BRISTOL MYERS SQUIBB CO
424B5, 1996-11-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                                                               RULE 424(b)(5)
                                                               REG. NO. 33-62496




             PROSPECTUS SUPPLEMENT TO PROSPECTUS DATED MAY 20, 1993
 
                                  $350,000,000
                          BRISTOL-MYERS SQUIBB COMPANY
                     6.80% DEBENTURES DUE NOVEMBER 15, 2026
- --------------------------------------------------------
     Interest  on the Debentures  is payable on  May 15 and  November 15 of each
year, commencing  May 15,  1997.  The Debentures  are  not redeemable  prior  to
maturity  and  are not  entitled to  any  sinking fund.  The Debentures  will be
represented by  one or  more global  securities registered  in the  name of  the
nominee  of The  Depository Trust  Company. Beneficial  interests in  the global
securities will  be  shown on,  and  transfers  thereof will  be  effected  only
through,  records maintained  by DTC and  its participants.  Except as described
herein, Debentures in definitive form will not be issued. The Debentures will be
issued only  in denominations  of  $1,000 and  integral multiples  thereof.  See
'Description of Debentures'.
 
                             ---------------------
THESE  SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION  OR  ANY STATE  SECURITIES  COMMISSION NOR  HAS  THE
     SECURITIES   AND   EXCHANGE   COMMISSION  OR   ANY   STATE  SECURITIES
       COMMISSION  PASSED  UPON   THE  ACCURACY  OR   ADEQUACY  OF   THIS
         PROSPECTUS  SUPPLEMENT OR THE PROSPECTUS  TO WHICH IT RELATES.
           ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL  OFFENSE.
 
                             ---------------------
 
<TABLE>
<CAPTION>
                                                            INITIAL PUBLIC      UNDERWRITING    PROCEEDS TO
                                                          OFFERING PRICE(1)     DISCOUNT(2)    COMPANY(1)(3)
                                                          ------------------    -----------    -------------
 
<S>                                                       <C>                   <C>            <C>
Per Debenture.........................................         98.866%             0.45%          98.416%
Total.................................................       $346,031,000       $1,575,000     $344,456,000
</TABLE>
 
- ------------
(1) Plus accrued interest, if any, from November 15, 1996.
(2) The  Company  has  agreed  to  indemnify  the  Underwriters  against certain
    liabilities, including liabilities under the Securities Act of 1933.
(3) Before deducting estimated expenses of $285,000 payable by the Company.
 
                             ---------------------
     The Debentures offered hereby are offered severally by the Underwriters, as
specified herein, subject to receipt and acceptance by them and subject to their
right to  reject  any order  in  whole  or in  part.  It is  expected  that  the
Debentures  will  be ready  for  delivery in  book-entry  form only  through the
facilities of DTC in New York, New York, on or about November 15, 1996,  against
payment therefor in immediately available funds.
 
GOLDMAN, SACHS & CO.
          ABN AMRO SECURITIES (USA) INC.
                      CHASE SECURITIES INC.
                                  PAINEWEBBER INCORPORATED
                                              PRUDENTIAL SECURITIES INCORPORATED
                             ---------------------
          The date of this Prospectus Supplement is November 12, 1996.


<PAGE>
<PAGE>

     IN  CONNECTION WITH THE OFFERING, THE UNDERWRITERS MAY OVER-ALLOT OR EFFECT
TRANSACTIONS WHICH  STABILIZE OR  MAINTAIN THE  MARKET PRICE  OF THE  DEBENTURES
OFFERED  HEREBY AT A LEVEL ABOVE THAT  WHICH MIGHT OTHERWISE PREVAIL IN THE OPEN
MARKET. SUCH STABILIZING, IF COMMENCED, MAY BE DISCONTINUED AT ANY TIME.
 
                            ------------------------
 
                           DESCRIPTION OF DEBENTURES
 
     The  Debentures  are  a  series   of  Debt  Securities  described  in   the
accompanying  Prospectus and will be limited to $350,000,000 aggregate principal
amount. The Debentures  will mature on  November 15, 2026.  Reference should  be
made  to  the  accompanying  Prospectus for  a  detailed  summary  of additional
provisions of the Debentures and of the Indenture dated as of June 1, 1993  (the
'Indenture'), between Bristol-Myers Squibb Company (the 'Company') and The Chase
Manhattan  Bank (National Association), as  trustee (the 'Trustee'), under which
the Debentures are issued.
 
INTEREST
 
     Interest on the Debentures at the annual  rate set forth on the cover  page
of this Prospectus Supplement will accrue from November 15, 1996, and is payable
on  May 15 and November 15 of each year, commencing May 15, 1997, to the persons
in whose names the  Debentures are registered  at the close  of business on  the
next preceding May 1 and November 1.
 
REDEMPTION
 
     The Debentures are not redeemable prior to maturity and are not entitled to
any sinking fund.
 
BOOK-ENTRY SYSTEM
 
     The  Debentures  initially  will  be  represented  by  one  or  more global
securities (the 'Global Securities') deposited with The Depository Trust Company
('DTC') and registered  in the name  of a nominee  of DTC. Except  as set  forth
below, the Debentures will be available for purchase in denominations of $1,000,
and integral multiples thereof, in book-entry form only.
 
     Unless  and  until certificated  Debentures  are issued  under  the limited
circumstances described  below, no  beneficial  owner of  a Debenture  shall  be
entitled  to receive a definitive certificate  representing a Debenture. So long
as DTC or  any successor  depository (the 'Depository')  or its  nominee is  the
registered  owner of all the Global  Securities, the Depository or such nominee,
as the case may  be, will be considered  to be the sole  owner or holder of  the
Debentures  for all  purposes of  the Indenture.  Unless and  until exchanged in
whole or in part for the  Debentures represented thereby, the Global  Securities
may  not be transferred except in their  entirety by the Depository to a nominee
of the Depository  or by  a nominee  of such  Depository to  such Depository  or
another  nominee of  such Depository or  by the  Depository or any  nominee to a
successor depository or any nominee of such successor.
 
     So long as the Debentures are represented by Global Securities, payments of
interest and principal will  be made to  the Depository or  its nominee, as  the
registered  owner of the Global Securities. Payments to beneficial owners of the
Debentures are expected  to be made  through the Depository  or its nominee,  as
described  in the  Prospectus under  'Description of  Debt Securities  -- Global
Securities'. None of the Company, the Trustee, any paying agent or the  security
registrar  will  have any  responsibility  or liability  for  any aspect  of the
records relating  to,  or payments  made  on account  of,  beneficial  ownership
interests  in  the  Global Securities  for  the Debentures  or  for maintaining,
supervising or reviewing any records relating to such beneficial interests.
 
     If the  Depository  is at  any  time  unwilling, unable  or  ineligible  to
continue  as  depository and  a  successor depository  is  not appointed  by the
Company within  90  days,  the  Company  will  issue  individual  Debentures  in
definitive   form  in  exchange  for  the  Global  Securities  representing  the
Debentures. In addition, the Company may at any time and in its sole  discretion
determine  not to have the Debentures  represented by Global Securities, and, in
such event, will issue individual Debentures in definitive form in exchange  for
the  Global Securities. In either instance, the Company will issue Debentures in
definitive form, equal in aggregate  principal amount to the Global  Securities,
in such names and in such
 
                                      S-2
 

<PAGE>
<PAGE>


principal  amounts  as the  Depository shall  request.  Debentures so  issued in
definitive form will be issued in denominations of $1,000 and integral multiples
thereof and will be issued in registered form only, without coupons.
 
     DTC is a  limited-purpose trust  company organized  under the  laws of  the
State  of New York, a 'banking organization'  within the meaning of the New York
banking law, a member  of the Federal Reserve  System, a 'clearing  corporation'
within  the meaning  of the  New York  Uniform Commercial  Code and  a 'clearing
agency' registered pursuant to the provisions  of Section 17A of the  Securities
Exchange Act of 1934. DTC was created to hold securities of its participants and
to  facilitate the clearance and settlement of securities transactions among its
participants  in  such  securities  through  electronic  book-entry  changes  in
accounts of the participants, thereby eliminating the need for physical movement
of  securities certificates.  DTC's participants include  securities brokers and
dealers (including  the  Underwriters),  banks (including  the  Trustee),  trust
companies,  clearing corporations and certain other organizations, some of which
(and/or their representatives)  own DTC.  Access to DTC's  book-entry system  is
also  available to others,  such as banks, brokers,  dealers and trust companies
that clear  through or  maintain a  custodial relationship  with a  participant,
either  directly or indirectly. The rules applicable to DTC and its participants
are on file with the Securities and Exchange Commission.
 
