BIOSPHERICS INC
S-3/A, 1998-03-23
ENGINEERING, ACCOUNTING, RESEARCH, MANAGEMENT
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<PAGE>


     As filed with the Securities and Exchange Commission on March 23, 1998
                           Registration No. 333-44973

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 AMENDMENT NO. 2
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933

                            BIOSPHERICS INCORPORATED
             (Exact name of Registrant as specified in its charter)

         Delaware                                                52-0849320
(State or other jurisdiction of incorporation or organization)(IRS employer
identification no.)

      12051 Indian Creek Court, Beltsville, Maryland 20705, (301) 419-3900
    (Address, including zip code, and telephone number,including area code,
                  of Registrant's principal executive offices)

Gilbert V. Levin, President and Chief Executive Officer, Biospherics 
Incorporated
      12051 Indian Creek Court, Beltsville, Maryland 20705, (301) 419-3900
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                   Copies to:
                               James E. Baker, Jr.
                        Baxter, Baker, Sidle & Conn, P.A.
                       120 E. Baltimore Street, Suite 2100
                            Baltimore, Maryland 21202

Approximate date of commencement of proposed sale to the public: From time to 
time after the effective date of this Registration Statement.

If the only securities being registered on this Form are being offered 
pursuant to dividend or interest reinvestment plans, please check the 
following box. [ ]

If any of the securities being registered on this Form are to be offered on a 
delayed or continuous basis pursuant to Rule 415 under the Securities Act of 
1933, other than securities offered only in connection with dividend or 
interest reinvestment plans, check the following box. [X]

If this Form is filed to register additional securities for an offering 
pursuant to Rule 462(b) under the Securities Act, please check the following 
box and list the Securities Act registration statement number of the earlier 
effective registration statement for the same offering.[ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) 
under the Securities Act, check the following box and list the Securities Act 
registration statement number of the earlier effective registration statement 
for the same offering. [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]


<PAGE>


<TABLE>
<CAPTION>

                                                CALCULATION OF REGISTRATION FEE

 Title of Each Class                             Proposed Maximum       Proposed Maximum
 of Securities to be                              Offering Price           Aggregate              Amount of
      Registered            Amount to be          Per Share (1)        Offering Price (1)        Registration
                             Registered                                                              Fee
- -----------------------------------------------------------------------------------------------------------------
<S>                            <C>                   <C>                     <C>                      <C>    
Common Stock                   1,620,000             $4.4375                 $7,188,750               $2,121 (1)
($.005 par value)
</TABLE>


     (1) Estimated solely for the purpose of calculating the amount of the
         registration fee, pursuant to Rule 457(c) under the Securities Act,
         based on the last sales price of the Common Stock on the NASDAQ
         National Market System on January 21, 1998.

The shares of Common Stock registered hereunder include (i) 750,000 shares of 
Common Stock issued to a Selling Shareholder in connection with a private 
placement transaction completed on December 12, 1997 (the "Private 
Placement"), (ii) 750,000 shares of Common Stock issuable to a selling 
shareholder upon exercise of warrants issued in connection with the Private 
Placement (the "Private Placement Warrants") and (iii) 120,000 shares of 
Common Stock issuable upon exercise of other warrants held by other Selling 
Shareholders (the "Wharton Warrants" and, together with the Private Placement 
Warrants, the "Warrants"). In addition to the shares set forth in the table, 
which represents a good faith estimate of the number of shares underlying the 
Warrants, the amount to be registered includes an indeterminate number of 
shares issuable upon exercise of or in respect of the Warrants, as such 
number may be adjusted as a result of stock splits, stock dividends and 
antidilution provisions in accordance with Rule 416.

The registrant hereby amends this Registration Statement on such date or 
dates as may be necessary to delay its effective date until the Registrant 
shall file a further amendment which specifically states that this 
Registration Statement shall thereafter become effective in accordance with 
Section 8(a) of the Securities Act of 1933 or until the Registration 
Statement shall become effective on such date as the Commission, acting 
pursuant to said Section 8(a), may determine.

<PAGE>



This Preliminary Prospectus and the information contained herein are subject 
to completion or amendment. These securities may not be sold, nor may offers 
to buy be accepted, prior to the time the Prospectus is delivered in final 
form. Under no circumstances shall this Preliminary Prospectus constitute an 
offer to sell or the solicitation of an offer to buy nor shall there be any 
sale of these securities in any jurisdiction in which such offer, 
solicitation or sale would be unlawful prior to registration or qualification 
under the securities laws of any such jurisdiction.

                   Subject to Completion dated March 23, 1998

                                   PROSPECTUS
                        1,620,000 Shares of Common Stock
                            BIOSPHERICS INCORPORATED

This prospectus (this "Prospectus") relates to the offer and sale of up to
1,620,000 shares (the "Shares") of Common Stock, $.005 par value (the "Common
Stock"), of Biospherics Incorporated ("Biospherics" or the "Company").

The Shares will be offered for sale by certain stockholders of the Company 
(the "Selling Shareholders") or by their respective pledgees, donees, 
transferees or other successors in interest, from time to time in one or more 
transactions (which may involve block transactions) effected on the NASDAQ 
National Market System (or on any national securities exchange or U.S. 
inter-dealer quotation system of a registered national securities association 
on which the Shares are then listed), in sales occurring in the public market 
of such exchange, in privately-negotiated transactions, through the purchase 
or writing of options on the Shares, in short sales or in a combination of 
such methods of sale. Such methods of sale may be conducted at market prices 
prevailing at the time of sale, at prices related to such prevailing market 
price or at negotiated prices. The Selling Shareholders may effect such 
transactions directly, or indirectly through broker-dealers or agents acting 
on their behalf, and in connection with such sales, such broker-dealers or 
agents may receive compensation in the form of commissions or discounts from 
the Selling Shareholders and/or the purchasers of the Shares for whom they 
may act as agent or to whom they sell Shares as principal or both (which 
commissions or discounts are not anticipated to exceed those customary in the 
types of transactions involved). To the extent required, the names of any 
agents or broker-dealers, and applicable commissions or discounts and any 
other required information with respect to any particular offer of Shares by 
the Selling Shareholders, will be set forth in a Prospectus Supplement. Any 
securities covered by this Prospectus which qualify for sale pursuant to Rule 
144 under the Securities Act of 1933, as amended (the "Securities Act"), may 
be sold pursuant to Rule 144 rather than pursuant to this Prospectus. See 
"Selling Shareholders" and "Plan of Distribution".

While the Company will receive proceeds from the exercise of Warrants, it 
will not receive any of the proceeds from the sale of the Shares. See 
"Selling Shareholders" for information with respect to Shares held or 
acquirable by the Selling Shareholders. The Company will pay the expenses of 
registration estimated at $29,621. The Selling Shareholders and any dealer 
acting in connection with the offering of any of the Shares or any broker 
executing selling orders on behalf of the Selling Shareholders may be deemed 
to be "underwriters" within the meaning of the Securities Act, in which event 
any profit on the sale of any or all of the Shares by them and any discounts 
or commissions received by any such brokers or dealers may be deemed to be 
underwriting discounts and commissions under the Securities Act.

                                       1

<PAGE>


The Common Stock of Biospherics is quoted on the NASDAQ National Market System
under the symbol "BINC."

