BRISTOL MYERS SQUIBB CO
S-8 POS, 1996-05-02
PHARMACEUTICAL PREPARATIONS
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                              Registration No. 33-
        -----------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549
                                ----------------

                                  Form S-8 POS

                                 Amendment No. 1
                                 Post-Effective
                           REGISTRATION STATEMENT 
                                      Under
                           THE SECURITIES ACT OF 1933
                                ----------------

                          BRISTOL-MYERS SQUIBB COMPANY

               (Exact name of issuer as specified in its charter)

Delaware                                                  22-0790350
(State of Incorporation)                    (I.R.S. Employer Identification No.)

                                 345 Park Avenue
                            New York, New York 10154
                                 (212) 546-4000
          (Address and telephone number of principal executive offices)


           BRISTOL-MYERS SQUIBB COMPANY SAVINGS AND INVESTMENT PROGRAM
           BRISTOL-MYERS SQUIBB COMPANY EMPLOYEE INCENTIVE THRIFT PLAN
      BRISTOL-MYERS SQUIBB PUERTO RICO, INC. SAVINGS AND INVESTMENT PROGRAM

                              (Full Title of Plans)

                                 ---------------

John L. McGoldrick, Esq.                            Alice C. Brennan, Esq.
Senior Vice President and General Counsel           Vice President and Secretary

                          Bristol-Myers Squibb Company
                                 345 Park Avenue
                            New York, New York 10154
                                 (212) 546-4000
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                                    Copy to:

                       Winthrop, Stimson, Putnam & Roberts
                             One Battery Park Plaza
                          New York, New York 10004-1490
                                 (212) 858-1125
                        Attention: Susan P. Serota, Esq.


                         CALCULATION OF REGISTRATION FEE
================================================================================


Title of                     Proposed Maximum  Proposed Maximum     Amount of
Securities to  Amount to be  Offering Price    Aggregate Offering   Registration
be Registered  Registered    Per Share         Price                Fee    
<PAGE>
- --------------------------------------------------------------------------------
Common Stock,
par value $.10
per share .... [fee         (fee               (fee                 (fee
                previously   previously        previously           previously
                paid]        paid)             paid)                paid)

================================================================================

                  The  purpose of this filing is to  electronically  file on the
Commission's  Electronic Data Gathering,  Analysis and Retrieval  (EDGAR) System
pursuant  to Rule 103 of  Regulation  S-T a  complete  copy of the  Registration
Statement on Form S-8 (the "Registration  Statement") (File No. 333-02873) filed
in connection  with the issuance of additional  shares of  Bristol-Myers  Squibb
Company  Common  Stock  under  the  Bristol-Myers  Squibb  Company  Savings  and
Investment Program,  Bristol-Myers Squibb Company Employee Incentive Thrift Plan
and the  Bristol-Myers  Squibb Puerto Rico, Inc. Savings and Investment  Program
(the "Plans").

                  Certain exhibits which were part of the original  Registration
Statement  had been  inadvertently  "dropped"  from the  filing  at the time the
Registration Statement was submitted to the EDGAR System. However, both exhibits
had been executed and were  available on a timely basis on April 22, 1996.  This
amended  filing is  identical in all respects  with that  original  Registration
Statement on Form S-8 with the exception that the amended filing  contains those
two exhibits.

Item 8.  Exhibits.

Exhibit No.                Description
- -----------                -----------

5.1                        Opinion  from  Counsel  for  the  Company  as to  the
                           legality of the Company's  Common Stock offered under
                           the Plans.

5.2                        Opinion  from  Counsel for the Company that the Plans
                           are qualified  under  Section  401(a) of the Internal
                           Revenue   Code  of  1986,   as  amended  and  are  in
                           compliance  with  the  Employee   Retirement   Income
                           Security Act of 1974, as amended.

99                         Registration Statement on Form S-8


                                       -1-

<PAGE>

                                   SIGNATURES


                  Pursuant to the  requirements  of the  Securities Act of 1933,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized,  in  the  City of New  York,  State of New  York,  on the 25th
day of April, 1996.



