BRISTOL MYERS SQUIBB CO
S-3, 1995-07-20
PHARMACEUTICAL PREPARATIONS
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As filed with the Securities and Exchange Commission on July 20, 1995

                                                  Registration No. 33-
=============================================================================

                  SECURITIES AND EXCHANGE COMMISSION
                        WASHINGTON, D.C. 20549
                     ---------------------------

                               FORM S-3
                        REGISTRATION STATEMENT
                                UNDER
                      THE SECURITIES ACT OF 1933
                     ---------------------------

                     Bristol-Myers Squibb Company
        (Exact name of registrant as specified in its charter)
                               Delaware
                       (State of incorporation)
                             22-079-0350
                 (I.R.S. Employer Identification No.)
                           345 Park Avenue
                         New York, N.Y. 10154
                            (212) 546-4000
         (Address, including zip code, and telephone number,
  including area code, of registrant's principal executive offices)
                     ---------------------------

    John L. McGoldrick, Esq.                   Alice C. Brennan
    Senior Vice President and                  Vice President and
       General Counsel                         Corporate Secretary
                       Bristol-Myers Squibb Company
                           345 Park Avenue
                         New York, N.Y. 10154
                            (212) 546-4000
      (Name, address, including zip code, and telephone number,
              including area code, of agent for service)

                               Copy to:
                         Susan Webster, Esq.
                       Cravath, Swaine & Moore
                           Worldwide Plaza
                          825 Eighth Avenue
                         New York, N.Y. 10019
                            (212) 474-1000
                     ---------------------------

Approximate date of commencement of proposed sale to the public: From
time to time after the effective date of this registration statement.

     If the only securities being registered on this Form are being
offered pursuant to dividend or interest reinvestment plans, please
check the following box. [ ]

     If any of the securities being registered on this Form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under
the Securities Act of 1933, other than securities offered only in
connection with dividend or interest reinvestment plans, check the
following box. [X]

     If this Form is filed to register additional securities for an
offering pursuant to Rule 462(b) under the Securities Act, please
check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for
the same offering. [ ] 

     If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]  

     If delivery of the prospectus is expected to be made pursuant to
Rule 434, please check the following box. [ ]

                     ---------------------------

                   CALCULATION OF REGISTRATION FEE
============================================================================
                                      Proposed      Proposed     
   Title of                           Maximum        Maximum
 Each Class of     Amount             Offering      Aggregate      Amount       
 Securities to     to be               Price         Offering    Registration
 be Registered   Registered          Per Share*       Price*        Fee
- ----------------------------------------------------------------------------
Common Stock, 
par value $.10
per share ..... 2,500,000 shares    $68.625**    $171,562,500    $59,159.48
============================================================================

*    Estimated solely for the purpose of calculating the registration fee.
**   Calculated in accordance with Rule 457(c) under the Securities Act 
     based upon the high and low price of securities of the same class on 
     July 17, 1995, as quoted per the New York Stock Exchange Composite Tape.

                     ---------------------------

     The registrant hereby amends this registration statement on such
date or dates as may be necessary to delay its effective date until
the registrant shall file a further amendment which specifically
states that this registration statement shall thereafter become
effective in accordance with Section 8(a) of the Securities Act of
1933 or until the registration statement shall become effective on
such date as the Commission, acting pursuant to said Section 8(a), may
determine.
=============================================================================




<PAGE>


PROSPECTUS

                     BRISTOL-MYERS SQUIBB COMPANY

                   2,500,000 Shares of Common Stock
                       Par Value $.10 per Share

          This Prospectus relates to 2,500,000 shares of Common Stock,
par value $.10 per share (the "Securities") of Bristol-Myers Squibb
Company, a Delaware corporation (the "Company"), issued to the
shareholders named herein under the caption "Selling Shareholders"
(the "Selling Shareholders") in connection with the acquisition by the
Company of Matrix Essentials, Inc., which Securities are being offered
for sale pursuant hereto for the account of such Selling Shareholders.
This Prospectus is to be used in connection with the sale from time to
time by the Selling Shareholders of the Securities.

          The Company has agreed with the Selling Shareholders to
register the Securities offered hereby. The Company has also agreed to
pay certain fees and expenses incident to such registration, including
certain fees and expenses of any attorneys and accountants employed by
the Selling Shareholders and certain other costs directly incurred by
the Selling Shareholders in connection with the offering of the
Securities pursuant hereto. It is estimated that the fees and expenses
payable by the Company in connection with the registration of the
Securities will be approximately $155,000. The Company intends to keep
the registration statement, of which this Prospectus is a part,
effective for a period of no longer than 90 days from the date of this
Prospectus.

          The Common Stock of the Company is listed on the New York
Stock Exchange and the Pacific Stock Exchange. On July 17, 1995 the
last sale price on the New York Stock Exchange for one share of Common
Stock of the Company was $68.625.

          The Selling Shareholders, their donees or estates, and their
respective pledgees and dealers who may purchase from the foregoing,
may from time to time sell all or part of the Securities that may be
offered by such person hereunder on the New York Stock Exchange, the
Pacific Stock Exchange or other securities exchange or over the
counter market, at prices and at terms then prevailing or in
negotiated transactions or otherwise. The price at which any of the
shares of Common Stock may be sold, and the commissions, if any, paid
in connection with any sale, are unknown and may vary from transaction
to transaction. See "Plan of Distribution" below. It is understood
that the Securities and Exchange Commission (the "Commission") may
take the view that, under certain circumstances, such persons
effecting resales of Securities purchased and dealers or brokers
handling such transactions may be deemed (such persons not so
conceding) to be "underwriters" within the meaning of the Securities
Act of 1933, and the rules and regulations promulgated thereunder (the
"Securities Act"), with respect to such sales.

                     ---------------------------


THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
  AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS
THE SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION 
       PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
      ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

                     ---------------------------


                The date of this Prospectus is , 1995.



<PAGE>

          No person has been authorized to give any information or to
make any representations not contained in this Prospectus in
connection with the offer made by this Prospectus and, if given or
made, such information or representations must not be relied upon as
having been authorized by the Company or by any underwriter, dealer or
agent. This Prospectus does not constitute an offer to sell or a
solicitation of an offer to buy any of the Securities offered hereby
in any jurisdiction to any person to whom it is unlawful to make such
offer or solicitation in such jurisdiction. This Prospectus does not
constitute an offer to sell or a solicitation of an offer to buy any
securities other than those to which it relates. Neither the delivery
of this Prospectus nor any sale of or offer to sell the Securities
offered hereby shall, under any circumstances, create an implication
that there has been no change in the affairs of the Company since the
date hereof or that the information herein is correct as of any time
subsequent to its date.

                        AVAILABLE INFORMATION

          The Company is subject to the informational requirements of
the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
and in accordance therewith files reports, proxy statements and other
information with the Commission. Such reports, proxy statements and
other information filed by the Company with the Commission pursuant to
the informational requirements of the Exchange Act can be inspected
and copied at the public reference facilities maintained by the
Commission at Room 1024, Judiciary Plaza, 450 Fifth Street, N.W.,
Washington, D.C. 20549, and at the following Regional Offices of the
Commission: New York Regional Office, 7 World Trade Center, 13th
Floor, New York, New York 10048 and Chicago Regional Office, Citicorp
Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661.
Copies of such material can also be obtained upon written request
addressed to the Securities and Exchange Commission, Public Reference
Section, Room 1024, 450 Fifth Street, N.W., Washington, D.C. 20549 at
prescribed rates. Such reports, proxy statements and other information
can also be inspected at the offices of the New York Stock Exchange,
20 Broad Street, New York, New York 10005, and at the offices of the
Pacific Stock Exchange, 301 Pine Street, San Francisco, California
94104, on which certain of the Company's securities are listed.

          This Prospectus forms a part of a registration statement on
Form S-3 (referred to herein, including all amendments and exhibits,
as the "Registration Statement") which the Company has filed under the
Securities Act with respect to the Securities. This Prospectus does
not contain all the information otherwise set forth in the
Registration Statement, certain parts of which are omitted in
accordance with the rules and regulations of the Commission. For
further information, reference is made to the Registration Statement
and the exhibits filed as part thereof. The Registration Statement may
be inspected at the public reference facilities maintained by the
Commission at the addresses set forth in the preceding paragraph.
Statements contained herein concerning any document filed as an
exhibit are not necessarily complete and, in each instance, reference
is made to the copy of such document filed as an exhibit to the
Registration Statement. Each such statement is qualified in its
entirety by such reference.

                 DOCUMENTS INCORPORATED BY REFERENCE


          The Company hereby incorporates by reference (i) its Annual
Report on Form 10-K for the fiscal year ended December 31, 1994, (ii)
its Quarterly Report on Form 10-Q for the three months ended March 31,
1995; (iii) its Current Report on Form 8-K filed with the Commission
on May 1, 1995; (iv) its Current Report on Form 8-K filed with the
Commission on June 16, 1995, (v) the description of the Common Stock
contained in the registration statement filed under the Exchange Act,
including any amendment or reports filed for the purpose of updating
such description, (vi) the description of the Rights to Purchase
Preferred Stock contained in the Registration Statement on the
Company's Form 8-A dated December 10, 1987 and the Company's Form 8
dated July 27, 1989 and (vii) its Proxy Statement and Notice of Annual
Meeting of Stockholders for the annual meeting held on May 2, 1995,
each of which has been filed with the Commission pursuant to the
requirements of the Exchange Act.




<PAGE>


          All documents filed by the Company pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof
and prior to the termination of the offering of the Securities offered
hereby shall be deemed to be incorporated by reference herein and to
be a part hereof from the date of filing of such documents.

          Any statement contained in a document incorporated or deemed
to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Prospectus to the extent that a
statement contained herein or in any other subsequently filed document
that also is or is deemed to be incorporated by reference herein
modifies or supersedes such statement. Any such statement so modified
or superseded shall not be deemed, except as so modified or
superseded, to constitute a part of this Prospectus.

          The Company will furnish without charge to each person,
including any beneficial owner, to whom this Prospectus is delivered,
upon written or oral request of such person, a copy of any and all
documents incorporated herein by reference (not including exhibits to
such documents, unless such exhibits are specifically incorporated by
reference into such documents). Requests should be directed to
Bristol-Myers Squibb Company, 345 Park Avenue, New York, New York
10154, Attention: Corporate Secretary (telephone number: (212)
546-3309).


