BIO RAD LABORATORIES INC
8-K, 1999-07-16
LABORATORY ANALYTICAL INSTRUMENTS
Previous: BAUSCH & LOMB INC, 8-A12B, 1999-07-16
Next: CAROLINA POWER & LIGHT CO, U-3A-2, 1999-07-16



   <PAGE>




                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C. 20549

                                FORM 8-K

                             CURRENT REPORT

                PURSUANT TO SECTION 13 OR 15(d) OF THE
                    SECURITIES EXCHANGE ACT OF 1934


   Date of Report (Date of earliest event reported)  July 5, 1999


                     BIO-RAD LABORATORIES, INC.
   _________________________________________________________________
           (Exact Name of Registrant as Specified in Charter)


   A Delaware Corporation             1-7928              94-1381833
   _________________________________________________________________
   (State or Other Jurisdiction     (Commission        (IRS Employer
      of Incorporation)              File  Number)  Identification No.)


   1000 Alfred Nobel Drive, Hercules, California               94547
   _________________________________________________________________
   (Address of Principal Executive Offices)                 (Zip Code)

   Registrant's telephone number, including area code  (510)724-7000


                               No Change
   _________________________________________________________________
     (Former Name or Former Address, if Changed Since Last Report)










   <PAGE>

   ITEM 5.  OTHER EVENTS.

        On July 5, 1999, Bio-Rad Laboratories, Inc. ( Bio-Rad ),
        issued a press release, the text of which is attached hereto
        as Exhibit 99.1, announcing that Bio-Rad, Sanofi-Synthelabo
        S.A. ( Sanofi ) and Institut Pasteur ( IP ) have executed a
        definitive purchase agreement, a copy of which is attached
        hereto as Exhibit 2.1, pursuant to which Bio-Rad shall
        acquire Pasteur Sanofi Diagnostics S.A. from Sanofi and IP
        for an aggregate purchase price of $210 million in cash.


   ITEM 7.  FINANCIAL STATEMENTS AND EXHIBITS.

   (c)  Exhibits.

        The exhibits to this report are listed in the accompanying
        Index to Exhibits.































                                   1


   <PAGE>



                               SIGNATURES

   Pursuant to the requirements of the Securities Exchange Act of
   1934, the registrant has duly caused this report to be signed on
   its behalf by the undersigned hereunto duly authorized.

                                 BIO-RAD LABORATORIES, INC.
                                        (Registrant)


   Date:  July 15, 1999          By: /s/ Sanford S. Wadler
                                     Sanford S. Wadler
                                     Vice President, General
                                     Counsel and Secretary






































                                   2


   <PAGE>



                       BIO-RAD LABORATORIES, INC.

                           INDEX TO EXHIBITS

                               ITEM 7(c)


   The following documents are filed as part of this report:

   Exhibit Number      Description

       2.l           Purchase Agreement dated July 3, 1999 between
                     Sanofi-Synthelabo, Institut Pasteur and Bio-Rad
                     Laboratories, Inc. excluding Exhibits and
                     Schedules.  Pursuant to Regulation S-K Item
                     601(b)(2), the Exhibits and Schedules listed in
                     the List of Exhibits & Schedules to the
                     Purchase Agreement have not been filed.  The
                     Registrant agrees to furnish supplementally a
                     copy of any omitted Schedule to the Commission
                     upon request.

      99.1           Press Release dated July 5, 1999 referred to in
                     Item 5 above.



























                                   3


   <PAGE>

             EXHIBIT 2.1    PURCHASE AGREEMENT


    BETWEEN:

    - SANOFI-SYNTHELABO, a French societe anonyme with
    a share capital of 1,461,174,016 Euros, having its principal
    office at 174, avenue de France, 75013 Paris ("Sanofi")
    represented by Mr. Christian Mignon, duly authorized;

    AND:

    - INSTITUT PASTEUR, a public interest private foundation,
    having its principal office at 28, rue du Docteur
    Roux, 75015 Paris ("IP" and, collectively with Sanofi, the
    "Sellers"; each, a "Seller"), represented by Mr. Jean Castex,
    duly authorized;

    AND:

    - BIO-RAD LABORATORIES INC., a company incorporated
    under the laws of Delaware, having its principal office at 1000
    Alfred Nobel Drive, Hercules, California, 94547, represented by
    Mr. David Schwartz, duly authorized (the "Purchaser", each of
    the Purchaser and either Seller, a "Party" and, collectively,
    the "Parties").

    WHEREAS:

    Pasteur Sanofi Diagnostics S.A. ("PSD" or the "Company")
    is a French societe anonyme whose share capital is
    held by Sanofi (73.66%) and IP (26.34%);

    PSD and its controlled Affiliates (the "Subsidiaries"
    and, collectively with the Company, the "Group Companies", as
    the same are listed in Exhibit A) are engaged in studying,
    researching, producing, selling, distributing in-vitro
    diagnostics products, including as licensees, and providing
    services in the field of in-vitro diagnostics (such activities,
    collectively, the "IVD Activities");

    Certain of Sanofi's Affiliates outside of France listed
    in Exhibit B (the "Ancillary Asset Sellers") are also
    engaged in the IVD Activities and hold and use certain assets in
    connection therewith, together with the employment liabilities
    relating thereto (described in Schedule 4.20(a) and in Exhibit
    C) and are parties to certain contracts pertaining to the IVD
    Activities (the "Ancillary Assets");

    The Sellers wish to divest, and the Purchaser wishes
    to acquire, on the terms and subject to the conditions set forth
    in this Agreement, the IVD Activities with a view to the
    development and future growth of the IVD Activities consistent
    with appropriate social policies;

    In furtherance thereof, Sanofi and IP wish to sell,
    transfer, assign and deliver, and the Purchaser wishes to
    purchase, acquire and assume, on the terms and conditions set
    forth in this Agreement, (i) 2,321,153 shares of capital stock
    (the "Shares") representing all of the outstanding share
    capital of the Company except seven (7) shares held by directors
    and employees of the Group Companies and (ii) the Ancillary
    Assets;

    <PAGE>
                                                                   2.

    Accordingly, the Sellers have agreed to waive, in
    connection with the transactions contemplated by this Agreement,
    all their respective rights under the Shareholders' Agreement,
    which will terminate upon the closing of the sale of the Shares
    contemplated hereby.

    NOW, THEREFORE, in consideration of the mutual representations,
    warranties, covenants, agreements and undertakings contained or
    referred to in this Agreement, and subject to the satisfaction
    or waiver of the conditions of this Agreement, the Parties
    hereby agree as follows.

                             ARTICLE 1
                            DEFINITIONS

    Capitalized terms used in this Agreement are used as
    defined in this Article 1 or elsewhere in this Agreement.
    References in this Agreement to numbered Articles, Sections,
    Exhibits or Schedules are, unless otherwise specified,
    respectively references to Articles and Sections of, and
    Exhibits and Schedules to, this Agreement.

    "Accounting Group" means the Company, the Subsidiaries and
    the Ancillary Assets;

    "Accounting Principles" means (a) Sanofi's accounting
     practices, conforming to accounting principles generally
     accepted in France, as consistently applied by the Sanofi
     Group during the 1997 and 1998 fiscal years and as further
     described in Schedule 4.7(a)(ii) and (b) the accounting
     practices specific to the IVD Activities as set forth in
     Schedule 4.7(a)(iii);

    "Affiliate" means, with respect to any Party, any
    Entity controlling, controlled by, or under common control with
    said Party, in all cases directly or indirectly; for purposes of
    this definition "control" shall have the meaning set forth in
    Article 355-1 of French law no. 66-537 of July 24, 1966 relating
    to commercial companies;

    "Ancillary Asset Employees" has the meaning set forth
    in Section 7.1;

    "Ancillary Asset Purchase Price" means, in the aggregate,
    thirty four million two hundred nineteen thousand (34,219,000)
    French Francs, i.e., US$ five million three hundred forty-two
    thousand three hundred seventy-four (5,342,374), corresponding
    to the aggregate net book value, as of December 31, 1998, of
    the assets included in the Ancillary Assets, after deduction
    of the Ancillary Asset Employees liabilities recorded in the
    Ancillary Asset Sellers' books as of May 31, 1999 and
    allocated among the Ancillary Assets as set forth in Exhibit C;

    "Ancillary Asset Sellers" has the meaning ascribed to
    such term in the preamble hereof;

    "Ancillary Assets" has the meaning ascribed to such
    term in the preamble hereof; it being specified that the net
    book value of the assets included in the Ancillary Assets shall
    exceed the amount (in absolute terms) of the employment
    liabilities relating to the Ancillary Asset Employees;

    "Business" has the meaning set forth in Section 5.7(a);

    "Business Day" means any day other than a Saturday or
    Sunday or other day that commercial banks generally are closed
    in France and, for the purposes of Article 7 only, in France and
    any other jurisdiction from or to or through which a payment is
    to be made in connection with the transactions described in such
    Article;

    <PAGE>
                                                                   3.

    "Calculation Method" means the method used for the
    calculation of the Consolidated Reference Net Worth, as set
    forth in Exhibit D;

    "Change of Control Contracts" has the meaning set
    forth in Section 5.2;

    "Claim" has the meaning set forth in Section 8.2;

    "Closing" has the meaning set forth in Section 9.1(a);

    "Closing Date" has the meaning set forth in Section 9.1(a);

    "Closing Date Amount" has the meaning set forth in Section 6.1(b);

    "Closing Date Calculation" means the method used for
    the calculation of the Consolidated Closing Date Net Worth, as
    set forth in Exhibit E;

    "Company" has the meaning ascribed to such term in
    the preamble of this Agreement;

    "Confidentiality Agreement" has the meaning set forth
    in Section 10.2;

    "Consolidated Financial Statements", in respect of
    any fiscal year, means the consolidated financial statements
    (i.e., the balance sheet and the income statement) of the Group
    Companies, in respect of such fiscal year, prepared in
    accordance with the Accounting Principles;

    "Consolidated 1998 Financial Statements" means the
    Consolidated Financial Statements, as of and for the fiscal year
    ended, December 31, 1998; it being specified that such financial
    statements were derived from the consolidated financial
    statements of the Sanofi Group for 1998, audited by Ernst &
    Young;

    "Consolidated EBITDA" means the Earnings before
    Interest, Taxes, Depreciation and Amortizations of the
    Accounting Group, established in accordance with the Accounting
    Principles, pursuant to the calculation method set forth in
    Exhibit G;

    "Consolidated Closing Date Financial Statements"
    means the Consolidated Financial Statements prepared in
    accordance with the provisions of Section 2.1.3(b), as of August
    31, 1999 or September 30, 1999, as the case may be, and for the
    eight-(8-) or nine-(9-) month period then ended, as applicable;

    "Consolidated Closing Date Net Worth" means the
    consolidated net worth of the Group Companies, as of August 31,
    1999 or September 30, 1999, as the case may be, calculated by
    applying the Accounting Principles and the Closing Date
    Calculation on the basis of information contained in the
    Consolidated Closing Date Financial Statements;

    "Consolidated Reference Net Worth" means the amount
    set forth in Exhibit D corresponding to an estimate of the
    consolidated net worth of the Group Companies, as of August 31,
    1999 or, if the Closing Date is not August 31, 1999, as of
    September 30, 1999, calculated by applying the Calculation
    Method and in accordance with the Accounting Principles;

    "Contract" means any contract, agreement, commitment,
    undertaking, lease, license, mortgage, bond, note or other
    agreement, whether written or oral, creating rights or
    obligations, including of a unilateral nature;

    <PAGE>
                                                                   4.

    "Cooperation Agreement" means the agreement entitled
    Convention de Collaboration between IP and PSD, dated July 11,
    1990;

    "Entity" means any corporation, company, association,
    group, partnership or other entity, incorporated or otherwise;

    "Examination Period" has the meaning set forth in
    Section 2.1.3(b)(ii)(aa);

    "Group Companies" means the Company and the Subsidiaries;

    "ICC" has the meaning set forth in Section 11.12;

    "Independent Auditor" has the meaning set forth in
    Section 2.1.3(b)(iii)(aa);

    "Intellectual Property Rights" means (i) all software,
    (ii) all patents, patent applications, registered
    trademarks, trademark applications, tradenames, service marks,
    service mark registrations, service mark applications, service
    names, copyrights and copyright applications, (iii) all trade
    secrets, processes, know-how and formulae and (iv) all
    intellectual property rights to cell lines and monoclonal
    antibodies owned by or licensed to the Group Companies, except
    those covered by the Cooperation Agreement and the IP License
    Agreement and further described in Section 4.10.2 hereof.
    Intellectual Property Rights also include Sanofi IVD Patents.

    "IP" has the meaning set forth in the second introductory
    paragraph of this Agreement;

    "IP Patents and Trademarks" has the meaning ascribed
    to such term in Section 4.10.2;

    "IP License Agreement" means the agreement dated June 30, 1999
    and entered into between PSD and IP for clarification
    purposes, setting forth a list of patents and know-how licensed
    by IP to PSD pursuant to the Cooperation Agreement and the terms
    of such licenses;

    "IVD Activities" has the meaning set forth in the
    preamble to this Agreement;

    "Liens" means all liens, pledges, mortgages, charges,
    security interests, claims, easements, burdens or other
    encumbrances;

    "Loss" has the meaning set forth in Section 8.1(a);

    "Net Closing Date Financial Indebtedness" means the
    sum, as of the Closing Date, as stated in the Consolidated
    Closing Date Financial Statements, of all amounts (except trade
    receivables) owed by the Group Companies to third party lenders
    or to the Sellers or their Affiliates (other than the Group
    Companies) under a loan or a line of credit after deduction of
    (i) any amounts (except trade receivables) owed by such third
    party lenders, the Sellers or their Affiliates to the Group
    Companies under a loan or a line of credit and (ii) any cash
    balance or cash equivalents on hand or on deposit;

    "Net Preliminary Financial Indebtedness" means the
    sum of all amounts (except trade receivables) owed by the Group
    Companies to third party lenders or to the Sellers or their
    Affiliates (other than the Group Companies) under a loan or a
    line of credit, after deduction of (i) any amounts (except trade
    receivables) owed by such third party lenders, the Sellers or

    <PAGE>
                                                                   5.

    their Affiliates to the Group Companies under a loan or a line
    of credit and (ii) any cash balance or cash equivalents on hand
    or on deposit, on the tenth Business Day preceding the Closing
    Date and notified to the Purchaser no later than three (3)
    Business Days prior to the Closing Date;

    "Notice of Objection" has the meaning set forth in
    Section 2.1.3(b)(ii)(bb);

    "Permitted Encumbrances" shall mean any (i) non material
    easements and security attachments on non material assets and
    (ii) Liens that will be released before Closing;

    "Preliminary Amount" has the meaning set forth in
    Section 6.1(b); it being specified that this amount may not
    exceed US$ two hundred and ten million (210,000,000);

    "Proforma 1998 Financial Statements" means the balance sheet
    and the income statement for the Accounting Group obtained
    by combining (i) the consolidated financial statements
    of the Group Companies prepared in accordance with the
    Accounting Principles and (ii) the assets, liabilities, income
    and expense relating to the Ancillary Assets, as of, and for the
    fiscal year ended, December 31, 1998, as referred to in the
    letters of Ernst & Young dated April 22, 1999, attached hereto
    as Exhibit F; it being specified that such financial statements
    were derived from the consolidated financial statements of the
    Sanofi Group for 1998, audited by Ernst & Young.

    "PSD" has the meaning ascribed to it in the preamble hereof;

    "Purchaser" has the meaning set forth in the third
    introductory paragraph hereof;

    "Purchaser's Auditor" has the meaning set forth in
    Section 2.1.3(b)(ii)(aa);

    "Real Estate" has the meaning set forth in Section 4.8(a);

    "Sanofi" has the meaning set forth in the first introductory
    paragraph hereof;

    "Sanofi Group" means, collectively, Sanofi and its Affiliates
    (excluding the Group Companies);

    "Sanofi IVD Patents" has the meaning set forth in Section 5.6;

    "Sellers" has the meaning set forth in the second introductory
    paragraph hereof;

    "Sellers' Auditor" has the meaning set forth in Section 2.1.3(b)(i);

    "Share Purchase Price" means US$ two hundred and ten
    million (210,000,000) less the Ancillary Asset Purchase Price
    and the Preliminary Net Financial Indebtedness; it being
    specified that the Share Purchase Price may not be increased and
    that the sum of the Share Purchase Price, as may be adjusted
    pursuant hereto, the Ancillary Asset Purchase Price, as may be
    adjusted pursuant hereto and the Closing Date Amount shall not
    exceed US$ 210,000,000;

    "Share Purchase Price Adjustment" has the meaning set
    forth in Section 2.1.3(a);

    "Shareholders' Agreement" means the agreement entered
    into between Sanofi and IP with respect to the Company dated
    July 11, 1990;

    "Shares" has the meaning set forth in the preamble hereof;

    <PAGE>
                                                                   6.

    "Subsidiaries" means the companies controlled by the Company,
    i.e., companies of which the Company holds, directly or
    indirectly, more than 50% of the voting rights;

    "12 Month EBITDA" has the meaning set forth in Section 4.7(c) hereof;

    "Taxes" means all French and foreign taxes, assessments,
    social charges, duties, fees or other governmental
    charges, taxes imposed on or measured by income, taxes based on
    employment (including amounts withheld from employees'
    compensation, including but not limited to social security
    contributions) and any other taxes imposed on or measured by
    property, franchise, sales, customs, gross receipts, profits,
    licenses, premium, withholding, capital, general corporate,
    whether imposed by any national state, government or any
    political subdivision or municipality thereof, including any
    interest, penalty or addition thereto;

    "US Subsidiaries" has the meaning ascribed to such term in
    Section 4.12(a).