                                    BRISTOL-MYERS SQUIBB COMPANY,


                                    By  /s/ Charles A. Heimbold, Jr.
                                       ---------------------------- 
                                      Charles A. Heimbold, Jr.
                                      President, Chief Executive
                                      Officer, Chairman of the
                                      Board and Director

                                POWER OF ATTORNEY


                  Know  all by men by  these  presents,  that  each  officer  or
director  of  Bristol-Myers  Squibb  Company,   whose  signature  appears  below
constitutes  and appoints  Alice C. Brennan,  John L.  McGoldrick,  Frederick S.
Schiff  and  Charles  G.  Tharp  and each of them  singly,  his true and  lawful
attorney-in-fact and agent, with full and several power of substitution, for him
and in  his  name,  place  and  stead,  in any  an  all  capacities,  to  sign a
Registration Statement on Form S-8 to be filed pursuant to the Securities Act of
1933 in connection  with the  registration  of up to 6,000,000  shares of Common
Stock, par value $.10 per share,  and any or all amendments,  including pre- and
post-effective amendments and supplements to this Registration Statement, and to
file the same,  with all exhibits  thereto,  and other  documents in  connection
therewith,  with the  Securities  and Exchange  Commission,  granting  unto said
attorney-in-fact  and agent full power and  authority to do and perform each and
every  act and  thing  requisite  and  necessary  to be done  in and  about  the
premises,  as  fully  to all  intents  and  purposes  as he might or could do in
person, hereby ratifying and confirming all that said attorney-in-fact and agent
or his substitute or  substitutes,  may lawfully do or cause to be done. Each of
said  attorneys-in-fact  shall have power to act  hereunder  with or without the
other.

                                       -2-

<PAGE>

                  Pursuant to the  requirements  of the  Securities Act of 1933,
this Form S-8 has been signed by the following  persons in the capacities and on
the date indicated:


Signature                           Title                                Date
- ---------                           -----                                ----

/s/ Charles A. Heimbold, Jr.        President, Chief                     4/25/96
- ---------------------------         Executive Officer,
Charles A. Heimbold, Jr.            Chairman of the
                                    Board and Director
                                    (principal executive
                                    officer)

/s/ Michael F. Mee                  Corporate Staff                      4/25/96
- ------------------                  Senior Vice President
Michael F. Mee                      and Chief Financial
                                    Officer (principal
                                    financial officer)


/s/ Frederick S. Schiff             Corporate Staff                      4/25/96
- -----------------------             Vice President
Frederick S. Schiff                 and Controller
                                    (principal
                                    accounting officer)

/s/ Robert E. Allen                 Director                             4/25/96
- -------------------
Robert E. Allen

/s/ Michael E. Autera               Executive Vice                       4/25/96
- ---------------------               President and
Michael E. Autera                   Director

/s/ Ellen V. Futter                 Director                             4/25/96
- -------------------
Ellen V. Futter


/s/ Louis V. Gerstner, Jr.          Director                             4/25/96
- -------------------------
Louis V. Gerstner, Jr.


/s/ John D. Macomber                Director                             4/25/96
- --------------------
John D. Macomber

                                       -3-

<PAGE>

Signature                           Title                                Date
- ---------                           -----                                ----


/s/ James D. Robinson III           Director                             4/25/96
- -------------------------
James D. Robinson III



/s/ Andrew C. Sigler                Director                             4/25/96
- --------------------     
Andrew C. Sigler



/s/ Louis W. Sullivan, M.D.         Director                             4/25/96
- --------------------------
Louis W. Sullivan, M.D.