                     BRISTOL-MYERS SQUIBB COMPANY

          The Company is a world-wide organization engaged primarily
in the manufacture and sale of a broad range of pharmaceutical
products, medical devices, nonprescription health products, toiletries
and beauty aids. The Company's principal business segments are:

          Pharmaceutical Products, including prescription medicines,
          mainly cardiovascular, anti-infective and anti-cancer drugs,
          central nervous system drugs and other pharmaceutical
          products;

          Medical Devices, including orthopaedic implants, ostomy and
          wound care products, surgical instruments and other medical
          devices;

          Nonprescription Health Products, including infant formulas
          and other nutritional products, analgesics, cough/cold
          remedies and skin care products; and

          Toiletries and Beauty Aids, including haircoloring and hair
          care preparations, deodorants, anti-perspirants, toiletries
          and other beauty aids.

          All references herein to the Company include Bristol-Myers
Squibb Company and its subsidiaries, unless the context otherwise
requires.

          The principal executive offices of the Company are located
at 345 Park Avenue, New York, New York 10154. Its telephone number is
(212) 546-4000.




<PAGE>

                           USE OF PROCEEDS


          The Company will receive no proceeds from the sale of the
Securities. All proceeds from the sale of the Securities will be for
the account of the Selling Shareholders described below. See "Selling
Shareholders" and "Plan of Distribution" described below.


                     DESCRIPTION OF CAPITAL STOCK


Capital Stock

          The following statements with respect to the Company's
capital stock are subject to the detailed provisions of the Company's
Restated Certificate of Incorporation (the "Certificate of
Incorporation"), Bylaws, as amended (the "Bylaws") and the Rights
Agreement (defined below). These statements do not purport to be
complete and are qualified in their entirety by reference to the terms
of the Certificate of Incorporation, the Bylaws and the Rights
Agreement, each of which are incorporated by reference into this
Prospectus.

          The Company's authorized capital stock consists of 1.5
billion shares of common stock, par value $.10 per share (the "Common
Stock"), and 10 million shares of preferred stock. As of July 17,
1995, 506,335,297 shares of Common Stock were issued and outstanding
(excluding 32,979,618 shares held in treasury) and 19,871 shares of
Cumulative Convertible Preferred Stock of the Company, par value $1.00
per share (the "Convertible Preferred Stock") were issued and
outstanding.

Common Stock

          The holders of Common Stock are entitled to receive
dividends when and as declared by the Board of Directors of the
Company out of funds legally available therefor, subject to the terms
of any preferred stock of the Company at the time outstanding.

          The holders of Common Stock are entitled to one vote for
each share on all matters voted on by stockholders, including
elections of directors. The holders of the Common Stock do not have
any cumulative voting, conversion, redemption or preemptive rights. In
the event of dissolution, liquidation or winding up of the Company,
holders of the Common Stock will be entitled to share ratably,
together with any participating preferred stock of the Company, in any
assets remaining after the satisfaction in full of the prior rights of
creditors, including holders of indebtedness of the Company, and the
aggregate liquidation preference of any preferred stock of the Company
then outstanding.

          The outstanding shares of the Company Common Stock are
listed on the New York Stock Exchange and the Pacific Stock Exchange.
Chemical Bank, 450 West 33rd Street, New York, New York 10001 and
Chemical Trust Company of California, 50 California Street-10th Floor,
San Francisco, California 94111 are the transfer agents and registrars
for the Common Stock.

          The rights of the holders of Common Stock are subject to the
rights of the holders of the Convertible Preferred Stock described
below. Each share of Common Stock also carries with it an associated
Right to Purchase Preferred Stock, also described below.


<PAGE>


Cumulative Convertible Preferred Stock

          Dividend Rights. Holders of Convertible Preferred Stock are
entitled to receive, when and as declared by the Board of Directors of
the Company out of funds legally available for payment, annual
dividends in an amount per share equal to $2.00. Dividends on shares
of Convertible Preferred Stock are payable on the first day of March,
June, September and December of each year. Dividends on the
Convertible Preferred Stock are cumulative and accrue on a day-to-day
basis.

          For so long as the Convertible Preferred Stock is
outstanding, the Company may not declare or pay any dividend on Common
Stock or redeem or purchase any other preferred stock of the Company
or purchase Common Stock, unless full cumulative dividends on the
Convertible Preferred Stock have been paid or declared, and funds set
apart for payment thereof.

          Conversion Provisions. At the election of the holder
thereof, each share of Convertible Preferred Stock is convertible into
shares of Common Stock, subject to adjustment as set forth below. As
of the date of this Prospectus, each share of Convertible Preferred
Stock is convertible into 4.24 shares of Common Stock. With respect to
shares of Convertible Preferred Stock called for redemption,
conversion rights will expire at the close of business on the date
fixed for redemption, unless the Company defaults in the payment of
the redemption price.

          No fractional shares will be issued upon conversion, and, in
lieu thereof, an adjustment in cash will be made based upon the
closing price of Common Stock on the NYSE on the day of conversion.

          The conversion rate will be subject to adjustment in certain
events to preserve the relative rights of holders of Convertible
Preferred Stock, including certain subdivisions and combinations of
Common Stock, certain reclassifications, and certain consolidations
and mergers of the Company. Adjustments in the conversion rate will be
deferred until cumulative adjustments shall have resulted in a change
of the conversion rate by at least one one-hundredth of one share of
Common Stock. No payment or allowance will be made upon conversion in
respect of any accrued and unpaid dividends.

          Liquidation Rights. In the event of liquidation, dissolution
or winding up of the Company, whether voluntary or involuntary, the
holders of Convertible Preferred Stock then outstanding are entitled
to receive $50.00 per share plus all accrued and unpaid dividends.

          Redemption. The Convertible Preferred Stock is redeemable,
at the option of the Company, in whole or in part, at the price of
$50.00 per share together with accrued and unpaid dividends at the
date of redemption. If the Company shall redeem less than all of the
outstanding shares of the Convertible Preferred Stock, the Board of
Directors of the Company will determine the shares to be redeemed by
lot.

          Voting Rights. Each share of Convertible Preferred Stock
entitles the holder thereof to one vote per share and, except as
otherwise provided by the Certificate of Incorporation or as required
by law, the Convertible Preferred Stock and the Common Stock vote as
one class except that while holders of shares of Convertible Preferred
Stock voting as a class are entitled to elect two directors as
provided in the Certificate of Incorporation, such holders are not
entitled to participate with the Common Stock in the election of any
other directors.

          Without the affirmative vote of the holders of at least
two-thirds of the outstanding shares of Convertible Preferred Stock,
the Company may not amend, alter or repeal any provision of the
Certificate of Incorporation or Bylaws so as to materially affect any
of the powers, preferences and rights of Convertible Preferred Stock.
The holders of Convertible Preferred Stock have no other voting rights
except as may be required by law.



<PAGE>

Preferred Stock Purchase Rights

          Each share of Common Stock carries with it an associated
right (the "Right") that entitles holders of Common Stock to buy one
one-thousandth of a share of a new series of participating preferred
stock of the Company at an exercise price of $200 under certain
circumstances. The Rights separate from the associated shares of
Common Stock and become exercisable only after a person or group
acquires beneficial ownership of 20% or more of Common Stock or
commences a tender or exchange offer upon consummation of which such
person or group would beneficially own 30% or more of the Common
Stock.

          If any person (i) becomes the beneficial owner of 25% or
more of Common Stock, other than pursuant to certain tender or
exchange offers described in the rights agreement that governs the
Rights (the "Rights Agreement," a copy of which has been filed with
the Commission and is incorporated by reference herein), (ii) who is a
20% or more stockholder engages in certain self-dealing transactions
described in the Rights Agreement or (iii) engages in a merger
transaction with the Company in which the Company is the surviving
corporation and its shares of Common Stock are not changed or
converted, then each Right not owned by such person or related parties
will entitle its holder to purchase, at the Right's then-current
exercise price, shares of Common Stock (or, in certain circumstances
as determined by the Board, cash, property or other securities of the
Company) having a value of twice the Right's exercise price. In
addition, if the Company is involved in a merger or other business
combination transaction with another person in which its shares of
Common Stock are changed or converted, or sells 50% or more of its
assets or earning power to another person, each Right will entitle its
holder to purchase, at the Right's then- current exercise price,
common shares of such other person having a value of twice the Right's
exercise price.

          The Company is generally entitled to redeem the Rights at a
price of one cent per Right at any time until the 15th day following
public announcement that a 20% position has been acquired.

                         SELLING SHAREHOLDERS


          Each of the Selling Shareholders was formerly a shareholder
of Matrix Essentials, Inc., an Ohio corporation ("Matrix"). On August
5, 1994, Matrix and certain related businesses were acquired by the
Company and Matrix became a wholly-owned subsidiary of the Company.
The Securities offered hereby were acquired by the Selling
Shareholders as consideration for the acquisition of Matrix and such
related businesses by the Company.

          The following table sets forth as of July 17, 1995, the name
of each of the Selling Shareholders, the nature of his, her or its
position, office, or other material relationship to the Company or its
subsidiaries, if applicable, and the number of shares of Common Stock
which each such Selling Shareholder owned of record as of the date of
this Prospectus. The table also sets forth the number of shares of
Common Stock owned by each Selling Shareholder that are offered for
sale by this Prospectus and the number of shares of Common Stock to be
held by each such Selling Shareholder assuming the sale of all the
Securities offered hereby. The Company may supplement this Prospectus
from time to time to disclose the names, relationships to the Company
and holdings of Securities of additional Selling Shareholders. No
statement contained herein nor the delivery of this Prospectus in
connection with a sale by any Selling Shareholder shall be deemed an
admission by the Company or such Selling Shareholder that such Selling
Shareholder is in a control relationship with the Company within the
meaning of the Securities Act.