                             ARTICLE 2
        SALE AND PURCHASE OF THE SHARES AND ANCILLARY ASSETS

    2.1    The Shares

    2.1.1  Sale and Purchase of the Shares

    Subject to the terms and conditions of this Agreement,
    each Seller agrees to sell, transfer, assign and deliver to the
    Purchaser, and the Purchaser agrees to purchase and acquire (or
    cause any Entity designated by it pursuant to Section 11.3 to
    purchase and acquire) from each of the Sellers the Shares that
    it holds, free and clear of all Liens of any nature whatsoever,
    together with all rights attaching thereto.

    2.1.2  Share Purchase Price

    The Shares shall be sold in consideration for the
    Share Purchase Price as such price may be adjusted pursuant to
    the provisions of Section 2.1.3.

    On the Closing Date, the Purchaser (or its designee)
    shall pay and allocate the Share Purchase Price among the
    Sellers prorata to the respective number of Shares sold by each
    of them.

    Such payment shall be made by means of wire transfer,
    for value on the Closing Date.

    2.1.3  Share Purchase Price Adjustment

    (a) Definition

        The Share Purchase Price shall be reduced, as the case
        may be, in accordance with the following provisions (the "Share
        Purchase Price Adjustment"):

            (i) In the event that the amount of the Consolidated
                Closing Date Net Worth is less than the
                Consolidated Reference Net Worth, the Share

    <PAGE>
                                                                   7.

                Purchase Price shall be reduced by an amount
                equal to the difference between these two
                amounts;

           (ii) In the event that the Net Preliminary Financial
                Indebtedness is less than the Net Closing Date
                Financial Indebtedness, the Share Purchase Price
                shall be reduced by an amount equal to the
                difference between these two amounts.

    (b) Determination of the Share Purchase Price Adjustment

            (i) Preparation of the Consolidated Closing Date
                Financial Statements:

                No later than sixty (60) days after the Closing
                Date, Sanofi shall deliver to the Purchaser (x)
                the audited Consolidated Closing Date Financial
                Statements, (y) a report from Ernst & Young (the
                "Sellers' Auditor") with respect thereto and
                (z) an explanation of their calculation of the
                Share Purchase Price Adjustment based on the
                Consolidated Closing Date Financial Statements
                and the Closing Date Calculation.

                To that effect, the Purchaser shall ensure the
                cooperation of the Group Companies with the
                Sellers' Auditor and shall, in particular, cause
                the Group Companies to provide the Sellers'
                Auditor access to all documents, books, records,
                data and other information of the Group Companies
                necessary in the reasonable opinion of the
                Sellers' Auditor.

           (ii) Review of the Consolidated Closing Date Financial
                Statements:

           (aa) The Purchaser, assisted by PGA - Arthur Andersen
                (the "Purchaser's Auditor"), shall have a
                period of sixty (60) days from the date of
                receipt of the documents referred to in Section
                2.1.2(b)(i) (the "Examination Period") to
                review such documents, conduct its own audit of
                the Consolidated Closing Date Financial
                Statements applying the Accounting Principles and
                notify to Sanofi and to the Sellers' Auditor (the
                "Notice of Objection") that it disagrees with
                the Consolidated Closing Date Financial
                Statements and the calculation of the Share
                Purchase Price Adjustment by Sanofi and the
                Sellers' Auditor, it being specified that (i) the
                opinion of the Purchaser and the Purchaser's
                Auditor on the Share Purchase Price Adjustment
                shall be based on the Closing Date Calculation;
                (ii) the amount of goodwill may not be challenged
                by the Purchaser's Auditors; and (iii) each such
                disagreement may not involve amounts of less than
                five hundred thousand (500,000) French Francs per
                line item of the Consolidated Closing Date
                Financial Statements, and in the aggregate three
                million (3,000,000) French Francs. If the
                aggregate amount is reached, the adjustment will
                be calculated for the entire amount thereof.

           (bb) In the event of such a disagreement, the
                Purchaser shall send a Notice of Objection to
                Sanofi and the Sellers' Auditor, no later than on
                the last day of the Examination Period.  Any
                failure by the Purchaser to send a Notice of
                Objection to Sanofi by such date shall mean that
                the Purchaser has definitively accepted, without
                reservation, all of the terms of the Consolidated
                Closing Date Financial Statements, the Closing
                Date Calculation and the amount of the Share
                Purchase Price Adjustment as calculated by Sanofi

    <PAGE>
                                                                   8.

                and the Sellers' Auditor, and such Consolidated
                Closing Date Financial Statements and such amount
                shall then become final and binding on the
                Parties.

           (cc) The Notice of Objection, if any, shall
                specifically mention each of the proposed
                corrections to be made to the Consolidated
                Closing Date Financial Statements, the Closing
                Date Calculation and the Share Purchase Price
                Adjustment, and shall state the reasons therefor.
                All items of the Consolidated Closing Date
                Financial Statements and the Closing Date
                Calculation not objected to by the Purchaser in
                the Notice of Objection shall be deemed to have
                been accepted by the Purchaser and shall be final
                and binding on the Parties and the Independent
                Auditor (as hereinafter defined).

           (dd) In the event that a Notice of Objection is sent
                to Sanofi, Sanofi and the Purchaser shall
                promptly attempt to reach agreement on the
                portion of the Consolidated Closing Date
                Financial Statements objected to by the Purchaser
                and the Share Purchase Price Adjustment
 .
          (iii) Independent Determination of the Share Purchase
                Price Adjustment:

           (aa) In the event that no agreement has been reached
                between the Parties thirty (30) days after the
                date of receipt by Sanofi of the Notice of
                Objection, those points on which there is
                disagreement shall, at the request of either of
                the Parties, be submitted to Deloitte Touche
                Tomatsu (the "Independent Auditor"), who shall
                act as an expert in accordance with the
                provisions of Article 1592 of the French Civil
                Code.

                Each Party hereby confirms that neither it nor
                any of its Affiliates has, or, to its best
                knowledge, expects to have in the near future,
                any relationship with the Independent Auditor
                (anywhere in the world) which could reasonably be
                considered to cause a potential conflict of
                interest.

                If the Independent Auditor does not accept its
                appointment or is prevented from carrying out its
                duties, the Parties shall promptly meet to agree
                on a replacement and each Party may, at any time,
                pursuant to a refere proceeding, request the
                President of the Commercial Court of Paris to
                appoint the Paris office of another accounting
                firm of international reputation meeting the
                foregoing requirement of independence as
                Independent Auditor, preferably chosen among
                PriceWaterhouseCoopers or KPMG.

           (bb) The Independent Auditor shall perform such
                procedures as it considers appropriate to form an
                independent opinion on the components of the
                Consolidated Closing Date Financial Statements,
                the Closing Date Calculation and the final
                calculation of the Share Purchase Price
                Adjustment which were not agreed upon between the
                Parties.  In making its determinations, the
                Independent Auditor shall apply the Accounting
                Principles and the Calculation Method.

                The Parties shall use their best efforts to cause
                the Independent Auditor to issue a report setting
                forth the final calculation of the Share Purchase

    <PAGE>
                                                                   9.

                Price Adjustment in accordance with this Section
                2.1.2 within thirty (30) days from the date of
                the appointment of the Independent Auditor.  The
                Independent Auditor's calculation of the Share
                Purchase Price Adjustment shall be final and
                binding on the Parties.

           (cc) Each of Sanofi and the Purchaser shall use its
                respective best efforts to ensure that the
                Sellers' Auditor and the Purchaser's Auditor
                shall cooperate with the Independent Auditor,
                including by granting access to all relevant
                working papers and files.  The Purchaser shall
                further ensure the cooperation of the Group
                Companies with the Independent Auditor and shall,
                in particular, cause the Group Companies to give
                the Independent Auditor access to all relevant
                documents, books, records, data and other
                information of the Group Companies.

           (dd) The Independent Auditor's fees and disbursements
                shall be borne equally by the Sellers on one hand
                (and, among the Sellers, in proportion to the
                respective number of Shares sold by each of them)
                and the Purchaser on the other hand.

    (c) Payment of the Share Purchase Price Adjustment

        In the event of a Share Purchase Price Adjustment
        resulting in a reduction of the Share Purchase Price, each
        Seller shall pay to the Purchaser a portion of the Share
        Purchase Price Adjustment, corresponding to the proportion of
        the respective number of Shares sold by each of them.

             Such payment shall be made:

             -   within fifteen (15) days after the Share Purchase
                 Price Adjustment is finally determined as
                 provided above;

             -   by transfer of immediately available funds in
                 French Francs, to an account designated by the
                 recipient(s) thereof.

    2.2    Ancillary Assets

    2.2.1  Sale and Purchase of the Ancillary Assets

    Subject to the terms and conditions of this Agreement,
    Sanofi undertakes to cause the Ancillary Asset Sellers to sell,
    transfer, assign and deliver to the Purchaser and the Purchaser
    agrees to purchase and acquire (or cause any Entity(ies)
    designated by it and agreed by the Sellers to purchase and
    acquire) from them and assume, the Ancillary Assets, free and
    clear from all Liens of any nature whatsoever, except for
    Permitted Encumbrances.

    2.2.2  Ancillary Asset Purchase Price

    Each of the Ancillary Assets shall be sold in consideration
    for the relevant Ancillary Asset Purchase Price, as may be
    adjusted pursuant to the provisions of Section 2.2.3.

    On the Closing Date or, in respect of those Ancillary
    Assets subject to prior reorganization as contemplated by
    Section 7.3(b) or whose transfer shall not have received all
    required regulatory approvals prior to the Closing Date, on the

    <PAGE>
                                                                   10.

    relevant subsequent date of transfer thereof, the Purchaser (or
    its designee(s)) shall pay the Ancillary Asset Purchase Price in
    respect of any transferred Ancillary Asset to the relevant
    Ancillary Asset Seller or to Sanofi acting on behalf of the
    relevant Ancillary Asset Seller.

    All such payments shall be made by means of wire
    transfer, for value on the Closing Date or, as the case may be,
    on the relevant subsequent closing date to be agreed upon
    between the Parties.  Any such payments made in respect of
    Ancillary Assets shall be made in French Francs or, if
    applicable law so requires or if the Purchaser has designated an
    Entity to purchase the relevant Ancillary Assets which is
    located in the same country as the relevant Ancillary Asset
    Seller, in the currency of the country in which the relevant
    Ancillary Asset Seller is located.  Amounts to be paid in a
    currency other than French Francs, if applicable, shall be
    calculated by applying (i) the applicable indicative exchange
    rate published by the Bank of France for the tenth (10th)
    Business Day preceding the relevant payment date, a copy of
    which the Sellers shall communicate to the Purchaser and (ii)
    the parity between French Francs and Euros.

    2.2.3  Ancillary Asset Purchase Price Adjustment

    The Ancillary Asset Purchase Price relating to each
    Ancillary Asset shall be reduced or increased, as the case may
    be, in accordance with the following provisions; provided,
    however, that any increase in the Ancillary Asset Purchase Price
    pursuant to this Section 2.2.3 shall be limited to the amount of
    the Share Purchase Price Adjustment, if any, that may be finally
    determined pursuant to Section 2.1.3 above.  In the event that
    such increase shall exceed the amount of the Share Purchase
    Price Adjustment, such excess shall be deemed to reduce the
    Share Purchase Price, for purposes of the allocation of the
    Purchase Price among the Sellers and the Ancillary Asset
    Sellers.

    Within fifteen (15) days from the Closing Date or, as
    the case may be, from the subsequent date of transfer of the
    relevant Ancillary Asset agreed upon between the Parties, Sanofi
    shall notify to the Purchaser (or its designee(s)) the net book
    value of the relevant Ancillary Asset and the related Ancillary
    Asset Employers' liabilities as stated in the relevant Ancillary
    Asset Seller's books, as at the date of transfer of such
    Ancillary Asset and Ancillary Asset Employers, converted, as the
    case may be, into French Francs, at the exchange rate referred
    to in Section 2.2.2, as applicable on such date.

    If such net book value exceeds the relevant Ancillary
    Asset Purchase Price, the Purchaser (or its designee(s)) shall
    pay to the relevant Ancillary Asset Seller the amount of the
    difference between these two amounts.

    If such net book value is less than the relevant
    Ancillary Asset Purchase Price, the relevant Ancillary Asset
    Seller shall refund to the Purchaser (or its designee(s)) the
    amount of the difference between these two amounts.

    The adjustments contemplated by this Section 2.2.3
    shall be calculated by Sanofi and, at the request of the
    Purchaser, may be subject to a contradictory audit pursuant to
    the procedure described in Section 2.1.3 above applied mutatis
    mutandis; provided, however, that the review period available to
    each Party's auditor shall be limited to thirty (30) days.

      The payments provided in the two paragraphs above shall be made:

         - within fifteen (15) days after the net book value
           of the relevant Ancillary Asset has been notified
           to the Purchaser (or its designee(s)) by Sanofi;

    <PAGE>
                                                                   11.

         - by transfer of immediately available funds in the
           currency used for the payment of the relevant
           Ancillary Asset Purchase Price, to an account
           designated by the recipient thereof.

                                ARTICLE 3
                     REPRESENTATIONS OF THE PURCHASER

    The Purchaser hereby makes and gives the following
    representations and warranties for the benefit of the Sellers,
    which shall be accurate in all material respects as of the date
    hereof and (except as otherwise specifically provided therein)
    as of the Closing Date, as though restated on such date.

    3.1    Organization, Authority and Validity

    (a) The Purchaser is (and its designee(s), if any, will be)
        a corporation duly organized and validly existing under
        the laws of Delaware (United States of America).  The Purchaser
        has the corporate power and authority to enter into this
        Agreement and to carry out its obligations hereunder.

    (b) The execution of this Agreement and the consummation of the
        transactions contemplated hereby have been duly authorized
        by the competent corporate bodies of the Purchaser (and will
        have been so authorized by the competent corporate body of
        its designee(s)), and no other corporate action on the part
        of the Purchaser (or any such designee(s)) is (or will be)
        necessary to authorize the execution of this Agreement or
        the consummation of any of the transactions contemplated hereby.

    (c) This Agreement has been duly executed by the Purchaser and
        constitutes a legal, valid and binding obligation of the
        Purchaser, enforceable against it in accordance with its terms.

    3.2    No Breach

    Neither the execution of this Agreement, nor the performance by
    the Purchaser of its obligations hereunder, nor the consummation
    of the transactions contemplated hereby does or will:

        (i) conflict with or violate any provision of the by-
            laws of the Purchaser or any other corporate governance
            document of the Purchaser;

       (ii) violate, conflict with or result in the breach or
            termination of, or constitute a default or an event of
            default under, the terms of any Contract to which the
            Purchaser is a party; or

      (iii) constitute a violation by the Purchaser of any laws or
            regulations.

    3.3    Consents

    The Purchaser is not required to obtain any consent in
    connection with the consummation of any of the transactions
    contemplated hereby.

    <PAGE>
                                                                   12.

    3.4    Brokers

    All negotiations relating to this Agreement and the transactions
    contemplated hereby have been carried out without the intervention
    of any person acting on behalf of the Purchaser in such manner as
    to give rise to any valid claim against any of the Sellers or any
    of their Affiliates for any broker's or finder's fee or similar
    compensation in connection with the transactions contemplated hereby.

                                ARTICLE 4
                      REPRESENTATIONS OF THE SELLERS

    The Sellers hereby make and give the representations and warranties
    contained in Sections 4.4.3, 4.5, 4.6 and 4.15 for the benefit of
    the Purchaser.  In addition, Sanofi hereby makes and gives, for the
    benefit of the Purchaser, the representations and warranties contained
    in Sections 4.1.1, 4.2.1, 4.3.1, 4.4.1, 4.7 through 4.14 and 4.16
    through 4.26 (with the exception of those contained in Section 4.10.2),
    and IP makes and gives, for the benefit of the Purchaser, the
    representations and warranties contained in Sections 4.1.2, 4.2.2,
    4.3.2, 4.4.2 and 4.10.2.  The representations and warranties contained
    in this Article 4 shall be accurate in all material respects as of
    the date hereof and (except as otherwise specifically provided therein)
    as of the Closing Date, as though restated on such date.

    4.1    Organization, Authority and Validity

    4.1.1  (a) Sanofi is a corporation duly organized and validly existing
               under the laws of France.  Sanofi has the power
               and authority to enter into this Agreement and to carry out
               its obligations hereunder.

           (b) The execution of this Agreement and the consummation of
               the transactions contemplated hereby have been duly
               authorized by the competent corporate bodies of Sanofi, and
               no other corporate action on the part of Sanofi is necessary
               to authorize the execution of this Agreement or the
               consummation of any of the transactions contemplated hereby.

           (c) This Agreement has been duly executed by Sanofi and
               constitutes a legal, valid and binding obligation of Sanofi,
               enforceable against it in accordance with its terms.

    4.1.2  (a) IP is a public interest private foundation duly organized
               and validly existing under the laws of France.  IP has
               the power and authority to enter into this Agreement and to
               carry out its obligations thereunder.

           (b) The execution of this Agreement and the consummation of
               the transactions contemplated hereby have been duly
               authorized by the competent organizational bodies of IP,
               and no other action on the part of IP is necessary to
               authorize the execution of this Agreement or the
               consummation of any of the transactions contemplated hereby.

           (c) This Agreement has been duly executed by IP and constitutes
               a legal, valid and binding obligation of IP, enforceable
               against it in accordance with its terms.

    <PAGE>
                                                                   13.

