholder
   resolution to extend the Plan.

   The fair value of the employees' purchase rights since January 1,
   1995, was estimated using the Black-Scholes model with the
   following assumptions for 1998, 1997 and 1996, respectively:  no
   dividend yield for all periods; an expected life of three months
   for all periods; expected volatility ranging from 28% to 38%, 19%
   to 30% and from 26% to 38%; and risk-free interest rates ranging
   from 4.27% to 5.23%, 5.02% to 5.41% and from 4.90% to 4.99%.  The
   weighted average fair value of those purchase rights granted in
   1998, 1997 and 1996 was $5.55, $5.50 and $6.81, respectively.

   Pro Forma Disclosures

   <TABLE>
   Had compensation cost for the Company's stock-based compensation plans
   been determined based upon the fair value at grant dates for awards
   under those plans consistent with the method of Statement of Financial
   Accounting Standards (SFAS) No. 123, "Accounting for Stock-Based
   Compensation", the Company's net income and earnings per share would
   have been reduced to the pro forma amounts indicated below (in
   thousands except per share data):
   <CAPTION>
                                            Year Ended December 31,
                                          1998       1997        1996
   <S>                                   <C>        <C>        <C>
   Net income             As reported    $24,302    $16,364    $26,179
                          Pro forma      $23,026    $15,173    $25,348

   Diluted earnings per   As reported      $1.97      $1.32      $2.10
     share                Pro forma        $1.86      $1.22      $2.03
   </TABLE>

   Under the requirements of SFAS No. 123, the above disclosures
   relate only to options granted after December 15, 1994, and do
   not include the impact of outstanding options that were made
   prior to the period for which SFAS No. 123 is effective.  Since
   employee stock options vest over several years, and additional
   grants are likely to be made in the future, during the phase-in
   period of SFAS No. 123 the disclosures are not likely to be
   representative of the effects on reported pro forma net income or
   earnings per share in future years.

                                     16
   <PAGE>

   8. Earnings Per Share

   In the fourth quarter of 1997, Bio-Rad adopted SFAS No. 128,
   "Earnings per Share".  Basic earnings per share as required by
   SFAS No. 128 are equal to earnings per share as historically
   reported by Bio-Rad.  No historical restatement was necessary.

   Weighted average shares used for diluted earnings per share
   include the dilutive effect of outstanding stock options of
   94,000, 134,000 and 199,000 shares, for the years ended December
   31, 1998, 1997 and 1996, respectively.

   Options to purchase 229,000 and 133,000 shares of common stock
   were outstanding during 1998 and 1997, respectively, but were
   excluded from the computation of diluted earnings per share
   because the exercise price of the options was greater than the
   average market price of the common shares.  The options were
   still outstanding at the end of 1998.  No options were excluded
   in 1996.

   9.   Restructuring Costs

   In the fourth quarter of 1996, the Clinical Diagnostics segment
   provided a $2,700,000 restructuring charge and a $2,100,000
   charge to cost of goods sold related to product line
   restructuring in the immunoassay market and disposition of the
   related production and research facility in northern California.
   The restructuring charge consisted primarily of lease-related
   costs and write-offs of production and research equipment
   dedicated to the Company's closed system immunoassay product
   line.  The charge to cost of goods sold reflected the adjustment
   to inventory necessary to reduce the carrying value of inventory
   to its net realizable value.  Cash outlays were primarily for
   lease-related costs and commenced in the first quarter of 1997.
   Future lease payments have been reserved through 2000.  The
   Company is reviewing the use of this property and the reserve may
   be offset in the future should the Company sublease or utilize
   the property for alternative purposes.

   10.  Other Income and Expense

   <TABLE>
   Other, net includes the following income and (expense) components
   (in thousands):
   <CAPTION>
                                         Year Ended December 31,
                                      1998          1997         1996
   <S>                              <C>         <C>        <C>
   Amortization of goodwill         $(2,068)    $(1,612)   $  (132)
   Exchange gains (losses)               22        (711)      (641)
   Other non-operating litigation
     costs, net                         117      (1,606)      (971)
   Miscellaneous other items            (47)       (381)       (88)
   Other, net                       $(1,976)    $(4,310)   $(1,832)
   </TABLE>

                                     17
   <PAGE>

   Exchange gains (losses) include premiums and discounts on forward
   foreign exchange contracts.

   11.  Supplemental Cash Flow Information

   <TABLE>
   The reconciliation of net income to net cash provided by operating
   activities is as follows (in thousands):
   <CAPTION>
                                                      Year Ended December 31,
                                                     1998      1997      1996
   <S>                                             <C>       <C>       <C>
   Net income                                      $24,302   $16,364   $26,179
   Adjustments to reconcile net income to
    net cash provided by operating activities:
     Depreciation and amortization                  20,975    19,470    17,870
     Foreign currency hedge transactions, net        1,360    (4,001)   (1,275)
     Gains on dispositions of marketable securities (8,620)   (1,129)   (1,130)
     Increase in accounts receivable, net           (5,739)   (6,176)   (6,670)
     (Increase) decrease in inventories               (166)  (14,831)    5,339
     (Increase) decrease in other current assets     4,629    (6,369)      435
     Increase (decrease) in accounts payable and
      other current liabilities                     (4,808)   18,775     1,411
     Increase (decrease) in income taxes payable     1,040     1,122    (2,926)
     Decrease in deferred taxes                     (5,292)   (1,276)   (4,879)
     Other                                            (346)     (840)   (1,201)
   Net cash provided by operating activities       $27,335   $21,109   $33,153
   </TABLE>

   12.  Commitments and Contingent Liabilities

   Rents and Leases

   Net rental expense under operating leases was $12,622,000 in
   1998, $11,339,000 in 1997 and $11,505,000 in 1996.  Leases are
   principally for facilities and automobiles.