GENERAL
 
     Other  than  certain   restrictions  on  Liens   and  Sale  and   Leaseback
Transactions  described in  the accompanying  Prospectus, the  Indenture and the
Debentures do not contain any 'event risk' covenants designed to afford  holders
of the Debentures protection in the event of a recapitalization, merger or other
transaction  (leveraged or otherwise)  involving the Company,  its management or
its affiliates.
 
                                  UNDERWRITING
 
     Subject  to  the  terms  and  conditions  set  forth  in  the  Underwriting
Agreement,  the Company  has agreed  to sell to  each of  the Underwriters named
below, and each such Underwriter has severally agreed to purchase, the principal
amount of the Debentures set forth opposite its name below:
 
<TABLE>
<CAPTION>
                                                                                                      PRINCIPAL
                                                                                                        AMOUNT
                                                                                                          OF
                                           UNDERWRITER                                                DEBENTURES
- --------------------------------------------------------------------------------------------------   ------------
<S>                                                                                                  <C>
Goldman, Sachs & Co...............................................................................   $190,000,000
Chase Securities Inc..............................................................................     50,000,000
Prudential Securities Incorporated................................................................     50,000,000
PaineWebber Incorporated..........................................................................     35,000,000
ABN AMRO Securities (USA) Inc.....................................................................     25,000,000
                                                                                                     ------------
       Total......................................................................................   $350,000,000
                                                                                                     ------------
                                                                                                     ------------
</TABLE>
 
     Under  the  terms  and  conditions  of  the  Underwriting  Agreement,   the
Underwriters are committed to take and pay for all of the Debentures, if any are
taken.
 
     The  Underwriters propose to  offer the Debentures in  part directly to the
public at the initial public offering price set forth on the cover page of  this
Prospectus  and  in part  to certain  securities  dealers at  such price  less a
concession of 0.35% of the principal amount of the Debentures. The  Underwriters
may allow, and such dealers may reallow, a concession not to exceed 0.25% of the
principal  amount of  the Debentures to  certain brokers and  dealers. After the
Debentures are released  for sale to  the public, the  offering price and  other
selling terms may from time to time be varied by the Underwriters.
 
     The  Debentures are a  new issue of securities  with no established trading
market. The Company has been advised  by the Underwriters that the  Underwriters
intend to make a market in the Debentures but are not obligated to do so and may
discontinue  market making at any time without notice. No assurance can be given
as to the liquidity of the trading market of the Debentures.
 
     An affiliate of Chase Securities Inc. has in the past and may in the future
engage in  general  financing and  banking  transactions with  the  Company  and
certain  of its affiliates.  In addition, the  Trustee is an  affiliate of Chase
Securities Inc.
 
     The Company  has  agreed  to indemnify  the  several  Underwriters  against
certain liabilities, including liabilities under the Securities Act of 1933.
 
                                      S-3
 

<PAGE>
<PAGE>
                       RATIO OF EARNINGS TO FIXED CHARGES
 
     For  purposes  of  computing  the  ratio  of  earnings  to  fixed  charges,
'earnings' consist of  income from  continuing operations  before provision  for
income  taxes  and fixed  charges (excluding  capitalized interest),  and 'fixed
charges'  consist  of  interest  and  debt  expense,  capitalized  interest  and
one-third  of  rental  expense  (which  the  Company  believes  is  a reasonable
approximation of the interest factor of such rental expense).
 
     The following table sets forth the  ratio of earnings to fixed charges  for
the  Company for each of  the periods indicated (in  millions of dollars, except
ratio amounts):
 
<TABLE>
<CAPTION>
                                NINE MONTHS                      YEAR ENDED DECEMBER 31,
                                   ENDED            --------------------------------------------------
                             SEPTEMBER 30, 1996      1995       1994       1993       1992       1991
                             ------------------     ------     ------     ------     ------     ------
 
<S>                          <C>                    <C>        <C>        <C>        <C>        <C>
Earnings:
  Earnings from continuing
     operations before
     income taxes                  $3,005           $2,402     $2,555     $2,571     $1,987     $2,784
  Fixed charges                        99              157        128        118        109        114
  Capitalized interest                (11)             (15)       (15)       (14)       (13)       (12)
                                  -------           ------     ------     ------     ------     ------
     Total earnings                $3,093           $2,544     $2,668     $2,675     $2,083     $2,886
                                  -------           ------     ------     ------     ------     ------
                                  -------           ------     ------     ------     ------     ------
Fixed Charges:
  Interest and debt expense        $   54           $   97     $   68     $   57     $   49     $   55
  Capitalized interest                 11               15         15         14         13         12
  One-third of rental
     expense                           34               45         45         47         47         47
                                  -------           ------     ------     ------     ------     ------
     Total fixed charges           $   99           $  157     $  128     $  118     $  109     $  114
                                  -------           ------     ------     ------     ------     ------
                                  -------           ------     ------     ------     ------     ------
Ratio of earnings to fixed
  charges                           31.24            16.20(a)   20.84(b)   22.67(c)   19.11(d)   25.32
                                  -------           ------     ------     ------     ------     ------
                                  -------           ------     ------     ------     ------     ------
</TABLE>
 
- ------------
 
 (a) Earnings in 1995 reflect a $950 million charge before taxes for pending and
     future product liability claims and a $310 million charge before taxes  for
     restructuring.  Excluding  this  charge,  the ratio  of  earnings  to fixed
     charges for 1995 would have been 24.23.
 
 (b) Earnings in 1994 reflect a $750 million charge before taxes for pending and
     future product  liability  claims.  Excluding this  charge,  the  ratio  of
     earnings to fixed charges for 1994 would have been 26.70.
 
 (c) Earnings in 1993 reflect a $500 million charge before taxes for pending and
     future  product  liability  claims.  Excluding this  charge,  the  ratio of
     earnings to fixed charges for 1993 would have been 26.91.
 
 (d) Earnings  in  1992  reflect  an  $890  million  charge  before  taxes   for
     restructuring.  Excluding  this  charge,  the ratio  of  earnings  to fixed
     charges for 1992 would have been 27.28.
 
                                      S-4
<PAGE>
<PAGE>
 
PROSPECTUS
 
                          BRISTOL-MYERS SQUIBB COMPANY
                                DEBT SECURITIES
 
     Bristol-Myers  Squibb Company (the 'Company') may  offer from time to time,
in one  or  more series,  its  debt securities  (the  'Debt Securities')  at  an
aggregate initial offering price not to exceed $1,000,000,000, or the equivalent
thereof if any Debt Securities are denominated in one or more foreign currencies
or  units based on or related to currencies. The Debt Securities may be sold for
U.S. dollars or one or more foreign  currencies or units based on or related  to
currencies,  and the principal  of and any  interest on the  Debt Securities may
likewise be payable in U.S. dollars or  one or more foreign currencies or  units
based on or related to currencies.
 
     The  Debt Securities will be  offered to the public  on terms determined by
the Company  in  light of  market  conditions at  the  time of  sale.  The  Debt
Securities  may  be  issued in  one  or more  series  with the  same  or various
maturities, at par  or at a  premium or  with original issue  discount, and  may
include medium-term notes. The specific designation, aggregate principal amount,
currency (or units based on or related to currencies), authorized denominations,
purchase  price or  prices, maturity  or maturities, rate  or rates  and time of
payment of  any interest,  any terms  for optional  or mandatory  redemption  or
repayment  or  any sinking  fund provisions,  any other  specific terms  and any
listing on a  securities exchange of  Debt Securities in  respect of which  this
Prospectus  is  being delivered  are set  forth  in the  accompanying prospectus
supplement (the 'Prospectus Supplement'), together with the terms of offering of
such Debt Securities.
 