    4.2   No Breach

    4.2.1  Except as set forth in Schedule 4.2.1, neither the execution
    of this Agreement nor the performance by Sanofi of its obligations
    hereunder nor the consummation of the transactions contemplated
    hereby does or will:

          (i) conflict with or violate any provision of the by-laws
              or any other corporate governance document of Sanofi
              or of any Group Company; or

         (ii) to Sanofi's best knowledge, violate, conflict with or
              result in the breach of any Contract to which any Group
              Company is a party; or

        (iii) violate, conflict with or result in the breach of
              any Contract to which Sanofi is a party; or

         (iv) constitute a violation by Sanofi or any Group Company
              of any laws or regulations;

    except for any such matters that would not, either individually
    or in the aggregate, have a material adverse effect on the
    financial condition of the Group Companies or materially impair
    the ability of Sanofi to perform its obligations under this
    Agreement.

    4.2.2  Except as set forth in Schedule 4.2.2, neither the execution
    of this Agreement nor the performance by IP of its obligations
    hereunder nor the consummation of the transactions contemplated
    hereby does or will:

          (i) conflict with or violate any provision of the by-laws
              or any other corporate governance document of IP or of
              any Group Company; or

         (ii) to IP's best knowledge, violate, conflict with or
              result in the breach of any Contract to which any
              Group Company is a party; or

         iii) violate, conflict with or result in the breach of
              any Contract to which IP is a party; or

         (iv) constitute a violation by IP or any Group Company
              of any laws or regulations;

    except for any such matters that would not, either individually
    or in the aggregate, have a material adverse effect on the
    financial condition of the Group Companies or materially impair
    the ability of IP to perform its obligations under this
    Agreement.

    4.3    Consents

    4.3.1  No consent is required to be obtained by Sanofi or any
    Group Company other than those set forth in Schedule
    4.3.1 for purposes of the execution of this Agreement or the
    consummation of any of the transactions contemplated herein.

    4.3.2  No consent is required to be obtained by IP or any Group
           Company other than those set forth in Schedule 4.3.2
           for purposes of the execution of this Agreement or the
           consummation of any of the transactions contemplated herein.

    <PAGE>
                                                                   14.

    4.4    Incorporation, Existence and Authority of the Group Companies

    4.4.1  Sanofi owns, either directly or indirectly, the number of
    shares in the Company and its Subsidiaries set forth in Schedule 4.4.1.

    4.4.2  IP owns, either directly or indirectly, the number of shares
    in the Company and its Subsidiaries set forth in Schedule 4.4.2.

    4.4.3  (a) Schedule 4.4.3(a) contains an accurate and complete list
               of the Group Companies indicating the jurisdiction
               of incorporation thereof.

           (b) Each of the Group Companies, is duly organized,
               and validly existing under the laws of its jurisdiction of
               incorporation.

           (c) Each of the Group Companies has full power and authority
               to own, lease and operate the assets held or used by
               it, and carry out its activities in the manner in which
               they are currently carried out.

           (d) Except as set forth in Schedule 4.4.3(d), none of the
              Group Companies currently is the subject of any voluntary or
              judicial reorganization proceedings, or similar proceedings
              or is undergoing a liquidation.

    4.5    Capital Structure

           (a) All of the Shares and all of the shares and other equity
               interests in the Group Companies are validly issued and
               fully paid.  Except as set forth in Schedule 4.5(a),
               the Shares and all of the shares and other equity
               interests in the Subsidiaries are free and clear of all Liens.

           (b) The share capital of each of the Group Companies
               is set forth in Schedule 4.4.3(a).  Except as set forth in
               Schedule 4.4.3(a), there are no warrants, subscription, option
               or conversion rights or other agreements, securities, or other
               commitments, of any nature whatsoever authorized or outstanding
               pursuant to which any of the Group Companies is or may become
               obligated to issue or sell any shares, warrants or other
               securities of any nature whatsoever.  Except as set forth in
               Schedule 4.4.3(a), the Group Companies do not hold any interest
               in any Entity.

    4.6    Transferability of the Shares

    The Shares represent 99,99% of the share capital of, and of the
    voting rights in, the Company.  The Shares are owned respectively
    by Sanofi and IP, in the respective numbers and proportions as set
    forth in Schedule 4.6.  Each Seller represents and warrants with
    respect to its respective Shares, that the Shares held by it may be
    freely disposed by it without any restrictions whatsoever other
    than those resulting from the clause d'agrement contained in
    Article 10(a) of the by-laws of the Company and that it has agreed to
    waive its right of first refusal over the Shares provided under
    Section 2.3.1 of the Shareholders' Agreement.

    4.7    Financial Statements

           (a) The Proforma 1998 Financial Statements are attached hereto
               as Schedule 4.7(a)(i).  The Proforma 1998 Financial Statements
               fairly present, in accordance with the Accounting Principles,
               which are attached hereto as Schedule 4.7(a)(ii) and

    <PAGE>
                                                                   15.

               4.7(a)(iii), applied on a consistent basis, the financial
               condition, assets and liabilities of the Accounting
               Group as of December 31, 1998 and for the fiscal year then
               ended.  As of December 31, 1998, the Group Companies did not
               have any material liabilities other than liabilities reflected
               or reserved against in the Proforma 1998 Financial Statements
               or disclosed in Schedule 4.7(a)(iv).

           (b) Except as set forth in Schedule 4.7(b)(ii),the Group
               Companies, since December 31, 1998, (i) have conducted
               their businesses only in the ordinary course of business in a
               manner consistent with past practice, have not changed the
               senior management referred to in Schedule 4.7(b)(i) and
               have not taken any of the actions described in Section 5.1
               below and (ii) have not incurred any liability or financial
               obligation except liabilities (aa) incurred in the ordinary
               course of business consistent with past practice, or
               (bb) individually amounting to no more than FRF. 500,000,
               or (cc) specifically reserved against (whether in a general
               reserve account or in a specific reserve account) or otherwise
               reflected in the Consolidated 1998 Financial Statements.
               All reserves made in the Proforma 1998 Financial Statements
               are adequate in all material respects.

           (c) The Consolidated EBITDA of the Accounting Group for the
               12-month period ended as of June 30, 1999 (the "12-Month
               EBITDA"), as calculated by Ernst & Young, shall be not
               less than US$ 7,000,000 (once converted from French Francs
               (until December 31, 1998) or Euros (from January 1, 1999)
               at the weighted average exchange rate between FRF or Euros
               and US$ for each monthly period included in such 12-month
               period).  For purposes of Article 8 hereof, any shortfall
               between the 12-Month EBITDA and the above-referred amount
               shall entitle the Purchaser to indemnification in the amount
               of five (5) times such shortfall, subject to the provisions
               of Article 8 hereof (including any limitations contained
               therein).

    4.8    Real Estate

           (a) A complete list of all real estate owned or leased by the
               Group Companies is attached hereto as Schedule 4.8(a),
               including all land and buildings used for purposes of
               carrying out the activities of the Group Companies (all such
               real estate, the "Real Estate").

           (b) Except as set forth in Schedule 4.8(b), the Real Estate
               owned by the Group Companies is free and clear of all
               Liens (other than Permitted Encumbrances) which may
               significantly affect their value or use.

           (c) Except as set forth in Schedule 4.8(c), the Real Estate
               not owned by the Group Companies is leased pursuant to
               valid lease agreements.  None of the Group Companies have
               been notified that they are in breach of any of these lease
               agreements which permits the Group Companies to continue
               to use the leased Real Estate in the same manner as is
               currently being used.

    4.9    Movable Property, Businesses ("Fonds de Commerce") and Inventory

           (a) Except as set forth in Schedule 4.9(a), all movable
               property, installations and equipment used by the Group
               Companies to conduct their businesses are either (i) fully
               owned by the Group Companies and are not the subject of
               any Liens other than Permitted Encumbrances or (ii) are
               used by the Group Companies under the terms of a valid lease,
               operating lease (location financiere) or capital lease
               (credit bail) agreement. Except as reflected in the Financial
               Statements of the Group Companies (and particularly in the
               reserves accounted for by the Group Companies), substantially
               all movable property, installation and equipment used by the
               Group Companies to conduct their businesses are in good
               operating condition and repair, ordinary wear and tear
               excepted, and are fit for the purposes for which they are
    <PAGE>
                                                                   16.

               currently being used in the Group Companies businesses.
               There exists no restriction on the use or transfer of
               the movable property, installations and equipment used
               by the Group Companies, except for regulatory requirements
               as well as third parties rights under lease or operating
               lease agreements.

           (b) Except as set forth in Schedule 4.9(b), the businesses
               ("fonds de commerce") of the Group Companies have in
               all material respects been operated in accordance with
               currently applicable laws and regulations.  Except as set
               forth in Schedule 4.9(b), the Group Companies have full
               ownership of such businesses, which are not subject to
               any Liens other than Permitted Encumbrances.  The
               businesses ("fonds de commerce") of the Group Companies
               have sufficient assets to carry on their respective businesses
               as presently conducted.

           (c) Except as reflected in the Financial Statements of the
               Group Companies (and particularly in the specific
               reserves accounted for by the Group Companies (whether in a
               general reserve account or in a specific reserve account)),
               all product inventory held by the Group Companies is in good,
               marketable and usable condition, free from all Liens, and
               is in conformity with warranties customarily given to
               purchasers of the relevant products.  All inventory is managed
               in a manner consistent with past practice.

    4.10   Intellectual Property Rights

    4.10.1 (a) Schedule 4.10.1(a) sets forth (i) a complete list of all
               patents, patent applications, registered trademarks,
               trademark applications owned by the Group Companies [and]
               (ii) a complete list of all licenses granted to the Group
               Companies in connection with patents, patent applications,
               registered trademarks, trademark applications, know-how
               and intellectual property rights to monoclonal antibodies,
               except for those covered by the Cooperation Agreement and
               the IP License Agreement, (iii), for information purposes
               only, a list of certain cell lines and monoclonal antibodies
               registered with ATCC or other similar scientific depositary
               bodies, all of which are owned or validly used by the Group
               Companies, and (iv) Schedule 5.6 sets forth all intellectual
               property rights owned by Sanofi and used by the Group
               Companies in their IVD Activities, and there is no other
               intellectual property of Sanofi required by the Group
               Companies for them to conduct the IVD Activities, as
               currently being conducted.

           (b) Except as set forth in Schedule 4.10.1(b) (and except for
               the Sanofi IVD Patents), each of the Group Companies
               (or Sanofi for the Sanofi IVD Patents) either owns or uses
               pursuant to license agreements the Intellectual Property
               Rights and none of the Intellectual Property Rights owned
               by the Group Companies (or by Sanofi for Sanofi IVD Patents)
               are subject to any Liens or have been revoked or held invalid
               or unenforceable or have become abandoned as a result of
               non-compliance with the formalities required to maintain them
               in full force and effect or as the result of the failure to
               use such Intellectual Property Rights;

           (c) Except as set forth in Schedule 4.10.1(c) and except for
               Sanofi IVD Patents, the Group Companies (or Sanofi
               for Sanofi IVD Patents) have good and valid title to the
               Intellectual Property Rights owned by them;

           (d) Except as set forth in Schedule 4.10.1(d) (and except
               for the Sanofi IVD Patents following transfer thereof to
               the Group Companies), none of the Group Companies (or
               Sanofi for the Sanofi IVD Patents, subject to the provisions
               of Section 5.6 hereof) has granted, or agreed to grant, to
               any third party any license or other right to use any of the
               Intellectual Property Rights;

           (e) Except as set forth in Schedule 4.10.1(e), all of the
               Intellectual Property Rights used but not owned by the Group
               Companies are used by the Group Companies pursuant to legally

    <PAGE>
                                                                   17.

               valid license agreements and none of the Group Companies are
               in material breach under any of these agreements, no
               proceeding or claim is currently outstanding or asserted
               against any of the Group Companies (or Sanofi for the
               Sanofi IVD Patents) in respect of the Intellectual Property
               Rights and none of the Group Companies (or Sanofi for the
               Sanofi IVD Patents) have received a notice from a third party
               to the effect that any product that the Group Companies make,
               use, sell or distribute, infringes any trademark, trade name,
               copyright, patent, trade secret or similar legally protected
               right of such third party. In the reasonable opinion of Sanofi,
               based on specific studies having been conducted by the Group
               Companies, the HIV and Hepatitis viruses products currently
               manufactured and/or sold by the Group Companies do not
               infringe any intellectual property right legally protected
               of a third party.

           (f) Except as set forth in Schedule 4.10.1(f), the Group Companies
               are not required by Contract or otherwise to make any
               payments in connection with the ownership or use of the
               Intellectual Property Rights other than (aa) fees payable to
               their intellectual property counsels and to competent
               authorities to maintain their Intellectual Property Rights in
               full force and effect and (bb) with respect to Intellectual
               Property Rights not owned by them, the royalties and cash
               payments provided in the license agreements listed in Schedule
               4.10.1(a)(ii);

           (g) Except as set forth in Schedule 4.10.1(g), the consummation
               of the transactions contemplated hereby will not alter or
               impair any of the Group Companies' rights under license
               agreements pertaining to the Intellectual Property Rights,
               except for such breaches, alterations or impairments that
               would not, either individually or in the aggregate, have a
               material adverse effect on the financial condition of the
               Group Companies taken as a whole.

    4.10.2 (a) Schedule 4.10.2(a)(i) sets forth a complete list of the
               patents, patent applications, registered trademarks,
               trademark applications and know-how owned in whole or in
               part by IP and currently used by all or certain of the Group
               Companies or that the Group Companies are entitled to use, in
               each case in the field of IVD Activities, pursuant to the
               Cooperation Agreement and the IP License Agreement (the
               "IP Patents and Trademarks"); it is specified that those of
               the IP Patents and Trademarks listed in Schedule 4.10.2(a)(ii)
               are licensed to the Group Companies on a non-exclusive basis;

           (b) Except as set forth in Schedule 4.10.2(b), IP owns and has
               good and valid title to the IP Patents and Trademarks, or is
               the valid co-owner of the IP Patents and Trademarks and is
               entitled, pursuant to a management agreement relating thereto,
               to grant licenses, including on an exclusive basis, to
               third-parties with respect to such co-owned IP Patents and
               Trademarks;

           (c) Except as set forth in Schedule 4.10.2(c), none of the IP
               Patents and Trademarks are subject to Liens or have been
               revoked or held invalid or unenforceable or have become
               abandoned as a result of non-compliance with the formalities
               required to maintain them in full force and effect; it is
               specified that Schedule 4.10.2.(c) may be amended with respect
               to trademarks by the Sellers until the Closing Date;

           (d) Except as set forth in Schedule 4.10.2(d), IP has not granted
               or agreed to grant to any third party any license or
               other right to use for the same applications those of the IP
               Patents and Trademarks licensed to the Group Companies on an
               exclusive basis nor have IP or other co-owners of IP Patents
               and Trademarks retained the right to use, for commercial
               purposes, such IP Patents and Trademarks;

           (e) Except as otherwise set forth in Schedule 4.10.2(e), no
               proceeding or claim is currently outstanding against IP
               or the Group Companies in respect of the IP Patents
               and Trademarks.

    <PAGE>
                                                                   18.

    4.10.3 Except as otherwise provided in Sections 4.10.1 and 4.10.2 and
           as may result out of patent applications not published as of
           the date of signing hereof, to the best of Sanofi's knowledge
           after diligent inquiry, the Group Companies hold the Intellectual
           Property Rights and the IP Patents and Trademarks necessary
           to conduct the IVD Activities as currently being conducted.

    4.11   Loans

           (a) Except as set forth in Schedule 4.11(a), none of the Group
               Companies have made any loans to any individual or to
               any legal entity that are outstanding as of the date hereof,
               with the exception of loans to employees or bodies responsible
               for the collection of employers' construction fund
               contributions and loans granted to other Group Companies.

           (b) Except as set forth in Schedule 4.11(b), none of the Group
               Companies is in default with respect to any material
               term or condition of any indebtedness incurred vis-a-vis
               third parties outstanding as of the date hereof.

    4.12   Tax, Social Security and Customs

           (a) For purposes of Sections 4.12, 4.18 and 4.20, the
               term "Group Companies" shall be deemed to exclude Group
               Companies organized under the laws of any State of the United
               States of America, i.e.,  Sanofi Diagnostics Pasteur, Inc.,
               Genetic Systems Corporation, Blood Virus Diagnostics, Inc.
               and Respiratory Diagnostics, Inc., (the "US Subsidiaries") in
               respect of which the representations and warranties set forth
               in Schedule 4.12(a) are made and given.

           (b) Except as set forth in Schedule 4.12(b), (i) the Group
               Companies have filed on a timely basis with the competent
               authorities any and all returns in respect of Taxes which
               they were required to file and such returns were true and
               accurate in all material respects when filed, (ii) all Taxes
               required to be paid by the Group Companies that were due and
               payable prior to the date hereof have been paid by the Group
               Companies and (iii) the Group Companies have made adequate
               provisions in the Proforma 1998 Financial Statements, in
               accordance with the Accounting Principles, for the payment of
               all Taxes that were not due and payable prior to January 1,
               1999 but for which they may be liable in respect of periods
               ending prior to January 1, 1999, regardless of whether the
               liability for such Taxes is disputed.

           (c) Except as set forth in Schedules 4.7(a)(iv) and 4.12(b),
               there are no Liens for Taxes upon the assets of any of
               the Group Companies;

           (d) The Group Companies have never been members of any
               partnerships, joint ventures or interest groupings
               (groupements d'interet economique) under which any of
               the Group Companies may be responsible for any tax
               obligations of any other person or Entity;

           (e) All tax credits, tax losses reported in the tax returns
               are valid and may be taken advantage of by the Group
               Companies under currently applicable tax law;

           (f) Except as set forth in the schedules to Section 4.7,
               the Group Companies have not incurred any Tax liabilities
               for the period beginning January 1, 1999 and ending on the
               Closing Date other than Tax liabilities incurred in the
               ordinary course of their business; and

           (g) Except as set forth in Schedule 4.12(c), none of the Group
               Companies is the subject of a Tax audit or Tax investigation,
               nor have any of the Group Companies received from any Tax

    <PAGE>
                                                                   19.

               authority any notice of such an audit or investigation.
               No claims for unpaid Taxes, interest or penalties are being
               asserted against the Group Companies.  No express waiver of
               any statute of limitations has been given and is currently
               in effect with respect to the assessment of any Taxes against
               the Group Companies.