On January 21, 1998 the closing price of the Common Stock on the NASDAQ National
Market System was $4.4375 per share.

SEE "RISK FACTORS" COMMENCING ON PAGE 9 FOR A DISCUSSION OF CERTAIN FACTORS 
THAT SHOULD BE CONSIDERED IN CONNECTION WITH AN INVESTMENT IN THE COMMON 
STOCK OFFERED HEREBY.

THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND 
EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE SECURITIES 
AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE 
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY 
IS A CRIMINAL OFFENSE.

                 The date of this Prospectus is March 23, 1998.


                                       2

<PAGE>


                              AVAILABLE INFORMATION

The Company is subject to the informational requirements of the Securities 
Exchange Act of 1934, as amended (the "Exchange Act"), and, in accordance 
therewith, files reports, proxy statements and other information with the 
Securities and Exchange Commission (the "Commission"). Such reports, proxy 
statements and other information filed by the Company can be inspected and 
copied at the public reference facilities of the Commission located at Room 
1024, Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549, and at 
the Commission's regional offices at Seven World Trade Center, 13th Floor, 
New York, New York 10048; and Northwestern Atrium Center, 500 West Madison 
Street, Suite 1400, Chicago, Illinois 60661-2511. Copies of such material can 
also be obtained from the Public Reference Section of the Commission at Room 
1024, Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549 at 
prescribed rates. The Commission also maintains a World Wide Web site 
(located at http://www.sec.gov) that contains reports, proxy and information 
statements and other information regarding the Company. The Common Stock is 
listed on the NASDAQ National Market System and reports, proxy statements and 
other information concerning the Company may be inspected at the offices of 
the NASDAQ Stock Market, 1735 K Street, N.W., Washington, D.C. 20006-1500.

The Company has filed with the Commission a Registration Statement on Form 
S-3 under the Securities Act with respect to the Shares offered hereby. This 
Prospectus does not contain all of the information set forth in the 
Registration Statement and the exhibits thereto. For further information with 
respect to the Company and the Common Stock offered hereby, reference is made 
to the Registration Statement and the exhibits filed therewith or 
incorporated therein by reference. Regarding statements contained in this 
Prospectus as to the contents of any contract or any other document referred 
to herein, reference is made to the copy of such contract or other document 
filed as an exhibit to the Registration Statement or incorporated therein by 
reference, each such statement being qualified in all respects by such 
reference. A copy of the Registration Statement may be inspected, without 
charge, at the offices of the Commission in Washington, D.C. and copies of 
all or any part of the Registration Statement may be obtained from the Public 
Reference Section of the Commission at Room 1024, Judiciary Plaza, 450 Fifth 
Street, N.W., Washington, D.C. 20549, upon the payment of the fees prescribed 
by the Commission.

No dealer, salesperson or other person has been authorized to give any 
information or to make any representation not contained in this Prospectus 
and, if given or made, such information or representation must not be relied 
upon as having been authorized by the Company or any Selling Shareholder. 
This Prospectus does not constitute an offer to sell or a solicitation of an 
offer to buy any of the securities offered hereby in any jurisdiction to any 
person to whom it is unlawful to make such offer or solicitation in such 
jurisdiction. Neither the delivery of this Prospectus nor any sale made 
hereunder shall, under any circumstances, create any implication that the 
information herein is correct as of any time subsequent to the date hereof or 
that there has been no change in the affairs of the Company since such date.

                                       3

<PAGE>


                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The following documents filed with the Commission are incorporated herein by
reference:

<TABLE>
<S>      <C>
(a)      The Company's annual report on Form 10-KSB for the fiscal year ended
         December 31, 1997.

(b)      The Company's quarterly report on Form 10-QSB for the three months
         ended March 31, 1997.

(c)      The Company's quarterly report on Form 10-QSB for the three months
         ended June 30, 1997.

(d)      The Company's quarterly report on Form 10-QSB for the three months
         ended September 30, 1997.

(e)      The Company's current report on Form 8-K filed on December 18, 1997.

(f)      All other documents filed by the Company pursuant to Sections 13(a),
         13(c), 14 and 15(d) of the Exchange Act following the fiscal year ended
         December 31, 1996 and prior to the termination of the offering
         contemplated hereby.
</TABLE>

Any statement incorporated by reference herein shall be deemed to be modified 
or superseded for purposes of this Prospectus to the extent that a statement 
contained herein or in any subsequently filed document, which also is or is 
deemed to be incorporated by reference herein modifies or supersedes such 
statement. Any statement so modified or superseded shall not be deemed, 
except as so modified or superseded, to constitute part of this Prospectus.

The Company hereby undertakes to provide without charge to each person, 
including any beneficial owner, to whom this Prospectus is delivered, upon 
written or oral request of such person, a copy of any and all of the 
information that has been incorporated by reference in this Prospectus (not 
including the exhibits to the information that is incorporated by reference 
unless such exhibits are specifically incorporated by reference into the 
information that this Prospectus incorporates). Requests should be directed 
to Mr. Jeffrey W. Church, Executive Vice President and Chief Financial 
Officer, 12051 Indian Creek Court, Beltsville, Maryland 20705; telephone 
number (301) 419-3900.

                                       4

<PAGE>


                           FORWARD LOOKING STATEMENTS

Certain statements contained in this Prospectus, including without 
limitation, statements containing the words "believes," "estimates," 
"expects" and words of similar import, constitute "forward looking 
statements." Such words and expressions are intended to identify such forward 
looking statements, but are not intended to constitute the exclusive means of 
identifying such statements. Such forward looking statements involve known 
and unknown risks, uncertainties and other factors that may cause the actual 
results, performance or achievements of the Company, or industry results, to 
be materially different from any future results, performance or achievements 
expressed or implied by such forward looking statements. These risks, 
uncertainties and other factors include, but are not limited to, those 
discussed below under the heading "Risk Factors." Given these uncertainties, 
prospective investors are cautioned not to place undue reliance on such 
forward looking statements. The Company disclaims any obligation to update 
any such factors or to publicly announce the results of any revisions to any 
of the forward looking statements contained herein to reflect any events or 
developments. Investors should also review forward looking statements 
contained in the Company's most recent Annual Report on Form 10-KSB and 
subsequent quarterly reports on Form 10-QSB.

                                   THE COMPANY

General. Biospherics Incorporated (the "Company"), a Delaware corporation, 
was founded in 1967. The Company is engaged in the business of providing (i) 
information services to private industry and to Federal, State and local 
government agencies, and (ii) biological and chemical research services. The 
Company consists of an Information Services Division ("ISD") and a BioTech 
Programs Unit ("BioTech"). As part of BioTech, the Company is also developing 
its own proprietary products. In February 1996, the Company sold its 
Environmental and Laboratory Services Division ("ELSD") to permit better 
focus on the major businesses of the Company, ISD and BioTech.

The principal executive offices of the Company are located at 12051 Indian 
Creek Court, Beltsville, Maryland 20705, and its telephone number is (301) 
419-3900. The Company's Common Stock trades on the NASDAQ National Market 
System under the symbol BINC.