<PAGE>

                                                  Maximum
                                                  Number of      Number of
                                Number of         of Shares    Shares of Common
       Name and                 Shares of        to be Sold   Stock to be Held
      Relationship              Common Stock      Pursuant      Assuming Sale 
       to Company               Owned as of        to this    of all the Shares
        if any(1)               July 17, 1995     Offering(2)   Offered Hereby
- ----------------------------    -------------    -----------  -----------------

 1. Arnold M. Miller Included 
    Marital Trust f/b/o
    Sydell L. Miller u/a dtd 
    7/6/78.                      2,905,603         1,093,269      1,812,334

 2. Arnold M. Miller GST Exempt 
    Trust f/b/o Stacie Miller 
    Halpern u/a dtd 7/6/78.         71,233            23,936         47,297

 3. Arnold M. Miller GST Exempt 
    Trust f/b/o Lauren Miller 
    Spilman u/a dtd 7/6/78.         71,233            23,936         47,297

 4. Sydell L. Miller Dynasty 
    Trust f/b/o Stacie Miller 
    Halpern u/a dtd 8/26/93.     1,315,136           602,950        712,186

 5. Sydell L. Miller Dynasty 
    Trust f/b/o Lauren Miller 
    Spilman u/a dtd 8/26/93.     1,315,136           602,950        712,186  

 6. David A. Cook, Vice
    President of Matrix.(3)         73,672            24,698         48,929

 7. Jeffrey J. Kunz, Vice 
    President of Matrix.            73,672            24,698         48,929
   
 8. Dennis E. Lubin, Vice 
    President of Matrix.            73,627            24,740         48,887

 9. Robert G. Markey.(4)            73,627            24,740         48,887
  
10. D. Scott Miller, 
    Vice President of Matrix.       73,627            24,698         48,929

11. Robert C. Miller, Vice 
    President of Matrix.(5)         36,766            12,355         24,411
    
12. Sydell L. Miller, 
    Chairman of Matrix.             17,030            17.030              0
    
- ------------------------------
 (1) Except as otherwise noted, none of the Selling Shareholders has any 
     relationship with the Company other than as a shareholder.
 (2) In the event that certain Selling Shareholders elect not to dispose 
     of the maximum number of shares set forth opposite their names below 
     pursuant hereto, the amount not so disposed of may be used by the 
     remaining Selling Shareholders to increase on a pro rata basis the 
     maximum number of Shares that may be sold by each of them; provided, 
     however, that in no event will the total number of Shares offered 
     hereby exceed 2,500,000.
 (3) Up to 1,200 of the shares to be sold by or for the benefit of Mr. Cook 
     may be sold by Maxus Foundation and up to an additional 10,000 may be 
     sold by a charitable remainder trust to be established by Mr. Cook.
 (4) Mr. Markey is an attorney and member of the law firm of Baker & Hostetler.
     Mr. Markey and Baker & Hostetler have in the past represented and 
     continue to represent Matrix in a variety of matters.  Of the shares
     of Common Stock proposed to be sold by Mr. Markey, up to 1,000 may be 
     donated by Mr. Markey to the Jewish Community Federation of Cleveland
     and sold in this offering.
 (5) Includes up to 1,200 shares of Common Stock which may be donated by 
     Mr. Miller to Grace Church of St. Louis and sold in this offering.


<PAGE>

                         PLAN OF DISTRIBUTION

          The Securities may be sold from time to time by the Selling
Shareholders, or by pledgees, donees, transferees or other successors
in interest. The Selling Shareholders have informed the Company that
they expect to engage Bear Stearns & Co. Inc. ("Bear Stearns") to act
on their behalf to sell the Securities. Such sales may be made on the
New York Stock Exchange, the Pacific Stock Exchange, on any other
exchange on which the Common Stock is traded (each, an "Exchange") or
in the over-the-counter market or otherwise, at prices and at terms
then prevailing or at prices related to the then current market price,
or in negotiated transactions. The Securities may be sold by one or
more of the following methods: (a) a block trade in which Bear Stearns
will attempt to sell the Securities as agent but may position and
resell a portion of the block as principal to facilitate the
transaction; (b) purchases by Bear Stearns as principal and resale by
such broker or dealer for its account pursuant to this Prospectus; (c)
an exchange distribution in accordance with the rules of the
applicable Exchange; and (d) ordinary brokerage transactions and
transactions in which Bear Stearns solicits purchasers. In effecting
sales, Bear Stearns may arrange for other brokers or dealers to
participate in the resales.

          In connection with distributions of the Securities or
otherwise, the Selling Shareholders may enter into hedging
transactions with Bear Stearns or other broker-dealers. In connection
with such transactions, broker-dealers may engage in short sales of
the Securities in the course of hedging the positions they assume with
Selling Shareholders. The Selling Shareholders may also sell
Securities short and redeliver the shares to close out such short
positions. The Selling Shareholders may also enter into option or
other transactions with broker-dealers which require the delivery to
such broker-dealer of the Securities offered hereby, which Securities
such broker-dealer may resell pursuant to this Prospectus. The Selling
Shareholders may also pledge the shares registered hereunder to Bear
Stearns or another broker or dealer and, upon a default, Bear Stearns
or such other broker or dealer may effect sales of the pledged
Securities pursuant to this Prospectus. In addition, any Securities
covered by this Prospectus which qualify for sale pursuant to Rule 144
may be sold under Rule 144 under the Securities Act rather than
pursuant to this Prospectus.

          Bear Stearns may receive compensation in the form of
customary brokerage commissions, discounts or concessions from Selling
Shareholders in amounts to be negotiated in connection with sales
pursuant hereto. Such brokers or dealers and any other participating
brokers or dealers may be deemed to be "underwriters" within the
meaning of the Securities Act, in connection with such sales and any
such commission, discount or concession may be deemed to be
underwriting discounts or commissions under the Securities Act.

          Certain costs, expenses and fees in connection with the
registration of the Securities, including certain costs of legal
counsel for the Selling Shareholders, will be borne by the Company.
Commissions, discounts and transfer taxes, if any, attributable to the
sales of the Securities will be borne by the Selling Shareholders, as
may a portion of the costs of legal counsel for the Selling
Shareholders. The Selling Shareholders have agreed to indemnify the
Company, all other prospective holders of the shares registered hereby
or any underwriter, as the case may be, and any of their respective
affiliates, directors, officers and controlling persons, against
certain liabilities in connection with the offering of the Securities
pursuant to this Prospectus, including liabilities arising under the
Securities Act. In addition,




<PAGE>


the Company has agreed to indemnify the Selling Shareholders, all
other prospective holders of the shares registered hereby or any
underwriter, as the case may be, and any of their respective
affiliates, directors, officers and controlling persons, against
certain liabilities in connection with the offering of the Securities
pursuant to this Prospectus, including liabilities arising under the
Securities Act.


                               EXPERTS

          The consolidated financial statements incorporated in this
Prospectus by reference to the Company's Annual Report on Form 10-K
for the fiscal year ended December 31, 1994, have been so incorporated
in reliance on the report of Price Waterhouse LLP, independent
accountants, given on the authority of said firm as experts in
accounting and auditing.


                      VALIDITY OF THE SECURITIES

          The validity of the Securities offered hereby was passed
upon for the Company by Cravath, Swaine & Moore, Worldwide Plaza, 825
Eighth Avenue, New York, New York, special counsel to the Company.



<PAGE>

           PART II. INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution.

         SEC registration fee.................................   $59,159
         Stock exchange listing fees .........................    33,200*
         Accounting fees......................................    10,000*
         Legal fees...........................................    45,000*
         Qualification under state securities laws............     5,000*
         Miscellaneous........................................     2,641*
                                                                $155,000*
                                                                =========

- ------------------
*  Estimated.


Item 15.  Indemnification of Directors and Officers.

          Section 145 of the Delaware General Corporation Law (the
"DGCL") provides that a corporation may indemnify directors and
officers as well as other employees and individuals against expenses
(including attorneys' fees), judgments, fines and amounts paid in
settlement in connection with specified actions, suits or proceedings,
whether civil, criminal, administrative or investigative (other than
an action by or in the right of the corporation, hereinafter a
"derivative action"), if they acted in good faith and in a manner they
reasonably believed to be in or not opposed to the best interests of
the corporation and, with respect to any criminal actions or
proceedings, had no reasonable cause to believe their conduct was
unlawful. A similar standard is applicable in the case of derivative
actions, except that indemnification only extends to expenses
(including attorneys' fees) actually and reasonably incurred in
connection with the defense or settlement of such action, and the DGCL
requires court approval before there can be any indemnification where
the person seeking indemnification has been found liable to the
corporation. The DGCL provides that it is not exclusive of other
indemnification that may be granted by a corporation's by-laws,
disinterested director vote, stockholder vote, agreement or otherwise.

          Under the terms of the Bylaws of the Company and subject to
the applicable provisions of the laws of the State of Delaware, the
Company has so indemnified each of its directors and officers, and any
employee of the Company who, at the Company's request, has served as a
director or officer of another corporation in which the Company owns
capital or of which it is a creditor, against expenses incurred or
paid in connection with any claim made against such director or
officer or any actual or threatened action, suit or proceeding in
which such director or officer may be involved by reason of being or
having been a director or officer of the Company, or of serving or
having served at the request of the Company as a director, officer,
employee or agent of another corporation, partnership, joint venture,
trust or other enterprise, or by reason of any action taken or not
taken by such director or officer in such capacity, and against the
amount or amounts paid by such director or officer in settlement of
any such claim, action, suit or proceeding or any judgment or order
entered therein.



<PAGE>


          Section 102(b)(7) of the DGCL permits a provision in the
certificate of incorporation of each corporation organized thereunder,
such as the Company, eliminating or limiting, with certain exceptions,
the personal liability of a director to the corporation or its
stockholders for monetary damages for breach of fiduciary duty as a
director. The Restated Certificate of Incorporation of the Company
eliminates the liability of directors of the Company to the extent
permitted by the DGCL.

          The Company has an insurance policy covering the liability
and expenses which might be incurred in connection with lawful
indemnification of directors and officers of the Company and its
majority owned subsidiaries for certain liabilities and expenses of
such directors and officers for acts in those capacities. Such
directors and officers are also insured against certain liabilities
and expenses incurred for acts in such capacities and for which they
are not entitled to indemnification by the Company.


Item 16.  Exhibits


     3.1    Restated Certificate of Incorporation of the Company,
            including the Certificate of Designations for the
            Convertible Preferred Stock (filed as Exhibit 4(a) to the
            Registration Statement on Form S-3 (No. 33-33682) filed on
            March 7, 1990 and incorporated herein by reference).*

     3.2    Bylaws of the Company, as amended through May 4, 1993
            (filed as Exhibit 3b to the Annual Report on Form 10-K for
            the fiscal year ended December 31, 1994 filed on March 29,
            1995 and incorporated herein by reference).*

     4.1    Registration Rights Agreement dated as of August 5, 1994
            among the Company and the Selling Shareholders.

     4.2    Rights Agreement, dated as of December 4, 1987 between the
            Company and Manufacturers Hanover Trust Company, as Rights
            Agent, as amended (filed as Exhibit 1 to the Registration
            Statement on Form 8-A dated December 10, 1987 and Exhibit
            1 to the Registration Statement on Form 8 dated July 27,
            1989, each of which are incorporated herein by
            reference).*

     5      Opinion of Cravath, Swaine & Moore, special counsel of the
            Company.

     23.1   Consent of Cravath, Swaine & Moore, special counsel of the
            Company (included in Exhibit 5).

     23.2   Consent of Price Waterhouse LLP.

     24     Powers of Attorney. 


- -----------------------
 * Incorporated by reference.