    4.13    Insurance

           (a) The Group Companies are insured either through group
               policies contracted by Sanofi-Synthelabo or policies directly
               contracted by them in amounts and against those risks
               normally insured against by persons operating similar
               businesses of similar sizes in similar locations
               (including product liability insurance, motor vehicle
               and general liability insurance as well as fire insurance
               and insurance of the properties of the Group Companies.
               A list of such policies contracted by Sanofi-Synthelabo
               is set forth in Schedule 4.13(a).  Such insurance policies
               are in full force and effect in accordance with their
               respective terms and will remain in full force and effect
               until the Closing Date.

           (b) A list of all material pending claims or disputes in
               connection with such insurance policies is attached hereto as
               Schedule 4.13(b).

    4.14   Contracts

           (a) Schedule 4.14(a) contains an accurate and complete list of
               all Contracts (except license agreements pertaining to
               Intellectual Property Rights, a list of which is set forth
               in Schedules 4.10.1(a) and 4.10.1(d)) to which any of the
               Group Companies is a party that (i) involve the obligation
               (including contingent obligations) by or to any of the Group
               Companies to pay amounts in excess of one million (1,000,000)
               French Francs in any year (on the basis of the Proforma 1998
               Financial Statements) or (ii) were not entered into in the
               ordinary course of business of the Group Companies.

               All Contracts listed in Schedule 4.14(a) (except for those
               entered into by Group Companies located in France or in the
               United States of America), (i) in case of fixed term
               Contracts, do not exceed two (2) years in duration, (ii) in
               case of indefinite term Contracts, may be terminated with no
               more than six (6) months of prior notice and (iii) in all
               cases, with respect to Contracts involving payments by the
               Group Companies, do not represent, individually, post Closing
               Date commitments in excess of US$ 250,000 per year.

           (b) Except as set forth in Schedule 4.14(b), all Contracts listed
               in Schedule 4.14(a) to which a Group Company is a party are
               valid, binding and enforceable by one or more of the Group
               Companies in accordance with their respective terms and
               are in full force and effect, and none of the Group Companies
               is in default in any material respect under any of such
               Contracts.  To the best of Sanofi's knowledge, no other party
               to any of such Contracts is in default in any material respect
               thereunder.  To the best of Sanofi's knowledge, no event has
               occurred which, with the passage of time or the giving of
               notice or both would constitute a default by the Group
               Companies under any such Contracts.

           (c) Except as set forth in Schedule 4.14(c), the sale of the
               Shares to the Purchaser shall not entitle, pursuant to
               any express provision of any Contract listed in Schedule
               4.14(a), any other party to such Contracts to request that
               they be terminated, modified or renegotiated, as a result
               of such sale and, to the best of Sanofi's knowledge, as of
               the date hereof, the Group Companies have not received notice
               from any party to such Contracts to the effect that such
               party has decided to cancel or terminate any such Contract
               or exercise any option under any such Contract as a result of
               the sale of the Shares.

    <PAGE>
                                                                   20.

           (d) The Group Companies have ordered at least U.S.$ five (5)
               million of reagents and instrumentation applicable to
               the 1999 commitment under the April 30, 1997 Exclusive Dealer
               Agreement entered into between the Company and Beckman Coulter,
               Inc.  By December 31, 1999, the Group Companies will have met
               their 1999 commitment under such agreement.

           (e) Cumulatively, reagent rental agreements entered into by the
               Group Companies are enforceable and have been generally
               enforced by the Group Companies so as to maintain
               profitability at historical levels.

    4.15   Relations with the Sellers

    Except as otherwise stated in Schedule 4.15, neither the Sellers,
    nor any Affiliate of the Sellers (other than a Group Company), in all
    cases either directly or indirectly:

           (a) holds any property or rights whatsoever, which are necessary
               for the Group Companies to carry out their activities
               (other than the IP Patents and Trademarks and the Sanofi
               IVD Patents);

           (b) is party to any Contracts with any Group Companies nor has
               any rights against the Group Companies (other than the
               shareholders' rights of the Sellers vis-a-vis the Group
               Companies, Sanofi's rights to the Sanofi IVD Patents and IP's
               rights under the Cooperation Agreement and the licenses of the
               IP Patents and Trademarks to the Group Companies); or

           (c) has granted any guarantees or other security interests
               to secure any of the Group Companies' undertakings, or
               is the beneficiary of any guarantee granted by any of the
               Group Companies to secure any of their obligations vis-a-vis
               third parties.

    4.16   Disputes

    Except as set forth in Schedules 4.10.1(e), 4.10.2(g), 4.12(c), 4.13(b),
    4.16 and 4.20(e), there are no judicial, administrative or arbitration
    proceedings pending against any of the Group Companies, which, if
    determined adversely with respect to the relevant Group Company, would
    have a material adverse effect on its business condition or the economic
    or financial prospects of the Group Companies taken as a whole.  Except
    as set forth in Schedule 4.16, none of the Group Companies is a
    plaintiff in any litigation or proceeding where material counterclaims
    have been asserted against a Group Company.

    4.17   Compliance with Law

           (a) Except as indicated in Schedule 4.17, (i) the Group Companies
               possess all permits, certifications and other consents from
               governmental or other authorities required to conduct their
               respective operations as currently being conducted and (ii)
               the Group Companies are currently conducting their respective
               businesses in material compliance with these permits and
               consents and with all laws, ordinances and regulations which
               are currently applicable to them (except for instances of non-
               compliance that would not reasonably be expected to have a
               material adverse effect on the relevant Group Company),
               including but not limited to national, state, local and
               foreign environmental, work place safety and employee
               benefits laws and regulation.

           (b) No proceedings of any nature whatsoever have been undertaken
               which may result in the withdrawal, suspension or modification
               of any of the consents and permits held by the Group

    <PAGE>
                                                                   21.

               Companies and required to conduct the Group Companies'
               operations as currently  being conducted.  Except as set forth
               in Schedule 4.17(b), all such permits, certifications and
               consents are valid and in full force and effect and will not
               be terminated as a result of the sale of the Shares.

           (c) Except as set forth in Schedule 4.17(c), none of the Group
               Companies has received any notice from governmental or
               other authorities alleging any violation of any laws,
               ordinances or regulations currently pending, which, if
               determined against the relevant Group Company, would have
               a material adverse effect on its business condition or the
               economic or financial prospects of the Group Companies taken
               as a whole.

    4.18   Environment

    Except as indicated in Schedule  4.18, the Group Companies carry out
    their activities in compliance in all material respects with
    environmental laws and regulations currently applicable to them.
    In particular, the Group Companies have obtained all environmental
    authorizations and licenses required for the conduct of their operations
    as currently conducted, and the Group Companies comply in all
    material respects with said authorizations and licenses.  There
    have been no releases of hazardous substances (substances
    dangereuses pour l'environnement) within the meaning of classes
    no. 1170, 1171, 1172 and 1173 of the French decree of May 20,
    1953 relating to installations classees from or on the premises
    at which the Group Companies operate their business.  Except as
    indicated in Schedule 4.18, the Group Companies have not
    received notice of potential liability, under applicable
    environment laws and regulations, with respect to any sites and
    the Group Companies are not aware of any present events, facts,
    conditions or circumstances which violate environmental laws in
    any material respect or which currently form the basis of an
    environmental claim arising out of the release of such hazardous
    substances with respect to any of the sites in which they
    conduct their activities.

    4.19   Ancillary Assets

           (a) Except as set forth in Schedule 4.19(a) and except for
               the transfer to the Purchaser (or its designee(s)) of
               local product sanitary registration in respect of products sold
               through the Ancillary Assets, the Ancillary Assets are wholly-
               owned by the Ancillary Asset Sellers free and clear of all
               Liens except for Permitted Encumbrances, and there exists no
               restriction on the transfer of the Ancillary Assets.

           (b) All of the Ancillary Assets are in a state of good maintenance
               and repair and are usable for their intended purpose.

    4.20   Labor Matters

           (a) Schedule 4.20(a) is a list of employees (representing
               approximately 90% of the headcount) of the Group
               Companies (including, by way of exception to Section 4.12(a),
               the US Subsidiaries) and of the Ancillary Asset Employees,
               indicating the current rate of compensation for each such
               employee as of May 31, 1999.  The representation contained in
               this paragraph 4.20(a) with respect to employees of Group
               Companies other than those located in France, in the United
               States and in Brazil is made for information purposes only and
               may not result in indemnification of the Purchaser pursuant to
               Article 8 hereof.

           (b) Except as set forth in Schedule 4.20(b), the Group Companies
               do not participate in or contribute to any retirement plans,
               profit-sharing schemes or other optional employee incentive
               plans other than those required by applicable laws,
               regulations and/or collective bargaining agreements.  As

    <PAGE>
                                                                   22.

               of the date hereof, the Group Companies have made all required
               contributions payable under their respective plans and under
               the applicable social security regime.

           (c) Except as set forth in Schedule 4.20(c), none of the Group
               Companies has concluded any Contracts with any of its
               employees which provide, in the event of termination, for a
               notice period or payment of an indemnity which exceeds those
               provided for by applicable laws, regulations and/or collective
               bargaining agreements.

           (d) Schedule 4.20(d) sets forth all commitments and undertakings,
               outstanding as of the date hereof, made by the Group
               Companies (including, by way of exception to Section
               4.12(a), the US Subsidiaries) vis-a-vis their former
               employees.

           (e) Except as set forth in Schedule 4.20(e), none of the Group
               Companies has (i) given any undertakings or made any
               commitments in connection with any restructuring plan (plan
               social) that have not been entirely performed or fulfilled or
               (ii) given any undertakings or made any commitments in
               connection with a collective dismissal plan (licenciement
               collectif).

           (f) Except as set forth in Schedule 4.20(f), there is no current
               labor litigation involving claims by employees of the
               Group Companies.  No collective labor disputes, strikes, work
               stoppages or other interruption in service or performance due
               to collective labor disputes have occurred over the last three
               (3) years; and since then, all relationships between the Group
               Companies and its employees are generally stable and
               satisfactory.

           (g) Schedule 4.20(g) describes the particular undertakings
               given by the Group Companies (including, by way of
               exception to Section 4.12(a), the US Subsidiaries) to their
               employees in connection with the transactions contemplated by
               this Agreement.

           (h) Except as set forth in Schedule 4.20(h), the representations
               provided by paragraphs (a), (b), (c), (e), (f) and (g)
               of this Section 4.20 apply to the Ancillary Assets Employees.

    4.21   Product Liability

           (a) Except as set forth in Schedule 4.21(a) and for customary
               and limited batch recalls (those related to the lack
               of robustness of the biological products or defects in
               workmanship and not to defects that would impair the
               reliability of a diagnosis and may cause a public health
               problem), none of the Group Companies has received any
               order from any administrative or judicial authority, or
               any request from any professional or consumer body, to
               recall any of its products, or to inform its customers
               of a defect in any of its products.

           (b) Except as set forth in Schedule 4.21(b), no warranties
               have been granted by any of the Group Companies with
               respect to its products sold or services rendered under the
               terms of which any of them would be liable beyond the limits
               and periods provided for by law and/or the general conditions
               of sale of the Group Companies, as applicable.  There are no
               outstanding warranty claims against the Group Companies by any
               of its customers with respect to the products sold or the
               services rendered by the Group Companies.

    <PAGE>
                                                                   23.

    4.22   Brokers

    All negotiations relating to this Agreement and the transactions
    contemplated hereby have been carried out without the intervention
    of any person acting on behalf of any of Sanofi or the Group Companies
    in such manner as to give rise to any valid claim against any of the
    Group Companies or Purchaser for any broker's or finder's fee or similar
    compensation in connection with the transactions contemplated.

    4.23   No material adverse change

    Except for the consequences of termination, if any, of
    Change of Control Contracts referred to in Section 5.2 hereof,
    between the date hereof and the Closing Date, there shall not
    have occurred any event effectively adversely affecting the
    financial condition of the Group Companies, taken as a whole, by
    more than Euro 39,058,686.

    4.24   Year 2000 Compliance

    As of the date hereof, the Group Companies have achieved and
    performed all the objectives and actions contemplated to be
    achieved and performed by them on or prior to the date hereof
    pursuant to the Y2K Plans attached as Schedule 4.24 hereto
    (except for instances of absence of achievement or performance
    which do not have a material adverse effect on the Group
    Companies).

    4.25   Euro Compliance

    As of the date hereof, the Group Companies have achieved and
    performed all the objectives and actions contemplated to be
    achieved and performed by them on or prior to the date hereof
    pursuant to the Euro compliance plans attached as Schedule 4.25
    hereto (except for instances of absence of achievement or
    performance which do not have a material adverse effect on the
    Group Companies).

    4.26   Maintenance of Business

    Neither of the ten major customers of the Group Companies,
    respectively in France and in the United States of America,
    nor the ten major suppliers of the Group Companies, respectively
    in France and in the United States, have notified any of the Group
    Companies within the six-month period immediately preceding the
    date hereof of their intent to cease doing business with any of
    such companies or to reduce substantially the amount of the business
    that such customer is currently doing with any of the Group Companies;
    without prejudice to termination, pursuant to their respective terms,
    of agreements entered into between such Companies and customers or
    suppliers (including Beckman Coulter, Inc.).

                                  ARTICLE 5
                           COVENANTS OF THE SELLERS

    5.1    Management of the Group Companies between the date hereof and
           the Closing Date

    Between the date hereof and the Closing Date, except as otherwise
    provided for herein or as may be expressly agreed to by the Purchaser,
    the Sellers shall cause:

    <PAGE>
                                                                   24.

           (a) each of the Group Companies to carry out its activities
               solely within the normal and ordinary course of
               business, including not permitting the sale, transfer or
               disposition of any of the assets of the Group Companies, not
               entering into any material contract or commitment, engaging in
               any transaction, extending credit or incurring any obligation
               with respect to the Group Companies, in each case, other than
               in the usual and ordinary course of business and in a manner
               consistent with past practice, and not making or instituting
               any usual or novel methods of purchase, sale, management,
               operation, or other business practice in the management of
               the Group Companies, not modifying the compensation or
               benefits payable or to become payable to employees or agents
               of the Group Companies;

           (b) the Company not to decide upon, or make, any distribution
               of profit or reserves;

           (c) each of the Group Companies not to be a party to any merger,
               contribution or spin off; not to make any change to its
               capital, or issue securities of any nature whatsoever or
               warrants;

           (d) the Group Companies not to make any modifications to the
               respective articles of incorporation or by-laws of any of
               Group Companies;

           (e) the Group Companies not to incur any new loan granted by
               parties other than their shareholders and their respective
               Affiliates (except as may be directed by the Purchaser in
               view of the Closing);

           (f) the Group Companies not to agree to take any of the actions
               set forth above;

           (g) each of the Group Companies to refrain from making any change
               in the accounting practices or procedures applied by the
               Group Companies;

           (h) each of the Group Companies not to enter into, issue or grant
               to any third party any agreements, arrangements, warrants,
               call options, convertible rights or other rights (vested
               or contingent) to acquire any capital stock of the Group
               Companies;

           (i) the Group Companies to inform the Purchaser of the occurrence
               of any event referred to in Section 4.23 above.

    5.2    Consents / HCV License

    Until the Closing Date, the Purchaser shall use reasonable efforts to
    assist the Sellers and/or the Company, and from and after the Closing
    Date the Sellers shall use reasonable efforts to assist the Purchaser
    and/or the Company, in obtaining, prior to or after the Closing Date,
    the undertaking of the counterparty(ies) to any of the Contracts listed
    in Schedule 5.2 (the "Change of Control Contracts") not to terminate
    such Contract in connection with, or as a result of, the change of
    control of the Company hereby contemplated (the "Change of Control").

    In addition to the foregoing, until the Closing Date, the Purchaser
    shall cooperate with the Company and the Sellers, and from and after
    the Closing Date, the Sellers shall cooperate with the Company and
    the Purchaser in securing the consent of Ortho Diagnostics Systems,
    Inc. and Chiron Corporation (the "O/C Parties") to the Change of
    Control pursuant to Section 13.5 of the HCV License Agreement dated
    November 22, 1993 between the Ortho/Chiron Parties and the Company
    (the "HCV License").  To that effect, the Company shall, promptly

    <PAGE>
                                                                   25.

    following the execution hereof, notify the O/C Parties of the
    Change of Control and attempt to secure the O/C Parties' consent
    thereto as soon as possible.  The Purchaser shall fully participate
    in these efforts, including (i) by providing written assurances to the
    O/C Parties that the Purchaser shall cause the Company to continue
    implementing the HCV License in accordance with its terms and its
    existing net economic effect on the O/C Parties and with the Company's
    past practice, and (ii) by the Company providing to the O/C Parties
    reasonable incentives as agreed with the Purchaser to secure the
    necessary consent such as a non-exclusive license to the HIV probes
    on terms comparable to existing HIV 2 licenses of the Group Companies.

    In the event that, the O/C Parties having failed to consent to the
    Change of Control and having terminated the HCV License pursuant to
    Section 13.5 thereof, whether before or after the Closing, (i) the
    O/C Parties should have initiated legal proceedings to enjoin the
    Company from exploiting the HCV License or (ii) the Group Companies'
    sales of HCV License products should have decreased by more than 10%
    (compared to the sales of the same six-month period of the immediately
    preceding year) within the six-month period following the O/C Parties'
    notice to the Company of the termination of the HCV License pursuant to
    Section 13.5 thereof (excluding, however, any loss of HCV business
    resulting from a change in the regulatory requirements or social
    security or private insurance reimbursement regimes), then, the Sellers
    shall, promptly upon notice by the Purchaser, pay to the Purchaser
    the amount of Euro 19,529,343 as provisional indemnity (the "Provisional
    Indemnity") for the Loss suffered by the Company as a result of
    the O/C Parties' termination.