Information Services Division. ISD's information professionals provide 
computerized health, pharmaceutical and medical data collection and clinical 
trial management, report and publication writing and editing, development of 
programmatic concepts in public health information and education, database 
management, reservation services and computer-assisted health resource 
information. ISD collects and disseminates information by providing 
customized telesupport and database management systems that combine the human 
element of live operators with communications technology. ISD answers 
millions of calls annually from professionals and the public nationwide and 
disseminates millions of publications. The core of its operation consists of 
three call centers (Beltsville, Cumberland and Columbia, MD) that efficiently 
manage and track high volumes of calls. The technology is combined with 
computerized database management systems, which results in an efficient and 
effective system to collect and disseminate large amounts of information.

ISD specializes in public health issues and provides information services on 
a wide range of diseases and disabilities, disease prevention, and education. 
Areas of expertise include 

                                       5

<PAGE>


Alzheimer's disease, AIDS, cancer, diabetes, heart disease, and stroke, in 
addition to the broader areas of smoking, aging, and environmental hazards 
such as mishandling of pesticides. Programs are staffed by health 
professionals and other information specialists who are given extensive 
training and are subject to strict quality control guidelines. ISD's clients 
have included some of the major U.S. pharmaceutical companies as well as 
government departments that deal with health or education. ISD holds 
contracts with such agencies as the Department of the Navy, the General 
Services Administration and the Department of Health and Human Services. 
Contracts with non-governmental parties are typically obtained following 
private negotiations and are most often for a term of one year, although many 
such contracts have continued to renew for several years. Contracts with 
governmental parties are obtained after a competitive bidding process and are 
most often for terms ranging from two to three years, with additional option 
years. Many have been re-won numerous times. Significant portions of the 
Company's revenue relate to several government and commercial ISD contracts.

In recent years, the Company has expanded its Government call center business 
to include reservation services for Federal and state agencies. The Company 
has provided these services to the Department of Agriculture (Forest Service) 
since 1994. The Company did not win its re-compete for its reservation 
contract with the Forest Service and will complete that contract on September 
30, 1998. The Forest Service contract has contributed approximately $1.5 
million in annual revenue.

In December 1997, the Company was awarded a reservation contract for the 
National Park Service's National Park Reservation Service (NPRS), which is a 
two-year firm-fixed price contract aggregating $5 million with provision for 
three option years. The NPRS contract requires the Company to establish and 
manage a central call center with information and communication links with 
twenty-five National Parks across the United States. Reservations for 
campsites and tours can be processed through the central call center or at 
the individual parks. In conjunction with the implementation of this 
contract, the Company anticipates capital expenditures for computer software 
and hardware at the central call center as well as the individual parks 
totaling $1 million during 1998.

ISD accounted for over 90% of the Company's total revenues from continuing 
operations in 1996 and 1997. During 1996, government business accounted for 
approximately 57% of ISD's business, increasing to 68% in 1997. This resulted 
primarily from completion of two commercial contracts in October 1995 and 
June 1997. The Company anticipates an increased level of government contracts 
in 1998. Sales and marketing efforts will be intensified to re-establish and 
increase the Company's share of commercial business in response to the high 
level of public interest in health information.

The Company has announced its plan to expand its traditional ISD business via 
a new subsidiary. The new company will focus on expansion of ISD's healthcare 
business into demand management. To that end, on December 12, 1997, the 
Company is pursuing the formation of a new subsidiary. The Company intends to 
transfer its commercial ISD business to this subsidiary to provide it an 
initial base of business. The Company has preliminarily agreed to issue an 
equity interest in the subsidiary to a physician group in exchange for the 
transfer of certain proprietary assets necessary to pursue the demand 
management business. The subsidiary will require a substantial additional 
infusion of capital to commence operations. The subsidiary will attempt to 
secure private placement financing aggregating $10 million over the next two 
years. Initial 

                                       6

<PAGE>


permanent financing (which is likely to include an equity component) is 
expected to finance the subsidiary's working capital needs and anticipated 
operating losses during its first year of operation. Thereafter, the 
subsidiary will require an additional capital infusion of $5 million 
including a working capital line of credit facility. Commencement of 
operations also depends upon finalizing a definitive agreement with the 
physician group.

BioTech Programs Unit. BioTech is the Company's research and development arm, 
dedicated to developing proprietary products and services with a view toward 
commercial applications. Over the last several years, the Company has 
invested more than $3 million in these developments, primarily in its 
nonfattening sugar, D-Tagatose. The Company has accumulated a number of 
patents on its products.

D-Tagatose as a Bulk Sweetener. BioTech has patented the use of a naturally 
occurring sugar, D-Tagatose, as a low-calorie and nonfattening sweetener. It 
is a true sugar that looks, feels, performs, and tastes like table sugar. 
Present in small amounts in many dairy products, it differs from all other 
nonfattening sweeteners in that it has the full bulk of sugar with the same 
clean, sweet taste. Biospherics has been developing the substance since 
receiving a patent for its use as a food additive in 1988 and two patents for 
the production process (1990 and 1991).

In September 1996, the Company signed a license agreement with MD Foods 
Ingredients amba of Denmark (MD Foods) for the exclusive worldwide rights to 
manufacture, market, and distribute D-Tagatose as a food ingredient in return 
for a non-refundable up-front payment and a royalty schedule based upon net 
sales. Under the agreement, MD Foods may sub-license the D-Tagatose 
technology for use in foods and beverages. In return for the exclusive 
license, MD Foods will take responsibility for all future marketing and 
development expenses, including the cost of constructing and operating its 
own production plants. MD Foods manufactures a wide variety of foods and food 
ingredients made from milk. The Danish dairy company ranks as the eighth 
largest dairy products company in the world. It has the largest whey protein 
processing plant, the by-product of which is the raw material for making 
D-Tagatose. MD Foods is widely regarded as a manufacturer of high quality 
products and has the capability for worldwide distribution.

The up-front payment has been made by MD Foods, part in September 1996 and 
part in January 1997. The payment totaled $2.5 million, $1 million of which 
is a non-refundable advance against future royalties. Biospherics will 
receive running royalties from commercial sales of D-Tagatose. MD Foods also 
funds Biospherics for certain technological support. To strengthen their 
cooperative efforts, the two companies established an advisory committee to 
plan and review progress in bringing D-Tagatose to its various world market 
sectors. The committee consists of three MD Foods representatives and one 
Biospherics representative. The committee proposes strategies and actions for 
MD Foods management's consideration.

MD Foods expects to compete for a share of the U.S. market for sweeteners. A 
panel of experts has advised that D-Tagatose may qualify for early entry into 
the U.S. market as a food ingredient that is a Generally Recognized as Safe 
(GRAS). MD Foods has begun design of a commercial plant to manufacture 
D-Tagatose. MD Foods has advised that the decision to proceed with plant 
construction will be deferred until successful GRAS affirmation in the U.S., 
currently anticipated in 1998. The target date for plant start-up is the year 
2000.

