ABBOTT LABORATORIES
SC 13D/A, 1998-12-17
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                 SCHEDULE 13D

                 Under the Securities Exchange Act of 1934
                            (Amendment No. 2)*
                                          ---

                    La Jolla Pharmaceutical Company
           --------------------------------------------------------
                                (Name of Issuer)

                  Common Stock, par value $.01 per share
           --------------------------------------------------------
                          (Title of Class of Securities)

                            503  459  10  9
           --------------------------------------------------------
                                 (CUSIP Number)

              Jose M. de Lasa, Abbott Laboratories, AP6D D-364,
           100 Abbott Park Road; Abbott Park, Illinois 60064-3500;
                             phone (847) 937-8905
           --------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                October 22, 1998
           --------------------------------------------------------
            (Date of Event which Requires Filing of this Statement)

   If the  filing  person has  previously filed a  statement on Schedule 13G to
report the  acquisition  which  is the  subject  of this  Schedule 13D,  and is
filing this  schedule  because of Rule 13d-1(b)(3) or (4),  check the following
box / /.

   NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

   *The remainder of  this cover  page  shall  be  filled  out  for a reporting
person's  initial  filing on this  form with  respect to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter disclosures provided in a prior cover page.

   The information  required on the  remainder of this  cover page shall not be
deemed to be "filed"  for the purpose of  Section 18 of the Securities Exchange
Act of 1934  ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however, see
the Notes).


                        (Continued on following page(s))

                              Page 1 of 6 Pages
                                       ---

<PAGE>

CUSIP No. 503459109                   13D                 Page  2  of  6  Pages
          ---------                                            ---    --- 


- -------------------------------------------------------------------------------
 (1) Names of Reporting Persons.  S.S. or I.R.S. Identification Nos. of Above
     Persons (entities only)

     Abbott Laboratories
     IRS Identification Number: 36-0698440
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  /X/
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Source of Funds*

     WC
- -------------------------------------------------------------------------------
 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to
     Items 2(d) or 2(e)
- -------------------------------------------------------------------------------
 (6) Citizenship or Place of Organization

     Illinois
- -------------------------------------------------------------------------------
Number of Shares              (7) Sole Voting
 Beneficially Owned                 Power                     3,369,604
 by Each Reporting           --------------------------------------------------
 Person With                  (8) Shared Voting
                                    Power
                             --------------------------------------------------
                              (9) Sole Dispositive
                                    Power                     3,369,604
                             --------------------------------------------------
                             (10) Shared Dispositive
                                    Power
- -------------------------------------------------------------------------------
(11) Aggregate Amount Beneficially Owned by Each Reporting Person
     3,369,604
- -------------------------------------------------------------------------------
(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares*
     (See instructions)
- -------------------------------------------------------------------------------
(13) Percent of Class Represented by Amount in Row (11)
     16.78%
- -------------------------------------------------------------------------------
(14) Type of Reporting Person*
     CO
- -------------------------------------------------------------------------------

<PAGE>

The following information amends and supplements the Schedule 13D filed on
January 2, 1997 (the "Schedule 13D") and the First Amendment to the Schedule 13D
filed September 26, 1997 (the "First Amendment").

ITEM 1.   SECURITY AND ISSUER

          This statement relates to the common stock, par value $.01 per share
(the "Common Stock"), of La Jolla Pharmaceutical Company, a Delaware corporation
(the "Issuer"), whose principal executive offices are located at 6455 Nancy
Ridge Drive, San Diego, California 92121.

ITEM 2.        IDENTITY AND BACKGROUND

          (a) - (c), and (f)  The person filing this statement is Abbott
Laboratories ("Abbott"), an Illinois corporation.  Abbott's principal business
is the discovery, development, manufacture, and sale of a broad and diversified
line of health care products and services.  Abbott's principal office is located
at 100 Abbott Park Road, Abbott Park, Illinois 60064-3500.

          The names, citizenship, business addresses, present principal
occupation or employment and the name, and the principal business and address of
any corporation or other organization in which such employment is conducted of
the directors and executive officers of Abbott are as set forth in Exhibit 1
hereto and incorporated herein by this reference.