/s/ Kenneth E. Weg                  Executive Vice                       4/25/96
- ------------------                  President and
Kenneth E. Weg                      Director



By /s/ Alice C. Brennan
   --------------------
   Alice C. Brennan
   Attorney-in-Fact

                                       -4-

<PAGE>

                  THE PLANS.  Pursuant to the requirements of the Securities Act
of 1933, the Plans have duly caused the  Registration  Statement to be signed on
their behalf by the undersigned,  thereunto duly authorized,  in the City of New
York, and the State of New York, on the 25th day of April, 1996.

BRISTOL-MYERS SQUIBB COMPANY SAVINGS
AND INVESTMENT PROGRAM
BRISTOL-MYERS SQUIBB COMPANY EMPLOYEE
INCENTIVE THRIFT PLAN
BRISTOL-MYERS SQUIBB PUERTO RICO, INC.
SAVING AND INVESTMENT PROGRAM

BY:  BRISTOL-MYERS SQUIBB COMPANY
     SAVINGS PLAN COMMITTEE


Signature                                   Title
- ---------                                   -----

/s/ Michael F. Mee                          Senior Vice President*
- ------------------
Michael F. Mee


/s/ Harrison M. Bains, Jr.                  Vice President and
- -------------------------                   Treasurer*
Harrison M. Bains, Jr.

/s/ Alice C. Brennan                        Vice President and
- --------------------                        Secretary*
Alice C. Brennan 

/s/ Robert B. Chapman, Jr.                  Director, Pension
- --------------------------                  & Savings Investment
Robert B. Chapman, Jr.                      Management*

/s/ John D. Glover                          Vice President*
- ------------------
John D. Glover


/s/ George P. Kooluris                      Senior Vice President*
- ----------------------
George P. Kooluris


/s/ John L. McGoldrick                      Senior Vice President*
- ----------------------
John L. McGoldrick

                                       -5-

<PAGE>

Signature                                   Title
- ---------                                   -----

/s/ Frederick S. Schiff                    Vice President and
- -----------------------                    Controller*
Frederick S. Schiff

/s/ Charles G. Tharp                       Senior Vice President*
- --------------------
Charles G. Tharp



- --------
*        Members of Bristol-Myers Squibb Company Savings Plan Committee, signing
         in that capacity on behalf of the Bristol-Myers  Squibb Company Savings
         and Investment  Program,  the  Bristol-Myers  Squibb  Company  Employee
         Incentive  Thrift Plan and the  Bristol-Myers  Squibb Puerto Rico, Inc.
         Savings and Investment Program.


                                       -6-

<PAGE>

                                                                     Exhibit 5.1








                                                  April 22, 1996





Bristol-Myers Squibb Company
345 Park Avenue
New York, New York 10154


Re:      Bristol-Myers Squibb Company - Registration of up to
         6,000,000 shares of Bristol-Myers Squibb Company Common
         Stock, par value $.10 per share, on Form S-8 relating to
         Bristol-Myers Squibb Company Savings and Investment Program,
         Bristol-Myers Squibb Company Employee Incentive Thrift Plan,
         and Bristol-Myers Squibb Puerto Rico, Inc. Savings and
         Investment Program (collectively, the "Plans")

Ladies and Gentlemen:

                  In  connection  with the proposed  issuance of up to 6,000,000
shares of  Bristol-Myers  Squibb  Company's  common  stock ($.10 par value) (the
"Shares")  for  purchase  pursuant to options  granted  under the Plans and with
respect  to  which  a  post-effective  amendment  to that  certain  Registration
Statement  (Reg.  No.  33-44788)  filed by  Bristol-Myers  Squibb  Company  (the
"Company") on Form S-8 (the "Amended Registration  Statement") has been prepared
for  filing  with  the  Securities  and  Exchange  Commission  pursuant  to  the
Securities  Act of 1933, as amended,  I have examined  such  corporate  records,
other documents and questions of law as I considered  necessary for the purposes
of this opinion.