                                       7

<PAGE>


The Company believes that D-Tagatose will fill a market not currently 
accessible to other sweetener products. That market initially includes 
chocolate confections, chewing gum, ice cream, and table top sugar. Later on, 
market applications may broaden to include baked goods, heat-processed foods, 
frozen desserts, other dairy products, cereals, and other products in which 
the full bulk of sugar is required. Biospherics believes that chocolate 
candies and chewing gum are excellent introductory uses for its nonfattening 
sugar, because each constitutes a large market and each uses sugar as a major 
ingredient. Manufacturers have long sought a low-calorie substitute for table 
sugar in chocolate candy, which, partly because of its high sugar content, 
none has succeeded in emulating the flavor of table sugar. Also, unlike table 
sugar, D-Tagatose has been shown to cause virtually no tooth decay.

D-Tagatose as an Anti-Hyperglycemic Agent. The Company has received 
additional key patents for the use of D-Tagatose as an anti-hyperglycemic 
agent (1994) and also as a treatment for diabetes (1995). Studies are ongoing 
with respect to this potential use of D-Tagatose. The Company is discussing 
the possibility of licensing the use of D-Tagatose as an anti-hyperglycemic 
agent with a number of pharmaceutical and nutritional products companies, 
while development efforts proceed.

Safe-for-Human-Pesticides. The increasing concern over pesticide hazards in 
foods and the general environment indicates a market for an economical and 
effective product that poses no human threat. In November 1992, the Company 
received U.S. patents for its safe-for-humans pesticides. More development 
work is required in order to develop a commercial insecticide.

L-Sugars. Earlier in its low-calorie sweetener research, the Company obtained 
patents in the U.S. and abroad for the use of a broad group of L-hexose 
sugars for sweetening and bulking foods, beverages, and drugs. To date, no 
economic means for production exists. The Company, however, intends to 
attempt to develop such for some of the L-Sugars.

For now, Biospherics' research efforts and investment are largely devoted to 
continuing to assist MD Foods in the development of D-Tagatose because of the 
near term favorable prospects for this product. While many of the other 
BioTech products described above show much promise, the continued development 
thereof is dependent upon many factors, including but not limited to the 
Company having sufficient funds to devote to such efforts.

Governmental Regulation. The business activities of the Company are subject 
to a variety of Federal and State compliance, licensing, and certification 
requirements. Management believes that the Company is, and has been at all 
times, in full compliance with Federal and State environmental protection and 
worker safety laws. The Company has not incurred significant expense in 
complying with such laws and does not anticipate material expense, except for 
the FDA approval for commercialization of D-Tagatose (which is to be borne by 
MD Foods) and the L-Sugars. Commercialization of D-Tagatose and L-Sugars in 
the United States for use as food additives will require FDA approval. As of 
this date, Biospherics believes that results of its test program warrant 
continuing the development efforts to provide a broad family of low-calorie 
sweeteners.

                                       8

<PAGE>


                                  RISK FACTORS

Investors should consider carefully the following factors, in addition to the 
other information contained in this Prospectus, before purchasing the shares 
of Common Stock offered hereby.

Exclusive License of D-Tagatose. The Company has granted an exclusive 
worldwide license to MD Foods Ingredients amba of Denmark (MD Foods) for the 
manufacture, marketing and distribution of D-Tagatose as a food ingredient. 
Receipt of future payments from MD Foods is dependent upon MD Foods' efforts 
to commercialize this product. MD Foods has yet to commence construction of a 
plant to manufacture D-tagatose. The target date for plant start-up is in 
the year 2000. There can be no assurances as to the timing of such construction 
and/or MD Foods' commercialization activities. While the Company has and 
expects to continue to provide assistance to MD Foods, the commercialization 
of D-Tagatose as a food product is largely outside of the control of the 
Company.

BioTech Product Development. While the Company is in the process of 
attempting to commercialize other potential uses of D-Tagatose as well as to 
develop other products within BioTech, no such other uses of D-Tagatose and 
no such other products have been developed to a stage where any significant 
revenue has been generated. Development of products will require significant 
additional research and development, including process development, extensive 
clinical testing and market research. Such additional effort will require 
substantial funding which may not be available to the Company. As a result, 
the Company's potential products are subject to the risks of failure inherent 
in the development of products based on new technologies. There can be no 
assurance that the Company's research and development activities will result 
in any commercially viable products.

ISD Contract Mix--Current Government Dependence. The Company's ISD business 
is comprised of both government and commercial business. The mix of such 
business changes from period to period. Government business traditionally 
generates lower operating margins than commercial business. In 1997, 
government to commercial business mix was 2 to 1. It is anticipated that the 
swing to dependence on government business will continue in 1998, in part due 
to the loss of a commercial contract with Pharmacia & Upjohn effective March 
31, 1998, which has contributed approximately $1.5 million in annual revenue. 
The Company was unsuccessful in securing the renewal of the Pharmacia & 
Upjohn contract due to a competitive rebid of this program by the customer. 
The Company continues to pursue additional commercial business to better 
balance its government business, including its efforts to initiate the 
Healthcare Opportunity. Further, the Company believes that some of the 
investments it has made, and plans to make, in computer hardware and software 
should increase its operating efficiencies and permit a return to 
profitability even with a predominant government component. However, there is 
no assurance that the Company will be successful in implementing these plans.

ISD Contracts. The principal portion of the Company's revenues has been 
generated traditionally by the ISD unit. Several of the Company's contracts 
provide these revenues (principally contracts with the U.S. Government) are 
in a state of flux. These contracts are awarded pursuant to a competitive 
bidding process. In some cases, the Company is the apparent successful bidder 
for such a contract but one or more unsuccessful parties have filed protests 
challenging the final award of these contracts to the Company. In other 
cases, another party is the apparent successful bidder for such a contract 
and the Company has filed a protest 

                                       9

<PAGE>

challenging the final award of a contract. In addition, substantial portions 
of the Company's revenue have been historically generated by several 
commercial ISD contracts. Such contracts are typically for one year terms. 
Although the Company believes that it will retain/acquire contracts to 
continue to generate sufficient revenue to maintain the Company in accordance 
with past practices, there can be no assurance thereof.

Healthcare Information and Management Opportunity. The Company has announced 
plans to expand its traditional information systems business to include 
providing demand management information services to HMO's, other group health 
organizations, insurers and employees in company health plans (the 
"Healthcare Opportunity"). The Company intends to pursue the Healthcare 
Opportunity by forming a new subsidiary, transferring significant portions of 
its traditional ISD business and assets to such subsidiary; and issuing an 
equity interest in such subsidiary in exchange for certain proprietary assets 
necessary to pursue the Healthcare Opportunity. The completion of the 
formation of the subsidiary, the final negotiation with the other 
stockholder, the completion of permanent financing for the subsidiary and the 
start-up and commencement of operations of the Healthcare Opportunity will 
require substantial effort, the recruitment of management with experience in 
the demand management information services industry, and the expenditure of 
substantial funds. There can be no assurance that such efforts will come to 
fruition or that if completed, will result in a successful operation.

Future Capital Needs; Uncertainty of Additional Funding. In order to complete 
the research and development and other activities necessary to commercialize 
the Company's BioTech products, to start-up and continue to fund the 
Healthcare Opportunity and to fund the balance of the traditional ISD 
business, additional financing may be required. The Company's capital 
requirements depend on numerous factors, including without limitation the 
progress of its research and development programs, the progress of 
preclinical and clinical testing, the time and costs involved in obtaining 
regulatory approvals, the costs of filing, prosecuting, defending and 
enforcing any patent claims and other intellectual property rights, competing 
technological and market developments, changes in the Company's existing 
research relationships, the ability of the Company to establish collaborative 
arrangements, the development of commercialization activities and 
arrangements, and the purchase of capital equipment. There can be no 
assurance that the Company will obtain any or all such necessary funding.