<PAGE>


Item 17.  Undertakings.

          A. Undertaking Pursuant to Rule 415.

          The Company hereby undertakes:

          (1) to file, during any period in which offers or sales are
     being made, a post- effective amendment to this Registration
     Statement:

               (i) to include any prospectus required by Section
          10(a)(3) of the Securities Act;

               (ii) to reflect in the prospectus any facts or events
          arising after the effective date of the Registration
          Statement (or the most recent post-effective amendment
          thereof) which, individually or in the aggregate, represent
          a fundamental change in the information set forth in the
          Registration Statement. Notwithstanding the foregoing, any
          increase or decrease in volume of securities offered (if the
          total dollar value of securities offered would not exceed
          that which was registered) and any deviation from the low or
          high end of the estimated maximum offering range may be
          reflected in the form of prospectus filed with the
          Commission pursuant to Rule 424(b) (ss. 230.424(b) of this
          chapter) if, in the aggregate, the changes in volume and
          price represent no more than a 20% change in the maximum
          aggregate offering price set forth in the "Calculation of
          Registration Fee" table in the effective registration
          statement;

               (iii) to include any material information with respect
          to the plan of distribution not previously disclosed in the
          Registration Statement or any material change to such
          information in the Registration Statement;

     provided, however, that paragraphs A(1)(i) and A(1)(ii) do not
     apply if the Registration Statement is on Form S-3 or Form S-8,
     and the information required to be included in a post-effective
     amendment by those paragraphs is contained in periodic reports
     filed by the Company pursuant to Section 13 or Section 15(d) of
     the Exchange Act that are incorporated by reference in the
     Registration Statement.

          (2) That, for the purpose of determining any liability under
     the Securities Act, each such post-effective amendment shall be
     deemed to be a new registration statement relating to the
     securities offered therein, and the offering of such securities
     at that time shall be deemed to be the initial bona fide offering
     thereof.

          (3) To remove from registration by means of a post-effective
     amendment any of the securities being registered which remain
     unsold at the termination of the offering.


<PAGE>

          B. Undertaking Regarding Filings Incorporating Subsequent
Exchange Act Documents by Reference.

          The Company hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Company's annual report pursuant to Section 13(a) or Section 15(d) of
the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to Section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement
shall be deemed to be a new Registration Statement relating to the
securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial bona fide offering
thereof.

          C. Undertaking in Respect of Indemnification.

          Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling
persons of the Company pursuant to the foregoing provisions, the
Company has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as
expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities
(other than the payment by the registrant of expenses incurred or paid
by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by
such director, officer or controlling person in connection with the
securities being registered, the Company will, unless in the opinion
of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in
the Securities Act and will be governed by the final adjudication of
such issue.




<PAGE>
                              SIGNATURES

          Pursuant to the requirements of the Securities Act of 1933,
the registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-3 and has
duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of New York,
State of New York, on the 17th day of July, 1995.


                              BRISTOL-MYERS SQUIBB COMPANY,

                             by
                                 /s/  Charles A. Heimbold, Jr.
                                 -----------------------------
                                 Name:  Charles A. Heimbold, Jr.
                                 Title: President, Chief Executive
                                        Officer, Chairman of the
                                        Board and Director


          Pursuant to the requirements of the Securities Act of 1933,
this registration statement (on Form S-3) has been signed by the
following persons in the capacities and on the date indicated:


Signature                          Title                         Date
- ---------                          -----                         ----

                                   President, Chief Executive    07/17/95
                                   Officer, Chairman of the
                                   and Director (principal
/s/  Charles A. Heimbold, Jr.      executive officer)
- ----------------------------
Charles A. Heimbold, Jr.


                                   Corporate Staff Senior Vice   07/17/95
                                   President and Chief Financial                
                                   Officer (principal finanical
/s/  Michael F. Mee                officer)
- -------------------                
Michael F. Mee


                                   Corporate Staff Vice          07/17/95
                                   President and Controller
                                   (principal accounting
/s/  Frederick S. Schiff           officer)
- ------------------------
Frederick S. Schiff

<PAGE>


Signature                          Title                         Date
- ---------                          -----                         ----

                                  Director                       07/17/95
/s/  Robert E. Allen
- --------------------
Robert E. Allen


                                  Executive Vice                 07/17/95
                                  President and
                                  Director
/s/  Michael E. Autera
- ----------------------
Michael E. Autera




                                  Director                       07/17/95
/s/  Ellen V. Futter
- --------------------
Ellen V. Futter



                                  Director                       07/17/95
/s/  Louis V. Gerstner, Jr.
- ---------------------------
Louis V. Gerstner, Jr.




                                  Director                       07/17/95
/s/  John D. Macomber
- ---------------------
John D. Macomber



                                  Director                       07/17/95
/s/ James D. Robinson III
- ---------------------------
James D. Robinson III




                                  Director                       07/17/95
/s/  Andrew C. Sigler
- ---------------------
Andrew C. Sigler

<PAGE>

Signature                          Title                         Date
- ---------                          -----                         ----


                                  Director                       07/17/95
/s/  Louis W. Sullivan, M.D.
- ----------------------------
Louis W. Sullivan, M.D.



                                  Director                       07/17/95
/s/  Kenneth E. Weg
- -------------------
Kenneth E. Weg


<PAGE>



                            EXHIBIT INDEX


                                                                 Sequentially
Exhibit No.         Description                                 Numbered Page
- -----------         -----------                                 -------------
 
   3.1              Restated Certificate of Incorporation             *
                    of the Company, including the Certificate
                    of Designations for the Convertible
                    Preferred Stock (filed as Exhibit 4(a) 
                    to the Registration Statement on 
                    Form S-3 (No. 33-33682) filed on 
                    March 7, 1990 and incorporated herein
                    by reference).

   3.2              Bylaws of the Company, as amended                 *
                    through May 4, 1993 (filed as
                    Exhibit 3b to the Annual Report on
                    Form 10-K for the fiscal year ended
                    December 31, 1994 filed on March
                    29, 1995 and incorporated herein by
                    reference).

   4.1              Registration Rights Agreement dated
                    as of August 5, 1994 among the
                    Company and the Selling
                    Shareholders.

   4.2              Rights Agreement, dated as of                     *
                    December 4, 1987 between the
                    Company and Manufacturers Hanover
                    Trust Company, as Rights Agent, as
                    amended (filed as Exhibit 1 to the
                    Registration Statement on Form 8-A
                    dated December 10, 1987 and Exhibit
                    1 to the Registration Statement on
                    Form 8 dated July 27, 1989, each of
                    which are incorporated herein by
                    reference).

   5                Opinion of Cravath, Swaine & Moore,
                    special counsel of the Company.

   23.1             Consent of Cravath, Swaine & Moore,
                    special counsel of the Company
                    (included in Exhibit 5).

   23.2             Consent of Price Waterhouse LLP.

   24               Powers of Attorney.


- ----------------------
* Incorporated by reference.

                                                           EXHIBIT 4.1


                                                        EXECUTION COPY







                                   REGISTRATION RIGHTS AGREEMENT dated
                              as of August 5, 1994, among
                              BRISTOL-MYERS SQUIBB COMPANY, a Delaware
                              corporation ("BMS"), and the individuals
                              and entities named in Schedule I hereto
                              (herein referred to collectively as the
                              "Shareholders" and individually as a
                              "Shareholder").

          This Agreement is made pursuant to Section 5.09 of the
Agreement and Plan of Merger dated as of June 14, 1994 (the "Merger
Agreement"), among BMS, BMS Acquisition Sub Corp. I, BMS Acquisition
Sub Corp. II, Matrix Essentials, Inc., Lauren Stacy Marketing, Inc.,
the Trust Shareholders named therein, the Lauren Stacy Shareholders
named therein, the Limited Partners named therein, Sydell L. Miller,
the Estate of Arnold M. Miller, Stacie Miller Halpern and Lauren
Miller Spilman. In order to induce the Shareholders to consummate the
transactions contemplated by the Merger Agreement, and in further
consideration therefor, BMS has agreed to execute and deliver this
Agreement and provide the registration rights set forth in this
Agreement.

          Accordingly, it is hereby agreed as follows:

          1. Securities Subject to this Agreement. (a) Definitions.
Capitalized terms used but not otherwise defined herein shall have the
meanings assigned to such terms in the Merger Agreement. For purposes
of this Agreement the following terms shall have the following
meanings:

          "Effective Period" shall mean a period commencing on the
date of this Agreement and ending on the earlier of (i) the first date
as of which all Registrable Securities cease to be Registrable
Securities and (ii) the date two years following the Closing Date.

          "Holder" shall mean a holder of Registrable Securities.

          "Registrable Securities" means, collectively, (i) the shares
of common stock, par value $.10 per share, of BMS ("Common Stock")
issued in connection with the Mergers and the Acquisitions (the
"Shares") and (ii) any securities issued or distributed in respect of
any Shares by way of stock dividend or stock split or in connection
with a combination of shares, recapitalization, reorganization,
merger, consolidation or otherwise.


<PAGE>

          "Registration Expenses" shall mean any and all expenses
incident to performance of or compliance with this Agreement,
including, without limitation, (i) all SEC and securities exchange
registration and filing fees, (ii) all fees and expenses of complying
with securities or blue sky laws (including fees and disbursements of
counsel for any underwriters in connection with blue sky
qualifications of the Registrable Securities), (iii) all printing,
messenger and delivery expenses, (iv) all fees and expenses incurred
in connection with the listing of the Registrable Securities on any
securities exchange pursuant to Section 5(h), (v) the fees and
disbursements of counsel for BMS and of its independent public
accountants, including the expenses of any incident to such
performance and compliance, (vi) the reasonable fees and disbursements
of one counsel, other than BMS's counsel, selected by the Holders of a
majority of the Registrable Securities being registered to represent
all Holders of the Registrable Securities being registered in
connection with each such registration (it being understood that any
Holder may, at its own expense, retain separate counsel to represent
it in connection with such registration), and (vii) any fees and
disbursements of underwriters customarily paid by the issuers or
sellers of securities, and the reasonable fees and expenses of any
special experts retained in connection with the requested
registration, but excluding underwriting discounts and commissions and
transfer taxes, if any.

          "Related Securities" means any securities of BMS similar or
identical to any of the Registrable Securities, including, without
limitation, Common Stock and all options, warrants and other
securities convertible into, or exchangeable or exercisable for,
Common Stock.