    In the circumstances described in the foregoing paragraph, the Purchaser
    shall cooperate with the Sellers and the Company in pursuing legal
    action against the O/C Parties for wrongful termination of the HCV
    License and in seeking reinstatement thereof as well as recovery of any
    damages suffered by the Company and the Sellers as a result of such
    termination.  If the dispute with the O/C Parties is finally
    resolved within twelve (12) months from the Closing Date, the
    Purchaser shall refund the Sellers with any fraction of the
    Provisional Indemnity equal to the excess of such indemnity over
    the Loss suffered by the Company as a result of the O/C Parties'
    termination of the HCV License, and the Sellers shall conversely
    indemnify the Purchaser of any excess of such effective Loss
    over the Provisional Indemnity up to an additional Euro 9,764,671.
    In the event that the dispute with the O/C Parties should not be
    finally resolved within twelve (12) months from the Closing
    Date, (A) the Purchaser shall be entitled to retain the
    Provisional Indemnity, subject to the Company's assignment to
    the Sellers of all of the Company's rights under the HCV License
    to receive monetary compensation from the O/C Parties for wrongful
    termination of the HCV License, and subject to the Purchaser's
    undertaking to cooperate with the Sellers and to grant the Sellers
    unrestricted access to the relevant information necessary to
    document such Sellers' monetary compensation demands, and (B)
    in addition, the Purchaser shall be entitled to claim additional
    damages from the Sellers up to a maximum amount of Euro 9,764,671
    in the event that the Purchaser can establish that the effective
    Loss suffered by the Group Companies as a result of the termination
    of the HCV License exceeds the Provisional Indemnity.

    Any indemnification of the Purchaser pursuant to this Section 5.2
    (including the payment of the Provisional Indemnity) shall be subject
    to the provisions of Article 8 hereof (including any limitations
    contained therein), provided, however, that the aggregate maximum
    amount of indemnification stipulated in Section 8.6(d) hereof shall
    be increased from Euro 39,058,686 to Euro 48,823,357 in the event
    that the HCV License is finally lost to the Company following
    the issuance of a final decision.

    <page<
                                                                   26.

    The Sellers shall assume the legal costs of the Company's
    involvement in any legal proceeding resulting from the
    O/C Parties' termination of the HCV License and shall have sole
    control over such proceedings and any settlement discussions and
    decisions in respect thereof.  Accordingly, the Purchaser shall
    not, and shall cause the Company not to, make any decision
    regarding any dispute with the O/C Parties arising out of the
    latter's refusal to consent to the Change of Control, without
    the prior written consent of the Sellers, which consent shall
    not be unreasonably withheld.

    5.3    Reasonable Access

    During the period from the date of this Agreement to the Closing,
    the Sellers shall, to the extent necessary, provide the Purchaser
    and its representatives (including the Purchaser's Auditor and
    counsel), upon at least two (2) Business Days' prior notice, with
    reasonable access to the books, financial reports prepared in the
    ordinary course of business, records, facilities, properties, assets,
    operations and authorized management of the Group Companies; provided
    that such access shall not interfere with the normal business
    operations of the relevant Entities and that the Purchaser and each
    of its representatives being provided such access undertake to keep the
    information thus communicated to them in strict confidence, upon
    terms substantially conforming to the terms of the Confidentiality
    Agreement.

    5.4    Services Agreements

    The services agreements entered into between IP and/or Sanofi
    and/or its Affiliates (other than the Group Companies), on the
    one hand, and the Group Companies, on the other hand, as listed
    in Schedule 5.4(a), shall automatically terminate on the Closing
    Date without indemnity to either party thereto.  The services
    agreements listed in Schedule 5.4(b) shall remain in effect
    pursuant to the financial terms thereof, as applicable during
    the first semester of 1999 for an initial six (6) month period
    following the Closing Date, renewable once; it being understood
    that the termination of said services agreements shall not give
    rise to any indemnity to either party thereto and the agreements
    listed in Schedule 5.4(c) shall remain effective pursuant to their
    respective terms.

    5.5    Termination of the Shareholders' Agreement  - Amendment to
           Cooperation Agreement

    Each of the Sellers hereby waives any and all rights that it may
    have pursuant to the Shareholders' Agreement in connection with
    or as a result of the consummation of the transactions contemplated
    hereby, in particular the rights of first refusal provided in
    Section 2.3.1 of the Shareholders Agreement.  Furthermore, IP
    hereby waives its veto right provided under Section 2.3.2 of the
    Shareholders Agreement, as well as its rights to rescind the
    Cooperation Agreement pursuant to Section 2.4.2 of the Shareholders'
    Agreement, in connection with or as a result of the consummation of
    the transactions contemplated hereby.

    Each of the Sellers hereby agrees that the Shareholders' Agreement
    shall automatically terminate upon the Closing and shall take all
    actions necessary to effect or formalize such termination.

    5.6    Transfer of Sanofi IVD Patents

    Sanofi undertakes to carry out any formalities required for the
    transfer of the registration of the Intellectual Property Rights
    currently registered under its own name or under the name of any
    of its Affiliates (other than the Group Companies) listed in

    <PAGE>
                                                                   27.

    Schedule 5.6 (the "Sanofi IVD Patents") in favor of the appropriate
    Group Companies, prior to or as soon as possible after the Closing
    Date; it being understood that Sanofi shall retain a non-exclusive
    prepaid license to use (with no right to sub-license or assign, except
    to an Affiliate) the Sanofi IVD Patents, in the field of
    therapeutics and toxic drugs monitoring, until their respective
    termination (the payment therefor being deemed included in the
    Purchase Price).  In the event that Sanofi decides to make
    effective use of such license in the field of toxic drugs
    monitoring, the Group Companies shall be offered by Sanofi an
    option to manufacture such tests for Sanofi, on competitive
    terms.

    5.7    Non compete

           (a) For a period of five (5) years following the Closing
               Date, the Sanofi Group shall not engage in the IVD
               Activities currently conducted by the Group Companies
               and on the territories currently covered by such activities
               (the "Business"), except as may be otherwise contemplated
               by this Agreement (including, without limitation, in
               connection with any subsequent transfers of Ancillary
               Assets and the Kyowa agreement referred to in Schedule
               4.19(a).  Nothing in this Section 5.7 shall, however,
               be construed as limiting the ability of the Sanofi Group
               to manufacture, use and sell products, technology and
               know-how currently developed, manufactured or distributed by
               the Group Companies, for purposes of testing its own
               pharmaceutical or other products or subsequent patient-
               monitoring related tests.

           (b) Notwithstanding the provisions of paragraph (b) above,
               the Sanofi Group shall be entitled to acquire control
               (within the meaning referred to in Article 355-1 of French law
               no. 66-537 of July 24, 1966 relating to commercial companies)
               of, or merge with, or otherwise enter into another business
               combination with, companies or groups of companies whose main
               activity does not consist of the Business, in whole or in
               part, provided that it shall not take any measure specifically
               designed to develop the Business during the above five-year
               period.

    5.8    Undertaking of IP

    For a period of three (3) years from the Closing Date, IP will abstain
    from engaging directly or indirectly (except through the licenses
    granted now or in the future) in the manufacturing, sale or distribution
    of IVD Products, representing sales in excess of US$ 10,000,000 per year;
    provided, however, that this undertaking shall not prevent IP from
    making initial investments in start-ups whose operations are based in
    whole or in part on intellectual property developed by IP.

    5.9    Specific Indemnification of Certain Disclosed Items

           (a) By way of exception to the provisions of Section 8.1(c)
               hereof, the Sellers shall indemnify the Purchaser for
               liabilities resulting from the following matters disclosed in
               the Schedules to this Agreement, under and subject to the
               following terms and conditions:

               (i) Scangel Proceedings:  In the event of the
                   delivery of an arbitral award adverse to the
                   Company in the proceeding described in
                   Schedule 4.10.1(e) hereto (involving
                   Diamed), the Sellers shall automatically pay
                   to the Purchaser an indemnity of Euro 4,882,336,
                   plus, as the case may be, the amount of any
                   effective Loss suffered by the Company (or the
                   Group Companies) in excess of such indemnity as
                   a result of such adverse award;

    <PAGE>
                                                                   28.


              (ii) Fujirebio / Centocor Matter:  In the event
                   of a final determination adverse to the
                   Company in the Fujirebio / Centocor matter
                   described in Schedule 4.14(b) hereto, the
                   Sellers shall automatically pay to the
                   Purchaser a lump sum indemnity in the amount
                   of Euro 2,929,401 (which amount will be final);

             (iii) Certain potential tax liabilities:  In the
                   event that the potential tax liabilities
                   described in Schedule 4.12(b) and in Exhibit
                   2(b) to Schedule 4.12(a) hereto should
                   materialize, the Sellers shall indemnify the
                   Purchaser for any effective Loss incurred by
                   the Company or the Group Companies in
                   connection therewith;

              (iv) Loss of Beckman Dealership Exclusivity:  In
                   the event that, within ninety (90) days of
                   having been notified to that effect by the
                   Company, Beckman Coulter, Inc. should
                   exercise its right to terminate the
                   exclusivity right of the Company under the
                   Exclusive Dealer Agreement dated April 30,
                   1997, on the basis of the Change of Control,
                   the Sellers shall pay to the Purchaser
                   automatically an indemnity of Euro 2,929,401,
                   plus, as the case may be, the amount of any
                   effective Loss suffered by the Company (or
                   the Group Companies) in excess of such
                   indemnity as a result of such termination;

               (v) Beckman Patent Indemnity:  The Sellers shall
                   indemnify the Purchaser, up to a maximum
                   amount of Euro 2 million, for the effective
                   Loss suffered by the Company or the Group
                   Companies as a result of the Company having
                   had to discharge the patent indemnity
                   described in Schedule 4.15(iii) hereto;

              (vi) Contaminated Blood Litigation:  Sanofi shall
                   indemnify and hold the Purchaser harmless
                   from any liability incurred by the Company
                   in connection with the HIV blood contamination
                   that occurred in France prior to 1986; provided,
                   however, that Sanofi is effectively subrogated in,
                   or otherwise assigned, all the rights of the Company
                   under its insurance policies and under any
                   other public or private indemnification scheme.
                   The Sellers shall also assume the legal costs of any
                   litigation imposed on the Company in connection with
                   this matter.  The Purchaser undertakes, at the request
                   of the Sellers, to cause the Company to involve the
                   relevant insurance companies in any such litigation.

           (b) All amounts payable by the Sellers under sub-paragraph
               (a) above shall be subject to the provisions of
               Article 8 of this Agreement (including any limitations
               contained therein), provided, however, that items (v) and
               (vi) above shall be indemnified irrespective of the aggregate
               maximum amount of indemnification stipulated in Section 8.6(d)
               hereof being reached.

    <PAGE>
                                                                   29.

                                      ARTICLE 6
                             COVENANTS OF THE PURCHASER

    6.1    Certain Guarantees and Repayments

           (a) The Purchaser undertakes to provide no later than on
               the Closing Date its guarantee or other credit support
               acceptable to the relevant creditors in replacement for all
               guarantees of Sanofi or its Affiliates (other than the Group
               Companies) extended in respect of any obligations of the Group
               Companies, a list of which is set forth in Schedule 4.15,
               except those guarantees referred to in Schedule 6.1(a).

           (b) The Purchaser undertakes to make available to the
               Group Companies from the Purchaser on the Closing Date
               sufficient lines of credit to permit them to repay, on the
               Closing Date, the total amount outstanding, including
               principal and interest, under any and all borrowings made by
               them from Sanofi or its Affiliates (other than the Group
               Companies), which amount (the "Preliminary Amount") shall
               be initially determined on the tenth (10) Business
               Day preceding the Closing Date and notified to the Purchaser
               no later than three (3) Business Days before the Closing Date.

               No later than five (5) Business Days following the
               Closing Date, Sanofi shall notify the Purchaser of the total
               amount effectively outstanding, including principal and
               interest, under any and all borrowings made by the Group
               Companies from Sanofi or its Affiliates (other than the Group
               Companies) as of the Closing Date (but prior to the Closing)
               (the "Closing Date Amount").  If the Closing Date Amount
               exceeds the Preliminary Amount, the Purchaser shall cause the
               Group Companies to reimburse to Sanofi or its relevant
               Affiliates the difference between these two Amounts no later
               than five (5) Business Days after receipt by the Purchaser of
               the notification of the Closing Date Amount.  If the Closing
               Date Amount is less than the Preliminary Amount, Sanofi agrees
               to pay, or cause to be paid to the relevant Group Companies,
               the difference between these two Amounts no later than five
               (5)  Business Days following receipt by the Purchaser of the
               notification of the Closing Date Amount.

    6.2    Employee Benefit Matters

           (a) The Purchaser shall cause the Group Companies to
               pay their employees the amounts due to them pursuant to the
               agreements attached as Schedule 6.2(a), with respect to the
               period running from January 1, 1999 to the Closing Date, as
               such amounts shall be calculated by Sanofi, in the exercise
               of its reasonable judgment, and notified to Purchaser; it is
               specified that the Group Companies have provided for adequate
               reserves, on a monthly basis, in respect of all sums due under
               such agreements.

           (b) Sanofi and its Affiliates shall remain liable,
               after the Closing Date, for certain benefit obligations of
               Sanofi (through its Affiliate, Sanofi, Inc.) to the employees
               of SDP, Inc. and Genetic Systems Corporation accrued in
               respect of the period ending on the Closing Date, in
               accordance with Schedule 6.2(b).  The Purchaser shall
               satisfy its obligations under Schedule 6.2(b).

           (c) The Purchaser shall, and shall cause the Group
               Companies located in France to, maintain for a period of
               eighteen (18) months after the Closing Date, without
               interruption, employee compensation and benefit plans,
               programs and policies and fringe benefits that are no
               less favorable than those in effect as of the Closing Date.
               To the extent permitted by applicable law, the employees of
               such Group Companies shall continue to be given credit after
               the Closing Date for all service credited to them prior to
               the Closing Date, for purposes of eligibility, vesting,

    <PAGE>
                                                                   30.

               benefit accrual, seniority or otherwise, under all employee
               compensation and benefit plans, programs and policies and
               fringe benefits then in effect.  The Purchaser shall, and
               shall cause such Group Companies to, grant to any employees
               of such Group Companies dismissed within a period of eighteen
               (18) months after the Closing Date severance terms consistent
               with such Group Companies' past practices as implemented
               prior to December 31, 1998.

    6.3    Use of the "Sanofi" Name

    No later than the earlier of the expiration of a period of eighteen (18)
    months following the Closing Date and the date on which substantially all
    stocks of products bearing the name "Sanofi", as in existence as of the
    date hereof, are sold or destroyed, the Purchaser undertakes (i) to cause
    any use of the "Sanofi" name by the Group Companies or the Ancillary
    Assets to definitively cease and (ii) to destroy or re-label, upon
    request from Sanofi or the relevant Ancillary Assets Sellers, any
    product or object on which the name "Sanofi" appears (with written
    confirmation of destruction or re-labeling to Sanofi).

    The eighteen (18) months limitation provided in this Section 6.3
    shall not apply to the reagent rentals having a residual term as of
    the Closing Date greater than one (1) year, in respect of which the
    Purchaser shall cause the Group Companies to use their reasonable
    efforts to remove the "Sanofi" name affixed thereto as soon as possible.

    The Purchaser shall cause the corporate names of the Group Companies
    which include the "Sanofi" name to be modified no later than three (3)
    months after the Closing Date, to remove the name Sanofi therefrom.

    The Purchaser shall indemnify and hold Sanofi harmless from and against
    any and all liabilities that may result from the use of the "Sanofi"
    name following the Closing Date (including as contemplated by this
    Section 6.3).

    6.4    Guarantees of the Sellers not released at Closing

    In the event that a claim involving a Group Company and/or Sanofi,
    in respect of matters for which Sanofi is a guarantor of any Group
    Company(ies) (as indicated in Schedule 6.1(a)) or may otherwise be
    held liable, is made prior to or after the Closing Date and is not
    finally settled before the Closing Date, Sanofi may retain counsel
    at its own expense to defend the interests of the Group Company
    involved.  At Sanofi's request, the Purchaser shall cause the relevant
    Group Company, as the case may be, to present all arguments, submit all
    pleadings, take all actions, file all counterclaims and more
    generally cooperate with Sanofi and the counsel appointed by it.
    The Purchaser shall provide, and shall cause the Group Companies
    to provide Sanofi with all information or documents in relation
    to said claim that Sanofi may reasonably request and generally,
    to fully cooperate.  The Purchaser shall not, and shall cause
    the Group Companies not to, settle, admit liability or withdraw
    any claim (including oppositions in relation to intellectual
    property rights) in connection with said claim without the prior
    written consent of Sanofi.

    6.5    US GAAP Financial Statements

    The Purchaser shall cause the Purchaser's Auditor to take any and
    all actions necessary to satisfy the condition set forth in
    paragraph 10.1(b)(iii) as soon as possible following the date
    hereof so as to enable the Closing to take place on August 31, 1999.

    <PAGE>
                                                                   31.

    The Sellers shall cause the Group Companies and the Sellers'
    Auditor to cooperate with the Purchaser's Auditor in connection
    with the preparation of the financial statements referred to in
    such paragraph.

                              ARTICLE 7
                          ANCILLARY ASSETS

    7.1    The Ancillary Assets referred to in Exhibit C shall be
    transferred to the Purchaser (and the Purchaser shall assume the
    employment contracts of the persons employed principally in the
    conduct of the IVD Activities, which persons are listed in
    Schedule 7.1 (the "Ancillary Asset Employees") in accordance
    with the principles set forth in this Section.  To that effect,
    the Purchaser and Sanofi shall determine, prior to the Closing
    Date, the detailed list of the Ancillary Assets, as well as the
    related liabilities and contracts.