Competition and Technological Change. The information systems industry is 
subject to rapid and significant technological change. Competitors of the 
Company are numerous and include, among others, major pharmaceutical, 
chemical, consumer, and biotechnology companies, specialized firms, 
universities and other research institutions. There can be no assurance that 
the Company's competitors will not succeed in developing technologies and 
products that are more effective than any which are being developed by the 
Company or that would render the Company's technology and potential products 
obsolete and noncompetitive. Many of these competitors have substantially 
greater financial and technical resources and production and marketing 
capabilities than the Company. The Company may seek any required additional 
funding through equity offerings, private financings and collaborative or 
other arrangements with third parties. There can be no assurance that 
additional funds will be available on acceptable terms. If additional funds 
are raised by issuing equity securities, further substantial dilution to 
existing shareholders may result. If adequate funds are not available, the 
Company may be required to delay, scale back or eliminate one or more of its 
research and development programs, or to obtain funds through entering into 
arrangements with third parties that may require the 

                                       10

<PAGE>


Company to relinquish rights to certain of its technologies or potential
products that the Company would not otherwise relinquish.

Government Regulation and Product Approvals. With respect to products 
developed by the BioTech unit, research, testing, manufacture, labeling, 
distribution, marketing and advertising of products are subject to extensive 
regulation by governmental regulatory authorities in the United States and 
other countries. The rigorous regulatory approval processes of the U.S. Food 
and Drug Administration (FDA) in the United States and of certain foreign 
regulatory authorities can take five to ten years or more and require the 
expenditure of substantial resources. There can be no assurance that the 
Company will be able to obtain the necessary approvals for clinical testing 
or for the marketing of products. Moreover, additional government regulations 
may be established that could prevent or delay regulatory approval of the 
Company's products. Delays in obtaining regulatory approvals could have a 
material adverse effect on the Company. Even if regulatory approval of a 
product is granted, such approval may include significant limitations on the 
indicated uses of the product or the manner in which or conditions under 
which the product may be marketed. Any sales of the Company's products 
outside the United States will be subject to regulatory requirements 
governing clinical trials and marketing approval. These requirements vary 
widely from country to country and could delay introduction of the Company's 
products in some countries. To the Company's knowledge, there is no current 
government regulation of the services expected to be provided via the 
Healthcare Opportunity. However, there can be no assurance that such 
regulation will not be initiated. In such an event, the costs and other 
requirements of such regulation could be prohibitive and may adversely affect 
the Company's pursuit of the Healthcare Opportunity.

Patents and Proprietary Technology. The Company's success depends, in part, 
on its ability to obtain and maintain patent protection for its BioTech 
products and methods, both in the United States and in other countries No 
assurance can be given that any additional patents will be issued to the 
Company, that the protection of any patents that may be issued in the future 
will be significant, or that current or future patents will be held valid if 
subsequently challenged.

Dependence Upon Key Employees. The success of the Company is dependent upon 
the efforts of its senior management team, including Gilbert V. Levin, Karen 
M. Levin, Richard C. Levin and Jeffrey W. Church. A change in the association 
of these individuals or other officers and directors of the Company could 
adversely affect the Company if suitable replacement personnel could not be 
employed. The success of the Company also depends upon its ability to 
continue to attract and retain qualified technical personnel. There is 
intense competition for qualified personnel in the areas of the Company's 
activities, and there can be no assurance that the Company will be able to 
continue to attract and retain the qualified personnel necessary for the 
development or expansion of its business.

Anti-Takeover Provisions. Certain provisions of the Company's Amended and 
Restated Articles of Incorporation, as well as aspects of certain stock 
options granted to Gilbert V. Levin and Karen M. Levin, could discourage a 
third party from attempting to acquire, or make it more difficult for a third 
party to acquire, control of the Company without approval of the Company's 
Board of Directors. Such provisions could also limit the price that certain 
investors might be willing to pay in the future for shares of the Common 
Stock. Certain of such provisions allow the Board of Directors to authorize 
the issuance of Preferred Stock with rights superior to those of the Common 
Stock.

                                       11

<PAGE>


Volatility of Stock Price and Earnings. The stock market has from time to 
time experienced significant price and volume fluctuations that may be 
unrelated to the operating performance of particular companies. In addition, 
the market price of the Common Stock has on occasion been, and may prove to 
continue to be, highly volatile. Announcements of technological innovations 
or new commercial products by the Company or its competitors, developments or 
disputes concerning patent or proprietary rights, publicity regarding actual 
or potential results relating to products under development by the Company or 
its competitors, regulatory developments in both the United States and 
foreign countries, sales of a large number of shares of Common Stock in the 
market, and economic and other external factors, as well as period-to-period 
fluctuations in financial results, among other factors, may have a 
significant impact on the market price of the Common Stock. In addition, the 
company has experienced substantial fluctuations in earnings from period to 
period. There can be no assurances that this trend will not continue due to 
the nature of the Company's business.

Potential for Dilution. As of January 21, 1998, "Warrants" to purchase 
870,000 shares of Common Stock issued in connection with the Private 
Placement and exercisable over the next three years at prices of $4.00 and 
$4.50 (as may be adjusted from time to time under certain antidilution 
provisions) were outstanding. The shares of Common Stock issuable upon 
exercise of these Warrants are being registered pursuant to this Registration 
Statement. The Warrants are not registered and may be sold only if registered 
under the Securities Act or sold in accordance with an applicable exemption 
from registration, such as Rule 144.

         As of January 21, 1998, 870,000 shares of Common Stock were reserved 
for issuance upon exercise of the Warrants. At December 31, 1997, there were 
8,829,190 shares of Common Stock outstanding. Of these outstanding shares, 
8,079,190 were freely tradeable without restriction under the Securities Act 
unless held by affiliates.

                                 USE OF PROCEEDS

The Company will not receive any proceeds from the sale of Common Stock by 
the Selling Shareholders. If any of the Warrants are exercised, the Company 
will receive the proceeds from such exercise and intends to use such proceeds 
for general working capital purposes.

                              SELLING SHAREHOLDERS

         The Shares were issued in one or more private placement transactions 
to the Selling Shareholders. The following table sets forth certain 
information with respect to the Selling Shareholders as of January 21, 1998, 
as follows: (i) the name and position or other relationship with the Company 
within the past three years of each Selling Shareholder; (ii) the number of 
the Company's outstanding shares of Common Stock beneficially owned by each 
Selling Shareholder (including shares obtainable under options exercisable 
within sixty (60) days of such date) prior to the offering hereby; (iii) the 
number of shares of Common Stock being offered hereby; and (iv) the number of 
and percentage of the Company's outstanding shares of Common Stock to be 
beneficially owned by each Selling Shareholder after completion of the sale 
of Common Stock being offered hereby. There is no assurance that any of the 
Selling Shareholders will sell any or all of the Shares offered hereby.