                  I am of the opinion that when:

                  (a)  the applicable  provisions of the  Securities Act of 1933
         and of State securities or blue sky laws shall have been complied with;
         and

                  (b)  the  Company's   Board  of  Directors   shall  have  duly
         authorized the issuance of such Shares, and

                  (c)  the Shares shall have been duly issued and paid for in an
         amount not less than par value of $.10 per share,


<PAGE>


the Shares will be legally issued, fully paid and non-assessable.

                  I hereby  consent to the use of this  opinion as an Exhibit to
the Amended Registration  Statement on Form S-8 and to the reference to me under
the  caption  "Legal  Opinion" in the Amended  Registration  Statement,  and any
amendments thereto, filed in connection with the Plan.

                                    Very truly yours,


                                    /s/ John L. McGoldrick, Esq.
                                    ----------------------------
                                    Senior Vice President and General Counsel


                                       -2-

<PAGE>

                                                                     Exhibit 5.2


                                               April 22, 1996





Bristol-Myers Squibb Company
345 Park Avenue
New York, New York  10154


Ladies and Gentlemen:

                  We have acted as counsel for Bristol-Myers Squibb Company (the
"Company")  in  connection  with the  preparation  of the Form S-8  registration
statement  (the  "Registration  Statement")  being filed with the Securities and
Exchange  Commission  as of the date  hereof in  connection  with an offering of
securities  under  the  Bristol-Myers  Squibb  Company  Savings  and  Investment
Program,  amended  and  restated  effective  October  1, 1994 (the  "SIP"),  the
Bristol-Myers  Squibb  Company  Employee  Incentive  Thrift  Plan,  amended  and
restated  effective  October 1, 1994 (the "EITP") and the  Bristol-Myers  Squibb
Puerto Rico,  Inc.  Savings and Investment  Program,  amended and restated as of
April 15, 1994 (the "PRSIP") (collectively, the "Plans").

                  Each Plan consists of a profit-sharing  and savings  component
and is  intended to qualify  under  Sections  401(a) and 401(k) of the  Internal
Revenue Code of 1986, as amended (the "Code").

<PAGE>



April 22, 1996                         -2-                           Exhibit 5.2



                  In  connection  with  the  preparation  of  the   Registration
Statement,  we  have  examined  originals  or  copies,  certified  or  otherwise
identified to our satisfaction,  of each of the Plans, the Bristol-Myers  Squibb
Company Master  Retirement  Plan Trust  Agreement,  dated August 1, 1989 and the
Bristol-Myers  Squibb Company Savings Plan Master Trust,  dated as of October 1,
1994  (collectively the "Trust  Agreements") and all amendments to the Plans and
the Trust  Agreements  adopted as of the date  hereof  (collectively,  the "Plan
Documents").  We have also examined originals or photostatic or certified copies
of such  additional  records,  instruments and other documents as we have deemed
relevant  and  necessary  as a basis  for such  opinions.  We have  assumed  the
authenticity of all documents submitted to us as originals and the conformity to
original documents of all documents  submitted to us as certified or photostatic
copies.

                  The instructions  relating to Item 8 of Form S-8, by reference
to Item 601 of Regulation  S-K (17 CFR  229.601),  require that either a copy of
the current determination letter from the Internal Revenue Service ("IRS") shall
be filed with the  Securities  and Exchange  Commission or an opinion of counsel
that the provisions of the written  documents  constituting the plan comply with
the  requirements  of the Employee  Retirement  Income  Security Act of 1974, as
amended,  ("ERISA"),  pertaining to such provisions. Such a determination letter
relates  only to a plan's tax status under  Section 401 of the Internal  Revenue
Code of 1986, as amended (the "Code"),  and further relates to a plan's form and
not to its operation. Consequently, this opinion is similarly limited.

                  On  August  7, 1995 the EITP and on August 8, 1995 the SIP and
PRSIP  received  determination  letters issued by the IRS stating that each such
Plan  complies  in form with the  qualification  requirements  applicable  under
Section 401(a) of the Code (collectively,  the "Determination  Letters"). A copy
of each  Determination  Letter is  attached  as an Exhibit to this  letter.  The
Determination  Letters  relating to the SIP and PRSIP were issued subject to the
adoption of certain  qualifying  amendments  submitted by the Company to the IRS
which have since been adopted.  The Determination  Letters did not cover certain
amendments  made to the SIP on June 5,  1995 and June 15,  1995,  to the EITP on
July 18, 1995 and to the PRSIP on June 15, 1995.

                  On June 5, 1995, the SIP was amended  effective May 1, 1995 to
provide  for  qualifying   nonelective   contributions,   to  prescribe  certain
corrective measures relating to certain operational  defects, to provide for the
allocation of any


<PAGE>


April 22, 1996                         -3-                           Exhibit 5.2


recoveries  of claims  filed by the trustee of the SIP on behalf of the SIP, and
to provide  for the merger of the Matrix  Essentials  Inc.  401(k) Plan into the
SIP.  On June 15,  1995,  certain  technical  amendments  were  made to the SIP.
Similar  amendments  to the ones made to the SIP on June 5, 1995 (other than the
Matrix Plan  merger) and July 15, 1995 were made to the EITP on July 18, 1995. A
similar technical amendment was made to the PRSIP on June 15, 1995.

                  Subsequent to the issuance of the Determination  Letters,  the
SIP and EITP were the subject of requests submitted by the Company to the IRS on
December 22, 1995 under the IRS Voluntary Compliance Resolution ("VCR") Program.
As part of the VCR request, the Company submitted the amendments made on June 5,
1995 to the SIP and on July 18, 1995 to the EITP.  In  response,  the IRS issued
Compliance  Statements  dated  March 1, 1996,  stating  that it would not pursue
certain  sanctions  against  the SIP or EITP  based on the  corrective  measures
taken.

                  In addition,  subsequent to the issuance of the  Determination
Letters, the PRSIP was amended by two separate  amendments.  First, on September
1, 1995 an Amendment  retroactive  to May 1, 1995 was adopted to provide for the
allocation  of any  recoveries  from claims filed by the trustee of the PRSIP on
behalf of the PRSIP. Second, on December 20, 1995 an amendment effective January
1, 1996 was  adopted to provide  for  participant  plan loans under the PRSIP in
accordance with the requirements applicable under the Code.

                  The Plans are subject to certain  requirements of the Code and
ERISA.  To date only certain final  regulations  have been issued by the IRS and
the U.S.  Department of Labor with respect to the  requirements  of the Code and
ERISA. Accordingly, our opinion concerning compliance of the Plan Documents with
Section 401 of the Code and the portion of ERISA not  amendatory  of the Code is
necessarily based on our present understanding of the applicable requirements of
the Code and ERISA.

                  Subject to the foregoing,  it is our opinion that (i) the Plan
Documents are in substantial compliance with the requirements of Sections 401(a)
and 401(k) of the Code,  and (ii) the Plan Documents  substantially  comply with
the  applicable  portions of ERISA which are not  amendatory  of the Code.  This
opinion is  limited to the form of the Plan  Documents  and is not  intended  to
address the operation of the Plans or the Trusts thereunder.

<PAGE>


April 22, 1996                         -4-                           Exhibit 5.2


                  This opinion has been issued to the Company in connection with
the  filing of the  Registration  Statement  with the  Securities  and  Exchange
Commission  and it may not be relied  upon by any  other  party or for any other
purpose.  We hereby  consent  to the use of this  opinion  as an  Exhibit to the
Registration Statement.


                                         Very truly yours,

                                         /s/ Winthrop, Stimson, Putnam & Roberts
                                         ---------------------------------------

<PAGE>

                              Registration No. 33-
        -----------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549
                                ----------------

                                    Form S-8

                           REGISTRATION STATEMENT (1)
                                      Under
                           THE SECURITIES ACT OF 1933
                                ----------------

                          BRISTOL-MYERS SQUIBB COMPANY

               (Exact name of issuer as specified in its charter)

Delaware                                               22-0790350
(State of Incorporation)                    (I.R.S. Employer Identification No.)

                                 345 Park Avenue
                            New York, New York 10154
                                 (212) 546-4000
          (Address and telephone number of principal executive offices)


           BRISTOL-MYERS SQUIBB COMPANY SAVINGS AND INVESTMENT PROGRAM
           BRISTOL-MYERS SQUIBB COMPANY EMPLOYEE INCENTIVE THRIFT PLAN
      BRISTOL-MYERS SQUIBB PUERTO RICO, INC. SAVINGS AND INVESTMENT PROGRAM

                              (Full Title of Plans)

                                 ---------------

John L. McGoldrick, Esq.                            Alice C. Brennan, Esq.
Senior Vice President and General Counsel           Vice President and Secretary

                          Bristol-Myers Squibb Company
                                 345 Park Avenue
                            New York, New York 10154
                                 (212) 546-4000
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                                    Copy to:

                       Winthrop, Stimson, Putnam & Roberts
                             One Battery Park Plaza
                          New York, New York 10004-1490
                                 (212) 858-1125
                        Attention: Susan P. Serota, Esq.


                         CALCULATION OF REGISTRATION FEE
================================================================================


Title of                      Proposed Maximum Proposed Maximum     Amount of
Securities to   Amount to be  Offering Price   Aggregate Offering   Registration
be Registered   Registered    Per Share (2)    Price (2)            Fee (2)
- --------------------------------------------------------------------------------
Common Stock,
par value $.10
per share ....  6,000,000     $80.875         $485,250,000          $167,328

================================================================================

<PAGE>

(1)      In addition,  pursuant to Rule 416(c) under the Securities Act of 1933,
         this  Registration  Statement  also covers an  indeterminate  amount of
         interests to be offered or sold  pursuant to the employee  benefit plan
         described herein.  This Registration  Statement also pertains to Rights
         to Purchase  shares of Series A  Participating  Preferred  Stock of the
         Registrant (the "Rights").  Until the occurrence of certain  prescribed
         events,   the  Rights  are  not  exercisable,   are  evidenced  by  the
         certificates for Bristol-Myers  Squibb Company Common Stock and will be
         transferred  along  with and only  with  such  securities.  Thereafter,
         separate Rights  certificates will be issued representing one Right for
         each share of Bristol-Myers Squibb Company Common Stock held subject to
         adjustment pursuant to anti-dilution provisions.

(2)      Estimated  solely for the purpose of determining the  registration  fee
         and computed  pursuant to Rule 457(h),  the maximum price per share and
         the  registration fee are based on the reported average of the high and
         low prices,  for  Bristol-Myers  Squibb Company Common Stock on the New
         York Stock Exchange on April 17, 1996.


                                       -2-

<PAGE>


Item 3.  Incorporation of Documents by Reference.

                  This  Registration  Statement  on Form S-8 (the  "Registration
Statement")  filed in  connection  with the  issuance  of  additional  shares of
Bristol-Myers Squibb Company Common Stock under the Bristol-Myers Squibb Company
Savings and Investment Program,  Bristol-Myers Squibb Company Employee Incentive
Thrift  Plan  and  the  Bristol-Myers  Squibb  Puerto  Rico,  Inc.  Savings  and
Investment Program (the "Plans") constitutes a new registration  statement.  The
contents of the Registration Statement on Form S-8, File No. 33-44788,  filed by
Bristol-Myers  Squibb Company (the  "Company")  with the Securities and Exchange
Commission pursuant to the Securities Act of 1933, as amended,  are incorporated
by reference herein.



Item 8.  Exhibits.

Exhibit No.                Description
- -----------                -----------

5.1                        Opinion  from  Counsel  for  the  Company  as to  the
                           legality of the Company's  Common Stock offered under
                           the Plans.

5.2                        Opinion  from  Counsel for the Company that the Plans
                           are qualified  under  Section  401(a) of the Internal
                           Revenue   Code  of  1986,   as  amended  and  are  in
                           compliance  with  the  Employee   Retirement   Income
                           Security Act of 1974, as amended.

23.1                       Consent   of  Price   Waterhouse   LLP,   independent
                           accountants.

23.2                       Consent  of Counsel  for the  Company  (contained  in
                           Opinion of Counsel filed as Exhibit 5.1).

23.3                       Consent  of Counsel  for the  Company  (contained  in
                           Opinion of Counsel filed as Exhibit 5.2).

24.1                       Power of Attorney  (set forth on  signature  pages of
                           the Registration Statement)

24.2                       Certified  resolutions  of the Board of  Directors of
                           Bristol-Myers  Squibb  Company  relating  to Power of
                           Attorney  set  forth  on the  signature  pages of the
                           Registration Statement.


                                       -1-

<PAGE>

                                   SIGNATURES


                  Pursuant to the  requirements  of the  Securities Act of 1933,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized,  in the  City of New  York,  State of New  York,  on the  25th
day of April, 1996.



                                    BRISTOL-MYERS SQUIBB COMPANY,


                                    By  /s/ Charles A. Heimbold, Jr.
                                       -----------------------------
                                      Charles A. Heimbold, Jr.
                                      President, Chief Executive
                                      Officer, Chairman of the
                                      Board and Director



                                POWER OF ATTORNEY


                  Know  all by men by  these  presents,  that  each  officer  or
director  of  Bristol-Myers  Squibb  Company,   whose  signature  appears  below
constitutes  and appoints  Alice C. Brennan,  John L.  McGoldrick,  Frederick S.
Schiff  and  Charles  G.  Tharp  and each of them  singly,  his true and  lawful
attorney-in-fact and agent, with full and several power of substitution, for him
and in  his  name,  place  and  stead,  in any  an  all  capacities,  to  sign a
Registration Statement on Form S-8 to be filed pursuant to the Securities Act of
1933 in connection  with the  registration  of up to 6,000,000  shares of Common
Stock, par value $.10 per share,  and any or all amendments,  including pre- and
post-effective amendments and supplements to this Registration Statement, and to
file the same,  with all exhibits  thereto,  and other  documents in  connection
therewith,  with the  Securities  and Exchange  Commission,  granting  unto said
attorney-in-fact  and agent full power and  authority to do and perform each and
every  act and  thing  requisite  and  necessary  to be done  in and  about  the
premises,  as  fully  to all  intents  and  purposes  as he might or could do in
person, hereby ratifying and confirming all that said attorney-in-fact and agent
or his substitute or  substitutes,  may lawfully do or cause to be done. Each of
said  attorneys-in-fact  shall have power to act  hereunder  with or without the
other.



                                       -2-

<PAGE>



                  Pursuant to the  requirements  of the  Securities Act of 1933,
this Form S-8 has been signed by the following  persons in the capacities and on
the date indicated:


Signature                                   Title                        Date
- ---------                                   -----                        ----


/s/ Charles A. Heimbold, Jr.                President, Chief             4/25/96
- ----------------------------                Executive Officer,
Charles A. Heimbold, Jr.                    Chairman of the
                                            Board and Director
                                            (principal executive
                                            officer)

/s/ Michael F. Mee                          Corporate Staff              4/25/96
- ------------------                          Senior Vice President
Michael F. Mee                              and Chief Financial
                                            Officer (principal
                                            financial officer)


/s/ Frederick S. Schiff                     Corporate Staff              4/25/96
- -----------------------                     Vice President
Frederick S. Schiff                         and Controller
                                            (principal
                                            accounting officer)

/s/ Robert E. Allen                         Director                     4/25/96
- -------------------
Robert E. Allen


/s/ Michael E. Autera                       Executive Vice               4/25/96
- ---------------------                       President and
Michael E. Autera                           Director

/s/ Ellen V. Futter                         Director                     4/25/96
- -------------------
Ellen V. Futter


/s/ Louis V. Gerstner, Jr.                  Director                     4/25/96
- --------------------------
Louis V. Gerstner, Jr.


/s/ John D. Macomber                        Director                     4/25/96
- --------------------
John D. Macomber

                                       -3-

<PAGE>

Signature                                   Title                        Date
- ---------                                   -----                        ----


/s/ James D. Robinson III                   Director                     4/25/96
- -------------------------
James D. Robinson III



/s/ Andrew C. Sigler                        Director                     4/25/96
- --------------------
Andrew C. Sigler



/s/ Louis W. Sullivan, M.D.                 Director                     4/25/96
- ---------------------------
Louis W. Sullivan, M.D.



/s/ Kenneth E. Weg                          Executive Vice               4/25/96
- ------------------                          President and
Kenneth E. Weg                              Director



By /s/ Alice C. Brennan
   --------------------
   Alice C. Brennan
   Attorney-in-Fact



                                       -4-

<PAGE>



                  THE PLANS.  Pursuant to the requirements of the Securities Act
of 1933, the Plans have duly caused the  Registration  Statement to be signed on
their behalf by the undersigned,  thereunto duly authorized,  in the City of New
York, and the State of New York, on the 25th day of April, 1996.

BRISTOL-MYERS SQUIBB COMPANY SAVINGS
AND INVESTMENT PROGRAM
BRISTOL-MYERS SQUIBB COMPANY EMPLOYEE
INCENTIVE THRIFT PLAN
BRISTOL-MYERS SQUIBB PUERTO RICO, INC.
SAVING AND INVESTMENT PROGRAM

BY:  BRISTOL-MYERS SQUIBB COMPANY
     SAVINGS PLAN COMMITTEE


Signature                                   Title
- ---------                                   ------

/s/ Michael F. Mee                          Senior Vice President*
- ------------------
Michael F. Mee


/s/ Harrison M. Bains, Jr.                  Vice President and
- --------------------------                  Treasurer*
Harrison M. Bains, Jr.

/s/ Alice C. Brennan                        Vice President and
- --------------------                        Secretary*
Alice C. Brennan  

/s/ Robert B. Chapman, Jr.                  Director, Pension
- --------------------------                  & Savings Investment
Robert B. Chapman, Jr.                      Management*

/s/ John D. Glover                          Vice President*
- ------------------
John D. Glover


/s/ George P. Kooluris                      Senior Vice President*
- ----------------------
George P. Kooluris


/s/ John L. McGoldrick                      Senior Vice President*
- ----------------------
John L. McGoldrick

                                       -5-

<PAGE>



Signature                                   Title
- ---------                                   -----

/s/ Frederick S. Schiff                     Vice President and
- -----------------------                     Controller*
Frederick S. Schiff 

/s/ Charles G. Tharp                        Senior Vice President*
- --------------------
Charles G. Tharp



- --------
*        Members of Bristol-Myers Squibb Company Savings Plan Committee, signing
         in that capacity on behalf of the Bristol-Myers  Squibb Company Savings
         and Investment  Program,  the  Bristol-Myers  Squibb  Company  Employee
         Incentive  Thrift Plan and the  Bristol-Myers  Squibb Puerto Rico, Inc.
         Savings and Investment Program.

                                       -6-

<PAGE>


                                                                    EXHIBIT 23.1


                       CONSENT OF INDEPENDENT ACCOUNTANTS
                       ----------------------------------


                  We hereby  consent to the  incorporation  by  reference in the
Prospectus  constituting part of this Registration  Statement on Form S-8 of our
report  dated  January 23, 1996  appearing  on page 51 of  Bristol-Myers  Squibb
Company's  Annual  Report on Form 10-K for the year ended  December 31, 1995. We
also  consent  to the  reference  to us  under  the  heading  "Experts"  in such
Prospectus.




                                       -7-

<PAGE>


                              PRICE WATERHOUSE LLP


                               New York, New York
                                 April 22, 1996


<PAGE>


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