          (b) Registrable Securities. For the purposes of this
Agreement, Registrable Securities will cease to be Registrable
Securities when (i) a registration statement covering such Registrable
Securities has been declared effective under the Securities Act (as
defined below) and they have been disposed of pursuant to such
effective registration statement, (ii) they are distributed to the
public pursuant to Rule 144 (or any similar provision then in force)
under the Securities Act of 1933 (the "Securities Act"), (iii) they
shall have been otherwise transferred, new certificates for them not
bearing a legend restricting further transfer shall have been
delivered by BMS and subsequent disposition of them shall not require
registration or qualification of them under the Securities


<PAGE>


Act or any state securities or blue sky law then in force, (iv) two
years following the date of this Agreement have elapsed or (v) they
shall have ceased to be outstanding.

          2. Demand Registration Rights. (a) Right to Demand. Any
Holder or Holders of a number of Registrable Securities equal to at
least 10% of the Registrable Securities issued in connection with the
Mergers and the Acquisitions (with a proportional adjustment for any
stock split or stock dividend or other issuance of securities with
respect to such Registrable Securities) may make a written request to
BMS for registration with the SEC under and in accordance with the
provisions of the Securities Act of all or part of their Registrable
Securities and BMS shall use its best efforts to effect such
registration (a "Demand Registration"); provided, however, that (i)
the aggregate number of Registrable Securities requested to be so
registered shall have a market value (calculated using the market
price of such Registrable Securities on the date of receipt by BMS of
such written request) of at least $40,000,000 and (ii) no Demand
Registration may be requested after the end of the Effective Period
and provided, further, that BMS shall not be obligated to file a
registration statement relating to any registration request under this
Section 2, (x) within a period of six months after the effective date
of any other registration statement relating to (A) any registration
request under this Section 2 or (B) any registration of the type
described under Section 3 pursuant to which any Holder disposed of
Registrable Securities, or (y) if with respect thereto, the managing
underwriter, the SEC, the Securities Act or the form on which the
registration statement is to be filed, would require the conduct of an
audit other than the regular audit conducted by BMS at the end of its
fiscal year, in which case the filing may be delayed until the
completion of such regular audit (unless the Holders of the
Registrable Securities to be registered agree to pay the expenses of
BMS in connection with such an audit other than the regular audit).
Within 10 days after receipt of such request, BMS will serve written
notice (the "Notice") of such registration request to all Holders of
Registrable Securities and BMS will include in such registration all
Registrable Securities of such Holders with respect to which BMS has
received written requests for inclusion therein within 15 days after
the receipt by the applicable Holder of the Notice. Any request for
registration made by a Holder pursuant to this paragraph 2(a) will
specify the aggregate


<PAGE>


number of Registrable Securities to be registered and will also
specify the intended methods of disposition thereof.

          (b)  Blackout Period. BMS shall be entitled to postpone the
filing of any registration statement otherwise required to be prepared
and filed by BMS pursuant to this Section 2, for a reasonable period
of time, but not in excess of 90 days (a "Blackout Period"), if any
executive officer of BMS determines that in such executive officer's
reasonable judgment and good faith that the registration and
distribution of the Registrable Securities would materially interfere
with any pending financing, acquisition or corporate reorganization or
other corporate development involving BMS or any of its Subsidiaries
or would require premature disclosure thereof and promptly gives the
Holders of Registrable Securities to be registered written notice of
such determination, containing a general statement of the reasons for
such postponement and an approximation of the anticipated delay;
provided, however, that the aggregate number of days included in all
Blackout Periods during any consecutive 12 months during the Effective
Period shall not exceed 180 days and provided, further, however, that
a period of at least 30 days shall elapse between the termination of
any Blackout Period and the commencement of the immediately succeeding
Blackout Period. If BMS shall so postpone the filing of a registration
statement, the Holders of Registrable Securities to be registered
shall have the right to withdraw the request for registration by
giving written notice from the Holders of a majority of the
Registrable Securities that were to be registered to BMS within 20
days after receipt of the notice of postponement (and, in the event of
such withdrawal, such request shall not be counted for purposes of
determining the number of requests for registration to which the
Holders of Registrable Securities are entitled pursuant to paragraph
(c) of this Section 2).

          (c) Number of Demand Registrations. The Holders of
Registrable Securities shall be entitled to a maximum of three Demand
Registrations during the Effective Period. BMS shall not be deemed to
have effected a Demand Registration unless and until such Demand
Registration is declared effective under the Securities Act; provided,
however, that if after any Demand Registration has been declared
effective, the offering of any Registrable Securities pursuant to such
Demand Registration is interfered with by any stop order, injunction
or other order or requirement of the SEC or its staff or any other
governmental agency or

<PAGE>

court, such Demand Registration will be deemed not to have been
effected for the purposes of this Agreement unless (i) such stop
order, injunction or other order or requirement relates to the actions
or omissions of, information included in the prospectus related to, or
is otherwise attributable to the Holders or the Registrable Securities
or (ii) if such stop order, injunction or other or requirement is
lifted or otherwise ceases to be applicable to such Demand
Registration.

          (d) Priority on Demand Registrations. If the managing
underwriter or underwriters of a Demand Registration advise BMS in
writing that in its or their opinion the number of securities proposed
to be sold in such Demand Registration exceeds the number which can be
sold in such offering, BMS will include in such registration only the
number of securities that, in the opinion of such underwriter or
underwriters can be sold, selected pro rata among the Holders that
have requested to be included in such Demand Registration.

          (e) Selection of Underwriters. If any offering pursuant to a
Demand Registration is an underwritten offering, BMS will select a
managing underwriter or underwriters to administer the offering, which
managing underwriter or underwriters shall be reasonably satisfactory
to the Holders of a majority in number of the Registrable Securities
to be included in such Demand Registration; provided, however, that
the Holders of a majority in number of the Registrable Securities to
be included in such Demand Registration shall be entitled to select
one co-managing underwriter, which co-managing underwriter shall be
reasonably satisfactory to BMS. The managing underwriter or
underwriters selected by BMS shall be deemed to be reasonably
satisfactory to the Holders of a majority in number of the Registrable
Securities to be registered unless the Holders of a majority in number
of such Registrable Securities send a written notice of objection to
BMS within 10 days of receipt of notice from BMS of the appointment of
a managing underwriter or underwriters.

          3. Piggy-Back Registration. If at any time after the date of
issuance of any Registrable Securities and prior to the end of the
Effective Period, BMS proposes to file a registration statement under
the Securities Act with respect to an offering by BMS for its own
account or for the account of others of any class of equity security
(or any options, warrants or other securities convertible into, or

<PAGE>

exchangeable or exercisable for, equity securities) to be offered for
cash (other than in connection with the registration of securities
issuable pursuant to an employee stock option, stock purchase or
similar plan or pursuant to a merger, exchange offer or a transaction
of the type specified in Rule 145(a) under the Securities Act), then
BMS shall in each case give written notice of such proposed filing to
the Holders at least 20 days before the filing date, and such notice
shall offer such Holders the opportunity to register such number of
Registrable Securities as each such Holder may request (a "Piggy-Back
Registration"). If such offer is accepted by written notice to BMS
from the Holders of at least 10% of the Registrable Securities issued
in connection with the Mergers and the Acquisitions (with a
proportional adjustment for any stock split or stock dividend or other
issuance of securities with respect to such Registrable Securities)
within 15 days of the giving of the written notice provided for in the
preceding sentence, BMS shall use its best efforts to permit, or (in
the case of a proposed underwritten offering) to cause the managing
underwriter or underwriters thereof to permit, the Holders of
Registrable Securities requested to be included, in the registration
for such offering to include such Registrable Securities in such
offering on the same terms and conditions as the corresponding
securities of BMS included therein, provided that (i) if, at any time
after giving written notice of its intention to register any
securities and prior to the effective date of the registration
statement filed in connection with such registration, BMS shall
determine for any reason not to proceed with the proposed
registration, BMS may, at its election, give written notice of such
determination to each Holder of Registrable Securities requested to be
included in such registration and thereupon shall be relieved of its
obligation to register any Registrable Securities in connection with
such registration (but not from its obligation to pay the Registration
Expenses in connection therewith), and (ii) if such registration
involves an underwritten offering by BMS (underwritten, at least in
part, by Persons who are not Affiliates or Associates of BMS or any
Holder), all Holders requesting to have Registrable Securities
included in BMS's registration must sell their Registrable Securities
to such underwriters who shall have been selected by BMS on the same
terms and conditions as apply to BMS, with such differences, including
any with respect to indemnification and contribution, as may be
customary or appropriate in combined primary and secondary offerings.
If a proposed registration pursuant to this


<PAGE>


Section 3 involves such an underwritten public offering, any Holder
making a request under this Section 3 in connection with such
registration may elect in writing, prior to the effective date of the
registration statement filed in connection with such registration, to
withdraw such request and not to have such securities registered in
connection with such registration. Notwithstanding the foregoing, if
the managing underwriter or underwriters of a proposed underwritten
offering advise BMS in writing that in their opinion the total amount
or kind of securities that the Holders have requested to be included
in such offering would adversely affect the success of such offering,
then the amount of securities to be offered for the accounts of
Holders of Registrable Securities shall be reduced pro rata to the
extent necessary to reduce the total amount of securities to be
included in such offering to the amount recommended by such managing
underwriter or underwriters.

          4. Holdback Agreement. If (i) during the Effective Period
BMS shall file a registration statement (other than in connection with
the registration of securities issuable pursuant to an employee stock
option, stock purchase or similar plan or pursuant to a merger,
exchange offer or a transaction of the type specified in Rule 145(a)
under the Securities Act) with respect to its Common Stock or similar
securities or securities convertible into, or exchangeable or
exercisable for, such securities and (ii) with reasonable prior
notice, BMS (in the case of a non-underwritten public offering by BMS
pursuant to such registration statement) advises the Shareholders in
writing that a public sale or distribution of such Registration
Securities would materially adversely affect such offering or the
managing underwriter or underwriters (in the case of an underwritten
public offering by BMS pursuant to such registration statement)
advises BMS in writing (in which case BMS shall notify the
Shareholders) that a public sale or distribution of such Registrable
Securities would materially adversely impact such offering, then each
Shareholder that is then a Holder of Registrable Securities shall, to
the extent not inconsistent with Applicable Law, refrain from
effecting any public sale or distribution of Registrable Securities
(except in accordance with Section 2 hereof) during the seven days
prior to, and during the 60-day period beginning on, the effective
date of such registration statement. In the event that the Holders are
required so to refrain from effecting any public sale or distribution
during any period during which a registration statement relating to a
Demand Registration is required to


<PAGE>

be kept effective pursuant to Section 5(b) hereof, the period
mentioned in Section 5(b) shall be extended by the number of days that
the Holders are so required to refrain from public sale or
distribution.