                                       12

<PAGE>

<TABLE>
<CAPTION>
                                Shares Beneficially
                                  Owned at January
                                  21, 1998 (1) (2)     Number of Shares   Shares Beneficially Owned After Offering
  Name of Selling Shareholder                           Being Offered            Number               Percent
- --------------------------------------------------------------------------------------------------------------------
<S>                                   <C>                   <C>                    <C>                  <C>
RCG International                     1,500,000             1,500,000              0                    0
Investors, LDC (3)

Wharton Capital                          60,000                60,000              0                    0
Partners, Ltd.

Francis F. Bodkin, Jr.                   30,000                30,000              0                    0

Mark Germain                             20,100                20,100              0                    0

Sanford Zweifach                          9,900                 9,900              0                    0

TOTAL                                 1,620,000             1,620,000              0                    0
</TABLE>

(1)      Except as otherwise noted, the information contained in the table above
         reflects "beneficial" ownership of the Common Stock within the meaning
         of Rule 13d-3 under the Exchange Act. On December 31, 1997, the Company
         had 8,829,190 shares of Common Stock outstanding.

(2)      The number of shares set forth in the table represents an estimate of
         the number of shares of Common Stock to be offered by the Selling
         Shareholders. The actual number of shares of Common Stock issuable upon
         exercise of the Warrants is indeterminate, is subject to adjustment and
         could be materially less or more than such estimated number depending
         on factors which cannot be predicted by the Company at this time. The
         actual number of shares of Common Stock offered hereby, and included in
         the Registration Statement of which this Prospectus is a part, includes
         such additional number of shares of Common Stock as may be issued or
         issuable upon exercise of the Warrants by reason of the adjustment
         mechanisms described therein, or by reason of any stock split, stock
         dividend or similar transaction involving the Common Stock, in order to
         prevent dilution, in accordance with Rule 416 under the Securities Act.

(3)      Pursuant to the terms of the Private Placement Warrants, the Private
         Placement Warrants are exercisable by any holder only to the extent
         that the number of shares of Common Stock thereby issuable, together
         with the number of shares of Common Stock owned by such holder and its
         affiliates (but not including shares of Common Stock underlying any
         unexercised portion of the Private Placement Warrants) would not exceed
         9.9% of the then outstanding Common Stock as determined in accordance
         with Section 13(a) of the Exchange Act. Accordingly, the number of
         shares of Common Stock set forth in the table for this Selling
         Shareholder exceeds the number of shares of Common Stock that this
         Selling Shareholder could own beneficially at any given time through
         its ownership of the Private Placement Warrants. In that regard,
         beneficial ownership of this Selling Shareholder set forth in the table
         is not determined in accordance with Rule 13d-3 under the Exchange Act.


                                       13

<PAGE>


                          DESCRIPTION OF CAPITAL STOCK

The Company's authorized capital stock consists of 18,000,000 shares of 
Common Stock, $.005 par value, and 2,000,000 shares of Preferred Stock, $.01 
par value. As of December 31, 1997, there were 8,829,190 shares of Common 
Stock outstanding and no shares of Preferred Stock outstanding.

The holders of Common Stock of the Company are entitled to receive pro rata 
dividends when and as declared by the Board of Directors in its discretion 
out of funds legally available therefor. In the event of the dissolution of 
the Company, whether voluntary or involuntary, the holders of Common Stock 
are entitled to share ratably in the assets of the Company legally available 
for distribution to its shareholders after the payment of the liquidation 
preference of any outstanding Preferred Stock. The holders of Common Stock 
have no preemptive, subscription, conversion or redemption rights, and are 
not subject to further calls or assessments by the Company. The Common Stock 
currently outstanding is, and the Common Stock issued in this offering will 
be, validly issued, fully paid and nonassessable.

Except as otherwise provided in the charter of the Company or required by 
law, the holders of shares of Common Stock are entitled to one vote per share 
on all matters to be voted on by shareholders and do not have the right of 
cumulative voting in connection with elections for directors, which means the 
holders of more than half the outstanding shares of Common Stock can elect 
all of the directors of the Company.

The Company is also authorized to issue 2,000,000 shares of Preferred Stock. 
The Company's Board of Directors is authorized to issue the Preferred Stock 
in one or more series and, with respect to each series, to determine the 
preferences and rights and the qualifications, limitations, or restrictions 
thereof, including the dividend rights, conversion rights, voting rights, 
redemption rights and terms, liquidation preferences, sinking fund 
provisions, the number of shares constituting each series and the designation 
of such series. The Board of Directors could, without shareholder approval, 
issue Preferred Stock with voting and other rights that could adversely 
affect the voting rights of the holders of the Common Stock.

One of the effects of the Preferred Stock may be to enable the Board of 
Directors to render more difficult or to discourage an attempt to obtain 
control of the Company by means of a merger, tender offer, proxy contest or 
otherwise, and thereby to protect the continuity of the Company's management.

                              PLAN OF DISTRIBUTION

The Shares covered hereby may be offered and sold from time to time by the 
Selling Shareholders for their respective pledgees, donees, transferees or 
other successors in interest. The Selling Shareholders will act independently 
of the Company in making decisions concerning sales or other dispositions of 
any Shares, and will act independently of the Company in making decisions 
with respect to the timing, manner and size of each sale. Such sales may be 
made in one or more transactions (which may involve block transactions) on 
the NASDAQ National Market System or otherwise, at prices and on terms then 
prevailing or at prices related to the then market price, in negotiated 
transactions, through the writing of options on the Shares, in short sales or 
any combination thereof. In addition, any Shares offered hereby which qualify 
for sale 

                                       14

<PAGE>

pursuant to Rule 144 under the Securities Act or any other exemption may be 
sold under Rule 144 or an other exemption rather than pursuant to this 
Prospectus.

The Shares may also be sold by one or more of the following methods: (a) a 
block trade in which the broker-dealer engaged by the Selling Shareholders 
will attempt to sell the shares as agent but may position and resell a 
portion of the block as principal to facilitate the transaction; (b) 
purchases by the broker-dealer as principal and resale by such broker or 
dealer for its account pursuant to this Prospectus; (c) ordinary brokerage 
transactions and transactions in which the broker solicits purchasers; and 
(d) underwritten public offerings. In effecting sales, broker-dealers engaged 
by the Selling Shareholders may arrange for other broker-dealers to 
participate. Broker-dealers may receive commissions or discounts from the 
Selling Shareholders in amounts to be negotiated.

In offering their Shares, the Selling Shareholders and any broker-dealers who 
execute sales for the Selling Shareholders may be deemed to be "underwriters" 
within the meaning of the Securities Act in connection with such sales, and 
any profits realized by the Selling Shareholders and the compensation of such 
broker-dealer may be deemed to be underwriting discounts and commissions.

This offering will terminate as to each Selling Shareholder on the earlier of 
(a) the date on which such Selling Shareholder's shares may be resold without 
volume restrictions under the Securities Act; or (b) the date on which all 
Shares offered hereby have been sold by the Selling Shareholders. There can 
be no assurance that any of the Selling Shareholders will sell any or all of 
the shares of Common Stock offered hereby.