          (d) and (e)    Neither Abbott, nor to the best of its knowledge, any
person listed on Exhibit 1 has during the last five years (i) been convicted in
a criminal proceeding (excluding traffic violations or similar misdemeanors) or
(ii) been a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction and as a result of such proceeding was or is subject to a
judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, federal or state securities laws or finding
any violation with respect to such laws.

ITEM 3.   SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

          The consideration used by Abbott for the acquisition reported in this
Second Amendment to Schedule 13D came from the working capital of Abbott.  The
aggregate purchase price for the 1,538,402 shares of Common Stock acquired by
Abbott since the date on which the First Amendment was filed, as described in
Item 4, was four million dollars ($4,000,000).  The aggregate purchase price for
the 3,369,604 shares of Common stock owned by Abbott is twelve million dollars
($12,000,000) all of which came from the working capital of Abbott.

                                      -3-

<PAGE>

          K. Frank Austen, M.D., a director of Abbott, has advised Abbott that
he is the beneficial owner of 2,500 shares of Common Stock, that he holds
options to purchase an additional 36,300 shares of Common Stock (of which,
options covering 11,800 shares of Common Stock are currently exercisable) and
that he used his personal assets to acquire his shares of Common Stock.  Dr.
Austen acquired these securities independently of Abbott's acquisitions.

ITEM 4.   PURPOSE OF THE ACQUISITION

          On October 22, 1998, as the result of the exercise by the Issuer of
its Additional Investment Right (described below), Abbott purchased 1,538,402
shares (the "Shares") of Common Stock.  Abbott acquired the Shares as an
investment and is bound by the terms and conditions of the Agreement between
Abbott Laboratories and La Jolla Pharmaceutical Company dated December 23, 1996
(the "Agreement") (a copy of which is attached to the Schedule 13D as Exhibit
2).  Dr. Austen has advised Abbott that he acquired his shares of Common Stock
as an investment.

          (a) Under Section 2(b) of the Agreement, the Issuer had the right (the
"Additional Investment Right") to require Abbott to purchase additional shares
of the Issuer's Common Stock.  The Additional Investment Right is described in
greater detail in Item 6 of the Schedule 13D.

          (b) - (j) At present, Abbott does not have (and has been advised by
Dr. Austen that he does not have) any plans or proposals which would relate to
or result in transactions of the kind described in paragraphs (b) through (j) of
Item 4 of schedule 13D of the Securities and Exchange Commission.  They do,
however, reserve the right to adopt such plans or proposals subject to
compliance with applicable regulatory requirements and, with respect to Abbott,
its obligations under the Agreement.

ITEM 5.   INTEREST IN SECURITIES OF THE ISSUER

          (a)  Abbott is the beneficial owner of 3,369,604 shares of the Common
Stock representing approximately sixteen and 78/100 percent (16.78%) of the
outstanding shares of the Common Stock.

          Dr. Austen is the beneficial owner of the shares of Common Stock and
options described in Item 3.  His shares represent less than one percent of the
outstanding shares of the Common Stock.

          The calculation of the foregoing percentages is based on the number of
shares of Common Stock shown as being outstanding on the Form 10-Q Quarterly
Report filed by the Issuer with the Securities and Exchange Commission for the
quarter ended September 30, 1998.

                                      -4-

<PAGE>

          (b) Abbott has sole power to vote or to direct the vote and the sole
power to dispose or to direct the disposition of its 3,369,604 shares of Common
Stock.  Section 5(b) of the Agreement does, however, limit the ability of Abbott
to sell or transfer any Shares except as allowed by the Agreement.

               K. Frank Austen, M.D., a director of Abbott Laboratories, has
advised Abbott that he is the beneficial owner of 2,500 shares of Common Stock
and holds options to purchase an additional 36,300 shares of Common Stock (of
which, options covering 11,800 shares of Common Stock are currently exercisable)
and that he has sole power to vote or to direct the vote and the sole power to
dispose or to direct the disposition of his shares of Common Stock.

          (c)  Except as described herein, there have been no transactions by
Abbott or the persons whose names are listed on Exhibit 1 in securities of the
Issuer during the past sixty days.

          (d)  No one other than Abbott is known to have the right to receive or
the power to direct the receipt of dividends from, or the proceeds from a sale
of the Shares.

          (e)  Not applicable.

ITEM 6.   CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
          RESPECT TO SECURITIES OF THE ISSUER

          There are no contracts, arrangements, understandings or relationships
among the persons named in Item 2 or between either of those persons and any
other person with respect to securities of the Issuer, except as referred to or
described herein or in the Schedule 13D.