   Annual future minimum lease payments at December 31, 1998, under
   operating leases are as follows:  1999 - $9,076,000; 2000 -
   $6,050,000; 2001 - $4,524,000; 2002 - $4,184,000; 2003 -
   $3,599,000; subsequent to 2003 - $12,121,000.

   Deferred Profit Sharing Retirement Plan

   The Company has a profit sharing plan covering substantially all
   U.S. employees.  Contributions are made at the discretion of the
   Board of Directors.  Bio-Rad has no liability other than for the
   current year's contribution.  Contributions charged to income
   were $3,566,000, $3,285,000 and $3,165,000 in 1998, 1997 and
   1996, respectively.

                                     18
   <PAGE>

   Foreign Exchange Contracts

   The Company enters into forward foreign exchange contracts as a
   hedge against foreign currency denominated intercompany receiv-
   ables and payables.  At December 31, 1998, the Company had
   contracts maturing in January 1999 to sell foreign currency with
   a market value of $48,053,000 and to purchase foreign currency
   with a market value of $1,811,000.  At December 31, 1997, the
   Company had contracts maturing in January 1998 to sell foreign
   currency with a market value of $37,651,000 and to purchase
   foreign currency with a market value of $559,000.

   13. Legal Proceedings

   In the third quarter of 1996, Bio-Rad and Fuji Photo Film Co.,
   Ltd. reached a settlement in the action filed in Civil Department
   No. 29 of the Tokyo District Court in July 1994 alleging in-
   fringement of a Japanese patent which covers an autoradiographic
   process.  The settlement amounts were provided for in 1995 and
   1994.

   The Company is a party to various other claims, legal actions and
   complaints arising in the ordinary course of business.  One such
   action relates to the U.S. Environmental Protection Agency which
   has informed the Company that it may be a potentially responsible
   party under the Comprehensive Environmental Response, Compensa-
   tion and Liability Act, as amended, at one site in Colorado.  In
   the opinion of management, the outcome of this and other claims,
   legal actions and complaints would have no material adverse
   effect on the future results of operations or the financial
   position of the Company.

   14.  Segment Information

   The Company adopted SFAS No. 131, "Disclosures about Segments of
   an Enterprise and Related Information" in 1998 which changes the
   way the Company reports information about its operating segments.
   The information for 1997 and 1996 has been restated in order to
   conform to the 1998 presentation.

   Bio-Rad is a multinational manufacturer and worldwide distributor
   of life science research products, clinical diagnostics and
   analytical instruments.  Bio-Rad has three reportable segments:
   Life Science, Clinical Diagnostics and Analytical Instruments.
   These reportable segments are strategic business lines that offer
   different products and services and require different marketing
   strategies.

   The Life Science segment develops, manufactures, sells and
   services liquid chromatography, electrophoresis, gene
   amplification and transformation, imaging and image analysis, DNA
   sequencing and sample preparation products.  These products are
   sold to university and medical school laboratories,

                                     19
   <PAGE>

   pharmaceutical and biotechnology companies, and government and
   industrial research facilities.

   The Clinical Diagnostics segment develops, manufactures, sells
   and services automated test systems, informatics systems, test
   kits and specialized quality controls for the healthcare market.
   These products are sold to reference laboratories, hospital
   laboratories, state newborn screening facilities, physicians
   office laboratories, and insurance and forensic testing
   laboratories.

   The Analytical Instruments segment develops, manufactures, sells
   and services FT-IR spectroscopy systems, semiconductor test and
   manufacturing instruments, spectral reference publications and
   software.  These products are sold to industrial companies,
   government institutions, academia and forensic analysis
   laboratories.

   The accounting policies of the segments are the same as those
   described in Significant Accounting Policies (see Note 1).
   Segment profit or loss used for corporate management purposes
   includes an allocation of corporate expense based upon sales and
   an allocation of interest expense based upon accounts receivable
   and inventories.  In addition, certain items that are classified
   as non-operating expenses and reported as other income and
   expense on a consolidated basis are included in segment profit or
   loss.  Segments are expected to manage only assets completely
   under their control.  Accordingly, segment assets include
   primarily accounts receivable, inventories and gross machinery
   and equipment.

   <TABLE>
   Information regarding industry segments at December 31, 1998,
   1997 and 1996 and for the years then ended is as follows (in
   thousands):
   <CAPTION>
                                        Life     Clinical    Analytical
                                       Science  Diagnostics Instruments
   <S>                          <C>   <C>         <C>         <C>
   Segment net sales            1998  $209,655    $170,002    $ 66,100
                                1997   205,704     150,095      75,800
                                1996   199,461     148,938      74,034


   Allocated interest expense   1998  $  1,501    $  1,464    $    571
                                1997       550         428         212
                                1996     1,344       1,237         541

   Depreciation and
     amortization               1998  $  7,328    $ 11,242    $  1,652
                                1997     7,258       7,553       3,768
                                1996     7,063       7,724       1,645


   Segment profit (loss)        1998  $ 12,649    $ 18,160    $ (2,166)
                                1997     6,816      19,257      (1,003)
                                1996    15,716      15,805       4,327


                                     20
   <PAGE>

   Segment assets               1998   $124,219    $129,089   $ 38,607
                                1997    116,289     111,453     44,964
                                1996    108,706      96,653     41,038

   Capital expenditures         1998   $  6,487    $ 15,213   $  1,912
                                1997      7,461      14,432      1,991
                                1996      7,103       7,514      2,133
   </TABLE>

   Capital expenditures include capitalized leases of $311,000,
   $331,000 and $872,000 in 1998, 1997 and 1996, respectively.

   <TABLE>
   Inter-segment sales are primarily between Life Science and
   Clinical Diagnostics and are priced to give Life Science a market
   representative gross margin.  The difference between total
   segment allocated interest expense, depreciation and
   amortization, and capital expenditures and the corresponding
   consolidated amounts is attributable to the Company's corporate
   headquarters.  The following reconciles total segment profit
   (loss) to consolidated income before taxes and extraordinary
   charge (in thousands):
   <CAPTION>
                                           Year Ended December 31,
                                          1998       1997       1996
   <S>                                  <C>        <C>        <C>
   Total segment profit (loss)          $28,643    $25,070    $35,848

   Gross profit on inter-segment sales   (1,925)    (2,338)    (1,791)
   Net corporate operating, interest
     and other expense not allocated
     to segments                         (1,280)    (1,605)        31
   Investment income, net                 8,790      1,601      2,385

   Consolidated income before taxes
     and extraordinary charge           $34,228    $22,728    $36,473
   </TABLE>

   <TABLE>
   The following reconciles total segment assets to consolidated total
   assets (in thousands):
   <CAPTION>
                                                December 31,
                                         1998       1997       1996
   <S>                                 <C>        <C>        <C>
   Total segment assets                $291,915   $272,706   $246,397
   Cash and other current assets         36,968     39,025     31,002
   Net property, plant and
     equipment excluding segment
     specific gross machinery and
     equipment                          (11,364)    (5,635)    (7,002)
   Other long-term assets                49,780     45,780     14,528

   Total assets                        $367,299   $351,876   $284,925
   </TABLE>

                                     21
   <PAGE>

   <TABLE>
   The following presents sales to external customers by geographic area
   based primarily on the location of the use of the product or service
   (in thousands):
   <CAPTION>
                                           Year Ended December 31,
                                         1998       1997       1996
   <S>                                 <C>        <C>        <C>
   Europe                              $141,004   $132,551   $141,142
   Pacific Rim                           88,917     98,070     94,794
   United States                        195,309    184,533    171,445
   Other (primarily Canada
     and Latin America)                  16,712     11,760     11,408

   Total net sales                     $441,942   $426,914   $418,789
   </TABLE>

   <TABLE>
   The following presents long-lived assets by geographic area based upon
   the location of the asset (in thousands):
   <CAPTION>
                                                  December 31,
                                          1998       1997       1996
   <S>                                 <C>        <C>        <C>
   Europe                              $  7,860   $  7,004   $  8,060
   Pacific Rim                            4,933      3,885      4,295
   United States                        118,628    112,967     73,352
   Other (primarily Canada
     and Latin America)                     489        602        683

   Total long-lived assets             $131,910   $124,458   $ 86,390
   </TABLE>

   15.  Quarterly Financial Data - (unaudited)

   <TABLE>
   Summarized quarterly financial data for 1998 and 1997 are as follows (in
   thousands, except per share data):
   <CAPTION>
                                     First      Second       Third    Fourth
                                    Quarter     Quarter     Quarter   Quarter
   <S>                             <C>         <C>         <C>       <C>
      1998

   Net sales                       $116,174    $107,898    $ 98,982  $118,888
   Gross profit                      64,076      58,857      53,577    62,994
   Net income                         8,776       7,151       1,938     6,437
   Basic earnings per share           $0.72       $0.58       $0.16     $0.52
   Diluted earnings per share         $0.71       $0.58       $0.16     $0.52

      1997

   Net sales                       $105,854    $105,752    $ 99,491  $115,817
   Gross profit                      62,141      58,721      54,835    61,886
   Net income                         7,494       4,899       2,614     1,357
   Basic earnings per share           $0.61       $0.40       $0.21     $0.11
   Diluted earnings per share         $0.60       $0.39       $0.21     $0.11
   </TABLE>

                                     22
   <PAGE>

   16.  Information Concerning Common Stock - (unaudited)

   <TABLE>
   The Company's Class A and Class B Common Stock are listed on the
   American Stock Exchange with the symbols BIO.A and BIO.B, respec-
   tively.  The following sets forth, for the periods indicated, the high
   and low sales prices for the Company's Class A and Class B Common
   Stock.
   <CAPTION>
                                Class A              Class B
                             High      Low        High      Low
   <S>                      <C>       <C>        <C>       <C>
        1998
   First Quarter            27        22-1/2     26-3/8    23-1/4
   Second Quarter           34-1/8    24-1/8     33-3/4    27
   Third Quarter            31-7/8    23-5/16    29-1/2    24-1/4
   Fourth Quarter           24-3/4    19-1/2     22-3/8    19-3/4

        1997
   First Quarter            33-1/2    25-1/2     32        26-3/4
   Second Quarter           27-15/16  23-3/8     27-1/2    23-1/4
   Third Quarter            30-3/4    26         30-1/8    26-1/4
   Fourth Quarter           30-1/4    23-7/16    29-3/8    29
   </TABLE>

   On February 22, 1999, the Company had 591 holders of record of Class
   A Common Stock and 281 holders of record of Class B Common Stock.
   Bio-Rad has never paid a cash dividend and has no present plans to
   pay cash dividends.






























                                     23
   <PAGE>

   REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

   To the Stockholders and Board of Directors of
   Bio-Rad Laboratories, Inc.:

   We have audited the accompanying consolidated balance sheets of
   Bio-Rad Laboratories, Inc. (a Delaware Corporation) and
   subsidiaries as of December 31, 1998 and 1997, and the related
   consolidated statements of income, cash flows and changes in
   stockholders' equity for each of the three years in the period
   ended December 31, 1998.  These financial statements are the
   responsibility of the Company's management.  Our responsibility
   is to express an opinion on these financial statements based on
   our audits.

   We conducted our audits in accordance with generally accepted
   auditing standards.  Those standards require that we plan and
   perform the audit to obtain reasonable assurance about whether
   the financial statements are free of material misstatement.  An
   audit includes examining, on a test basis, evidence supporting
   the amounts and disclosures in the financial statements.  An
   audit also includes assessing the accounting principles used and
   significant estimates made by management, as well as evaluating
   the overall financial statement presentation.  We believe that
   our audits provide a reasonable basis for our opinion.

   In our opinion, the consolidated financial statements referred to
   above present fairly, in all material respects, the financial
   position of Bio-Rad Laboratories, Inc. and subsidiaries as of
   December 31, 1998 and 1997, and the results of their operations
   and their cash flows for each of the three years in the period
   ended December 31, 1998 in conformity with generally accepted
   accounting principles.




                                          /s/  Arthur Andersen LLP

                                               ARTHUR ANDERSEN LLP

   San Francisco, California,
     February 3, 1999










                                     24
   <PAGE>

   Bio-Rad Laboratories, Inc.

   Management's Discussion and Analysis
   ________________________________________________________________

   MANAGEMENT'S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS AND
                             FINANCIAL CONDITION

   This discussion should be read in conjunction with the information
   contained in the Company's Consolidated Financial Statements and the
   accompanying notes which are an integral part of the statements.
   References are to the Notes to Consolidated Financial Statements.

   <TABLE>
   The following table shows operating income and expense items as a
   percentage of net sales:
   <CAPTION>
                                            Year Ended December 31,
                                             1998    1997    1996
   <S>                                       <C>     <C>     <C>
   Net sales                                 100.0   100.0   100.0
     Cost of goods sold                       45.8    44.3    43.5
   Gross profit                               54.2    55.7    56.5
     Selling, general and administrative      37.8    38.7    37.1
     Product research and development          9.4    10.8     9.5
     Restructuring costs                         -       -     0.6

   Income from operations                      7.0     6.2     9.3
                                             =====   =====   =====
   Income before extraordinary charge          5.5     3.8     6.5
                                             =====   =====   =====
   </TABLE>

   Corporate Results -- Sales, Margins and Expenses


   Bio-Rad's net sales (sales) in 1998 were $441.9 million, an increase
   of 3.5% over 1997 sales.  1998 marked the third consecutive year that
   a strengthening U.S. dollar caused Bio-Rad to report slower sales
   growth due to currency translation.  The 1998 impact was 2.5% or $10.5
   million, just slightly more than half of the impact in the prior year
   when sales were reduced by 4.6%.  When 1998 sales are compared to 1997
   at constant 1997 exchange rates, sales for the Company grew 6.0%.
   Eliminating the effect of a strengthened U.S. dollar, sales increased
   16% and 4% in Clinical Diagnostics and Life Science, respectively.
   The Analytical Instruments segment recorded 11% less in sales.  The
   growth in Clinical Diagnostics was largely attributed to the December
   1997 purchase of the controls business from Chiron Diagnostics
   Corporation.  Life Science experienced strong growth in the U.S.
   especially in the imaging and microscopy product lines.  Europe
   experienced slow growth, and Asia had a sales decline as research
   spending was limited by many governments in the area.  The Analytical
   Instruments segment experienced lower sales as the markets it served
   contracted almost worldwide.  This slowdown impacted the products sold

                                     25
   <PAGE>

   into the semiconductor test and manufacturing equipment market, which
   has been very successful for the past several years.

   Bio-Rad's sales in 1997 amounted to $426.9 million, an increase of
   1.9% over sales in 1996.  The effect of a strengthening U.S. dollar
   caused a reduction in sales growth of 4.6% or approximately $19.2
   million.  When 1997 sales are compared to 1996 at constant 1996
   exchange rates, sales for the Company grew 6.5%.  Sales increased in
   all segments of the Company's business.  Eliminating the effects of a
   strengthened U.S. dollar, sales increased 8% in Life Science, 6% in
   Analytical Instruments and 5% in Clinical Diagnostics.  Life Science
   sales growth was generated by its imaging product equipment and
   related software, gene transfer products, convenience electrophoresis
   and chromatography products.  Analytical Instruments saw continued
   growth in the products sold into the semiconductor test and
   manufacturing equipment market.

   Consolidated gross margins were 54.2% for 1998 compared to 55.7% in
   the prior year.  The decline in margins, as in 1997, reflects overall
   lower prices on international sales caused by a strengthening U.S.
   dollar and a majority of manufacturing costs being U.S. dollar
   denominated.  Clinical Diagnostics gross margins declined 3.1% of
   sales, in part, from the Chiron acquisition (see Note 2), where
   several large supply agreements existed.  Additionally, this business
   segment is seeing a continuing consolidation in its customer base.
   Company management believes that these larger, more formal agreements
   offer opportunities to offset pricing pressure through improved
   planning and resultant efficiencies.  Analytical Instruments margins
   were negatively impacted by an increasingly weak semiconductor market
   and the strengthening dollar.  Life Science margins declined from
   higher service and warranty costs, and were particularly impacted in
   Asia.

   Consolidated gross margins were 55.7% for 1997 compared to 56.5% for
   1996.  Gross margins overall were adversely affected by lower prices
   on international sales caused by the strengthening U.S. dollar and a
   majority of manufacturing costs being U.S. dollar denominated.
   Clinical Diagnostics gross margins declined by 0.6% of sales after
   adjustment for a $2.1 million 1996 write-down of inventory associated
   with a discontinued product line (see Note 9).  Analytical Instruments
   gross margins declined 0.8% of sales largely in the Company's
   spectroscopy equipment product line as a number of reengineering and
   organizational changes were made to the manufacturing operations of
   this product line.  Life Science margins declined 2.1% of sales.  In
   addition to the impact of lower overall prices mentioned above, this
   segment experienced increased warranty and service expenses, increased
   returns and allowances, and unfavorable manufacturing overhead
   absorption.

   Consolidated selling, general and administrative expense (SG&A)
   decreased to 37.8% of sales in 1998 when compared to 38.7% for 1997.
   Spending increased in absolute dollars only in the Clinical
   Diagnostics segment yet at a growth rate of approximately half the
   growth rate in sales.  Life Science and Analytical Instruments each
   had declines in absolute spending both from the currency effect on

                                     26
   <PAGE>

   foreign incurred SG&A and cost elimination programs begun in late
   1997.  SG&A headcount increased by approximately 7%; these increases
   took place in Asia and Latin America, developing markets for Bio-Rad,
   which have cost structures lower than those in the U.S. and Europe.

   SG&A increased to 38.7% of sales in 1997 from 37.1% in 1996.  Spending
   increased in absolute dollars in all segments, with each segment
   growing SG&A faster than sales.  While headcount grew approximately
   2.5% (excluding the acquisition in December 1997), salaries rose at an
   even faster rate particularly in the United States as the labor market
   became tighter and the cost of retaining and recruiting personnel
   increased.  Additionally, the Company increased its expenditures on
   information technology to add the necessary infrastructure for Bio-Rad
   to remain competitive in serving its worldwide customer base.

   Product research and development expense (R&D) decreased in 1998 by
   10% to $41.4 million.  Spending declined in the Life Science and
   Analytical Instruments segments and increased 3% in the Clinical
   Diagnostics segment.  Declines in Life Science and Analytical
   Instruments were due to the completion or termination of projects.
   Future spending levels are expected to be more conducive to improved
   profitability while retaining the potential to grow the business.

   R&D increased in 1997 by 16.6% to $46.1 million compared to $39.6
   million for the year 1996.  While spending increased in each segment,
   Clinical Diagnostics remained virtually unchanged as spending
   increased $0.1 million.  Life Science increased spending 24%.
   Analytical Instruments increased spending 28% as it prepared to meet
   new specifications for the next generation of test and measurement
   equipment and for new products that will complement the existing
   product line.

   In the fourth quarter of 1996, the Clinical Diagnostics segment made a
   provision of $2.7 million for lease-related occupancy costs and the
   write-down of certain dedicated fixed assets associated with its
   closed system immunoassay analyzer product line (see Note 9).

   Corporate Results -- Non-Operating Items

   Interest expense represents 0.8% of sales in 1998 compared to 0.3% in
   1997 and 0.7% in 1996.  The current year increase is attributable to
   an increase in the amount of interest bearing debt primarily resulting
   from the December 1997 acquisition.  Average borrowings for the years
   1998, 1997 and 1996 were $52.3 million, $14.7 million and $27.9
   million, respectively.  The decline in borrowings from 1996 to 1997
   reflects the repayment of $20.0 million of 10.9% Subordinated Notes in
   December 1996.  The funds were generated from operations and resulted
   in an extraordinary charge (see Note 5).

   Investment income in 1998, 1997 and 1996 includes gains on sales of
   marketable securities.  During 1998, Bio-Rad realized significant
   investment income, $8.6 million, as it sold some of its investment in
   marketable securities in order to increase its investment in
   Instrumentation Laboratory (see Note 4).  1996 included interest

                                     27
   <PAGE>

   income of $0.8 million from short-term investments as a result of
   accumulating cash prior to repaying the 10.9% Subordinated Notes.

   Net other income and expense for 1998 is comprised principally of
   amortization of goodwill (see Note 10).  Net other income and expense
   for 1997 was principally non-operating litigation costs and
   amortization of goodwill.  Net other income and expense for 1996 was
   principally non-operating litigation costs and exchange losses.  Bio-
   Rad's hedging program is limited to nonspeculative forward foreign
   exchange contracts (with major financial institutions) which hedge the
   exposure of intercompany receivables and payables.  The net exchange
   gain or loss results from the estimating inherent in projecting
   intercompany balances and from transaction charges.

   Bio-Rad's consolidated effective tax rate was 29%, 28% and 25% in
   1998, 1997 and 1996, respectively.   The higher effective tax rate for
   1998 is the result of changes in the source of taxable income and the
   diminishing availability of loss carryforwards.  The tax rate for all
   years reflects the utilization of loss carryforwards, foreign sales
   corporation benefits and foreign tax credits.  These benefits are not
   expected to continue indefinitely.  However, for 1999 and 2000, the
   rate should remain at existing levels, then begin to rise over time to
   normalized statutory rates.

   Financial Condition

   Historically, the Company's principal capital requirement was for
   working capital to fund its growth in operations.  Since 1994, the
   Company's efforts to improve profitability and emphasize working
   capital control have limited much of this requirement.

   At December 31, 1998, the Company had available $10.1 million in cash
   and cash equivalents, $24.6 million under its international lines of
   credit, $58.0 million under its principal revolving credit agreement
   (see Note 5) and marketable securities with a market value of  $6.2
   million, a majority of which could be readily converted into cash (see
   Note 3).

   Net cash provided by operations was $27.3 million, $21.1 million and
   $33.2 million in 1998, 1997 and 1996, respectively.  The 1998 increase
   in net cash provided by operations was caused by R&D spending declines
   year-over-year and slower SG&A growth than sales.

   Consolidated net accounts receivable increased 9.3% in 1998 when
   compared to 1997.  This increase is attributable to an increase in
   fourth quarter sales, the virtual elimination of factored receivables
   in Italy and Japan, and the late fourth quarter weakening of the U.S.
   dollar when compared to December 31, 1997 exchange rates.  Bio-Rad's
   management regularly reviews the allowance for uncollectible
   receivables and believes net receivables are fully realizable.

   For the year ended December 1998, consolidated inventories rose 1% to
   $92.4 million.  The Life Science and Analytical Instruments segments
   both had declining inventory levels from the prior year.  The Clinical
   Diagnostics segment added approximately $2.4 million to inventory as

                                     28
   <PAGE>

   it began to manufacture products destined to fill some recently
   completed supply contracts.  Inventory for the Clinical Diagnostics
   controls business, a growth area for the Company, is known for long
   lead times and large, infrequent batch production to meet customer
   requirements. The Company plans to increase its inventory levels in
   1999 in this business segment.  Management regularly reviews the
   impact of obsolescence on current inventory caused by the introduction
   of new products.  Management will continue its focus on inventory
   control in the coming year to moderate capital requirements.

   A valuation reserve is necessary for deferred tax assets (see Note 6)
   primarily because realization of tax attributable to foreign loss
   carryforwards is uncertain.

   Net capital expenditures in 1998 totaled $21.2 million compared to
   $23.6 million and $15.2 million in 1997 and 1996, respectively.
   Expenditures in 1998 again included additions to the Clinical
   Diagnostics segment's southern California manufacturing operations
   facilities to accommodate the consolidation of the acquired assets in
   the fourth quarter of 1997.  Expenditures in all years include
   clinical diagnostic equipment placed with customers to be used with
   the Company's diagnostic reagents.  Capital expenditures are expected
   to increase substantially in 1999 when compared to the past three
   years.  Consideration is being given to relocating the Life Science
   segment's northern California distribution and instrument
   manufacturing facility.  The final review and approval are scheduled
   to take place in the first quarter of 1999.  If approved, this will
   require a major investment, which could begin as early as the second
   quarter of 1999.  The capital commitment to this project could be
   approximately $25 million over two years.  Management regularly
   approves capital spending in the normal course of business.
   Additionally, the Company will continue its investment in information
   technology commenced in 1997 to provide the enterprise-wide
   infrastructure necessary for achieving greater competitiveness and
   further cost efficiencies.

   By historical standards, Bio-Rad's liquidity remained strong in 1998.
   Available funds and cash flow from operations are adequate to meet the
   Company's objectives for operations, research and development, and
   investment in its systems and equipment.

   In February 1998, the Board of Directors authorized the Company to
   repurchase up to an additional $10 million of common stock over an
   indefinite period of time.  This is the third such authorization since
   July 1996, bringing the total authorized to $18 million.  Through
   January 1999, the Company has repurchased 504,700 shares of Class A
   Common Stock and 30,000 shares of Class B Common Stock for a total of
   $12.8 million.  The repurchase is designed to improve shareholder
   value and to satisfy the Company's obligations under the employee
   stock purchase and stock option plans.

   The Company continues to regularly review acquisition opportunities;
   currently no material acquisitions have reached a stage beyond
   exploratory discussions.

                                     29
   <PAGE>

   Euro - A New European Currency

   On January 1, 1999, certain member countries of the European Union
   began to fix the conversion rates between their national currencies
   and a common currency, the "Euro."   Over the period January 1, 1999
   through January 1, 2002 participating countries will gradually
   transition from their national currencies to the Euro.

   This transition will have business implications including the need to
   adjust internal systems to accommodate the Euro and cross-border price
   transparency.  A group of Corporate and European managers have been
   assigned the task of preparing and accommodating the changes required
   to continue to do business in the European Union.  The Company does
   not presently expect that the efforts involved will have a material
   impact on operations, financial position or liquidity.  There will be
   increased competitive pressures, and marketing strategies will need to
   be continuously evaluated until the transition is complete.  As a
   result of competitive forces and emerging government regulations, the
   Company cannot guarantee that all problems will be foreseen and
   remediated, and that no material disruption will occur.

   Year 2000

   The Year 2000 issue is the result of computer programs being written
   using two rather than four digits to define the date.  Failure to
   recognize "00" as the year 2000 could result in a temporary inability
   to conduct normal business activities.

   Bio-Rad currently operates in a decentralized processing environment.
   The Company, with the assistance of outside consultants and
   contractors, is well underway with phased identification, remediation,
   replacement, validation and notification processes to minimize the
   potential disruption to business from information technology and non-
   information technology systems.  The project start-up, inventory and
   assessment phases are generally complete.  For each location
   remediations or scheduled replacements will be completed prior to the
   Year 2000 deadline.

   Bio-Rad's manufactured products have also been undergoing assessment
   for Year 2000 readiness.  Customers and investors can review the Year
   2000 readiness status of the Company's products on its web site,
   http://www.bio-rad.com.

   The Company has identified significant suppliers and is requesting
   information from them regarding the Year 2000 readiness of their
   products or services.  The Company has not yet received enough
   responses to ascertain that a material adverse impact can be avoided.
   It is not possible at this time to value the amount of business that
   might be lost as a result of Bio-Rad's business partners' failure to
   deliver products and services after December 31, 1999.  Additionally,
   global infrastructure comprised of banking, transportation,
   communication, power generation and ordinary and necessary
   governmental activities are critical to the Company's operations.
   Should any of these suppliers not be fully functional after 1999 the
   negative impact to the Company would be significant and material.

                                     30
   <PAGE>

   The expenditures required in 1998 and 1999 to replace and remediate
   Year 2000 non-compliant Bio-Rad information technology systems,
   including equipment, is estimated at $8 million and primarily deals
   with distribution system capabilities worldwide.  Approximately half
   of these costs have been incurred to date.  Hardware and software
   purchased and installed in connection with these projects will provide
   both Year 2000 readiness and significant additional functionality.
   Manufacturing systems have been remediated at a cost that is not
   material to Bio-Rad overall; these costs have been included in
   operating results in 1997 and 1998.  While some systems enhancements
   or modifications have been delayed to allow for the more significant
   Year 2000 remediation to be completed, weighing both cost and benefit,
   Bio-Rad management believes its response is prudent.

   The Company as of this date has not identified the "most likely worst
   case Year 2000 scenario."  That scenario will be largely dependent on
   the Company's significant worldwide suppliers and its assessment of
   preparedness of the global infrastructure, including multiple national
   governments.  During 1999 the Company will formulate and review
   contingency plans based on the aforementioned significant supplier
   responses and global infrastructure preparedness.

   Financial Risk Management

   Bio-Rad uses derivative financial instruments to reduce the Company's
   exposure to fluctuations in foreign exchange rates and interest rates.
   No derivative financial instruments are entered into for the purpose
   of speculating or trading.  Company policy limits all derivative
   positions exclusively to reducing risk by hedging an underlying
   economic exposure that can be effectively correlated to the Company's
   chosen hedging vehicle.  Changes in the value of the derivative are
   generally offset by reciprocal changes in Bio-Rad's underlying asset.

   Bio-Rad operates and conducts business in many foreign countries and
   is exposed to movements in foreign currency exchange rates.
   Additionally, Bio-Rad's consolidated net equity is impacted by the
   conversion of the net assets of international subsidiaries for which
   the functional currency is not the U.S. dollar.  Foreign currency
   exposures are managed on a centralized basis by the Company's Treasury
   Department.  This allows for the netting of natural offsets and lowers
   transaction costs and exposures.  Bio-Rad currently makes
   approximately 50% of its sales outside the United States and weakening
   in one currency can often be offset by strengthening in another.

   Bio-Rad typically enters into forward exchange contracts to sell its
   foreign currency.  Contracts are entered into typically for 30 to 60
   days, primarily in British Sterling, Japanese Yen, Italian Lira and
   German Marks.  The costs are recognized in income monthly and
   generally are the reciprocal of the change in underlying assets.  Bio-
   Rad does not hold any derivative contracts that hedge its foreign
   currency denominated net asset exposures.

   Bio-Rad uses sensitivity analysis to assess the market risk associated
   with its foreign currency exchange risk.  Market risk is the potential
   change in fair value of derivative positions from an adverse movement

                                     31
   <PAGE>

   in currency exchange rates.  The forward foreign exchange contracts at
   December 31, 1998 had a net fair value of $46 million.  A 10% adverse
   loss on quoted foreign currency exchange rates would result in a $4.6
   million loss.  This impact, of a change in exchange rates, excludes
   from the analysis the offset derived from the change in the Company's
   underlying assets and liabilities, which could reduce the effect to
   zero.

   The Company maintains a percentage of fixed and variable rate debt
   within parameters subject to review by the Board of Directors.  The
   Treasury Department enters into swap agreements replacing a segment of
   its variable rate debt with fixed rate debt.  At December 31, 1998,
   two swaps existed for $25 million.  The agreements mature in December
   2000, and June 2002 and have an interest rate of 6.3%.  The debt
   swapped was borrowings under the Company's principal revolving credit
   agreement.  The additional cost to fix $25 million of the Company's
   floating rate debt was expensed as incurred.

   New Financial Accounting Standards

   In June 1998, the Financial Accounting Standards Board (FASB) issued
   Statement of Financial Accounting Standards (SFAS) No. 133,
   "Accounting for Derivative Instruments and Hedging Activities"
   effective for fiscal years beginning after June 15, 1999, with early
   adoption permitted.  This statement establishes accounting and
   reporting standards requiring companies to record all derivatives on
   the balance sheet as either assets or liabilities and measure those
   instruments at fair value.  The manner in which companies are to
   record gains or losses resulting from changes in the values of those
   derivatives depends on the use of the derivative and whether it
   qualifies for hedge accounting.  The impact of SFAS No. 133 on the
   Company's financial statements will depend on a variety of factors,
   including future interpretive guidance from the FASB, the future level
   of forecasted and actual foreign currency transactions, the extent of
   the Company's hedging activities, the types of hedging instruments
   used and the effectiveness of such instruments.  However, the Company
   does not expect the effect of adopting SFAS No. 133 to have a material
   effect on its financial statements.

   Forward Looking Statements

   Other than statements of historical fact, statements made in this
   Annual Report include forward looking statements, such as statements
   with respect to the Company's future financial performance, operating
   results, plans and objectives.  Actual results may differ materially
   from those currently anticipated depending on a variety of risk
   factors including increased competition, technological development,
   access to necessary intellectual property, the ability to achieve
   management objectives (especially related to SG&A and inventory),
   government regulation, the continued performance of business partners
   (particularly in relation to the Year 2000 issue), and the monetary
   policies of various countries.




                                     32


   <PAGE>

   EXHIBIT 21.1 - LISTING OF SUBSIDIARIES

   SUBSIDIARY                         JURISDICTION OF ORGANIZATION

   Bio-Rad Laboratories Pty. Limited            Australia
   Bio-Rad Laboratories Ges.m.b.H.              Austria
   Bio-Rad International, Inc. (FSC)            Barbados
   Bio-Rad Laboratories S.A.-N.V.               Belgium
   RSL N.V.                                     Belgium
   Bio-Metrics Properties Limited               California, USA
   Bio-Rad Laboratories (Israel) Inc.           California, USA
   Bio-Rad Leasing, Inc.                        California, USA
   Bio-Rad Pacific Limited                      California, USA
   Bio-Rad Laboratories (Canada) Ltd.           Canada
   Beijing Bio-Rad Analytical
     Biochemistry Instrument Co., Ltd.          China
   SoftShell International Ltd.                 Colorado, USA
   Bio-Metrics Limited                          Delaware, USA
   Bio-Rad Export, Inc. (DISC)                  Delaware, USA
   Bio-Metrics (U.K.) Limited                   England
   Bio-Rad Laboratories Europe Limited          England
   Bio-Rad Laboratories Limited                 England
   Bio-Rad Lasersharp Limited                   England
   Bio-Rad Limited                              England
   Bio-Rad Micromeasurements Limited            England
   Bio-Rad Microscience Limited                 England
   Micromeasurements Limited                    England
   Sadtler Research Laboratories Ltd.           England
   Bio-Rad S.A.                                 France
   Bio-Rad Laboratories GmbH                    Germany
   Bio-Rad China Limited                        Hong Kong
   Bio-Rad Laboratories (India) Private Limited India
   Bio-Rad Laboratories Ltd.                    Israel
   Bio-Rad Laboratories S.r.l.                  Italy
   Nippon Bio-Rad Laboratories K.K.             Japan
   Bio-Rad Korea Ltd.                           Korea
   Bio-Rad Micromeasurements Inc.               Massachusetts, USA
   Bio-Rad Laboratories Mexico, S.A. de C.V.    Mexico
   Bio-Rad Laboratories B.V.                    The Netherlands
   Sandia Systems, Inc.                         New Mexico, USA
   Polaron Instruments, Inc.                    Pennsylvania, USA
   Bio-Rad Laboratories Ltd.                    Russia
   Bio-Rad Laboratories (Singapore) Limited     Singapore
   Bio-Rad Laboratories S.A.                    Spain
   Bio-Rad Laboratories AB                      Sweden
   Bio-Rad Laboratories AG                      Switzerland




   <PAGE>

   EXHIBIT 23.1 - CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


   As independent public accountants, we hereby consent to the
   incorporation of our reports included or incorporated by
   reference in this Form 10-K, into the Company's previously filed
   Registration Statements on Form S-8 (File Nos. 33-53335 and
   33-53337).  It should be noted that we have not audited any
   financial statements of the Company subsequent to December 31,
   1998 or performed any audit procedures subsequent to the date of
   our report.



                                      /s/  Arthur Andersen LLP
                                           ARTHUR ANDERSEN LLP

   San Francisco, California,
     March 25, 1999



<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
   This schedule contains summary financial information extracted
   from Bio-Rad Laboratories, Inc. Form 10-K for the year ended
   December 31, 1998 and is qualified in its entirety by reference
   to such financial statements.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               DEC-31-1998
<CASH>                                           10,081
<SECURITIES>                                          0
<RECEIVABLES>                                   109,639
<ALLOWANCES>                                      3,629
<INVENTORY>                                      92,411
<CURRENT-ASSETS>                                235,389
<PP&E>                                          198,175
<DEPRECIATION>                                  116,045
<TOTAL-ASSETS>                                  367,299
<CURRENT-LIABILITIES>                            97,244
<BONDS>                                          42,339
                                 0
                                           0
<COMMON>                                         12,427
<OTHER-SE>                                      201,907
<TOTAL-LIABILITY-AND-EQUITY>                    367,299
<SALES>                                         441,942
<TOTAL-REVENUES>                                441,942
<CGS>                                           202,438
<TOTAL-COSTS>                                   202,438
<OTHER-EXPENSES>                                      0
<LOSS-PROVISION>                                      0
<INTEREST-EXPENSE>                                3,731
<INCOME-PRETAX>                                  34,228
<INCOME-TAX>                                      9,926
<INCOME-CONTINUING>                              24,302
<DISCONTINUED>                                        0
<EXTRAORDINARY>                                       0
<CHANGES>                                             0
<NET-INCOME>                                     24,302
<EPS-PRIMARY>                                     1.98
<EPS-DILUTED>                                     1.97
        

</TABLE>


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