          5. Registration Procedures. If and whenever BMS is required
to use its best efforts to effect or cause the registration of any
Registrable Securities under the Securities Act as provided in this
Agreement, BMS will, as expeditiously as possible:

          (a) prepare and file with the SEC a registration statement
     with respect to such Registrable Securities on any form for which
     BMS then qualifies or which counsel for BMS shall deem
     appropriate, and which form shall be available for the sale of
     the Registrable Securities in accordance with the intended
     methods of distribution thereof, and use its best efforts to
     cause such registration statement to become and remain effective;
     provided, however, that BMS may discontinue any registration of
     its securities which is being effected pursuant to Section 3 at
     any time prior to the effective date of the registration
     statement relating thereto;

          (b) prepare and file with the SEC amendments and supplements
     to such registration statement and the prospectus used in
     connection therewith as may be necessary to maintain the
     effectiveness of such registration and to comply with the
     provisions of the Securities Act with respect to the disposition
     of all securities covered by such registration statement until
     the earlier of such time as all of such securities have been
     disposed of in accordance with the intended methods of
     disposition by the Holder or Holders thereof set forth in such
     registration statement or the expiration of 90 days after such
     registration statement becomes effective; provided, that before
     filing a registration statement or prospectus, or any amendments
     or supplements thereto, BMS will furnish to the Holders and their
     counsel, copies of all documents proposed to be filed;

          (c) furnish to each Holder of such Registrable Securities
     such number of copies of such registration statement and of each
     amendment and supplement thereto (in each case including all
     exhibits), such number of copies of the prospectus and prospectus
     supplement, as


<PAGE>


     applicable), in conformity with the requirements of the
     Securities Act, and such other documents as such Holder may
     reasonably request in order to facilitate the disposition of the
     Registrable Securities by such Holder;

          (d) use its best efforts to register or qualify such
     Registrable Securities covered by such registration statement
     under such other securities or blue sky laws of such
     jurisdictions as each Holder shall reasonably request, and do any
     and all other acts and things which may be reasonably necessary
     or advisable to enable such Holder to consummate the disposition
     in such jurisdictions of the Registrable Securities owned by such
     Holder, except that BMS shall not for any such purpose be
     required to qualify generally to do business as a foreign
     corporation in any jurisdiction where, but for the requirements
     of this Section 5(d), it would not be obligated to be so
     qualified, to subject itself to taxation in any such
     jurisdiction, or to consent to general service of process in any
     such jurisdiction;

          (e) use its best efforts to cause such Registrable
     Securities covered by such registration statement to be
     registered with or approved by such other governmental agencies
     or authorities as may be necessary to enable the Holder or
     Holders thereof to consummate the disposition of such Registrable
     Securities;

          (f) notify each Holder of any such Registrable Securities
     covered by such registration statement, at any time when a
     prospectus relating thereto is required to be delivered under the
     Securities Act within the appropriate period mentioned in Section
     5(b), of BMS's becoming aware that the prospectus included in
     such registration statement, as then in effect, includes an
     untrue statement of a material fact or omits to state a material
     fact required to be stated therein or necessary to make the
     statements therein not misleading in light of the circumstances
     then existing, and at the request of any such Holder, prepare and
     furnish to such Holder a reasonable number of copies of an
     amended or supplemental prospectus as may be necessary so that,
     as thereafter delivered to the purchasers of such Registrable
     Securities, such prospectus shall not include an untrue statement
     of a material fact or omit

<PAGE>

     to state a material fact required to be stated therein or
     necessary to make the statements therein not misleading in light
     of the circumstances then existing;

          (g) otherwise use its best efforts to comply with all
     applicable rules and regulations of the SEC, and make available
     to its security holders, as soon as reasonably practicable (but
     not more than eighteen months) after the effective date of the
     registration statement, an earnings statement which shall satisfy
     the provisions of Section 11(a) of the Securities Act and the
     rules and regulations promulgated thereunder;

          (h) use its best efforts to cause all such Registrable
     Securities to be listed on any securities exchange on which the
     Common Stock is then listed, if such Registrable Securities are
     not already so listed and if such listing is then permitted under
     the rules of such exchange, and to provide a transfer agent and
     registrar for such Registrable Securities covered by such
     registration statement no later than the effective date of such
     registration statement;

          (i) comply with the requirements of Section 153 of the
     Securities Act regarding delivery of prospectuses;

          (j) use its best efforts to obtain a "cold comfort" letter
     or letters from BMS's independent public accountants in customary
     form;

          (k) cooperate with the Holders of Registrable Securities
     covered by such registration statement and the managing
     underwriter or underwriters, if any, to facilitate the timely
     preparation and delivery of certificates (not bearing any
     restrictive legends) representing the securities to be sold under
     such registration statement, and enable such securities to be in
     such denominations and registered in such names as the managing
     underwriter or underwriters, if any, or such Holders may request;
     and

          (l) make available for inspection by any Holder of
     Registrable Securities included in such registration statement,
     any underwriter participating in any disposition pursuant to such
     registration statement, and any attorney, accountant or other
     agent retained by any such Holder or underwriter (collectively,
     the


<PAGE>


     "Inspectors"), all financial and other records and other
     information, pertinent corporate documents and properties of any
     of BMS and its subsidiaries and affiliates (collectively, the
     "Records"), as shall be reasonably necessary to enable them to
     exercise their due diligence responsibility; provided, however,
     that the Records that BMS determines, in good faith, to be
     confidential and which it notifies the Inspectors in writing are
     confidential shall not be disclosed to any Inspector unless such
     Inspector signs a confidentiality agreement reasonably
     satisfactory to BMS or either (i) the disclosure of such Records
     is necessary to avoid or correct a misstatement or omission in
     such registration statement or (ii) the release of such Records
     is ordered pursuant to a subpoena or other order from a court of
     competent jurisdiction; provided further, however, that any
     decision regarding the disclosure of information pursuant to
     subclause (i) shall be made only after consultation with counsel
     for the applicable Inspectors. Each Holder of Registrable
     Securities agrees that it will, promptly after learning that
     disclosure of such Records is sought in a court having
     jurisdiction, give notice to BMS and allow BMS, at BMS's expense,
     to undertake appropriate action to prevent disclosure of such
     Records.

          BMS may require each Holder of Registrable Securities as to
which any registration is being effected to furnish BMS with such
information regarding such Holder and pertinent to the disclosure
requirements relating to the registration and the distribution of such
securities as BMS may from time to time reasonably request in writing.

          Each Holder of Registrable Securities agrees that, upon
receipt of any notice from BMS of the happening of any event of the
kind described in Section 5(f), such Holder will forthwith discontinue
disposition of Registrable Securities pursuant to the registration
statement covering such Registrable Securities until such Holder's
receipt of the copies of the supplemented or amended prospectus
contemplated by Section 5(f), and, if so directed by BMS, such Holder
will deliver to BMS (at BMS's expense) all copies, other than
permanent file copies then in such Holder's possession, of the
prospectus covering such Registrable Securities current at the time of
receipt of such notice. In the event BMS shall give any such notice,
the period mentioned in Section 5(b) shall be extended by

<PAGE>


the number of days during the period from the date of the giving of
such notice pursuant to Section 5(f) and through the date when each
seller of Registrable Securities covered by such registration
statement shall have received the copies of the supplemented or
amended prospectus contemplated by Section 5(f).

          6. Registration Expenses. BMS will pay all Registration
Expenses in connection with the first three registrations of
Registrable Securities pursuant to Section 2 or 3 upon the written
request of any of the Holders, and each Holder shall pay all
underwriting discounts and commissions and transfer taxes, if any,
relating to the sale or disposition of such Holder's Registrable
Securities pursuant to a registration statement effected pursuant to
such Sections. The fees and expenses of counsel to the Holders that
are paid by BMS pursuant to this Agreement shall not exceed $50,000
per registration. All expenses for any subsequent registrations of
Registrable Securities pursuant to either Section 2 or 3 shall be paid
pro rata by all Persons (including the Holders and BMS) participating
in such registration on the basis of the relative number of shares of
Common Stock of each such Person included in such registration.

          7. Indemnification; Contribution. (a) Indemnification by
BMS. BMS agrees to indemnify each Holder of Registrable Securities,
its officers and directors and each Person who controls such Holder
(within the meaning of the Securities Act), and any agent or
investment adviser thereof against all losses, claims, damages,
liabilities and expenses (including reasonable attorneys' fees and
expenses of investigation) incurred by such party pursuant to any
actual or threatened action, suit, proceeding or investigation arising
out of or based upon (i) any untrue or alleged untrue statement of
material fact contained in any registration statement, any prospectus
or preliminary prospectus, or any amendment or supplement to any of
the foregoing or (ii) any omission or alleged omission to state
therein a material fact required to be stated therein or necessary to
make the statements therein (in the case of a prospectus or a
preliminary prospectus, in light of the circumstances then existing)
not misleading, except in each case insofar as the same arise out of
or are based upon, any such untrue statement or omission made in
reliance on and in conformity with information with respect to such
indemnified party furnished in writing to BMS by such indemnified
party or its counsel expressly for use therein. In connection

<PAGE>


with an underwritten offering, BMS will indemnify the underwriters
thereof, their officers and directors and each Person who controls
such underwriters (within the meaning of the Securities Act) to the
same extent as provided above with respect to the indemnification of
the Holders of Registrable Securities. Notwithstanding the foregoing
provisions of this paragraph 7(a), BMS will not be liable to any
Holder of Registrable Securities, any Person who participates as an
underwriter in the offering or sale of Registrable Securities or any
other Person, if any, who controls such Holder or underwriter (within
the meaning of the Securities Act), under the indemnity agreement in
this paragraph 7(a) for any such loss, claim, damage, liability (or
action or proceeding in respect thereof) or expense that arises out of
such Holder's or other Person's failure to send or give a copy of the
final prospectus to the Person asserting an untrue statement or
alleged untrue statement or omission or alleged omission at or prior
to the written confirmation of the sale of the Registrable Securities
to such Person if such statement or omission was corrected in such
final prospectus and BMS has previously furnished copies thereof in
accordance with this Agreement.

          (b) Indemnification by Holders of Registrable Securities. In
connection with any registration statement in which a Holder of
Registrable Securities is participating, each such Holder will furnish
to BMS in writing such information, including with respect to the
name, address and the amount of Registrable Securities held by such
Holder, as BMS reasonably requests for use in such registration
statement or the related prospectus and agrees to indemnify and hold
harmless (in the same manner and to the same extent as set forth in
Section 7(a)) BMS, all other prospective Holders or any underwriter,
as the case may be, and any of their respective affiliates, directors,
officers and controlling Persons, (within the meaning of the
Securities Act) against any losses, claims, damages, liabilities and
expenses resulting from any untrue or alleged untrue statement of a
material fact or any omission or alleged omission of a material fact
required to be stated in such registration statement or prospectus or
any amendment or supplement to either of them or necessary to make the
statements therein (in the case of a prospectus, in the light of the
circumstances then existing) not misleading, but only to the extent
that any such untrue statement or omission is made in reliance on and
in conformity with information with respect to such Holder


<PAGE>


furnished in writing to BMS by such Holder or its counsel specifically
for inclusion therein.

          (c) Conduct of Indemnification Proceedings. Any Person
entitled to indemnification hereunder agrees to give prompt written
notice to the indemnifying party after the receipt by such indemnified
party of any written notice of the commencement of any action, suit,
proceeding or investigation or threat thereof made in writing for
which such indemnified party may claim indemnification or contribution
pursuant to this Agreement. In case any such action shall be brought
against any indemnified party and it shall notify the indemnifying
party of the commencement thereof, the indemnifying party shall be
entitled to participate therein and, to the extent that it shall wish,
jointly with any other indemnifying party similarly notified, to
assume the defense thereof, with counsel satisfactory to such
indemnified party (who shall not, except with the consent of the
indemnified party, be counsel to the indemnifying party), and after
notice from the indemnifying party to such indemnified party of its
election so to assume the defense thereof, the indemnifying party
shall not be liable to such indemnified party under these
indemnification provisions for any legal expenses of other counsel or
any other expenses, in each case subsequently incurred by such
indemnified party, in connection with the defense thereof other than
reasonable costs of investigation, unless in the reasonable judgment
of any indemnified party a conflict of interest is likely to exist
between such indemnified party and any other of such indemnified
parties with respect to such claim, in which event the indemnifying
party shall be obligated to pay the reasonable fees and expenses of
such additional counsel or counsels. The indemnifying party will not
be subject to any liability for any settlement made without its
consent (which will not be unreasonably withheld).

          (d) Contribution. If the indemnification from the
indemnifying party provided for in this paragraph 7 is unavailable to
an indemnified party hereunder in respect of any losses, claims,
damages, liabilities or expenses referred to therein, then the
indemnifying party, in lieu of indemnifying such indemnified party,
shall contribute to the amount paid or payable by such indemnified
party as a result of such losses, claims, damages, liabilities and
expenses in such proportion as is appropriate to reflect the relative
fault of the indemnifying party and indemnified party in connection
with the actions which resulted in such losses,


<PAGE>

claims, damages, liabilities and expenses, as well as any other
relevant equitable considerations. The relative fault of such
indemnifying party and indemnified party shall be determined by
reference to, among other things, whether any action in question,
including any untrue or alleged untrue statement of a material fact or
omission or alleged omission to state a material fact, has been made
by, or relates to information supplied by, such indemnifying party or
indemnified party, and the parties' relative intent, knowledge, access
to information and opportunity to correct or prevent such action. The
amount paid or payable by a party as a result of the losses, claims,
damages, liabilities and expenses referred to above shall be deemed to
include, subject to the limitations set forth in paragraph 7(c), any
legal and other fees and expenses reasonably incurred by such
indemnified party in connection with any investigation or proceeding.

          The parties hereto agree that it would not be just and
equitable if contribution pursuant to this paragraph 7(d) were
determined by pro rata allocation or by any other method of allocation
which does not take account of the equitable considerations referred
to in the immediately preceding paragraph. Notwithstanding the
provisions of this paragraph 7(d), no underwriter shall be required to
contribute any amount in excess of the amount by which the total price
at which the Registrable Securities underwritten by it and distributed
to the public were offered to the public exceeds the amount of any
damages which such underwriter has otherwise been required to pay by
reason of such untrue or alleged untrue statement or omission or
alleged omission, and no Holder of Registrable Securities shall be
required to contribute any amount in excess of the amount by which the
total price at which the Registrable Securities of such Holder were
offered to the public (net of all underwriting discounts and
commissions) exceeds the amount of any damages which such Holder has
otherwise been required to pay by reason of such untrue statement or
omission. No Person guilty of fraudulent misrepresentation (within the
meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution from any Person who was not guilty of such fraudulent
misrepresentation.

          If indemnification is available under this paragraph 7, the
indemnifying parties shall indemnify each indemnified party to the
full extent provided in paragraph 7(a) or (b), as the case may be,
without regard to


<PAGE>


the relative fault of said indemnifying parties or indemnified party
or any other equitable consideration provided for in this paragraph
7(d).

          (e) The provisions of this paragraph 7 shall be applicable
in respect of each registration pursuant to this Agreement, shall be
in addition to any liability which any party may have to any other
party and shall survive any termination of this Agreement.

          8. Participation in Underwritten Registrations. No Holder of
Registrable Securities may participate in any underwritten
registration hereunder unless such Holder (a) agrees to sell such
Holder's securities on the basis provided in any underwriting
arrangements approved by BMS in its reasonable discretion and (b)
completes and executes all questionnaires, powers of attorney,
indemnities, underwriting agreements and other documents reasonably
required under the terms of such underwriting arrangements.

          9. Rule 144. For a period of three years following the
Closing Date, BMS covenants that it will file the reports required to
be filed by it under the Securities Act and the Securities Exchange
Act of 1934, as amended, and the rules and regulations adopted by the
Commission thereunder (or, if BMS is not required to file such
reports, it will, upon the request of any Holder of Registrable
Securities, make publicly available other information so long as
necessary to permit sales under Rule 144 under the Securities Act),
and it will take such further action as any Holder of Registrable
Securities may reasonably request, all to the extent required from
time to time to enable such Holder to sell Registrable Securities
without registration under the Securities Act within the limitation of
the exemptions provided by (a) Rule 144 under the Securities Act, as
such Rule may be amended from time to time, or (b) any similar rule or
regulation hereafter adopted by the Commission. Upon the request of
any Holder of Registrable Securities, BMS will deliver to such Holder
a written statement as to whether it has complied with such
requirements.

          10. Miscellaneous. (a) Remedies. Each Holder of Registrable
Securities in addition to being entitled to exercise all rights
granted by law, including recovery of damages, will be entitled to
specific performance of its rights under this Agreement.


<PAGE>

          (b) Amendments and Waivers. Except as otherwise provided
herein, the provisions of this Agreement may not be amended, modified
or supplemented, and waivers or consents to departures from the
provisions hereof may not be given, unless BMS has obtained the
written consent of Holders of at least a majority in number of the
Registrable Securities then outstanding.

          (c) Notices. All Notices and other communications provided
for or permitted hereunder shall be in writing and shall be deemed to
have been duly given if delivered personally or sent by telex or
telecopier, registered or certified mail (return receipt requested),
postage prepaid, or courier guaranteeing next day delivery to the
parties at the following addresses (or at such other address for any
party as shall be specified by like notice, provided that notices of a
change of address shall be effective only upon receipt thereof).
Notices delivered personally shall be effective upon receipt, notices
sent by mail shall be effective three days after mailing, notices sent
by telex shall be effective when answered back, notices sent by
telecopier shall be effective when receipt is acknowledged, and
notices sent by courier guaranteeing next day delivery shall be
effective on the next business day after timely delivery to the
courier:

          (i) if to a Holder of Registrable Securities at the address
     of such Holder provided in Schedule I hereto or at such other
     address as the applicable Holder may designate to BMS in writing;
     and

         (ii) if to BMS at:

                        Bristol-Myers Squibb Company
                        345 Park Avenue
                        New York, New York 10154

                        Attention:  George P. Kooluris
                        Senior Vice-President, Corporate
                        Development

<PAGE>

              with a copy to:

                        Bristol-Myers Squibb Company
                        345 Park Avenue
                        New York, New York 10154

                       Attention:  General Counsel

          (d) Successors and Assigns. This Agreement shall inure to
the benefit of and be binding upon the successors and permitted
assigns of each of the parties; provided, however that this Agreement
and the provisions of this Agreement that are for the benefit of the
Shareholders or any Holder shall not be assignable by any Shareholder
to any Person other than another Shareholder.

          (e) Counterparts. This Agreement may be executed in any
number of counterparts and by the parties hereto in separate
counterparts, each of which when so executed shall be deemed to be an
original and all of which taken together shall constitute one and the
same agreement.

          (f) Headings. The headings in this Agreement are for
convenience of reference only and shall not limit or otherwise affect
the meaning hereof.

          (g) Governing Law. This Agreement shall be governed by and
construed in accordance with the laws of the State of New York
applicable to contracts made and to be performed wholly within that
State.

          (h) Severability. In the event that any one or more of the
provisions contained herein, or the application thereof in any
circumstances, is held invalid, illegal or unenforceable in any
respect for any reason, the validity, legality and enforceability of
any such provision in every other respect and of the remaining
provisions contained herein shall not be in any way impaired thereby,
it being intended that all remaining provisions contained herein shall
not be in any way impaired thereby, it being intended that all of the
rights and privileges of the Shareholders shall be enforceable to the
fullest extent permitted by law.

          (i) Entire Agreement. This Agreement is intended by the
parties as a final expression and a complete and exclusive statement
of the agreement and understanding of the parties hereto in respect of
the subject matter hereof. There are no restrictions, promises,
warranties or


<PAGE>


undertakings with respect to the subject matter hereof, other than
those set forth or referred to herein and therein. This Agreement
supersedes all prior agreements and understandings between the parties
with respect to such subject matter.


          IN WITNESS WHEREOF, the parties have executed this Agreement
as of the date first written above.