                                  LEGAL MATTERS

The validity of the issuance of the shares of Common Stock offered hereby 
will be passed upon for the Company by Baxter, Baker, Sidle & Conn, P.A., 120 
E. Baltimore Street, Suite 2100, Baltimore, Maryland 21202.

                                     EXPERTS

The financial statements of Biospherics Incorporated appearing in Biospherics 
Incorporated's Annual Report on Form 10-KSB as of and for the year ended 
December 31, 1997, have been audited by Coopers & Lybrand L.L.P., independent 
accountants, as set forth in their report thereon incorporated herein by 
reference. Such financial statements are incorporated herein by reference in 
reliance upon such report given upon the authority of such firm as experts in 
accounting and auditing.

Any financial statements and schedules hereafter incorporated by reference in 
the registration statement of which this prospectus is a part that have been 
audited and are the subject of a report by independent accountants will be so 
incorporated by reference in reliance upon such reports and upon the 
authority of such firms as experts in accounting and auditing to the extent 
covered by consents filed with the Commission.

No dealer, salesperson or other person has been authorized to give any 
information or to make any representation not contained in this Prospectus 
and, if given or made, such information or 

                                       15

<PAGE>


representation must not be relied upon as having been authorized by the 
Company. This Prospectus does not constitute an offer to sell or a 
solicitation of an offer to buy any of the securities offered hereby in any 
jurisdiction to any person to whom it is unlawful to make such offer or 
solicitation in such jurisdiction. Neither the delivery of this Prospectus 
nor any sale made hereunder shall, under any circumstances, create any 
implication that the information herein is correct as of any time subsequent 
to the date hereof or that there has been no change in the affairs of the 
Company since such date.

                                TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                Page
<S>                                                               <C>
Available Information...........................................  3
Incorporation of Certain Documents by Reference.................  4
Forward Looking Statements......................................  5
The Company.....................................................  5
Risk Factors....................................................  9
Use of Proceeds.................................................  12
Selling Shareholders............................................  12
Description of Capital Stock....................................  14
Plan of Distribution............................................  14
Legal Matters...................................................  15
Experts.........................................................  15
</TABLE>

                               1,620,000 Shares of
                                  Common Stock

                                 March 23, 1998

                                   PROSPECTUS


                                       16

<PAGE>


                                      
                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS


ITEM 14.  Other Expenses of Issuance and Distribution.

The following table sets forth the costs and expenses to be paid in connection
with the sale of the shares of Common Stock being registered hereby, all of
which will be paid by the Registrant. All amounts are estimates except for the
Securities and Exchange Commission registration fee.

<TABLE>
<S>                                                             <C>
Securities and Exchange Commission registration fee             $2,121

NASDAQ National Market System filing fee                        15,000

Accounting fees and expenses                                     1,500

Legal fees and expenses                                         10,000

Printing and miscellaneous                                       1,000
                                                               -------
Total                                                          $29,621
                                                               -------
                                                               -------
</TABLE>


ITEM 15.  Indemnification of Directors and Officers.

Section 145 of the Delaware General Corporation Law permits the Registrant to 
indemnify directors, officers, employees and agents of the Registrant against 
actual and reasonable expenses (including attorneys' fees) incurred by them 
in connection with any action, suit or proceeding brought against them by 
reason of their status or service as a director, officer, employee or agent 
by or on behalf of the Registrant, and against expenses (including attorneys' 
fees), judgments, fines and settlements actually and reasonably incurred in 
connection with any such action, suit or proceeding, if (i) he or she acted 
in good faith and in a manner he or she reasonably believed to be in or not 
opposed to the best interests of the Registrant, and (ii) in the case of a 
criminal proceeding, he or she had no reasonable cause to believe his or her 
conduct was unlawful. Except as ordered by a court, no indemnification shall 
be made in connection with any proceeding brought by or in the right of the 
corporation where the person involved is adjudged to be liable to the 
Registrant.

Article IV of the Registrant's By-Laws provides that the Registrant shall, to 
the fullest extent permitted by the General Corporation Law of the State of 
Delaware, as amended from time to time, indemnify each person who was or is a 
party or is threatened to be made a party to any threatened, pending or 
completed action, suit or proceeding whether civil, criminal, administrative 
or investigative, by reason of the fact that he or she is or was, or has 
agreed to become a director or officer of the Registrant, or is or was 
serving, or has agreed to serve at the request of the Registrant as a 
director, officer or trustee of, or in a similar capacity with, another 
corporation, partnership, joint venture, trust or other enterprise. The 
indemnification provided for in Article IV is expressly not exclusive of any 
of the rights to which those seeking


                                      II-1
<PAGE>

indemnification may be entitled under any law, agreement or vote of 
stockholders or disinterested directors or otherwise, and shall inure to the 
benefit of the heirs, executors and administrators of such persons.

Article TENTH of the Registrant's Restated Certificate of Incorporation 
provides that a director shall not be personally liable to the Registrant or 
its stockholders for monetary damages for breach of fiduciary duty as a 
director, except to the extent that elimination or limitation of liability is 
not permitted under the Delaware General Corporation Law as in effect when 
such liability is determined.

The Registrant also maintains a Directors and Officers Liability Policy.


ITEM 16.  Exhibits.

The following exhibits are filed herewith or incorporated by reference herein:

Exhibit
Number                        Exhibit Title
- -------                       -------------
<TABLE>
<S>    <C>
4.1    Amended and Restated Articles of Incorporation of the Company.
         (Incorporated by reference to the Company's Annual Proxy Statement of
         May 15, 1992, File No. 0-5576)

4.2    Bylaws of the Company. (Incorporated by reference to the Company's
         Annual Proxy Statement of May 15, 1992, File No. 0-5576)

4.3    Specimen Common Stock Certificate. (Incorporated by reference to the
         Company's Annual Proxy Statement of May 15, 1992, File No. 0-5576)

4.4    Securities Purchase Agreement dated as of December 12, 1997, by and
         between the Company and RCG International Investors, LDC (Incorporated
         by reference to the Company's Form 8-K filed on December 18, 1997, File
         No. 0-5576)

5.1    Opinion of Baxter, Baker, Sidle & Conn, P.A.

23.1   Consent of Coopers & Lybrand L.L.P.

23.2   Consent of Baxter, Baker, Sidle & Conn, P.A. (included in Exhibit 5.1)

24.1   Power of Attorney (See signature page).
</TABLE>

ITEM 17.  Undertakings.

Insofar as indemnification for liabilities arising under the Securities Act 
may be permitted to directors, officers and controlling persons of the 
Registrant pursuant to the provisions described under Item 15 above, or 
otherwise, the Registrant has been advised that in the opinion of the 
Securities and Exchange Commission such indemnification is against public 
policy as expressed in the Securities Act and is, therefore, unenforceable. 
In the event that a claim for indemnification against such liabilities (other 
than the payment by the Registrant of expenses incurred or paid by a 
director, officer or controlling person of the Registrant in the successful 
defense of any action, suit or proceeding) is asserted by such director, 
officer or controlling person in connection with the securities being 
registered, the Registrant will, unless in the opinion of its counsel the 
matter has been settled by controlling precedent, submit to a court of 

                                      II-2

<PAGE>

appropriate jurisdiction the question whether such indemnification by it is 
against public policy as expressed in the Securities Act and will be governed 
by the final adjudication of such issue.