     The Debt Securities may be issued only in registered form, including in the
form of one or  more global securities  ('Global Securities'), unless  otherwise
set forth in the Prospectus Supplement.
 
                            ------------------------
 
THESE  SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION  OR ANY  STATE SECURITIES  COMMISSION NOR  HAS  THE
      SECURITIES   AND  EXCHANGE  COMMISSION  OR  ANY  STATE  SECURITIES
        COMMISSION PASSED  UPON  THE  ACCURACY OR  ADEQUACY  OF  THIS
              PROSPECTUS.  ANY  REPRESENTATION  TO  THE  CONTRARY
                           IS A CRIMINAL OFFENSE.
 
                 ----------------------------------------------------------
 
     The Debt Securities may be offered directly, through agents designated from
time to time, to or through underwriters or dealers or through a combination  of
such  methods. See 'Plan of  Distribution'. If any agents  of the Company or any
underwriters are involved in the sale of the Debt Securities, the names of  such
agents or underwriters and any applicable commissions or discounts are set forth
in the Prospectus Supplement. The net proceeds to the Company from such sale are
also set forth in the Prospectus Supplement.
 
                            ------------------------
 
                  THE DATE OF THIS PROSPECTUS IS MAY 20, 1993.


<PAGE>
<PAGE>
     NO  PERSON  HAS BEEN  AUTHORIZED TO  GIVE  ANY INFORMATION  OR TO  MAKE ANY
REPRESENTATIONS NOT CONTAINED IN THIS PROSPECTUS OR THE PROSPECTUS SUPPLEMENT IN
CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND THE PROSPECTUS  SUPPLEMENT
AND,  IF GIVEN OR MADE,  SUCH INFORMATION OR REPRESENTATIONS  MUST NOT BE RELIED
UPON AS HAVING BEEN AUTHORIZED BY THE  COMPANY OR BY ANY UNDERWRITER, DEALER  OR
AGENT.  THIS PROSPECTUS AND THE PROSPECTUS SUPPLEMENT DO NOT CONSTITUTE AN OFFER
TO SELL OR A SOLICITATION OF AN OFFER TO BUY ANY OF THE DEBT SECURITIES  OFFERED
HEREBY  IN ANY JURISDICTION  TO ANY PERSON TO  WHOM IT IS  UNLAWFUL TO MAKE SUCH
OFFER OR SOLICITATION IN SUCH  JURISDICTION. THIS PROSPECTUS AND THE  PROSPECTUS
SUPPLEMENT  DO NOT CONSTITUTE AN OFFER TO SELL  OR A SOLICITATION OF AN OFFER TO
BUY ANY SECURITIES OTHER THAN THOSE  TO WHICH THEY RELATE. NEITHER THE  DELIVERY
OF  THIS PROSPECTUS AND  THE PROSPECTUS SUPPLEMENT  NOR ANY SALE  OF OR OFFER TO
SELL THE DEBT SECURITIES OFFERED  HEREBY SHALL, UNDER ANY CIRCUMSTANCES,  CREATE
AN IMPLICATION THAT THERE HAS BEEN NO CHANGE IN THE AFFAIRS OF THE COMPANY SINCE
THE  RESPECTIVE DATES OF  THIS PROSPECTUS AND THE  PROSPECTUS SUPPLEMENT OR THAT
THE INFORMATION IN THIS PROSPECTUS OR THE PROSPECTUS SUPPLEMENT IS CORRECT AS OF
ANY TIME  SUBSEQUENT  TO  THE  RESPECTIVE  DATES  OF  THIS  PROSPECTUS  AND  THE
PROSPECTUS SUPPLEMENT.
 
                             AVAILABLE INFORMATION
 
     The  Company is subject to the informational requirements of the Securities
Exchange Act of  1934 (the 'Exchange  Act'), and in  accordance therewith  files
reports, proxy statements and other information with the Securities and Exchange
Commission   (the  'Commission').  Such  reports,  proxy  statements  and  other
information  filed  by  the  Company   with  the  Commission  pursuant  to   the
informational  requirements of the  Exchange Act can be  inspected and copied at
the public  reference facilities  maintained  by the  Commission at  Room  1024,
Judiciary  Plaza, 450  Fifth Street,  N.W., Washington,  D.C. 20549,  and at the
following Regional Offices of the Commission: New York Regional Office, 7  World
Trade  Center, 13th Floor, New York, New York 10048 and Chicago Regional Office,
Northwestern Atrium  Center,  500  West Madison  Street,  Suite  1400,  Chicago,
Illinois  60661.  Copies of  such  material can  also  be obtained  upon written
request addressed to  the Securities and  Exchange Commission, Public  Reference
Section, Room 1024, 450 Fifth Street, N.W., Washington, D.C. 20549 at prescribed
rates.  Such  reports,  proxy  statements  and  other  information  can  also be
inspected at the offices of  the New York Stock  Exchange, 20 Broad Street,  New
York, New York 10005, and at the offices of the Pacific Stock Exchange, 301 Pine
Street,  San  Francisco, California  94104, on  which  certain of  the Company's
securities are listed.
 
     This Prospectus  forms a  part  of a  registration  statement on  Form  S-3
(referred to herein, including all amendments and exhibits, as the 'Registration
Statement')  which the Company has  filed under the Securities  Act of 1933 (the
'Securities Act') with respect to the Debt Securities. This Prospectus does  not
contain  all the information otherwise set  forth in the Registration Statement,
certain parts of which are omitted in accordance with the rules and  regulations
of   the  Commission.  For  further  information,   reference  is  made  to  the
Registration Statement and the exhibits filed as part thereof. The  Registration
Statement  may be inspected at the public reference facilities maintained by the
Commission at the  addresses set  forth in the  preceding paragraph.  Statements
contained herein concerning any document filed as an exhibit to the Registration
Statement  are not necessarily complete and, in each instance, reference is made
to the copy of such document filed as an exhibit to the Registration  Statement.
Each such statement is qualified in its entirety by such reference.
 
                      DOCUMENTS INCORPORATED BY REFERENCE
 
     The  Company hereby incorporates by reference its (i) Annual Report on Form
10-K for the fiscal year ended December  31, 1992, and (ii) Quarterly Report  on
Form  10-Q for the  fiscal quarter ended  March 31, 1993,  which have been filed
with the Commission pursuant to the Exchange Act (File No. 1-1136).
 
     All documents filed by the Company pursuant to Section 13(a), 13(c), 14  or
15(d)  of the Exchange Act after the date hereof and prior to the termination of
the offering  of  the Debt  Securities  offered hereby  shall  be deemed  to  be
incorporated by reference herein and to be a part hereof from the date of filing
of such documents.
 
                                       2
 

<PAGE>
<PAGE>
     Any  statement  contained  in  a  document  incorporated  or  deemed  to be
incorporated by reference herein  shall be deemed to  be modified or  superseded
for purposes of this Prospectus and the Prospectus Supplement to the extent that
a  statement contained herein  or in any other  subsequently filed document that
also is  or  is  deemed to  be  incorporated  by reference  herein  modifies  or
supersedes  such statement. Any  such statement so  modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this
Prospectus or the Prospectus Supplement.
 
     The Company  will furnish  without  charge to  each person,  including  any
beneficial  owner,  to whom  this Prospectus  and  the Prospectus  Supplement is
delivered, upon written or oral  request of such person, a  copy of any and  all
documents  incorporated  herein by  reference  (not including  exhibits  to such
documents, unless such exhibits are specifically incorporated by reference  into
such  documents). Requests should  be directed to  Bristol-Myers Squibb Company,
345 Park  Avenue, New  York,  New York  10154, Attention:  Secretary  (telephone
number: (212) 546-4000).
 
                          BRISTOL-MYERS SQUIBB COMPANY
 
     The   Company  is  a  worldwide   organization  engaged  primarily  in  the
manufacture and  sale  of a  broad  range of  pharmaceutical  products,  medical
devices,  nonprescription health  products and  toiletries and  beauty aids. The
Company's principal business segments  are: Pharmaceutical Products,  consisting
of   prescription   medicines,  primarily   cardiovascular  drug   products  and
anti-infective, anti-cancer and central nervous system drugs, diagnostic  agents
and  other pharmaceutical  products; Medical Devices,  consisting of orthopaedic
implants, ostomy and wound care products, surgical instruments and other medical
devices; Nonprescription  Health Products,  consisting  of infant  formulas  and
other  nutritional  products,  analgesics,  cough/cold  remedies  and  skin care
products; and Toiletries and  Beauty Aids, consisting  of haircoloring and  hair
care preparations, deodorants, anti-perspirants and beauty appliances.
 
     All  references herein to the  Company include Bristol-Myers Squibb Company
and its subsidiaries, unless the context otherwise requires.
 
     The principal executive  offices of  the Company  are located  at 345  Park
Avenue, New York, New York 10154. Its telephone number is (212) 546-4000.
 
     Recent  Developments.  In April  of  1993, the  Board  of Directors  of the
Company authorized the purchase by the Company,  from time to time, of up to  25
million  shares of the Company's common stock  (in addition to 25 million shares
which the Board of Directors of the Company had, in 1987, authorized the Company
to purchase, of which approximately 21.7 million shares had been purchased as of
May 6, 1993) to  cover commitments under outstanding  and future stock  options,
preferred  stock  conversions and  warrant exercises  and for  general corporate
purposes.
 
                       RATIO OF EARNINGS TO FIXED CHARGES
 
     The following table sets forth the  ratio of earnings to fixed charges  for
the Company for each of the periods indicated:
 
<TABLE>
<CAPTION>
 THREE MONTHS                 YEAR ENDED DECEMBER 31,
    ENDED          ---------------------------------------------
MARCH 31, 1993     1992      1991      1990      1989      1988
- --------------     -----     -----     -----     -----     -----
 <S>                <C>       <C>       <C>       <C>       <C>
     27.69         19.11*    25.32     22.78     10.72**   16.36
</TABLE>
 
- ------------
 
*  Earnings   in  1992  reflect   an  $890  million   charge  before  taxes  for
   restructuring. Excluding this charge, the ratio of earnings to fixed  charges
   for 1992 would have been 27.28.
 
** Earnings  in 1989 reflect an $855 million charge before taxes for integrating
   businesses and other expenses related to the merger of Bristol-Myers  Company
   and Squibb Corporation. Excluding this charge, the ratio of earnings to fixed
   charges for 1989 would have been 17.84.
 
                            ------------------------
     For  purposes  of  computing  the  ratio  of  earnings  to  fixed  charges,
'earnings' consist of  income from  continuing operations  before provision  for
income taxes and fixed charges (excluding capitalized
 
                                       3
 

<PAGE>
<PAGE>
interest), and 'fixed charges' consist of interest and debt expense, capitalized
interest  and  one-third of  rental  expense (which  the  Company believes  is a
reasonable approximation of the interest factor of such rental expense).
 
                                USE OF PROCEEDS
 
     Unless otherwise  indicated  in  the  Prospectus  Supplement,  the  Company
intends  to  use the  net proceeds  to be  received  from the  sale of  the Debt
Securities offered hereby  for general  corporate purposes,  which may  include,
without  limitation,  working  capital,  capital  expenditures,  stock  purchase
programs, repayment and refinancing of  borrowings, and acquisitions. Funds  not
required  immediately for such purposes may be invested in marketable securities
and short-term investments.
 
                         DESCRIPTION OF DEBT SECURITIES
 
     The Debt Securities will be unsecured obligations of the Company issued  in
one  or more series under an indenture (the 'Indenture') between the Company and
The Chase Manhattan Bank (National Association), as trustee (the 'Trustee'), the
form of which is filed as an exhibit to the Registration Statement of which this
Prospectus is  a part.  The following  summaries of  certain provisions  of  the
Indenture do not purport to be complete and are subject to, and are qualified in
their  entirety by reference  to, all the provisions  of the Indenture. Wherever
particular provisions of the Indenture or terms defined therein are referred  to
herein   or  in  the  Prospectus  Supplement,   such  provisions  or  terms  are
incorporated by reference as a part  of the statements made, and the  statements
are  qualified  in  their entirety  by  such reference.  Section  references are
references to sections of the Indenture. Capitalized terms not otherwise defined
herein have the meanings given to them in the Indenture.
 
GENERAL
 
     The Debt  Securities  will  rank  equally  with  all  other  unsecured  and
unsubordinated  debt of the Company. The Indenture  does not limit the amount of
debt which may be issued  by the Company under  the Indenture or otherwise.  The
Debt  Securities may be  issued in one or  more series with  the same or various
maturities, at par or a premium or with original issue discount.
 
     Reference is made to the Prospectus  Supplement for the following terms  of
the  Debt  Securities offered  pursuant to  this  Prospectus and  the Prospectus
Supplement: (i) the designation  of and any limit  upon the aggregate  principal
amount  of such  Debt Securities; (ii)  the price  or prices at  which such Debt
Securities will be offered  (expressed as a percentage  of the principal  amount
thereof);  (iii) the date  or dates on  which such Debt  Securities will mature;
(iv) the currency or currencies of  denomination of such Debt Securities,  which
may  be U.S.  dollars or any  foreign currency or  units based on  or related to
currencies; (v) the designation of the currency or currencies, or units based on
or related to currencies, in which payment  of the principal of and any  premium
and any interest on such Debt Securities will be made, and whether, in the event
such  Debt Securities  are not  denominated in U.S.  dollars but  the payment of
principal thereof  and any  premium  and interest  thereon  is payable  in  U.S.
dollars,  payment of the  principal of and  any premium or  any interest on such
Debt Securities, at the election of a holder thereof, may instead be payable  in
the  currency, or units  based on or  related to currencies,  in which such Debt
Securities are  denominated; (vi)  the rate  or  rates (which  may be  fixed  or
floating) per annum, if any, at which such Debt Securities will bear interest or
the method of determining such rate or rates; (vii) the date or dates from which
any  such interest shall  accrue, the Interest  Payment Dates on  which any such
interest shall be payable and the  Regular Record Date for any interest  payable
on any Interest Payment Date; (viii) any index or other method used to determine
the amounts of payments of principal of and any premium on such Debt Securities;
(ix)   any  optional  or  mandatory  redemption  or  repayment  terms;  (x)  the
denominations in which  such Debt  Securities shall  be issuable  if other  than
denominations  of $1,000  and any integral  multiple thereof;  (xi) whether such
Debt Securities are to be  issued in the form of  Global Securities and, if  so,
the  identity of the Depository with respect to such Global Securities; (xii) in
the case of Debt Securities issued  with original issue discount, the  principal
amount thereof payable upon acceleration of the maturity thereof; and (xiii) any
other specific terms associated with such Debt Securities.
 
                                       4
 

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<PAGE>
     Unless  otherwise set forth in the  Prospectus Supplement, the principal of
and any premium and any interest on the Debt Securities is payable to registered
holders of Debt Securities at the principal  office of the Trustee in New  York,
New York, or at any paying agency maintained at the time by the Company for such
purpose. At the option of the Company, payment of interest to registered holders
of  Debt Securities  may be made  by check mailed  to the address  of the person
entitled thereto as it appears on the register for Debt Securities.
 
     The Debt Securities  shall be issued  in fully registered  form unless  the
Prospectus   Supplement  provides  otherwise.  (Section   301)  Subject  to  the
limitations provided  in the  Indenture, Debt  Securities may  be presented  for
registration  of transfer or exchange  at such office of  the Trustee or at such
other location or  locations as  may be  established pursuant  to the  Indenture
without  any service charge, although  the Company may require  payment of a sum
sufficient to cover any tax or  other governmental charge payable in  connection
therewith. (Section 305)
 
GLOBAL SECURITIES
 
     The Debt Securities may be issued in whole or in part in the form of one or
more  Global  Securities that  will  be deposited  with,  or on  behalf  of, the
Depository identified in  the Prospectus  Supplement. Global  Securities may  be
issued  only in fully registered form and in either temporary or permanent form.
Unless and until it  is exchanged in  whole or in part  for the individual  Debt
Securities  represented thereby, a Global Security may not be transferred except
as a whole  by the  Depository for  such Global Security  to a  nominee of  such
Depository  or by  a nominee  of such Depository  to such  Depository or another
nominee of  such  Depository  or  by  the Depository  or  any  nominee  of  such
Depository to a successor Depository or any nominee of such successor.
 
     The  specific  terms of  any depository  arrangement  with respect  to Debt
Securities issued in the form of one or more Global Securities will be described
in the  Prospectus  Supplement. Unless  otherwise  specified in  the  Prospectus
Supplement, the following provisions will apply to all depository arrangements.
 
     Upon  the issuance  of a  Global Security,  the Depository  for such Global
Security or its nominee will credit on its book-entry registration and  transfer
system  the  respective  principal  amounts of  the  individual  Debt Securities
represented by such Global  Security to the accounts  of institutions that  have
accounts   with  such  Depository  ('Participants').   Such  accounts  shall  be
designated by the  underwriters, dealers  or agents  with respect  to such  Debt
Securities  or  by the  Company if  such  Debt Securities  are offered  and sold
directly by the  Company. Owners of  beneficial interests in  a Global  Security
that  are not  Participants or  persons that  may hold  through Participants but
desire to sell or otherwise transfer  ownership of such beneficial interests  by
book-entry  on the records of the Depository may do so only through Participants
and persons that may hold through Participants. Because the Depository can  only
act  on behalf of  Participants and persons that  may hold through Participants,
the ability of an owner of a beneficial interest in a Global Security to  pledge
such  beneficial interests to persons or entities that do not participate in the
book-entry and transfer system of the  Depository, or otherwise take actions  in
respect  of such beneficial interests,  may be limited. The  laws of some states
require that certain  purchasers of  securities take physical  delivery of  such
securities  in definitive form. Such limitations  on the ownership of beneficial
interests in a Global Security and such laws may impair the ability to  transfer
beneficial interests in a Global Security.
 
     So  long as  the Depository  for a  Global Security  or its  nominee is the
registered owner of such  Global Security, such Depository  or such nominee,  as
the  case  may be,  will be  considered the  sole  owner or  holder of  the Debt
Securities represented  by  such Global  Security  for all  purposes  under  the
Indenture.  Except as provided below, owners of beneficial interests in a Global
Security will not be entitled to have  any of the individual Debt Securities  of
the  series represented by such Global  Security registered in their names, will
not receive  or  be entitled  to  receive physical  delivery  of any  such  Debt
Securities  of such  series in  definitive form and  will not  be considered the
owners or holders thereof under the Indenture.
 
     Payments of principal  of (and premium,  if any) and  interest, if any,  on
Debt  Securities represented by  a Global Security  registered in the  name of a
Depository or its nominee will be made to the
 
                                       5
 

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<PAGE>
Depository or its nominee, as  the case may be, as  the registered owner of  the
Global  Security representing  such Debt  Securities. None  of the  Company, the
Trustee, any paying agent  or registrar for such  Debt Securities will have  any
responsibility  or  liability for  any  aspect of  the  records relating  to, or
payments made  on  account of,  beneficial  ownership interests  in  the  Global
Security  for such Debt Securities or  for maintaining, supervising or reviewing
any records relating to such beneficial ownership interests.
 
     The Company expects that the Depository for a series of Debt Securities  or
its  nominee, upon receipt of  any payment of principal,  premium or interest in
respect  of  a  Global  Security  representing  any  of  such  Debt  Securities,
immediately   will  credit  Participants'  accounts  with  payments  in  amounts
proportionate to their respective beneficial  interests in the principal  amount
of  such  Global Security  as shown  on the  records of  such Depository  or its
nominee. The Company  also expects that  payments by Participants  to owners  of
beneficial interests in such Global Security held through such Participants will
be governed by standing instructions and customary practices, as is now the case
with  securities held for the accounts of customers in bearer form or registered
in 'street name'. Such payments will be the responsibility of such  Participants
and  not of  the Company  or the Depository.  Owners of  beneficial interests in
Global Securities  may experience  some delay  in the  receipt of  interest  and
principal  payments since the Depository for such Global Securities will forward
payments to its Participants,  which in turn will  forward them to persons  that
hold beneficial interests in such Global Securities through such Participants.
 
     If  a Depository for a series of  Debt Securities is at any time unwilling,
unable or ineligible to continue as depository and a successor depository is not
appointed by the Company within 90 days, the Company will issue individual  Debt
Securities of such series in definitive form in exchange for the Global Security
representing such series of Debt Securities. In addition, the Company may at any
time  and in its  sole discretion, subject  to any limitations  described in the
Prospectus Supplement, determine not to have any Debt Securities of such  series
represented  by one  or more  Global Securities and,  in such  event, will issue
individual Debt Securities of such series in exchange for the Global Security or
Securities representing such series of Debt Securities. In either instance,  the
Company  will  issue  Debt Securities  in  definitive form,  equal  in aggregate
principal amount to the Global Securities,  in such names and in such  principal
amounts  as the Depository for such  Global Securities shall request. Individual
Debt Securities of such series so issued will be issued in denominations, unless
otherwise specified by the Company, of $1,000 and integral multiples thereof.
 
COVENANTS
 
     The covenants  summarized  below  will  be  applicable  (unless  waived  or
amended)  so long as any  of the Debt Securities  are outstanding, unless stated
otherwise in the Prospectus Supplement.
 
LIMITATION ON LIENS
 
     Unless otherwise provided  in the  Prospectus Supplement,  the Company  has
covenanted  not to create, assume or suffer  to exist any Lien on any Restricted
Property to secure any Debt of the Company, any Subsidiary or any other  person,
or  permit any Subsidiary so to do,  without securing the Debt Securities of any
series having the benefit of this covenant by such Lien equally and ratably with
(or prior to) such Debt for so long as such Debt shall be so secured, subject to
certain exceptions  specified in  the Indenture.  Exceptions include:  (a)  with
respect to any series of Debt Securities, Liens existing on the date of issuance
of  such series; (b)  Liens on Restricted  Property of corporations  at the time
they become  Subsidiaries;  (c)  Liens  existing  on  Restricted  Property  when
acquired  by the Company or any Subsidiary; (d) Liens to secure Debt incurred to
finance the purchase price, construction,  alteration, repair or improvement  of
Restricted  Property;  (e) Liens  securing  Debt of  a  Subsidiary owing  to the
Company or  another  Subsidiary;  (f)  Liens  securing  industrial  development,
pollution  control, or similar revenue bonds; and (g) Liens otherwise prohibited
by such covenant, securing Debt  which, together with the aggregate  outstanding
principal  amount of all other  Debt of the Company  and its Subsidiaries owning
Restricted Property which would  otherwise be subject to  such covenant and  the
Value  of certain existing Sale and  Leaseback Transactions, does not exceed 10%
of Consolidated Net Tangible Assets. (Section 1006)
 
                                       6
 

<PAGE>
<PAGE>
LIMITATION ON SALE AND LEASEBACK TRANSACTIONS
 
     Unless otherwise provided  in the  Prospectus Supplement,  the Company  has
also  covenanted  not to,  and not  to permit  any Subsidiary  owning Restricted
Property to,  enter  into  any  Sale  and  Leaseback  Transaction  covering  any
Restricted  Property  unless  (a)  the  Company  would  be  entitled  under  the
provisions described  under 'Limitation  on  Liens' above  to  incur Debt  in  a
principal  amount equal  to the  Value of  such Sale  and Leaseback Transaction,
secured by Liens  on the facilities  to be leased,  without equally and  ratably
securing  the  Debt  Securities,  or  (b) the  Company,  during  the  six months
following the effective date of such Sale and Leaseback Transaction, applies  an
amount  equal  to  the Value  of  such  Sale and  Leaseback  Transaction  to the
acquisition of  Restricted  Property or  to  the voluntary  retirement  of  Debt
Securities  or  Funded Debt,  whether by  redemption, defeasance,  repurchase or
otherwise, and after crediting to the amount applied pursuant to this  provision
the  principal amount  of any  Debt Securities or  Funded Debt  delivered to the
Trustee for  retirement  and  cancellation during  the  six  months  immediately
following  the effective date  of such Sale  and Leaseback Transaction. (Section
1007)
 
GENERAL
 
     Because the covenants described  above cover only manufacturing  facilities
in the continental United States, the Company's facilities in Puerto Rico, Latin
America,  Canada, Asia and  Europe (accounting for approximately  34% of the net
book value  of  the  Company's  facilities  worldwide)  are  excluded  from  the
operation of these covenants.
 
     None  of the  properties of  the Company  that would  qualify as Restricted
Property is subject to any Liens prohibited by the covenants described above  or
to any Sale and Leaseback Transactions prohibited by such covenants. The Company
does not keep records identifying which of its properties, if any, would qualify
as  Restricted Property. The  Company will amend this  Prospectus to disclose or
disclose in the Prospectus Supplement the existence  of any Lien on or any  Sale
and  Leaseback Transaction covering any  Restricted Property which would require
the Company to secure the Debt Securities or apply certain amounts to retirement
of indebtedness or acquisitions of property, as provided in such covenants.
 
     Other than the restrictions  on Liens and  Sale and Leaseback  Transactions
described  above,  the Indenture  and  the Debt  Securities  do not  contain any
covenants or other provisions designed to afford holders of the Debt  Securities
protection in the event of a highly leveraged transaction involving the Company.
 
CERTAIN DEFINITIONS
 
     Certain terms defined in Section 101 of the Indenture are summarized below.
 
     'Consolidated  Net Tangible Assets' means, with respect to the Company, the
total amount  of  its  assets  (less  applicable  reserves  and  other  properly
deductible  items) after  deducting (a)  all current  liabilities (excluding the
amount of liabilities which  are by their terms  extendable or renewable at  the
option  of the obligor to a date more than  12 months after the date as of which
the amount is being  determined) and (b)  all goodwill, tradenames,  trademarks,
patents, unamortized debt discount and expense and other like intangible assets,
all  as  set forth  on the  most recent  balance  sheet of  the Company  and its
consolidated subsidiaries and determined on  a consolidated basis in  accordance
with generally accepted accounting principles.
 
     'Debt' means (i) all obligations represented by notes, bonds, debentures or
similar  evidences of indebtedness; (ii) all  indebtedness for borrowed money or
for the deferred purchase price of property or services other than, in the  case
of any such deferred purchase price, on normal trade terms; and (iii) all rental
obligations  as  lessee under  leases which  shall  have been  or should  be, in
accordance with generally  accepted accounting principles,  recorded as  capital
leases.
 
     'Funded  Debt' means Debt of the  Company or a Subsidiary owning Restricted
Property maturing by its terms  more than one year  after its creation and  Debt
classified as long-term debt under generally
 
                                       7
 

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<PAGE>
accepted  accounting principles and, in the case  of Funded Debt of the Company,
ranking at least pari passu with the Debt Securities.
 
     'Lien' means any  mortgage, pledge, lien,  encumbrance, charge or  security
interest.
 
     'Restricted  Property'  means (a)  any  manufacturing facility,  or portion
thereof, owned or leased by the Company or any Subsidiary and located within the
continental United  States of  America which,  in the  opinion of  the Board  of
Directors,  is of  material importance  to the business  of the  Company and its
Subsidiaries taken as a  whole, but no such  manufacturing facility, or  portion
thereof,  shall be deemed of material importance if its gross book value (before
deducting accumulated depreciation) is less than 2% of Consolidated Net Tangible
Assets, and (b) any  shares of capital stock  or indebtedness of any  Subsidiary
owning   any  such   manufacturing  facility.   As  used   in  this  definition,
'manufacturing facility' means  property, plant  and equipment  used for  actual
manufacturing  and  for activities  directly  related to  manufacturing,  and it
excludes sales  offices,  research  facilities  and  facilities  used  only  for
warehousing, distribution or general administration.
 
     'Sale  and  Leaseback Transaction'  means any  arrangement with  any person
pursuant to which the Company or  any Subsidiary leases any Restricted  Property
that  has been or is to be sold  or transferred by the Company or the Subsidiary
to such person, other than (a)  temporary leases for a term, including  renewals
at  the option of the  lessee, of not more than  three years, (b) leases between
the Company and a Subsidiary or  between Subsidiaries, (c) leases of  Restricted
Property  executed by the time of, or within  12 months after the latest of, the
acquisition, the completion of construction or improvement, or the  commencement
of  commercial  operation, of  such  Restricted Property,  and  (d) arrangements
pursuant to any provision  of law with  an effect similar  to that under  former
Section 168(f)(8) of the Internal Revenue Code of 1954.
 
     'Subsidiary'  means a  corporation the  majority of  the outstanding voting
stock of which is owned, directly or  indirectly, by the Company or one or  more
Subsidiaries.
 
     'Value'  means, with respect to a Sale and Leaseback Transaction, an amount
equal to the present value of the lease payments with respect to the term of the
lease remaining on the date as of which the amount is being determined,  without
regard to any renewal or extension options contained in the lease, discounted at
the  weighted  average  interest  rate  on the  Debt  Securities  of  all series
(including the  effective interest  rate  on any  Original Issue  Discount  Debt
Securities)  which  are  outstanding on  the  effective  date of  such  Sale and
Leaseback Transaction and which have the  benefit of the covenant limiting  Sale
and Leaseback Transactions.
 
EVENTS OF DEFAULT; WAIVER AND NOTICE THEREOF; DEBT SECURITIES IN FOREIGN
CURRENCIES
 
     As  to any series of Debt Securities, an Event of Default is defined in the
Indenture as being any one of the following events and such other events as  may
be  established for the Debt Securities of  such series: (a) default for 30 days
in payment of any interest on the Debt Securities of such series; (b) default in
payment of principal of  or any premium  on the Debt  Securities of such  series
when  due; (c) default in  payment of any sinking  or purchase fund or analogous
obligation, if any, on the  Debt Securities of such  series; (d) default by  the
Company  in the performance of  any other covenant or  warranty contained in the
Indenture for the benefit of such series which shall not have been remedied  for
a period of 90 days after notice is given as specified in the Indenture; and (e)
certain  events of bankruptcy, insolvency and reorganization of the Company. Any
additional Events of Default and any changes to the foregoing Events of  Default
applicable  to a particular series  of Debt Securities will  be described in the
prospectus supplement relating to such series. (Sections 301 and 501)
 
     A default under  other indebtedness of  the Company will  not be a  default
under  the Indenture, and a default under one series of Debt Securities will not
necessarily be a default under another series.
 
     The Indenture provides that (i) if an Event of Default described in  clause
(a),  (b), (c) or  (d) above (if the  Event of Default under  clause (d) is with
respect to less than all series of Debt Securities then outstanding) shall  have
occurred and be continuing with respect to any series, either the Trustee or the
holders  of  not  less  than  25% in  aggregate  principal  amount  of  the Debt
Securities of  such  series then  outstanding  (each  such series  acting  as  a
separate  class) may declare  the principal (or,  in the case  of Original Issue
Discount Securities, the portion thereof specified in the terms thereof) of  all
outstanding
 
                                       8
 

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<PAGE>
Debt  Securities of such series and the  interest accrued thereon, if any, to be
due and payable immediately; and (ii) if an Event of Default described in clause
(d) or (e) above (if  the Event of Default under  clause (d) is with respect  to
all  series  of Debt  Securities then  outstanding) shall  have occurred  and be
continuing, either  the Trustee  or the  holders of  at least  25% in  aggregate
principal  amount of all Debt Securities then outstanding (treated as one class)
may  declare  the  principal  (or,  in  the  case  of  Original  Issue  Discount
Securities,  the portion  thereof specified  in the  terms thereof)  of all Debt
Securities then outstanding and the interest accrued thereon, if any, to be  due
and  payable immediately, but  upon certain conditions  such declarations may be
annulled and past defaults (except for defaults in the payment of principal  of,
any  premium on, or any interest on, such Debt Securities and in compliance with
certain covenants)  may be  waived by  the holders  of a  majority in  aggregate
principal  amount  of  the  Debt Securities  of  such  series  then outstanding.
(Sections 502 and 513)
 
     Under the Indenture, the Trustee must give to the holders of each series of
Debt Securities notice of all uncured defaults known to it with respect to  such
series  within 90 days  after such a  default occurs, unless  such default shall
have been cured or waived; provided that  in the case of a default described  in
clause  (d) above, no  such notice shall be  given until at  least 90 days after
such default occurs; and provided further that, except in the case of default in
the payment of principal of and any premium  or any interest on any of the  Debt
Securities,  or  default  in  the  payment  of  any  sinking  or  purchase  fund
installment  or  analogous  obligations,  the  Trustee  shall  be  protected  in
withholding  such notice if it in good  faith determines that the withholding of
such notice is in the  interests of the holders of  the Debt Securities of  such
series.  For the purpose of this paragraph, the term default includes the events
specified above without notice or grace periods. (Section 602)
 
     No holder of  any Debt Securities  of any series  may institute any  action
under  the Indenture unless (a) such holder shall have given the Trustee written
notice of a continuing  Event of Default  with respect to  such series; (b)  the
holders  of  not  less  than  25% in  aggregate  principal  amount  of  the Debt
Securities of such series then outstanding  shall have requested the Trustee  to
institute  proceedings in respect of  such Event of Default;  (c) such holder or
holders shall have offered the Trustee such reasonable indemnity as the  Trustee
may  require; (d) the  Trustee shall have  failed to institute  an action for 60
days thereafter; and (e) no inconsistent direction shall have been given to  the
Trustee  during such  60-day period  by the holders  of a  majority in aggregate
principal amount of Debt Securities of such series. (Section 507)
 
     The holders  of  a majority  in  aggregate  principal amount  of  the  Debt
Securities  of any  series affected  and then  outstanding will  have the right,
subject to  certain  limitations,  to  direct the  time,  method  and  place  of
conducting  any proceeding for any remedy available to the Trustee or exercising
any trust or power conferred on the Trustee with respect to such series of  Debt
Securities.  (Section  512) The  Indenture provides  that, in  case an  Event of
Default shall occur and be continuing, the Trustee, in exercising its rights and
powers under the  Indenture, will be  required to use  the degree of  care of  a
prudent  person in the conduct of his  or her own affairs. The Indenture further
provides that the Trustee shall not be required to expend or risk its own  funds
or  otherwise incur  any financial  liability in the  performance of  any of its
duties under  the Indenture  if it  has reasonable  grounds for  believing  that
repayment  of such funds or adequate indemnity against such risk or liability is
not reasonably assured to it. (Section 601)
 
     The Company must furnish to  the Trustee within 120  days after the end  of
each  fiscal year a statement  signed by certain officers  of the Company to the
effect that a review of  the activities of the Company  during such year and  of
its  performance under the  Indenture and the  terms of the  Debt Securities has
been made, and, to the  best of the knowledge of  the signatories based on  such
review,  the Company is not in default  in the performance and observance of the
terms of  the  Indenture or,  if  the Company  is  in default,  specifying  such
default. (Section 1004)
 
     If  any Debt Securities are not  denominated in United States dollars, then
for the purposes of determining whether  the holders of the requisite  principal
amount  of Debt Securities have taken any  action as described in the Indenture,
the principal amount of such Debt Securities  shall be deemed to be that  amount
of United States dollars that could be obtained for such principal amount on the
basis  of the spot rate of exchange  into United States dollars for the currency
or units based on  or related to  currencies in which  such Debt Securities  are
denominated (as evidenced to the Trustee by an Officers'
 
                                       9
 

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<PAGE>
Certificate)  as of the  date the taking of  such action by  the holders of such
requisite principal  amount is  evidenced  to the  Trustee  as provided  in  the
Indenture. (Section 104)
 
     If any Debt Securities are Original Issue Discount Securities, then for the
purposes of determining whether the holders of the requisite principal amount of
Debt  Securities have taken any action herein described, the principal amount of
such Debt Securities shall be deemed to be the portion of such principal  amount
that  would be due and payable  at the time of the  taking of such action upon a
declaration of acceleration of the maturity thereof. (Section 101)
 
CONSOLIDATION, MERGER, SALE OR CONVEYANCE
 
     The Indenture provides that the Company  may not consolidate with or  merge
into  any  other corporation  or convey  or transfer  its properties  and assets
substantially as an entirety  to any person, unless  (a) the successor shall  be
organized  and existing under the laws of the United States or any State thereof
or the  District of  Columbia,  and shall  expressly  assume by  a  supplemental
indenture  the due and punctual  payment of the principal  of and any premium or
any interest on all the Debt Securities and the performance of every covenant in
the Indenture  on the  part of  the Company  to be  performed or  observed;  (b)
immediately after giving effect to such transaction, no Event of Default, and no
event  which, after notice  or lapse of time  or both, would  become an Event of
Default, shall have happened and be  continuing; and (c) the Company shall  have
delivered  to the  Trustee an Officers'  Certificate and an  Opinion of Counsel,
each stating that such  consolidation, merger, conveyance  or transfer and  such
supplemental  indenture comply  with the  foregoing provisions  relating to such
transaction. (Section 801) In case of any such consolidation, merger, conveyance
or transfer, such successor will succeed  to and be substituted for the  Company
as  obligor on the Debt Securities, with the same effect as if it had been named
in the Indenture as the Company. (Section 802)
 
MODIFICATION OF THE INDENTURE
 
     With certain exceptions, the Indenture or the rights of the holders of  the
Debt  Securities may be modified by the Company and the Trustee with the consent
of the  holders  of  a  majority  in aggregate  principal  amount  of  the  Debt
Securities of each series affected by such modification then outstanding, but no
such  modification  may  be made  without  the  consent of  the  holder  of each
outstanding Debt Security affected thereby  which would (a) change the  maturity
of  any payment of principal of or any premium or any installment of interest on
any Debt Security, or reduce the principal amount thereof or the interest or any
premium thereon,  or change  the method  of computing  the amount  of  principal
thereof or interest thereon on any date or change any place of payment where, or
the  currency (or units  based on or  related to currencies)  in which, any Debt
Security or any premium or interest  thereon is payable, or change the  currency
(or  units based  on or  related to  currencies) in  which any  Debt Security is
denominated, or impair the  right to institute suit  for the enforcement of  any
such  payment on or after the maturity thereof (or, in the case of redemption or
repayment, on or after the  redemption date or the  repayment date, as the  case
may  be); (b) reduce the percentage in  principal amount of the outstanding Debt
Securities of any series, the consent of whose holders is required for any  such
modification,  or the  consent of  whose holders is  required for  any waiver of
compliance  with  certain  provisions  of  the  Indenture  or  certain  defaults
thereunder  and their consequences provided for  in the Indenture; or (c) modify
any of  the provisions  of  certain Sections  of  the Indenture,  including  the
provisions  summarized in this paragraph, except to increase any such percentage
or to provide that certain other provisions of the Indenture cannot be  modified
or  waived without the consent  of the holder of  each outstanding Debt Security
affected thereby. (Section 902)
 
DEFEASANCE OF DEBT SECURITIES AND CERTAIN COVENANTS AND CERTAIN EVENTS OF
DEFAULT
 
     Unless otherwise indicated  in the Prospectus  Supplement, the Company,  at
its  option, either  (a) will  be discharged from  any and  all obligations with
respect to the Debt Securities (except  for certain obligations to register  the
transfer  or exchange of Debt Securities, replace stolen, lost or mutilated Debt
Securities, maintain paying agencies  and hold moneys for  payment in trust)  or
(b)  will cease to  be under any  obligation to comply  with certain restrictive
covenants of the Indenture (as described under
 
                                       10
 

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'Covenants' and  'Consolidation,  Merger,  Sale or  Conveyance'  and  any  other
limitations  applicable to the  Debt Securities that  are determined pursuant to
the Indenture to be subject to  the provision described in this paragraph),  and
certain  Events of  Default shall  cease to be  applicable, with  respect to any
series of Debt Securities, upon the deposit with the Trustee, in trust, of money
or the  equivalent in  non-callable securities,  or securities  callable at  the
option  of the holder, of the government  which issued the currency in which the
Debt Securities are denominated or government agencies backed by the full  faith
and  credit  of such  government, or  a combination  thereof, which  through the
payment of  interest thereon  and  principal thereof  in accordance  with  their
terms,  without reinvestment thereof, will provide money in an amount sufficient
to pay all  the principal (including  any mandatory sinking  fund payments)  and
premium  of, interest  on and  any repurchase  obligations with  respect to such
series of Debt Securities on the dates such payments are due in accordance  with
the  terms  of the  Debt Securities.  To exercise  any such  option no  Event of
Default or event which  with notice or  lapse of time would  become an Event  of
Default  with respect to such series of  Debt Securities shall have occurred and
be continuing. The Company is required to  deliver to the Trustee an Opinion  of
Counsel  to the effect that  the deposit and related  defeasance would not cause
the holders of the Debt Securities to recognize income, gain or loss for Federal
income tax purposes  and, in the  case of  a discharge pursuant  to clause  (a),
accompanied  by a ruling to such effect received from or published by the United
States Internal Revenue Service. (Section 403)
 
CONCERNING THE TRUSTEE
 
     The Trustee under  the Indenture from  time to time  has extended, and  may
continue  to extend, credit to the Company  and its subsidiaries in the ordinary
course of business. The  Company currently has a  line of credit available  from
the Trustee.
 
                              PLAN OF DISTRIBUTION
 
     The  Company may sell the Debt Securities being offered hereby: (i) through
underwriters or dealers;  (ii) through  agents; (iii)  directly to  one or  more
purchasers;  or (iv)  through a  combination of  any such  methods of  sale. The
Prospectus Supplement  sets  forth  the  terms of  the  offering  of  such  Debt
Securities,  including the name or names of any underwriters, dealers or agents,
the purchase price or  prices of such  Debt Securities and  the proceeds to  the
Company  from such sale, any underwriting discounts and other items constituting
compensation to underwriters,  dealers or  agents, any  initial public  offering
price  or prices, any discounts  or concessions allowed or  reallowed or paid by
underwriters or dealers to other dealers  and any securities exchanges on  which
such Debt Securities may be listed.
 
     If  underwriters or dealers are used in  the sale, the Debt Securities will
be acquired by  the underwriters or  dealers for  their own account  and may  be
resold  from  time to  time in  one or  more transactions,  including negotiated
transactions, at a  fixed public  offering price, which  may be  changed, or  at
varying  prices  determined at  the time  of  sale. The  Debt Securities  may be
offered to the public  either by underwriting syndicates  represented by one  or
more managing underwriters or by one or more of such firms. Unless otherwise set
forth  in  the Prospectus  Supplement, the  obligations  of the  underwriters to
purchase such Debt Securities will  be subject to certain conditions  precedent,
and  the underwriters will be obligated to  purchase all of such Debt Securities
if any are  purchased. Any initial  public offering price  and any discounts  or
concessions  allowed or reallowed or paid to dealers may be changed from time to
time.
 
     Debt Securities  may be  sold directly  by the  Company or  through  agents
designated  by the Company from time to time. Any agent involved in the offer or
sale of Debt Securities in respect of which this Prospectus is delivered will be
named, and any commissions payable by the  Company to such agent (or the  method
by  which such commissions can  be determined) are set  forth, in the Prospectus
Supplement. Unless otherwise  indicated in the  Prospectus Supplement, any  such
agent will be acting on a best efforts basis for the period of its appointment.
 
     If  so indicated in  the Prospectus Supplement,  the Company will authorize
underwriters,  dealers  or  agents  to  solicit  offers  by  certain   specified
institutions    to   purchase    Debt   Securities    from   the    Company   at
 
                                       11
 

<PAGE>
<PAGE>
the public offering  price set forth  in the Prospectus  Supplement pursuant  to
delayed  delivery contracts  providing for payment  and delivery  on a specified
date in the future. Such contracts will be subject only to those conditions  set
forth in the Prospectus Supplement, and the Prospectus Supplement sets forth the
commission  payable  for solicitation  of such  contracts. The  underwriters and
other persons  soliciting such  contracts will  have no  responsibility for  the
validity or performance of any such contracts.
 
     Underwriters,  dealers and agents may  be entitled under agreements entered
into with the Company  to indemnification by the  Company against certain  civil
liabilities,  including liabilities under the Securities Act, or to contribution
by the Company  to payments they  may be  required to make  in respect  thereof.
Underwriters,  dealers and  agents may be  customers of,  engage in transactions
with, or perform services for the Company in the ordinary course of business.
 
                                    EXPERTS
 
     The consolidated financial  statements incorporated in  this Prospectus  by
reference  to the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1992, have  been so incorporated in  reliance upon the reports  set
forth  therein  of  Price  Waterhouse,  independent  accountants,  given  on the
authority of said firm as experts in accounting and auditing.
 
                        VALIDITY OF THE DEBT SECURITIES
 
     The legality of the Debt Securities offered hereby will be passed upon  for
the  Company by Cravath, Swaine & Moore, Worldwide Plaza, 825 Eighth Avenue, New
York, New York, counsel to the Company,  and for the underwriters or agents,  if
any,  named in the Prospectus Supplement by Winthrop, Stimson, Putnam & Roberts,
One Battery Park Plaza, New York, New York. Winthrop, Stimson, Putnam &  Roberts
has  in the past represented and continues to represent the Company in a variety
of matters.
 
                                       12
 

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__________________________________            __________________________________
 
     NO  PERSON  HAS BEEN  AUTHORIZED TO  GIVE  ANY INFORMATION  OR TO  MAKE ANY
REPRESENTATIONS OTHER THAN THOSE CONTAINED IN THIS PROSPECTUS SUPPLEMENT OR  THE
PROSPECTUS,  AND, IF GIVEN OR MADE, SUCH INFORMATION OR REPRESENTATIONS MUST NOT
BE RELIED UPON  AS HAVING BEEN  AUTHORIZED. THIS PROSPECTUS  SUPPLEMENT AND  THE
PROSPECTUS DO NOT CONSTITUTE AN OFFER TO SELL OR THE SOLICITATION OF AN OFFER TO
BUY  ANY  SECURITIES  OTHER THAN  THE  SECURITIES DESCRIBED  IN  THIS PROSPECTUS
SUPPLEMENT OR AN  OFFER TO  SELL OR  THE SOLICITATION OF  AN OFFER  TO BUY  SUCH
SECURITIES IN ANY CIRCUMSTANCES IN WHICH SUCH OFFER OR SOLICITATION IS UNLAWFUL.
NEITHER  THE DELIVERY  OF THIS PROSPECTUS  SUPPLEMENT OR THE  PROSPECTUS NOR ANY
SALE MADE HEREUNDER  OR THEREUNDER  SHALL, UNDER ANY  CIRCUMSTANCES, CREATE  ANY
IMPLICATION  THAT THERE HAS BEEN  NO CHANGE IN THE  AFFAIRS OF THE COMPANY SINCE
THE DATE HEREOF OR THAT THE  INFORMATION CONTAINED HEREIN OR THEREIN IS  CORRECT
AS OF ANY TIME SUBSEQUENT TO ITS DATE.
 
                            ------------------------
                               TABLE OF CONTENTS
                             PROSPECTUS SUPPLEMENT
 
<TABLE>
<CAPTION>
                                                                                                                              PAGE
                                                                                                                              ----
 
<S>                                                                                                                           <C>
Description of Debentures..................................................................................................   S-2
 
Underwriting...............................................................................................................   S-3
 
Ratio of Earnings to Fixed Charges.........................................................................................   S-4
 
                                                            PROSPECTUS
 
Available Information......................................................................................................     2
 
Documents Incorporated by Reference........................................................................................     2
 
Bristol-Myers Squibb Company...............................................................................................     3
 
Ratio of Earnings to Fixed Charges.........................................................................................     3
 
Use of Proceeds............................................................................................................     4
 
Description of Debt Securities.............................................................................................     4
 
Plan of Distribution.......................................................................................................    11
 
Experts....................................................................................................................    12
 
Validity of the Debt Securities............................................................................................    12
</TABLE>
 
                                  $350,000,000
                                 BRISTOL-MYERS
                                 SQUIBB COMPANY
                              6.80% DEBENTURES DUE
                               NOVEMBER 15, 2026
 
                            ------------------------
                             PROSPECTUS SUPPLEMENT
                            ------------------------
                              GOLDMAN, SACHS & CO.
                         ABN AMRO SECURITIES (USA) INC.
                             CHASE SECURITIES INC.
                            PAINEWEBBER INCORPORATED
                       PRUDENTIAL SECURITIES INCORPORATED
 
__________________________________            __________________________________

<PAGE>



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