ITEM 7.   MATERIAL TO BE FILED AS EXHIBITS

          Exhibit 1 - Information Concerning Executive Officers and
                      Directors of Abbott Laboratories.

               *******************************

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                     Abbott Laboratories

DATED: December 16, 1998             By: /s/ Thomas C. Freyman
                                         --------------------------------------

                                         Thomas C. Freyman, Vice President and
                                         Treasurer

                                      -5-

<PAGE>

EXHIBIT INDEX

<TABLE>
<CAPTION>
                                                                SEQUENTIAL PAGE
EXHIBIT NUMBER   DESCRIPTION                                    NUMBER
- --------------   -----------                                    ---------------
<S>              <C>                                            <C>

     1           Information Concerning Executive Officers and
                 Directors of Abbott Laboratories.
</TABLE>














                                      -6-


<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

     The current corporate officers and directors of Abbott Laboratories are
listed below.  The address of Abbott Laboratories is:  Abbott Laboratories, 100
Abbott Park Road, Abbott Park, Illinois 60064-3500.  Abbott Laboratories does
not consider all of its corporate officers to be executive officers as defined
by the Securities Exchange Act of 1934 or Releases thereunder.  Unless otherwise
indicated, all positions set forth below opposite an individual's name refer to
positions within Abbott Laboratories, and the business address listed for each
individual not principally employed by Abbott Laboratories is also the address
of the corporation or other organization which principally employs that
individual.

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL          CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>

Corporate Officers
- ------------------
Duane L. Burnham(1)            Chairman of the Board and Chief         U. S. A.
                               Executive Officer

Thomas R. Hodgson(1)           President and Chief Operating           U. S. A.
                               Officer

Miles D. White(1)              Executive Vice President                U. S. A.

Robert L. Parkinson, Jr.(1)    Executive Vice President                U. S. A.

Joy Amundson(1)                Senior Vice President, Ross Products    U. S. A.

Thomas D. Brown(1)             Senior Vice President, Diagnostic       U. S. A.
                               Operations

Gary P. Coughlan(1)            Senior Vice President, Finance &        U. S. A.
                               Chief Financial Officer

Jose M. de Lasa(1)             Senior Vice President, Secretary &      U. S. A.
                               General Counsel

William G. Dempsey(1)          Senior Vice President, Chemical &       U. S. A.
                               Agricultural Products

Richard A. Gonzalez(1)         Senior Vice President, Hospital         U. S. A.
                               Products

Arthur J. Higgins(1)           Senior Vice President,                   United
                               Pharmaceutical Operations                Kingdom

Ellen M. Walvoord(1)           Senior Vice President, Human            U. S. A.
                               Resources

Josef Wendler(1)               Senior Vice President, International     Germany
                               Operations
</TABLE>

                                     -7-

<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL          CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>
Corporate Officers
- ------------------
      - continued

Catherine V. Babington(1)      Vice President, Investor Relations      U. S. A.
                               and Public Affairs

Patrick J. Balthrop            Vice President, Diagnostic              U. S. A.
                               Commercial Operations

Mark E. Barmak                 Vice President, Litigation and          U. S. A.
                               Government Affairs

Christopher B. Begley(1)       Vice President, Abbott HealthSystems    U. S. A.

Douglas C. Bryant              Vice President, Diagnostic              U. S. A.
                               Operations, Asia and Pacific

Gary R. Byers(1)               Vice President, Internal Audit          U. S. A.

Thomas R. Chen                 Vice President, Pacific, Asia and       U. S. A.
                               Africa Operations

Kenneth W. Farmer(1)           Vice President, Management              U. S. A.
                               Information Services &
                               Administration

Edward J. Fiorentino           Vice President, Pharmaceutical          U. S. A.
                               Products, Marketing and Sales

Thomas C. Freyman(1)           Vice President and Treasurer            U. S. A.

David B. Goffredo              Vice President, European Operations     U. S. A.