The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
         a post-effective amendment to this Registration Statement: (i) to
         include any prospectus required by Section 10(a)(3) of the Securities
         Act; (ii) to reflect in the prospectus any facts or events arising
         after the effective date of the Registration Statement (or the most
         recent post-effective amendment thereof) which, individually or in the
         aggregate, represent a fundamental change in the information in the
         Registration Statement; and (iii) to include any material information
         with respect to the plan of distribution not previously disclosed in
         the Registration Statement or any material change to such information
         in the Registration Statement; provided, however, that (i) and (ii) do
         not apply if the information required to be included in a
         post-effective amendment thereby is contained in periodic reports filed
         by the Registrant pursuant to Section 13 or Section 15(d) of the
         Exchange Act that are incorporated by reference in the Registration
         Statement.

         (2) That, for the purpose of determining any liability under the
         Securities Act, each post-effective amendment shall be deemed a new
         registration statement relating to the securities offered therein, and
         the offering of the securities at that time shall be deemed to be the
         initial bona fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
         any of the securities being registered that remain unsold at the
         termination of the offering.

         (4) That, for purposes of determining any liability under the
         Securities Act, each filing of the Registrant's annual report pursuant
         to Section 13(a) or Section 15(d) of the Exchange Act that is
         incorporated by reference in this Registration Statement shall be
         deemed to be a new Registration Statement relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof.

                                   SIGNATURES

In accordance with the requirements of the Securities Act of 1933, the 
registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-3 and authorized this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of Beltsville, State of Maryland, on 
March 23, 1998.

                            BIOSPHERICS INCORPORATED

                            By: /s/ Gilbert V. Levin

                                Gilbert V. Levin,
                      President and Chief Executive Officer


                                      II-3

<PAGE>



                        Baxter, Baker, Sidle & Conn, P.A.
                                Attorneys at Law
                       120 E. Baltimore Street, Suite 2100
                         Baltimore, Maryland 21202-1643

James E. Baker, Jr.                             Telephone (410) 230-3800
Direct Line (410) 385-8122                      Facsimile (410) 230-3801
e-mail: [email protected]

                                                 EXHIBIT 5.1


                                January 21, 1998



Biospherics Incorporated
12051 Indian Creek Court
Beltsville, MD 20705

Ladies and Gentlemen:

         We have acted as counsel to Biospherics Incorporated, a Delaware
corporation (the "Company"), in connection with the registration under the
Securities Act of 1933, of 1,620,000 shares of Common Stock of the Company,
$.005 par value per share, pursuant to a Registration Statement on Form S-3 to
be filed with the Securities and Exchange Commission (the "Registration
Statement").

         In rendering the opinions contained herein, we have examined originals
or photostatic or certified copies of all certificates, documents, agreements
and other instruments as we have deemed appropriate.

         Based upon the foregoing, we are of the opinion that each of the
1,620,000 shares of the Common Stock of the Company covered by the Registration
Statement, when issued by the Company in accordance with the Securities Purchase
Agreement and accompanying Stock Purchase Warrants dated as of December 12,
1997, and for not less than the par value thereof, will be duly authorized,
validly issued, fully paid and nonassessable.




<PAGE>


Biospherics Incorporated
January 21, 1998
Page 2



         This opinion is furnished by us solely for the benefit of the Company
in connection with the filing of the Registration Statement. We consent to the
use of this opinion as an exhibit to the Registration Statement.

                                Very truly yours,

                                Baxter, Baker, Sidle & Conn, P.A.


                                By:   /s/ James E. Baker, Jr.
                                     -----------------------------------
                                     James E. Baker, Jr., Vice President





<PAGE>


                                                                  EXHIBIT 23.1



                       CONSENT OF INDEPENDENT ACCOUNTANTS

We consent to the incorporation by reference in this registration statement 
on Form S-3 of our report dated February 20, 1998, on our audits of the 
financial statements of Biospherics Incorporated as of December 31, 1997 and 
for each of the two years in the period ended December 31, 1997, appearing in 
the Biospherics Incorporated Annual Report on Form 10-KSB filed with the 
Securities and Exchange Commission pursuant to the Securities Act of 1934. We 
also consent to the references to our firm under the caption "Experts."


                                                      Coopers & Lybrand L.L.P.

Baltimore, Maryland
March 23, 1998



<PAGE>


                                                                  EXHIBIT 24.1



                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS that each individual whose signature appears 
below constitutes and appoints Gilbert V. Levin and M. Karen Levin and each 
of them, his or her true and lawful attorneys-in-fact and agents with full 
power of substitution, for him or her and in his or her name, place and 
stead, in any and all capacities, to sign any and all amendments (including 
post-effective amendments) to this Registration Statement on Form S-3, and to 
file the same with all exhibits thereto and all documents in connection 
therewith, with the Securities and Exchange Commission, granting unto said 
attorneys-in-fact and agents, and each of them, full power and authority to 
do and perform each and every act and thing requisite and necessary to be 
done in and about the premises, as fully to all intents and purposes as he 
might or could do in person, hereby ratifying and confirming all of said 
attorneys-in-fact and agents, or any of them, or his or their substitute or 
substitutes, may lawfully do or cause to be done by virtue hereof.

In accordance with the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the dates stated.

<TABLE>
<CAPTION>
                 Name                           Title                         Date
- ------------------------------- -------------------------------------- -----------------
<S>                            <C>                                      <C>
 /s/ Gilbert V. Levin           President, Chief Executive Officer
- ----------------------          and Director                            January 22, 1998
Gilbert V. Levin


 /s/ Jeffrey W. Church          Executive Vice President,
- ----------------------          Principal Financial Officer,
Jeffrey W. Church               Principal Accounting Officer
                                and Chief Financial Officer             January 22, 1998

Directors:

 /s/ M. Karen Levin             Director                                January 22, 1998
- -------------------
M. Karen Levin

 /s/ Dr. David A. Blake         Director                                January 16, 1998
- -----------------------
Dr. David A. Blake

 /s/ Dr. Lionel V. Baldwin      Director                                January 16, 1998
- --------------------------
Dr. Lionel V. Baldwin

 /s/ A. Bruce Cleveland         Director                                January 21, 1998
- -----------------------
A. Bruce Cleveland
</TABLE>


<PAGE>

<TABLE>
<S>                             <C>                                     <C>
 /s/ Dr. Rita R. Colwell        Director                                January 14, 1998
- ------------------------
Dr. Rita R. Colwell

 /s/ George S. Jenkins          Director                                January 15, 1998
- ----------------------
George S. Jenkins


 /s/ Dr. Anne S. MacLeod        Director                               January 21, 1998
- ------------------------
Dr. Anne S. MacLeod
</TABLE>


The Company has agreed to pay for all costs and expenses incident to the 
issuance, offer, sale and delivery of the Shares, including, but not limited 
to, all expenses and fees of preparing, filing and printing the Registration 
Statement and Prospectus and related exhibits, amendments and supplements 
thereto and mailing of such items. The Company will not pay selling 
commissions and expenses associated with any such sales by the Shareholders. 
The Company has agreed to indemnify the Shareholders against civil 
liabilities under the Securities Act of 1933.



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