                                         BRISTOL-MYERS SQUIBB COMPANY,

                                           by
                                              /s/ George P. Kooluris
                                            -----------------------------
                                             Name:  George P. Kooluris
                                             Title:  Senior Vice President,
                                                     Corporate Development


                                               /s/ Sydell L. Miller
                                             ------------------------------
                                             Sydell L. Miller


                                               /s/ Sydell L. Miller
                                             ------------------------------
                                             Sydell L. Miller, as
                                             Executrix for and on
                                             behalf of the Estate of
                                             Arnold M. Miller


                                              /s/ Lauren Miller Spilman
                                             ------------------------------
                                             Lauren Miller Spilman


                                              /s/ Stacie Miller Halpern
                                             ------------------------------
                                             Stacie Miller Halpern


<PAGE>

        /s/ Robert G. Markey  
       -----------------------------
       Robert G. Markey, as Trustee for and on behalf of each of the
       following Trusts:

       Sydell L. Miller Dynasty Trust for the benefit of Lauren Miller
            Spilman u/a dated 8/26/93 
       Sydell L. Miller Dynasty Trust
            for the benefit of Stacie Miller Halpern u/a dated 8/26/93
       Arnold M. Miller and Sydell L. Miller Trust for the
            benefit of Lauren Miller Spilman u/a dated 12/30/91 
       Arnold M. Miller and Sydell L. Miller Trust for the benefit of
            Stacie Miller Halpern u/a dated 12/30/91 
       Sydell Miller Income Trust for the benefit of Sydell Miller u/a dated
            7/31/90 
       Arnold M. Miller Irrevocable Trust for the benefit
            of Lauren Miller Spilman u/a dated 12/28/83 Arnold M.
            Miller Irrevocable Trust for the benefit of Stacie Miller
            Halpern u/a dated 12/28/83 
       Arnold M. Miller Included Marital Trust for the benefit 
            of Sydell L. Miller u/a dated 7/6/78 
       Arnold M. Miller GST Exempt Trust for the benefit of 
            Lauren Miller Spilman u/a dated 7/6/78 
       Arnold M. Miller GST Exempt Trust for the benefit of 
            Stacie Miller Halpern u/a dated 7/6/78


         /s/ Dennis Lubin
       --------------------------
       Dennis Lubin, as Trustee for and on behalf of each of
       the following Trusts:

       Sydell L. Miller Dynasty Trust for the benefit of
            Lauren Miller Spilman u/a dated 8/26/93
       Sydell L. Miller Dynasty Trust for the benefit of Stacie
            Miller Halpern u/a dated 8/26/93
       Arnold M. Miller Included Marital Trust for the benefit
            of Sydell L. Miller u/a dated 7/6/78
       Arnold M. Miller GST Exempt Trust for the benefit of
            Lauren Miller Spilman u/a dated 7/6/78
       Arnold M. Miller GST Exempt Trust for the benefit of
            Stacie Miller Halpern u/a dated 7/6/78

<PAGE>

        /s/ Sydell L. Miller
       --------------------------
       Sydell L. Miller, as Trustee for and on behalf of each
       of the following Trusts:

       Arnold M. Miller Included Marital Trust for the benefit
            of Sydell L. Miller u/a dated 7/6/78
       Lauren Miller (now Spilman) Trust for the benefit of
            Lauren Miller Spilman u/a dated 7/11/89
       Stacie Miller (now Halpern) Trust for the benefit of
            Stacie Miller Halpern u/a dated 7/11/89


<PAGE>


        /s/ David A. Cook
       --------------------------
       David A. Cook


        /s/ Robert M. Diemer
       --------------------------
       Robert M. Diemer


        /s/ Jeffrey J. Kunz
       --------------------------
       Jeffrey J. Kunz



        /s/ Dennis E. Lubin
       --------------------------
       Dennis E. Lubin


        /s/ Robert G. Markey
       --------------------------
       Robert G. Markey


        /s/ D. Scott Miller
       --------------------------
       D. Scott Miller



        /s/ Robert C. Miller
       --------------------------
       Robert C. Miller


<PAGE>

                             SHAREHOLDERS                    SCHEDULE I

1. David A. Cook                    12.  Sydell L. Miller Dynasty Trust
   36341 Blue Grass Oval                 for the benefit of Stacie
   Solon, OH 44139                       Miller Halpern u/a dated
                                         8/26/93
2. Stacie Miller Halpern                 3200 National City Center
   140 Cyrstal Lane                      Cleveland, OH 44114
   Aurora, OH 44202

3. Jeffrey J. Kunz                  13.  Arnold M. Miller and Sydell L.
   2432 Channing Road                    Miller Trust for the benefit
   University Heights, OH 44118          of Lauren Miller Spilman u/a
                                         dated 12/30/91
4. Dennis E. Lubin                       3200 National City Center
   180 Glen Road                         Cleveland, OH 44114
   Moreland Hills, OH 44122
                                    14.  Arnold M. Miller and Sydell L.  
5. Robert G. Markey                      Miller Trut for the Benefit
   27925 Belgrave Road                   of Stacie Miller Halpern u/a
   Pepper Pike, OH 44124                 dated 12/30/91
                                         3200 natioal City Center
6. D. Scott Miller                       Cleveland, OH 44114
   4588 Copley-Sharon Road
   Copley, OH 44321                 15.  Sydell Miller Income Trust for
                                         the benefit of Sydell Miller
7. Robert C. Miller                      u/a dated 7/31/90
   2156 White Marsh Drive                3200 National City Center
   Twinsburg, OH 44087                   Cleveland, OH 44114

8. Sydell L. Miller                 16.  Arnold M. Miller Irrevocable
   25119 Wimbledon Road                  Trust for the benefit of
   Beachwood, OH 44122                   Lauren Miller Spilman u/a
                                         dated 12/28/83
9. Lauren Miller Spilman                 3200 National City Center
   311 High Bluff Court                  Cleveland, OH 44114
   Aurora, OH 44202
                                     17.  Arnold M. Miller Irrevocable
10. Robert M. Diemer                      Trust for the benefit of 
    10499 White Ash Trail                 Stacie Miller Halpern u/a
    Twinsburg, OH 44087                   dated 12/28/83
                                          3200 National City Center
11. Sydell L. Miller Dynasty Trust        Cleveland, OH 44114
    for the benefit of
    Lauren Miller Spilman u/a        18.  Arnold M. Miller Included   
    dated 8/26/93                         Marital Trust for the benefit
    3200 National City Center             of Sydell L. Miller u/a dated
    Cleveland, OH 44114                   7/6/78
                                          3200 National City Center
                                          Cleveland, OH 44114


<PAGE>



19. Lauren Miller (now Spilman)
    Trust for the benefit of
    Lauren Miller Spilman u/a
    dated 7/11/89
    25119 Wimbledon Road
    Beachwood, OH 44122

20. Stacie Miller (now Halpern)
    Trust for the benefit of
    Stacie Miller Halpern u/a
    dated 7/11/89
    25119 Wimbledon Road
    Beachwood, OH 44122

21. Arnold M. Miller GST Exempt
    Trust for the benefit of
    Lauren Miller Spilman u/a
    dated 7/6/78
    3200 National City Center
    Cleveland, OH 44114

22. Arnold M. Miller GST Exempt
    Trust for the benefit of
    Stacie Miller Halpern u/a
    dated 7/6/78
    3200 National City Center
    Cleveland, OH 44114

23. Estate of Arnold M. Miller
    25119 Wimbledon Road
    Beachwood, OH 44122



                                                             EXHIBIT 5


                           [LETTERHEAD OF]


                       Cravath, Swaine & Moore



                                                         July 20, 1995


                     Bristol-Myers Squibb Company
                Common Stock, Par Value $.10 Per Share


Dear Sirs:

          We have acted as special counsel for Bristol-Myers Squibb
Company, a Delaware corporation (the "Company"), in connection with
the Registration Statement on Form S-3 (the "Registration Statement")
being filed by the Company on the date hereof with the Securities and
Exchange Commission under the Securities Act of 1933 with respect to
the proposed shelf registration of 2,500,000 shares of common stock,
par value $.10 per share, of the Company (the "Shares").

          In connection with the foregoing, we have examined
originals, or copies certified or otherwise identified to our
satisfaction, of such documents, corporate records and other
instruments as we have deemed necessary or appropriate for the purpose
of this opinion.

          Based upon the foregoing, we are of opinion that the Shares
are validly authorized and are legally issued, fully paid and
nonassessable.

          We know that we are referred to under the heading "Validity
of the Securities" in Registration Statement, and we consent to such
use of our name in the Registration


<PAGE>


Statement and to the use of this opinion for filing as an exhibit to
the Registration Statement.


                                   Very truly yours,




                                  Cravath, Swaine & Moore


Bristol-Myers Squibb Company
  345 Park Avenue
    New York, NY 10154-0037

37A



                                                          EXHIBIT 23.2








                  CONSENT OF INDEPENDENT ACCOUNTANTS



We hereby consent to the incorporation by reference in the Prospectus
constituting part of this Registration Statement on Form S-3 of our
report dated January 19, 1995 appearing on page 50 of Bristol-Myers
Squibb Company's Annual Report on Form 10-K for the year ended
December 31, 1994. We also consent to the reference to under the
heading "Experts" in such Prospectus.




PRICE WATERHOUSE LLP





New York, New York
July 18, 1995






                                                            Exhibit 24


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.



                                Signed: /s/  Charles A. Heimbold, Jr.
                                        -----------------------------
                                        Charles A. Heimbold, Jr.


<PAGE>


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.


                                    Signed: /s/  Robert E. Allen
                                           -----------------------------
                                           Robert E. Allen


<PAGE>


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.


                                       Signed: /s/  Michael E. Autera
                                               -------------------------
                                               Michael E. Autera

<PAGE>


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.


Dated this 17th day of July, 1995.

                                        Signed: /s/  Ellen V. Futter
                                               -----------------------
                                               Ellen V. Futter



<PAGE>


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.

                                       Signed: /s/  Louis V. Gerstner, Jr.
                                               ---------------------------
                                               Louis V. Gerstner, Jr.


<PAGE>

                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.


Dated this 17th day of July, 1995.

                                          Signed: /s/  John D. Macomber
                                                 -----------------------
                                                 John D. Macomber


<PAGE>

                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.


Dated this 17th day of July, 1995.

                                          Signed: /s/  John D. Macomber
                                                 -----------------------
                                                 John D. Macomber


<PAGE>
                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.



                                       Signed: /s/  James D. Robinson III
                                               ---------------------------
                                                James D. Robinson III

<PAGE>


                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.


                                         Signed: /s/  Louis W. Sullivan, M.D.
                                                -----------------------------
                                                 Louis W. Sullivan, M.D.



<PAGE>

                          POWER OF ATTORNEY



          The undersigned certifies that he is a Director of
Bristol-Myers Squibb Company.

          The undersigned hereby appoints each of A. C. Brennan and J.
L. McGoldrick as his attorneys-in-fact, each with the power of
substitution, to execute, on his behalf the foregoing Registration
Statement on Form S-3, for filing with the Securities and Exchange
Commission ("SEC"), and to execute any and all amendments to said
registration statement, and to do all such other acts and execute all
such other documents which said attorneys may deem necessary or
desirable.



Dated this 17th day of July, 1995.



                                        Signed: /s/  Kenneth E. Weg
                                                -------------------
                                                 Kenneth E. Weg





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