    7.2    The Purchaser and Sanofi shall cooperate in order to
    find a mutually acceptable solution in order to ensure that the
    transfers of the Ancillary Assets contemplated hereby maximizes
    the economic and tax benefits for both Parties; failing an
    agreement between the Parties in this respect, the transfer of
    the Ancillary Assets concerned shall be effected by way of a
    transfer of assets.

    7.3    (a) The Ancillary Assets shall be transferred to the
               Purchaser (or its designee(s)) on the Closing Date,
               or on such subsequent date as the parties shall mutually
               determine allowing completion of the reorganizations
               referred to in Section 7.3(b)) and/or regulatory approvals
               be obtained, and the assumption by the Purchaser (or its
               designee(s)) of the employment contracts of the Ancillary
               Assets Employees will occur simultaneously.

           (b) The transfer to the Purchaser (or its designee(s)) of the
               Ancillary Assets listed in Schedule 7.3(b) shall be effected
               following their reorganization, as described in such Schedule.

    7.4    From the date hereof to the date on which the relevant
    Ancillary Assets shall be transferred to the Purchaser (or its
    designee(s)), Sanofi shall cause the Ancillary Asset Sellers,
    except for purposes of the reorganizations described in Schedule
    7.3(b), (i) to manage the Ancillary Assets solely in accordance
    with past practice and in the normal and ordinary course of
    business (ii) not to enter into any contribution agreement with
    respect to the Ancillary Assets, (iii) not to make any material
    change in the accounting practices in connection with the
    Ancillary Assets and (iv) not to modify the employment status of
    any of the Ancillary Asset Employees, or any employment policies
    applicable to them, or to grant to any of them any increase or
    modification of compensation or benefits other than any such
    increases or modifications required by applicable law or the
    applicable collective employment conditions.

    7.5    If, as a result of the aforementioned reorganizations,
    certain Ancillary Assets may be transferred to or otherwise
    isolated within Entities whose shares are to be acquired by the
    Purchaser (or its designee(s)):

          (i) the Purchaser undertakes to provide or cause to
              provide, no later than on the date of transfer
              of such Entities, its guarantee or other credit
              support acceptable to the relevant creditors in
              replacement for any and all guarantees of Sanofi
              or its Affiliates (other than the Group
              Companies) extended in respect of any
              obligations of such Entities which will
              terminate on the Closing Date;

    <PAGE>
                                                                   32.


         (ii) the Purchaser undertakes to make available or
              have made available to such Entities, on the
              date of transfer thereof, sufficient lines of
              credit to permit them to repay, on such date,
              the total amount outstanding, including
              principal and interest, on any and all
              borrowings made by them from Sanofi and/or its
              Affiliates other than the Group Companies,
              according to the provisions set forth in Section
              6.1(b); and

        (iii) the services agreements entered into between
              Sanofi and its Affiliates other than the Group
              Companies, on the one hand, and such Entities,
              on the other hand, if then in effect, shall
              automatically terminate on the date of transfer
              of said Ancillary Assets without giving rise to
              any indemnity whatsoever to either of the
              parties thereto, except as may be agreed between
              the Parties, unless Sanofi and the Purchaser
              agree to enter into a transition services
              agreement, upon terms and conditions mutually
              agreeable to them, to maintain the continuity of
              service for a limited period of time, without
              prejudice to the provisions of Section 5.4.

                             ARTICLE 8
                           NDEMNIFICATION

    8.1    Principle

           (a) Each Seller hereby undertakes to indemnify the
               Purchaser for damages, losses and reasonable expenses
               (including reasonable attorneys' fees) (collectively a
               "Loss") suffered by the Purchaser or the Group Companies
               as a result of:

               (i) any inaccuracy or breach of any representation or warranty
                   extended by such Seller contained in this Agreement; or

              (ii) any breach of any covenant or undertaking of such Seller
                   contained in this Agreement.

               Any Loss resulting from an inaccuracy or breach of a
               representation or warranty extended by both Sellers shall be
               indemnified by each of them prorata to its shareholding in
               the Company.

           (b) Certain additional indemnification and Tax matters relating
               to U.S. Subsidiaries are set forth in Schedule 8.1(b).

           (c) It is specified that the Sellers shall not indemnify the
               Purchaser in respect of any facts or matters which were
               disclosed in this Agreement (including in any Exhibits or
               Schedules thereto or in any document specifically referred to
               therein) except as specifically provided in Sections 5.2 and
               5.9 hereof.  Any disclosure made in a schedule relating to a
               given representation provided by this Agreement shall only be
               made against such representation; provided, however, that
               disclosures contained in Schedules 4.10, 4.16 and 4.20 shall
               be deemed made against all the representations and warranties
               of the Sellers contained in this Agreement and, provided
               further, that the Purchaser shall not be entitled to
               indemnification hereunder on the basis of a claim of
               non-disclosure of a fact specifically disclosed by the Sellers
               in any of the Exhibits and Schedules to this Agreement.

    <PAGE>
                                                                   33.

    8.2    Claims

    In order to be valid, any claims made by the Purchaser under the terms
    of this Article 8 and/or Sections 5.2 and 5.9 hereof (a "Claim") shall
    be made in writing as follows:

           (a) each Claim shall state, with reasonable detail,
               the specific grounds therefor and the amount claimed;

           (b) each Claim shall be made with reasonable promptness after
               the Purchaser becomes aware of the circumstances giving
               rise thereto (and in any event prior to the expiration of
               a statutory deadline); provided, however, that any
               failure to give a timely notice will not waive any rights
               of the Purchaser except to the extent that the rights of
               the relevant Seller are actually prejudiced by any such delay.

    8.3    Deadlines for Claims

    Any Claims may give rise to indemnification only if notified by
    the Purchaser to the relevant Seller prior to the expiration of a
    three (3) year period from the Closing Date, or, for Claims related
    to Tax and environmental matters, as well as the contaminated blood
    litigation referred to in Section 5.9, prior to the expiration of a
    one-month period following the date of expiration of the relevant
    statute of limitations.

    8.4    Third-Party Claims

    In the event that a claim is made by a third party against a Group
    Company which constitutes or may become the basis for a Claim, the
    relevant Seller may retain counsel at its own expense to defend the
    interests of the Group Company involved.  At such Seller's request,
    the Purchaser shall cause said Group Company, as the case may be, to
    present all arguments, submit all pleadings, take all actions, file all
    counterclaims and more generally cooperate with the relevant Seller
    and the counsel appointed by it.  The Purchaser shall provide, and
    shall cause the Group Companies to provide the relevant Seller with
    all information or documents in relation to said third-party claim that
    the relevant Seller may reasonably request.  The Purchaser shall not,
    and shall cause the Group Companies not to, settle, admit liability or
    withdraw any claim in connection with said third-party claim without
    the prior written consent of the relevant Seller, not to be unreasonably
    withheld.

    8.5    Effective Nature of the Loss

           (a) Any deficiency assessed by the Tax authorities whose sole
               effect is to shift a tax liability from one fiscal
               year to another shall give rise to indemnification by the
               relevant Seller only insofar as a Group Company is required to
               pay a penalty or interest charge in relation thereto.

           (b) Any deficiency assessed with regard to a Tax, such as a
               value-added tax, which is recoverable shall give rise
               to indemnification by the relevant Seller only insofar as a
               Group Company is required to pay a penalty or interest charge
               in relation thereto.

           (c) For purposes of calculation of the indemnification due
               by any Seller, any amounts paid to the Purchaser, the Group
               Companies under insurance policies or any other amount
               compensating the Loss for which the Claim is made shall be
               deducted or reimbursed to such Seller, as the case may be.
               If the relevant Seller pays an indemnity in respect of a
               Loss and the Purchaser or any of the Group Companies
               subsequently recovers (even after expiration of the relevant

    <PAGE>
                                                                   34.

               time limit set forth in Section 8.3) all or part of the amount
               of such indemnity from a third party (including insurance
               companies or tax authorities), the Purchaser shall take or
               shall cause the Group Companies to take all reasonable steps
               to recover such amount and, immediately upon recovery thereof,
               shall pay, or cause the Group Companies to pay, to the relevant
               Seller the amount thereby recovered (and in the event that such
               recovery shall result in the indemnification due in connection
               with the net amount of the concerned Loss falling below the
               amount specified in subsection 8.6(c) or in the total
               indemnification due in connection with the net amount of the
               concerned Loss and the other Losses, if any, which are eligible
               for indemnification by the Sellers, falling below the amount
               specified in subsection 8.6(b), the Purchaser shall repay to
               the relevant Seller the full amount paid by it in respect of
               all relevant Loss and/or Losses).

           (d) Any indemnification owed by any Seller shall be based on
               the amount of the Loss effectively suffered by the
               Group Companies, and shall be computed without regard to any
               multiple, price-earnings or equivalent ratio implicit in
               negotiating and/or setting the Share Purchase Price, except
               as expressly provided in Section 4.7(c).

           (e) Except as otherwise provided in Section 5.2 or 5.9 hereof,
               in the event that a Group Company is required to make a
               payment in connection with a third-party claim, the relevant
               Seller shall not be required to make any indemnification
               payment in connection thereto before such payment has actually
               been made by such Group Company to such third party.

           (f) Any item which, in the course of the procedure provided in
               Section 2.1.3(b), either (x) will have been specifically
               taken into account for the purpose of the Share Purchase
               Price Adjustment or (y) will have been settled as a result
               of an agreement between the Parties (or their respective
               Auditors) or a decision of the Independent Auditor, shall be
               excluded from indemnification by the Sellers.

    8.6    Determination of the Indemnification

           (a) The amount of the indemnity to the Purchaser due by any
               Seller in connection with a Loss sustained by a Group
               Company shall be pro-rated for the direct and/or indirect
               interest held by the Purchaser in the share capital of said
               Group Company as of the Closing Date.

           (b) No indemnification shall be due by any Seller unless the
               aggregate amount of the indemnification owed by the
               Sellers (but for this subsection (b)) exceeds (after all
               deductions pursuant to this Article 8) six million
               (6,000,000) French Francs, and such indemnification shall
               then become due only for the portion exceeding such amount.

           (c) In respect of individual Claims, the Purchaser shall not
               be entitled to indemnification unless the amount of
               the indemnification exceeds one hundred thousand (100,000)
               French francs per such individual Claim.

           (d) The total indemnification that may be due by the Sellers
               to the Purchaser under this Agreement shall not exceed
               in the aggregate thirty-nine million fifty-eight thousand six
               hundred and eighty-six (39,058,686) Euros.  As the sole two
               exceptions to the foregoing stipulation, the limitation
               provided for in this paragraph 8.6(d) shall not apply to
               (i) indemnification arising out of inaccuracies of or omissions
               in respect of the representations of this Agreement relating
               to taxes (Section 4.12) and the environment (Section 4.18)
               and (ii) indemnification for any damages that may be incurred
               by PSD as a result of any potential liability in connection
               with the "contaminated blood" litigation (as set forth in
               Schedule 4.16 hereof).

    <PAGE>
                                                                   35.

    8.7    Exonerating and Mitigating Factors

           (a) The Sellers shall not be held liable for indemnification
               to the extent the Loss for which indemnification is
               sought may be attributed to any voluntary action or voluntary
               omission on the part of the Purchaser or the Group Companies
               after the Closing Date or to any change in accounting methods
               (including consolidation methods) or policies of the Group
               Companies after such date.

           (b) The Sellers shall not be held liable in respect of any breach
               of a representation or warranty which would not have occurred
               but for any Tax related law passed after the date hereof with
               retroactive effect and any other law passed after the date
               hereof.

           (c) The Sellers shall not be held liable for indemnification
               to the extent the Purchaser and the Group Companies did not,
               upon learning of the situation giving rise or likely to give
               rise to a Loss, use, or as concerns the Purchaser, caused the
               Group Companies to use, reasonable efforts to mitigate the
               corresponding Loss, subject to the corporate interest of the
               Group Companies.

           (d) In the event that a situation giving rise to a Claim is
               curable, in whole or in part, the Purchaser shall give
               the relevant Seller a reasonable opportunity to implement
               such a cure for a period of thirty (30) days from notice
               thereof, provided that such opportunity for cure shall not
               increase the original damage or materially impair the
               operations of the Purchaser.

           (e) Any indemnification due by any Seller in connection with
               any Loss resulting from matters specifically reserved against
               by the Group Companies (whether in a general reserve account
               or in a specific reserve account) shall be reduced by the
               amount of such reserves.

    8.8    Exclusivity of Remedy

    Except in the case of fraud committed by the Sellers, the indemnification
    provided in this Article 8 shall be the sole and exclusive remedy of the
    Purchaser against the Sellers in respect of any breach of any
    representation, warranty, covenant or undertaking of the Sellers and the
    Purchaser hereby waives any rights to rescission it may have.

    8.9    No Other Representations

    The Sellers do not make any representation or give any warranty to the
    Purchaser other than as specifically provided for in Article 4 and
    Schedule 4.12(a).  Without limiting the generality of the foregoing,
    the Sellers do not make any representation or give any warranty to the
    Purchaser with respect to financial projections, budgets or management
    analyses relating to any of the Group Companies and to the future
    profitability and financial performance of any of the Group Companies.

                              ARTICLE 9
                               CLOSING

    9.1    Date and Place of Closing

    The closing of the sale and purchase of the Shares and the Ancillary
    Assets shall take place as follows:

    <PAGE>
                                                                   36.

         (i) the principal closing (the "Closing") shall take place at the
             offices of Cleary, Gottlieb, Steen & Hamilton, 41, avenue de
             Friedland, 75008 Paris, on August 31, 1999 or, if all conditions
             precedent set forth in Section 10.1 have not been fulfilled or
             waived in accordance herewith prior to such date, on
             September 30, 1999 or any such other date as may be mutually
             agreed by the Parties.  The date of the Closing is herein
             referred to as the "Closing Date";

        (ii) subsequent closings may take place to consummate the purchase
             and sale of those Ancillary Assets (x) which involve
             reorganizations prior to their transfer to the Purchaser
             (or its designee(s)) as set forth in Section 7.3(b) and were
             not so purchased and sold at the Closing or (y) in respect of
             which transfer all required regulatory approvals shall have
             not been obtained prior to the Closing Date; it being understood
             that the Parties agree to use their best efforts to cause such
             subsequent closings to take place within six (6) months after the
             Closing Date and on the last day of the month (and if such day
             is not a Business Day, on the next succeeding Business Day).

    9.2    Closing Transactions

           (a) On the Closing Date:

             (i) The Sellers shall transfer and deliver to the Purchaser:

                 (aa) all documents necessary to effect the transfer of
                      the ownership of the Shares (together with any
                      shares of the Company owned by any legal
                      representative of the Company that represents the
                      interests of the Sellers) to the Purchaser
                      including duly completed and signed transfer
                      orders;

                 (bb) all documents necessary to effect the transfer of
                      the ownership of any share of any Group Company
                      owned by the Sanofi Group or IP or any
                      shareholder of such Group Company that represents
                      the interests of the Sellers or their Affiliates.

                 (cc) unconditional resignation letters, effective on
                      the Closing Date, from all of the legal
                      representatives of the Group Companies that
                      represent the interests of the Sellers or their
                      Affiliates, including those members of their
                      boards of directors and supervisory boards that
                      represent the interests of the Sellers or its
                      Affiliates, with the exception of those persons
                      mentioned on a list that will be notified in
                      writing by the Purchaser to the Sellers no later
                      than fifteen (15) days prior to the Closing Date;

                 (dd) a certified copy of the minute of the meeting of
                      the board of directors of the Company approving
                      the Purchaser as shareholder of the Company;

                 (ee) a written status report of all third party
                      consents requested in connection with the Change
                      of Control Contracts;

                 (ff) letters of resignation, duly signed by the
                      statutory auditors and alternate statutory
                      auditors of each of the Group Companies, with
                      effect as of the next succeeding general meeting
                      of the shareholders of such companies; and

    <PAGE>
                                                                   37.

                 (gg) if the Closing Date is not August 31, 1999, any
                      updates and amendments to the Exhibits and
                      Schedules to this Agreement that the Parties
                      shall mutually agree are necessary or appropriate
                      to maintain the accuracy of the statements
                      contained in Article 4 as of the Closing Date, it
                      being understood that the consent of the
                      Purchaser shall not be unreasonably withheld.

            (ii) The Ancillary Asset Sellers shall deliver to the
                 Purchaser (or its designee(s)) all documents
                 necessary to effect the transfer to the Purchaser
                 (or its designee(s)) of all Ancillary Assets to
                 be so transferred on the Closing Date.

           (iii) The Purchaser shall pay the Share Purchase Price
                 and the Ancillary Asset Purchase Price of any
                 Ancillary Assets transferred on the Closing Date
                 in accordance with Article 2 and shall cause the
                 Group Companies to pay, in immediately available
                 funds, the Preliminary Amount referred to in
                 Section 6.1(b).

            (iv) The Purchaser shall deliver to the Sellers:

                 (aa) written waivers from the relevant creditors for
                      all guarantees that the Sellers or their
                      Affiliates other than the Group Companies made in
                      respect of any obligations of the Group
                      Companies, a list of which guarantees is set
                      forth in Schedule 4.15(iii) except those
                      guarantees referred to in Schedule 6.1(a); and

                 (bb) written evidence that any regulatory approval of
                      the transaction contemplated hereby as may be
                      required has been obtained.

           (b) On each subsequent date on which Ancillary Assets
               may be transferred, the relevant Ancillary Asset Sellers shall
               deliver to the Purchaser (or its designee(s)) all documents
               necessary to effect the transfer to the Purchaser (or its
               designee(s)) of all Ancillary Assets to be so transferred on
               such date and the Purchaser shall pay the Ancillary Asset
               Purchase Price of any Ancillary Assets transferred on such
               date in accordance with Section 2.2.2.