Guillermo A. Herrera           Vice President, Latin America and       Colombia
                               Canada Operations

Jay B. Johnston                Vice President, Diagnostic Assays       U. S. A.
                               and Systems

James J. Koziarz               Vice President, Diagnostic Products     U. S. A.
                               Research and Development

John F. Lussen(1)              Vice President, Taxes                   U. S. A.
</TABLE>

                                      -8-

<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL          CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>
Corporate Officers
- ------------------
      - continued

Edward L. Michael              Vice President, Diagnostic              U. S. A.
                               Operations, Europe, Africa and
                               Middle East

Theodore A. Olson(1)           Vice President and Controller           U. S. A.

Andre G. Pernet                Vice President, Pharmaceutical          U. S. A.
                               Products Research and Development

William H. Stadtlander         Vice President, Ross Medical            U. S. A.
                               Nutritional Products

Marcia A. Thomas               Vice President, Corporate Quality       U. S. A.
                               Assurance and Regulatory Affairs

Steven J. Weger, Jr.(1)        Vice President, Corporate Planning      U. S. A.
                               and Development

Susan M. Widner                Vice President, Diagnostic              U. S. A.
                               Operations, U.S. and Canada

Lance B. Wyatt(1)              Vice President, Corporate               U. S. A.
                               Engineering
</TABLE>

                                      -9-

<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL        CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>
Directors
- ---------

K. Frank Austen, M.D.               Smith Building                     U. S. A.
                                    Room 638
                                    75 Francis Street
                                    Boston, Massachusetts 02115

Duane L. Burnham               Officer of Abbott                       U. S. A.

H. Laurance Fuller             Chairman and Chief Executive            U. S. A.
                               Officer
                                    Amoco Corporation
                                    200 East Randolph Drive
                                    Mail Code 3000
                                    Chicago, Illinois 60601

Thomas R. Hodgson              Officer of Abbott                       U. S. A.

David A. Jones                 Chairman of the Board                   U. S. A.
                                    Humana, Inc.
                                    500 W. Main Street
                                    Humana Building
                                    Louisville, Kentucky 40202

The Rt. Hon. Lord Owen CH      Physician, Politician, and           United Kingdom
                               Businessman
                                    House of Lords
                                    Westminster, London
                                    SW1A OPW, England

Robert L. Parkinson, Jr.       Officer of Abbott                       U. S. A.
</TABLE>

                                     -10-

<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL        CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>
Directors - continued
- ---------

Boone Powell, Jr.              President and Chief Executive           U. S. A.
                               Officer
                                    Baylor Health Care System and
                                    Baylor University Medical
                                    Center
                                    3500 Gaston Avenue
                                    Dallas, Texas 75246

Addison Barry Rand             Executive Vice President                U. S. A.
                                    Xerox Corporation
                                    800 Long Ridge Road
                                    Stamford, Connecticut 06904-
                                    1600

W. Ann Reynolds, Ph.D.         President                               U. S. A.
                                    The University of Alabama at
                                    Birmingham
                                    701 South 20th Street
                                    Birmingham, Alabama 35294-
                                    0110

Roy S. Roberts                 Vice President, and Group              U. S. A.
                               Executive, North American
                               Vehicle Sales, Service
                               and Marketing
                                    General Motors Corporation
                                    100 Renaissance Center
                                    Mail Code 482-A30-D10
                                    Detroit, Michigan 48243

William D. Smithburg           Retired Chairman, President and         U. S. A.
                               Chief Executive Officer, The
                               Quaker Oats Company
                                    676 N. Michigan Avenue
                                    Suite 3860
                                    Chicago, Illinois 60611

John R. Walter                 Chairman Ashlin Management Corp.        U. S. A.
                                    100 South Wacker Drive
                                    Suite 2100
                                    Chicago, IL 60606

</TABLE>

                                     -11-

<PAGE>

                                     Exhibit 1

                   Information Concerning Executive Officers and
                          Directors of Abbott Laboratories
                          _______________________________

<TABLE>
<CAPTION>
NAME                           POSITION / PRESENT PRINCIPAL        CITIZENSHIP
                               OCCUPATION OR EMPLOYMENT AND
                               BUSINESS ADDRESS
<S>                            <C>                                   <C>
Directors - continued
- ---------

William L. Weiss               Chairman Emeritus, Ameritech            U. S. A.
                               Corporation
                                    One First National Plaza
                                    Suite 2530C
                                    Chicago, Illinois 60603-2006

Miles D. White                 Officer of Abbott                       U. S. A.
</TABLE>





                                     -12-



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