                                       ARTICLE 10
                           CONDITIONS PRECEDENT - TERMINATION

    10.1   Conditions Precedent

    The completion of the sale of the Shares and the Ancillary Assets
    is subject to the fulfillment of the following conditions precedent,
    it being specified that, in the event that certain of the regulatory
    approvals referred to in paragraph 10.1(a)(ii) below that are
    necessary for the transfer to the Purchaser of certain Ancillary
    Assets shall not have been obtained prior to the Closing Date, the
    absence of such approvals shall not affect the date of transfer of
    the Shares and shall only result in the postponement of the date of
    transfer to the Purchaser of the Ancillary Assets concerned as
    contemplated by Paragraph 9.1 (ii) hereof:

           (a) For the benefit of each of the Purchaser and the Sellers:

    <PAGE>
                                                                   38.

             (i) no injunction from a court of competent
                 jurisdiction shall have been issued to enjoin the
                 completion of the transactions contemplated by
                 this Agreement;

            (ii) any regulatory approval required to be obtained
                 by the Sellers or the Purchaser prior to the
                 consummation of the transaction contemplated
                 hereby and necessary to consummate such
                 transaction shall have been obtained; and

           (iii) the board of directors of the Company shall have
                 approved the Purchaser as shareholder of the
                 Company.

           (b) For the exclusive benefit of the Purchaser, it
               being understood that these conditions may be waived, in
               whole or in part, at any time prior to the Closing Date,
               in writing by the Purchaser:

             (i) except for the consequences of termination, if
                 any, of material Contracts referred to in Section
                 5.2 hereof, between the date hereof and the
                 Closing Date, there shall not have occurred any
                 event effectively adversely affecting the
                 financial condition of the Group Companies, taken
                 as a whole, by more than Euro 39,058,686;

            (ii) the Sellers shall not be in breach of any
                 material covenant or agreement by them set forth
                 herein; and

           (iii) the Purchaser's Auditor shall have prepared and
                 delivered an audit report and audited
                 consolidated financial statements in US dollars
                 according to U.S. Generally Accepted Accounting
                 Principles for the Group Companies in respect of
                 fiscal years 1996, 1997 and 1998 prepared by the
                 Group Companies, all meeting the requirements of
                 Regulation S-X under the Securities Act of 1933,
                 as amended, applicable to Registration Statement
                 under such Act on Form S-1 and also meeting
                 requirements for SEC Form 8-K.

           (c) For the exclusive benefit of the Sellers, it
               being understood that this condition may be waived at
               any time prior to the Closing Date in writing by the
               Sellers:

             (i) all of the representations of the Purchaser set
                 forth in Article 3 shall be true and accurate as
                 if made as of the Closing Date; and

            (ii) the Purchaser shall not be in breach of any
                 covenant or agreement by it set forth herein, in
                 particular, the Purchaser shall have complied
                 with the obligations provided by Section 6.1 (a)
                 and (b).

    The Parties undertake to use their best efforts to fulfill all
    the conditions precedent set forth in Section 10.1 above (and
    in particular to obtain the required approvals to the contemplated
    transaction) as soon as possible.

    10.2   Termination

    In the event that the conditions precedent set forth above in
    Section 10.1 are not fulfilled (or, as concerns the
    conditions set forth in Section 10.1(b) and (c), are not waived

    <PAGE>
                                                                   39.

    by their respective beneficiaries) at the latest on October 31,
    1999, this Agreement shall automatically terminate without
    prejudice to (i) the rights of any Party in the event of a prior
    breach hereof by another Party and (ii) the provisions of the
    confidentiality agreement entered into by the Purchaser on March
    5, 1999 (the "Confidentiality Agreement") which will survive
    the termination of this Agreement.

                              ARTICLE 11
                          GENERAL PROVISIONS

    11.1   Cooperation

    Subject to the terms and conditions herein provided, each of
    the Parties hereto agrees to use its best efforts to take,
    or cause to be taken, all actions and to do, or cause to
    be done, all things necessary, proper or advisable under
    applicable law to consummate and make effective the transactions
    contemplated by this Agreement.  If at any time after the
    Closing any further action is necessary or desirable to carry
    out the purposes of this Agreement, the authorized officers or
    directors of the Sellers or Purchaser, as the case may be, shall
    take all such action.  The Sellers on the one hand and Purchaser
    on the other hand shall fully cooperate with each other with
    respect to any such further actions; to that effect, the Company
    shall provide to the Purchaser those monthly financial reports
    prepared by the Group Companies in the ordinary course of
    business.

    11.2   Confidentiality and Announcements

    The Parties hereby agree to keep confidential the terms and
    conditions contained in this Agreement, except as may
    be required by applicable law or requested by a competent
    judicial, administrative or regulatory authority, in which case
    the disclosure that may be required to be made by either Party
    shall be subject to the prior written consent of the other
    Party, which consent shall not be unreasonably withheld.

    Consequently, all announcements made in connection with this
    Agreement and the transactions contemplated hereby shall be
    the subject of a consultation between the Parties and a
    prior agreement between the Purchaser and the Sellers, which
    agreement shall not be unreasonably withheld.  Notwithstanding
    the foregoing, the Purchaser may disclose the terms and
    conditions of this Agreement and any information furnished by
    the Sellers in connection herewith to any person reasonably
    necessary to facilitate any proposed financing of the
    transactions contemplated herein, provided, however, that such
    person shall agree to protect the confidentiality of such terms,
    conditions and information.  Such disclosure shall be subject,
    in any event, to the prior review thereof and comments thereon
    by the Sellers to the extent that such disclosure may relate to
    them, which the Purchaser agrees to take into account to the
    greatest reasonable extent.

    11.3   Absence of Third-Party Rights - Assignment

    This Agreement is concluded for the sole benefit of
    the Parties (and their respective successors), and shall not
    benefit or create any rights whatsoever in favor of any third
    party.  This Agreement shall not be assigned by either Party
    without the prior written consent of the other, except to
    wholly-owned Affiliates of such Party, provided, however, that
    the assigning Party shall remain jointly liable with the
    assignee for all of its obligations and liabilities hereunder,
    for the entire term thereof.

    <PAGE>
                                                                   40.

    11.4   Entire Agreement

    This Agreement (including its Exhibits and its Schedules)
    represents the entire agreement existing between the
    Parties relating to the subject matter hereof and supersedes all
    prior understandings and agreements (other than the
    Confidentiality Agreement) of the Parties with respect to the
    subject matter hereof.  The Purchaser acknowledges that neither
    the Sellers nor any of their Affiliates, directors, employees,
    agents, representatives or advisors makes any representation or
    warranty, either express or implied, as to the accuracy or
    completeness of (and agrees that none of such persons shall have
    any liability or responsibility to it in respect of) any of the
    information provided or made available to the Purchaser or its
    agents or representatives, except as and only to the extent
    expressly provided for in this Agreement.

    11.5   Waivers and Amendments

    No modification of or amendment to this Agreement shall be valid
    unless set forth in an instrument in writing signed by each of
    the Parties.  Any waiver of any term or condition of this Agreement
    must be set forth in an instrument in writing signed by the waiving
    Party and must refer specifically to the term or condition to be
    waived and to the circumstances of such waiver.  No such waiver shall
    be deemed to constitute a waiver applicable either to other
    circumstances involving the same term or condition or to any other
    term or condition of this Agreement.

    11.6   Severability

    If any provision of this Agreement is held to be invalid in
    whole or in part, the validity of the remaining provisions
    of the Agreement shall not be affected.  In such event, the
    Parties shall, if possible, substitute for such invalid
    provision a valid provision corresponding to the spirit
    and purpose thereof.

    11.7   Section Headings

    The section headings in this Agreement are for
    convenience of reference only and shall not be deemed in
    themselves to have any contractual value or particular
    interpretation.  Except as indicated otherwise, references made
    in this Agreement to articles, sections, subsections, Exhibits
    and schedules are made to articles, sections, subsections,
    Exhibits and schedules of this Agreement.

    11.8   Representation

           (a) IP hereby gives to Sanofi all necessary powers, for
               the entire term and all consequences hereof, in order to be
               represented by Sanofi, for the purpose of all notifications
               or communications to be made to or by IP under the terms
               hereof or in connection herewith. The foregoing delegation
               is for administrative convenience only and shall, in no way
               affect the rights and obligations of IP.

           (b) Sanofi hereby represents that it has been given the necessary
               powers from the Ancillary Asset Sellers, for the entire term
               and all consequences hereof, in order to represent them
               vis-a-vis the Purchaser.  Consequently, all actions, claims,
               objections or decisions on the part of the Ancillary Asset
               Sellers provided for herein or in connection herewith shall
               be validly engaged, made or taken in their name by Sanofi.
               Likewise, the Ancillary Asset Sellers shall be validly
               represented by Sanofi for the purpose of all notifications or
               communications to be made to or by them under the terms hereof
               or in connection herewith.

    <PAGE>
                                                                   41.


    11.9    Notices and Communications

    All notices and communications provided for herein shall be deemed to
    have been duly given if delivered to the following addresses:

            - If to the Purchaser, to:

              Bio-Rad Laboratories Inc.
              1000 Alfred Nobel Drive
              Hercules, California, 94547
              To the attention of General Counsel

            - If to the Sellers, to:

              Sanofi
              174, avenue de France
              75013 Paris
              To the attention of General Counsel

              and:

              Institut Pasteur
              25-28, rue du Docteur Roux
              75724 Paris Cedex 15
              To the attention of Directeur General

    or to such other addresses as the addressees shall indicate in
    accordance with the provisions of this Section.  All notices or
    communications shall be hand delivered against a receipt signed
    and dated by the addressee, or sent by registered mail with
    return receipt requested or by overnight delivery, and shall be
    deemed to have been received on the date stated on the receipt
    by the addressee for hand delivery, or three (3) days after the
    date of the postmark on the receipt of mailing, for registered
    mail or the date of deposit with the overnight delivery service.

    11.10  Costs

    The Purchaser and the Sellers shall each be responsible for
    payment of all fees and costs respectively incurred in connection
    with this Agreement and the operations contemplated herein, including
    the fees and disbursements of their respective financial advisors,
    auditors and attorneys.

    11.11  Governing Law

    This Agreement shall be governed by the laws of France.

    11.12  Disputes

    The Parties undertake to attempt to settle amicably
    and in good faith any dispute that may arise under this
    Agreement.  In the absence of such a settlement, disputes
    thereunder shall be finally resolved under the Rules of
    Arbitration of the Court of Arbitration of the International
    Chamber of Commerce (the "ICC"), as in effect upon commencement
    of the arbitration proceedings, by three (3) arbitrators
    appointed in accordance with said Rules.  The place of the
    arbitration shall be Paris, France and all related proceedings
    shall be conducted in the English language.

    <PAGE>
                                                                   42.

    Made in Paris, on July 3, 1999, in three (3) original counterparts.





    SANOFI-SYNTHELABO                  BIO-RAD LABORATORIES INC.



    /s/  Christian Mignon              /s/  David Schwartz
  _______________________              _______________________
    By:  Christian Mignon              By:  David Schwartz
         Duly authorized                    Duly authorized




    INSTITUT PASTEUR


    /s/ Jean Castex
    _______________________
    By: Jean Castex
        Duly authorized


    <PAGE>

                               TABLE OF CONTENTS

                                                                         Page

    ARTICLE 1 DEFINITIONS..................................................2

    ARTICLE 2 SALE AND PURCHASE OF THE SHARES AND ANCILLARY ASSETS.........6

    2.1       The Shares ..................................................6

    2.1.1     Sale and Purchase of the Shares..............................6

    2.1.2     Share Purchase Price.........................................6

    2.1.3     Share Purchase Price Adjustment..............................6

    2.2       Ancillary Assets.............................................9

    2.2.1     Sale and Purchase of the Ancillary Assets....................9

    2.2.2     Ancillary Asset Purchase Price...............................9

    2.2.3     Ancillary Asset Purchase Price Adjustment...................10

    ARTICLE 3 REPRESENTATIONS OF THE PURCHASER............................11

    3.1       Organization, Authority and Validity........................11

    3.2       No Breach...................................................11

    3.3       Consents....................................................11

    3.4       Brokers.....................................................12

    ARTICLE 4 REPRESENTATIONS OF THE SELLERS..............................12

    4.1       Organization, Authority and Validity........................12

    4.2       No Breach...................................................13

    4.3       Consents....................................................14

    4.4       Incorporation, Existence and Authority of the
               Group Companies............................................14

    4.5       Capital Structure...........................................14

    4.6       Transferability of the Shares...............................14

    4.7       Financial Statements........................................14

    4.8       Real Estate.................................................15

    4.9       Movable Property, Businesses ("Fonds de Commerce")
               and Inventory..............................................15

    4.10      Intellectual Property Rights................................16

    4.11      Loans.......................................................18

    4.12      Tax, Social Security and Customs............................18

    4.13      Insurance...................................................19

    4.14      Contracts...................................................19

                                        -i-

    <PAGE>

                                 TABLE OF CONTENTS
                                    (continued)

                                                                         Page

    4.15      Relations with the Sellers..................................20

    4.16      Disputes....................................................20

    4.17      Compliance with Law.........................................20

    4.18      Environment.................................................21

    4.19      Ancillary Assets............................................21

    4.20      Labor Matters...............................................21

    4.21      Product Liability...........................................22

    4.22      Brokers.....................................................23

    4.23      No Material Adverse Change..................................23

    4.24      Year 2000 Compliance........................................23

    4.25      Euro Compliance.............................................23

    4.26      Maintenance of Business.....................................23

    ARTICLE 5 COVENANTS OF THE SELLERS....................................23

    5.1       Management of the Group Companies between the date
               hereof and the Closing Date................................23

    5.2       Consents / HCV License......................................24

    5.3       Reasonable Access...........................................26

    5.4       Services Agreements.........................................26

    5.5       Termination of the Shareholders' Agreement  -
               Amendment to Cooperation Agreement.........................26

    5.6       Transfer of Sanofi IVD Patents............................. 26

    5.7       Non compete.................................................27

    5.8       Undertaking of IP...........................................27

    5.9       Specific Indemnification of Certain Disclosed Items.........27

    ARTICLE 6 COVENANTS OF THE PURCHASER..................................29

    6.1       Certain Guarantees and Repayments...........................29

    6.2       Employee Benefit Matters....................................29

    6.3       Use of the "Sanofi" Name....................................30

    6.4       Guarantees of the Sellers not released at Closing...........30

    6.5       US GAAP Financial Statements................................30

                                     -ii-

    <PAGE>

                                 TABLE OF CONTENTS
                                    (continued)

                                                                         Page

    ARTICLE 7 ANCILLARY ASSETS............................................31

    7.1       ............................................................31

    7.2       ............................................................31

    7.3       ............................................................31

    7.4       ............................................................31

    7.5       ............................................................31

    ARTICLE 8 INDEMNIFICATION.............................................32

    8.1       Principle...................................................32

    8.2       Claims......................................................33

    8.3       Deadlines for Claims........................................33

    8.4       Third-Party Claims..........................................33

    8.5       Effective Nature of the Loss................................33

    8.6       Determination of the Indemnification........................34

    8.7       Exonerating and Mitigating Factors..........................35

    8.8       Exclusivity of Remedy.......................................35

    8.9       No Other Representations....................................35

    ARTICLE 9 CLOSING.....................................................35

    9.1       Date and Place of Closing...................................35

    9.2       Closing Transactions........................................36

    ARTICLE 10 CONDITIONS PRECEDENT - TERMINATION.........................37

    10.1      Conditions Precedent........................................37

    10.2      Termination.................................................38

    ARTICLE 11 GENERAL PROVISIONS.........................................39

    11.1      Cooperation.................................................39

    11.2      Confidentiality and Announcements...........................39

    11.3      Absence of Third-Party Rights - Assignment..................39

    11.4      Entire Agreement............................................40

    11.5      Waivers and Amendments......................................40

    11.6      Severability................................................40

    11.7      Section Headings............................................40

                                    -iii-

    <PAGE>

                                 TABLE OF CONTENTS
                                    (continued)

                                                                         Page

    11.8      Representation..............................................40

    11.9      Notices and Communications..................................41

    11.10     Costs.......................................................41

    11.11     Governing Law...............................................41

    11.12     Disputes....................................................41














                                    -iv-


   <PAGE>

      LIST OF EXHIBITS & SCHEDULES TO THE PURCHASE AGREEMENT



   Reference in
   the Purchase  Description of the Exhibit or the Schedule
    Agreement

   Exhibit A     Organizational Chart of the Group Companies

   Exhibit B     List of the Ancillary Asset Sellers

   Exhibit C     Detailed list of the Ancillary Assets and Net
                 book value of the Ancillary Assets

   Exhibit D     Method used for the calculation of the Consolidated
                 Reference Net Worth ("Calculation Method")

   Exhibit E     Method used for the calculation of the Consolidated
                 Closing Date Net Worth ("June Calculation")

   Exhibit F     Letters of Ernst & Young dated April 22, 1999

   Exhibit G     Calculation of the Consolidated EBITDA

   Sched. 4.2.1  Events in which the execution of the Agreement or
                 the performance by Sanofi of its obligations
                 thereunder or the consummation of the transactions
                 contemplated thereby does or will:
                 (i)   conflict with or violate any provision of the
                 by-laws or any other corporate govenance document
                 of Sanofi or of any Group Company; or
                 (ii)  to Sanofi's best knowledge, violate, conflict
                 with or result in the breach of any Contract
                 to which Sanofi or any Group Company is a party; or
                 (iii) constitute a violation by it or any Group Company
                 of any laws or regulations.

  Sched. 4.2.2   Events in which the execution of the Agreement or the
                 performance by IP of its obligations thereunder or the
                 consummation of the transactions contemplated thereby
                 does or will:
                 (i)   conflict with or violate any provision of the
                 by-laws or any other corporate govenance document
                 of IP or of any Group Company; or
                 (ii)  to IP's best knowledge, violate, conflict with or
                 result in the breach of any Contract to which IP or
                 any Group Company is a party; or
                 (iii) constitute a violation by it or any Group Company
                 of any laws or regulations.

  Sched. 4.3.1   List of consents to be obtained by Sanoft or any Group
                 Company in connection with the execution of the Agreement
                 or the consummation of any of the transactions contemplated
                 therein

  Sched. 4.3.2   List of consents to be obtained by IP or any Group Company
                 in connection with the execution of the Agreement or the
                 consummation of any of the transactions contemplated
                 therein

  Sched. 4.4.1   Number of shares, directly or indirectly, owned by Sanofi
                 in the Company and its Subsidiaries

   <PAGE>



  Reference in
  the Purchase       Description of the Exhibit or the Schedule
   Agreement

  Sched. 4.4.2   Number of shares, directly or indirectly, owned by
                 IP in the Company and its Subsidiaries

  Sched.         List of the Group Companies indicating their jurisdiction
  4.4.3 (a)      of incorporation, their shareholding and any interest
                 they may have in other Entities

  Sched.         List of the Group Companies that are subject to voluntary
  4.4.3 (d)      or juridicial reorganization proceedings, or similar
                 proceedings or that are undergoing a liquidation

  Sched. 4.5(a)  Liens affecting the Shares or any shares and other equity
                 interests in the Subsidiaries

  Sched. 4.6     Number and purcentage of the Shares owned by Sanofi and IP

  Sched.         Proforma 1998 Financial Statements
  4.7(a)(i)

  Sched.         Sanofi Group Accounting Principles
  4.7(a)(ii)

  Sched.         Diagnostics Division specific Accounting Principles
  4.7(a)(iii)

  Sched.         Material liabilities of the Group Companies as of
  4.7(a)(iv)     December 31, 1998, not reflected or not reserved against
                 in the Proforma 1998 Financial Statements

  Sched.         List of senior management of the Group Companies
  4.7(b)(i)

  Sched.         Since December 31, 1998:
  4.7(b)(ii)     (i)   exceptions to the conduct of the business of
                 the Group Companies in the ordinary course of
                 business and in a manner consistent with past
                 practice,
                 (ii)  distribution of dividends, modifications to the
                 by-laws, or modifications to the share capital of the
                 Group Companies and
                 (iii) liabilities incurred by the Group Companies out
                 of the ordinary course of business and that had a
                 material adverse effect on their financial condition

  Sched. 4.8(a)  List of all real estate owned or leased by the Group
                 Companies, including all land and buildings used for
                 purposes of carrying out their activities

  Sched. 4.8(b)  Liens affecting the value or the use of the Real Estate
                 owned by the Group Companies

  Sched. 4.8(c)  Real Estate not owned by the Group Companies and leased
                 pursuant to non valid lease agreements

  <PAGE>



  Reference in
  the Purchase   Description of the Exhibit or the Schedule
    Agreement

  Sched. 4.9(a)  Movable property, installations and equipment, used
                 by the Group Companies to conduct their businesses,
                 that either are (i) subject to Liens (for owned movable
                 property) or (ii) leased under the terms of a non valid
                 lease, operating lease or capital lease agreement

  Sched. 4.9(b)  Businesses that (i) have not been operated, in all
                 material respect, in accordance with currently applicable
                 laws and regulations or (ii) are not fully owned by
                 the Group Companies or (iii) are affected by Liens

  Sched.         (i) List of all patents, patent applications, registered
  4.10.1(a)      trademarks, trademark applications, owned by the Group
                 Companies,
                 (ii) List of licenses granted to the Group Companies in
                 connection with patents, patent applications, registered
                 trademarks, trademark applications, know-how and
                 intellectual property rights to monoclonal antibodies,
                 except pursuant to the Cooperation Agreement,
                 (iii) Indicative list of cell lines and monoclonal
                 antibodies held by the Group Companies

  Sched.         Intellectual Property Rights (except for Sanofi IVD
  4.10.1(b)      Patents) not owned or used pursuant to license agreements
                 by the Group Companies and Intellectual Property Rights
                 owned by the Group Companies (or by Sanofi for Sanofi IVD
                 Patents) that are subject to any Liens (with the exception
                 of rights granted to third parties pursuant to license
                 agreements) or are no longer enforceable as a result of
                 non-compliance with the formalities required to maintain
                 them in full force and effect or the failure to use such
                 Intellectual Property Rights

  Sched.         Absence of valid title to the Intellectual Property Rights
  4.10.1(c)      owned by the Group Companies (or by Sanofi for Sanofi IVD
                 Patents)

  Sched.         Licenses or other rights to use any of the Intellectual
  4.10.1(d)      Property Rights granted, or agreed to be granted, to any
                 third party by the Group Companies

  Sched.         Intellectual Property Rights used but not owned by the
  4.10.1(e)      Group Companies that are not used by the Group Companies
                 pursuant to valid license agreements; material breaches
                 under any of the license agreements; summary description
                 of proceedings and claims currently outstanding against
                 the Group Companies in respect of the Intellectual
                 Property Rights

  Sched.         Obligations of payment by the Group Companies in connection
  4.10.1(f)      with the ownership or use of the Intellectual Property
                 Rights other than (aa) fees payable to their intellectual
                 property counsels and to competent authorities to
                 maintain their Intellectual Property Rights in full force
                 and effect and (bb) with respect to Intellectual Property
                 Rights not owned by them, the royalties and cash payments
                 provided in the corresponding license agreement

  Sched.         Alterations or impairments of the Group Companies' rights
  4.10.1(g)      under license agreements that may be caused by the
                 consummation of the contemplated transaction

  <PAGE>



  Reference in
  the Purchase   Description of the Exhibit or the Schedule
   Agreement

  Sched.         List of patents, registered trademarks and know-how owned
  4.10.2(a)(i)   in whole or in part by IP and currently used by all or
                 certain of the Group Companies or that the Group
                 Companies, are entitled to use, in each case in the
                 field of the IVD Activities, pursuant to the Cooperation
                 Agreement (the IP Patents and Trademarks")

  Sched.         IP Patents and Trademarks licensed on a non-exclusive
  4.10.2(a)(ii)  basis

  Sched.         IP Patents and Trademarks that are not owned or co-owned
  4.10.2(b)      by IP pursuant to valid tittle and co-owned IP Patents
                 and Trademarks in respect of which IP is not entitled
                 to grant licenses to third-parties pursuant to a
                 management agreement relating thereto

  Sched.         IP Patents and Trademarks subject to Liens or that are
  4.10.2(c)      not enforceable as a result of non-compliance with the
                 formalities required to maintain them in full force
                 and effect or the failure to use such Patents and
                 Trademarks

  Sched.         Licenses or other rights to use those of the IP Patents
  4.10.2(d)      and Trademarks licensed to the Group Companies, on an
                 exclusive basis, that are granted by IP or agreed to be
                 granted by IP to any third parties

  Sched.         Summary description of proceedings and claims currently
  4.10.2(e)      outstanding against IP or the Group Companies in respect
                 of the IP Patents and Trademarks

  Sched. 4.11    Outstanding loans granted to any individual or legal
                 entity by the Group Companies, with the exception of
                 customary loans to employees or bodies responsible for
                 the collection of employer's construction fund
                 contribution and loans granted to other Group Companies

  Sched. 4.12(a) Representations and warranties specific to the US
                 Subsidiaries

  Sched. 4.12(b) (i) Reports and returns in respect of Taxes that were
                 not filed by the Group Companies on a timely basis with
                 the competent authorities and reports and returns that
                 were not true and accurate in all material respects when
                 Filed,
                 (ii) Taxes required to be paid by the Group Companies
                 that were due and payable prior to the date hereof that
                 have not been paid by the Group Companies and
                 (iii) insufficient provisions in the Proforma 1998
                 Financial Statements, in connection with the payment of
                 all Taxes that were not due and payable prior to
                 January 1, 1999 but for which the Group Companies may
                 be liable in respect of periods ending prior to January 1,
                 1999, regardless of whether the liability for such Taxes
                 is disputed

  Sched. 4.12(c) Group Companies subject to audits or investigations by a
                 competent authority regarding Taxes

  Sched. 4.13(a) List of insurance policies in effect

  Sched. 4.13(b) List of material pending claims or disputes in connection
                 with insurance policies

  <PAGE>



  Reference in
  the Purchase   Description of the Exhibit or the Schedule
   Agreement

  Sched. 4.14(a) List of all Contracts (except for license
                 agreements relating to Intellectual Property Rights)
                 between any of the Group Companies and a third party,
                 that (i) involve the obligation (including contingent
                 obligation) by or to any of the Group Companies to pay
                 amounts in excess of one million French Francs in any
                 year (on the basis of the Proforma 1998 Financial
                 Statements) or (ii) were not entered into in the ordinary
                 course of business of the Group Companies

  Sched. 4.14(b) Contracts listed in Schedule 4.14(a) that are not valid,
                 binding or enforceable by one or more of the Group
                 Companies in accordance with their respective terms and
                 Contracts listed in Schedule 4.14(a) under which any
                 party thereto is materially in default

  Sched. 4.14(c) Contracts listed in Schedule 4.14(a) providing for a
                 clause pursuant to which any other party to such
                 Contracts may request that they be terminated,
                 modified or renegotiated, as a result of the
                 contemplated transaction

  Sched. 4.15    (i) Properties and rights whatsoever, that are
                 necessary for the Group Companies to carry out their
                 activities (other than the IP Patents and Trademarks)
                 held by any of the Sellers;
                 (ii)Contracts with any Group Companies to which any of
                 the Sellers is party and rights against the Group
                 Companies held by any of the Sellers (other than
                 the shareholders' rights of the Sellers vis-a-vis
                 the Group Companies, Sanofi's rights to the Sanofi IVD
                 Patents and IP's rights under the Cooperation Agreement
                 and the licenses of the IP Patents and Trademarks to
                 the Group Companies); and
                 (iii)guarantees or other security interests securing
                 any of the Group Companies' undertakings granted by any
                 of the Sellers and guarantees granted by any of the Group
                 Companies to secure any of the Sellers' obligations
                 vis-a-vis third parties

  Sched. 4.16    Summary description of judicial, administrative or
                 arbitration proceedings pending against any of the Group
                 Companies, which would have a material adverse effect on
                 its business condition or the economic or financial
                 prospects of the Group Companies taken as a whole

  Sched. 4.17    (i) Permits and other consents required to conduct
                 the respective operations of the Group Companies as
                 currently being conducted that are not possessed by them;
                 and
                 (ii) non-compliance with these permits or consents or
                 with any laws or regulations currently applicable to the
                 Group Companies in the conduct of their operations
                 (except for instances of non-compliance that would not
                 reasonably be expected to have a material adverse effect
                 on the relevant Group Company)


  <PAGE>



  Reference in
  the Purchase   Description of the Exhibit or the Schedule
   Agreement

  Sched. 4.18    Activities carried out by the Group Companies
                 that do not comply with environmental laws or
                 regulations currently applicable to them; environmental
                 authorizations and licenses required for the conduct
                 of the Group Companies' operations as currently conducted
                 that have not been obtained by the Group Companies,
                 and non-compliance with said authorizations and licenses

  Sched. 4.19(a) (i) Ancillary Assets that are not wholly-owned by the
                 Ancillary Asset Sellers and/or (ii) Liens affecting
                 the Ancillary Assets

  Sched. 4.20(a) List of the employees of the Group Companies (including
                 the US Subsidiaries) and of the Ancillary Asset Employees;
                 description of liabilities relating to such employees

  Sched. 4.20(b) List of retirement plans, profit-sharing schemes and
                 optional employee plans to which the Group Companies
                 participate or contribute, other than those legally
                 required

  Sched. 4.20(c) List of contracts concluded between any Group Company
                 and its employees, which provide, in the event of
                 termination, for a notice period or payment of an
                 indemnity which exceeds those provided for by applicable
                 laws, regulations and/or collective bargaining agreements

  Sched. 4.20(d) Outstanding commitments and undertakings made by the Group
                 Companies (including the US Subsidiaries) and of the
                 Ancillary Asset Employees vis-a-vis their former employees

  Sched. 4.20(e) Undertakings given or commitments made by the Group
                 Companies in connection with any restructuring plan (plan
                 social) or dismissal plan (licenciement collectif)
                 that have not been entirely performed or fulfilled

  Sched. 4.20(f) Summary description of current labor litigation involving
                 claims by employees of the Group Companies

  Sched. 4.20(g) Undertakings given by the Group Companies including the
                 US Subsidiaries and of the Ancillary Asset Employees to
                 their employees in connection with the contemplated
                 transaction

  Sched. 4.20(h) Ancillary Asset Employees for whom none of the
                 representations and warranties contained in Section 4.20
                 are made

  Sched. 4.21(a) Product recalls

  Sched. 4.2l(b) Warranties granted by any of the Group Companies with
                 respect to its products under the terms of which any of
                 them would be liable beyond the limits and periods
                 provided for by law and/or the general conditions of sale
                 of the Group Companies, as applicable

  Sched. 4.24    Presentations, reports and memoranda relating to Y2K

  <PAGE>



  Reference in
  the Purchase   Description of the Exhibit or the Schedule
   Agreement

  Sched. 4.25    Presentations, reports and memoranda relating to Euro

  Sched. 5.2     List of Change of Control Contracts

  Sched. 5.4(a)  Services agreements, between Sanofi or its Affiliates,
                 on the one hand, and the Group Companies, on the other
                 hand, that shall terminate on the Closing Date

  Sched. 5.4(b)  Services agreements that shall remain in effect,
                 between Sanofi or its Affiliates, on the one hand, and
                 the Group Companies, on the other hand, for a renewable
                 6 month period following the Closing Date

  Sched. 5.4(c)  Agreements that shall remain in effect, between Sanofi
                 or its Affiliates, on the one hand, and the Group
                 Companies, on the other hand, after the Closing Date,
                 according to their terms and conditions

  Sched. 5.6     List of the Intellectual Property Rights currently
                 registered under Sanofi`s name or under the name of any
                 of its Affiliates (the "Sanofi IVD Patents")

  Sched. 6.1(a)  List of guaranties extended by Sanofi to the Group
                 Companies that will be maintained after the Closing Date

  Sched. 6.2(a)  Copy of Sanofi Group profit-sharing plans applicable to
                 certain of the Group Companies

  Sched. 6.2(b)  Terms and conditions of the transfer of financial assets
                 and of the benefit obligations relating to the employees
                 of US Subsidiaries

  Sched. 7.1     List of the Ancillary Asset Employees

  Sched. 7.3(b)  List of the Ancillary Assets subject to reorganization
                 before being transferred to the Purchaser and description
                 of the reorganization to be implemented

  Sched. 8.l(b)  Additional indemnification and Tax matters relating to
                 the US Subsidiaries



   <PAGE>

                                                     Exhibit 99.1
   News Release

    BIO-RAD, SANOFI-SYNTHELABO AND INSTITUT PASTEUR SIGN DEFINITIVE
      AGREEMENT FOR THE ACQUISITION OF PASTEUR SANOFI DIAGNOSTICS

   HERCULES, CA   Bio-Rad Laboratories, Inc. (AMEX: BIO.A and BIO.B)
   announced today the acceptance of its acquisition bid for Pasteur
   Sanofi Diagnostics (PSD) by  Sanofi-Synthelabo S.A. and  Institut
   Pasteur, the shareholders of  PSD. According to the terms  of the
   definitive agreement, Bio-Rad will acquire  100% of the shares of
   (and certain assets and assumed liabilities related to) PSD for a
   purchase price of $210,000,000.

   Financing has  been committed  by Banc  One. Finalization  of the
   transaction is expected within approximately ninety days to allow
   for  financial arrangements and  necessary regulatory  review and
   clearance.

   Bio-Rad expects  diagnostics sales  to increase  to approximately
   $400 million as a  result of the acquisition, moving  the Company
   into  the  top ten  in  the diagnostics  industry.  The composite
   portfolio  of the  combined  organizations  affords  Bio-Rad  the
   ability  to  provide  products   and  services  to  the  clinical
   laboratory  across a  broad spectrum  of departments  and disease
   states, including tests for blood virus, bacteriology, infectious
   disease,  diabetes  monitoring,  genetic  disease  screening, and
   quality control management.

   The acquisition also includes  a collaboration agreement with the
   Institut Pasteur,  giving  Bio-Rad a  priority  to  commercialize
   Pasteur s discoveries in the In Vitro diagnostics market. Bio-Rad
   views this relationship as a significant competitive advantage in
   the  infectious  disease  market and  anticipates  expanding  the
   alliance towards the continued success of both organizations.

   Bio-Rad  Laboratories  President  and CEO,  David  Schwartz said,
    This acquisition places us  in a more favorable position  in the
   diagnostics market. It gives us a significant presence in all key
   geographic areas, including the emerging economies, as well as  a
   substantial product  offering in  market segments  showing strong
   long-term growth.

   Bio-Rad Laboratories,  Inc. (www.bio-rad.com) is  a multinational
   manufacturer  and distributor of  life science research products,
   clinical  diagnostics  and analytical  instrumentation,  based in
   Hercules,  California.  The  company  serves  more  than   70,000
   research and industry customers worldwide through a network of 25
   wholly-owned subsidiary offices.

   For more information, contact:
   Contact:  Tom Chesterman, Vice President and Chief Financial Officer
   Phone:    (510) 741-6006
   Email:    [email protected]

   Date: July 5, 1999                 For Release: 9 a.m. (P.S.T.)




© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission