ABBOTT LABORATORIES
S-4, 1999-08-16
PHARMACEUTICAL PREPARATIONS
Previous: PUTNAM FL INVESTMENT MANAGEMENT CO, 13F-HR, 1999-08-13
Next: ABBOTT LABORATORIES, SC 13D, 1999-08-16



<PAGE>
    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON AUGUST 16, 1999
                                                      REGISTRATION NO. 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------

                                    FORM S-4

            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                            ------------------------

                              ABBOTT LABORATORIES

             (Exact name of Registrant as specified in its charter)

<TABLE>
<S>                              <C>                            <C>
           ILLINOIS                          2834                  36-0698440
 (State or other jurisdiction    (Primary Standard Industrial   (I.R.S. Employer
     of incorporation or         Classification Code Number)     Identification
        organization)                                                 No.)
</TABLE>

                              ABBOTT LABORATORIES
                              100 ABBOTT PARK ROAD
                        ABBOTT PARK, ILLINOIS 60064-6400
                                 (847) 937-6100

         (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)
                           --------------------------

                                JOSE M. DE LASA
              SENIOR VICE PRESIDENT, SECRETARY AND GENERAL COUNSEL
                              100 ABBOTT PARK ROAD
                        ABBOTT PARK, ILLINOIS 60064-6400
                                 (847) 937-6100

           (Name, address, including, zip code and telephone number,
                   including area code, of agent for service)

                           --------------------------

                                    Copy to:

<TABLE>
<S>                                   <C>                                   <C>
            SCOTT J. DAVIS                       SARAH A. O'DOWD                      BRIAN J. MCCARTHY
          PHILIP J. NIEHOFF                      RICHARD A. PEERS              SKADDEN, ARPS, SLATE, MEAGHER &
         MAYER, BROWN & PLATT            HELLER EHRMAN WHITE & MCAULIFFE                   FLOM LLP
       190 SOUTH LASALLE STREET               525 UNIVERSITY AVENUE                 300 SOUTH GRAND AVENUE
     CHICAGO, ILLINOIS 60603-3441          PALO ALTO, CALIFORNIA 94301                    SUITE 3400
            (312) 782-0600                        (650) 324-7000                LOS ANGELES, CALIFORNIA 90071
                                                                                        (213) 687-5000
</TABLE>

    APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE OF THE SECURITIES TO THE
PUBLIC: As soon as practicable following the effectiveness of this Registration
Statement.

    If the securities being registered on this Form are being offered in
connection with the formation of a holding company and there is compliance with
General Instruction G, check the following box. / /

    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. / /

    If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /

                         ------------------------------

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
                                                             PROPOSED MAXIMUM    PROPOSED MAXIMUM       AMOUNT OF
        TITLE OF EACH CLASS OF             AMOUNT TO BE     OFFERING PRICE PER  AGGREGATE OFFERING     REGISTRATION
    SECURITIES TO BE REGISTERED(1)          REGISTERED           SHARE(2)            PRICE(2)             FEE(3)
<S>                                     <C>                 <C>                 <C>                 <C>
Common Shares, without par value......  164,750,000 Shares       $41.625          $6,857,718,750        $1,906,446
</TABLE>

(1) This Registration Statement relates to the common shares of Abbott
    Laboratories to be issued in exchange for the outstanding shares of common
    stock, convertible debentures, warrants and options of ALZA Corporation
    pursuant to the merger described in the proxy statement/prospectus included
    herein.

(2) Estimated solely for the purpose of calculating the registration fee
    pursuant to Rule 457(f), based on the market value of the Abbott common
    shares to be received in the exchange using the average of the low and high
    sales prices of Abbott common shares as reported on the New York Stock
    Exchange Composite Tape on August 12, 1999.

(3) Pursuant to Rule 457(b), $1,359,965 of the registration fee that was
    previously paid pursuant to Section 14(g) of the Securities Exchange Act of
    1934, as amended, in connection with the filing of preliminary proxy
    materials on July 14, 1999 has been credited against the registration fee
    payable in connection with this filing.

                         ------------------------------

    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
                                     [LOGO]

                            ------------------------

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

                            ------------------------

                          TUESDAY, SEPTEMBER 21, 1999
                                   9:00 A.M.

To ALZA Corporation stockholders:

    We will hold a meeting of stockholders of ALZA Corporation on Tuesday,
September 21, 1999 at 9:00 a.m. Pacific time, at 1900 Charleston Road, Mountain
View, California. The purpose of the meeting is:

    1.  to vote on adoption of a merger agreement relating to, and approval of,
       a merger of a subsidiary of Abbott Laboratories with and into ALZA. If
       the stockholders adopt the merger agreement and approve the merger, you
       will receive 1.2 Abbott common shares for each share of ALZA common stock
       you own at the time of the merger. Additional information concerning the
       merger is set forth in the accompanying proxy statement/prospectus and in
       the merger agreement, a copy of which is attached as Annex A to the proxy
       statement/prospectus; and

    2.  to transact such other business related to matters as may properly come
       before the meeting.

    These items of business are described in the attached proxy
statement/prospectus. The record date to determine who is entitled to vote at
the meeting was Monday, August 16, 1999. Only holders of ALZA common stock at
the close of business on the record date are entitled to notice of, and to vote
at, the meeting. If you attend the meeting and wish to vote in person, you may
withdraw your proxy and vote in person.

                                          By Order of the Board of Directors,

                                                       [LOGO]

                                          JULIAN N. STERN
                                          SECRETARY

August 16, 1999
Palo Alto, California

WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON, PLEASE COMPLETE, SIGN,
  DATE AND RETURN THE ENCLOSED PROXY AND RETURN IT AS SOON AS POSSIBLE IN THE
                 ACCOMPANYING SELF-ADDRESSED STAMPED ENVELOPE.
<PAGE>
                                ALZA CORPORATION
                                PROXY STATEMENT

                               ------------------

                              ABBOTT LABORATORIES
                                   PROSPECTUS
                        UP TO 164,750,000 COMMON SHARES

    This proxy statement/prospectus relates to a merger in which you will
receive 1.2 Abbott common shares for each share of ALZA common stock that you
own on the date of the merger.

    ALZA's board of directors is furnishing this proxy statement/prospectus to
you in connection with its solicitation of proxies for use at a meeting of
ALZA's stockholders to be held on Tuesday, September 21, 1999 to adopt the
merger agreement and approve the merger. ALZA's board of directors has
unanimously approved and declared advisable the merger agreement, and recommends
that you vote to adopt the merger agreement and approve the merger. This proxy
statement/prospectus and the accompanying form of proxy are first being mailed
to you on or about August 19, 1999.

    SEE "RISK FACTORS" ON PAGE 14 FOR A DISCUSSION OF RISKS RELEVANT TO THE
MERGER.

    Abbott common shares are traded on the New York Stock Exchange under the
symbol "ABT," and shares of ALZA common stock are traded on the New York Stock
Exchange under the symbol "AZA."

    PLEASE DO NOT SEND YOUR ALZA COMMON STOCK CERTIFICATES WITH THE ENCLOSED
PROXY.

    NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE
ADEQUACY OR ACCURACY OF THIS PROXY STATEMENT/PROSPECTUS. ANY REPRESENTATION TO
THE CONTRARY IS A CRIMINAL OFFENSE AND SHOULD BE REPORTED IMMEDIATELY TO THE
SECURITIES AND EXCHANGE COMMISSION.

                            ------------------------

         The date of this proxy statement/prospectus is August 16, 1999
<PAGE>
    This proxy statement/prospectus incorporates by reference important business
and financial information about both Abbott and ALZA which is not included in or
delivered with this proxy statement/prospectus. See "Additional
Information--Where You Can Find More Information."

    You can obtain any of the documents incorporated by reference in this
document through Abbott or ALZA, as the case may be, or from the Securities and
Exchange Commission through its web site at http://www.sec.gov. Documents
incorporated by reference are available from Abbott and ALZA without charge,
excluding any exhibits to those documents unless the exhibit is specifically
incorporated by reference as an exhibit in this proxy statement/prospectus. You
can obtain documents incorporated by reference in this proxy
statement/prospectus by requesting them in writing or by telephone from the
appropriate company at the following addresses:

<TABLE>
<CAPTION>
                     ABBOTT                            ALZA
- -------------------------------------  -------------------------------------
<S>                                    <C>
           Jose M. de Lasa                        Peter D. Staple
  Senior Vice President, Secretary             Senior Vice President
         and General Counsel                    and General Counsel
         Abbott Laboratories                     ALZA Corporation
        Dept. 364; Bldg. AP6D                   950 Page Mill Road
        100 Abbott Park Road                      P.O. Box 10950
  Abbott Park, Illinois 60064-6020       Palo Alto, California 94303-0802
      Telephone (847) 937-8905               Telephone (650) 494-5000
</TABLE>

    IF YOU WOULD LIKE TO REQUEST DOCUMENTS, PLEASE DO SO BY SEPTEMBER 14, 1999
TO RECEIVE THEM BEFORE THE MEETING. IF YOU REQUEST ANY INCORPORATED DOCUMENTS,
WE WILL MAIL THEM TO YOU BY FIRST CLASS MAIL, OR ANOTHER EQUALLY PROMPT MEANS,
WITHIN ONE BUSINESS DAY AFTER WE RECEIVE YOUR REQUEST.
<PAGE>
                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                               PAGE
                                                                                                             ---------
<S>                                                                                                          <C>
SUMMARY....................................................................................................          1
    The Companies..........................................................................................          1
    What You Will Receive in the Merger....................................................................          1
    Material Federal Income Tax Consequences...............................................................          1
    Market Prices of Abbott Common Shares and ALZA Common Stock on Important Dates.........................          1
    ALZA's Reasons for the Merger..........................................................................          1
    Abbott's Reasons for the Merger........................................................................          2
    No Appraisal Rights....................................................................................          2
    Exchange of Stock Certificates.........................................................................          2
    Comparative Rights of Abbott Shareholders and ALZA Stockholders........................................          2
    Comparative per Share Information......................................................................          4
    The Meeting............................................................................................          6
    Vote Required..........................................................................................          6
    The Merger Agreement and the Merger....................................................................          6
    Co-Promotion Agreements................................................................................          9
    Selected Historical Financial Information of Abbott....................................................         10
    Selected Historical Financial Information of ALZA......................................................         11
    Pro Forma Financial Information of Abbott..............................................................         12

RISK FACTORS...............................................................................................         14
    You will receive 1.2 Abbott common shares despite changes in market value of Abbott common shares or
     ALZA common stock.....................................................................................         14
    Failure to qualify for pooling-of-interests accounting treatment may impact reported operating
     results...............................................................................................         14
    The integration of ALZA into Abbott may be difficult and expensive to achieve..........................         14
    Because Abbott conducts a greater amount of business in more foreign countries than ALZA, Abbott's
     international operations are subject to more foreign regulation and greater economic risk.............         14
    ALZA's client business could be adversely affected by the merger.......................................         15
    Expenses resulting from the merger will be substantial and may affect Abbott's results of
     operations............................................................................................         15

THE COMPANIES..............................................................................................         15
    Abbott Laboratories....................................................................................         15
    ALZA Corporation.......................................................................................         16

THE MEETING................................................................................................         17
    Purpose of the Meeting.................................................................................         17
    Date, Time and Place; Record Date......................................................................         17
    Your Voting Rights.....................................................................................         18
    Giving and Revoking Your Proxy; Costs of Solicitation..................................................         18
    No Appraisal Rights....................................................................................         18

THE MERGER AGREEMENT AND THE MERGER........................................................................         18
    General Description of the Merger......................................................................         18
    Background of the Merger...............................................................................         19
    Reasons for the Merger; Recommendation of ALZA's Board of Directors....................................         20
    Opinion of Chase Securities Inc. to ALZA's Board of Directors..........................................         22
    Opinion of Merrill Lynch & Co. to ALZA's Board of Directors............................................         29
    Structure of the Merger................................................................................         36
</TABLE>

                                       i
<PAGE>
<TABLE>
<CAPTION>
                                                                                                               PAGE
                                                                                                             ---------
<S>                                                                                                          <C>
    When the Merger Becomes Effective......................................................................         36
    Conversion of Stock, Stock Options and Other Awards....................................................         37
    Convertible Debt and Warrants..........................................................................         38
    Representations and Warranties.........................................................................         39
    Certain Covenants......................................................................................         40
    Non-Solicitation of Competing Proposals................................................................         42
    Filings and Other Actions..............................................................................         43
    Conditions to Completion of the Merger.................................................................         43
    Termination of the Merger Agreement....................................................................         44
    Expenses...............................................................................................         46
    Modification or Amendment to the Merger Agreement......................................................         46
    Regulatory Requirements................................................................................         46
    Material Federal Income Tax Consequences...............................................................         46
    Anticipated Accounting Treatment.......................................................................         48
    Resale Restrictions....................................................................................         49
    Interests of ALZA Directors and Officers in the Merger that are Different from Your Interests..........         49
    Co-Promotion Agreements................................................................................         52

MARKET PRICES AND DIVIDEND INFORMATION.....................................................................         52

COMPARISON OF RIGHTS OF ABBOTT SHAREHOLDERS AND ALZA STOCKHOLDERS..........................................         53
    Authorized Capital.....................................................................................         53
    Voting Rights..........................................................................................         54
    Board of Directors.....................................................................................         54
    Number, Election, Vacancy and Removal of Directors.....................................................         54
    Stockholder Action by Written Consent..................................................................         55
    Special Stockholder Meetings...........................................................................         55
    Advance Notice Provisions for Stockholder Proposals Other than Election of Directors...................         55
    Advance Notice Provisions for Stockholder Nominations of Directors.....................................         56
    Transactions with Interested Stockholders..............................................................         57
    Amendments to Certificates of Incorporation and By-Laws................................................         58
    Merger or Sale of Assets...............................................................................         59
    Indemnification........................................................................................         60
    Dividends..............................................................................................         60
    Limitations on Director's Liability....................................................................         61
    Dissenters' or Appraisal Rights........................................................................         61

ADDITIONAL INFORMATION.....................................................................................         62
    Deadline for ALZA Stockholder Proposals and Abbott Shareholder Proposals...............................         62
    Legal Matters..........................................................................................         63
    Experts................................................................................................         63
    Where You Can Find More Information....................................................................         64
    Forward-Looking Statements.............................................................................         66

ANNEXES:
    A--Agreement and Plan of Merger........................................................................        A-1
    B--Fairness Opinion of Chase Securities Inc............................................................        B-1
    C--Fairness Opinion of Merrill Lynch & Co..............................................................        C-1
</TABLE>

                                       ii
<PAGE>
                                    SUMMARY

    THIS SUMMARY HIGHLIGHTS SOME OF THE INFORMATION FROM THIS PROXY
STATEMENT/PROSPECTUS AND MAY NOT CONTAIN ALL OF THE INFORMATION THAT IS
IMPORTANT TO YOU. TO UNDERSTAND THE MERGER FULLY AND FOR A MORE COMPLETE
DESCRIPTION OF THE LEGAL TERMS OF THE MERGER, YOU SHOULD CAREFULLY READ THIS
ENTIRE DOCUMENT, INCLUDING THE ANNEXES AND OTHER DOCUMENTS TO WHICH WE HAVE
REFERRED YOU. SEE "ADDITIONAL INFORMATION-- WHERE YOU CAN FIND MORE INFORMATION"
FOR MORE DETAILS.

THE COMPANIES

ABBOTT LABORATORIES
100 ABBOTT PARK ROAD
ABBOTT PARK, ILLINOIS 60064-6400
TELEPHONE (847) 937-6100
WEBSITE: HTTP://WWW.ABBOTT.COM

    Abbott Laboratories' principal business is the discovery, development,
manufacture and sale of a broad and diversified line of health care products and
services.

ALZA CORPORATION
950 PAGE MILL ROAD
PALO ALTO, CALIFORNIA 94304
TELEPHONE (650) 494-5000
WEBSITE: HTTP://WWW.ALZA.COM

    ALZA is a research-based pharmaceutical company with leading drug delivery
technologies. ALZA applies its technologies to develop pharmaceutical products
with enhanced therapeutic value for its own portfolio and for many of the
world's leading pharmaceutical companies. ALZA's sales and marketing efforts are
currently focused on the urology and oncology fields of medicine.

WHAT YOU WILL RECEIVE IN THE MERGER

    You will receive 1.2 Abbott common shares for each share of ALZA common
stock that you own on the date of the merger. Instead of issuing fractional
Abbott common shares, Abbott will pay cash based on an average of the closing
prices for an Abbott common share for the five New York Stock Exchange trading
days preceding the date of the merger.

MATERIAL FEDERAL INCOME TAX CONSEQUENCES

    Because the merger should be treated as a "reorganization" for federal
income tax purposes, you should not be taxed on the receipt of Abbott common
shares in the merger, but you may be taxed with respect to cash you receive in
lieu of fractional shares. See "The Merger Agreement and the Merger--Material
Federal Income Tax Consequences."

    TAX MATTERS ARE VERY COMPLICATED. THE TAX CONSEQUENCES OF THE MERGER TO YOU
WILL DEPEND ON THE FACTS OF YOUR OWN SITUATION. YOU SHOULD CONSULT YOUR TAX
ADVISORS FOR A FULL UNDERSTANDING OF THE TAX CONSEQUENCES OF THE MERGER TO YOU.

MARKET PRICES OF ABBOTT COMMON SHARES AND ALZA COMMON STOCK ON IMPORTANT DATES

    Abbott common shares are traded on the New York Stock Exchange under the
symbol "ABT," and shares of ALZA common stock are traded on the New York Stock
Exchange under the symbol "AZA." The following table provides the closing per
share sales prices of Abbott common shares and ALZA common stock, as reported on
the New York Stock Exchange Composite Tape, on:

    - June 21, 1999--the business day that Abbott and ALZA announced the terms
      of the merger; and

    - August 13, 1999.

<TABLE>
<CAPTION>
                                 ABBOTT       ALZA
                                 COMMON      COMMON
             DATE                SHARES      STOCK
- ------------------------------  --------   ----------
<S>                             <C>        <C>
June 21, 1999.................   $44 3/16   $46 1/4
August 13, 1999...............   $40 7/8    $47 7/16
</TABLE>

    The value of 1.2 Abbott common shares on June 21, 1999 was $53.03.

ALZA'S REASONS FOR THE MERGER

    ALZA's board of directors believes that the merger will result in a combined
corporation with greater resources to pursue research and development efforts
and to commercialize products. ALZA's board of directors believes

                                       1
<PAGE>
that the merger is fair to and in the best interests of ALZA and its
stockholders.

ABBOTT'S REASONS FOR THE MERGER

    Abbott believes that the combined corporation and its shareholders can
benefit from the merger because the proposed merger brings to Abbott a portfolio
of existing pharmaceutical products and new products that ALZA is developing
that Abbott's larger global organization can distribute now and in the future.
The proposed merger also brings to Abbott strong technology relationships with
pharmaceutical industry partners.

NO APPRAISAL RIGHTS

    You are not entitled to dissenters' or appraisal rights in connection with
the merger. See "The Meeting--No Appraisal Rights."

EXCHANGE OF STOCK CERTIFICATES

    Promptly after the merger takes place, BankBoston, N.A., the exchange agent
for this transaction, will send you a letter of transmittal for you to use in
exchanging your ALZA common stock certificates for Abbott common share
certificates. You should not send in your ALZA common stock certificates until
you receive the letter of transmittal. See "The Merger Agreement and the
Merger--Conversion of Stock, Stock Options and Other Awards."

COMPARATIVE RIGHTS OF ABBOTT SHAREHOLDERS AND ALZA STOCKHOLDERS

    Even though Abbott is an Illinois corporation and ALZA is a Delaware
corporation, some of your rights as a shareholder of Abbott will be the same as
your rights as a stockholder of ALZA. There are, however, several important
differences. The following table summarizes some of those differences:

<TABLE>
<CAPTION>
                                                     ABBOTT                                 ALZA
                                      ------------------------------------  ------------------------------------
<S>                                   <C>                                   <C>
CAN STOCKHOLDERS TAKE CORPORATE       Yes, if the holders of a majority of  No, the holders of ALZA's common
  ACTION WITHOUT HOLDING A MEETING?   Abbott's common shares entitled to    stock may only take corporate action
                                      vote at a meeting sign a written      at a stockholders' meeting.
                                      consent to such corporate action.

CAN STOCKHOLDERS CALL MEETINGS?       Yes, by holders of not less than      No, only ALZA's board of directors,
                                      one-fifth of Abbott's common shares   chairman or president can call a
                                      entitled to vote at the meeting.      stockholders' meeting.

CAN STOCKHOLDERS CUMULATE THEIR       Yes, a holder of Abbott's common      No, a holder of ALZA common stock
  VOTES WHEN ELECTING DIRECTORS?      shares may cast all of his or her     must cast each of his or her votes
                                      votes for one director candidate or   for or against each director
                                      may distribute those votes in any     candidate instead of cumulating
                                      proportion among the director         those votes for any one director
                                      candidates.                           candidate.

IS THE BOARD OF DIRECTORS DIVIDED     No, Abbott's entire board of          Yes, ALZA's board of directors is
  INTO SEPARATE CLASSES?              directors is elected each year.       divided into three classes, with one
                                                                            class elected each year.
</TABLE>

                                       2
<PAGE>

<TABLE>
<CAPTION>
                                                     ABBOTT                                 ALZA
                                      ------------------------------------  ------------------------------------
<S>                                   <C>                                   <C>
CAN STOCKHOLDERS REMOVE A DIRECTOR?   Yes, if the holders of a majority of  Yes, but only for "cause" upon the
                                      Abbott's common shares vote to        vote of a majority of ALZA's common
                                      remove that director, unless the      stock.
                                      votes cast against that director's
                                      removal would be sufficient, when
                                      cumulated, to elect that director.

WHAT ACTION IS REQUIRED TO MERGE OR   Approval of not less than two- thirds Approval of a majority of the voting
  SELL SUBSTANTIAL AMOUNTS OF         of the voting power of Abbott's       power of ALZA's outstanding common
  CORPORATE ASSETS?                   outstanding common shares is          stock is required to approve a
                                      required to approve a merger or the   merger or the sale of all or
                                      sale of all or substantially all of   substantially all of ALZA's assets,
                                      Abbott's assets.                      unless the transaction is with a
                                                                            substantial stockholder, in which
                                                                            case approval of 80% of ALZA's
                                                                            outstanding common stock is
                                                                            required.

WHAT ACTION IS REQUIRED TO AMEND      Approval of Abbott's board of         Approval of ALZA's board of
  ABBOTT'S ARTICLES OF INCORPORATION  directors and not less than two-      directors and a majority of the
  OR ALZA'S CERTIFICATE OF            thirds of the shares entitled to      shares entitled to vote on that
  INCORPORATION?                      vote on amendment is required to      amendment is required to approve an
                                      approve an amendment to Abbott's      amendment to ALZA's certificate of
                                      articles of incorporation.            incorporation, except that a higher
                                                                            vote is required for amendments
                                                                            relating to business combinations
                                                                            and the number, classification, term
                                                                            of office and filling of vacancies
                                                                            on ALZA's board of directors.
                                      ------------------------------------  ------------------------------------
</TABLE>

                                       3
<PAGE>
COMPARATIVE PER SHARE INFORMATION

    The following table summarizes certain historical financial information and
unaudited pro forma and equivalent pro forma financial information on a per
share basis.

    The unaudited pro forma financial information assumes that the merger was
completed at the beginning of each of the periods presented and gives effect to
the merger as a pooling-of-interests for accounting purposes. The basic
unaudited pro forma per share information for Abbott is based upon the number of
outstanding Abbott common shares adjusted to include the number of Abbott common
shares that would be issued in the merger based on the number of shares of ALZA
common stock outstanding on the dates reported. The diluted unaudited pro forma
per share information for Abbott is based upon net income, adjusted for interest
expense on convertible securities, net of tax, divided by the number of
outstanding Abbott common shares adjusted to include the dilutive effect of
Abbott stock options and the number of Abbott common shares that would be issued
in the merger, including the dilutive effect of ALZA stock options, warrants and
convertible securities.

    The unaudited equivalent pro forma per share information for ALZA is based
on the unaudited pro forma amounts per share for Abbott multiplied by the
exchange ratio of 1.2. The basic earnings (loss) per share information for ALZA
is calculated by dividing net income (loss) by the weighted average number of
shares of ALZA common stock outstanding for the period. The diluted earnings
(loss) per share information for ALZA is calculated by dividing net income
(loss), adjusted for interest expense on convertible securities, net of tax, by
the weighted average number of shares of ALZA common stock outstanding for the
period plus the dilutive effect of ALZA stock options, warrants and convertible
securities.

    The information set forth below is qualified in its entirety by reference
to, and should be read in conjunction with, the historical consolidated
financial information of Abbott and ALZA incorporated by reference in this proxy
statement/prospectus and the pro forma financial information included in this
proxy statement/ prospectus.

                                       4
<PAGE>

<TABLE>
<CAPTION>
                                                                SIX MONTHS         YEAR ENDED DECEMBER 31,
                                                              ENDED JUNE 30,     ----------------------------
                                                                   1999          1998      1997         1996
                                                              --------------     -----  -----------     -----
<S>                                                           <C>                <C>    <C>             <C>
ABBOTT:
Income per share from continuing operations:
  Basic:
    Historical..............................................      $0.86          $1.53  $   1.36        $1.20
    Pro forma...............................................       0.82(1)        1.49      1.10(2)      1.17
  Diluted:
    Historical..............................................      $0.85          $1.51  $   1.34        $1.19
    Pro forma...............................................       0.80(1)        1.46      1.08(2)      1.15
Book value per share:
    Historical..............................................      $4.23          $3.77  $   3.27        $3.11
    Pro forma...............................................       4.28           3.82      3.26         3.30
Cash dividends declared per share:
    Historical..............................................      $0.34          $0.60  $   0.54        $0.48
    Pro forma...............................................       0.34           0.60      0.54         0.48

ALZA:
Income (loss) per share from continuing operations:
  Basic:
    Historical..............................................      $0.38(3)       $1.09  $  (2.83)(4)    $0.86
    Equivalent pro forma....................................       0.99(1)        1.78      1.32(2)      1.41
  Diluted:
    Historical..............................................      $0.37(3)       $1.07  $  (2.83)(4)    $0.84
    Equivalent pro forma....................................       0.97(1)        1.75      1.30(2)      1.38
Book value per share:
    Historical..............................................      $5.90          $5.30  $   3.75        $6.95
    Equivalent pro forma....................................       5.14           4.58      3.91         3.96
Cash dividends declared per share:
    Historical..............................................         --             --     --              --
    Equivalent pro forma....................................      $0.41          $0.72  $   0.65        $0.58
</TABLE>

- ------------------------

(1) Includes a charge of $32.6 million related to ALZA's acquisition of SEQUUS
    Pharmaceuticals, Inc., less a tax benefit of $7.8 million. Before such
    charge, basic and diluted pro forma income per Abbott share from continuing
    operations would have been $0.84 and $0.82, respectively.

(2) Reflects a total of $368.7 million (or $0.22 per pro forma Abbott share,
    diluted) of charges, including a $247.0 million charge and $8.0 million of
    interest expense related to ALZA's distribution of shares of Crescendo
    Pharmaceuticals Corporation class A common stock, $108.5 million for
    acquired in-process research and development, an asset write-down of $11.5
    million and costs of $1.8 million related to a workforce reduction, less a
    tax benefit of $8.1 million. Before such charges, pro forma diluted income
    per Abbott share from continuing operations would have been $1.30.

(3) Includes a charge of $32.6 million related to ALZA's acquisition of SEQUUS,
    less a tax benefit of $7.8 million. Before such charge, historical basic and
    diluted income per ALZA share from continuing operations would have been
    $0.62 and $0.61, respectively.

(4) Reflects a total of $368.7 million (or $3.77 per historical ALZA share,
    diluted) of charges, including a $247.0 million charge and $8.0 million of
    interest expense related to ALZA's distribution of shares of Crescendo class
    A common stock, $108.5 million for acquired in-process research and
    development, an asset write-down of $11.5 million and costs of $1.8 million
    related to a workforce reduction, less a tax benefit of $8.1 million. Before
    such charges, historical basic and diluted earnings per ALZA share from
    continuing operations would have been $0.96 and $0.94, respectively.

                                       5
<PAGE>
THE MEETING

    The meeting of ALZA's stockholders will take place on Tuesday, September 21,
1999 at 1900 Charleston Road, Mountain View, California, at 9:00 a.m. Pacific
time. At the meeting, you will be asked to adopt the merger agreement and
approve the merger.

VOTE REQUIRED

    Each stockholder of record on the record date is entitled to one vote for
each share of ALZA common stock held on each matter submitted to a vote at the
meeting. A majority of the shares of ALZA common stock outstanding on the record
date represented in person, or by proxy, constitutes a quorum for consideration
of such matters at the meeting. If a quorum is present at the meeting, the
affirmative vote of at least a majority of the outstanding shares of ALZA common
stock is required to adopt the merger agreement and approve the merger.

THE MERGER AGREEMENT AND THE MERGER

    The merger agreement is attached as Annex A to this proxy
statement/prospectus. You should read the merger agreement because it, and not
this proxy statement/prospectus, is the legal document that governs the merger.

RECOMMENDATION TO ALZA'S STOCKHOLDERS

    ALZA's board of directors has determined that the merger agreement and the
merger are in the best interest of ALZA and its stockholders. Accordingly,
ALZA's board of directors has unanimously approved and declared advisable the
merger agreement, and recommends that you vote to adopt the merger agreement and
approve the merger at the meeting. See "The Merger Agreement and the
Merger--Background of the Merger" and "The Merger Agreement and the
Merger--Reasons for the Merger; Recommendations of ALZA's Board of Directors."

INTERESTS OF ALZA DIRECTORS AND OFFICERS IN THE MERGER THAT ARE DIFFERENT FROM
  YOUR INTERESTS

    Some of the members of ALZA's board of directors and some of ALZA's
executive officers have personal interests in the merger that are different from
yours.

    - All outstanding options to purchase ALZA common stock, including those
      held by officers and directors of ALZA, will fully vest at the effective
      time of the merger and will become options to purchase Abbott common
      shares, subject to adjustment to reflect the exchange ratio.

    - Restrictions on substantially all of the shares of restricted stock held
      by executive officers of ALZA will lapse at the effective time of the
      merger and the shares will be converted to Abbott common shares, subject
      to adjustment to reflect the exchange ratio.

    - The executive officers of ALZA will be entitled to severance payments and
      payments in connection with agreements not to compete with ALZA in the
      event of the termination of their employment following the merger.

    - Some current executive officers of ALZA will remain executive officers of
      ALZA after the merger.

    These interests are described under "The Merger Agreement and the
Merger--Interests of ALZA Directors and Officers in the Merger that are
Different from Your Interests."

    Each share of ALZA common stock held by ALZA's directors, executive officers
and their affiliates at the effective time of the merger will, upon completion
of the merger, along with all other ALZA common stock, be converted into the
right to receive 1.2 Abbott common shares.

    ALZA's board of directors was aware of these interests and considered them,
among other matters, when approving the merger.

    ALZA's directors, executive officers and their affiliates, including any
person who served as a director or executive officer of ALZA at

                                       6
<PAGE>
any time during 1998, beneficially owned, as of August 13, 1999, less than 1% of
ALZA's outstanding common stock.

    Abbott's directors, executive officers and their affiliates, including any
person who served as a director or executive officer of Abbott at any time
during 1998, did not beneficially own, as of August 13, 1999, any shares of
ALZA's common stock.

OPINIONS OF THE FINANCIAL ADVISORS TO ALZA'S BOARD OF DIRECTORS

    Chase Securities Inc. and Merrill Lynch & Co. delivered to ALZA's board of
directors their written opinions dated June 21, 1999 stating as of that date and
based upon the factors and assumptions described in their opinions that the
exchange ratio was fair from a financial point of view to holders of shares of
ALZA common stock. Their opinions are attached to this proxy
statement/prospectus as Annexes B and C. You should read them completely to
understand the assumptions made, matters considered and limitations of the
reviews made by Chase Securities and Merrill Lynch in providing their opinions.

WHAT WE NEED TO DO TO COMPLETE THE MERGER

    We will complete the merger only if the conditions set forth in the merger
agreement are satisfied or, in some cases, waived. These conditions include:

    - adoption of the merger agreement and approval of the merger by ALZA's
      stockholders;

    - absence of any injunction or legal restraint blocking the merger or
      government proceedings trying to block the merger;

    - receipt of letters from Abbott's independent public accountants and ALZA's
      independent auditors confirming the availability of pooling-of-interests
      accounting treatment for the merger;

    - receipt of legal opinions that the merger will be treated as a tax-free
      reorganization under the Internal Revenue Code;

    - absence of any change in either Abbott or ALZA or any of their
      subsidiaries which has had or may have a material adverse effect on
      Abbott's or ALZA's business taken as a whole; and

    - the expiration or termination of the waiting period applicable to the
      completion of the merger under the Hart-Scott-Rodino Act.

    At any time before the merger, to the extent legally allowed, the board of
directors of Abbott or ALZA may waive compliance with any of the conditions
contained in the merger agreement without the approval of Abbott shareholders or
ALZA stockholders. As of the date of this proxy statement/prospectus, neither
Abbott nor ALZA expects that any condition will be waived.

    The approval of the merger by Abbott's shareholders is not required, and
Abbott is not seeking the approval of the merger from its shareholders.

TERMINATION OF THE MERGER AGREEMENT

    Abbott and ALZA can agree to terminate the merger agreement at any time
without completing the merger, even if ALZA's stockholders have approved it.

    Also, either Abbott or ALZA can, without the consent of the other, terminate
the merger agreement if:

    - the merger is not completed by December 31, 1999 or, under some
      circumstances relating to obtaining governmental approvals of the merger,
      March 31, 2000, unless the failure to complete the merger is due to a
      violation of the merger agreement by the party that wants to terminate the
      merger agreement;

    - ALZA's stockholders do not adopt the merger agreement and do not approve
      the merger at the meeting;

    - a court or regulatory agency has prohibited the merger and no appeal is
      possible; or

                                       7
<PAGE>
    - the other party materially breaches the merger agreement, and cannot or
      does not correct the breach before December 31, 1999 or, under some
      circumstances relating to obtaining governmental approvals of the merger,
      March 31, 2000.

    In addition, ALZA can terminate the merger agreement before the meeting if
ALZA's board of directors receives and approves a superior proposal from another
party; provided that ALZA gives Abbott an opportunity to match or better the
other party's proposal.

    Finally, Abbott can terminate the merger agreement if ALZA's board of
directors:

    - withdraws, adversely modifies or changes its recommendation in favor of
      the merger agreement in response to an acquisition proposal from another
      party;

    - fails to reconfirm its recommendation of the merger agreement within 15
      days after a written request by Abbott to do so in response to an
      acquisition proposal from another party; or

    - approves or recommends a superior proposal from another party.

TERMINATION FEE

    ALZA must pay Abbott a fee of $210 million in cash if the merger agreement
is terminated under any of the following circumstances:

    - if all of the following occur:

      (1) another party makes an acquisition proposal;

      (2) ALZA's board of directors does not withdraw, adversely modify or
          change its recommendation in favor of the merger agreement with
          Abbott;

      (3) ALZA's stockholders do not adopt the merger agreement with Abbott and
          do not approve the merger at the meeting;

      (4) either Abbott or ALZA terminates the merger agreement with Abbott; and
      (5) within 12 months of the termination of the merger agreement with
          Abbott, ALZA enters into an agreement with any other party to accept
          an acquisition proposal or an acquisition of ALZA is completed; or

    - if all of the following occur:

      (1) another party makes an acquisition proposal;

      (2) ALZA's board of directors withdraws, adversely modifies or changes its
          recommendation in favor of the merger agreement with Abbott;

      (3) ALZA's stockholders do not adopt the merger agreement with Abbott and
          do not approve the merger at the meeting; and

      (4) either Abbott or ALZA terminates the merger agreement with Abbott; or

    - if ALZA terminates the merger agreement before the meeting because ALZA's
      board of directors receives and approves a superior proposal from another
      party; or

    - if Abbott terminates the merger agreement because:

      (1) ALZA's board of directors withdraws, adversely modifies or changes its
          recommendation in favor of the merger agreement with Abbott as a
          result of an acquisition proposal from another party;

      (2) ALZA's board of directors fails to reconfirm its recommendation in
          favor of the merger agreement with Abbott within 15 days after a
          written request by Abbott to do so in response to an acquisition
          proposal;

      (3) ALZA's board of directors recommends a superior proposal from another
          party; or

                                       8
<PAGE>
      (4) there has been a material breach by ALZA of its obligation not to
          solicit, encourage or engage in negotiations regarding an alternative
          acquisition proposal.

NON-SOLICITATION OF COMPETING PROPOSALS

    The merger agreement generally restricts ALZA's ability to initiate,
solicit, encourage or otherwise facilitate any competing merger or acquisition
inquiries, proposals or offers; however, ALZA may respond to unsolicited offers
as required by the fiduciary duties of ALZA's board of directors.

MODIFYING OR AMENDING THE MERGER AGREEMENT

    Abbott and ALZA can modify or amend the merger agreement, whether before or
after the meeting, if they both agree to do so. Each can waive its right to
require the other to comply with the merger agreement, where the law allows.

EXPENSES

    Abbott and ALZA will each pay its own expenses in connection with the merger
and the related transactions, except that Abbott and ALZA will evenly divide the
costs and expenses that they incur in printing and mailing this proxy
statement/prospectus, and certain regulatory fees.

CO-PROMOTION AGREEMENTS

    Abbott and ALZA entered into two co-promotion agreements that provide that
Abbott will assist ALZA in promoting Ditropan XL-Registered Trademark- in the
United States. Under one of the co-promotion agreements, co-promotion activities
began shortly after the signing of that co-promotion agreement and will continue
for an initial period of 90 days and are terminable by either party.
Co-promotion activities under the other agreement do not begin until 30 days
after the date, if applicable, that the merger agreement is terminated and will
continue until June 30, 2004. In addition, both co-promotion agreements provide
that ALZA must first offer to Abbott the right to co-promote and/or license
OROS-Registered Trademark- Methylphenidate in the United States before offering
that right to another party. See "The Merger Agreement and the Merger--
Co-Promotion Agreements."

                                       9
<PAGE>
SELECTED HISTORICAL FINANCIAL INFORMATION OF ABBOTT

    Abbott is providing the following information to aid you in your analysis of
the financial aspects of the merger. Abbott derived this information from
audited financial statements for 1994 through 1998 and unaudited financial
statements for the six months ended June 30, 1998 and 1999. In the opinion of
Abbott, this information reflects all adjustments, consisting only of normal
recurring adjustments, necessary for a fair presentation of the results of
operations and financial condition for the six months ended June 30, 1998 and
1999. Results for interim periods should not be considered indicative of results
for any other periods or for the year. This information is only a summary and
you should read it in conjunction with Abbott's historical financial statements
and related notes and the section titled "Financial Review" contained in
Abbott's annual reports, quarterly reports and other information on file with
the Securities and Exchange Commission and incorporated by reference in this
proxy statement/prospectus. See "Additional Information--Where You Can Find More
Information."

<TABLE>
<CAPTION>
                                                           ABBOTT LABORATORIES
                             -------------------------------------------------------------------------------
                               SIX MONTHS ENDED
                                   JUNE 30,                         YEAR ENDED DECEMBER 31,
                             --------------------  ---------------------------------------------------------
                               1999       1998        1998        1997        1996        1995       1994
                             ---------  ---------  ----------  ----------  ----------  ----------  ---------
                                                  (IN MILLIONS, EXCEPT PER SHARE DATA)
<S>                          <C>        <C>        <C>         <C>         <C>         <C>         <C>
HISTORICAL CONSOLIDATED
  STATEMENT OF OPERATIONS
  DATA:
Net sales..................  $ 6,542.2  $ 6,111.7  $ 12,477.8  $ 11,883.5  $ 11,013.5  $ 10,012.2  $ 9,156.0
Net earnings...............    1,309.2    1,175.2     2,333.2     2,094.5     1,882.0     1,688.7    1,516.7
Earnings per share--
  diluted..................  $    0.85  $    0.76  $     1.51  $     1.34  $     1.19  $     1.05  $    0.92
Weighted average shares and
  assumed
  conversions--diluted.....    1,541.8    1,547.6     1,545.7     1,561.5     1,580.6     1,607.3    1,639.8
</TABLE>

<TABLE>
<CAPTION>
                                                                           DECEMBER 31,
                                          JUNE 30,   --------------------------------------------------------
                                            1999        1998        1997        1996       1995       1994
                                         ----------  ----------  ----------  ----------  ---------  ---------
                                                                    (IN MILLIONS)
<S>                                      <C>         <C>         <C>         <C>         <C>        <C>
HISTORICAL CONSOLIDATED BALANCE SHEET
  DATA:
Working capital........................  $  1,376.8  $    591.0  $      3.7  $    137.2  $   436.4  $   400.5
Total assets...........................    13,145.1    13,216.2    12,061.1    11,125.6    9,412.6    8,523.7
Total long-term debt...................     1,337.6     1,339.7       938.0       932.9      435.2      287.1
Total shareholders' investment.........     6,439.3     5,713.7     4,998.7     4,820.2    4,396.8    4,049.4
</TABLE>

                                       10
<PAGE>
SELECTED HISTORICAL FINANCIAL INFORMATION OF ALZA

    ALZA is providing the following information to aid you in your analysis of
the financial aspects of the merger. ALZA derived this information from audited
financial statements for 1994 through 1998 and unaudited financial statements
for the six months ended June 30, 1998 and 1999. In the opinion of ALZA, this
information reflects all adjustments, consisting only of normal recurring
adjustments, necessary for a fair presentation of the results of operations and
financial condition for the six months ended June 30, 1998 and 1999. Results for
interim periods should not be considered indicative of results for any other
periods or for the year. This information is only a summary and you should read
it in conjunction with ALZA's historical financial statements and related notes
and "Management's Discussion and Analysis of Financial Condition and Results of
Operations" contained in ALZA's annual reports, quarterly reports and other
information on file with the Securities and Exchange Commission and incorporated
by reference in this proxy statement/prospectus. See "Additional
Information--Where You Can Find More Information."

<TABLE>
<CAPTION>
                                                             ALZA CORPORATION
                                     -----------------------------------------------------------------
                                     SIX MONTHS ENDED
                                         JUNE 30,                  YEAR ENDED DECEMBER 31,
                                     ----------------  -----------------------------------------------
                                      1999      1998    1998      1997           1996    1995    1994
                                     ------    ------  ------  -----------      ------  ------  ------
                                                   (IN MILLIONS, EXCEPT PER SHARE DATA)
<S>                                  <C>       <C>     <C>     <C>              <C>     <C>     <C>
HISTORICAL CONSOLIDATED STATEMENT
  OF OPERATIONS DATA:
Total revenues.....................  $380.7    $301.8  $646.9  $     504.4      $446.1  $326.6  $265.0
Net income (loss)..................    37.9(1)   55.9   108.3       (275.2)(2)    82.1    52.2    38.5
Earnings (loss) per
  share--diluted...................  $ 0.37(1) $ 0.56  $ 1.07  $     (2.83)(2)  $ 0.84  $ 0.56  $ 0.43
Weighted average shares and assumed
  conversions--diluted.............   102.9     100.7   101.5         97.3        97.4    93.3    90.3
</TABLE>

<TABLE>
<CAPTION>
                                                                                 DECEMBER 31,
                                                 JUNE 30,    -----------------------------------------------------
                                                   1999        1998       1997       1996       1995       1994
                                                -----------  ---------  ---------  ---------  ---------  ---------
                                                                          (IN MILLIONS)
<S>                                             <C>          <C>        <C>        <C>        <C>        <C>
HISTORICAL CONSOLIDATED BALANCE SHEET DATA:
Working capital...............................   $   328.0   $   297.1  $   276.9  $   533.4  $   319.0  $   215.3
Total assets..................................     1,729.9     1,666.6    1,450.7    1,698.6    1,018.0      834.1
Convertible debentures(3).....................       933.6       922.6      902.6      882.3      362.9      344.6
Total long-term debt..........................       973.4       966.1      932.2      893.2      363.0      345.5
Total stockholders' equity....................       597.1       531.9      366.3      670.9      527.2      385.0
</TABLE>

- ------------------------

(1) Includes a charge of $32.6 related to ALZA's acquisition of SEQUUS, less a
    tax benefit of $7.8. Net income and diluted earnings per share before such
    charge would have been $62.7 and $0.61, respectively.

(2) Reflects a total of $368.7 (or $3.77 per historical ALZA share, diluted) of
    charges, including a $247.0 charge and $8.0 of interest expense related to
    ALZA's distribution of shares of Crescendo class A common stock, $108.5 for
    acquired in-process research and development, an asset write-down of $11.5
    and costs of $1.8 related to a workforce reduction, less a tax benefit of
    $8.1. Before such charges, historical net income and earnings per share
    would have been $93.4 and $0.94, respectively.

(3) Included in total long-term debt.

                                       11
<PAGE>
PRO FORMA FINANCIAL INFORMATION OF ABBOTT

    The following describes the pro forma effect of the merger on (1) Abbott's
unaudited income statements for the six months ended June 30, 1998 and 1999 and
the years ended December 31, 1996, 1997 and 1998 and (2) its unaudited balance
sheet as of June 30, 1999 and December 31, 1996, 1997 and 1998, based on the
historical consolidated financial statements of Abbott and ALZA.

    The unaudited pro forma financial information and the accompanying notes
should be read in conjunction with the historical financial information and
related notes of Abbott and ALZA, incorporated by reference in this proxy
statement/prospectus.

    The unaudited pro forma consolidated financial information is provided for
informational purposes only and does not purport to represent what Abbott's
financial position and results of operations would actually have been had the
merger and other pro forma adjustments in fact occurred at the dates indicated.

    The unaudited pro forma consolidated statement of operations data and
consolidated balance sheet data of Abbott illustrate the estimated effects of
the merger as if that transaction had occurred at the beginning of the periods
presented and end of the periods presented, respectively.

    Management of Abbott and ALZA have concluded that this merger qualifies as a
pooling-of-interests business combination for accounting purposes. Under this
method of accounting, the recorded historical cost basis of the assets and
liabilities of Abbott and ALZA will be carried forward to the operations of the
combined company at their historical recorded amounts. Results of operations of
the combined company will include income of Abbott and ALZA for the entire
fiscal period in which the combination occurs, and the historical results of
operations of the separate companies for fiscal years prior to the merger will
be combined and reported as the results of operations of the combined company.
No adjustments have been made to the unaudited condensed pro forma financial
statement data of Abbott and ALZA to conform the accounting policies of the
combined company as the nature and amounts of such adjustments are not expected
to be significant.

    Some of the conditions to be met for pooling-of-interests accounting cannot
be fully assessed until the passage of specified periods of time after the
effective time of the merger, as certain of the conditions for
pooling-of-interests accounting address transactions occurring within these
specified periods of time. Certain events, including certain transactions in
Abbott common shares or ALZA common stock by affiliates of Abbott and ALZA,
respectively, could prevent the merger from qualifying as a pooling-of-interests
for accounting purposes.

    Because ALZA is not considered a "significant subsidiary" of Abbott for
purposes of the Securities and Exchange Commission's accounting rules, unaudited
pro forma combined financial statements that give effect to the merger using the
pooling-of-interests accounting method are not presented in this proxy
statement/prospectus.

                                       12
<PAGE>

<TABLE>
<CAPTION>
                                                                    ABBOTT LABORATORIES
                                                  --------------------------------------------------------
                                                    SIX MONTHS ENDED
                                                        JUNE 30,             YEAR ENDED DECEMBER 31,
                                                  --------------------  ----------------------------------
                                                    1999       1998        1998        1997        1996
                                                  ---------  ---------  ----------  ----------  ----------
                                                            (IN MILLIONS, EXCEPT PER SHARE DATA)
<S>                                               <C>        <C>        <C>         <C>         <C>
PRO FORMA CONSOLIDATED STATEMENT OF OPERATIONS
  DATA:
Net sales.......................................  $ 6,922.9  $ 6,413.5  $ 13,124.7  $ 12,387.9  $ 11,459.6
Net earnings....................................    1,347.1(1)   1,231.1    2,441.5    1,819.3(2)    1,964.1
Earnings per share--diluted.....................       0.80(1)      0.73       1.46       1.08(2)       1.15
Weighted average shares and assumed
  conversions--diluted..........................    1,695.3    1,701.4     1,697.6     1,711.1     1,728.0
</TABLE>

<TABLE>
<CAPTION>
                                                                                       DECEMBER 31,
                                                                 JUNE 30,   ----------------------------------
                                                                   1999        1998        1997        1996
                                                                ----------  ----------  ----------  ----------
                                                                                (IN MILLIONS)
<S>                                                             <C>         <C>         <C>         <C>
PRO FORMA CONSOLIDATED BALANCE SHEET DATA:
Working capital...............................................  $  1,704.8  $    888.1  $    280.6  $    670.6
Total assets..................................................    14,875.0    14,882.8    13,511.8    12,824.2
Total long-term debt..........................................     2,311.0     2,305.8     1,870.2     1,826.1
Total shareholders' investment................................     7,036.4     6,245.6     5,365.0     5,491.1
</TABLE>

- ------------------------

(1) Includes a charge of $32.6 related to ALZA's acquisition of SEQUUS, less a
    tax benefit of $7.8. Net earnings and diluted earnings per share before such
    charge would have been $1,371.9 and $0.82, respectively.

(2) Reflects a total of $368.7 (or $0.22 per pro forma Abbott share, diluted) of
    charges, including a $247.0 charge and $8.0 of interest expense related to
    ALZA's distribution of shares of Crescendo class A common stock, $108.5 for
    acquired in-process research and development, an asset write-down by ALZA of
    $11.5 and costs of $1.8 related to an ALZA workforce reduction, less a tax
    benefit of $8.1. Before such charges, diluted pro forma net earnings and
    diluted pro forma earnings per share would have been $2,188.0 and $1.30,
    respectively.

                                       13
<PAGE>
                                  RISK FACTORS

    IN ADDITION TO THE OTHER INFORMATION INCLUDED IN THIS PROXY
STATEMENT/PROSPECTUS, YOU SHOULD CAREFULLY CONSIDER THE FOLLOWING RISK FACTORS
IN DETERMINING WHETHER TO VOTE TO ADOPT THE MERGER AGREEMENT AND APPROVE THE
MERGER. THESE MATTERS SHOULD BE CONSIDERED IN ADDITION TO THE OTHER INFORMATION
INCLUDED OR INCORPORATED BY REFERENCE IN THIS PROXY STATEMENT/PROSPECTUS.

YOU WILL RECEIVE 1.2 ABBOTT COMMON SHARES DESPITE CHANGES IN MARKET VALUE OF
  ABBOTT COMMON SHARES OR ALZA COMMON STOCK.

    Upon completion of the merger, each share of ALZA common stock will be
exchanged for 1.2 Abbott common shares. Although this exchange ratio reflected a
premium to be paid to holders of ALZA common stock as of June 21, 1999, the
business day that Abbott and ALZA announced the terms of the merger, the market
value of a share of ALZA common stock could be equal to or greater than the
market value of 1.2 Abbott common shares at the effective time of the merger.
The exchange ratio will not be adjusted for changes in the market price of
either ALZA common stock or Abbott common shares.

FAILURE TO QUALIFY FOR POOLING-OF-INTERESTS ACCOUNTING TREATMENT MAY IMPACT
  REPORTED OPERATING RESULTS.

    If, after completion of the merger, the merger no longer qualifies for
pooling-of-interests accounting treatment, the purchase method of accounting
will apply. Under that method, the estimated fair value of Abbott common shares
issued in the merger would be recorded as the cost of acquiring the business of
ALZA. That cost would be allocated to the individual assets acquired and
liabilities assumed according to their respective fair values, with the excess
of the estimated fair value of Abbott common shares over the fair value of net
assets acquired recorded as goodwill, to be amortized over a period of from 10
to 20 years.

    Purchase accounting treatment would have a material adverse effect on the
reported operating results of Abbott as compared to pooling-of-interests
accounting treatment because of required charges to Abbott's earnings for
in-process research and development and amortization of goodwill required by the
purchase accounting treatment.

THE INTEGRATION OF ALZA INTO ABBOTT MAY BE DIFFICULT AND EXPENSIVE TO ACHIEVE.

    The merger will present challenges to management, including the integration
of the operations, technologies and personnel of Abbott and ALZA, and special
risks, including possible unanticipated liabilities, unanticipated costs and
diversion of management attention.

    Abbott may not be able to successfully integrate or profitably manage ALZA's
businesses. In addition, following the merger, ALZA's businesses may not achieve
sales levels, profitability or cost savings that justify the investment made and
the acquisition may not be accretive to earnings in any future periods.

BECAUSE ABBOTT CONDUCTS A GREATER AMOUNT OF BUSINESS IN MORE FOREIGN COUNTRIES
  THAN ALZA, ABBOTT'S INTERNATIONAL OPERATIONS ARE SUBJECT TO MORE FOREIGN
  REGULATION AND GREATER ECONOMIC RISK.

    Abbott derives a greater percentage of its total revenue from foreign
operations as compared to ALZA. Abbott also conducts operations in more foreign
countries than ALZA. As a result, Abbott's financial condition and results of
operations are more likely to be affected adversely by foreign regulation and
economic risks, including:

    - price and currency exchange controls;

    - changes in currency exchange rates;

    - limitations on foreign participation in local enterprises; and

    - expropriation, nationalization and other governmental action.

                                       14
<PAGE>
ALZA'S CLIENT BUSINESS COULD BE ADVERSELY AFFECTED BY THE MERGER.

    A significant portion of ALZA's business involves developing products
incorporating ALZA's drug delivery technologies for commercialization by
pharmaceutical company clients. It is possible that after the merger
pharmaceutical companies may be less likely to enter into such relationships, or
may terminate existing relationships, with the combined company for competitive
reasons due to its size and the scope of its commercial operations, and as a
result, client business could be impaired.

EXPENSES RESULTING FROM THE MERGER WILL BE SUBSTANTIAL AND MAY AFFECT ABBOTT'S
  RESULTS OF OPERATIONS.

    Abbott and ALZA estimate they will incur combined aggregate direct
transaction costs of approximately $45 million associated with the merger,
consisting of transaction fees for investment bankers, attorneys, accountants
and other related costs. These one-time transaction costs will be charged to
operations upon completion of the merger. It is expected that following the
merger, the combined company will incur additional one-time expenses, currently
estimated to be approximately $55 million. There can be no assurance that the
combined company will not incur additional charges to reflect costs associated
with the merger.

                                 THE COMPANIES

ABBOTT LABORATORIES

    Abbott Laboratories is an Illinois corporation incorporated in 1900.
Abbott's principal business is the discovery, development, manufacture and sale
of a broad and diversified line of health care products and services.

    Abbott has six revenue segments:

       (1) Pharmaceutical Products--includes a broad line of adult and pediatric
           pharmaceuticals which are sold primarily on the prescription or
           recommendation of physicians.

       (2) Diagnostic Products--includes diagnostic systems and tests for blood
           banks, hospitals, commercial laboratories, alternate-care testing
           sites and consumers.

       (3) Hospital Products--includes drugs and drug delivery systems,
           perioperative and intensive care products, cardiovascular products,
           renal products, oncology products, intravenous and irrigation
           solutions, related manual and electronic administration equipment and
           diagnostic imaging products for hospitals and alternate-care sites.

       (4) Ross Products--includes a broad line of adult and pediatric
           nutritionals. These products are sold primarily on the recommendation
           of physicians or other health care professionals. The segment also
           includes specialty pharmaceuticals and consumer products.

       (5) International--includes a broad line of hospital, pharmaceutical and
           adult and pediatric nutritional products marketed and primarily
           manufactured outside the United States. These products are sold
           primarily on the prescription or recommendation of physicians and
           other health care professionals. This segment also includes consumer
           products.

       (6) Chemical and Agricultural Products--includes agricultural and
           chemical products, bulk pharmaceuticals and animal health products.

    Abbott also has a 50 percent owned joint venture, TAP Holdings Inc. TAP and
its subsidiary develop and market pharmaceutical products in the United States.
TAP's products are generally sold directly to physicians, retailers,
wholesalers, health care facilities and government agencies.

    Abbott purchases, in the ordinary course of business, necessary raw
materials and supplies essential to its operations from numerous suppliers
worldwide. Abbott markets products in approximately 130 countries through
affiliates and distributors. Most of Abbott's products are sold both in the
United States and internationally. Abbott employs approximately 56,000 persons
in its various offices, plants and facilities located throughout North America,
South America, Europe, Africa, Asia and Australia.

                                       15
<PAGE>
    Additional information concerning Abbott and its subsidiaries is included in
the Abbott documents filed with the Securities and Exchange Commission and
incorporated in this proxy statement/prospectus by reference. See "Additional
Information--Where You Can Find More Information."

ACQUISITION OF PERCLOSE INC.

    On July 8, 1999, Abbott announced that it had signed a definitive agreement
to acquire Perclose, Inc., a leading arterial closure device manufacturer, for
approximately $680 million in Abbott common shares. For the year ended March 31,
1999, Perclose reported net revenue of approximately $43.3 million and net
income of approximately $5.5 million. The transaction is designed to provide
Perclose stockholders with Abbott common shares with a market value of $54.00
for each share of Perclose common stock. The closing of the transaction is
subject to a number of conditions, including regulatory approval and the
approval of Perclose's stockholders. The transaction is intended to receive
pooling-of-interests accounting treatment and is expected be completed by the
end of 1999. The transaction may not, however, be completed by that time.

ALZA CORPORATION

    ALZA is a research-based pharmaceutical company with leading drug delivery
technologies. ALZA applies its technologies to develop pharmaceutical products
with enhanced therapeutic value for its own portfolio and for many of the
world's leading pharmaceutical companies. ALZA's sales and marketing efforts are
currently focused on the urology and oncology fields of medicine.

    Until approximately 1993, ALZA's business consisted almost exclusively of
product development activities undertaken pursuant to joint development and
commercialization agreements with large pharmaceutical companies. Among the
ALZA-developed products commercialized to date by client companies under these
arrangements are Procardia XL-Registered Trademark-/Adalat
CR-Registered Trademark- (nifedipine) for the treatment of angina and
hypertension, Transderm-Nitro-Registered Trademark- (nitroglycerin transdermal
system) for the prevention and treatment of angina,
Duragesic-Registered Trademark- (fentanyl transdermal system) for treatment of
certain patients with chronic pain, NicoDerm-Registered Trademark-
CQ-Registered Trademark- (nicotine transdermal system) for use as an aid in
smoking cessation, and Glucotrol XL-Registered Trademark- (glipizide) for the
treatment of Type II diabetes.

    Beginning in 1993, ALZA embarked on a new strategy to become a
fully-integrated commercial pharmaceutical company. Although ALZA has continued
its traditional product development arrangements with client companies, and
currently has products in development with a number of major pharmaceutical
companies, ALZA has expanded its commercialization capabilities and activities,
with significant expansion in 1997 and 1998. ALZA Pharmaceuticals now markets
and promotes 15 urology and oncology products. At December 31, 1998, ALZA
Pharmaceuticals had a specialty United States oncology sales organization of
approximately 75 sales professionals, and a sales organization of over 300
United States sales professionals, plus 12 in Canada, promoting its urology
products to urologists and other specialists, as well as primary care
physicians. In addition, ALZA's Ditropan-Registered Trademark- XL (oxybutynin
chloride) product, launched in the United States on February 1, 1999, is
co-promoted to general practitioners by approximately 350 sales professionals
from UCB Pharma, Inc. and by approximately 300 sales professionals from Abbott.

                                       16
<PAGE>
    Additional information concerning ALZA and its subsidiaries is included in
the ALZA documents filed with the Securities and Exchange Commission and
incorporated in this proxy statement/prospectus by reference. See "Additional
Information--Where You Can Find More Information."

ACQUISITION OF SEQUUS PHARMACEUTICALS, INC.

    On March 16, 1999, ALZA completed its merger with SEQUUS Pharmaceuticals,
Inc., an integrated pharmaceutical company engaged in the development of
therapies for cancer and other diseases utilizing advanced drug delivery
technologies. This transaction was accounted for under the pooling-of-interests
method of accounting. All historical information related to ALZA reported in, or
incorporated by reference into, this proxy statement/prospectus includes the
results of SEQUUS for all periods presented.

                                  THE MEETING

PURPOSE OF THE MEETING

    At the meeting, you will be asked to consider and vote upon:

       - a proposal to adopt the merger agreement and approve the merger; and

       - such other business related to matters incidental to the approval of
         the merger as may properly be brought before the meeting.

    ALZA's board of directors is not aware, as of the date of this proxy
statement/prospectus, of any other matters that may properly come before the
meeting. If any such other matters properly come before the meeting, or at a
subsequent meeting following any adjournment or postponement of the meeting, the
persons named in ALZA's proxy intend to vote proxies in accordance with their
discretion on any such matters and, unless other instructions are given, ALZA's
proxy will give such persons the power to do so.

    ALZA's board of directors carefully reviewed and considered the terms and
conditions of the merger and concluded that the merger is in the best interests
of ALZA and its stockholders. Accordingly, by a unanimous vote, ALZA's board of
directors has approved the merger and determined its advisability, and
recommends that you vote to adopt the merger agreement and approve the merger.

DATE, TIME AND PLACE; RECORD DATE

    The meeting of ALZA's stockholders will take place on Tuesday, September 21,
1999 at 9:00 a.m. Pacific time, at 1900 Charleston Road, Mountain View,
California. The record date to determine who is entitled to vote at the meeting
is Monday, August 16, 1999. Only holders of record of ALZA common stock at the
close of business on the record date will be entitled to notice of, and to vote
at, the meeting. A complete list of stockholders as of the record date will be
available for inspection at ALZA's offices in Palo Alto, California, during
normal business hours upon written demand by you or your agent or attorney
beginning two business days after the date of this notice and continuing through
the meeting. You or your agent or attorney may, upon written notice and subject
to Section 220 of the Delaware General Corporation Law, copy the list of
stockholders during regular business hours during the inspection period at your
expense. If your ALZA common stock is registered in the name of a brokerage firm
or trustee and you plan to attend the meeting, you must obtain from the firm or
trustee a letter, account statement or other evidence of your beneficial
ownership of those shares of ALZA common stock in order to be admitted to the
meeting. As of August 11, 1999, a total of 101,686,193 shares of ALZA common
stock were issued and outstanding.

                                       17
<PAGE>
    The meeting may be adjourned or postponed to another date or place for
proper purposes, including, without limitation, for the purpose of soliciting
additional proxies. Unless revoked, proxies will remain valid following such
adjournment or postponement.

YOUR VOTING RIGHTS

    Each stockholder of record on the record date is entitled to one vote for
each share of ALZA common stock held on each matter submitted to a vote at the
meeting. A majority of the outstanding shares of ALZA common stock represented
in person, or by proxy, constitutes a quorum for consideration of such matters
at the meeting. If a quorum is present at the meeting, the affirmative vote of
at least a majority of the outstanding shares of ALZA common stock is required
to adopt the merger agreement and approve the merger. Abstentions will,
therefore, have the effect of votes against the merger.

GIVING AND REVOKING YOUR PROXY; COSTS OF SOLICITATION

    Any holder of shares of ALZA common stock may vote such stockholder's shares
either in person or by duly authorized proxy. The giving of a proxy by an ALZA
stockholder will not affect the stockholder's right to vote such shares if the
stockholder attends the meeting and desires to vote in person. Prior to the
voting of a proxy, the proxy may be revoked by the stockholder by delivering
written notice of revocation to the Secretary of ALZA, by executing a
subsequently dated proxy or by voting in person at the meeting. Attendance at
the meeting will not by itself constitute revocation of a proxy. All shares
represented by effective proxies on the enclosed form of proxy received by ALZA
will be voted at the meeting in accordance with the terms of the proxies. If no
instructions are given, the proxies will be voted FOR the adoption of the merger
agreement and the approval of the merger.

    In addition to soliciting proxies by mail, officers, directors and employees
of ALZA, without receiving any additional compensation, may solicit proxies by
telephone, fax, in person or by other means. Arrangements will also be made with
brokerage firms and other custodians, nominees and fiduciaries to forward proxy
solicitation materials to the beneficial owners of ALZA common stock held of
record by those persons, and ALZA will reimburse the brokerage firms,
custodians, nominees and fiduciaries for reasonable out-of-pocket expenses
incurred by them in connection therewith. ALZA has retained Corporate Investor
Communications, Inc. to assist in the solicitation of proxies at an estimated
cost of $15,000.

NO APPRAISAL RIGHTS

    Under Delaware law, holders of ALZA common stock are not entitled to
dissenters' or appraisal rights in connection with the merger.

                      THE MERGER AGREEMENT AND THE MERGER

    THE FOLLOWING IS A SUMMARY OF THE MATERIAL TERMS OF THE MERGER AGREEMENT AND
IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO THE MERGER AGREEMENT. A COPY OF THE
MERGER AGREEMENT IS ATTACHED AS ANNEX A TO THIS PROXY STATEMENT/PROSPECTUS AND
IS INCORPORATED IN THIS PROXY STATEMENT/PROSPECTUS BY REFERENCE. YOU SHOULD READ
THE MERGER AGREEMENT BECAUSE IT, AND NOT THIS PROXY STATEMENT/PROSPECTUS, IS THE
LEGAL DOCUMENT THAT GOVERNS THE MERGER.

GENERAL DESCRIPTION OF THE MERGER

    The merger agreement provides that, at the effective time of the merger, AC
Merger Sub Inc., a wholly owned subsidiary of Abbott, will merge with and into
ALZA, with ALZA continuing in existence as the surviving corporation. Each share
of ALZA common stock issued and outstanding at the effective time of the merger,
other than shares owned by Abbott, ALZA or any direct or indirect

                                       18
<PAGE>
subsidiary of Abbott or ALZA, which will be canceled in the merger, will be
converted into 1.2 Abbott common shares. Upon completion of the merger, ALZA
will be a wholly owned subsidiary of Abbott and market trading of ALZA common
stock will cease.

BACKGROUND OF THE MERGER

    On May 12, 1999, Mr. Miles White, Abbott's Chief Executive Officer, called
Dr. Ernest Mario, ALZA's Chief Executive Officer, proposing that the two of
them, together with Mr. Arthur Higgins, Senior Vice President, Pharmaceutical
Operations of Abbott, meet. Mr. White indicated that he would like to explore
the possibility of a business combination at the meeting. A meeting was
scheduled for May 20, 1999.

    On May 20, 1999, Dr. Mario met with Mr. White and Mr. Higgins. At the
meeting, they discussed the possibility of a business combination between Abbott
and ALZA and whether a business combination would provide strategic and
financial value to the stockholders of each company.

    On May 21, 1999, ALZA's board of directors held a telephone meeting during
which Dr. Mario briefed ALZA's board of directors on his meeting with Mr. White
and Mr. Higgins. Dr. Mario provided the directors with an overview of Abbott's
business and operations and a preliminary review of possible benefits that could
result from a business combination. A representative of Chase Securities and
members of senior management of ALZA participated in the meeting. ALZA's board
of directors authorized ALZA's management to pursue further discussions
regarding a business combination with Abbott and to engage legal and financial
advisors to assist ALZA with the potential business combination.

    Thereafter, ALZA's senior management retained Chase Securities and Merrill
Lynch to provide financial advisory services to ALZA regarding the proposed
business combination with Abbott. ALZA's senior management also engaged Heller
Ehrman White & McAuliffe and Skadden Arps Slate Meagher & Flom LLP as co-counsel
to represent ALZA in the proposed business combination.

    On May 24, 1999, ALZA and Abbott entered into mutual confidentiality and
standstill agreements, which also provided for a 45-day period of exclusive
negotiations between ALZA and Abbott, subject to either party's right to
terminate such exclusivity period on seven days notice after June 8, 1999.

    On May 27, 1999, senior management of ALZA and Abbott each began due
diligence reviews of the other's business.

    On June 5 and 6, 1999, Dr. Mario and Mr. White held telephone discussions to
further review matters relating to the proposed business combination, including
additional information requirements.

    On June 11, 1999, Abbott held a regularly scheduled meeting of its board of
directors at which Abbott's senior management reviewed the possibility of a
business combination with ALZA, and Abbott's board of directors authorized
Abbott's senior management to continue to pursue a possible business combination
with ALZA.

    On June 12, 1999, Dr. Mario and Mr. White again held telephone discussions
regarding the proposed business combination, including possible financial terms
of the proposed business combination.

    On June 14, 1999, Abbott and its advisors and ALZA and its advisors
continued due diligence reviews of one another's business. Also on June 14,
1999, a draft of the merger agreement was circulated to senior management and
the advisors of each company who reviewed and negotiated the exchange ratio and
other terms of the merger agreement on June 15 through June 19, 1999. During
this period, they also negotiated the terms of two co-promotion agreements
between Abbott and ALZA.

                                       19
<PAGE>
    At a meeting of ALZA's board of directors held on June 19, 1999, ALZA's
senior management made presentations regarding the proposed business combination
and the status of the negotiations and discussions about the merger agreement
and the other arrangements. At the same meeting Chase Securities, Merrill Lynch,
Skadden Arps, Heller Ehrman and ALZA's independent auditors, Ernst & Young, made
presentations to ALZA's board of directors regarding the proposed business
combination. After discussion, ALZA's board of directors directed ALZA's senior
management and ALZA's advisors to continue the negotiations with Abbott. Further
negotiations occurred on June 19, 20 and 21, 1999.

    At a telephonic meeting of ALZA's board of directors held on June 21, 1999,
ALZA's senior management made further presentations regarding the proposed
business combination and the status of the negotiations and discussions about
the merger agreement and the other arrangements. At that meeting Chase
Securities and Merrill Lynch delivered their respective opinions to ALZA's board
of directors that the exchange ratio was fair, from a financial point of view,
to ALZA's stockholders. After further review and discussion, ALZA's board of
directors unanimously approved the merger agreement and determined its
advisability, approved the other arrangements and authorized senior management
of ALZA to execute and deliver to Abbott the merger agreement and the
co-promotion agreements. Simultaneously, Abbott's board of directors held a
telephonic meeting at which Abbott's board of directors considered the merger
and authorized the execution and delivery of the merger agreement and the
co-promotion agreements.

    The definitive merger agreement was executed on behalf of ALZA, Abbott and
AC Merger Sub on June 21, 1999 and the parties issued a joint press release
announcing the merger agreement.

MERGER-RELATED LITIGATION

    On June 22, 1999, a purported class action lawsuit was filed in the Superior
Court of the State of California, County of Santa Clara, against ALZA and all of
the current members of its Board of Directors. The action is captioned LISA
FRUCHTER V. ALZA CORPORATION, ET AL., No. CV 782725 (Santa Clara County,
California, Superior Court). The complaint alleges that ALZA and its directors
breached fiduciary duties owed to ALZA's stockholders when they permitted ALZA
to enter into the merger agreement with Abbott. In general, the complaint
alleges that the exchange ratio of 1.2 is inadequate and further alleges that
ALZA's board of directors had an obligation to place ALZA up for auction when it
entered into the merger agreement. The allegations purport to be based on
California law. The action seeks both an injunction to prevent the merger and
damages in the event that the merger is completed. ALZA believes the complaint
to be without merit and intends to defend the action vigorously. This action,
however, may not be finally resolved, or resolved on terms favorable to Abbott
and ALZA, before the merger is completed or at all.

REASONS FOR THE MERGER; RECOMMENDATION OF ALZA'S BOARD OF DIRECTORS

ALZA'S REASONS FOR THE MERGER

    In the course of reaching its decision to approve the merger agreement,
ALZA's board of directors considered and reviewed with ALZA's senior management
and outside advisors a number of factors relevant to the merger, including the
strategic overview and business plans of ALZA, its financial position, its
products and research and development portfolio, and its commercial operations.
ALZA's board of directors also considered, among other matters:

    - ALZA's board of directors' view that Abbott will provide greater levels of
      capital and other resources, including access to drugs in Abbott's
      development pipeline, to pursue research and product development programs
      and to expand ALZA's leadership role in drug delivery technologies;

    - ALZA's board of directors' view that Abbott's strengths in world-wide
      product registration, marketing and distribution will complement ALZA's
      strengths in developing products using

                                       20
<PAGE>
      advanced drug delivery technologies and in manufacturing such products,
      which should allow the combined company to more effectively develop,
      market and distribute new products on a worldwide basis;

    - ALZA's board of directors' view that Abbott's marketing strength in the
      medical fields of urology, neuroscience and pediatrics, and its commitment
      to developing an oncology franchise, complement ALZA's areas of
      therapeutic focus, and that the combined entity would provide a larger and
      more effective marketing organization with a more comprehensive portfolio
      of products in these medical fields than ALZA would have as a stand-alone
      company;

    - ALZA's board of directors' view that as a result of the merger, ALZA's
      stockholders will hold interests in a more diversified entity, with
      business and revenues not only from a broad-based pharmaceutical products
      business, but also from nutritional, diagnostic and hospital products
      businesses;

    - ALZA's board of directors' assessment of ALZA's strategic alternatives and
      its view that the merger was more attractive than remaining an independent
      company or attempting to increase ALZA's business by acquiring other
      companies;

    - information regarding historical market prices and other information with
      respect to ALZA common stock, and the financial performance and condition,
      assets, liabilities, business operations and prospects of each of Abbott
      and ALZA and their projected future values and prospects as separate
      entities and on a combined basis;

    - the presentations delivered by Chase Securities and Merrill Lynch, and the
      written fairness opinions of Chase Securities and Merrill Lynch, to the
      effect that as of the day of the opinions and based on and subject to the
      matters set forth in their respective fairness opinions, the exchange
      ratio was fair, from a financial point of view, to ALZA's stockholders;

    - the consideration to be received by ALZA's stockholders in the merger and
      the fact that the market value of Abbott common shares to be issued in
      exchange for each share of ALZA stock common stock represented a
      substantial premium over historical per share prices of ALZA common stock;

    - a comparison of selected recent acquisition and merger transactions in the
      industry as well as the trading performance for comparable companies in
      the industry;

    - ALZA's board of directors' belief that the terms of the merger agreement,
      including the parties' mutual representations, warranties and covenants,
      are reasonable;

    - the expected tax and accounting treatment of the merger; and

    - reports from ALZA's management and advisors as to the results of their
      review of Abbott's business.

    ALZA's board of directors also considered a number of potentially negative
factors in its deliberations concerning the merger, including, but not limited
to:

    - the risk that the benefits sought to be achieved in the merger will not be
      achieved;

    - the fixed nature of the exchange ratio and the resulting risk that, should
      there be a decrease in the market value of Abbott common shares, the value
      of the consideration to be received by ALZA's stockholders in the merger
      would be reduced;

    - the risks inherent in Abbott's broad-based health care products business,
      including risks associated with potential changes in the health care
      industry generally; and

    - the other risks described under "Risk Factors" in this proxy
      statement/prospectus.

    This summary is not meant to be an exhaustive description of the information
and factors considered by ALZA's board of directors but is believed to include
all material factors considered. In view of the wide variety of factors
considered by ALZA's board of directors it was not possible to

                                       21
<PAGE>
quantify or to give relative weights to the various factors. After taking into
consideration all of the factors set forth above, and other factors not set
forth, ALZA's board of directors unanimously approved the merger and the merger
agreement because of ALZA's board of directors' belief that the merger is fair
to, and in the best interests of, ALZA and its stockholders.

ABBOTT'S REASONS FOR THE MERGER

    Abbott believes that the combined corporation and its shareholders can
benefit from the merger because the proposed merger brings to Abbott:

    - a portfolio of existing pharmaceutical products that Abbott's larger
      global sales organization can distribute, increasing Abbott's sales and
      profits;

    - new products that ALZA is developing that Abbott can distribute in the
      future;

    - additional scientific expertise in drug delivery techniques and methods;
      and

    - strong technology relationships with pharmaceutical industry partners.

RECOMMENDATION OF ALZA'S BOARD OF DIRECTORS

    AFTER CAREFUL CONSIDERATION, YOUR BOARD OF DIRECTORS HAS UNANIMOUSLY
APPROVED AND DECLARED ADVISABLE THE MERGER AGREEMENT, AND RECOMMENDS THAT YOU
VOTE TO ADOPT THE MERGER AGREEMENT AND APPROVE THE MERGER AT THE MEETING.

    In considering the recommendation of ALZA's board of directors with respect
to the merger agreement and the merger, you should be aware that certain
directors and officers of ALZA have certain interests in the merger that are
different from, or are in addition to, the interests of ALZA stockholders
generally. Please see the section entitled "The Merger Agreement and the
Merger-- Interests of ALZA Directors and Officers in the Merger that are
Different from Your Interests" of this proxy statement/prospectus.

OPINION OF CHASE SECURITIES INC. TO ALZA'S BOARD OF DIRECTORS

    On June 21, 1999, Chase Securities delivered its written opinion to ALZA's
board of directors to the effect that, as of that date, and based upon the
assumptions made, matters considered and limits of review set forth in its
opinion, the exchange ratio was fair to the holders of ALZA's common stock from
a financial point of view.

    A COPY OF CHASE SECURITIES' OPINION, WHICH SETS FORTH THE ASSUMPTIONS MADE,
MATTERS CONSIDERED AND CERTAIN LIMITATIONS ON THE SCOPE OF REVIEW UNDERTAKEN BY
CHASE SECURITIES IS ATTACHED AS ANNEX B TO THIS PROXY STATEMENT/PROSPECTUS.
ALZA'S STOCKHOLDERS ARE URGED TO READ THE OPINION IN ITS ENTIRETY. CHASE
SECURITIES' OPINION WAS PROVIDED FOR THE USE AND BENEFIT OF ALZA'S BOARD OF
DIRECTORS IN ITS EVALUATION OF THE MERGER, WAS DIRECTED ONLY TO THE FAIRNESS TO
THE HOLDERS OF ALZA'S COMMON STOCK OF THE EXCHANGE RATIO FROM A FINANCIAL POINT
OF VIEW, AND DOES NOT CONSTITUTE A RECOMMENDATION TO ANY ALZA STOCKHOLDER AS TO
HOW SUCH STOCKHOLDER SHOULD VOTE WITH RESPECT TO THE MERGER. THE SUMMARY OF
CHASE SECURITIES' OPINION SET FORTH IN THIS PROXY STATEMENT/PROSPECTUS IS
QUALIFIED IN ITS ENTIRETY BY REFERENCE TO THE FULL TEXT OF ITS OPINION ATTACHED
AS ANNEX B TO THIS PROXY STATEMENT/PROSPECTUS.

    In arriving at its opinion, Chase Securities, among other things:

       - reviewed the merger agreement;

       - reviewed certain publicly available business and financial information
         that Chase Securities deemed relevant relating to ALZA and Abbott and
         the industries in which they operate;

       - reviewed certain internal non-public financial and operating data and
         forecasts provided to Chase Securities by the management of ALZA
         relating to the business of ALZA;

       - discussed with members of the senior managements of ALZA and Abbott,
         ALZA's and Abbott's operations, historical financial statements and
         future prospects, before and after

                                       22
<PAGE>
         giving effect to the merger (and, in the case of the future prospects
         of Abbott, Chase Securities was informed by Abbott to rely on public
         analysts' estimates as the most reasonable estimates for the purposes
         of its opinion);

       - compared the financial and operating performance of ALZA and Abbott
         with publicly available information concerning certain other companies
         Chase Securities deemed comparable and reviewed the relevant historical
         stock prices and trading volumes of ALZA common stock and Abbott common
         shares and certain publicly traded securities of such other companies;

       - reviewed the financial terms of certain recent business combinations
         and acquisition transactions Chase Securities deemed reasonably
         comparable to the merger and otherwise relevant to Chase Securities'
         inquiry; and

       - made such other analyses and examinations as Chase Securities deemed
         necessary or appropriate.

    Other than as set forth in the fourth bullet point above, in connection with
the preparation of Chase Securities' opinion, Chase Securities neither received
nor reviewed any non-public information prepared by or relating to Abbott. Chase
Securities assumed and relied upon, without assuming any responsibility for
verification, the accuracy and completeness of all of the financial and other
information provided to, discussed with or reviewed by or for Chase Securities,
or publicly available, for purposes of its opinion and further relied upon the
assurance of the managements of ALZA and Abbott that they are not aware of any
facts that would make such information inaccurate or misleading in any material
respect. Chase Securities neither made nor obtained any independent evaluations
or appraisals of the assets or liabilities of ALZA or Abbott, nor did Chase
Securities conduct a physical inspection of the properties and facilities of
ALZA or Abbott. Chase Securities assumed that the financial forecasts provided
to it by ALZA and the financial forecast guidance provided to it by Abbott were
reasonably determined on bases reflecting the best currently available estimates
and judgments of the managements of ALZA and Abbott as to the future financial
performance of ALZA or Abbott, as the case may be. Chase Securities expressed no
view as to such forecast or projection information or the assumptions on which
they were based.

    For purposes of rendering its opinion, Chase Securities assumed that, in all
respects material to its analysis, the representations and warranties of each
party contained in the merger agreement were true and correct, that each party
would perform all of the covenants and agreements required to be performed by it
under the merger agreement and that all conditions to the consummation of the
merger would be satisfied without waiver thereof. Chase Securities further
assumed that all material governmental, regulatory or other consents and
approvals would be obtained and that, in the course of obtaining any necessary
governmental, regulatory or other consents and approvals, or any amendments,
modifications or waivers to any documents to which any of ALZA or Abbott was a
party, as contemplated by the merger agreement, no restrictions would be imposed
or amendments, modifications or waivers made that would have any material
adverse effect on the contemplated benefits to ALZA of the merger. Chase
Securities further assumed that the merger would be accounted for as a
pooling-of-interests under generally accepted accounting principles and that it
would qualify as a tax-free reorganization for U.S. federal income tax purposes.

                                       23
<PAGE>
    In connection with the preparation of its opinion, Chase Securities was not
authorized by ALZA or ALZA's board of directors to solicit, nor did Chase
Securities solicit, third-party indications of interest for the acquisition of
all or any part of ALZA. Chase Securities' opinion was necessarily based on
market, economic and other conditions as they existed and could be evaluated, as
of the date of Chase Securities' opinion. Chase Securities expressed no opinion
as to the merits of the underlying decision by ALZA to engage in the merger. In
addition, Chase Securities expressed no opinion as to the prices at which ALZA
common stock or Abbott common shares would trade following the announcement or
the consummation, as the case may be, of the merger.

    The following is a summary of certain financial and comparative analyses
performed by Chase Securities in arriving at its opinion.

COMPARABLE PUBLIC COMPANIES ANALYSIS

    Using publicly available information, Chase Securities compared certain
financial and operating information and ratios for ALZA with corresponding
financial and operating information and ratios for companies in lines of
business believed to be generally comparable to those of ALZA in the
pharmaceutical industry, as follows:

    - Immunex Corporation

    - Biogen, Inc.

    - Allergan, Inc.

    - Elan Corporation plc

    - Forest Laboratories, Inc.

    - MedImmune, Inc.

    - Watson Pharmaceuticals, Inc.

    - Centocor, Inc.

    - Chiron Corporation

    - Mylan Laboratories, Inc.

    - Teva Pharmaceutical Industries Ltd.

    - Gilead Sciences, Inc.

    - ICOS Corp.

    - IVAX Corp.

    - Jones Pharma Inc.

The analysis indicated that:

    - the ratio of the per share market price of those companies to projected
      earnings per share ranged from 19.3x to 69.4x for calendar year 1999 with
      a median of 30.8x, compared to 27.2x for ALZA, and ranged from 15.8x to
      71.6x for calendar year 2000 with a median of 23.7x, compared to 21.5x for
      ALZA; and

    - the ratio of the per share market price of those companies to projected
      1999 earnings per share compared to projected five-year total return
      ranged from approximately 0.7x to 2.6x, compared to approximately 1.2x for
      ALZA.

    Chase Securities also compared certain financial and operating information
and ratios for Abbott with corresponding financial and operating information and
ratios for the following nineteen largest pharmaceutical companies in terms of
equity market capitalization that were deemed comparable to Abbott:

    - Merck & Co. Inc.

    - Bristol-Myers Squibb Co.

    - Pfizer Inc.

    - Johnson & Johnson Inc.

                                       24
<PAGE>
    - Glaxo Wellcome plc

    - Novartis AG

    - Roche Holdings AG

    - Eli Lilly & Co.

    - SmithKline Beecham plc

    - American Home Products Corporation

    - AstraZeneca

    - Schering-Plough Corporation

    - Warner-Lambert Company

    - Takeda Pharmaceutical Industries Ltd.

    - Aventis Group

    - Amgen Inc.

    - Bayer Corporation

    - Monsanto Co.

    - Pharmacia & Upjohn Inc.

This analysis indicated that:

    - the ratio of the per share market price of those companies to projected
      earnings per share ranged from 17.8x to 66.2x for calendar year 1999 with
      a median of 30.5x, compared to 26.2x for Abbott, and ranged from 16.8x to
      55.0x for calendar year 2000 with a median of 26.7x, compared to 23.4x for
      Abbott; and

    - the ratio of the per share market price of those companies to projected
      1999 earnings per share compared to projected five-year total return
      ranged from approximately 1.4x to 3.3x, compared to approximately 2.0x for
      Abbott.

    Based upon the range of multiples derived from the analysis conducted for
the two sets of companies listed above, Chase Securities also calculated the
implied exchange ratios by comparing the implied per share equity values of ALZA
common stock and Abbott common shares. The analysis yielded the following
implied exchange ratios (rounded to the nearest hundredth), in each case
compared to the proposed exchange ratio of 1.2:

<TABLE>
<CAPTION>
COMPARISON                                                               IMPLIED EXCHANGE RATIO
- ----------------------------------------------------------------------  ------------------------
<S>                                                                     <C>
Highest estimated valuation of ALZA common stock to lowest estimated
  valuation of Abbott common shares...................................              1.02x

Lowest estimated valuation of ALZA common stock to lowest estimated
  valuation of Abbott common shares...................................              0.85x

Highest estimated valuation of ALZA common stock to highest estimated
  valuation of Abbott common shares...................................              0.87x

Lowest estimated valuation of ALZA common stock to highest estimated
  valuation of Abbott common shares...................................              0.73x
</TABLE>

COMPARABLE TRANSACTIONS ANALYSIS

    Chase Securities reviewed certain publicly available information regarding
selected business combinations in the pharmaceutical and health care products
industries announced since May 1994. The comparable transactions and the month
in which each transaction was announced were as follows:

    - Pharmacia & Upjohn Inc./Sugen, Inc. (June 1999)

    - Gilead Sciences, Inc./NeXstar Pharmaceuticals, Inc. (March 1999)

    - Warner-Lambert Company/Agouron Pharmaceuticals, Inc. (January 1999)

    - ALZA Corporation/SEQUUS Pharmaceuticals, Inc. (October 1998)

                                       25
<PAGE>
    - Cardinal Health Inc./RP Scherer Corporation (May 1998)

    - Elan Corporation plc/Neurex Corporation (April 1998)

    - Hoechst AG/Roussel-Uclaf S.A. (December 1996)

    - Abbott Laboratories/MediSense Inc. (March 1996)

    - Elan Corporation plc/Athena Neurosciences, Inc. (March 1996)

    - Rhone-Poulenc Rorer, Inc./Fisons plc (August 1995)

    - Sandoz AG/GTI Corporation (July 1995)

    - Watson Pharmaceuticals, Inc./Circa Pharmaceuticals Inc. (March 1995)

    - Hoechst AG/Marion Merrell Dow, Inc. (February 1995)

    - Glaxo plc/Wellcome plc (January 1995)

    - American Home Products Corporation/American Cynamid Co. (August 1994)

    - Roche Holding AG/Syntex Corp. (May 1994)

    Based upon a price per Abbott common share of $44.00, which was the closing
price per share on June 16, 1999, this analysis indicated that:

    - the transaction value as a percentage premium to the closing prices of the
      target company's stock the day prior to the announcement of the
      transaction ranged from approximately 8% to 66% with a mean of 38%,
      compared to an approximately 31% premium to the closing price per share of
      ALZA common stock on June 16, 1999, and the percentage premium to the
      average closing prices of the target company's stock the month prior to
      the announcement of the transaction ranged from approximately 5% to 86%
      with a mean of 46%, compared to an approximately 42% premium to the
      average closing price per share of ALZA common stock for the month ending
      on June 16, 1999; and

    - the transaction value as a multiple of last-twelve-months revenues ranged
      from approximately 1.7x to 9.5x with a mean of approximately 4.3x,
      compared to 9.5x implied by the merger, and the price as a multiple of
      last-twelve-months earnings per share ranged from 12.9x to 39.0x with a
      mean of 26.6x, compared to 49.0x implied by the merger, adjusted to
      exclude non-recurring charges.

    An analysis of twenty-one other selected transactions in which acquirors
with equity market capitalizations greater than $25.0 billion acquired targets
at values between $1.0 billion and $10.0 billion indicated that:

    - the transaction value as a percentage premium to the closing prices of the
      target company's stock the day prior to the announcement of the
      transaction ranged from approximately (4)% to 80% with a mean of
      approximately 28%; and

    - the percentage premium to the average closing prices of the target
      company's stock the month prior to the announcement of the transaction
      ranged from approximately 11% to 71% with a mean of approximately 38%.

RELATIVE DISCOUNTED CASH FLOW ANALYSIS

    Chase Securities performed a discounted cash flow analysis for each of ALZA
and Abbott using financial forecasts for ALZA provided by ALZA and financial
forecasts for Abbott based on publicly available equity research prepared by
Morgan Stanley Dean Witter. Chase Securities calculated a discounted cash flow
analysis for ALZA assuming discount rates ranging from 13% to 15%, and terminal
multiples of net income in the year 2004 ranging from 24x to 30x, and for Abbott
assuming discount rates ranging from 12% to 14%, and terminal multiples of net
income in the year 2004 ranging from 28x to 32x. Based upon the estimated
valuation ranges of ALZA and Abbott set forth above, Chase Securities calculated
an implied exchange ratio of an Abbott common share to a share of

                                       26
<PAGE>
ALZA common stock. The analysis yielded the following implied exchange ratios
(rounded to the nearest hundredth), in each case compared to the proposed
exchange ratio of 1.2:

<TABLE>
<CAPTION>
COMPARISON                                                               IMPLIED EXCHANGE RATIO
- ----------------------------------------------------------------------  ------------------------
<S>                                                                     <C>
Highest estimated valuation of ALZA common stock to lowest estimated
  valuation of Abbott common share....................................              1.35x

Lowest estimated valuation of ALZA common stock to lowest estimated
  valuation of Abbott common share....................................              1.01x

Highest estimated valuation of ALZA common stock to highest estimated
  valuation of Abbott common share....................................              1.11x

Lowest estimated valuation of ALZA common stock to highest estimated
  valuation of Abbott common share....................................              0.83x
</TABLE>

TRADING RATIO ANALYSIS

    Chase Securities reviewed the per share daily closing market price movements
of ALZA common stock and Abbott common shares for the three-year period ending
June 16, 1999, and calculated the historical exchange ratios during this period
implied by dividing the daily closing prices per share of ALZA common stock by
those of Abbott common shares and the average of those historical trading ratios
for the one-month, 3-months, 6-months, 1-year and 3-years periods ending June
16, 1999. The analysis resulted in the following average historical trading
ratios for the periods indicated (rounded to the nearest hundredth), compared to
the proposed exchange ratio of 1.2:

<TABLE>
<CAPTION>
PERIOD                                                                   HIGH       MEAN        LOW
- ---------------------------------------------------------------------  ---------  ---------  ---------
<S>                                                                    <C>        <C>        <C>
Last 3 Years.........................................................      1.44x      0.99x      0.63x
Last 1 Year..........................................................      1.20x      0.95x      0.63x
Last 6 Months........................................................      1.20x      0.92x      0.63x
Last 3 Months........................................................      1.05x      0.79x      0.63x
Last 1 Month.........................................................      0.93x      0.82x      0.73x
</TABLE>

    Chase Securities also calculated a range of implied exchange ratios by
comparing the high and low closing prices per share of ALZA common stock and
Abbott common shares during the 52-week period ended June 16, 1999. The analysis
yielded the following implied exchange ratios (rounded to the nearest
hundredth), in each case compared to the proposed exchange ratio of 1.2:

<TABLE>
<CAPTION>
COMPARISON                                                               IMPLIED EXCHANGE RATIO
- ----------------------------------------------------------------------  ------------------------
<S>                                                                     <C>
52-week high closing price of ALZA common stock to 52-week low closing
  price of Abbott common shares.......................................              1.52x
52-week low closing price of ALZA common stock to 52-week low closing
  price of Abbott common shares.......................................              0.85x
52-week high closing price of ALZA common stock to 52-week high
  closing price of Abbott common shares...............................              1.05x
52-week low closing price of ALZA common stock to 52-week high closing
  price of Abbott common shares.......................................              0.58x
</TABLE>

CONTRIBUTION ANALYSIS

    Chase Securities estimated the contribution of each of ALZA and Abbott to
the pro forma combined company with respect to revenue and net income for fiscal
years 1999 and 2001 (stand-alone

                                       27
<PAGE>
revenues and net income without synergies). The analysis showed that ALZA would
contribute approximately:

    - 6% of 1999 estimated revenues,

    - 7% of 1999 estimated net income,

    - 7% of 2001 estimated revenues, and

    - 9% of 2001 estimated net income,

compared to the approximately 9% pro forma ownership of the combined company by
ALZA stockholders.

PRO FORMA ANALYSIS

    Chase Securities also analyzed certain pro forma effects resulting from the
merger, including the potential impact of the merger on projected earnings per
share of Abbott following the merger, based on publicly available earnings per
share forecasts as adjusted with guidance provided by Abbott management.
Assuming no synergies, this analysis indicated that the merger would be dilutive
to Abbott shareholders in years 1999, 2000 and 2001.

    The summary set forth above does not purport to be a complete description of
the analyses performed by Chase Securities in arriving at its opinion. Arriving
at a fairness opinion is a complex process not necessarily susceptible to
partial analysis or summary description. Chase Securities believes that its
analyses must be considered as a whole and that selecting portions of analyses
and of the factors considered by it, without considering all such factors and
analyses, could create a misleading view of the processes underlying its
opinion. Chase Securities did not assign relative weights to any of its analyses
in preparing its opinion. The matters considered by Chase Securities in its
analyses were based on numerous macroeconomic, operating and financial
assumptions with respect to industry performance, general business and economic
conditions and other matters, many of which are beyond ALZA's and Abbott's
control and involve the application of complex methodologies and educated
judgment. Any estimates incorporated in the analyses performed by Chase
Securities are not necessarily indicative of actual past or future results or
values, which may be significantly more or less favorable than such estimates.
Estimated values do not purport to be appraisals and do not necessarily reflect
the prices at which businesses or companies may be sold in the future, and such
estimates are inherently subject to uncertainty. None of the comparable
companies used in the "Comparable Public Companies Analysis" described above is
identical to ALZA or Abbott, and none of the comparable transactions used in the
"Comparable Transaction Analysis" described above is identical to the proposed
merger. Accordingly, an analysis of publicly traded comparable companies and
transactions is not mathematical; rather it involves complex considerations and
judgments concerning differences in financial and operating characteristics of
the comparable companies and other factors that could affect the public trading
value of the comparable companies or company to which they are being compared.

    ALZA's board of directors selected Chase Securities to act as its financial
advisor on the basis of Chase Securities' reputation as an internationally
recognized investment banking firm with substantial expertise in transactions
similar to the merger and because it is familiar with ALZA and its business. As
part of its financial advisory business, Chase Securities is continually engaged
in the valuation of businesses and their securities in connection with mergers
and acquisitions and valuations for estate, corporate and other purposes.

    Pursuant to a letter agreement dated June 19, 1999, ALZA has:

       - paid to Chase Securities a nonrefundable retainer of $333,300 upon
         execution of the letter agreement, such amount to be credited against
         any fee payable under the last bullet point below;

       - paid to Chase Securities an additional nonrefundable fee of $3,333,000
         upon execution of the definitive merger agreement, such amount to be
         credited against any fee payable under the next bullet point; and

                                       28
<PAGE>
       - agreed to pay to Chase Securities an additional fee equal to 0.22% of
         the fair market value of the consideration received by holders of ALZA
         common stock upon consummation of the merger, which fee shall be not
         less than $9,999,000.

While the exact amount of the fee payable to Chase Securities under the last
bullet point will not be ascertainable until the closing of the merger, based
upon the closing price per Abbott common share as of June 21, 1999, the fee as
of that date would have been approximately $14.1 million. ALZA has also agreed
to pay Chase Securities the lesser of the fee described in the third bullet
point or 20% of any "break-up," "termination," "topping" or similar fee paid to
ALZA pursuant to or in connection with, the termination, abandonment or failure
to occur, of the merger, within 18 months of the termination of the letter
agreement. In addition, ALZA has also agreed to reimburse Chase Securities for
its reasonable out-of-pocket expenses including the reasonable fees and
disbursements of its legal counsel and to indemnify Chase Securities and certain
related persons from and against certain liabilities in connection with its
engagement, including certain liabilities under the federal securities laws,
arising out of its engagement.

    The Chase Manhattan Corporation and its affiliates, including Chase
Securities, in the ordinary course of business, have from time to time provided
commercial and investment banking services to Abbott, for which they received
usual and customary compensation, and in the future may continue to provide such
commercial and investment banking services. In the ordinary course of business,
Chase Securities and its affiliates may trade in the debt and equity securities
of ALZA and Abbott for their own accounts and for the accounts of their
customers and, accordingly, may at any time hold a long or short position in
such securities.

OPINION OF MERRILL LYNCH & CO. TO ALZA'S BOARD OF DIRECTORS

    On June 21, 1999, Merrill Lynch delivered to ALZA's board of directors a
written opinion to the effect that, as of such date, and based upon and subject
to the factors and assumptions set forth in the opinion, the exchange ratio was
fair from a financial point of view to the holders of ALZA common stock.

    THE FULL TEXT OF MERRILL LYNCH'S FAIRNESS OPINION, WHICH SETS FORTH THE
ASSUMPTIONS MADE, MATTERS CONSIDERED AND QUALIFICATIONS AND LIMITATIONS ON THE
REVIEW UNDERTAKEN BY MERRILL LYNCH, IS ATTACHED AS ANNEX C AND IS INCORPORATED
BY REFERENCE IN THIS PROXY STATEMENT/PROSPECTUS. THE SUMMARY OF MERRILL LYNCH'S
FAIRNESS OPINION SET FORTH IN THIS PROXY STATEMENT/PROSPECTUS IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO THE FULL TEXT OF MERRILL LYNCH'S FAIRNESS OPINION.
ALZA STOCKHOLDERS ARE URGED TO READ SUCH OPINION CAREFULLY AND IN ITS ENTIRETY.

    Merrill Lynch's fairness opinion was provided to ALZA's board of directors
for its information and is directed only to the fairness from a financial point
of view of the exchange ratio. Merrill Lynch's fairness opinion does not address
any other aspect of the merger, including the merits of the underlying decision
by ALZA to engage in the merger, and does not constitute a recommendation to any
ALZA stockholder as to how such stockholder should vote on the proposed merger
agreement or any related matter. The exchange ratio was determined through
negotiations between Abbott and ALZA and was approved by ALZA's board of
directors.

    In arriving at its opinion, Merrill Lynch, among other things:

       - reviewed publicly available business and financial information relating
         to ALZA and Abbott that Merrill Lynch deemed to be relevant;

       - reviewed information, including financial forecasts relating to the
         business, earnings, cash flow, assets, liabilities and prospects of
         ALZA, as well as the amount and timing of the cost savings and related
         expenses and synergies expected to result from the merger, furnished to
         Merrill Lynch by ALZA;

                                       29
<PAGE>
       - conducted discussions with members of senior management and
         representatives of ALZA and Abbott concerning operations, historical
         financial statements and future prospects of ALZA and Abbott, before
         and after giving effect to the merger (and, in the case of the future
         prospects of Abbott, Merrill Lynch was informed by Abbott to rely upon
         public analysts' estimates as the most reasonable estimates for the
         purposes of its opinion);

       - reviewed the market prices and valuation multiples for ALZA common
         stock and Abbott common shares and compared them with those of certain
         publicly traded companies that Merrill Lynch deemed to be relevant;

       - compared the proposed financial terms of the merger with the financial
         terms of other transactions that Merrill Lynch deemed to be relevant;

       - participated in discussions and negotiations among representatives of
         ALZA and Abbott and their financial and legal advisors;

       - reviewed the potential pro forma impact of the merger;

       - reviewed the merger agreement; and

       - reviewed such other financial studies and analyses and took into
         account such other matters as Merrill Lynch deemed necessary, including
         Merrill Lynch's assessment of general economic, market and monetary
         conditions.

    In preparing its opinion, Merrill Lynch assumed and relied on the accuracy
and completeness of all information supplied or otherwise made available to
Merrill Lynch, discussed with or reviewed by or for Merrill Lynch, or publicly
available, and Merrill Lynch did not assume any responsibility for independently
verifying such information and Merrill Lynch has not undertaken an independent
evaluation or appraisal of any of the assets or liabilities of ALZA or Abbott or
been furnished with any such evaluation or appraisal. In addition, Merrill Lynch
did not assume any obligation to conduct any physical inspection of the
properties or facilities of ALZA or Abbott. With respect to the financial
forecast information and information concerning the cost savings and related
expenses and synergies expected to result from the merger furnished to or
discussed with Merrill Lynch by ALZA and the financial forecast guidance
provided to Merrill by Abbott, Merrill Lynch assumed that they had been
reasonably prepared and reflected the best available estimates and judgment of
ALZA's or Abbott's management as to the expected future financial performance of
ALZA or Abbott, as the case may be, and the cost savings and related expenses
and synergies expected to result from the merger. Merrill Lynch further assumed
that the merger will be accounted for as a pooling-of-interests under generally
accepted accounting principles and that it will qualify as a tax-free
reorganization for U.S. federal income tax purposes.

    Merrill Lynch's fairness opinion is necessarily based on market, economic
and other conditions as they existed and could be evaluated on, and on the
information made available to Merrill Lynch as of, the date of the opinion.
Merrill Lynch assumed that in the course of obtaining the necessary regulatory
or other consents or approvals (contractual or otherwise) for the merger, no
restrictions, including any divestiture requirements or amendments or
modifications, will be imposed that will have a material adverse effect on the
contemplated benefits of the merger. Merrill Lynch did not express any opinion
as to the prices at which ALZA common stock or Abbott common shares will trade
following the announcement or consummation of the merger. In connection with the
preparation of its opinion, Merrill Lynch was not authorized by ALZA or ALZA's
board of directors to solicit, nor did Merrill Lynch solicit, third-party
indications of interest for the acquisition of all or any part of ALZA. Although
Merrill Lynch evaluated the exchange ratio from a financial point of view,
Merrill Lynch was not requested to, and did not, address the merits of the
underlying decision of ALZA to engage in the merger and did not recommend to any
stockholder as to how such stockholder should vote on the proposed merger or any
related matter.

                                       30
<PAGE>
    In preparing its opinion to ALZA's board of directors, Merrill Lynch
performed financial and comparative analyses, including those described below.
The summary of analyses set forth in this proxy statement/prospectus does not
purport to be a complete description of the analyses underlying Merrill Lynch's
fairness opinion or the presentation made by Merrill Lynch to ALZA's board of
directors. The preparation of a fairness opinion is a complex analytic process
involving various determinations as to the most appropriate and relevant methods
of financial analysis and the application of those methods to the particular
circumstances and, therefore, such an opinion is not readily susceptible to
partial analysis or summary description. No company, business or transaction
used in such analyses as a comparison is identical to ALZA, Abbott or the
merger, nor is an evaluation of the results of such analyses entirely
mathematical, rather it involves complex considerations and judgments concerning
financial and operating characteristics and other factors that could affect the
acquisition, public trading or other values of the companies, business segments
or transactions being analyzed.

    In arriving at its opinion, Merrill Lynch did not attribute any particular
weight to any analysis or factor considered by it, but rather made qualitative
judgments as to the significance and relevance of each analysis and factor.
Accordingly, Merrill Lynch believes that its analyses must be considered as a
whole and that selecting portions of its analyses, without considering all
analyses, would create an incomplete view of the process underlying its opinion.

    In performing its analyses, numerous assumptions were made with respect to
industry performance, general business, economic, market and financial
conditions and other matters, many of which are beyond the control of Merrill
Lynch, ALZA or Abbott. The estimates contained in the analyses performed by
Merrill Lynch and the ranges of valuations resulting from any particular
analysis are not necessarily indicative of actual values or predictive of future
results or values, which may be significantly more or less favorable than those
suggested by such analyses. Additionally, estimates of the value of businesses
or securities do not purport to be appraisals or to reflect the prices at which
such businesses or securities might actually be sold. Accordingly, such analyses
and estimates are inherently subject to substantial uncertainty. In addition, as
described above, Merrill Lynch's fairness opinion was among several factors
taken into consideration by ALZA's board of directors in making its
determination to approve the merger agreement and the merger. Consequently, the
Merrill Lynch analyses described below should not be viewed as determinative of
the decision of ALZA's board of directors or ALZA's management with respect to
the fairness of the exchange ratio.

    The following is a summary of the material financial and comparative
analyses performed by Merrill Lynch in arriving at its June 21, 1999 opinion and
presented to ALZA's board of directors. The Merrill Lynch opinion is based upon
Merrill Lynch's consideration of the collective results of all such analyses,
together with the other factors referred to in its opinion letter.

EXCHANGE RATIO ANALYSIS

    In the merger, each outstanding share of ALZA common stock will be converted
into the right to receive 1.2 Abbott common shares. Merrill Lynch compared this
exchange ratio to each range of implied exchange ratios set forth below, which
were derived from analyses performed by Merrill Lynch, and noted that this
exchange ratio was higher than or in the range of such implied exchange ratios.

<TABLE>
<CAPTION>
                                                                                  EXCHANGE RATIO
                                                                               --------------------
METHODOLOGY                                                                       LOW       HIGH
- -----------------------------------------------------------------------------  ---------  ---------
<S>                                                                            <C>        <C>
Historical share price analysis..............................................      0.792      0.955
Comparable company trading analysis..........................................      0.640      1.071
Contribution analysis........................................................      0.814      0.931
Discounted cash flow analysis................................................      0.978      1.480
</TABLE>

                                       31
<PAGE>
HISTORICAL SHARE PRICE ANALYSIS

    Merrill Lynch analyzed the ratio of the daily closing share prices of ALZA
common stock to corresponding prices of Abbott common shares for the one year
period ended June 16, 1999, calculated the average daily closing per share
prices for the periods listed below and, based on such averages, calculated the
implied exchange ratios listed below.

<TABLE>
<CAPTION>
PERIOD                                                                  IMPLIED EXCHANGE RATIO
- ----------------------------------------------------------------------  -----------------------
<S>                                                                     <C>
1 month...............................................................             0.825
3 months..............................................................             0.792
6 months..............................................................             0.922
1 year................................................................             0.955
</TABLE>

    Based on this historical share price analysis, Merrill Lynch calculated an
implied exchange ratio range of 0.792 to 0.955.

COMPARABLE COMPANY TRADING ANALYSIS

    Using publicly available information, Merrill Lynch compared selected
historical and estimated stock price and financial ratios for groups of selected
publicly traded companies in the pharmaceuticals industry considered by Merrill
Lynch to be reasonably comparable to ALZA and Abbott, respectively, for the
purposes of this analysis. The companies comparable to ALZA included:

    - Allergan, Inc.

    - Elan Corporation plc

    - Forest Laboratories, Inc.

    - Mylan Laboratories, Inc.

    - Teva Pharmaceutical Industries Ltd.

    - Watson Pharmaceuticals, Inc.

The companies comparable to Abbott included:

    - American Home Products Corporation

    - AstraZeneca plc

    - Bristol-Myers Squibb Co.

    - Eli Lilly & Co.

    - Glaxo Wellcome plc

    - Johnson & Johnson, Inc.

    - Merck & Co. Inc.

    - Novartis AG

    - Pfizer Inc.

    - Pharmacia & Upjohn Inc.

    - Roche Holdings AG

    - Schering-Plough Corporation

    - SmithKline Beecham plc

    - Warner-Lambert Company

    Merrill Lynch calculated the price of each of the comparable companies'
common stock as a multiple of (1) estimated 1999 earnings per share and (2)
estimated 2000 earnings per share. Merrill Lynch also calculated the 2000
price-to-earnings ratio of each of the comparable companies as a multiple of
estimated total return (defined to be the estimated 5 year earnings per share
growth rate plus the current dividend yield, defined to be the quotient of (1)
four times the most recent quarterly dividend per share, and (2) the stock
price). Additionally, Merrill Lynch compared the market capitalization (defined
to be the market value of the common stock plus preferred equity at liquidation

                                       32
<PAGE>
value, total debt and minority interest less cash and marketable securities) of
each of the comparable companies as a multiple of estimated 1999 earnings before
interest and taxes (defined to be income (loss) before interest expense, income
taxes and certain nonrecurring items). This analysis indicated that:

    - the 1999 price-to-earnings ratio for the companies comparable to ALZA
      ranged from 21x to 30x;

    - the 2000 price-to-earnings ratio for the companies comparable to ALZA
      ranged from 17x to 24x;

    - market capitalization as a multiple of estimated 1999 earnings before
      interest and taxes for the companies comparable to ALZA ranged from 15x to
      23x;

    - the 2000 price-to-earnings to total return ratio for the companies
      comparable to ALZA ranged from 0.75x to 1.20x;

    - the 1999 earnings before interest and taxes ratio for the companies
      comparable to Abbott ranged from 26x to 30x;

    - the 2000 earnings before interest and taxes ratio for the companies
      comparable to Abbott ranged from 23x to 27x;

    - market capitalization as a multiple of estimated 1999 earnings before
      interest and taxes for the companies comparable to Abbott ranged from 18x
      to 23x; and

    - the 2000 earnings before interest and taxes to total return ratio for the
      companies comparable to Abbott ranged from 1.60x to 1.85x.

    Based upon a comparison of the companies comparable to ALZA and the
companies comparable to Abbott, the implied exchange ratio ranged from 0.640x to
1.071x.

    Because of the inherent differences among the operations of ALZA, Abbott and
the selected comparable companies, Merrill Lynch believes that a purely
quantitative comparable company analysis would not be dispositive in the context
of the merger. Merrill Lynch further believes that an appropriate use of a
comparable company analysis in this instance involves qualitative judgments
concerning differences among the financial and operating characteristics of
ALZA, Abbott and the selected comparable companies, which judgments are
reflected in the Merrill Lynch opinion.

CONTRIBUTION ANALYSIS

    To determine an implied exchange ratio range based upon a contribution
analysis, Merrill Lynch calculated the contribution on a percentage basis of
each of ALZA and Abbott to the estimated net income to common stockholders of
the pro forma combined company for the twelve month periods ending December 31,
1999 and 2000 (excluding the effect of any cost savings and related expenses and
synergies expected to result from the merger) using projections provided by the
management of ALZA and information in selected equity research reports on
Abbott.

    The results of these calculations indicated that ALZA's net income
contribution percentages would be 6.8% and 7.7% for the twelve month periods
ending December 31, 1999 and December 31, 2000, respectively. Merrill Lynch
noted that if former stockholders of ALZA were to own like percentages of the
equity of the combined company as the ALZA net income contribution percentages
for the twelve month periods ending December 31, 1999 and December 31, 2000, the
implied exchange ratios would be 0.814x and 0.931x, respectively.

                                       33
<PAGE>
DISCOUNTED CASH FLOW ANALYSIS

    To determine an implied exchange ratio range based upon discounted cash flow
analysis, Merrill Lynch performed discounted cash flow analyses for each of ALZA
and Abbott using projections provided to Merrill Lynch by the management of ALZA
and information in selected equity research reports on Abbott and calculated
ranges of values per share for ALZA common stock and Abbott common shares.

    Discount rates ranging from 12.0% to 14.0% were applied to ALZA's projected
free cash flows for the years 1999 through 2004 and enterprise value in 2004
based on a range of multiples of estimated unlevered 2004 net income of 22.0x to
26.0x. Discount rates ranging from 11.0% to 13.0% were applied to Abbott's
projected free cash flows for the years 1999 through 2004 and enterprise value
in 2004 based on a range of multiples of estimated unlevered 2004 net income of
26.0x to 30.0x.

    Based upon a comparison of high-to-low estimated equity values per share for
each of ALZA and Abbott resulting from the discounted cash flow analyses, the
implied exchange ratios ranged from 0.978x to 1.480x.

COMPARABLE TRANSACTION ANALYSIS

    Merrill Lynch also reviewed publicly available information relating to
comparable merger and acquisition transactions involving pharmaceutical
companies. With respect to ALZA, Merrill Lynch examined multiples of the
consideration paid for the common equity and the value of the indebtedness, less
cash and cash equivalents assumed in each of the transactions to, among other
measures, such acquired companies' latest twelve months earnings before interest
and taxes, and examined multiples of the price per share in each of the
transactions to current year earnings per share.

    The comparable transactions in the pharmaceutical industry that Merrill
Lynch reviewed were the following:

    - twenty-two pharmaceutical acquisitions completed over the past five years;
      and

    - four selected comparable pharmaceutical acquisitions:

          -- the acquisition of NeXstar Pharmaceuticals, Inc. by Gilead
             Sciences, Inc.

          -- the acquisition of Agouron Pharmaceutical, Inc. by Warner-Lambert
             Company

          -- the acquisition of TheraTech, Inc. by Watson Pharmaceuticals, Inc.

          -- the acquisition of RP Scherer Corporation by Cardinal Health Inc.

    This analysis indicated that the latest twelve month earnings before
interest and taxes multiples ranged from 17x to 23x and current year
price-to-earnings ratios ranged from 20x to 25x for the twenty-two
pharmaceutical transactions and latest twelve month earnings before interest and
taxes multiples ranged from 23x to 49x and current year price-to-earnings ratios
ranged from 27x to 34x for the four selected pharmaceutical acquisitions.

    Applying these multiples for the twenty-two comparable acquisitions in the
pharmaceutical industry and the four selected comparable pharmaceutical
acquisitions to corresponding financial data of ALZA indicated an implied equity
reference range for its common stock of $30.00 to $40.85 per share and $40.50 to
$80.70 per share, respectively.

    Because the reasons for, and circumstances surrounding, each of the
comparable transactions analyzed were so diverse and due to the inherent
differences between the operations and financial conditions of ALZA and the
selected companies, Merrill Lynch believes that a purely quantitative comparable
transaction analysis would not be dispositive in the context of the merger.
Merrill Lynch further believes that an appropriate use of a comparable
transaction analysis in this instance involves

                                       34
<PAGE>
qualitative judgments concerning the differences between the characteristics of
these transactions and the merger that would affect the value of the acquired
companies and businesses and ALZA, those judgments being reflected in the
Merrill Lynch opinion.

MERGER PREMIUM ANALYSIS

    Merrill Lynch examined premiums paid for the targets' equity over
pre-announcement stock prices one day prior to announcement, one week prior to
announcement and four weeks prior to announcement in the twenty-two comparable
acquisitions in the pharmaceutical industry and the four selected comparable
pharmaceutical acquisitions. The average premiums ranged from 25.0% to 49.2%,
indicating an implied equity value reference range for ALZA common stock of
$50.63 per share to $64.42 per share.

    Because the reasons for, and circumstances surrounding, each of the
transactions analyzed were different, Merrill Lynch believes that a purely
quantitative merger premium analysis would not be dispositive in the context of
the merger. Merrill Lynch further believes that an appropriate use of a merger
premium analysis in this instance involves qualitative judgments concerning the
differences between the characteristics of these transactions and the merger
that would affect the value of the acquired companies and businesses and ALZA,
which judgments are reflected in the Merrill Lynch opinion.

PRO FORMA MERGER ANALYSIS

    Merrill Lynch analyzed certain pro forma effects which could result from the
merger, based on financial forecasts for ALZA provided by ALZA's management for
each year through 2004 and information in selected equity research reports on
Abbott for the same period. ALZA's management advised Merrill Lynch that the
merger will be accounted for as a "pooling-of-interests" under U.S. generally
accepted accounting principles. This pro forma analysis indicated that (1) for
fiscal 2000 the merger would be dilutive to the forecasted earnings per share of
Abbott if those cost savings were $50 million per year or less, and accretive to
such earnings if those cost savings were $100 million per year or more, and (2)
for fiscal 2001 the merger would be dilutive to such forecasted earnings if no
such savings were achieved and accretive if savings of $50 million or more per
year were achieved.

OTHER FACTORS AND ANALYSES

    In the course of preparing its opinion, Merrill Lynch performed other
analyses and reviewed other matters, including, among other things:

    - historical and expected trading characteristics of ALZA common stock and
      Abbott common shares; and

    - pro forma operating results and capitalization of the combined company.

    Pursuant to the terms of the Merrill Lynch letter agreement, ALZA has agreed
to pay the following fees to Merrill Lynch for its financial advisory services
in connection with the merger:

    - a fee of $166,700, payable in cash on the date of the Merrill Lynch letter
      agreement;

    - an additional fee of $1,667,000, contingent upon and payable in cash upon
      the execution of a definitive agreement to effect a business combination
      as defined in the Merrill Lynch letter agreement; and

    - if, during the period Merrill Lynch is retained by ALZA or within 18
      months thereafter, a business combination is consummated with an acquiror
      as defined in the Merrill Lynch letter agreement, or ALZA enters into an
      agreement with an acquiror that subsequently results in a business
      combination as defined in the Merrill Lynch letter agreement, an
      additional fee in an

                                       35
<PAGE>
      amount equal to 0.11% of the aggregate purchase price paid in such
      business combination (but not less than $5,000,000), payable in cash upon
      the closing of such business combination; provided, however, that any fees
      previously paid to Merrill Lynch pursuant to the previous two bullet
      points shall be deducted from any fee to which Merrill Lynch is entitled
      pursuant to this bullet point.

    Although the exact amount of the fee payable to Merrill Lynch under the last
bullet point will not be ascertainable until the effective time of the merger,
based upon the closing price per Abbott common shares as of June 21, 1999, the
fee as of that date would have been approximately $7,100,000. ALZA has also
agreed to pay Merrill Lynch the lesser of the aggregate fees described above
payable to Merrill Lynch if the merger were consummated and 10% of any
"break-up," "termination," "topping" or similar fee paid to ALZA pursuant to or
in connection with, the termination, abandonment or failure to occur, of the
merger, within 18 months of the termination of the letter agreement. ALZA also
has agreed to reimburse Merrill Lynch for all reasonable out-of-pocket expenses
incurred by Merrill Lynch in performing its services, including the fees and
expenses for legal counsel, and to indemnify Merrill Lynch and related persons
and entities against liabilities under federal or state law arising out of a
business combination contemplated by the letter agreement or the engagement of
Merrill Lynch pursuant to the letter agreement.

    ALZA retained Merrill Lynch based upon Merrill Lynch's experience and
expertise. Merrill Lynch is an internationally recognized investment banking
business, is regularly engaged in the valuation of businesses and securities in
connection with mergers and acquisitions, negotiated underwritings, competitive
biddings, secondary distributions of listed and unlisted securities, private
placements and valuations for corporate and other purposes.

    In the ordinary course of business, Merrill Lynch and its affiliates may
actively trade in securities of ALZA and Abbott for their own accounts and for
the accounts of customers and, accordingly, may at any time hold a long or short
position in such securities.

STRUCTURE OF THE MERGER

    At the effective time of the merger, AC Merger Sub will merge with and into
ALZA, and the separate corporate existence of AC Merger Sub will end. ALZA will
be the surviving corporation in the merger and a wholly owned subsidiary of
Abbott, and will continue to be a Delaware corporation after the merger.

    The certificate of incorporation and bylaws of AC Merger Sub immediately
prior to the effective time of the merger will be the certificate of
incorporation and bylaws of the surviving corporation at the effective time of
the merger until duly amended. The directors of AC Merger Sub at the effective
time of the merger will be the directors of the surviving corporation. The
officers of ALZA at the effective time of the merger will be the officers of the
surviving corporation.

WHEN THE MERGER BECOMES EFFECTIVE

    AC Merger Sub and ALZA will execute and file with the Secretary of State of
the State of Delaware a certificate of merger as soon as practicable after the
second business day on which the last of the closing conditions to the
completion of the merger is fulfilled or waived or such other time and date as
they may agree. The merger will become effective at the time and on the date on
which the certificate of merger is filed with the Secretary of State of the
State of Delaware or such other time upon which the parties agree and specify in
the certificate of merger. That time is the "effective time of the merger."

                                       36
<PAGE>
CONVERSION OF STOCK, STOCK OPTIONS AND OTHER AWARDS

    At the effective time of the merger:

       - each outstanding share of ALZA common stock, other than shares of ALZA
         common stock owned by Abbott, ALZA or any direct or indirect subsidiary
         of Abbott or ALZA, will be converted into 1.2 Abbott common shares;

       - shares of ALZA common stock owned by Abbott, ALZA or any direct or
         indirect subsidiary of Abbott or ALZA will be canceled; and

       - ALZA will become a wholly owned subsidiary of Abbott.

    If, before the effective time of the merger, the issued and outstanding
Abbott common shares are changed into a different number of shares or a
different class of shares as a result of a stock split, reverse stock split,
stock dividend, spinoff, recapitalization, reclassification or other similar
transaction, an appropriate adjustment will be made to the number or kind of
Abbott common shares which holders of shares of ALZA common stock are to receive
in the merger.

    No fractional Abbott common shares will be issued in the merger. Instead of
issuing fractional Abbott common shares, Abbott will pay cash in an amount equal
to such fraction, rounded to the nearest one-hundredth of a share, multiplied by
the average of the closing prices for an Abbott common share as reported in The
Wall Street Journal, New York City edition, on the five trading days immediately
prior to the effective time of the merger.

    At or prior to the effective time of the merger, Abbott will deposit with
BankBoston, in trust for the benefit of ALZA stockholders, certificates
representing the Abbott common shares to be issued and cash to be paid in lieu
of fractional shares pursuant to the merger agreement in exchange for
outstanding ALZA common stock.

    At the effective time of the merger, the stock transfer books of ALZA will
be closed and no further transfers of shares of ALZA common stock will be made.
If, after the effective time, ALZA stock certificates are presented to the
surviving corporation for any reason, they will be canceled and exchanged as
described above.

    Promptly after the effective time of the merger, BankBoston will mail a
letter of transmittal to the holders of ALZA common stock containing
instructions with respect to the surrender of certificates representing ALZA
common stock. ALZA COMMON STOCK CERTIFICATES SHOULD NOT BE RETURNED WITH THE
ENCLOSED PROXY OR SENT TO ABBOTT OR ALZA, AND SHOULD NOT BE FORWARDED TO
BANKBOSTON UNLESS AND UNTIL A HOLDER OF SHARES OF ALZA COMMON STOCK RECEIVES THE
LETTER OF TRANSMITTAL.

    If any certificates for Abbott common shares are to be issued in a name
other than that in which the ALZA stock certificate surrendered in exchange
therefor is registered, the person requesting such exchange must (1) pay to
Abbott or any agent designated by it any transfer or other taxes required by
reason thereof or (2) establish to the satisfaction of Abbott or any agent
designated by it that such tax has been paid or is not applicable.

    BankBoston will deduct and withhold from the consideration otherwise payable
pursuant to the merger agreement such amounts as BankBoston is required to
deduct and withhold under the Internal Revenue Code, or any provision of state,
local or foreign tax law, with respect to the making of such payment. To the
extent that amounts are withheld by BankBoston, the withheld amounts shall be
treated for purposes of the merger agreement as having been paid to the person
in respect of whom the deduction and withholding was made by BankBoston.

    Until the certificates representing ALZA common stock are surrendered for
exchange after the effective time of the merger, holders of such certificates
will accrue, but will not be paid, dividends or other distributions declared and
with a record date after the effective time of the merger with respect

                                       37
<PAGE>
to Abbott common shares into which their shares have been converted. When such
certificates are surrendered, any unpaid dividends or other distributions will
be paid. No interest will be paid or accrued on the cash in lieu of fractional
shares, if any, and unpaid dividends and distributions, if any, payable to
holders of ALZA common stock certificates. Registered holders of unsurrendered
ALZA common stock certificates will be entitled to vote after the effective time
of the merger at any meeting of Abbott shareholders with a record date at or
after the effective time of the merger the number of whole Abbott common shares
represented by such ALZA common stock certificates, regardless of whether such
holders have exchanged their ALZA common stock certificates. None of Abbott,
ALZA, AC Merger Sub or BankBoston, or any other person will be liable to any
former holder of ALZA common stock for any amount properly delivered to a public
official pursuant to applicable abandoned property, escheat or similar laws.

    If a certificate for ALZA common stock has been lost, stolen or destroyed,
BankBoston will issue the consideration properly payable in accordance with the
merger agreement upon receipt of appropriate evidence as to such loss, theft or
destruction, appropriate evidence as to the ownership of such certificate by the
claimant and appropriate and customary indemnification.

    Each option to purchase ALZA common stock granted under ALZA's stock plans
that is outstanding and unexercised as of the effective time of the merger will
vest, will be converted automatically at the effective time of the merger into,
and will become, an option to purchase 1.2 Abbott common shares for each share
of ALZA common stock covered by the option before the merger. After conversion,
the exercise price per Abbott common share subject to each option will equal its
pre-conversion exercise price per share of ALZA common stock subject to such
option divided by 1.2. Stock purchase rights and restricted stock outstanding
will be similarly converted.

    For a description of Abbott's common shares and a description of the
differences between the rights of holders of Abbott common shares and ALZA
common stock, see "Comparison of Rights of Abbott Shareholders and ALZA
Stockholders."

CONVERTIBLE DEBT AND WARRANTS

    At the effective time of the merger, each outstanding 5% convertible
subordinated debenture due 2006 will remain a debenture of ALZA, but will become
convertible into Abbott common shares. The 5% debentures will continue to be
governed by the terms of ALZA's 5% debenture indenture; however, at the
effective time of the merger, ALZA and Abbott will execute a supplemental
indenture providing that the 5% debentures will be convertible into the number
of Abbott common shares obtained by dividing the principal amount of the 5%
debenture or portion thereof surrendered for conversion by the adjusted
conversion price of $31.825. If the merger takes place, holders of the 5%
debentures will have the right to have their debentures repurchased at a price
equal to 100% of the principal amount of the debentures plus any accrued but
unpaid interest. Within 15 days after the merger, a notice of the merger and the
repurchase right triggered by the merger will be sent to each holder of the 5%
debentures. Holders will have 30 days from the date of the notice to exercise
the repurchase right.

    At the effective time of the merger, each outstanding 5 1/4% zero coupon
convertible subordinated debenture due 2014 will remain a debenture of ALZA, but
will become convertible into Abbott common shares. The 5 1/4% debentures will
continue to be governed by the terms of ALZA's 5 1/4% debenture indenture;
however, at the effective time of the merger, ALZA and Abbott will execute a
supplemental indenture providing that the 5 1/4% debentures will be convertible
into the number of Abbott common shares obtained by multiplying each $1,000
principal amount at maturity of the 5 1/4% debenture or portion thereof
surrendered for conversion by the adjusted conversion rate of 15.5844.

    At the effective time of the merger, each holder of a warrant to purchase
one-eighth of a share of ALZA common stock will have the right to purchase 0.15
Abbott common shares. The warrants will continue to be governed by the terms of
ALZA's warrant agreement; however, at the effective time of

                                       38
<PAGE>
the merger, ALZA and Abbott will execute a supplement to the warrant agreement
providing that the warrants will be exercisable at an exercise price of
approximately $54.17 per full Abbott common share.

REPRESENTATIONS AND WARRANTIES

    The merger agreement contains representations and warranties of ALZA as to,
among other things:

    - the corporate organization, existence and good standing of ALZA and its
      subsidiaries;

    - ALZA's capitalization;

    - the corporate power and authority of ALZA to execute, deliver and perform
      the merger agreement and to complete the merger;

    - the unanimous approval and declaration of advisability of the merger
      agreement and the merger and the other transactions contemplated by the
      merger agreement by ALZA's board of directors;

    - the receipt by ALZA's board of directors of the opinions of Chase
      Securities and Merrill Lynch to the effect that the exchange ratio in the
      merger is fair to the holders of ALZA common stock from a financial point
      of view;

    - the absence of any required governmental and third-party approvals other
      than those specified in the merger agreement;

    - the timely filing of required regulatory reports;

    - the accuracy of ALZA's financial statements and filings with the
      Securities and Exchange Commission;

    - the absence of certain changes in ALZA's business since December 31, 1998;

    - the absence of undisclosed litigation and liabilities;

    - ALZA's employee benefits plans;

    - ALZA's compliance with applicable law;

    - ALZA's taking all appropriate and necessary actions to permit Abbott and
      AC Merger Sub to enter into business combinations with ALZA;

    - the absence of undisclosed environmental matters;

    - the absence of any actions that would prevent the merger from being
      treated as a pooling-of-interests from an accounting standpoint and as a
      tax-free reorganization;

    - ALZA's timely payment of all taxes;

    - ALZA's relationship with its employees;

    - the absence of undisclosed brokers and finders;

    - ALZA's compliance with regulatory requirements;

    - ALZA's disclosure of its significant agreements;

    - ALZA's ownership or right to use all intellectual property material to
      ALZA's business;

    - ALZA's preparedness with respect to Year 2000 compliance; and

    - ALZA's interests in Crescendo, including ALZA's ownership of all of
      Crescendo's class B common stock and ALZA's option to purchase all of
      Crescendo's publicly traded class A common stock.

                                       39
<PAGE>
    The merger agreement contains representations and warranties of Abbott and
AC Merger Sub as to, among other things:

    - their corporate organization, existence and good standing;

    - their capitalization;

    - their corporate power and authority to execute, deliver and perform the
      merger agreement and to complete the merger;

    - the absence of any required governmental and third-party approvals other
      than those specified in the merger agreement;

    - their timely filing of required regulatory reports;

    - the accuracy of their financial statements and filings with the Securities
      and Exchange Commission;

    - the absence of certain changes in their businesses since December 31,
      1998;

    - the absence of any actions that would prevent the merger from being
      treated as a pooling-of-interests from an accounting standpoint and as a
      tax-free reorganization; and

    - Abbott's intent to cause the surviving corporation to continue to maintain
      significant operations in the Silicon Valley area of California.

CERTAIN COVENANTS

    The merger agreement provides that ALZA, as to itself and its subsidiaries,
will, prior to the effective time of the merger, except as agreed to in writing
by Abbott or as contemplated by the merger agreement:

    - conduct its business in the ordinary and usual course;

    - not to do any of the following:

          -- amend its certificate of incorporation or bylaws,

          -- split, combine, subdivide or reclassify its outstanding shares of
             capital stock,

          -- declare, set aside or pay any dividend payable in cash, stock or
             property in respect of any capital stock, or

          -- repurchase, redeem or otherwise acquire, except in connection with
             commitments existing as of the date of the merger agreement,
             including under the ALZA stock plans, but subject to ALZA's
             obligations described in the next bullet point, or permit any of
             its subsidiaries to purchase or otherwise acquire, any shares of
             its capital stock, or any securities convertible into or
             exchangeable or exercisable for any shares of its capital stock;

    - not take any action that would prevent the merger from qualifying for
      pooling-of-interests accounting treatment or as a tax-free reorganization
      under the Internal Revenue Code:

    - not to take any action that would cause any of its representations and
      warranties to become untrue in any material respect;

    - not take certain actions related to employee benefits plans or employee
      compensation;

                                       40
<PAGE>
    - not incur, repay or retire prior to maturity or refinance any indebtedness
      for borrowed money or guarantee any such indebtedness or issue, sell,
      repurchase or redeem prior to maturity any debt securities or warrants or
      rights to acquire any debt securities or guarantee any debt securities of
      others, in all such cases in excess of, in the aggregate, $10,000,000 plus
      amounts equal to any existing indebtedness described under "The Merger
      Agreement and the Merger--Convertible Debt and Warrants" that ALZA is
      required to repurchase prior to the effective time of the merger;

    - not make any capital expenditures in an aggregate amount in excess of the
      aggregate amount reflected in ALZA's capital expenditure budget for the
      fiscal year ending December 31, 1999;

    - not issue, deliver, sell, pledge or encumber shares of any class of its
      capital stock or any securities convertible or exchangeable into, any
      rights, warrants or options to acquire, or any bonds, debentures, notes or
      other debt obligations having the right to vote or convertible or
      exercisable for any such shares except ALZA common stock issued pursuant
      to options and other awards outstanding on the date of the merger
      agreement under the ALZA stock plans or as otherwise permitted under the
      merger agreement;

    - not authorize, propose or announce an intention to authorize or propose,
      or enter into an agreement with respect to, any merger, consolidation or
      business combination (other than the merger), or any purchase, sale,
      lease, license or other acquisition or disposition of any business or of a
      material amount of assets or securities;

    - not make any material change in its accounting policies or procedures,
      other than any such change that is required by generally accepted
      accounting principles, or revalue any assets, including, without
      limitation, writing down the value of material inventory or writing off
      notes or accounts receivable in a material amount other than as required
      by generally accepted accounting principles; and

    - not release, assign, settle or compromise any material claims or
      litigation or make any material tax election or settle or compromise any
      material United States federal, state, local or foreign tax liability.

    The merger agreement also provides that Abbott, as to itself and its
subsidiaries, will, prior to the effective time of the merger, except as agreed
to in writing by ALZA or as contemplated by the merger agreement:

    - remain principally a diversified health care products and services
      company;

    - not to do any of the following:

          -- reclassify its shares of capital stock or

          -- declare, set aside or pay any dividend payable in cash, stock
             (other than Abbott common shares) or property in respect of any
             capital stock, except (x) for regular quarterly cash dividends or
             (y) for a dividend that would be received by the holders of the
             ALZA common stock on an equivalent basis per Abbott common share
             after the effective time of the merger;

    - not take any action that would prevent the merger from qualifying for
      pooling-of-interests accounting treatment or as a tax-free reorganization
      under the Internal Revenue Code or that would cause any of its
      representations and warranties in the merger agreement to become untrue in
      any material respect; and

    - not authorize, propose or announce an intention to authorize or propose,
      or enter into an agreement with respect to, any merger, consolidation or
      business combination, or any purchase,

                                       41
<PAGE>
      sale, lease, license or other acquisition of any business or a material
      amount of assets or securities, in all such cases, with certain entities
      identified by ALZA.

NON-SOLICITATION OF COMPETING PROPOSALS

    The merger agreement provides that:

    - neither ALZA nor any of its subsidiaries nor any of the officers and
      directors of it or its subsidiaries will, and that ALZA will direct and
      use its best efforts to cause its and its subsidiaries' employees, agents
      and representatives not to, initiate, solicit, encourage or otherwise
      facilitate any inquiries or the making of any acquisition proposal, which
      is defined to mean any proposal or offer with respect to a merger,
      reorganization, share exchange, consolidation, business combination,
      recapitalization, liquidation, dissolution or similar transaction
      involving ALZA, or any purchase or sale of the consolidated assets of ALZA
      or any of its subsidiaries, taken as a whole, having an aggregate value
      equal to 10% or more of its market capitalization, or any purchase or sale
      of, or tender or exchange offer for, 10% or more of its or any of its
      subsidiaries' equity securities; and

    - neither ALZA nor any of its subsidiaries nor any of the officers and
      directors of it or its subsidiaries will, and ALZA will direct and use its
      best efforts to cause ALZA's representatives not to, have any discussion
      with or provide any confidential information or data to any person
      relating to or in contemplation of an acquisition proposal or engage in
      any negotiations concerning an acquisition proposal, or otherwise
      facilitate any effort or attempt to make or implement an acquisition
      proposal; provided, however, that nothing contained in the merger
      agreement will prevent either ALZA or its board of directors from:

          -- complying with the requirements of the Securities Exchange Act of
             1934 with regard to an acquisition proposal;

          -- engaging in any discussions or negotiations with or providing any
             information to, any person in response to an unsolicited bona fide
             written acquisition proposal by any such person; or

          -- subject to the obligation of ALZA to duly convene the meeting to
             which this proxy statement/prospectus relates, recommending such an
             unsolicited bona fide written acquisition proposal to the
             stockholders if, and only to the extent that,

    with respect to the actions referred to in the second and third items above,

       (1) ALZA's board of directors concludes in good faith that such
           acquisition proposal is reasonably capable of being completed, taking
           into account all legal, financial, regulatory and other aspects of
           the proposal and the person making the proposal, and would, if
           consummated, result in a transaction more favorable to ALZA's
           stockholders from a financial point of view than the transaction
           contemplated by the merger agreement,

       (2) ALZA's board of directors determines in good faith after consultation
           with outside legal counsel that the failure to take such action would
           result in the reasonable likelihood that ALZA's board of directors
           would breach its fiduciary duties to ALZA's stockholders under
           applicable law, and

       (3) prior to providing any information or data to any person in
           connection with an acquisition proposal by any such person, ALZA's
           board of directors will receive from such person an executed
           confidentiality agreement on terms substantially similar to those
           contained in the confidentiality agreement previously entered into
           between Abbott and ALZA in connection with their consideration of the
           merger.

                                       42
<PAGE>
FILINGS AND OTHER ACTIONS

    The merger agreement provides that ALZA and Abbott will cooperate with each
other and use their respective reasonable best efforts to obtain all consents,
registrations, approvals, permits and authorizations necessary or advisable to
be obtained from any third party or any governmental entity in order to complete
the merger and the other transactions contemplated by the merger agreement, and
to take or cause to be taken all actions, and do or cause to be done all things,
necessary, proper or advisable on their part under the merger agreement and
applicable laws to complete the merger and the other transactions contemplated
by the merger agreement, including:

    - preparing and filing all documentation to effect all necessary
      applications, notices, petitions, filings and other documents including,
      without limitation, filings under the Hart-Scott-Rodino Act;

    - instituting court actions and other proceedings necessary to obtain the
      approvals required to complete the merger or the other transactions
      contemplated by the merger agreement or defending or otherwise opposing
      all court actions and other proceedings instituted by a governmental
      entity or other person under foreign laws or otherwise for purposes of
      preventing the completion of the merger and the other transactions
      contemplated by the merger agreement; and

    - preparing prior to, and executing and delivering at, the closing of the
      merger, supplements to the agreements under which the 5% debentures, the
      5 1/4% debentures and the warrants are issued.

    The merger agreement also provides that:

    - ALZA will not, without Abbott's prior written consent, commit to any
      divestitures, licenses or hold separate or similar arrangements or allow
      its subsidiaries to commit to any divestitures, licenses or hold separate
      or similar arrangements, and ALZA will commit to, and will use reasonable
      best efforts to effect and will cause its subsidiaries to commit to and
      use reasonable best efforts to effect, any such divestitures, licenses or
      hold separate or similar arrangements as Abbott requests in order to
      obtain approval of the transactions contemplated by the merger agreement
      under applicable competition laws; and

    - except in some circumstances, neither Abbott nor any of its subsidiaries
      will be required to agree, with respect to Abbott or its subsidiaries or
      ALZA or its subsidiaries, to any divestitures, licenses or hold separate
      or similar arrangements in order to obtain approval of the merger under
      applicable competition laws if such divestitures, licenses or arrangements
      would reasonably be expected to have a material adverse effect on Abbott
      or ALZA or a material adverse effect on the expected benefits of the
      merger to Abbott.

    The merger agreement also provides that Abbott will reduce, if necessary,
the number of treasury shares attributable to Abbott such that the attribution
to Abbott of those treasury shares under the pooling-of-interests accounting
requirements will not prevent Abbott from accounting for the merger as a
pooling-of-interests.

CONDITIONS TO COMPLETION OF THE MERGER

    We will complete the merger only if the conditions set forth in the merger
agreement are satisfied or, in some cases, waived. These conditions include:

    - adoption of the merger agreement and approval of the merger by ALZA's
      stockholders;

    - no governmental entity of competent jurisdiction enacts, issues,
      promulgates, enforces or enters any law or order, whether temporary,
      preliminary or permanent, that is in effect and restrains,

                                       43
<PAGE>
      enjoins or otherwise prohibits completion of the merger or the other
      transactions contemplated by the merger agreement or permits completion of
      the merger or the other transactions contemplated by the merger agreement
      under applicable law but, except in some circumstances, subject to any
      divestitures, licenses or hold separate or similar arrangements if such
      divestiture, license or hold separate or similar arrangement would
      reasonably be expected to have a material adverse effect on Abbott or ALZA
      or a material adverse effect on the expected benefits of the merger to
      Abbott and no governmental entity institutes, and no authoritative source
      at a governmental entity threatens to institute, any proceeding seeking
      any of the above;

    - receipt of letters from Abbott's independent public accountants and ALZA's
      independent auditors stating their agreement with Abbott management's
      conclusion and ALZA management's conclusion, respectively, regarding the
      availability of pooling-of-interests accounting treatment for the merger;

    - receipt of legal opinions that the merger will be treated as a tax-free
      reorganization under the Internal Revenue Code;

    - the representations and warranties of ALZA, Abbott and their subsidiaries
      being true and correct, except where the failure to be true and correct is
      not reasonably expected to have a material adverse effect on ALZA, Abbott,
      their subsidiaries or, in some cases, the expected benefits of the merger
      to Abbott, as the case may be; and

    - the expiration or termination of the waiting period applicable to the
      completion of the merger under the Hart-Scott-Rodino Act; with respect to
      Abbott, without requiring any divestitures, licenses or hold separate or
      similar arrangements in order to obtain approval of the transactions
      contemplated by the merger agreement under applicable law if such
      divestitures, licenses or hold separate or similar arrangements would
      reasonably be expected to have a material adverse effect on Abbott or ALZA
      or a material adverse effect on the expected benefits of the merger to
      Abbott.

    At any time before the merger, to the extent legally allowed, the board of
directors of Abbott or ALZA may waive compliance with any of the conditions
contained in the merger agreement without the approval of Abbott shareholders or
ALZA stockholders. As of the date of this proxy statement/ prospectus, neither
Abbott nor ALZA expects that any condition will be waived.

    The approval of the merger by Abbott's shareholders is not required, and
Abbott is not seeking the approval of the merger from its shareholders.

TERMINATION OF THE MERGER AGREEMENT

    Abbott and ALZA can agree to terminate the merger agreement at any time
without completing the merger, even if ALZA's stockholders have approved it.

    Also, either Abbott or ALZA can, without the consent of the other, terminate
the merger agreement if:

    - the merger is not completed by December 31, 1999 or, under some
      circumstances relating primarily to obtaining governmental approvals of
      the merger, March 31, 2000, unless the failure to complete the merger is
      due to a violation of the merger agreement by the party that wants to
      terminate the merger agreement;

    - ALZA's stockholders do not adopt the merger agreement and do not approve
      the merger at the meeting;

    - a court or regulatory agency has prohibited the merger and no appeal is
      possible; or

                                       44
<PAGE>
    - the other party materially breaches the merger agreement, and cannot or
      does not correct the breach before December 31, 1999 or, under some
      circumstances relating to obtaining governmental approvals of the merger,
      March 31, 2000.

    In addition, ALZA can terminate the merger agreement before the meeting if
ALZA's board of directors receives and approves a superior proposal from another
party; provided that ALZA gives Abbott an opportunity to match or better the
other party's proposal.

    Finally, Abbott can terminate the merger agreement if ALZA's board of
directors:

    - withdraws, adversely modifies or changes its recommendation in favor of
      the merger agreement as a result of an acquisition proposal from another
      party;

    - fails to reconfirm its recommendation of the merger agreement within 15
      days after a written request by Abbott to do so in response to an
      acquisition proposal from another party; or

    - approves or recommends a superior proposal from another party.

TERMINATION FEE

    ALZA must pay Abbott a fee of $210 million in cash if the merger agreement
is terminated in the following circumstances:

    - if all of the following occur:

       (1) another party makes an acquisition proposal;

       (2) ALZA's board of directors does not withdraw, adversely modify or
           change its recommendation in favor of the merger agreement with
           Abbott;

       (3) ALZA's stockholders do not adopt the merger agreement with Abbott and
           do not approve the merger at the meeting;

       (4) either Abbott or ALZA terminates the merger agreement with Abbott;
           and

       (5) within 12 months of the termination of the merger agreement with
           Abbott, ALZA enters into an agreement with any other party to accept
           an acquisition proposal or an acquisition of ALZA is completed; or

    - if all of the following occur:

       (1) another party makes an acquisition proposal;

       (2) ALZA's board of directors withdraws, adversely modifies or changes
           its recommendation in favor of the merger agreement with Abbott;

       (3) ALZA's stockholders do not adopt the merger agreement with Abbott and
           do not approve the merger at the meeting; and

       (4) either Abbott or ALZA terminates the merger agreement with Abbott; or

    - if ALZA terminates the merger agreement before the meeting because ALZA's
      board of directors receives and approves a superior proposal from another
      party; or

    - if Abbott terminates the merger agreement because:

       (1) ALZA's board of directors withdraws, adversely modifies or changes
           its recommendation in favor of the merger agreement with Abbott as a
           result of an acquisition proposal from another party;

                                       45
<PAGE>
       (2) ALZA's board of directors fails to reconfirm its recommendation in
           favor of the merger agreement with Abbott within 15 days after a
           written request by Abbott to do so in response to an acquisition
           proposal;

       (3) ALZA's board of directors recommends a superior proposal from another
           party; or

       (4) there has been a material breach by ALZA of its obligation not to
           solicit, encourage or engage in negotiations regarding an alternative
           acquisition proposal.

EXPENSES

    Abbott and ALZA will each pay its own expenses in connection with the merger
and the related transactions, except that Abbott and ALZA will evenly divide the
costs and expenses that they incur in printing and mailing this proxy
statement/prospectus, the registration fees paid to the Securities and Exchange
Commission and other filing fees.

MODIFICATION OR AMENDMENT TO THE MERGER AGREEMENT

    Abbott and ALZA can modify or amend the merger agreement, whether before or
after the meeting, if they both agree to do so. Each can waive its right to
require the other to comply with the merger agreement, where the law allows.

REGULATORY REQUIREMENTS

    Under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and the rules
promulgated thereunder by the Federal Trade Commission, the merger cannot be
completed until notifications have been given and certain information has been
furnished to the Federal Trade Commission and the Antitrust Division of the
Department of Justice and specified waiting period requirements have been
satisfied. Abbott and ALZA filed notification and report forms under the
Hart-Scott-Rodino Act with the Federal Trade Commission and the Antitrust
Division on July 6, 1999. On August 5, 1999, the Federal Trade Commission made
second requests for additional information regarding the merger to which the
parties are responding. The waiting period requirement under the
Hart-Scott-Rodino Act will not expire until 20 days after both Abbott and ALZA
certify substantial compliance with the second requests, unless earlier
terminated by the Federal Trade Commission. It is possible that the waiting
period may not expire or be terminated prior to the date of the meeting.

    At any time before or after completion of the merger, the Antitrust Division
or the Federal Trade Commission, or any state, could take such action under the
antitrust laws as it deems necessary or desirable in the public interest,
including seeking to enjoin the completion of the merger or seeking divestiture
of particular assets of Abbott or ALZA. Private parties also may seek to take
legal action under the antitrust laws under certain circumstances. In addition,
non-United States governmental and regulatory authorities may seek to take
action under applicable antitrust laws. A challenge to the merger on antitrust
grounds may be made and, if such a challenge is made, Abbott and ALZA may not
prevail.

MATERIAL FEDERAL INCOME TAX CONSEQUENCES

    The following discussion summarizes the material federal income tax
consequences of the merger that are applicable to ALZA stockholders. This
summary is based on the Internal Revenue Code, applicable U.S. Treasury
Regulations, judicial authority, and administrative rulings and practice, all as
of the date of this proxy statement/prospectus, all of which are subject to
change, possibly with retroactive effect. This summary does not purport to be a
complete discussion of all U.S. federal income tax consequences of the merger.
The discussion below does not address any state, local or foreign tax
consequences of the merger. In addition, this discussion may not apply, in whole
or in part,

                                       46
<PAGE>
to particular stockholders such as individuals who hold options in respect of
ALZA common stock or who have acquired ALZA common stock under a compensatory or
other employment-related arrangement, insurance companies, tax-exempt
organizations, financial institutions or broker-dealers, persons who are neither
citizens nor residents of the United States, and persons who hold ALZA common
stock as part of a hedge, straddle or conversion transaction. The following
discussion assumes that ALZA common stock is held as a capital asset at the
effective time of the merger.

    ALZA STOCKHOLDERS ARE URGED TO CONSULT THEIR TAX ADVISORS AS TO THE
PARTICULAR TAX CONSEQUENCES OF THE MERGER TO THEM, INCLUDING THE APPLICABILITY
AND EFFECT OF ANY STATE, LOCAL OR FOREIGN LAWS, AND THE EFFECT OF POSSIBLE
CHANGES IN APPLICABLE TAX LAWS. THIS DISCUSSION DOES NOT APPLY TO ANCILLARY
TRANSACTIONS, IF ANY, BETWEEN THE PARTIES, SUCH AS ANY ADJUSTMENT OF
INTERCORPORATE INDEBTEDNESS.

GENERAL

    The obligations of ALZA and Abbott to consummate the merger are conditioned
upon the receipt by ALZA and Abbott of the opinions of Heller Ehrman White &
McAuliffe, counsel to ALZA, and Mayer, Brown & Platt, counsel to Abbott, that on
the basis of the facts, representations and assumptions set forth or referred to
therein, for U.S. federal income tax purposes, the merger will qualify as a
tax-free reorganization under Section 368(a) of the Internal Revenue Code, and
that each of Abbott, AC Merger Sub and ALZA will be a party to the
reorganization within the meaning of Section 368(b) of the Internal Revenue
Code. However, neither Abbott nor ALZA has requested or will request an advance
ruling from the Internal Revenue Service as to the tax consequences of the
merger, and there can be no assurance that the Internal Revenue Service will
agree with the conclusions set forth herein. Moreover, the tax opinions are
based upon certain facts, representations and assumptions set forth or referred
to therein and the continued accuracy and completeness of certain
representations made by Abbott, AC Merger Sub and ALZA, including
representations in certificates to be delivered to counsel at the effective time
by the management of each of Abbott and ALZA which, if incorrect in certain
material respects, would jeopardize the conclusions reached by counsel in their
opinions. The discussion below assumes that the merger qualifies as a
reorganization within the meaning of Section 368(a) of the Internal Revenue
Code.

TAX TREATMENT TO ALZA, ABBOTT AND AC MERGER SUB

    No gain or loss will be recognized by ALZA, Abbott or AC Merger Sub as a
result of the merger.

TAX TREATMENT TO HOLDERS OF ALZA COMMON STOCK

    Except for any cash received in lieu of fractional shares, an ALZA
stockholder will not recognize any gain or loss as a result of the receipt of
Abbott common shares pursuant to the merger. An ALZA stockholder's aggregate tax
basis for the Abbott common shares received pursuant to the merger, including
any fractional share interest for which cash is received, will equal such
stockholder's aggregate tax basis in shares of ALZA common stock held
immediately before the merger. An ALZA stockholder's holding period for the
Abbott common shares received pursuant to the merger, including any fractional
share interest for which cash is received, will include the period during which
the shares of ALZA common stock were held.

    A holder of ALZA common stock that receives cash in lieu of a fractional
Abbott common share in the merger will be treated as having received the cash in
redemption of the fractional share interest. The cash payment will be treated as
a distribution in payment of the fractional interest deemed redeemed under
Section 302 of the Internal Revenue Code. A holder of ALZA common stock who is
not (1) involved in directing corporate affairs of ALZA, (2) holds a minimal
interest in ALZA, and (3) does not directly own Abbott common shares and is not
considered to own indirectly shares of ALZA common stock or Abbott common shares
under the constructive ownership rules of Section 318

                                       47
<PAGE>
of the Internal Revenue Code, will recognize gain or loss on the deemed
redemption in an amount equal to the difference between the amount of cash
received and such holder's adjusted tax basis allocable to such fractional
share. Such gain or loss will be capital gain or loss if such holder's shares of
ALZA common stock are held as a capital asset at the closing of the merger. In
the case of other holders of ALZA common stock, Section 302 of the Internal
Revenue Code sets forth other tests, which, if met, would also result in similar
treatment of the holder. In the event, however, that none of these tests is met,
the cash payment would be taxable as a dividend.

    A successful Internal Revenue Service challenge to the reorganization status
of the merger would result in an ALZA stockholder recognizing gain or loss with
respect to each share of ALZA common stock surrendered equal to the difference
between the stockholder's basis in such share and the fair market value, as of
the effective time of the merger, of the Abbott common shares received in
exchange therefor. In such event, an ALZA stockholder's aggregate basis in the
Abbott common shares so received would equal its fair market value, and the
shareholder's holding period for such stock would begin the day after the
merger.

TAX TREATMENT TO HOLDERS OF CONVERTIBLE DEBENTURES

    No gain or loss should be recognized by holders of the 5% debentures or the
5 1/4% debentures upon the completion of the merger. Such debentures will become
convertible into Abbott common shares. However, upon subsequent conversion of a
debenture, a holder will recognize gain to the extent that the fair market value
of the Abbott common shares received, and/or any cash received in the case of
5 1/4% debentures, exceeds the holder's tax basis in the debenture. A holder of
a 5% debenture or 5 1/4% debenture would not have recognized gain upon the
conversion of the debenture into shares of ALZA common stock, although holders
of a 5 1/4% debenture would have recognized gain to the extent cash received in
lieu of shares of ALZA common stock exceeded the holder's tax basis in the
debenture.

TAX TREATMENT TO HOLDERS OF WARRANTS

    No gain or loss will be recognized by holders of warrants to purchase ALZA
common stock upon the conversion of such warrants into warrants to purchase
Abbott common shares. Warrant holders will not recognize gain or loss upon the
exercise of the warrants.

ANTICIPATED ACCOUNTING TREATMENT

    The merger is intended to qualify as a pooling-of-interests for accounting
purposes. Under this method of accounting, the recorded historical cost basis of
the assets and liabilities of Abbott and ALZA will be carried forward to the
operations of the combined company at their historical recorded amounts. Results
of operations of the combined company will include income of Abbott and ALZA for
the entire fiscal period in which the combination occurs, and the historical
results of operations of the separate companies for fiscal years prior to the
merger will be combined and reported as the results of operations of the
combined company. No adjustments have been made to the unaudited combined
condensed pro forma financial information of Abbott and ALZA to conform the
accounting policies of the combined company as the nature and amounts of such
adjustments are not expected to be significant.

    Completion of the merger is conditioned upon receipt by each of Abbott and
ALZA of a letter from its respective independent public accountants stating
that, in their respective opinions, they concur with the conclusions of the
management of Abbott and ALZA as to the appropriateness of pooling-of-interests
accounting treatment for the merger under APB No. 16, if completed in accordance
with the merger agreement. See "The Merger Agreement and the Merger--Conditions
to Completion of the Merger." However, some of the conditions to be met to
qualify for pooling-of-interests accounting

                                       48
<PAGE>
treatment cannot be fully assessed until the passage of specified periods of
time after the effective time of the merger, as certain of the conditions for
pooling-of-interests accounting treatment address transactions occurring within
such specified periods of time. Certain events, including certain transactions
with respect to Abbott common shares or ALZA common stock by affiliates of
Abbott and ALZA, respectively, could prevent the merger from qualifying as
pooling-of-interests for accounting purposes. For information concerning certain
restrictions to be imposed on the transferability of Abbott common shares to be
received by affiliates in order, among other things, to ensure the availability
of pooling-of-interests accounting treatment, see "The Merger Agreement and the
Merger--Resale Restrictions."

    If, after completion of the merger, events occur that cause the merger to be
deemed no longer to qualify for pooling-of-interests accounting treatment, the
purchase method of accounting would be applied. The purchase method of
accounting could have a material adverse effect on the reported operating
results of Abbott as compared to pooling-of-interests accounting treatment. See
"Risk Factors--Failure to qualify for pooling-of-interests accounting treatment
may impact reported operating results."

RESALE RESTRICTIONS

    This proxy statement/prospectus does not cover resales of the Abbott common
shares to be received by the stockholders of ALZA upon completion of the merger,
and no person is authorized to make any use of this proxy statement/prospectus
in connection with any such resale.

    All Abbott common shares received by ALZA stockholders in the merger will be
freely transferable, except that Abbott common shares received by persons who
are deemed to be "affiliates" (as such term is defined under the Securities Act
of 1933) of ALZA may be resold by them only in transactions permitted by the
resale provisions of Rule 145 (or Rule 144 in the case of such persons who
become affiliates of Abbott) promulgated under the Securities Act of 1933 or as
otherwise permitted under the Securities Act of 1933. Persons who may be deemed
to be affiliates of Abbott or ALZA generally include individuals or entities
that control, are controlled by, or are under common control with, such party
and may include certain officers and directors of Abbott or ALZA as well as
significant stockholders.

    Securities and Exchange Commission guidelines regarding qualification for
the use of the pooling-of-interests method of accounting also limit sales by
affiliates of the acquiring and acquired companies in a business combination.
Securities and Exchange Commission guidelines indicate further that the
pooling-of-interests method of accounting generally will not be challenged on
the basis of sales by affiliates of the acquiring or acquired company if they do
not dispose of any of the shares they own or shares they receive in connection
with a merger during the period beginning 30 days before the merger and ending
when financial results covering at least 30 days of combined operations have
been published. See "The Merger Agreement and the Merger--Anticipated Accounting
Treatment."

    Pursuant to the merger agreement, ALZA has caused each of its affiliates to
execute a written agreement restricting the disposition by such affiliate of the
Abbott common shares to be received by such affiliate in the merger. Pursuant to
the merger agreement, Abbott has caused each of its affiliates to execute a
written agreement restricting the disposition by such affiliate of any Abbott
common shares.

INTERESTS OF ALZA DIRECTORS AND OFFICERS IN THE MERGER THAT ARE DIFFERENT FROM
  YOUR INTERESTS

    In considering the recommendation of ALZA's board of directors with respect
to the merger, stockholders should be aware that some of the members of ALZA's
board of directors and some of ALZA's executive officers have interests in the
merger that are in addition to the interests of stockholders of ALZA generally
and that could potentially represent conflicts of interest.

                                       49
<PAGE>
    Some of the members of ALZA's board of directors and some of ALZA's
executive officers have personal interests in the merger that are different from
yours.

    - All outstanding options to purchase ALZA common stock, including those
      held by officers and directors of ALZA, will fully vest at the effective
      time of the merger and will become options to purchase Abbott common
      shares, subject to adjustment to reflect the exchange ratio. Absent the
      merger, these options would have vested according to the vesting schedule
      of each option agreement. Based upon the options outstanding as of August
      13, 1999, options held by ALZA's executive officers and directors relating
      to 1,051,735 shares of ALZA common stock will vest at the effective time
      of the merger.

    - Restrictions on 159,145 shares of restricted stock held by executive
      officers of ALZA, which shares constitute substantially all of the
      restricted stock held by executive officers of ALZA, will lapse at the
      effective time of the merger and the shares will be converted to Abbott
      common shares, subject to adjustment to reflect the exchange ratio.

    - The executive officers of ALZA will be entitled to severance payments and
      payments in connection with agreements not to compete with ALZA in the
      event of the termination of their employment following the merger.

    - Some current executive officers of ALZA will remain executive officers of
      ALZA after the merger.

    Each share of ALZA common stock held by ALZA's directors, executive officers
and their affiliates at the effective time of the merger will, upon completion
of the merger, along with all other ALZA common stock, be converted into the
right to receive 1.2 Abbott common shares.

    ALZA's board of directors was aware of these interests and considered them,
among other matters, when approving the merger.

    ALZA's directors, executive officers and their affiliates, including any
person who served as a director or executive officer of ALZA at any time during
1998, beneficially owned, as of August 13, 1999, less than 1% of ALZA's
outstanding common stock. Abbott's directors, executive officers and their
affiliates, including any person who served as a director or executive officer
of Abbott at any time during 1998, did not beneficially own, as of August 13,
1999, any shares of ALZA's common stock.

AMENDED EXECUTIVE AGREEMENTS

    On June 11, 1999, the Compensation and Benefits Committee of ALZA's board of
directors authorized and approved amendments to the Executive Agreements between
ALZA and each of its executive officers listed below, which amendments have been
entered into by ALZA and those executive officers. The Executive Agreements were
originally entered into in 1995 with individuals who were executive officers at
that time; identical agreements were later entered into with three additional
executive officers upon their promotion to that status. The purpose of the
Executive Agreements is to provide for severance benefits in the event of
termination of the executive's employment by ALZA or its successor, other than
for "cause," or by the executive for "good reason," in either case at or within
24 months following a "change in control" of ALZA, each as defined in the
Executive Agreements. The merger would constitute a change in control for
purposes of the Executive Agreements. The amendments to the Executive
Agreements:

    - provide for severance benefits of 2.5 times the executive's annual cash
      compensation (an increase from two times annual compensation in the
      original agreements);

    - provide for a gross-up, on a pro rata basis, for any excise tax that may
      be payable by the executive under Section 4999 of the Internal Revenue
      Code, and any income and employment

                                       50
<PAGE>
      taxes on the gross-up payment, with respect to severance payments that are
      not attributable to the acceleration of equity-based awards to the
      executive;

    - eliminate a provision in the original Executive Agreements that reduced
      the amount of severance benefits if the executive's employment was
      terminated more than one year, but less than two years, after a change in
      control;

    - eliminate a provision in the original Executive Agreements that provided
      for the executive to receive lump-sum cash payments for his or her stock
      options, which in the case of nonqualified stock options, was based on the
      higher of the stock price at the time of employment termination or the
      highest price paid in a "change in control" transaction, as defined in the
      Executive Agreements, and in the case of incentive stock options, was
      based on the stock price at the time of termination of employment; and

    - provide that the executives will enter into a noncompetition agreement for
      a period of one-year following the executive's termination for which the
      executive would receive four quarterly payments of $25,000.

<TABLE>
<CAPTION>
NAME                                                            TITLE
- -------------------------------------  -------------------------------------------------------
<S>                                    <C>
James Butler.........................  Group Vice President, ALZA Pharmaceuticals

Bruce Cozadd.........................  Senior Vice President and Chief Financial Officer

Harold Fethe.........................  Senior Vice President, Human Resources

Ronald Haak..........................  Senior Vice President, Technical Development

Robert Myers.........................  Senior Vice President, Commercial Development

Samuel Saks..........................  Senior Vice President, Medical Affairs

Peter Staple.........................  Senior Vice President and General Counsel

Janne Wissel.........................  Senior Vice President, Operations

James Young..........................  Group Vice President, ALZA Technologies
</TABLE>

    On June 21, 1999, following approval of the merger agreement, ALZA's board
of directors approved, and ALZA entered into, an Executive Agreement with Dr.
Mario that is substantially the same as the amended Executive Agreements
described above, except that Dr. Mario's Executive Agreement provides for
severance payments equal to three times his annual cash compensation, but not
less than $4.5 million, a 1999 bonus payment of $750,000 and a four-year
post-termination noncompetition agreement for which he would receive payments of
$31,250 per quarter. Dr. Mario had not previously been party to an Executive
Agreement.

INDEMNIFICATION AND INSURANCE

    The merger agreement provides that the certificate of incorporation and
bylaws of ALZA following the merger will contain, and provides that Abbott shall
cause ALZA following the merger to fulfill and honor, provisions with respect to
indemnification and exculpation that are substantially identical to those set
forth in the certificate of incorporation and bylaws of ALZA as of the date of
the merger agreement; and further provides that those provisions will not be
amended, repealed or otherwise modified for a period of six years after the
completion of the merger in any manner that would adversely affect the rights
thereunder of any person who is or was a director or officer of ALZA at any time
before the completion of the merger, or who serves or has in the past served at
the request of ALZA as a director, officer, trustee, partner, fiduciary,
employee or agent of another corporation, partnership, joint venture, trust,
pension or employee benefit plan or enterprise at any time before the completion
of the merger. In addition, for a period of six years after the completion of
the merger, Abbott will cause ALZA to maintain in effect, to the extent
available, directors' and officers' liability

                                       51
<PAGE>
insurance covering those persons who were covered on June 21, 1999 by the
directors' and officers' liability insurance policy maintained by ALZA on terms
comparable to the directors' and officers' liability insurance policy maintained
by ALZA on June 21, 1999, but Abbott is not required to expend in excess of 150%
per year of the annual premium paid by ALZA on June 21, 1999 for such coverage.
In the alternative, Abbott can obtain prepaid policies that provide such
directors and officers with coverage for an aggregate period of six years with
respect to claims arising from facts or events that occurred on or before the
effective time of the merger, for a premium not in excess of the aggregate of
the premiums described in the preceding sentence.

CO-PROMOTION AGREEMENTS

    Abbott and ALZA entered into two co-promotion agreements on June 21, 1999.
The co-promotion agreements provide that Abbott will assist ALZA in promoting
Ditropan XL-Registered Trademark- in the United States. The first co-promotion
agreement terminates 90 days after Abbott begins promoting Ditropan XL, but may
be extended by Abbott for one-month terms until April 30, 2000, unless
terminated earlier under the provisions of that agreement. The second
co-promotion agreement extends from 30 days after the date, if applicable, that
the merger agreement is terminated until June 30, 2004, unless the second co-
promotion agreement is terminated earlier under its terms. Each co-promotion
agreement provides that Abbott will make a specific number of presentations, or
sales calls, to medical personnel. If ALZA desires to increase the number of
sales calls that are made, ALZA must first give Abbott the right to make those
calls before entering into an agreement with another party.

    Under the first co-promotion agreement, ALZA will pay Abbott a total of
$3,150,000 as compensation for making 45,000 sales calls during the 90-day term
of that agreement, as long as net sales of Ditropan XL exceed $7,000,000 over
the period July 1, 1999 through the end of the 90-day term. If Abbott makes less
than 45,000 sales calls, ALZA will pay a reduced amount in proportion to the
number of sales calls Abbott made. If the first co-promotion agreement is
extended, ALZA will pay Abbott $1,050,000 if Abbott makes 15,000 sales calls in
each month that the agreement is extended and net sales of Ditropan XL exceed
$2,333,333 for that month.

    Under the second co-promotion agreement, ALZA will pay Abbott 15% of the net
sales of Ditropan XL as compensation for making 45,000 sales calls every three
months. If Abbott makes less than 45,000 sales calls in a three-month period,
ALZA will pay Abbott an amount in proportion to the number of sales calls Abbott
made in that three-month period, and pay the balance in the next three-month
period if Abbott makes up for a variance of 10% or less of the expected number
of sales calls. In addition, both co-promotion agreements provide that ALZA must
first offer to Abbott the right to co-promote and/or license
OROS-Registered Trademark- Methylphenidate in the United States before offering
that right to another party.

                     MARKET PRICES AND DIVIDEND INFORMATION

    Abbott common shares are principally traded on the New York Stock Exchange
under the symbol "ABT," and shares of ALZA common stock are traded on the New
York Stock Exchange under the symbol "AZA." Abbott common shares are also listed
on the Chicago Stock Exchange and the Pacific Exchange and are traded on the
Boston, Cincinnati and Philadelphia Exchanges. Outside the United States, Abbott
common shares are listed on the London Stock Exchange and the Swiss Stock
Exchange. The following table sets forth, for the periods indicated, the range
of high and low per share sales prices for Abbott common share and ALZA common
stock as reported on the New York Stock Exchange, as well as information
concerning quarterly cash dividends declared on such shares.

                                       52
<PAGE>

<TABLE>
<CAPTION>
                                                                                    SHARES OF ALZA
                                              ABBOTT COMMON SHARES                   COMMON STOCK
                                        --------------------------------   --------------------------------
                                         HIGH        LOW      DIVIDENDS     HIGH        LOW      DIVIDENDS
                                        -------    -------    ----------   -------    -------    ----------
<S>                                     <C>        <C>        <C>          <C>        <C>        <C>
1997
First Quarter.......................... $30 1/4    $24 7/8        $0.135   $31 3/8    $24 3/4           --
Second Quarter.........................  34 7/16    26 7/16        0.135    31 3/8     25 1/2           --
Third Quarter..........................  34 1/4     29 3/8         0.135    32 1/2     28 1/16          --
Fourth Quarter.........................  34 5/8     28 1/2         0.135    31 13/16   24 7/8           --

1998
First Quarter.......................... $39 7/16   $32 1/2        $0.15    $45 9/16   $30 7/8           --
Second Quarter.........................  42 11/16   34 7/8         0.15     52 7/8     40 1/2           --
Third Quarter..........................  45 11/16   36 5/8         0.15     45 1/2     33 3/4           --
Fourth Quarter.........................  50 1/16    39             0.15     54         38 9/16          --

1999
First Quarter.......................... $51 7/16   $43            $0.17    $55 3/4    $37 13/16         --
Second Quarter.........................  53 5/16    41 15/16       0.17     51 1/16    31               --
Third Quarter (through August 13,
  1999)................................  45 11/16   40 11/16          --    52 3/16    46 13/16         --
</TABLE>

    Abbott's market prices and dividends declared have been adjusted to reflect
a May 1998 2-for-1 stock split. ALZA has never paid cash dividends on its common
stock and will not pay dividends before the merger. After the merger, Abbott
expects to continue to pay a regular quarterly cash dividend. The payment of
dividends by Abbott in the future, however, will depend on business conditions,
Abbott's financial condition and earnings, and other factors.

                  COMPARISON OF RIGHTS OF ABBOTT SHAREHOLDERS
                             AND ALZA STOCKHOLDERS

    The rights of ALZA stockholders are currently governed by Delaware corporate
law and ALZA's certificate of incorporation and by-laws. Upon completion of the
merger, ALZA stockholders will become shareholders of Abbott and their rights as
Abbott shareholders will be governed by Illinois corporate law and Abbott's
articles of incorporation and by-laws. There are a number of differences between
the rights of Abbott shareholders and ALZA stockholders. The following is a
brief summary of the material differences between the rights of Abbott
shareholders and the rights of ALZA stockholders, and is qualified in its
entirety by reference to the relevant provisions of Delaware corporate law and
Illinois corporate law and by Abbott's articles of incorporation and by-laws and
ALZA's certificate of incorporation and by-laws, which charter documents are
incorporated by reference as exhibits to the registration statement of which
this proxy statement/prospectus is a part.

AUTHORIZED CAPITAL

    ABBOTT.  The total number of shares of all classes that Abbott is authorized
to issue is 2,401,000,000, of which 1,000,000 are preferred shares and
2,400,000,000 are common shares. On August 11, 1999, there were no preferred
shares outstanding and 1,521,425,665 Abbott common shares outstanding. Neither
under the merger agreement nor otherwise is Abbott prohibited from issuing
additional Abbott common shares or preferred shares.

    ALZA.  The total number of shares of all classes of stock that ALZA is
authorized to issue is 300,100,000, of which 100,000 are preferred stock and
300,000,000 are common stock. On August 11, 1999, there were no shares of
preferred stock outstanding and 101,686,193 shares of ALZA common stock
outstanding. ALZA's certificate of incorporation and by-laws do not prohibit
ALZA from issuing additional ALZA common stock or ALZA preferred stock. Under
the merger agreement, however,

                                       53
<PAGE>
ALZA is prohibited from issuing additional ALZA common stock or ALZA preferred
stock, except for ALZA common stock issued pursuant to options and other awards
outstanding as of June 21, 1999 under ALZA's stock plans or as is otherwise
permitted under the merger agreement.

VOTING RIGHTS

    ABBOTT.  The holders of Abbott common shares are entitled to one vote per
share on each matter submitted to a vote at a meeting of shareholders. Under
Illinois corporate law, Abbott is required to have cumulative voting unless its
articles of incorporation provide otherwise. Abbott's articles of incorporation
provide that each shareholder may cumulate votes in the election of directors
and give one candidate the number of votes equal to the number of directors
multiplied by the number of the shareholder's shares or to distribute those
cumulative votes in any proportion among the candidates.

    ALZA.  The holders of shares of ALZA common stock are entitled to one vote
per share on each matter submitted to a vote at a meeting of stockholders.
ALZA's certificate of incorporation does not provide for cumulative voting in
the election of directors. The absence of cumulative voting rights effectively
means that the holders of a majority of the shares voted at a meeting of
stockholders may, if they so choose, elect all directors to be selected at that
meeting, thereby precluding minority stockholder representation on ALZA's board
of directors.

BOARD OF DIRECTORS

    ABBOTT.  Abbott's by-laws provide that Abbott's entire board of directors is
elected each year.

    ALZA.  ALZA's by-laws provide that ALZA's board of directors is divided into
three classes of directors serving staggered three-year terms. As a result,
approximately one-third of ALZA's board of directors is elected each year.

NUMBER, ELECTION, VACANCY AND REMOVAL OF DIRECTORS

    ABBOTT.  Abbott's board of directors currently has 13 members. The number of
directors may be changed by a resolution adopted by Abbott's board of directors
and may also be changed by Abbott's shareholders under Illinois corporate law.
The term of each director expires at the next annual meeting of shareholders
following his or her election.

    Abbott's by-laws provide that vacancies and newly created directorships
shall be filled by a majority of directors then in office, even if less than a
quorum. According to Abbott's by-laws, not more than one-third of the directors
of Abbott may be selected to fill vacancies in this manner during any period
between shareholder meetings.

    Abbott's articles of incorporation do not address removal of directors. As
such, Illinois corporate law provides that the holders of a majority of the
outstanding shares entitled to vote at an election of directors may remove any
director, with or without cause, at a meeting of shareholders. However, if less
than the entire board of directors of Abbott is to be removed, no director may
be removed, with or without cause, if the votes cast against that director's
removal would be sufficient to elect that director if those votes were cumulated
at an election of the entire board of directors.

    ALZA.  ALZA's board of directors currently has eight members. The number of
directors may be changed by a resolution adopted by ALZA's board of directors.
Each director of ALZA serves until the annual meeting of stockholders in the
year in which his or her term expires and his or her successor is duly elected
and qualified.

    ALZA's by-laws provide that vacancies and newly created directorships shall
be filled by a majority of directors then in office, even if less than a quorum.

                                       54
<PAGE>
    ALZA's certificate of incorporation provides that any ALZA director may be
removed only for cause by the affirmative vote of the holders of a majority of
the shares then entitled to vote for the election of directors.

STOCKHOLDER ACTION BY WRITTEN CONSENT

    ABBOTT.  Under Illinois corporate law, unless otherwise provided in a
corporation's articles of incorporation, any action required to be taken by the
corporation's shareholders at a meeting of shareholders may be taken without a
meeting and without a vote if a consent in writing is signed by holders of
shares having at least the number of votes necessary at a shareholder meeting.
Abbott's articles of incorporation are silent on this matter so Abbott's
shareholders may act by written consent.

    ALZA.  Under Delaware corporate law, unless otherwise provided in a
corporation's certificate of incorporation, any action required or permitted to
be taken by the corporation's stockholders may be effected by less than
unanimous consent without prior notice and without a vote. However, ALZA's
certificate of incorporation and by-laws provide that any action required or
permitted to be taken by the stockholders of the corporation must be taken at a
duly called annual or special meeting of such holders and may not be taken by a
consent in writing by any such holders.

SPECIAL STOCKHOLDER MEETINGS

    ABBOTT.  Abbott's by-laws provide that special meetings of the shareholders
of the corporation may be called only by:

    - the board of directors;

    - the chairman of the board of directors;

    - the chief executive officer;

    - the president; or

    - the holders of not less than one-fifth of all outstanding shares entitled
      to vote on the matter for which the meeting is called.

    ALZA.  ALZA's certificate of incorporation and by-laws provide that special
meetings of the stockholders of the corporations may be called only by:

    - the board of directors;

    - the chairman of the board of directors; or

    - the president.

ADVANCE NOTICE PROVISIONS FOR STOCKHOLDER PROPOSALS OTHER THAN ELECTION OF
  DIRECTORS

    ABBOTT.  Abbott's by-laws provide that a shareholder must give advance
written notice to bring matters, other than nominations for election as a
director, before an annual meeting of shareholders. Abbott's by-laws provide
that a shareholder's notice must be delivered to, or mailed and received, at the
principal executive offices of Abbott:

    - not earlier than October 1 nor later than the first business day of
      January prior to the annual meeting; or

    - if the annual meeting is not in April and less than 65 days' notice or
      prior public disclosure of the date of an annual meeting is given or made
      to shareholders, a shareholder's notice must be received not later than
      the close of business on the fifteenth day following the date on which
      Abbott mailed its annual meeting notice or such public disclosure was
      made, whichever first occurs.

                                       55
<PAGE>
    Abbott's by-laws require that, to be in proper form, a shareholder's notice
must contain:

    - a brief description of the business the shareholder desires to bring
      before the annual meeting and the reasons for conducting the business at
      the annual meeting;

    - the shareholder's name and address;

    - the class and number of shares of capital stock that the shareholder
      beneficially owns; and

    - any material interest the shareholder has in the proposal.

    ALZA.  ALZA's by-laws provide that a stockholder must give advance written
notice to bring matters, other than nominations for election as a director,
before an annual meeting of stockholders. ALZA's by-laws provide that a written
stockholder's notice must be delivered to the Secretary of ALZA:

    - not less than 75 days prior to the first anniversary of the date on which
      ALZA first mailed its proxy materials for the preceding year's annual
      meeting of stockholders; or

    - if the date of the annual meeting is advanced more than 30 days prior to,
      or delayed by more than 30 days after, the anniversary of the preceding
      year's annual meeting, notice by the stockholder must be delivered not
      later than the later of:

          -- 90 days prior to the annual meeting; and

          -- the tenth day following the day on which ALZA makes the public
             announcement of the date of the meeting.

    ALZA's by-laws require that, to be in proper form, a stockholder's notice
must contain:

    - the stockholder's name and address;

    - any material interest the stockholder has in the proposal; and

    - any other information concerning the person making the proposal and the
      proposal itself that is required to be disclosed in solicitations for
      proxies for the proposal by the Securities and Exchange Commission rules.

ADVANCE NOTICE PROVISIONS FOR STOCKHOLDER NOMINATIONS OF DIRECTORS

    ABBOTT.  Abbott's by-laws also require advance notice from shareholders who
want to nominate candidates for election as directors. Abbott's by-laws provide
that a shareholder's notice must be delivered to or mailed and received at the
principal executive offices of Abbott:

    - not earlier than October 1 nor later than the first business day of
      January prior to the annual meeting; or

    - if the annual meeting is not in April and less than 65 days' notice or
      prior public disclosure of the date of an annual meeting is given or made
      to shareholders, a shareholder's notice must be received not later than
      the close of business on the fifteenth day following the day on which
      Abbott mailed its annual meeting notice or such public disclosure was
      made, whichever first occurs.

    Abbott's by-laws require that, to be in proper form, a shareholder's notice
must contain:

    - as to each person whom the shareholder proposes to nominate for election
      or re-election as a director:

          -- the nominee's name, age, business address and residence address;

          -- the nominee's principal occupation or employment;

                                       56
<PAGE>
          -- the class and number of shares of capital stock that the nominee
             beneficially owns;

          -- the nominee's signed consent to serve as a director of the
             corporation if elected;

          -- any other information relating to the nominee that is required to
             be disclosed in solicitations for proxies for election of directors
             pursuant to Securities and Exchange Commission rules; and

          -- any other information as Abbott may reasonably require to determine
             the nominee's eligibility to serve as a director; and

    - as to the shareholder giving the notice:

          -- the shareholder's name and record address; and

          -- the class and number of shares of capital stock that the
             shareholder beneficially owns.

    ALZA.  ALZA's by-laws also require advance notice from stockholders who want
to nominate candidates for election as directors. ALZA's by-laws provide that a
written stockholder's notice must be delivered to the Secretary of ALZA:

    - not less than 75 days prior to the first anniversary of the date on which
      ALZA first mailed its proxy materials for the preceding year's annual
      meeting of stockholders; or

    - if the date of the annual meeting is advanced more than 30 days prior to,
      or delayed by more than 30 days after, the anniversary of the preceding
      year's annual meeting, notice by the stockholder must be delivered not
      later than the later of:

          -- 90 days prior to the annual meeting; and

          -- the tenth day following the day on which ALZA makes the public
             announcement of the date of the meeting.

    ALZA's by-laws require that, to be in proper form, a stockholder's notice
must contain:

    - the name and address of the nominee;

    - the name and address of the stockholder giving notice;

    - any other information relating to the nominee or the stockholder giving
      notice that is required to be disclosed in solicitations for proxies for
      election of directors pursuant to the Securities and Exchange Commission
      rules; and

    - the duly executed written consent of the nominee to serve as director if
      elected.

TRANSACTIONS WITH INTERESTED STOCKHOLDERS

    ABBOTT.  Abbott is governed by the provisions of section 11.75 of Illinois
corporate law. Section 11.75 provides that a merger, consolidation or
disposition of assets or securities involving an "interested shareholder,"
defined as a person beneficially owning 15% or more of a corporation's voting
stock, would be prohibited for three years following the date such person became
an interested shareholder unless:

    - before such person became an interested shareholder, the board of
      directors of the corporation approved the transaction in which the
      interested shareholder became an interested shareholder;

    - upon consummation of the transaction that resulted in the interested
      shareholder becoming an interested shareholder, the interested shareholder
      owned at least 85% of the voting stock of the corporation outstanding at
      the time the transaction commenced; or

                                       57
<PAGE>
    - following the transaction in which such person became an interested
      shareholder, the transaction is approved by the board of directors and
      authorized at a meeting of shareholders by the affirmative vote of the
      holders of two-thirds of the outstanding voting stock not owned by the
      interested shareholder.

    Section 7.85 of Illinois corporate law provides an extra protection for
Illinois interested shareholder transactions by requiring any business
combination to be approved by at least 80% of the combined voting power of
outstanding shares of all classes and two-thirds of the disinterested shares.
The higher voting requirements of this provision do not apply to a transaction
if:

    - two-thirds of the disinterested directors approve the transactions; or

    - certain price and procedure requirements of section 7.85 are satisfied.

    Sections 7.85 and 11.75 only apply to Illinois corporations which have a
class of voting shares that (1) is listed on a national securities exchange, (2)
is quoted on an interdealer quotation system such as NASDAQ or (3) is held of
record by more than 2,000 shareholders. An Illinois corporation may elect not to
be governed by sections 7.85 and 11.75 in its original articles of incorporation
or an amendment thereto or in its bylaws, which amendment must be approved by a
majority shareholder vote and may not be further amended by the board of
directors. Abbott is governed by sections 7.85 and 11.75 of Illinois corporate
law.

    ALZA.  Under section 203 of Delaware corporate law, a Delaware corporation
is also prohibited from engaging in a business combination with an interested
stockholder for a period of three years following the date such person became an
interested stockholder unless certain conditions are satisfied. The definition
of "interested stockholder" and the conditions to be satisfied are the same as
under section 11.75 of Illinois corporate law.

    In addition to the provisions required by Delaware corporate law, ALZA's
certificate of incorporation sets forth an 80% stockholder approval requirement
for mergers and other similar transactions involving substantial stockholders.
ALZA's certificate of incorporation generally prohibits:

    - a merger or consolidation;

    - a sale, exchange, lease or other disposition of assets having a value
      equal to 30% or more of ALZA's assets;

    - an issuance of securities of ALZA or a subsidiary; or

    - a recapitalization of ALZA's securities

if that transaction involves a "related person," defined as a beneficial owner
of 20% or more of ALZA's outstanding voting stock, unless the business
combination:

    - is approved by a majority of ALZA's continuing directors;

    - is between ALZA and a wholly owned subsidiary of ALZA; or

    - satisfies certain fair price criteria and procedural requirements designed
      to ensure that ALZA's stockholders receive a fair price for their shares.

AMENDMENTS TO CERTIFICATES OF INCORPORATION AND BY-LAWS

    ABBOTT.  Under Illinois corporate law, amendments to a corporation's
articles of incorporation must be adopted by the action of the board of
directors and approved by two-thirds of all votes entitled to vote on that
amendment. Additionally, if any class or series of shares is entitled to vote as
a class, the proposed amendment must be approved by at least two-thirds of the
votes of the shares of each class or series of shares entitled to vote as a
class. Illinois corporate law permits a corporation to

                                       58
<PAGE>
decrease the voting requirement. Abbott's articles of incorporation do not
provide for a decrease of the voting requirement. Illinois corporate law also
permits certain non-economic changes to be made to a corporation's articles of
incorporation with the approval of a majority of the entire board of directors,
without shareholder approval.

    Abbott's by-laws provide that the by-laws may be made, altered, amended or
repealed by the shareholders by a majority vote of the outstanding voting shares
or Abbott's board of directors by a majority vote of the directors.

    ALZA.  Under Delaware corporate law, amendments to a corporation's
certificate of incorporation must be approved by the board of directors, the
affirmative vote of the holders of a majority of the outstanding shares entitled
to vote for the amendment, and the affirmative vote of the holders of a majority
of the outstanding stock of each class entitled to vote for the amendment,
unless a higher vote is required by the corporation's certificate of
incorporation. ALZA's certificate of incorporation does provide that a higher
vote is required for amendments relating to (1) business combinations and (2)
number, classification, term of office and the filling of vacancies on ALZA's
board of directors.

    ALZA's by-laws provide that the by-laws may be amended or repealed or new
by-laws may be adopted by the stockholders or the board of directors by a
majority vote of the outstanding voting shares or directors, except that
amendments relating to (1) business combinations and (2) number, classification,
term of office and the filling of vacancies on ALZA's board of directors may
only be amended as described below.

    To amend the provisions of ALZA's certificate of incorporation and by-laws
relating to business combinations, ALZA's certificate of incorporation and
by-laws require the approval of:

    - 80% of ALZA's board of directors;

    - a majority of the continuing directors; and

    - 80% of the outstanding voting stock,

unless the amendment of that provision is recommended to the stockholders by a
resolution adopted by a majority of ALZA's board of directors and 80% of the
continuing directors.

    To amend the provisions of ALZA's certificate of incorporation and by-laws
relating to the number, classification, term of office and the filling of
vacancies on ALZA's board of directors, ALZA's certificate of incorporation and
by-laws also require the approval of:

    - 75% of ALZA's board of directors; and

    - 80% of the voting stock of ALZA entitled to vote in an election of
      directors.

MERGER OR SALE OF ASSETS

    ABBOTT.  Abbott's articles of incorporation contain no provisions governing
a merger or the sale of all or substantially all of its property and assets, but
Illinois corporate law requires such transactions to be approved by holders of
two-thirds of the outstanding stock entitled to vote thereon.

    ALZA.  ALZA's certificate of incorporation contains no provisions governing
a merger or the sale of all or substantially all of its property and assets, but
Delaware corporate law, unlike Illinois corporate law, requires such
transactions to be approved by holders of a simple majority of the outstanding
stock entitled to vote thereon.

                                       59
<PAGE>
INDEMNIFICATION

    ABBOTT.  Section 8.75 of Illinois corporate law provides that a corporation
may indemnify any person who is a party or is threatened to be made a party to
any action, suit or proceeding brought or threatened by reason of the fact that
he or she is or was a director, officer, employee or agent of the corporation,
or is or was serving as such with respect to another corporation at the request
of the corporation, if that person acted in good faith and in a manner that he
or she reasonably believed to be in or not opposed to the best interests of the
corporation and, with respect to any criminal action, had no reasonable cause to
believe his or her actions were unlawful.

    Abbott's articles of incorporation provide that any person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, because he or she is or was a director,
officer, employee or agent of Abbott, or is or was serving at the request of
Abbott as a director, officer, employee or agent of another corporation or other
enterprise, must, in the case of persons who are or were directors or officers
of Abbott, and may, as to other persons, be indemnified (and Abbott must, in the
case of persons who are or were directors or officers of Abbott, and may, as to
other persons, advance expenses incurred in defending those actions, suits or
proceedings) to the fullest extent permitted by law.

    ALZA.  Section 145 of Delaware corporate law also permits a corporation to
indemnify officers, directors, employees and agents for certain actions. The
provisions of section 145 of Delaware corporate law are substantially the same
as the provisions of section 8.75 of Illinois corporate law with respect to such
indemnification.

    ALZA's certificate of incorporation and by-laws provide that any person who
was or is made a party or is threatened to be made a party to any action, suit
or proceeding because he or she is or was a director, officer or employee of
ALZA, or is or was serving at the request of ALZA as a director, officer,
employee, agent or trustee of another corporation or other enterprise, must be
indemnified and held harmless by ALZA against all expense reasonably incurred or
suffered by such person in connection therewith if that person acted in good
faith and in a manner he or she reasonably believed to be in, or not opposed to,
the best interests of ALZA. ALZA must indemnify any such person seeking
indemnification in connection with a proceeding initiated by that person only if
the proceeding was authorized by ALZA's board of directors. ALZA's by-laws
further provide that the right to indemnification includes the right to have
ALZA pay the expenses incurred in defending any such proceeding in advance of
its final disposition if that director or officer undertakes to repay all
amounts so advanced if ultimately it is determined that such director or officer
is not entitled to be indemnified.

DIVIDENDS

    ABBOTT.  Under Illinois corporate law, no distribution to shareholders may
be made if, after giving it effect:

    - the corporation would be insolvent; or

    - the net assets of the corporation would be less than zero or less than the
      maximum amount payable at the time of distribution to shareholders having
      preferential rights in liquidation if the corporation were then to be
      liquidated.

    In addition, Abbott's articles of incorporation provide that before any
dividends on the common shares or on any other class or classes of shares
ranking junior to the preferred shares with respect to payment of dividends can
be paid or declared or set apart for payment, the holders of preferred shares
are entitled to receive when and as declared by Abbott's board of directors,
cumulative cash dividends, out of any funds legally available for the
declaration of dividends. No dividends will be paid on any series of the
preferred shares in respect of any dividend period unless all cumulative
dividends accrued prior to that dividend period with respect to all preferred
shares of each other series have been paid or

                                       60
<PAGE>
declared and set aside for payment. Holders of Abbott's common shares are
entitled to dividends if, as and when Abbott's board of directors declares
dividends payable out of funds legally available for distribution. Under the
merger agreement, Abbott is prohibited from declaring, setting aside or paying
any dividend payable in cash, stock, other than Abbott common shares, or
property in respect of any capital stock, except for regular quarterly cash
dividends or a dividend that would be received by ALZA's stockholders on an
equivalent basis per Abbott common share after the effective time of the merger.

    ALZA.  Under Delaware corporate law, a corporation's board of directors may
declare and pay dividends upon the shares of its capital stock either:

    - out of its surplus; or

    - in case there is no surplus, out of its net profits for the fiscal year in
      which the dividend is declared and/or the preceding fiscal year.

ALZA's certificate of incorporation does not provide any additional provisions
relating to the payment of dividends. Under the merger agreement, ALZA is
prohibited from declaring, setting aside or paying any dividend payable in cash,
stock or property in respect of any capital stock.

LIMITATIONS ON DIRECTOR'S LIABILITY

    ABBOTT.  Abbott's articles of incorporation and Illinois corporate law each
provide that a director shall not be personally liable to the corporation or its
stockholders for monetary damages arising out of the director's breach of his or
her fiduciary duty as a director, except:

    - for any breach of a director's duty of loyalty to the corporation or its
      stockholders;

    - for acts or omissions not in good faith or that involve intentional
      misconduct or a knowing violation of law;

    - for unlawful payment of dividends or other unlawful acts after the
      dissolution of the corporation; or

    - for any transaction from which the director derived an improper benefit.

The provision does not eliminate or limit the liability of a director for any
act or omission occurring before the date the provision became effective.

    ALZA.  ALZA's certificate of incorporation and Delaware corporate law each
provide a provision limiting the liability of a director that is substantially
the same as the provision limiting the liability of a director in Abbott's
articles of incorporation and Illinois corporate law.

DISSENTERS' OR APPRAISAL RIGHTS

    ABBOTT.  Under Illinois corporate law, shareholders are entitled to dissent
from and obtain payment for his or her shares in the event of any of the
following corporate actions:

    - mergers and share exchanges if shareholder authorization is required for
      the transaction by Illinois corporate law or the corporation's articles of
      incorporation;

    - the sale, lease or exchange of all or substantially all of the corporate
      assets; or

    - amendments to the articles of incorporation that materially and adversely
      affect rights in respect of a dissenter's shares.

    ALZA.  Under Delaware corporate law, appraisal rights may be available in
connection with a statutory merger or consolidation in certain specific
situations. Appraisal rights are not available when a

                                       61
<PAGE>
corporation is to be the surviving corporation and no vote of its stockholders
is required to approve the merger or consolidation. In addition, no appraisal
rights are available to holders or shares of any class of stock which is either:
(1) listed on a national securities exchange or designated as a national market
system security on an interdealer quotation system by the National Association
of Securities Dealers, Inc.; or (2) held of record by more than 2,000
stockholders, unless such stockholders are required by the terms of the merger
or consolidation to accept anything other than:

    - shares of the surviving corporation;

    - shares of stock that are listed on a national securities exchange or
      designated as a national market system security on an interdealer
      quotation system by the National Association of Securities Dealers, Inc.
      or held of record by more than 2,000 stockholders;

    - cash in lieu of fractional shares; or

    - any combination of the foregoing.

Stockholders do not have dissenters' appraisal rights with respect to any
transaction involving the sale, lease or exchange of all or substantially all of
the assets of the corporation.

    Stockholders who perfect their appraisal rights are entitled to receive cash
from the corporation equal to the value of their shares as established by
judicial appraisal. Corporations may enlarge these statutory rights by including
in their certificate of incorporation a provision allowing the appraisal rights
in any merger or consolidation in which the corporation is a constituent
corporation. ALZA's certificate of incorporation does not enlarge these rights.

                             ADDITIONAL INFORMATION

DEADLINE FOR ALZA STOCKHOLDER PROPOSALS AND ABBOTT SHAREHOLDER PROPOSALS

ALZA'S 2000 ANNUAL MEETING

    If the merger is not completed, ALZA will hold an annual meeting in the year
2000. If such meeting is held, ALZA stockholders must deliver any proposals
which they intend to present at such meeting to ALZA no later than December 6,
1999.

    Separate from the requirements described above concerning the notice
required for a proposal to be included in the proxy statement distributed by
ALZA, ALZA's by-laws also provide for certain advance notice of nominations by
stockholders for election of stockholder nominees as directors at an annual
meeting, and proposals for the inclusion of other business at an annual meeting
of stockholders, even if such nominations or proposals are not to be included in
the ALZA proxy statement. In addition to meeting other requirements specified in
ALZA's by-laws, the required notice by the stockholder for the annual meeting in
the year 2000 must be received in writing by the Secretary of ALZA no later than
January 16, 2000; provided, however, that if the date of the annual meeting to
be held in the year 2000 is advanced more than 30 days prior to, or delayed by
more than 30 days after, the anniversary of the 1999 annual meeting, the
stockholder's notice must be received no later than the close of business on the
later of (1) the 90th day prior to such annual meeting or (2) the 10th day
following the day on which public announcement of the meeting is first made.

ABBOTT'S 2000 ANNUAL MEETING

    Shareholder proposals for presentation at Abbott's 2000 annual meeting must
be received by Abbott no later than November 9, 1999 and must otherwise comply
with the applicable requirements of the Securities and Exchange Commission to be
considered for inclusion in the proxy statement and proxy for Abbott's 2000
meeting.

                                       62
<PAGE>
    An Abbott shareholder may recommend persons as potential nominees for
director by submitting the names of such persons in writing to the chairman of
the nominations and board affairs committee or the Secretary of Abbott.
Recommendations should be accompanied by a statement of qualifications and
confirmation of the person's willingness to serve.

    An Abbott shareholder may directly nominate persons for director only by
complying with the following procedure: the shareholder must submit the names of
such persons in writing to the Secretary of Abbott not earlier than the October
1 nor later than the first business day of January prior to the date of the
annual meeting. The nominations must be accompanied by a statement setting forth
the name, age, business address, residence address, principal occupation,
qualifications, and number of Abbott common shares owned by the nominee and the
name, record address, and number of Abbott common shares owned by the
shareholder making the nomination. An Abbott shareholder may properly bring
business before the annual meeting only by complying with the following
procedure: the shareholder must submit to the Secretary of Abbott, not earlier
than the October 1 nor later than the first business day of January prior to the
date of the annual meeting, a written statement describing the business to be
discussed, the reasons for conducting such business at the annual meeting, the
name, record address, and number of Abbott common shares owned by the
shareholder making the submission, and a description of any material interest of
the shareholder in such business.

LEGAL MATTERS

    The validity of the securities to be issued in the merger and the federal
income tax consequences of the merger to Abbott will be passed upon for Abbott
by Mayer, Brown & Platt, Chicago, Illinois. The support for the discussion set
forth under "The Merger Agreement and the Merger--Material Federal Income Tax
Consequences" in this proxy statement/prospectus and the federal income tax
consequences of the merger to ALZA and its stockholders will be passed upon for
ALZA by Heller Ehrman White & McAuliffe, Palo Alto, California.

EXPERTS

    Arthur Andersen LLP, independent public accountants, have audited Abbott's
consolidated financial statements and schedules included in the Annual Report on
Form 10-K for the year ended December 31, 1998, as indicated in their reports,
which is incorporated by reference in this registration statement. The
consolidated financial statements and schedules are incorporated by reference in
reliance on Arthur Andersen LLP's report, which is given on their authority as
experts in accounting and auditing.

    Ernst & Young LLP, independent auditors, have audited ALZA's consolidated
financial statements and schedule included in ALZA's Annual Report on Form 10-K
for the year ended December 31, 1998, as set forth in their report, which is
incorporated by reference in this proxy statement/prospectus. ALZA's
consolidated financial statements and schedule are incorporated by reference in
reliance on Ernst & Young's report, given on their authority as experts in
accounting and auditing. Ernst & Young have audited ALZA's restated consolidated
financial statements and schedule to reflect the combined results of ALZA and
SEQUUS upon completion of the merger which was accounted for as a pooling-
of-interests, included in ALZA's Current Report on Form 8-K filed with the
Securities and Exchange Commission on May 12, 1999, as set forth in their
report, which is incorporated by reference in this proxy statement/prospectus.
ALZA's restated consolidated financial statements and schedules are incorporated
by reference in reliance on Ernst & Young's report, given on their authority as
experts in accounting and auditing.

                                       63
<PAGE>
WHERE YOU CAN FIND MORE INFORMATION

    Abbott has filed with the Securities and Exchange Commission a registration
statement under the Securities Act of 1933 that registers the distribution of
the Abbott common shares to be issued to ALZA stockholders in connection with
the merger. The registration statement, including the attached exhibits and
schedules, contains additional relevant information about Abbott and Abbott
common shares. The rules and regulations of the Securities and Exchange
Commission allow Abbott and ALZA to omit certain information included in the
registration statement from this proxy statement/prospectus.

    In addition, Abbott and ALZA file reports, proxy statements and other
information with the Securities and Exchange Commission under the Securities
Exchange Act of 1934. You may read and copy this information at the following
locations of the Securities and Exchange Commission:

<TABLE>
<CAPTION>
<S>                                <C>                                <C>
Public Reference Room              New York Regional Office           Chicago Regional Office
450 Fifth Street, N.W.             7 World Trade Center               Citicorp Center
Room 1024                          Suite 1300                         500 West Madison Street
Washington, D.C. 20549             New York, New York 10048           Suite 1400
1-800-SEC-0330                                                        Chicago, Illinois 60661-2511
</TABLE>

    You may also obtain copies of this information by mail from the Public
Reference Section of the Securities and Exchange Commission, 450 Fifth Street,
N.W., Room 1024, Washington, D.C. 20549, at prescribed rates.

    The Securities and Exchange Commission also maintains an Internet world wide
web site that contains reports, proxy statements and other information about
issuers, like Abbott and ALZA, that file electronically with the Securities and
Exchange Commission. The address of that site is http://www.sec.gov.

    You can also inspect reports, proxy statements and other information about
Abbott and ALZA at the offices of the New York Stock Exchange, 20 Broad Street,
New York, New York 10005.

    The Securities and Exchange Commission allows Abbott and ALZA to
"incorporate by reference" information into this proxy statement/prospectus.
This means that the companies can disclose important information to you by
referring you to another document filed separately with the Securities and
Exchange Commission. The information incorporated by reference is considered to
be a part of this proxy statement/prospectus, except for any information that is
superseded by information that is included directly in this document.

                                       64
<PAGE>
    This proxy statement/prospectus incorporates by reference the documents
listed below that Abbott and ALZA have previously filed with the Securities and
Exchange Commission. They contain important information about Abbott and ALZA
and their financial condition.

<TABLE>
<CAPTION>
ABBOTT'S FILINGS WITH THE COMMISSION                                               PERIOD
- --------------------------------------------------------  --------------------------------------------------------
<S>                                                       <C>
Annual Report on Form 10-K..............................  Year ended December 31, 1998

Quarterly Report on Form 10-Q...........................  Quarters ended:

                                                          - March 31, 1999

                                                          - June 30, 1999

Current Report on Form 8-K..............................  Filed on June 30, 1999
</TABLE>

<TABLE>
<S>                                            <C>
The description of Abbott common shares set
  forth in Abbott's registration statement
  filed on Form S-3 on July 23, 1999,
  including any amendment or report filed
  with the Securities and Exchange Commission
  for the purpose of updating such
  description
</TABLE>

<TABLE>
<CAPTION>
ALZA'S FILINGS WITH THE COMMISSION                                                 PERIOD
- --------------------------------------------------------  --------------------------------------------------------
<S>                                                       <C>
Annual Report on Form 10-K..............................  Year ended December 31, 1998, as amended by the form
                                                            10-K/A filed April 19, 1999

Quarterly Report on Form 10-Q...........................  Quarters ended:

                                                          - March 31, 1999

                                                          - June 30, 1999

Current Reports on Form 8-K.............................  Filed on:

                                                          - March 16, 1999

                                                          - May 12, 1999

                                                          - June 25, 1999

The description of ALZA's capital stock set forth in
  ALZA's registration statement on Form 8-A filed on May
  14, 1992, including any amendment or report filed with
  the Securities and Exchange Commission for the purpose
  of updating such description
</TABLE>

    Abbott and ALZA incorporate by reference additional documents that either
company may file with the Securities and Exchange Commission between the date of
this proxy statement/prospectus and the date of the meeting. These documents
include periodic reports, such as Annual Reports on Form 10-K, Quarterly Reports
on Form 10-Q and Current Reports on Form 8-K, as well as proxy statements.

    Abbott has supplied all information contained or incorporated by reference
in this proxy statement/prospectus relating to Abbott, and ALZA has supplied all
such information relating to ALZA.

                                       65
<PAGE>
    You can obtain any of the documents incorporated by reference in this
document through Abbott and ALZA, as the case may be, or from the Securities and
Exchange Commission through its web site at the address described above.
Documents incorporated by reference are available from the companies without
charge, excluding any exhibits to those documents unless the exhibit is
specifically incorporated by reference as an exhibit in this proxy
statement/prospectus. You can obtain documents incorporated by reference in this
proxy statement/prospectus by requesting them in writing or by telephone from
the appropriate company at the following addresses:

<TABLE>
<CAPTION>
               ABBOTT                                 ALZA
- ------------------------------------  ------------------------------------
<S>                                   <C>
          Jose M. de Lasa                       Peter D. Staple
  Senior Vice President, Secretary           Senior Vice President
        and General Counsel                   and General Counsel
        Abbott Laboratories                     ALZA Corporation
       Dept. 364; Bldg. AP6D                   950 Page Mill Road
        100 Abbott Park Road                     P.O. Box 10950
  Abbott Park, Illinois 60064-6020      Palo Alto, California 94303-0802
      Telephone (847) 937-8905              Telephone (650) 494-5000
</TABLE>

    If you would like to request documents, please do so by, September 14, 1999
to receive them before the meeting. If you request any incorporated documents,
we will mail them to you by first class mail, or another equally prompt means,
within one business day after we receive your request.

    Neither Abbott nor ALZA has authorized anyone to give any information or
make any representation about the merger, Abbott or ALZA that is different from,
or in addition to, that contained in this proxy statement/prospectus or in any
of the materials that we have incorporated into this document. Therefore, if
anyone does give you information of this sort, you should not rely on it. If you
are in a jurisdiction where offers to exchange or sell, or solicitations of
offers to exchange or purchase, the securities offered by this document or the
solicitation of proxies is unlawful, or if you are a person to whom it is
unlawful to direct these types of activities, then the offer presented in this
document does not extend to you. The information contained in this document
speaks only as of the date of this document unless the information specifically
indicates that another date applies.

FORWARD-LOOKING STATEMENTS

    This proxy statement/prospectus, including information included or
incorporated by reference herein, contains certain forward-looking statements
with respect to the financial condition, results of operations, plans,
objectives, future performance and business of each of Abbott and ALZA, as well
as certain information relating to the merger, including, without limitation,
statements preceded by, followed by or that include the words "believes,"
"expects," "anticipates," "estimates" or similar expressions. These
forward-looking statements involve certain risks and uncertainties. For those
statements, Abbott and ALZA claim the protection of the safe harbor for
forward-looking statements contained in the Private Securities Litigation Reform
Act of 1995. Actual results may differ materially from those contemplated by
such forward-looking statements due to, among others, the factors described
under "Risk Factors" in this proxy statement/prospectus and the following
factors:

    - competitive pressures among health care products manufacturers and service
      providers may increase significantly;

    - costs or difficulties related to the integration of the business of Abbott
      and ALZA may be greater than expected;

    - general economic or business conditions, either internationally,
      nationally or in the states in which Abbott or ALZA is doing business, may
      be less favorable than expected resulting in, among other things, a
      reduced demand for health care products and services;

                                       66
<PAGE>
    - legislative or regulatory changes may adversely affect the business in
      which Abbott and ALZA are engaged;

    - technological changes, including "Year 2000" data systems compliance
      issues, may be more difficult or expensive than anticipated; and

    - changes may occur in the securities markets.

                                       67
<PAGE>
                                                                         ANNEX A

                          AGREEMENT AND PLAN OF MERGER
                                     AMONG
                               ALZA CORPORATION,
                              ABBOTT LABORATORIES
                                      AND
                               AC MERGER SUB INC.
                           DATED AS OF JUNE 21, 1999

                                      A-1
<PAGE>
                               TABLE OF CONTENTS
                                   ARTICLE I.
                      THE MERGER; CLOSING; EFFECTIVE TIME

<TABLE>
<S>        <C>                                                                              <C>
1.1.       The Merger.....................................................................        A-7
1.2.       Closing........................................................................        A-7
1.3.       Effective Time.................................................................        A-7
</TABLE>

                                  ARTICLE II.
      CERTIFICATE OF INCORPORATION AND BYLAWS OF THE SURVIVING CORPORATION

<TABLE>
<S>        <C>                                                                              <C>
2.1.       The Certificate of Incorporation...............................................        A-8
2.2.       The Bylaws.....................................................................        A-8
</TABLE>

                                  ARTICLE III.
                       OFFICERS, DIRECTORS AND MANAGEMENT

<TABLE>
<S>        <C>                                                                              <C>
3.1.       Directors of Surviving Corporation.............................................        A-8
3.2.       Officers of Surviving Corporation..............................................        A-8
</TABLE>

                                  ARTICLE IV.
        EFFECT OF THE MERGER ON CAPITAL STOCK; EXCHANGE OF CERTIFICATES

<TABLE>
<S>        <C>                                                                              <C>
4.1.       Effect on Capital Stock........................................................        A-8
4.2.       Exchange of Certificates for Shares............................................        A-9
4.3.       Dissenters' Rights.............................................................       A-11
4.4.       Adjustments to Prevent Dilution................................................       A-11
4.5.       Convertible Debentures; Warrants...............................................       A-11
</TABLE>

                                   ARTICLE V.
                         REPRESENTATIONS AND WARRANTIES

<TABLE>
<S>        <C>                                                                              <C>
5.1.       Representations and Warranties of the Company..................................       A-12
5.2.       Representations and Warranties of Parent and Merger Sub........................       A-23
</TABLE>

                                  ARTICLE VI.
                                   COVENANTS

<TABLE>
<S>        <C>                                                                              <C>
6.1.       Interim Operations.............................................................       A-26
6.2.       Acquisition Proposals..........................................................       A-28
6.3.       Information Supplied...........................................................       A-29
6.4.       Stockholders Meeting...........................................................       A-30
6.5.       Filings; Other Actions; Notification...........................................       A-30
6.6.       Access; Consultation...........................................................       A-32
6.7.       Affiliates.....................................................................       A-32
6.8.       Stock Exchange Listing.........................................................       A-33
6.9.       Publicity......................................................................       A-33
</TABLE>

                                      A-2
<PAGE>
<TABLE>
<S>        <C>                                                                              <C>
6.10.      Employee Benefits..............................................................       A-33
6.11.      Expenses.......................................................................       A-35
6.12.      Indemnification; Directors' and Officers' Insurance............................       A-35
6.13.      Takeover Statutes..............................................................       A-36
6.14.      Confidentiality................................................................       A-37
6.15.      Tax-Free Reorganization........................................................       A-37
</TABLE>

                                  ARTICLE VII.
                                   CONDITIONS

<TABLE>
<S>        <C>                                                                              <C>
7.1.       Conditions to Each Party's Obligation to Effect the Merger.....................       A-37
7.2.       Conditions to Obligations of Parent and Merger Sub.............................       A-38
7.3.       Conditions to Obligation of the Company........................................       A-38
</TABLE>

                                 ARTICLE VIII.
                                  TERMINATION

<TABLE>
<S>        <C>                                                                              <C>
8.1.       Termination by Mutual Consent..................................................       A-39
8.2.       Termination by Either Parent or the Company....................................       A-39
8.3.       Termination by the Company.....................................................       A-40
8.4.       Termination by Parent..........................................................       A-40
8.5.       Effect of Termination and Abandonment..........................................       A-41
</TABLE>

                                  ARTICLE IX.
                           MISCELLANEOUS AND GENERAL

<TABLE>
<S>        <C>                                                                              <C>
9.1.       Certain Definitions............................................................       A-42
9.2.       Survival.......................................................................       A-43
9.3.       Modification or Amendment......................................................       A-44
9.4.       Waiver of Conditions...........................................................       A-44
9.5.       Counterparts...................................................................       A-44
9.6.       GOVERNING LAW AND VENUE; WAIVER OF JURY TRIAL..................................       A-44
9.7.       Notices........................................................................       A-45
9.8.       Entire Agreement...............................................................       A-46
9.9.       No Third Party Beneficiaries...................................................       A-46
9.10.      Obligations of Parent and of the Company.......................................       A-46
9.11.      Severability...................................................................       A-46
9.12.      Interpretation.................................................................       A-47
9.13.      Assignment.....................................................................       A-47
</TABLE>

                                    EXHIBITS

<TABLE>
<S>                                                                                    <C>
Exhibit 6.7(A)--Stockholder Agreement................................................       A-48
Exhibit 6.7(B)--Stockholder Agreement................................................       A-52
</TABLE>

                                      A-3
<PAGE>
                             INDEX OF DEFINED TERMS

<TABLE>
<CAPTION>
TERM                                                                                                  SECTION
- -----------------------------------------------------------------------------------------------  -----------------
<S>                                                                                              <C>
5% Debenture Indenture.........................................................................             4.5(a)
5% Debenture Trustee...........................................................................             4.5(a)
5% Debentures..................................................................................             5.1(b)
5- 1/4% Debenture Indenture....................................................................             4.5(b)
5- 1/4% Debenture Trustee......................................................................             4.5(b)
5- 1/4% Debentures.............................................................................             5.1(b)
Acquisition Proposal...........................................................................             6.2(a)
Activities to Date.............................................................................    5.1(p)(1)(A)(i)
Affiliates.....................................................................................                9.1
Agreement......................................................................................           preamble
Audit Date.....................................................................................             5.1(f)
Bankruptcy and Equity Exception................................................................             5.1(c)
Bylaws.........................................................................................                2.2
Certificate....................................................................................             4.1(a)
Certificate of Merger..........................................................................                1.3
Charter........................................................................................                2.1
Charter and Bylaw Provisions...................................................................             5.1(j)
Chase..........................................................................................             5.1(c)
Closing........................................................................................                1.2
Closing Date...................................................................................                1.2
Code...........................................................................................                9.1
Company........................................................................................           preamble
Company Affiliate's Letter.....................................................................             6.7(a)
Company Disclosure Letter......................................................................                5.1
Company IP Rights..............................................................................          5.1(r)(1)
Company Option.................................................................................         6.10(b)(i)
Company Preferred Shares.......................................................................             5.1(b)
Company Representatives........................................................................             6.2(a)
Company Required Consents......................................................................          5.1(d)(1)
Company Share..................................................................................             4.1(a)
Company Shares.................................................................................             4.1(a)
Company Stock Plans............................................................................             5.1(b)
Company's Executive Officers...................................................................                9.1
Company's Reports..............................................................................             5.1(e)
Compensation and Benefit Plans.................................................................          5.1(h)(i)
Competition Laws...............................................................................                9.1
Computer Systems...............................................................................             5.1(s)
Confidentiality Agreement......................................................................               6.14
Contracts......................................................................................          5.1(d)(2)
Convertible Debentures.........................................................................             5.1(b)
Crescendo......................................................................................                9.1
Crescendo Certificate of Incorporation.........................................................          5.1(t)(2)
Crescendo Payments.............................................................................          5.1(t)(2)
Crescendo Products.............................................................................          5.1(t)(2)
DGCL...........................................................................................                9.1
Delaware Courts................................................................................             9.6(a)
Effective Time.................................................................................                1.3
Environmental Law..............................................................................                9.1
</TABLE>

                                      A-4
<PAGE>
<TABLE>
<CAPTION>
TERM                                                                                                  SECTION
- -----------------------------------------------------------------------------------------------  -----------------
<S>                                                                                              <C>
ERISA..........................................................................................                9.1
ERISA Affiliate................................................................................                9.1
Exchange Act...................................................................................                9.1
Exchange Agent.................................................................................             4.2(a)
Exchange Ratio.................................................................................             4.1(a)
Excluded Company Shares........................................................................             4.1(a)
FDCA...........................................................................................                9.1
GAAP...........................................................................................                9.1
Governmental Entity............................................................................          5.1(d)(1)
Hazardous Substance............................................................................                9.1
HSR Act........................................................................................                9.1
Indemnified Parties............................................................................            6.12(a)
IRS............................................................................................                9.1
Laws...........................................................................................                9.1
Licenses.......................................................................................    5.1(p)(1)(A)(i)
Material Adverse Effect........................................................................                9.1
Merger.........................................................................................           recitals
Merger Consideration...........................................................................             4.1(a)
Merger Sub.....................................................................................           preamble
Merrill Lynch..................................................................................             5.1(c)
Modified Recommendation Stockholder Rejection Termination......................................             8.5(b)
NYSE...........................................................................................                9.1
Order..........................................................................................             7.1(c)
Parent.........................................................................................           preamble
Parent Affiliate's Letter......................................................................             6.7(a)
Parent Common Stock............................................................................             4.1(a)
Parent Disclosure Letter.......................................................................                5.2
Parent Preferred Shares........................................................................          5.2(b)(1)
Parent Required Consents.......................................................................          5.2(d)(1)
Parent Stock Plans.............................................................................          5.2(b)(1)
Parent's Reports...............................................................................             5.2(e)
PBGC...........................................................................................                9.1
Pension Plan...................................................................................         5.1(h)(ii)
Permits........................................................................................                9.1
Person.........................................................................................                9.1
Pooling Affiliates.............................................................................             6.7(a)
Pooling Requirements...........................................................................           recitals
Products.......................................................................................       5.1(p)(1)(A)
Prospectus/Proxy Statement.....................................................................                6.3
Purchase Plans.................................................................................         6.10(a)(i)
Restricted Share...............................................................................            6.10(b)
Requisite Vote.................................................................................             5.1(c)
Rule 145 Affiliates............................................................................             6.7(a)
S-4 Registration Statement.....................................................................                6.3
SEC............................................................................................                9.1
Securities Act.................................................................................                9.1
Significant Agreements.........................................................................             5.1(q)
Significant Investees..........................................................................                9.1
Significant Subsidiaries.......................................................................                9.1
Stockholders Meeting...........................................................................                6.4
</TABLE>

                                      A-5
<PAGE>
<TABLE>
<CAPTION>
TERM                                                                                                  SECTION
- -----------------------------------------------------------------------------------------------  -----------------
<S>                                                                                              <C>
Subsequent Transaction.........................................................................             6.5(e)
Subsidiary.....................................................................................                9.1
Substitute Option..............................................................................         6.10(b)(i)
Substitute Restricted Shares...................................................................            6.10(b)
Superior Proposal..............................................................................             6.2(a)
Surviving Corporation..........................................................................                1.1
Takeover Statute...............................................................................             5.1(j)
Tax............................................................................................                9.1
Tax Return.....................................................................................                9.1
Taxable........................................................................................                9.1
Taxes..........................................................................................                9.1
Termination Date...............................................................................                8.2
Termination Fee................................................................................             8.5(b)
Warrant Agreement..............................................................................             4.5(c)
Warrants.......................................................................................             5.1(b)
Year 2000 Compliance...........................................................................             5.1(s)
Waiting Period.................................................................................                8.2
</TABLE>

                                      A-6
<PAGE>
                          AGREEMENT AND PLAN OF MERGER

    This AGREEMENT AND PLAN OF MERGER (this "AGREEMENT"), dated as of June 21,
1999, is among ALZA CORPORATION, a Delaware corporation (the "COMPANY"), ABBOTT
LABORATORIES, an Illinois corporation ("PARENT"), and AC MERGER SUB INC., a
Delaware corporation that is a wholly owned subsidiary of Parent ("MERGER SUB").

                                    RECITALS

    WHEREAS, the respective Boards of Directors of each of Parent, Merger Sub
and the Company have approved and declared advisable this Agreement and the
merger of Merger Sub with and into the Company (the "MERGER") upon the terms and
subject to the conditions set forth in this Agreement;

    WHEREAS, the parties intend, by executing and delivering this Agreement, to
adopt a plan of reorganization within the meaning of Section 368(a) of the Code,
and to cause the Merger to qualify as a "reorganization" as therein defined;

    WHEREAS, for financial accounting purposes, it is intended that the Merger
shall be accounted for as a "pooling-of-interests" in accordance with the
requirements of Opinion No. 16 "Business Combinations" of the Accounting
Principles Board of the American Institute of Certified Public Accountants, as
amended and/or interpreted by the rules and regulations of the SEC and
applicable pronouncements by the Financial Accounting Standards Board, the
Emerging Issues Task Force and the American Institute of Certified Public
Accountants (collectively, with the rules and regulations of the SEC, the
"POOLING REQUIREMENTS");

    WHEREAS, the Company, Parent and Merger Sub desire to make certain
representations, warranties, covenants and agreements in connection with this
Agreement.

    NOW, THEREFORE, in consideration of the premises, and of the
representations, warranties, covenants and agreements contained in this
Agreement, the parties agree as follows:

                                   ARTICLE I.
                      THE MERGER; CLOSING; EFFECTIVE TIME

    1.1  THE MERGER.  Upon the terms and subject to the conditions set forth in
this Agreement, at the Effective Time, Merger Sub shall be merged with and into
the Company and the separate corporate existence of Merger Sub shall thereupon
cease. The Company shall be the surviving corporation in the Merger (sometimes
referred to as the "SURVIVING CORPORATION") and shall continue to be governed by
the laws of the State of Delaware, and the separate corporate existence of the
Company, with all its rights, privileges, immunities, powers and franchises,
shall continue unaffected by the Merger except as set forth in Article II and
Article III. The Merger shall have the effects specified in the DGCL.

    1.2  CLOSING.  The closing of the Merger (the "CLOSING") shall take place
(i) at the offices of Mayer, Brown & Platt, 190 South LaSalle Street, Chicago,
Illinois, at 9:00 A.M., local time, on the second business day after the date on
which the last to be fulfilled or waived of the conditions set forth in Article
VII (other than those conditions that by their nature are to be satisfied at the
Closing, but subject to the fulfillment or waiver of those conditions) shall be
satisfied or waived in accordance with this Agreement or (ii) at such other
place and time and/or on such other date as the Company and Parent may agree in
writing (the "CLOSING DATE").

    1.3  EFFECTIVE TIME.  As soon as practicable following the Closing, the
Company and Parent will cause a Certificate of Merger (the "CERTIFICATE OF
MERGER") to be executed, acknowledged and filed with the Secretary of State of
the State of Delaware as provided in Section 251 of the DGCL. The Merger shall
become effective at the time when the Certificate of Merger has been duly filed
with the

                                      A-7
<PAGE>
Secretary of State of the State of Delaware or such other time as shall be
agreed upon by the parties and set forth in the Certificate of Merger in
accordance with the DGCL (the "EFFECTIVE TIME").

                                  ARTICLE II.
      CERTIFICATE OF INCORPORATION AND BYLAWS OF THE SURVIVING CORPORATION

    2.1  THE CERTIFICATE OF INCORPORATION.  The certificate of incorporation of
Merger Sub as in effect immediately prior to the Effective Time shall be the
certificate of incorporation of the Surviving Corporation (the "CHARTER"), until
duly amended as provided therein or by applicable law.

    2.2  THE BYLAWS.  The bylaws of Merger Sub in effect at the Effective Time
shall be the bylaws of the Surviving Corporation (the "BYLAWS"), until
thereafter amended as provided therein or by applicable law.

                                  ARTICLE III.
                       OFFICERS, DIRECTORS AND MANAGEMENT

    3.1  DIRECTORS OF SURVIVING CORPORATION.  The directors of Merger Sub at the
Effective Time shall, from and after the Effective Time, be the directors of the
Surviving Corporation until their successors have been duly elected or appointed
and qualified or until their earlier death, resignation or removal in accordance
with the Charter and the Bylaws.

    3.2  OFFICERS OF SURVIVING CORPORATION.  The officers of the Company at the
Effective Time shall, from and after the Effective Time, be the officers of the
Surviving Corporation until their successors have been duly elected or appointed
and qualified or until their earlier death, resignation or removal in accordance
with the Charter and the Bylaws.

                                  ARTICLE IV.
        EFFECT OF THE MERGER ON CAPITAL STOCK; EXCHANGE OF CERTIFICATES

    4.1  EFFECT ON CAPITAL STOCK.  At the Effective Time, the Merger shall have
the following effects on the capital stock of the Company and Merger Sub,
without any action on the part of the holder of any capital stock of the Company
or Merger Sub:

    (a)  MERGER CONSIDERATION.  Each share of common stock, $0.01 par value per
    share, of the Company (each a "COMPANY SHARE" and, collectively, the
    "COMPANY SHARES") issued and outstanding immediately prior to the Effective
    Time (but not including Company Shares that are owned by Parent, Merger Sub
    or any other direct or indirect subsidiary of Parent or Company Shares that
    are owned by the Company or any direct or indirect Subsidiary of the
    Company, and in each case not held on behalf of third parties (collectively,
    "EXCLUDED COMPANY SHARES")), shall be converted into and become exchangeable
    for 1.20 shares (the "EXCHANGE RATIO") of Common Stock, no par value, of
    Parent ("PARENT COMMON STOCK"), subject to adjustment as provided in Section
    4.4 (the "MERGER CONSIDERATION"). At the Effective Time, all Company Shares
    shall no longer be outstanding, shall be canceled and retired and shall
    cease to exist, and each certificate (a "CERTIFICATE") formerly representing
    any of such Company Shares (other than Excluded Company Shares) shall
    thereafter represent only the right to the Merger Consideration and the
    right, if any, to receive pursuant to Section 4.2(e) cash in lieu of the
    fractional shares into which such Company Shares have been converted
    pursuant to this Section 4.1(a) and any distribution or dividend pursuant to
    Section 4.2(c), in each case without interest.

    (b)  CANCELLATION OF EXCLUDED COMPANY SHARES.  Each Excluded Company Share
    issued and outstanding immediately prior to the Effective Time shall, by
    virtue of the Merger and without any

                                      A-8
<PAGE>
    action on the part of the holder thereof, no longer be outstanding, shall be
    canceled and retired without payment of any consideration therefor and shall
    cease to exist.

    (c)  MERGER SUB.  At the Effective Time, each share of Common Stock, par
    value $0.01 per share, of Merger Sub issued and outstanding immediately
    prior to the Effective Time shall be converted into one share of common
    stock of the Surviving Corporation, and the Surviving Corporation shall
    thereby become a wholly owned subsidiary of Parent.

    4.2  EXCHANGE OF CERTIFICATES FOR SHARES.

    (a)  EXCHANGE FUND.  Prior to the Effective Time, Parent shall appoint a
    bank or trust company, or a subsidiary thereof, having net capital of not
    less than $100 million, with the Company's prior approval, which shall not
    be unreasonably withheld, to act as exchange agent for the purposes of
    exchanging Certificates for Merger Consideration (the "EXCHANGE AGENT"). At
    or prior to the Effective Time, Parent shall deposit with the Exchange
    Agent, in trust for the benefit of holders of Company Shares, certificates
    representing shares of Parent Common Stock issuable pursuant to Section
    4.1(a). Parent agrees to make available to the Exchange Agent from time to
    time as needed, cash sufficient to pay cash in lieu of fractional shares in
    accordance with Section 4.2(e).

    (b)  EXCHANGE PROCEDURES.  Promptly after the Effective Time, the Surviving
    Corporation shall cause the Exchange Agent to mail to each holder of record
    as of the Effective Time of a Certificate in respect of Company Shares
    (other than holders of a Certificate in respect of Excluded Company Shares)
    (i) a letter of transmittal specifying that delivery of the Certificates
    shall be effected, and that risk of loss and title to the Certificates shall
    pass, only upon delivery of the Certificates (or affidavits of loss and a
    reasonable undertaking to indemnify the Company in lieu thereof) to the
    Exchange Agent, such letter of transmittal to be in such form and have such
    other provisions as Parent and the Company may reasonably agree, and (ii)
    instructions for exchanging the Certificates for (A) certificates
    representing shares of Parent Common Stock and (B) any cash in lieu of
    fractional shares determined in accordance with Section 4.2(e) plus any cash
    dividends and any other dividends or other distributions that such holder
    has the right to receive pursuant to the provisions of this Article IV.
    Subject to Section 4.2(h), upon surrender of a Certificate for cancellation
    to the Exchange Agent together with such letter of transmittal, duly
    executed, the holder of such Certificate shall be entitled to receive in
    exchange therefor (x) a certificate representing that number of whole shares
    of Parent Common Stock that such holder is entitled to receive pursuant to
    this Section 4.2, and (y) a check in the amount (after giving effect to any
    required tax withholdings) of (A) any cash in lieu of fractional shares
    determined in accordance with Section 4.2(e) plus (B) any cash dividends and
    any other dividends or other distributions that such holder has the right to
    receive pursuant to the provisions of this Section 4.2. The Certificate so
    surrendered shall forthwith be canceled. No interest will be paid or accrued
    on any amount payable upon due surrender of any Certificate. In the event of
    a transfer of ownership of Company Shares that occurred prior to the
    Effective Time, but is not registered in the transfer records of the
    Company, a certificate representing the proper number of shares of Parent
    Common Stock, together with a check for any cash in lieu of fractional
    shares to be paid upon due surrender of the Certificate and any other
    dividends or distributions in respect thereof, may be issued and/or paid to
    such a transferee if the Certificate formerly representing such Company
    Shares is presented to the Exchange Agent, accompanied by all documents
    required to evidence and effect such transfer and to evidence that any
    applicable stock transfer taxes have been paid. If any certificate for
    shares of Parent Common Stock is to be issued in a name other than that in
    which the Certificate surrendered in exchange therefor is registered, it
    shall be a condition of such exchange that the Person requesting such
    exchange shall pay any transfer or other taxes required by reason of the
    issuance of certificates for shares of Parent Common Stock in a name other
    than that of the registered holder of the Certificate surrendered, or shall
    establish to the satisfaction of Parent or the Exchange Agent that such tax
    has been paid or is not applicable.

                                      A-9
<PAGE>
    (c)  DISTRIBUTIONS WITH RESPECT TO UNEXCHANGED SHARES; VOTING.

       (i) Whenever a dividend or other distribution is declared by Parent in
       respect of Parent Common Stock, the record date for which is at or after
       the Effective Time, that declaration shall include dividends or other
       distributions in respect of all shares of Parent Common Stock issuable
       pursuant to this Agreement. No dividends or other distributions so
       declared in respect of such Parent Common Stock shall be paid to any
       holder of any unsurrendered Certificate until such Certificate is
       surrendered for exchange in accordance with this Section 4.2. Subject to
       the effect of applicable laws, following surrender of any such
       Certificate, there shall be issued or paid to the holder of the
       certificates representing whole shares of Parent Common Stock issued in
       exchange for such Certificate, without interest, (A) at the time of such
       surrender, the dividends or other distributions with a record date that
       is at or after the Effective Time and a payment date on or prior to the
       date of issuance of such whole shares of Parent Common Stock and not
       previously paid and (B) at the appropriate payment date, the dividends or
       other distributions payable with respect to such whole shares of Parent
       Common Stock with a record date after the Effective Time but with a
       payment date subsequent to surrender. For purposes of dividends or other
       distributions in respect of shares of Parent Common Stock, all shares of
       Parent Common Stock to be issued pursuant to the Merger shall be deemed
       issued and outstanding as of the Effective Time.

       (ii) Registered holders of unsurrendered Certificates shall be entitled
       to vote after the Effective Time at any meeting of Parent stockholders
       with a record date at or after the Effective Time the number of whole
       shares of Parent Common Stock represented by such Certificates,
       regardless of whether such holders have exchanged their Certificates.

    (d)  TRANSFERS.  After the Effective Time, there shall be no transfers on
    the stock transfer books of the Company of the Company Shares that were
    outstanding immediately prior to the Effective Time.

    (e)  FRACTIONAL SHARES.  Notwithstanding any other provision of this
    Agreement, no fractional shares of Parent Common Stock will be issued and
    any holder of Company Shares entitled to receive a fractional share of
    Parent Common Stock but for this Section 4.2(e) shall be entitled to receive
    in lieu thereof an amount in cash (without interest) determined by
    multiplying such fraction (rounded to the nearest one-hundredth of a share)
    by the average closing price of a share of Parent Common Stock, as reported
    in The Wall Street Journal, New York City edition, on the five (5) trading
    days immediately prior to the Effective Time.

    (f)  TERMINATION OF EXCHANGE PERIOD; UNCLAIMED STOCK.  Any shares of Parent
    Common Stock and any portion of the cash, dividends or other distributions
    with respect to the Parent Common Stock deposited by Parent with the
    Exchange Agent (including the proceeds of any investments thereof) that
    remain unclaimed by the stockholders of the Company 180 days after the
    Effective Time shall be paid to Parent. Any stockholders of the Company who
    have not theretofore complied with this Article IV shall thereafter be
    entitled to look only to Parent for payment of their shares of Parent Common
    Stock and any cash, dividends and other distributions in respect thereof
    issuable and/or payable pursuant to Section 4.1, Section 4.2(c) and Section
    4.2(e) upon due surrender of their Certificates (or affidavits of loss and a
    reasonable undertaking to indemnify the Company in lieu thereof), in each
    case, without any interest thereon. Notwithstanding the foregoing, none of
    Parent, the Surviving Corporation, the Exchange Agent or any other Person
    shall be liable to any former holder of Company Shares for any amount
    properly delivered to a public official pursuant to applicable abandoned
    property, escheat or similar laws.

    (g)  LOST, STOLEN OR DESTROYED CERTIFICATES.  In the event any Certificate
    shall have been lost, stolen or destroyed, upon the making of an affidavit
    of that fact by the Person claiming such Certificate to be lost, stolen or
    destroyed and the posting by such Person of a bond in the form customarily

                                      A-10
<PAGE>
    required by Parent as indemnity against any claim that may be made against
    it with respect to such Certificate, Parent will issue the shares of Parent
    Common Stock and the Exchange Agent will distribute such stock, any cash,
    dividends and other distributions in respect thereof issuable or payable in
    exchange for such lost, stolen or destroyed Certificate pursuant to Section
    4.1, Section 4.2(c) and Section 4.2(e), in each case, without interest.

    (h)  AFFILIATES.  Notwithstanding anything in this Agreement to the
    contrary, Certificates surrendered for exchange by any Pooling Affiliate or
    Rule 145 Affiliate (as determined pursuant to Section 6.7) of the Company
    shall not be exchanged until Parent has received a written agreement from
    such Person as provided in Section 6.7.

    4.3  DISSENTERS' RIGHTS.  In accordance with Section 262 of the DGCL, no
appraisal rights will be available to holders of Company Shares in connection
with the Merger.

    4.4  ADJUSTMENTS TO PREVENT DILUTION.  In the event that prior to the
Effective Time, solely as a result of reclassification, stock split (including a
reverse split), or stock dividend or stock distribution made on a pro rata basis
to all holders of stock of the entity making such a stock dividend or stock
distribution, there is a change in the number of Company Shares or shares of
Parent Common Stock outstanding or issuable upon the conversion, exchange or
exercise of securities or rights convertible or exchangeable into or exercisable
for Company Shares or shares of Parent Common Stock issued and outstanding, the
Exchange Ratio shall be equitably adjusted to eliminate the effects of such
event.

    4.5  CONVERTIBLE DEBENTURES; WARRANTS.

    (a)  5% DEBENTURES.  At the Effective Time, the Company and Parent shall
    execute a supplemental indenture satisfying the requirements of Sections
    10.1(a) and (c), 11.1, 11.2 and 14.6 of the 5% Debenture Indenture dated as
    of April 23, 1996 (the "5% DEBENTURE INDENTURE") between the Company and The
    Chase Manhattan Bank, N.A., as Trustee (the "5% DEBENTURE TRUSTEE"), and the
    Company shall use its reasonable best efforts to cause the 5% Debenture
    Trustee to execute such supplemental indenture. The Company shall give the
    notice required by Section 14.10(3) of the 5% Debenture Indenture at least
    15 days prior to the Effective Time. Within 20 days after the Effective
    Time, Parent shall cause the Surviving Corporation to give the notice
    required by Section 14.6 of the 5% Debenture Indenture. On or before the
    30th day after the Effective Time, Parent shall cause the Surviving
    Corporation to give the notice required by Section 15.2 of the 5% Debenture
    Indenture.

    (b)  5- 1/4% DEBENTURES.  At the Effective Time, the Company and Parent
    shall execute a supplemental indenture satisfying the requirements of
    Sections 9.1(2) and 11.14 of the Indenture dated as of July 1, 1994 (the
    "5- 1/4% DEBENTURE INDENTURE") between the Company and The Chase Manhattan
    Bank, N.A., as Trustee (the "5- 1/4% DEBENTURE TRUSTEE"), and the Company
    shall use its reasonable best efforts to cause the 5- 1/4% Debenture Trustee
    to execute such supplemental indenture. Within 15 days after the Effective
    Time, Parent shall cause the Surviving Corporation to give the notice
    required by Section 3.9(b) of the 5- 1/4% Debenture Indenture. The Company
    and Parent shall comply with the requirements of Article 5 of the 5- 1/4%
    Debenture Indenture.

    (c)  WARRANTS.  At least 20 days prior to the record date (or expected
    record date) for determining stockholders entitled to vote at the
    Stockholders Meeting, and at least 20 days prior to the Effective Time, the
    Company shall send written notice of the Merger and the other transactions
    contemplated by this Agreement to the Warrant Agent (as defined in the
    Warrant Agreement dated as of May 14, 1993 between the Company and The First
    National Bank of Boston (the "WARRANT AGREEMENT")) and each Holder (as
    defined in the Warrant Agreement) of Warrants in the manner specified in
    Section 6.2 of the Warrant Agreement. At the Effective Time, the Company and
    Parent shall execute a supplement to the Warrant Agreement satisfying the
    requirements of

                                      A-11
<PAGE>
    Sections 5.4 and 11 thereof, and the Company shall use its reasonable best
    efforts to cause the Warrant Agent to execute such supplement.

                                   ARTICLE V.
                         REPRESENTATIONS AND WARRANTIES

    5.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  Except as set forth in
the corresponding sections or subsections of the disclosure letter, dated the
date of this Agreement, delivered by the Company to Parent (the "COMPANY
DISCLOSURE LETTER") (it being understood that the omission of an item from a
section or subsection of the Company Disclosure Letter shall not cause a breach
of this Agreement if such item is disclosed in another section or subsection of
the Company Disclosure Letter in a manner which makes the item understandably
applicable to the section or subsection from which such item is omitted), the
Company represents and warrants to Parent and Merger Sub that:

    (a)  ORGANIZATION, GOOD STANDING AND QUALIFICATION.  Each of the Company and
    its Subsidiaries is a corporation duly organized, validly existing and in
    good standing under the laws of its respective jurisdiction of organization
    and has all requisite corporate or similar power and authority to own and
    operate its properties and assets and to carry on its business as presently
    conducted and is qualified to do business and is in good standing as a
    foreign corporation in each jurisdiction where the ownership or operation of
    its properties or conduct of its business requires such qualification,
    except where the failure to be so qualified or in good standing is not, when
    taken together with all other such failures, reasonably likely to have a
    Material Adverse Effect on it. The Company has made available to Parent a
    complete and correct copy of its certificate of incorporation and bylaws,
    each as amended to date. Such certificate of incorporation and bylaws are in
    full force and effect.

    (b)  CAPITAL STRUCTURE.  The authorized capital stock of the Company
    consists of 300,000,000 Company Shares, of which 101,143,167 Company Shares
    were issued and outstanding and none were held in treasury as of the close
    of business on June 17, 1999, and 100,000 shares of Preferred Stock, par
    value $0.01 per share (the "COMPANY PREFERRED SHARES"), none of which were
    outstanding as of the date hereof. All of the outstanding Company Shares
    have been duly authorized and are validly issued, fully paid and
    nonassessable. Other than Company Shares subject to issuance as set forth
    below or that are permitted to become subject to issuance pursuant to
    Section 6.1(a)(iv) or (vii) of this Agreement, the Company has no Company
    Shares, Company Preferred Shares or other shares of capital stock reserved
    for or otherwise subject to issuance. As of the date of this Agreement, the
    Company has outstanding $500,000,000 aggregate principal amount of 5%
    convertible subordinated debentures due 2006 (the "5% DEBENTURES") and
    $945,481,000 aggregate principal amount at maturity of 5- 1/4% zero coupon
    convertible subordinated debentures due 2014 (the "5- 1/4% DEBENTURES" and,
    together with the 5% Debentures, the "CONVERTIBLE DEBENTURES") which, in the
    aggregate, are convertible into 25,371,112 Company Shares. As of the date of
    this Agreement, the Company has outstanding warrants to purchase 966,798
    Company Shares at an exercise price of $65.00 per Company Share (the
    "WARRANTS"). As of June 17, 1999, there were 9,785,067 Company Shares that
    the Company was obligated to issue pursuant to the Company's stock plans,
    each of which are listed in Section 5.1(b) of the Company Disclosure Letter
    (collectively, the "COMPANY STOCK PLANS"). Each of the outstanding shares of
    capital stock or other securities of each of the Company's Significant
    Subsidiaries is duly authorized, validly issued, fully paid and
    nonassessable and owned by the Company or a direct or indirect wholly owned
    Subsidiary of the Company, free and clear of any lien, pledge, security
    interest, claim or other encumbrance. Except as set forth above, there are
    no preemptive or other outstanding rights, options, warrants, conversion
    rights, stock appreciation rights, redemption rights, repurchase rights,
    agreements, arrangements or commitments to issue or sell any shares of
    capital stock, other securities or assets of the Company or any of its
    Significant Subsidiaries or any securities or obligations convertible or
    exchangeable into or exercisable for, or giving any Person a right to
    subscribe for or acquire, any

                                      A-12
<PAGE>
    shares of capital stock, other securities or assets of the Company or any of
    its Significant Subsidiaries, and no securities or obligations evidencing
    such rights are authorized, issued or outstanding. The Company does not have
    outstanding any bonds, debentures, notes or other debt obligations the
    holders of which have the right to vote or, except for the Convertible
    Debentures, convertible into or exercisable for securities having the right
    to vote with the stockholders of the Company on any matter. No Company
    Shares are held by a Subsidiary of the Company.

    (c)  CORPORATE AUTHORITY; APPROVAL AND FAIRNESS.  The Company has all
    requisite corporate power and authority and has taken all corporate action
    necessary in order to execute, deliver and perform its obligations under
    this Agreement and, subject only to adoption of this Agreement by the
    holders of at least a majority of the outstanding Company Shares (the
    "REQUISITE VOTE") and the Company Required Consents, to consummate the
    Merger. This Agreement has been duly executed and delivered by the Company
    and is a valid and binding agreement of the Company enforceable against the
    Company in accordance with its terms, subject to bankruptcy, insolvency,
    fraudulent transfer, reorganization, moratorium and similar laws of general
    applicability relating to or affecting creditors' rights and to general
    equity principles (the "BANKRUPTCY AND EQUITY EXCEPTION"). The Board of
    Directors of the Company (A) has unanimously approved and declared advisable
    this Agreement and the Merger and the other transactions contemplated by
    this Agreement and (B) has received the opinions of its financial advisors,
    Chase Securities Inc. ("CHASE") and Merrill Lynch & Co. ("MERRILL LYNCH"),
    in a customary form and to the effect that the Exchange Ratio is fair to the
    holders of the Company Shares from a financial point of view.

    (d)  GOVERNMENTAL FILINGS; NO VIOLATIONS.

       (1) Other than the filings and/or notices (A) pursuant to Section 1.3,
       (B) under the HSR Act, the Securities Act and the Exchange Act, (C)
       pursuant to the European Community Merger Control Regulation, (D) to
       comply with state securities or "blue-sky" laws and (E) to comply with
       any other relevant Competition Laws (including such laws in Canada and,
       if necessary, Japan) (such filings and/or notices of the Company being
       the "COMPANY REQUIRED CONSENTS"), no notices, reports or other filings
       are required to be made by the Company with, nor are any consents,
       registrations, approvals, permits or authorizations required to be
       obtained by the Company from, any governmental or regulatory authority,
       court, agency, commission, body or other governmental entity
       ("GOVERNMENTAL ENTITY"), in connection with the execution and delivery of
       this Agreement by the Company and the consummation by the Company of the
       Merger and the other transactions contemplated by this Agreement, except
       those that the failure to make or obtain are not, individually or in the
       aggregate, reasonably likely to have a Material Adverse Effect on the
       Company and prevent, materially delay or materially impair the Company's
       ability to consummate the transactions contemplated by this Agreement.

       (2) The execution, delivery and performance of this Agreement by the
       Company do not, and the consummation by the Company of the Merger and the
       other transactions contemplated by this Agreement will not, constitute or
       result in (A) a breach or violation of, or a default under, the Company's
       certificate of incorporation or bylaws or the comparable governing
       instruments of any of the Company's Significant Investees or, (B) a
       breach or violation of, or a default under, the acceleration of any
       obligations or the creation of a lien, pledge, security interest or other
       encumbrance on its assets or the assets of any of the Company's
       Significant Investees (with or without notice, lapse of time or both)
       pursuant to, any agreement, lease, contract, note, mortgage, indenture,
       arrangement or other obligation (whether oral or written) ("CONTRACTS")
       binding upon the Company or any of its Significant Investees or any Law
       or governmental or non-governmental permit or license to which the
       Company or any of its Significant Investees is subject or (C) any change
       in the rights or obligations of any party under any Contracts to which
       the Company or its Significant Investees are a party, except, in the case
       of clauses (B) or (C) above, for any breach, violation, default,
       acceleration, creation

                                      A-13
<PAGE>
       or change that, individually or in the aggregate, is not reasonably
       likely to have a Material Adverse Effect on the Company and prevent,
       materially delay or materially impair the Company's ability to consummate
       the transactions contemplated by this Agreement. The Company Disclosure
       Letter sets forth a correct and complete list of Contracts of the Company
       and its Significant Investees pursuant to which consents or waivers are
       or may be required prior to consummation of the transactions contemplated
       by this Agreement other than those where the failure to obtain such
       consents or waivers is not, individually or in the aggregate, reasonably
       likely to have a Material Adverse Effect on the Company and is not,
       individually or in the aggregate, reasonably likely to prevent or
       materially impair the Company's ability to consummate the transactions
       contemplated by this Agreement.

    (e)  REPORTS; FINANCIAL STATEMENTS.  The Company has filed with the SEC all
    required forms, reports, registration statements and documents required to
    be filed by it with the SEC since December 31, 1996. The Company has made
    available to Parent each registration statement, report, proxy statement or
    information statement filed by the Company since December 31, 1996,
    including the Company's Annual Report on Form 10-K for the years ended
    December 31, 1996, December 31, 1997 and December 31, 1998 and the Company's
    Quarterly Report on Form 10-Q for the quarter ended March 31, 1999 in the
    form (including exhibits, annexes and any amendments thereto) filed with the
    SEC (collectively, including any such reports filed subsequent to the date
    of this Agreement, the "COMPANY'S REPORTS").

    As of their respective dates, the Company's Reports complied as to form with
    all applicable requirements under the Securities Act, the Exchange Act and
    the rules and regulations thereunder and did not contain any untrue
    statement of a material fact or omit to state a material fact required to be
    stated therein or necessary to make the statements made therein, in light of
    the circumstances in which they were made, not misleading. Each of the
    consolidated balance sheets included in or incorporated by reference into
    the Company's Reports (including the related notes and schedules) fairly
    presents the consolidated financial position of the Company and its
    Subsidiaries as of its date and each of the consolidated statements of
    income, stockholders' equity and of cash flows included in or incorporated
    by reference into the Company's Reports (including any related notes and
    schedules) fairly presents the consolidated results of operations, retained
    earnings and cash flows, as the case may be, of the Company and its
    Subsidiaries for the periods set forth therein (subject, in the case of
    unaudited statements, to the absence of notes (to the extent permitted by
    the rules applicable to Form 10-Q) and to normal year-end audit adjustments
    that will not be material in amount or effect), in each case in accordance
    with GAAP consistently applied during the periods involved, except as may be
    noted therein. To the Company's knowledge, as of the date of this Agreement,
    no Person or "group" "beneficially owns" 5% or more of the Company's
    outstanding voting securities, with the terms "beneficially owns" and
    "group" having the meanings ascribed to them under Rule 13d-3 and Rule 13d-5
    under the Exchange Act.

    (f)  ABSENCE OF CERTAIN CHANGES.  Except as disclosed in the Company's
    Reports filed prior to the date of this Agreement or as expressly
    contemplated by this Agreement, since December 31, 1998 (the "AUDIT DATE"),
    the Company and its Subsidiaries have conducted their respective businesses
    only in, and have not engaged in any material transaction other than in
    accordance with, the ordinary and usual course of such businesses and there
    has not been: (i) any change in the financial condition, liabilities and
    assets (taken together), business or results of operations of the Company
    and its Subsidiaries, except those changes that are not, individually or in
    the aggregate, reasonably likely to have a Material Adverse Effect on the
    Company; (ii) any damage, destruction or other casualty loss with respect to
    any asset or property owned, leased or otherwise used by the Company or any
    of its Subsidiaries, whether or not covered by insurance, which damage,
    destruction or loss is reasonably likely, individually or in the aggregate,
    to have a Material Adverse Effect on the Company; (iii) any declaration,
    setting aside or payment of any dividend or other

                                      A-14
<PAGE>
    distribution in respect of the Company's capital stock; or (iv) any change
    by the Company in accounting principles, practices or methods, except as
    required by GAAP. Since the Audit Date, except as provided for in this
    Agreement, in the Company Disclosure Letter or as disclosed in the Company's
    Reports filed prior to the date of this Agreement, there has not been any
    increase in the salary, wage, bonus, grants, awards, benefits or other
    compensation payable or that could become payable by the Company or any of
    its Subsidiaries to directors, officers or key employees or any amendment of
    any of the Company's Compensation and Benefit Plans other than increases or
    amendments in the normal and usual course of the Company's business (which
    may include normal periodic performance reviews and related compensation and
    benefit increases and the provision of new individual compensation and
    benefits for promoted or newly hired officers and employees on terms
    consistent with past practice).

    (g)  LITIGATION AND LIABILITIES.  Except as disclosed in the Company's
    Reports filed prior to the date of this Agreement, there are no (i) civil,
    criminal or administrative actions, suits, claims, hearings, investigations
    or proceedings pending or, to the actual knowledge of the Company's
    Executive Officers, threatened against the Company or any of its
    Subsidiaries or (ii) obligations or liabilities of the Company or any of its
    Subsidiaries, whether or not accrued, contingent or otherwise and whether or
    not required to be disclosed, including those relating to matters involving
    any Environmental Law, except in each case for those that are not,
    individually or in the aggregate, reasonably likely (x) to have a Material
    Adverse Effect on the Company and (y) to prevent, materially delay or
    materially impair the Company's ability to consummate the transactions
    contemplated by this Agreement. The litigation matters set forth in Section
    5.1(g) of the Company Disclosure Letter, taken as a whole, are not
    reasonably likely to have a Material Adverse Effect on the Company.

    (h)  EMPLOYEE BENEFITS.

       (i) Except as set forth in Section 5.1(h) of the Company Disclosure
       Letter, none of the Company or any ERISA Affiliate maintains, is a party
       to, participates in or has any liability or contingent liability with
       respect to any employee benefit plan (within the meaning of Section 3(3)
       of ERISA) or any bonus, deferred compensation, pension, retirement,
       profit-sharing, thrift, savings, employee stock ownership, stock bonus,
       stock purchase, restricted stock, stock option, employment, consulting,
       termination, severance, compensation, medical, health or fringe benefit
       plan, or other plan, program, agreement, policy or arrangement for any
       agents, consultants, employees, directors, former employees or former
       directors of the Company and or any ERISA Affiliate which does not
       constitute an employee benefit plan (which employee benefit plans and
       other plans, programs, agreements, policies and arrangements are
       collectively referred to as the "COMPENSATION AND BENEFIT PLANS"). A true
       and correct copy of each Compensation and Benefit Plan and, to the extent
       applicable, copies of the most recent annual report, actuarial report,
       accountant's opinion of the plan's financial statements, summary plan
       description and IRS determination letter with respect to any Compensation
       and Benefit Plans and any trust agreements or insurance contracts forming
       a part of such Compensation and Benefit Plans has been made available by
       the Company to Parent prior to the date of this Agreement. In the case of
       any Compensation and Benefit Plan which is not in written form, the
       Company has supplied to Parent an accurate description of such
       Compensation and Benefit Plan as in effect on the date of this Agreement.

                                      A-15
<PAGE>
       (ii) All Compensation and Benefit Plans have been administered in
       substantial compliance with all requirements of applicable law, including
       the Code and ERISA, and no event has occurred which will or could cause
       any such Compensation and Benefit Plan to fail to comply with such
       requirements and no notice has been issued by any governmental authority
       questioning or challenging such compliance. There have been no acts or
       omissions by the Company or any ERISA Affiliate which have given rise to
       or may give rise to fines, penalties, taxes or related charges under
       Section 502 of ERISA or Chapters 43, 47, 68 or 100 of the Code for which
       the Company or any ERISA Affiliate may be liable. Each of the
       Compensation and Benefit Plans that is an "employee pension benefit plan"
       within the meaning of Section 3(2) of ERISA, other than a multiemployer
       plan (as defined in Section 3(37) of ERISA), each a "PENSION PLAN," and
       that is intended to be qualified under Section 401(a) of the Code has
       received a favorable determination letter from the IRS which covers all
       changes in law for which the remedial amendment period (within the
       meaning of Section 401(b) of the Code and applicable regulations) has
       expired and none of the Company nor any of its ERISA Affiliates is aware
       of any circumstances likely to result in revocation of any such favorable
       determination letter. There is no pending or, to the knowledge of the
       Company's Executive Officers, threatened material litigation relating to
       its Compensation and Benefit Plans. Neither the Company nor any of the
       ERISA Affiliates has engaged in a transaction with respect to any of the
       Compensation and Benefit Plans that, assuming the taxable period of such
       transaction expired as of the date of this Agreement, would subject the
       Company or any of the ERISA Affiliates to a material tax or penalty
       imposed by either Section 4975 of the Code or Section 502 of ERISA.

       (iii) All contributions required to be made under the terms of any of the
       Compensation and Benefit Plans as of the date of this Agreement have been
       timely made or have been reflected on the most recent consolidated
       balance sheet filed or incorporated by reference in the Company's Reports
       filed prior to the date of this Agreement.

       (iv) None of the Company or any ERISA Affiliate have any obligations for
       post-employment health and life benefits under any of the Compensation
       and Benefit Plans, except as set forth in the Company's Reports filed
       prior to the date of this Agreement or as required by applicable law.

       (v) Except as set forth in Section 5.1(h)(v) of the Company Disclosure
       Letter, the consummation of the Merger (or the approval of the Merger by
       stockholders of the Company) and the other transactions contemplated by
       this Agreement will not (x) entitle any employees or directors of the
       Company or any employees of any of the Company's ERISA Affiliates to
       severance pay, directly or indirectly, upon termination of employment or
       otherwise, (y) accelerate the time of payment or vesting or trigger any
       payment of compensation or benefits under, increase the amount payable or
       trigger any other material obligation pursuant to, any of the
       Compensation and Benefit Plans or (z) result in any breach or violation
       of, or a default under, any of the Compensation and Benefit Plans.

       (vi) None of the Compensation and Benefit Plans is a multiemployer plan,
       none of the Compensation and Benefit Plans is otherwise subject to Title
       IV of ERISA and none of the Company or any of the ERISA Affiliates have
       contributed or been obligated to contribute to a multiemployer plan or
       any other plan which is subject to Title IV of ERISA.

       (vii) Prior to the date of this Agreement, the Company has made its 1999
       annual grant of stock based awards under its Compensation and Benefit
       Plans and does not intend to make any additional grants of stock based
       awards until its 2000 annual grant of stock based awards under its
       Compensation and Benefit Plans except as may be expressly permitted by
       Section 6.1(a)(iv).

                                      A-16
<PAGE>
       (viii) Except as set forth in Section 5.1(h)(viii) of the Company's
       Disclosure Letter, no person is eligible or may become eligible for
       benefits under the Company's Executive Severance Plan.

    (i)  COMPLIANCE WITH LAWS.  Except as set forth in the Company's Reports
    filed prior to the date of this Agreement, the businesses of each of the
    Company and its Subsidiaries have not been, and are not being, conducted in
    violation of any Laws except for violations or possible violations that are
    not, individually or in the aggregate, reasonably likely to have a Material
    Adverse Effect on the Company and are not, individually or in the aggregate,
    reasonably likely to prevent, materially delay or materially impair the
    Company's ability to consummate the transactions contemplated by this
    Agreement. Except as set forth in the Company's Reports filed prior to the
    date of this Agreement, no investigation or review by any Governmental
    Entity with respect to the Company or any of its Subsidiaries is pending or,
    to the actual knowledge of the Company's Executive Officers, threatened,
    nor, to the actual knowledge of the Company's Executive Officers, has any
    Governmental Entity indicated an intention to conduct the same, except for
    those the outcome of which are not, individually or in the aggregate,
    reasonably likely to have a Material Adverse Effect on the Company and are
    not, individually or in the aggregate, reasonably likely to prevent,
    materially delay or materially impair the Company's ability to consummate
    the transactions contemplated by this Agreement. To the actual knowledge of
    the Company's Executive Officers, no material change is required in the
    Company's or any of its Subsidiaries' processes, properties or procedures in
    order to comply with any such Laws, and the Company has not received any
    notice or communication of any material noncompliance with any such Laws
    that has not been cured as of the date of this Agreement, except for such
    changes and noncompliance that are not, individually or in the aggregate,
    reasonably likely to have a Material Adverse Effect on the Company or
    prevent, materially delay or materially impair the Company's ability to
    consummate the transactions contemplated by this Agreement. Each of the
    Company and its Subsidiaries has all Permits necessary to conduct its
    business as presently conducted, except for those the absence of which are
    not, individually or in the aggregate, reasonably likely to have a Material
    Adverse Effect on the Company or prevent, materially delay or materially
    impair the Company's ability to consummate the transactions contemplated by
    this Agreement.

    (j)  TAKEOVER STATUTES; CHARTER AND BYLAW PROVISIONS.  The Board of
    Directors of the Company has taken all appropriate and necessary actions
    such that either Parent or Merger Sub, as "interested stockholders", will be
    permitted at any time to enter into one or more "business combinations"
    (within the meaning of Section 203(c)(3) of the DGCL) with the Company,
    despite the execution and delivery of this Agreement, and despite the
    consummation of the transactions contemplated by this Agreement. No other
    "fair price," "moratorium," "control share acquisition" or other similar
    anti-takeover statute or regulation (each a "Takeover Statute") as in effect
    on the date of this Agreement is applicable to the Company, the Company
    Shares, the Merger or the other transactions contemplated by this Agreement.
    No anti-takeover provision contained in the Company's certificate of
    incorporation, including Article 10 thereof, or its bylaws (collectively,
    "Charter and Bylaw Provisions") is, or at the Effective Time will be,
    applicable to the Merger or the other transactions contemplated by this
    Agreement in any manner that would prevent or make materially burdensome to
    Parent the Merger or the other transactions contemplated by this Agreement.

    (k)  ENVIRONMENTAL MATTERS.  Except as disclosed in the Company's Reports
    filed prior to the date of this Agreement and except for such matters that,
    alone or in the aggregate, are not reasonably likely to have a Material
    Adverse Effect on the Company: (i) each of the Company and its Subsidiaries
    has complied with all applicable Environmental Laws; (ii) the properties
    currently owned or operated by the Company or any of its Subsidiaries
    (including soils, groundwater, surface water, buildings or other structures)
    are not contaminated with any Hazardous Substances; (iii) the properties
    formerly owned or operated by the Company or any of its Subsidiaries were
    not contaminated with Hazardous Substances during the period of ownership or
    operation by the

                                      A-17
<PAGE>
    Company or any of its Subsidiaries; (iv) neither the Company nor any of its
    Subsidiaries is subject to liability for any Hazardous Substance disposal or
    contamination on any third party property; (v) neither the Company nor any
    of its Subsidiaries has been associated with any release or threat of
    release of any Hazardous Substance; (vi) neither the Company nor any of its
    Subsidiaries has received any notice, demand, letter, claim or request for
    information alleging that the Company or any of its Subsidiaries may be in
    violation of or liable under any Environmental Law; (vii) neither the
    Company nor any of its Subsidiaries is subject to any orders, decrees,
    injunctions or other arrangements with any Governmental Entity or is subject
    to any indemnity or other agreement with any third party relating to
    liability under any Environmental Law or relating to Hazardous Substances;
    and (viii) there are no circumstances or conditions involving the Company or
    any of its Subsidiaries that could reasonably be expected to result in any
    claims, liability, investigations, costs or restrictions on the ownership,
    use, or transfer of any of the Company's properties pursuant to any
    Environmental Law.

    (l)  ACCOUNTING AND TAX MATTERS.  Neither the Company nor any of its
    Subsidiaries or Pooling Affiliates has taken or agreed to take any action,
    nor do the Company's Executive Officers have any actual knowledge of any
    fact or circumstance, that would prevent Parent from accounting for the
    business combination to be effected by the Merger as a
    "pooling-of-interests" in accordance with the Pooling Requirements or
    prevent the Merger and the other transactions contemplated by this Agreement
    from qualifying as a "reorganization" within the meaning of Section 368(a)
    of the Code. The Company and its Subsidiaries have provided to its
    independent auditors all information requested by such auditors to assess
    whether the Merger can be properly accounted for as a "pooling-of-interests"
    in accordance with the Pooling Requirements, and have fully cooperated with
    such auditors with respect to all reasonable requests made in connection
    with such assessment.

    (m)  TAXES.  The Company and each of its Subsidiaries have prepared in good
    faith and duly and timely filed (taking into account any extension of time
    within which to file) all material Tax Returns required to be filed by any
    of them at or before the Effective Time and all such filed Tax Returns are
    complete and accurate in all material respects. The Company and each of its
    Subsidiaries as of the Effective Time (x) will have paid or adequately
    provided for all Taxes that they are required to pay prior to the Effective
    Time, and (y) will have withheld all United States federal, state and local
    income taxes, FICA, FUTA and other Taxes, including, without limitation,
    similar foreign Taxes, required to be withheld from amounts owing to any
    employee, creditor or third party, except for such amounts that, alone or in
    the aggregate, are not reasonably likely to have a Material Adverse Effect
    on the Company. As of the date of this Agreement, there are not pending or
    threatened in writing, any audits, examinations, investigations or other
    proceedings in respect of Taxes or Tax matters. There are not, to the actual
    knowledge of the Company's Executive Officers, any unresolved questions,
    claims or outstanding proposed or assessed deficiencies concerning the
    Company or any of its Subsidiaries' Tax liability that are reasonably likely
    to have a Material Adverse Effect on the Company. Neither the Company nor
    any of its Subsidiaries has any liability with respect to income, franchise
    or similar Taxes in excess of the amounts accrued in respect of such Taxes
    that are reflected in the financial statements included in the Company's
    Reports, except such excess liabilities as are not, individually or in the
    aggregate, reasonably likely to have a Material Adverse Effect on the
    Company. Neither the Company nor any of its Subsidiaries has executed any
    waiver of any statute of limitations on, or extended the period for the
    assessment or collection of, any Tax. Except as previously disclosed to
    Parent, no payments to be made to any of the officers and employees of the
    Company or its Subsidiaries will, as a result of consummation of the Merger,
    be subject to the deduction limitations under Sections 280G or 162(m) of the
    Code.

    (n)  LABOR MATTERS.  Neither the Company nor any of its Subsidiaries is the
    subject of any material proceeding asserting that the Company or any of its
    Subsidiaries has committed an unfair

                                      A-18
<PAGE>
    labor practice or is seeking to compel the Company to bargain with any labor
    union or labor organization nor is there pending or, to the knowledge of the
    Company's Executive Officers, threatened, nor has there been for the past
    five years, any labor strike, dispute, walkout, work stoppage, slow-down or
    lockout involving the Company or any of its Subsidiaries, except in each
    case as is not, individually or in the aggregate, reasonably likely to have
    a Material Adverse Effect on the Company.

    (o)  BROKERS AND FINDERS.  Neither the Company nor any of its officers,
    directors or employees has employed any broker or finder or incurred any
    liability for any brokerage fees, commissions or finders' fees in connection
    with the Merger or the other transactions contemplated by this Agreement
    except that the Company has employed Chase and Merrill Lynch as the
    Company's financial advisors. True and complete copies of all engagement
    letters and other Contracts under which Chase or Merrill Lynch may be
    entitled to any fees, expense reimbursement, indemnification or other
    payment from the Company or any of its Subsidiaries have been furnished to
    Parent.

    (p)  REGULATORY COMPLIANCE.

       (1) (A)  With respect to each of the Company's and its Subsidiaries'
       products and, to the extent applicable, products under development and
       the products and, to the extent applicable, products under development
       that the Company is entitled to license from Crescendo (collectively,
       "PRODUCTS"), (i) the Company, its Subsidiaries and, to the knowledge of
       the Company's Executive Officers, Crescendo have obtained all applicable
       approvals, clearances, authorizations, licenses and registrations
       required by United States or foreign governments or government agencies,
       to permit any manufacturing, distribution, sales, marketing or human
       research activities of the Company, its Subsidiaries and, to the
       knowledge of the Company's Executive Officers, Crescendo to date (the
       "ACTIVITIES TO DATE") with respect to each Product (collectively,
       "LICENSES"); (ii) the Company, its Subsidiaries and, to the knowledge of
       the Company's Executive Officers, Crescendo are in compliance in all
       material respects with all terms and conditions of each License and with
       all requirements pertaining to the Activities to Date with respect to
       each Product which is not required to be the subject of a License; (iii)
       the Company, its Subsidiaries and, to the knowledge of the Company's
       Executive Officers, Crescendo are in compliance in all material respects
       with all applicable requirements (as set forth in relevant statutes and
       regulations) regarding registration, licensure or notification for each
       site (in any country) at which each Product is manufactured, processed,
       packed, held for distribution or from which and into which it is
       distributed; and (iv) to the extent any Product is intended for export
       from the United States, the Company, its Subsidiaries and, to the
       knowledge of the Company's Executive Officers, Crescendo are in
       compliance in all material respects with either all FDA requirements for
       marketing or 21 U.S.C. Section 381(e) or Section 382; (B) all
       manufacturing operations performed by or on behalf of the Company, its
       Subsidiaries and, to the knowledge of the Company's Executive Officers,
       Crescendo have been and are being conducted in full compliance with
       current good manufacturing practice, including, but not limited to, the
       good manufacturing practice regulations issued by the FDA and counterpart
       requirements in Canada, the European Union and other countries; (C) all
       nonclinical laboratory studies of Products under development, as
       described in 21 C.F.R. Section 58.3(d), sponsored by the Company, its
       Subsidiaries and, to the knowledge of the Company's Executive Officers,
       Crescendo have been and are being conducted in full compliance with the
       good laboratory practice regulations set forth in 21 C.F.R. Part 58 and
       counterpart requirements in the European Union and other countries; and
       (D) the Company, its Subsidiaries and, to the knowledge of the Company's
       Executive Officers, Crescendo are in full compliance with all reporting
       requirements for all Licenses or plant registrations described in clause
       (1)(A) above, including, but not limited to, the adverse event reporting
       requirements for drugs in 21 C.F.R. Parts 312 and 314; except, in the
       case of the preceding clauses (1)(A) through (1)(D), for any such
       failures to obtain or noncompliance which, individually or

                                      A-19
<PAGE>
       in the aggregate, would not have a Material Adverse Effect on the
       Company. Without limiting the generality of the foregoing definition of
       "Licenses," such definition shall specifically include, with respect to
       the United States, new drug applications, abbreviated new drug
       applications, product license applications, investigational new drug
       applications, premarket approval applications, premarket notifications
       under Section 510(k) of the FDCA, and investigational device exemptions,
       and product export applications issued by the FDA.

       (2)  To the knowledge of the Company, neither the Company, Crescendo,
       their respective Subsidiaries nor any of their officers, employees or
       agents has made any untrue statement of a material fact or fraudulent
       statement to the FDA or any foreign equivalent, failed to disclose a fact
       required to be disclosed to the FDA or any foreign equivalent, or
       committed any act, made any statement, or failed to make any statement,
       that would reasonably be expected to provide a basis for the FDA to
       invoke its policy respecting, "Fraud, Untrue Statements of Material
       Facts, Bribery, and Illegal Gratuities," set forth in 56 Fed. Reg. 46191
       (September 10, 1991) or any foreign equivalent to invoke its equivalent
       policy.

       (3)  The Company has, prior to execution of this Agreement, made
       available to Parent copies of or made available for Parent's review any
       and all documents in its or any of its Subsidiaries' possession that the
       Company believes are material to assessing the Company's or any of its
       Subsidiaries' compliance with the FDCA and the Comprehensive Drug Abuse
       Prevention and Control Act of 1970 and implementing regulations,
       including, without limitation, copies in its possession of (i) all 483s
       issued during the last three years, (ii) any administrative or judicial
       order, ruling or agreement issued or entered into during the last three
       years in which the Company, any of its Subsidiaries, or any of their
       respective predecessor companies were a named party or were identified as
       an interested person, or (iii) any recall notice or order relating to any
       Product during the last two years.

    (q)  SIGNIFICANT AGREEMENTS.  Section 5.1(q) of the Company Disclosure
    Letter sets forth a complete and correct list of: (i) all Contracts required
    to be filed as an exhibit to the Company's Reports filed prior to the date
    hereof; (ii) all Contracts in effect as of the date of this Agreement that
    are reasonably expected to require the payment (whether by or to the Company
    or any of its Subsidiaries) of $15,000,000 or more in the aggregate or
    payments in any twelve-month period aggregating $4,000,000 or more; (iii)
    all Contracts between the Company and any of its Subsidiaries, on the one
    hand, and Crescendo and any of its Subsidiaries, on the other hand; (iv) all
    in-licenses or Contracts calling for the purchase or other acquisition by
    the Company or any of its Subsidiaries of rights to Products that generate
    or are reasonably expected to generate $10,000,000 or more of annualized
    revenues; and (v) all Contracts between the Company and any of its
    Subsidiaries, on the one hand, and any Affiliate of the Company, on the
    other hand (the Contracts described in (i) through (v), the "SIGNIFICANT
    AGREEMENTS"). The Company has heretofore made available to Parent complete
    and correct copies of each of the Significant Agreements, each as amended or
    modified to the date hereof (including any waivers with respect thereto).
    Each of the Significant Agreements is in full force and effect and
    enforceable in accordance with its terms, subject to the Bankruptcy and
    Equity Exception, except in each case where the failure to be in full force
    and effect and enforceable would not, individually or in the aggregate, be
    reasonably likely to have a Material Adverse Effect on the Company. None of
    the Company, any of its Subsidiaries or, to the knowledge of the Company's
    Executive Officers, Crescendo has received any notice (written or oral) of
    cancellation or termination of, or any expression or indication of an
    intention or desire to cancel or terminate, any of the Significant
    Agreements except in each case for those that are not, individually or in
    the aggregate, reasonably likely to have a Material Adverse Effect on the
    Company. No Significant Agreement is the subject of, or, to the knowledge of
    the Company's Executive Officers, has been threatened to be made the subject
    of, any arbitration, suit or other legal proceeding except in each case for
    those that are not, individually or in the aggregate, reasonably likely to
    have a Material Adverse Effect on the Company. With respect to any

                                      A-20
<PAGE>
    Significant Agreement which by its terms will terminate as of a certain date
    unless renewed or unless an option to extend such Significant Agreement is
    exercised, neither the Company, any of its Subsidiaries nor, to the
    knowledge of the Company's Executive Officers, Crescendo has received any
    notice (written or oral), or otherwise has any knowledge, that any such
    Significant Agreement will not be, or is not likely to be, so renewed or
    that any such extension option will not be exercised except in each case for
    those that are not, individually or in the aggregate, reasonably likely to
    have a Material Adverse Effect on the Company. There exists no event of
    default or occurrence, condition or act on the part of the Company or any of
    its Subsidiaries or, to the knowledge of the Company's Executive Officers,
    on the part of the other parties to the Significant Agreements which
    constitutes or would constitute (with notice or lapse of time or both) a
    breach of or default under any of the Significant Agreements except in each
    case for those that are not, individually or in the aggregate, reasonably
    likely to have a Material Adverse Effect on the Company.

    (r)  INTELLECTUAL PROPERTY RIGHTS.

       (1)  The Company, its Subsidiaries and, to the knowledge of the Company's
       Executive Officers, Crescendo own or have the right to use all
       intellectual property material to the conduct of their respective
       businesses (such intellectual property and such rights are collectively
       referred to herein as the "COMPANY IP RIGHTS"). Except under the
       Agreements disclosed in Section 5.1(q) of the Company Disclosure Letter,
       no royalties or other payments relating to the use of intellectual
       property rights are payable by the Company, its Subsidiaries, or, to the
       knowledge of the Company's Executive Officers, Crescendo to any Person
       with respect to commercialization of any products presently sold,
       manufactured by or for or under development by the Company, Crescendo and
       their respective Subsidiaries that are in excess of $2,000,000 per year
       for any single product.

       (2)  The execution, delivery and performance of this Agreement by the
       Company and the consummation by the Company of the transactions
       contemplated hereby will not (A) constitute a material breach by the
       Company, its Subsidiaries or, to the knowledge of the Company's Executive
       Officers, Crescendo of any material instrument or agreement governing any
       Company IP Rights, (B) cause the modification of any terms of any
       material licenses or agreements relating to any Company IP Rights
       including but not limited to the modification of the effective rate of
       any royalties or other payments provided for in any such license or
       agreement, (C) cause the forfeiture or termination of any material
       Company IP Rights, (D) give rise to a right of forfeiture or termination
       of any material Company IP Rights or (E) materially impair the right of
       the Company, its Subsidiaries, the Surviving Corporation, Parent or, to
       the knowledge of the Company's Executive Officers, Crescendo to make,
       have made, offer for sale, use, sell, export or license any material
       Company IP Rights or portion thereof.

       (3)  Except in each case as is not, individually or in the aggregate,
       reasonably likely to have a Material Adverse Effect on the Company,
       neither the manufacture, marketing, license, export, sale or intended use
       of any Product by the Company, its Subsidiaries or, to the knowledge of
       the Company's Executive Officers, Crescendo nor the current use by the
       Company, its Subsidiaries or, to the knowledge of the Company's Executive
       Officers, Crescendo, of any Company IP Rights (A) violates any license or
       agreement between the Company, Crescendo or any of their respective
       Subsidiaries and any third party or (B) infringes any patents or other
       intellectual property rights of any other party; and there is no pending
       or, to the knowledge of the Company's Executive Officers, threatened
       claim or litigation contesting the validity, ownership or right to use,
       sell, license or dispose of any Company IP Rights, or asserting that any
       Company IP Rights or the proposed use, sale, export, license or
       disposition thereof, or the manufacture, use or sale of any Products,
       conflicts or will conflict with the rights of any other party.

                                      A-21
<PAGE>
       (4)  The Company has heretofore made available to Parent a worldwide list
       of all patents, trade names, registered trademarks and registered service
       marks, and applications for any of the foregoing, owned or possessed by
       the Company, its Subsidiaries or, to the knowledge of the Company's
       Executive Officers, Crescendo and true and complete copies of such
       materials have been made available to Parent.

       (5)  The Company has provided to Parent a true and complete copy of the
       Company's, its Subsidiaries' and, to the knowledge of the Company's
       Executive Officers, Crescendo's standard form or forms of employee
       confidentiality agreements and other standard agreements relating to
       rights to inventions or other intellectual property and the Company, its
       Subsidiaries and, to the knowledge of the Company's Executive Officers,
       Crescendo have taken all commercially reasonably steps to ensure that all
       employees have executed such an agreement. All consultants or third
       parties with access to proprietary information of the Company, its
       Subsidiaries and, to the knowledge of the Company's Executive Officers,
       Crescendo have executed appropriate non-disclosure agreements.

    (s)  YEAR 2000 COMPLIANCE.  The Company has instituted processes and
    controls to attain Year 2000 Compliance, as that term is defined below, and
    the foreseeable expenses or other liabilities associated with the process of
    securing full Year 2000 Compliance would not be reasonably expected to have
    a Material Adverse Effect on the Company. "YEAR 2000 COMPLIANCE" means,
    except for any noncompliance that would not be reasonably expected to cause
    a Material Adverse Effect on the Company, that such hardware or software
    used by the Company or any of its Subsidiaries including, but not limited
    to, microcode, firmware, system and application programs, files, databases,
    computer services, and microcontrollers, including those embedded in
    computer and non-computer equipment (the "COMPUTER SYSTEMS") will:

       (1)  process date data from at least the years 1900 through 2101 without
       error or interruption;

       (2)  maintain functionality with respect to the introduction processing,
       or output of records containing dates falling on or after January 1,
       2000; and

       (3)  be interoperable with other software or hardware which may deliver
       records to, receive records from, or interact with such Computer Systems
       in the course of conducting the business of the Company, including
       processing data and manufacturing the products of the Company.

    (t)  CRESCENDO PHARMACEUTICALS CORPORATION.

       (1)  The Company owns 1,000 shares of Class B Common Stock of Crescendo
       free and clear of any lien, pledge, security interest, claim or other
       encumbrance. Such 1,000 shares constitute all of the issued and
       outstanding shares of Class B Common Stock of Crescendo.

       (2)  The Company's option to purchase all of the outstanding shares of
       Class A Common Stock of Crescendo is in full force and effect as of the
       date hereof and is enforceable in accordance with its terms as set forth
       in ARTICLE FIFTH of the Restated Certificate of Incorporation of
       Crescendo, a true and correct copy of which is attached as Section
       5.1(t)(2) of the Company Disclosure Letter (the "CRESCENDO CERTIFICATE OF
       INCORPORATION"). As of the date hereof, (i) the aggregate of the
       worldwide Product Payments, Developed Technology Royalties and Technical
       Evaluation Product Payments (as such terms are defined in the Crescendo
       Certificate of Incorporation) (the "CRESCENDO PAYMENTS") made by or due
       from the Company to Crescendo with respect to all Licensed Products,
       Developed Technology Products and Technical Evaluation Products (as such
       terms are defined in the Crescendo Certificate of Incorporation) (the
       "CRESCENDO PRODUCTS") for the four calender quarters immediately
       preceding the date hereof is approximately $500,000, (ii) the aggregate
       of the average quarterly Crescendo Payments made by or due from the
       Company to

                                      A-22
<PAGE>
       Crescendo with respect to all Crescendo Products which have not been
       commercially sold during each of the four calender quarters immediately
       preceding the date hereof is approximately $500,000, and (iii) the
       aggregate of all amounts paid by or due from Crescendo under the
       Development Agreement (as defined in the Crescendo Certificate of
       Incorporation) is approximately $163,000,000. The Company hereby
       represents and warrants that it has not exercised its payment buy-out
       option with respect to any of the Crescendo Products.

       (3)  As of the date hereof, the License Agreement dated December 16, 1998
       by and between the Company and Crescendo, a true and correct copy of
       which is attached as Section 5.1(t)(3) of the Company Disclosure Letter,
       is the only license agreement that has been executed by the Company and
       Crescendo pursuant to the License Option Agreement dated September 5,
       1997 by and between the Company and Crescendo.

    5.2  REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB. Except as set
forth in the corresponding sections or subsections of the disclosure letter,
dated the date of this Agreement, delivered by Parent to the Company (the
"PARENT DISCLOSURE LETTER"), Parent, on behalf of itself and Merger Sub,
represents and warrants to the Company that:

    (a)  ORGANIZATION, GOOD STANDING AND QUALIFICATION.  Each of Parent and its
    Subsidiaries is a corporation duly organized, validly existing and in good
    standing under the laws of its respective jurisdiction of organization and
    has all requisite corporate or similar power and authority to own and
    operate its properties and assets and to carry on its business as presently
    conducted and is qualified to do business and is in good standing as a
    foreign corporation in each jurisdiction where the ownership or operation of
    its properties or conduct of its business requires such qualification,
    except where the failure to be so qualified or in good standing is not, when
    taken together with all other such failures, reasonably likely to have a
    Material Adverse Effect on it. Parent has made available to Company a
    complete and correct copy of its articles of incorporation and bylaws, each
    as amended to date. Such articles of incorporation and bylaws are in full
    force and effect.

    (b)  CAPITAL STRUCTURE.

       (1)  The authorized capital stock of Parent consists of 2,400,000,000
       shares of Parent Common Stock, of which 1,520,806,248 were issued and
       outstanding and 17,591,970 shares were held in treasury as of the close
       of business on June 18, 1999, and 1,000,000 shares of Preferred Stock,
       par value $1.00 per share (the "PARENT PREFERRED SHARES"), of which no
       shares were outstanding as of the date hereof. All of the outstanding
       shares of Parent Common Stock have been duly authorized and are validly
       issued, fully paid and nonassessable. As of the date of this Agreement,
       other than Parent Common Stock subject to issuance as set forth below,
       Parent has no shares of Parent Common Stock or Parent Preferred Shares
       reserved for or subject to issuance. As of June 18, 1999, there were not
       more than 70,405,072 shares of Parent Common Stock that Parent was
       obligated to issue pursuant to Parent's stock plans, each of which are
       listed in Section 5.2(b) of the Parent Disclosure Letter (collectively,
       the "PARENT STOCK PLANS"). Except as set forth above, as of the date of
       this Agreement, there are no preemptive or other outstanding rights,
       options, warrants, conversion rights, stock appreciation rights,
       redemption rights, repurchase rights, agreements, arrangements or
       commitments to issue or to sell any shares of capital stock or other
       securities of Parent or any securities or obligations convertible or
       exchangeable into or exercisable for, or giving any Person a right to
       subscribe for or acquire, any securities of Parent, and no securities or
       obligations evidencing such rights are authorized, issued or outstanding.
       As of the date of this Agreement, Parent does not have outstanding any
       bonds, debentures, notes or other debt obligations the holders of which
       have the right to vote (or convertible into or exercisable for securities
       having the right to vote) with the stockholders of Parent on any matter.

                                      A-23
<PAGE>
       (2)  The authorized capital stock of Merger Sub consists of 1,000 shares
       of Common Stock, par value $0.01 per share, all of which are validly
       issued and outstanding. All of the issued and outstanding capital stock
       of Merger Sub is, and at the Effective Time will be, owned by Parent, and
       there are (i) no other shares of capital stock or other voting securities
       of Merger Sub, (ii) no securities of Merger Sub convertible into or
       exchangeable for shares of capital stock or other voting securities of
       Merger Sub and (iii) no options or other rights to acquire from Merger
       Sub, and no obligations of Merger Sub to issue, any capital stock, other
       voting securities or securities convertible into or exchangeable for
       capital stock or other voting securities of Merger Sub. Merger Sub has
       not conducted any business prior to the date of this Agreement and has
       no, and prior to the Effective Time will have no, assets, liabilities or
       obligations of any nature other than those incident to its formation and
       pursuant to this Agreement and the Merger and the other transactions
       contemplated by this Agreement.

    (c)  CORPORATE AUTHORITY AND APPROVAL.  Parent and Merger Sub each has all
    requisite corporate power and authority and each has taken all corporate
    action necessary in order to execute, deliver and perform its obligations
    under this Agreement, subject only to the Parent Required Consents, to
    consummate the Merger. This Agreement has been duly executed and delivered
    by Parent and Merger Sub and is a valid and binding agreement of Parent and
    Merger Sub, enforceable against each of Parent and Merger Sub in accordance
    with its terms, subject to the Bankruptcy and Equity Exception. The shares
    of Parent Common Stock, when issued pursuant to this Agreement, will be
    validly issued, fully paid and nonassessable, and no stockholder of Parent
    will have any preemptive right of subscription or purchase in respect
    thereof.

    (d)  GOVERNMENTAL FILINGS; NO VIOLATIONS.

       (1)  Other than the filings and/or notices (A) pursuant to Section 1.3,
       (B) under the HSR Act, the Securities Act and the Exchange Act, (C)
       pursuant to the European Community Merger Control Regulation, (D) to
       comply with state securities or "blue-sky" laws and (E) to comply with
       any other relevant Competition Laws (including such laws in Canada and,
       if necessary, Japan) (such filings and/or notices of Parent being the
       "PARENT REQUIRED CONSENTS"), no notices, reports or other filings are
       required to be made by Parent with, nor are any consents, registrations,
       approvals, permits or authorizations required to be obtained by Parent
       from, any Governmental Entity, in connection with the execution and
       delivery of this Agreement by Parent and the consummation by Parent of
       the Merger and the other transactions contemplated by this Agreement,
       except those that the failure to make or obtain are not, individually or
       in the aggregate, reasonably likely to have a Material Adverse Effect on
       Parent and are not, individually or in the aggregate, reasonably likely
       to prevent, materially delay or materially impair Parent's ability to
       consummate the transactions contemplated by this Agreement.

       (2)  The execution, delivery and performance of this Agreement by Parent
       do not, and the consummation by Parent of the Merger and the other
       transactions contemplated by this Agreement will not, constitute or
       result in (A) a breach or violation of, or a default under, Parent's
       articles of incorporation or bylaws or the comparable governing
       instruments of any of its Significant Subsidiaries or any Significant
       Investees, (B) a breach or violation of, or a default under, the
       acceleration of any obligations or the creation of a lien, pledge,
       security interest or other encumbrance on its assets or the assets of any
       of Parent's Significant Investees (with or without notice, lapse of time
       or both) pursuant to, any Contracts binding upon Parent or any of its
       Significant Investees or any Law or governmental or non-governmental
       permit or license to which Parent or any of its Significant Investees is
       subject or (C) any change in the rights or obligations of any party under
       any Contracts to which Parent or its Significant Investees are a party,
       except, in the case of clauses (B) or (C) above, for any breach,
       violation, default, acceleration, creation or change that, individually
       or in the

                                      A-24
<PAGE>
       aggregate, is not reasonably likely to have a Material Adverse Effect on
       Parent and is not, individually or in the aggregate, reasonably likely to
       prevent, materially delay or materially impair Parent's ability to
       consummate the transactions contemplated by this Agreement. The Parent
       Disclosure Letter sets forth a correct and complete list of Contracts of
       Parent and its Significant Investees pursuant to which consents or
       waivers are or may be required prior to consummation of the transactions
       contemplated by this Agreement other than those where the failure to
       obtain such consents or waivers is not, individually or in the aggregate,
       reasonably likely to have a Material Adverse Effect on Parent and is not,
       individually or in the aggregate, reasonably likely to prevent or
       materially impair Parent's ability to consummate the transactions
       contemplated by this Agreement.

    (e)  REPORTS; FINANCIAL STATEMENTS.  Parent has made available to the
    Company each registration statement, report, proxy statement or information
    statement prepared by Parent since December 31, 1996, including Parent's
    Annual Report on Form 10-K for the years ended December 31, 1996, December
    31, 1997 and December 31, 1998 and Parent's Quarterly Report on Form 10-Q
    for the quarter ended March 31, 1999 in the form (including exhibits,
    annexes and any amendments thereto) filed with the SEC (collectively,
    including any such reports filed subsequent to the date of this Agreement,
    "PARENT'S REPORTS"). As of their respective dates, Parent's Reports complied
    as to form with all applicable requirements under the Securities Act, the
    Exchange Act and the rules and regulations thereunder and did not contain
    any untrue statement of a material fact or omit to state a material fact
    required to be stated therein or necessary to make the statements made
    therein, in light of the circumstances in which they were made, not
    misleading. Each of the consolidated balance sheets included in or
    incorporated by reference into Parent's Reports (including the related notes
    and schedules) fairly presents the consolidated financial position of Parent
    and its Subsidiaries as of its date and each of the consolidated statements
    of income, shareholders' investment and cash flows included in or
    incorporated by reference into Parent's Reports (including any related notes
    and schedules) fairly presents the consolidated results of operations,
    statement of shareholders' investment and cash flows, as the case may be, of
    Parent and its Subsidiaries for the periods set forth therein (subject, in
    the case of unaudited statements, to the absence of notes (to the extent
    permitted by the rules applicable to Form 10-Q) and to normal year-end audit
    adjustments that will not be material in amount or effect), in each case in
    accordance with GAAP consistently applied during the periods involved,
    except as may be noted therein. Except as set forth in Section 5.2(e) of the
    Parent Disclosure Letter, to Parent's knowledge, as of the date of this
    Agreement, no Person or "group" "beneficially owns" 5% or more of Parent's
    outstanding voting securities, with the terms "beneficially owns" and
    "group" having the meanings ascribed to them under Rule 13d-3 and Rule 13d-5
    under the Exchange Act.

    (f)  ABSENCE OF CERTAIN CHANGES.  Except as disclosed in Parent's Reports
    filed prior to the date of this Agreement or as expressly contemplated by
    this Agreement, since the Audit Date, there has not been: (i) any change in
    the financial condition, liabilities and assets (taken together), business
    or results of operations of Parent and its Subsidiaries, except those
    changes that are not, individually or in the aggregate, reasonably likely to
    have a Material Adverse Effect on Parent; (ii) any damage, destruction or
    other casualty loss with respect to any asset or property owned, leased or
    otherwise used by Parent or any of its Subsidiaries, whether or not covered
    by insurance, which damage, destruction or loss is reasonably likely,
    individually or in the aggregate, to have a Material Adverse Effect on
    Parent; or (iii) any change by Parent in accounting principles, practices or
    methods, except as required by GAAP.

    (g)  ACCOUNTING AND TAX MATTERS.  Neither Parent nor any of its Subsidiaries
    or Pooling Affiliates has taken or agreed to take any action, nor do
    Parent's executive officers have any actual knowledge of any fact or
    circumstance, that would prevent Parent from accounting for the business
    combination to be effected by the Merger as a "pooling-of-interests" in
    accordance with the

                                      A-25
<PAGE>
    Pooling Requirements or prevent the Merger and the other transactions
    contemplated by this Agreement from qualifying as a "reorganization" within
    the meaning of Section 368(a) of the Code.

    (h)  CONTINUATION OF OPERATIONS.  Parent intends to cause the Surviving
    Corporation to continue to maintain significant operations in the Silicon
    Valley area of California.

                                    ARTICLE VI.
                                     COVENANTS

    6.1  INTERIM OPERATIONS. Except as set forth in the corresponding sections
or subsections of the Company Disclosure Letter and the Parent Disclosure
Letter, as appropriate:

       (a)  The Company covenants and agrees as to itself and its Subsidiaries
       that, after the date of this Agreement and prior to the Effective Time
       (unless Parent shall otherwise approve in writing and except as (x)
       otherwise required by applicable Law, in which case, the Company shall
       provide Parent with prior reasonable notice of such requirement, or (y)
       expressly contemplated by this Agreement):

           (i)  Its business and that of its Subsidiaries shall be conducted
           only in the ordinary and usual course and, to the extent consistent
           therewith, it and its Subsidiaries shall use their reasonable best
           efforts to preserve their business organizations intact and maintain
           their existing relations and goodwill with customers, suppliers,
           regulators, distributors, creditors, lessors, employees and business
           associates; PROVIDED, HOWEVER, that no action by the Company or its
           Subsidiaries with respect to matters specifically addressed by any
           other provision of this Section 6.1(a) shall be deemed a breach of
           this Section 6.1(a)(i) unless such action would constitute a breach
           of one or more such other provisions;

           (ii)  It shall not: (A) amend its certificate of incorporation or
           bylaws; (B) split, combine, subdivide or reclassify its outstanding
           shares of capital stock; (C) declare, set aside or pay any dividend
           payable in cash, stock or property in respect of any capital stock;
           or (D) repurchase, redeem or otherwise acquire, except in connection
           with commitments existing as of the date of this Agreement under the
           Company Stock Plans but subject to the Company's obligations under
           subparagraph (iii) below, or permit any of its Subsidiaries to
           purchase or otherwise acquire, any shares of its capital stock or any
           securities convertible into or exchangeable or exercisable for any
           shares of its capital stock;

           (iii)  Neither it nor any of its Subsidiaries shall take any action
           that would prevent the Merger from qualifying for
           "pooling-of-interests" accounting treatment in accordance with the
           Pooling Requirements or as a "reorganization" within the meaning of
           Section 368(a) of the Code or that would cause any of its
           representations and warranties in this Agreement to become untrue in
           any material respect;

           (iv)  Neither it nor any of its ERISA Affiliates shall: (A)
           accelerate, amend or change the period of exercisability of or
           terminate, establish, adopt, enter into, make any new grants or
           awards of stock-based compensation or other benefits under any
           Compensation and Benefit Plans including expanding participation in
           any severance pay plan; (B) amend or otherwise modify any
           Compensation and Benefit Plans; or (C) increase the salary, wage,
           bonus or other compensation of any directors, officers or employees,
           except, in the case of (A), (B) and (C), (x) for grants or awards to
           employees below the level of Vice President of it or its Subsidiaries
           under existing Compensation and Benefit Plans in such amounts and on
           such terms as are consistent with past practice, (y) in the normal
           and usual course of its business (which may include normal periodic
           performance reviews and

                                      A-26
<PAGE>
           related compensation and benefit increases and the provision of
           individual Company Compensation and Benefit Plans consistent with
           past practice for promoted or newly hired employees below the level
           of Vice President on terms consistent with past practice), or (z) for
           actions necessary to satisfy existing contractual obligations under
           Compensation and Benefit Plans existing as of the date of this
           Agreement or as required under the terms of this Agreement; PROVIDED,
           that it shall not take such action unless it shall have provided
           Parent with prior reasonable notice;

           (v)  Neither it nor any of its Subsidiaries shall incur, repay or
           retire prior to maturity or refinance any indebtedness for borrowed
           money or guarantee any such indebtedness or issue, sell, repurchase
           or redeem prior to maturity any debt securities or warrants or rights
           to acquire any debt securities or guarantee any debt securities of
           others, in all such cases in excess of, in the aggregate, $10,000,000
           plus amounts equal to any existing indebtedness described in Section
           4.5 that the Company is required to repurchase prior to the Effective
           Time;

           (vi)  Neither it nor any of its Subsidiaries shall make any capital
           expenditures in an aggregate amount in excess of the aggregate amount
           reflected in the Company's capital expenditure budget for the fiscal
           year ending December 31, 1999, a copy of which has been provided to
           Parent;

           (vii)  Neither it nor any of its Subsidiaries shall issue, deliver,
           sell, pledge or encumber shares of any class of its capital stock or
           any securities convertible or exchangeable into, any rights, warrants
           or options to acquire, or any bonds, debentures, notes or other debt
           obligations having the right to vote or convertible or exercisable
           for any such shares except Company Shares issued pursuant to options
           and other awards outstanding on the date of this Agreement under the
           Company Stock Plans or otherwise permitted by Section 6.1(a)(iv);

           (viii)  Neither it nor any of its Subsidiaries shall authorize,
           propose or announce an intention to authorize or propose, or enter
           into an agreement with respect to, any merger, consolidation or
           business combination (other than the Merger), or any purchase, sale,
           lease, license or other acquisition or disposition of any business or
           of a material amount of assets or securities;

           (ix)  It shall not make any material change in its accounting
           policies or procedures, other than any such change that is required
           by GAAP, or revalue any assets, including, without limitation,
           writing down the value of material inventory or writing off notes or
           accounts receivable in a material amount other than as required by
           GAAP;

           (x)  It shall not release, assign, settle or compromise any material
           claims or litigation or make any material tax election or settle or
           compromise any material United States federal, state, local or
           foreign tax liability; and

           (xi) Neither it nor any of its Subsidiaries shall authorize or enter
           into any agreement to violate any of the foregoing.

       (b) Parent covenants and agrees as to itself and its Subsidiaries that,
       after the date of this Agreement and prior to the Effective Time (unless
       the Company shall otherwise approve in writing and except as (x)
       otherwise required by applicable Law, in which case, Parent shall provide
       the Company with prior reasonable notice of such requirement, or (y)
       expressly contemplated by this Agreement):

           (i) It shall remain principally a diversified health care products
           and services company;

                                      A-27
<PAGE>
           (ii) It shall not: (A) reclassify its shares of capital stock or (B)
           declare, set aside or pay any dividend payable in cash, stock (other
           than Parent Common Stock) or property in respect of any capital
           stock, except (x) for regular quarterly cash dividends or (y) for a
           dividend that would be received by the holders of the Company Common
           Stock on an equivalent basis per share of Parent Common Stock after
           the Effective Time;

           (iii) Neither it nor any of its Subsidiaries shall take any action
           that would prevent the Merger from qualifying for
           "pooling-of-interests" accounting treatment in accordance with the
           Pooling Requirements or as a "reorganization" within the meaning of
           Section 368(a) of the Code or that would cause any of its
           representations and warranties in this Agreement to become untrue in
           any material respect;

           (iv) Neither it nor any of its Subsidiaries shall authorize, propose
           or announce an intention to authorize or propose, or enter into an
           agreement with respect to, any merger, consolidation or business
           combination, or any purchase, sale, lease, license or other
           acquisition of any business or a material amount of assets or
           securities, in all such cases, with any of the entities identified in
           Section 6.1(b) of the Company Disclosure Letter; and

           (v) Neither it nor any of its Subsidiaries shall authorize or enter
           into any agreement to violate any of the foregoing.

       (c) Parent and the Company agree that any written approval of Parent or
       of the Company obtained under Section 6.1(a) or 6.1(b) must be signed on
       behalf of the appropriate party by the Chief Executive Officer or Chief
       Financial Officer of Parent or of the Company or Senior Vice President,
       Pharmaceutical Operations of Parent or Group Vice President, ALZA
       Technologies, of the Company.

    6.2  ACQUISITION PROPOSALS.

       (a) The Company agrees that neither it nor any of its Subsidiaries nor
       any of the officers and directors of it or its Subsidiaries shall, and
       that it shall direct and use its best efforts to cause its and its
       Subsidiaries' employees, agents and representatives (including any
       investment banker, attorney or accountant retained by it or any of its
       Subsidiaries) (the Company, its Subsidiaries and their officers,
       directors, employees, agents and representatives being referred to as the
       "COMPANY REPRESENTATIVES") not to, directly or indirectly, initiate,
       solicit, encourage or otherwise facilitate any inquiries or the making of
       any proposal or offer with respect to a merger, reorganization, share
       exchange, consolidation, business combination, recapitalization,
       liquidation, dissolution or similar transaction involving it, or any
       purchase or sale of the consolidated assets (including stock of its
       Subsidiaries) of it or any of its Subsidiaries, taken as a whole, having
       an aggregate value equal to 10% or more of its market capitalization, or
       any purchase or sale of, or tender or exchange offer for, 10% or more of
       its or any of its Subsidiaries' equity securities (any such proposal or
       offer being hereinafter referred to as an "ACQUISITION PROPOSAL"). The
       Company further agrees that neither it nor any of its Subsidiaries nor
       any of the officers and directors of it or its Subsidiaries shall, and
       that it shall direct and use its best efforts to cause the Company
       Representatives not to, directly or indirectly, have any discussion with
       or provide any confidential information or data to any Person relating to
       or in contemplation of an Acquisition Proposal or engage in any
       negotiations concerning an Acquisition Proposal, or otherwise facilitate
       any effort or attempt to make or implement an Acquisition Proposal;
       PROVIDED, HOWEVER, that nothing contained in this Agreement shall prevent
       either the Company or its Board of Directors from: (A) complying with
       Rule 14d-9 and Rule 14e-2 promulgated under the Exchange Act with regard
       to an Acquisition Proposal; (B) engaging in any discussions or
       negotiations with or providing any information to, any Person in response
       to an unsolicited bona fide written Acquisition Proposal by any such

                                      A-28
<PAGE>
       Person; or (C) subject to the obligation of the Company pursuant to
       Section 6.4 to duly convene a Stockholders Meeting at which a vote of the
       stockholders of the Company shall be taken regarding the adoption of this
       Agreement and the approval of the transactions contemplated by this
       Agreement, recommending such an unsolicited bona fide written Acquisition
       Proposal to the stockholders of the Company if, and only to the extent
       that, with respect to the actions referred to in clauses (B) or (C), (i)
       the Board of Directors of the Company concludes in good faith (after
       consultation with its outside legal counsel and its financial advisor)
       that such Acquisition Proposal is reasonably capable of being completed,
       taking into account all legal, financial, regulatory and other aspects of
       the proposal and the Person making the proposal, and would, if
       consummated, result in a transaction more favorable to the Company's
       stockholders from a financial point of view than the transaction
       contemplated by this Agreement (a "SUPERIOR PROPOSAL"), (ii) the Board of
       Directors of the Company determines in good faith after consultation with
       outside legal counsel that the failure to take such action would result
       in the reasonable likelihood that the Board of Directors would breach its
       fiduciary duties to the Company's stockholders under applicable Law and
       (iii) prior to providing any information or data to any Person in
       connection with an Acquisition Proposal by any such Person, the Board of
       Directors of the Company shall receive from such Person an executed
       confidentiality agreement on terms substantially similar to those
       contained in the confidentiality agreement previously entered into
       between Parent and the Company in connection with their consideration of
       the Merger; PROVIDED, that such confidentiality agreement shall contain
       terms that allow the Company to comply with its obligations under this
       Section 6.2.

       (b) The Company agrees that it will immediately cease and cause to be
       terminated any existing activities, discussions or negotiations with any
       parties conducted heretofore with respect to any Acquisition Proposal.
       The Company agrees that it will take the necessary steps to promptly
       inform each Company Representative of the obligations undertaken in
       Section 6.2(a). The Company agrees that it will notify Parent promptly,
       but in any event within twenty-four (24) hours, if any such inquiries,
       proposals or offers are received by, any such information is requested
       from, or any such discussions or negotiations are sought to be initiated
       or continued with, any Company Representative indicating, in connection
       with such notice, the name of such Person making such inquiry, proposal,
       offer or request and the substance of any such inquiries, proposals or
       offers. The Company thereafter shall keep Parent informed, on a timely
       basis, of the status and terms of any such inquiries, proposals or offers
       and the status of any such discussions or negotiations. The Company also
       agrees that it will promptly request each Person that has heretofore
       executed a confidentiality agreement in connection with its consideration
       of any Acquisition Proposal to return all confidential information
       heretofore furnished to such Person by or on behalf of the Company or any
       of its Subsidiaries.

    6.3  INFORMATION SUPPLIED.  The Company and Parent each agrees, as to itself
and its Subsidiaries, that none of the information supplied or to be supplied by
it or its Subsidiaries for inclusion or incorporation by reference in (i) the
Registration Statement on Form S-4 to be filed with the SEC by Parent in
connection with the issuance of shares of Parent Common Stock in the Merger
(including the joint proxy statement and prospectus (the "PROSPECTUS/PROXY
STATEMENT") constituting a part thereof) (the "S-4 REGISTRATION STATEMENT")
will, at the time the S-4 Registration Statement becomes effective under the
Securities Act, and (ii) the Prospectus/Proxy Statement and any amendment or
supplement thereto will, at the date of mailing to stockholders and at the time
of the meeting of stockholders of the Company to be held in connection with the
Merger, in any such case, contain any untrue statement of a material fact or
omit to state any material fact required to be stated therein or necessary in
order to make the statements therein, in light of the circumstances under which
they were made, not misleading. If at any time prior to the Effective Time any
information relating to Parent or the

                                      A-29
<PAGE>
Company, or any of their respective Affiliates, officers or directors, is
discovered by Parent or the Company which should be set forth in an amendment or
supplement to any of the S-4 Registration Statement or the Prospectus/Proxy
Statement, so that any of such documents would not include any misstatement of a
material fact or would omit to state any material fact required to be stated
therein or necessary to make the statements therein, in the light of the
circumstances under which they were made, not misleading, the party which
discovers such information shall promptly notify the other parties to this
Agreement and an appropriate amendment or supplement describing such information
shall be promptly filed by the appropriate party with the SEC and, to the extent
required by law, disseminated to the stockholders of the Company.

    6.4  STOCKHOLDERS MEETING.  Subject to Section 8.3(b), the Company will
take, in accordance with applicable Law and its certificate of incorporation and
bylaws, all action necessary to convene a meeting of holders of Company Shares
(the "STOCKHOLDERS MEETING") as promptly as practicable after the S-4
Registration Statement is declared effective to consider and vote upon the
adoption of this Agreement. The Company's Board of Directors shall (i) recommend
that the stockholders of the Company adopt this Agreement and thereby approve
the transactions contemplated by this Agreement and (ii) take all lawful action
(including the solicitation of proxies) to solicit such adoption; PROVIDED,
HOWEVER, that the Company's Board of Directors may, at any time prior to the
Effective Time, withdraw, modify or change any such recommendation to the extent
that the Company's Board of Directors determines in good faith, after
consultation with outside legal counsel, that such withdrawal, modification or
change of its recommendation is required by its fiduciary duties to the
Company's stockholders under applicable Law; PROVIDED, FURTHER, that, subject to
Section 8.3(b), regardless of whether the Company's Board of Directors has
withdrawn, modified or changed its recommendation to the stockholders regarding
the adoption of this Agreement or the approval of the transactions contemplated
by this Agreement, the Company shall as promptly as practicable after the S-4
Registration Statement is declared effective duly convene and complete the
Stockholders Meeting and cause a vote of the stockholders to be taken at such
Stockholders Meeting regarding the adoption of this Agreement and the approval
of the transactions contemplated by this Agreement.

    6.5  FILINGS; OTHER ACTIONS; NOTIFICATION.

    (a) Parent and the Company shall promptly prepare and file with the SEC the
    Prospectus/Proxy Statement, and Parent shall prepare and file with the SEC
    the S-4 Registration Statement as promptly as practicable. Parent and the
    Company each shall use its reasonable best efforts to have the S-4
    Registration Statement declared effective under the Securities Act as
    promptly as practicable after such filing, and promptly thereafter mail the
    Prospectus/Proxy Statement to the stockholders of the Company. Parent shall
    also use its reasonable best efforts to obtain prior to the effective date
    of the S-4 Registration Statement all necessary state securities law or
    "blue sky" permits and approvals required in connection with the Merger and
    the other transactions contemplated by this Agreement and will pay all
    expenses incident thereto.

    (b) The Company and Parent each shall use its respective reasonable best
    efforts to cause to be delivered to the other party and its directors
    letters of its independent auditors, dated (i) the date on which the S-4
    Registration Statement shall become effective and (ii) the Closing Date, and
    addressed to the other party and its directors, in form and substance
    customary for "comfort" letters delivered by independent public accountants
    in connection with registration statements similar to the S-4 Registration
    Statement.

    (c) The Company and Parent shall cooperate with each other and, subject to
    Sections 6.5(d) and (e), use (and shall cause their respective Subsidiaries
    to use) their respective reasonable best efforts (i) to take or cause to be
    taken all actions, and do or cause to be done all things, necessary, proper
    or advisable on their part under this Agreement and applicable Laws to
    consummate and make effective the Merger and the other transactions
    contemplated by this Agreement as soon as

                                      A-30
<PAGE>
    practicable, including (A) obtaining opinions of their respective
    accountants and attorneys referred to in Section 6.5(b) and Article VII of
    this Agreement, (B) preparing and filing as promptly as practicable all
    documentation to effect all necessary applications, notices, petitions,
    filings and other documents including, without limitation, filings under the
    HSR Act, (C) instituting court actions and other proceedings necessary to
    obtain the approvals required to consummate the Merger or the other
    transactions contemplated by this Agreement or defending or otherwise
    opposing all court actions and other proceedings instituted by a
    Governmental Entity or other Person under the Competition Laws or otherwise
    for purposes of preventing the consummation of the Merger and the other
    transactions contemplated by this Agreement, and (D) to prepare prior to,
    and to execute and deliver at, the Closing supplements to the 5% Debenture
    Indenture, the 5- 1/4% Debenture Indenture and the Warrant Agreement in
    accordance with Sections 4.5(a), (b) and (c) and (ii) to obtain as promptly
    as practicable all consents, registrations, approvals, permits and
    authorizations necessary or advisable to be obtained from any third party
    and/or any Governmental Entity in order to consummate the Merger and the
    other transactions contemplated by this Agreement. Subject to applicable
    Laws relating to the exchange of information, Parent and the Company shall
    have the right to review in advance, and to the extent practicable each will
    consult the other on, all the information relating to Parent or the Company,
    as the case may be, and any of their respective Subsidiaries, that appear in
    any filing made with, or written materials submitted to, any third party
    and/or any Governmental Entity in connection with the Merger and the other
    transactions contemplated by this Agreement. In exercising the foregoing
    right, each of the Company and Parent shall act reasonably and as promptly
    as practicable.

    (d) Notwithstanding anything to the contrary in this Agreement, (i) the
    Company shall not, without Parent's prior written consent, commit to any
    divestitures, licenses or hold separate or similar arrangements (or allow
    its Subsidiaries to commit to any divestitures, licenses or hold separate or
    similar arrangements), and the Company shall commit to, and shall use
    reasonable best efforts to effect (and shall cause its Subsidiaries to
    commit to and use reasonable best efforts to effect), any such divestitures,
    licenses or hold separate or similar arrangements as Parent shall request in
    order to obtain approval of the transactions contemplated by this Agreement
    under applicable Competition Laws and (ii) except as set forth in Section
    6.5(e), neither Parent nor any of its Subsidiaries shall be required to
    agree (with respect to (x) Parent or its Subsidiaries or (y) the Company or
    its Subsidiaries) to any divestitures, licenses or hold separate or similar
    arrangements in order to obtain approval of the transactions contemplated by
    this Agreement under applicable Competition Laws if such divestitures,
    licenses or arrangements would reasonably be expected to have a Material
    Adverse Effect on Parent or the Company or a material adverse effect on the
    expected benefits of the Merger to Parent.

    (e) Notwithstanding anything to the contrary in this Agreement, nothing in
    this Section 6.5 or any other part of this Agreement shall require Parent to
    refrain from entering into any agreement with respect to, or issuing Parent
    Common Stock or other consideration in connection with, a business
    combination with, or an acquisition of, all or part of a third party (a
    "SUBSEQUENT TRANSACTION"), and such actions by Parent shall not cause a
    breach of this Agreement, except that Parent shall not, prior to the
    Effective Time, enter into any agreement or understanding providing for any
    business combination with or an acquisition of a majority of the stock or
    assets of, any of the entities identified in Section 6.1(b) of the Company
    Disclosure Letter. In the event of a Subsequent Transaction, Parent shall
    agree to any divestitures, licenses or hold separate or similar arrangements
    necessary in order to obtain approval of the transactions contemplated by
    this Agreement under applicable Competition Laws that would not otherwise
    have been required in order to obtain such approval but for the Subsequent
    Transaction.

    (f) The Company and Parent each shall, upon request by the other, furnish
    the other with all information concerning itself, its Subsidiaries,
    directors, officers and stockholders and such other

                                      A-31
<PAGE>
    matters as may be reasonably necessary or advisable in connection with the
    Prospectus/Proxy Statement, the S-4 Registration Statement or any other
    statement, filing, notice or application made by or on behalf of Parent, the
    Company or any of their respective Subsidiaries to any third party and/or
    any Governmental Entity in connection with the Merger and the transactions
    contemplated by this Agreement.

    (g) The Company and Parent each shall keep the other apprised of the status
    of matters relating to completion of the transactions contemplated by this
    Agreement, including promptly furnishing the other with copies of notice or
    other communications received by Parent or the Company, as the case may be,
    or any of its Subsidiaries, from any third party and/or any Governmental
    Entity with respect to the Merger and the other transactions contemplated by
    this Agreement. Each of the Company and Parent shall give prompt notice to
    the other of any change that is reasonably likely to result in a Material
    Adverse Effect on it or of any failure of any conditions to the other
    party's obligations to effect the Merger set forth in Article VII.

    (h) The Company will promptly provide Parent with copies of any
    communication that is issued, prepared or otherwise becomes available from
    the date of this Agreement until the Effective Time which bears
    significantly and adversely upon the regulatory status of the Products or
    the facilities of the Company or any of its Subsidiaries or the facilities
    of the material suppliers of the Company (including its Subsidiaries),
    including, without limitation, any warning letter, notice of violation,
    approval or non-approval letter/order or withdrawal letter/order from a
    Governmental Entity respecting such facilities or Products.

    (i) Parent agrees to reduce (if necessary) the number of "tainted treasury
    shares" (within the contemplation of the Pooling Requirements) attributable
    to Parent such that the attribution to Parent of "tainted treasury shares"
    under the Pooling Requirements shall not prevent Parent from accounting for
    the business combination to be effected by the Merger as a
    "pooling-of-interests" in accordance with the Pooling Requirements by the
    date that is three business days after all of the conditions set forth in
    Article VII other than Section 7.1(e) have been satisfied or, if applicable,
    waived.

    6.6  ACCESS; CONSULTATION.  Upon reasonable notice, and except as may be
prohibited by applicable Law, the Company shall (and shall cause its
Subsidiaries to) afford Parent's employees, agents and representatives
(including any investment banker, attorney or accountant retained by Parent or
any of its Subsidiaries) reasonable access, during normal business hours
throughout the period prior to the Effective Time, to the Company's properties,
books, contracts and records and, during such period, the Company shall (and
shall cause its Subsidiaries to) furnish promptly to Parent all information
concerning the Company's business, properties and personnel as may reasonably be
requested; provided that no investigation pursuant to this Section 6.6 shall
affect or be deemed to modify any representation or warranty made by the Company
under this Agreement; and provided, further, that the foregoing shall not
require the Company to permit any inspection, or to disclose any information,
that in the reasonable judgment of the Company would result in the disclosure of
any trade secrets of third parties or violate any of the Company's obligations
with respect to confidentiality if the Company shall have used all reasonable
efforts to obtain the consent of such third party to such inspection or
disclosure. All requests for information made pursuant to this Section 6.6 shall
be directed to an executive officer of the Company or such Person as may be
designated by any such executive officer, as the case may be. Parent will hold
any such information that is non-public in confidence in accordance with the
Confidentiality Agreement.

    6.7  AFFILIATES.

    (a)  Each of the Company and Parent shall deliver to the other a letter
    identifying all Persons whom such party believes to be, at the date of the
    Stockholders Meeting, affiliates of such party for purposes of applicable
    interpretations regarding use of the "pooling-of-interests" accounting

                                      A-32
<PAGE>
    method ("POOLING AFFILIATES") and, in the case of the Company, affiliates of
    the Company for purposes of Rule 145 under the Securities Act ("RULE 145
    AFFILIATES"). Each of the Company and Parent shall use all reasonable
    efforts to cause each Person who is identified as a Pooling Affiliate or
    Rule 145 Affiliate in the letter referred to above to deliver to Parent
    promptly after execution of this Agreement a written agreement, in the form
    attached as EXHIBIT A, in the case of a Pooling Affiliate or Rule 145
    Affiliate of the Company (the "COMPANY AFFILIATE'S LETTER"), and EXHIBIT B,
    in the case of a Pooling Affiliate of Parent (the "PARENT AFFILIATE'S
    LETTER"). Prior to the Effective Time, each of the Company and Parent shall
    use all reasonable efforts to cause each additional Person who is identified
    as a Pooling Affiliate or Rule 145 Affiliate after the date of the
    Stockholders Meeting to execute the applicable written agreement as set
    forth in this Section 6.7, as soon as practicable after such Person is
    identified.

    (b) Shares of Parent Common Stock issued to Pooling Affiliates of the
    Company in exchange for Company Shares shall not be transferable until such
    time as financial results covering at least 30 days of combined operations
    of Parent and the Company shall have been published within the meaning of
    Section 201.01 of the SEC's Codification of Financial Reporting Policies,
    regardless of whether each such Pooling Affiliate has provided the written
    agreement referred to in this Section, except to the extent permitted by,
    and in accordance with, SEC Accounting Series Release 135 and SEC Staff
    Accounting Bulletins 65 and 76. Any Company Shares held by any such Pooling
    Affiliate shall not be transferable, regardless of whether such Pooling
    Affiliate has provided the applicable written agreement referred to in this
    Section, if such transfer, either alone or in the aggregate with other
    transfers by Pooling Affiliates, would preclude Parent's ability to account
    for the business combination to be effected by the Merger as a pooling of
    interests. The Company shall not register the transfer of any Certificate
    unless such transfer is made in compliance with the foregoing.

    6.8  STOCK EXCHANGE LISTING.  To the extent they are not already listed,
Parent shall use its reasonable best efforts to cause the shares of Parent
Common Stock to be issued in the Merger to be approved for listing on the NYSE
and on all other stock exchanges on which shares of Parent Common Stock are then
listed, subject to official notice of issuance, prior to the Closing Date.

    6.9  PUBLICITY.  The initial press release with respect to the Merger shall
be a joint press release. Thereafter, unless otherwise required by applicable
Law or pursuant to any listing agreement with or rules of a securities exchange,
the Company and Parent shall consult with each other prior to issuing any press
releases or otherwise making public announcements with respect to the Merger and
the other transactions contemplated by this Agreement and prior to making any
filings with any third party and/ or any Governmental Entity (including any
securities exchange) with respect thereto.

    6.10  EMPLOYEE BENEFITS.

    (a)  STOCK OPTIONS.

       (i)  At the Effective Time, each outstanding option to purchase Company
       Shares (a "COMPANY OPTION") under the Company Stock Plans, whether vested
       or unvested, shall be converted to an option to acquire, on the same
       terms and conditions as were applicable under such Company Option, the
       same number of shares of Parent Common Stock as the holder of such
       Company Option would have been entitled to receive pursuant to the Merger
       had such holder exercised such Company Option in full immediately prior
       to the Effective Time (rounded down to the nearest whole number) (a
       "SUBSTITUTE OPTION"), at an exercise price per share (rounded up to the
       nearest whole cent) equal to (y) the aggregate exercise price for the
       Company Shares otherwise purchasable pursuant to such Company Option
       divided by (z) the number of full shares of Parent Common Stock deemed
       purchasable pursuant to such Company Option in accordance with the
       foregoing. Notwithstanding the foregoing, each purchase right granted
       under the Company's Employee Stock Purchase Plan or the Company's
       Supplemental Employee Stock Purchase Plan (the "PURCHASE PLANS") that is
       outstanding at the

                                      A-33
<PAGE>
       Effective Time shall be converted to a right to acquire upon the same
       terms and conditions as were applicable to such right immediately before
       the Effective Time, that number of shares (rounded down to the nearest
       whole share) of Parent Common Stock equal to the Exchange Ratio
       multiplied by the number of Company Shares for which such purchase right
       would otherwise have been exercisable determined as of the relevant grant
       date under the applicable Purchase Plan at a purchase price per share
       equal to 85% of the lower of (A) the fair market value of a Company Share
       on the relevant grant date divided by the Exchange Ratio or (B) the fair
       market value of a share of Parent Common Stock on the relevant purchase
       date.

       (ii)  As promptly as practicable after the Effective Time, the Surviving
       Corporation shall deliver to the participants in the Company Stock Plans
       appropriate notices setting forth such participants' rights pursuant to
       the Substitute Options.

    (b)  RESTRICTED STOCK.  At the Effective Time, each Company Share which is
    subject to restrictions or forfeiture risks (a "RESTRICTED SHARE") under the
    Company Stock Plans shall be converted to the same number of shares of
    Parent Common Stock as the holder of such Restricted Share would have been
    entitled to receive pursuant to the Merger had the Restricted Share not been
    subject to restrictions or forfeiture risks immediately prior to the
    Effective Time (rounded down to the nearest whole share), which shares of
    Parent Common Stock shall be subject to the same restrictions and forfeiture
    risks as the Restricted Share ("SUBSTITUTE RESTRICTED SHARES").

    (c)  CONVERSION AND REGISTRATION.  At or prior to the Effective Time, the
    Company shall make all necessary arrangements with respect to the Company
    Stock Plans to permit the conversion of the unexercised Company Options into
    Substitute Options and the conversion of Restricted Shares into Substitute
    Restricted Shares pursuant to this Section 6.10 and, within three days of
    the Effective Time, Parent shall use its reasonable best efforts to file
    with the SEC a registration statement on Form S-8 or other appropriate form
    covering shares of Parent Common Stock issuable pursuant to all Substitute
    Options and Substitute Restricted Shares with respect to Parent Common Stock
    and shall use its reasonable best efforts to cause such registration
    statement to become effective as soon as possible after filing and to
    maintain the effectiveness thereof.

    (d)  BENEFITS.  Each Compensation and Benefit Plan shall, as of the
    Effective Time, be the obligation of Parent and the Surviving Corporation.
    For the period beginning on the Effective Date and ending on December 31,
    1999, Parent shall cause the Surviving Corporation to continue in effect the
    Compensation and Benefit Plans as in effect as of the Effective Time;
    PROVIDED, HOWEVER, that nothing in the foregoing provisions of this sentence
    shall (i) prevent Parent or the Surviving Corporation from amending any
    Compensation and Benefit Plan to the extent required by Law, or (ii) require
    Parent or the Surviving Corporation to continue any equity-based or equity-
    related plan. Notwithstanding the foregoing, Parent shall continue the
    Purchase Plans in effect until at least the first purchase date under the
    Purchase Plans following the Effective Time. For periods after December 31,
    1999, employees of the Surviving Corporation shall be eligible to
    participate in employee benefit plans, programs, policies and arrangements
    which provide benefits that, in the aggregate, are materially comparable in
    value to those provided to similarly situated employees of Parent employed
    in the United States.

    (e)  SERVICE CREDIT.  In the event that, at or after the Effective Time,
    employees of the Company and its Subsidiaries become eligible to participate
    in a vacation pay program of Parent or its affiliates, such employees will
    be given credit under that vacation pay program for their service with the
    Company and its Subsidiaries for periods prior to the Effective Time to the
    same extent that such service was taken into account for purposes of the
    vacation pay program for which they were eligible immediately prior to the
    Effective Time.

                                      A-34
<PAGE>
    6.11  EXPENSES.  Whether or not the Merger is consummated, all costs and
expenses incurred in connection with this Agreement and the Merger and the other
transactions contemplated by this Agreement shall be paid by the party incurring
such expense, except that expenses incurred in connection with the filing fee
for the S-4 Registration Statement, printing and mailing the Prospectus/ Proxy
Statement, the S-4 Registration Statement and the filing fees under the HSR Act
and any other Competition Law filings shall be shared equally by Parent and the
Company.

    6.12  INDEMNIFICATION; DIRECTORS' AND OFFICERS' INSURANCE.

    (a)  The Certificate of Incorporation and Bylaws of the Surviving
    Corporation shall contain, and Parent shall cause the Surviving Corporation
    to fulfill and honor, provisions with respect to indemnification and
    exculpation that are substantially identical to those set forth in the
    certificate of incorporation and bylaws of the Company as of the date of
    this Agreement, which provisions shall not be amended, repealed or otherwise
    modified for a period of six years from the Effective Time in any manner
    that would adversely affect the rights thereunder of any of the Indemnified
    Parties. "INDEMNIFIED PARTIES" shall include each person who is or was a
    director, officer or employee of the Company or any Subsidiary of the
    Company at any time before the Effective Time, and each person who serves or
    has in the past served at the request of the Company or any Subsidiary of
    the Company as a director, officer, trustee, partner, fiduciary, employee or
    agent of another corporation, partnership, joint venture, trust, pension or
    other employee benefit plan or enterprise at any time before the Effective
    Time.

    (b)  Any Indemnified Party wishing to claim indemnification under paragraph
    (a) of this Section 6.12 shall promptly notify the Surviving Corporation,
    upon learning of any such claim, action, suit, proceeding or investigation,
    but the failure to so notify shall not relieve the Surviving Corporation of
    any liability it may have to such Indemnified Party if such failure does not
    materially prejudice the Surviving Corporation. The Surviving Corporation
    may, at its own expense: (i) participate in the defense of any claim, suit,
    action or proceeding; or (ii) at any time during the course of any such
    claim, suit, action or proceeding, assume the defense thereof, unless the
    Indemnified Parties (or any of them) determine in good faith (after
    consultation with legal counsel) that there is, under applicable standards
    of professional conduct, a conflict or any significant issue between the
    positions of Parent and such Indemnified Parties, PROVIDED that the
    Surviving Corporation's counsel shall be reasonably satisfactory to the
    Indemnified Parties. If the Surviving Corporation assumes such defense, the
    Indemnified Parties shall have the right (but not the obligation) to
    participate in the defense thereof and to employ counsel, at their own
    expense, separate from the counsel employed by the Surviving Corporation.
    Whether or not the Surviving Corporation chooses to assume the defense of
    any such claim, suit, action or proceeding, all of the parties hereto shall
    cooperate in the defense thereof. If the Surviving Corporation fails to so
    assume the defense thereof, the Indemnified Parties may retain counsel
    reasonably satisfactory to the Surviving Corporation and the Surviving
    Corporation shall pay the reasonable fees and expenses of such counsel
    promptly after statements therefor are received; PROVIDED, FURTHER, that the
    Indemnified Parties on whose behalf expenses are advanced provide (x) a
    written affirmation of their good faith belief that the standard of conduct
    necessary for indemnification under Section 145 of the DGCL has been met,
    and (y) an undertaking to repay such advances if it is ultimately determined
    that such Indemnified Party is not entitled to indemnification under Section
    145 of the DGCL. Neither Parent nor the Surviving Corporation shall be
    liable for any settlement effected without its written consent (which
    consent shall not be unreasonably withheld or delayed); PROVIDED, that, in
    the event that any claim or claims for indemnification are asserted or made
    within such a period of six years after the Effective Time, all rights to
    indemnification in respect of any such claim or claims (and the matters
    giving rise thereto) shall continue until the disposition of any and all
    such claim or claims (and the matters giving rise thereto). The Indemnified
    Parties as a group may retain only one law firm (in addition to local
    counsel) to represent them with respect to a single action unless

                                      A-35
<PAGE>
    any Indemnified Party determines in good faith (after consultation with
    legal counsel) that there is, under applicable standards of professional
    conduct, a conflict on any significant issue between the positions of any
    two or more Indemnified Parties. In the event Parent or the Surviving
    Corporation or any of their respective successors or assigns (i)
    consolidates with or merges into any other Person and shall not be the
    continuing or surviving corporation or entity of such consolidation or
    merger, or (ii) transfers or conveys all or substantially all of its
    properties and assets to any Person, then, and in each such case, to the
    extent necessary to effectuate the purposes of this Section 6.12, proper
    provision shall be made so that the successors and assigns of Parent and the
    Surviving Corporation assume the obligations set forth in this Section 6.12,
    and none of the actions described in clause (i) or (ii) shall be taken until
    such provision is made.

    (c)  Without limiting any of the obligations of Parent or the Surviving
    Corporation set forth elsewhere in this Section 6.12, for a period of six
    years after the Effective Time, Parent shall cause the Surviving Corporation
    to maintain in effect, to the extent available, directors' and officers'
    liability insurance covering those persons who are currently covered by the
    Company's directors' and officers' liability insurance policy on terms
    comparable to those applicable under the policy of directors' and officers'
    liability insurance currently maintained by the Company; PROVIDED, HOWEVER,
    that in no event shall Parent or the Surviving Corporation be required to
    expend in excess of 150% of the annual premium currently paid by the Company
    for such coverage, and that if the annual premiums of such insurance
    coverage exceed such amount, the Surviving Corporation shall be obligated
    instead to obtain a policy with the greatest coverage for a cost not
    exceeding such amount. The provisions of this Section 6.12(c) shall be
    deemed to have been satisfied if prepaid policies have been obtained by the
    Company prior to the Closing, which policies provide such directors and
    officers with coverage for an aggregate period of six years with respect to
    claims arising from facts or events that occurred on or before the Effective
    Time, including, without limitation, in respect of the transactions
    contemplated by this Agreement and for a premium not in excess of the
    aggregate of the premiums set forth in the preceding sentence. If such
    prepaid policies have been obtained by the Company prior to the Closing,
    Parent shall and shall cause the Surviving Corporation to maintain such
    policies in full force and effect, and continue to honor the Company's
    obligations thereunder.

    (d)  Parent shall cause the Surviving Corporation to perform its obligations
    under this Section 6.12 and shall, in addition, guarantee, as co-obligor
    with the Surviving Corporation, the performance of such obligations by the
    Surviving Corporation subject to the limits imposed on the Surviving
    Corporation under the DGCL.

    (e)  The obligations of Parent or the Surviving Corporation under this
    Section 6.12 are subject to the conditions that each Indemnified Party shall
    comply with the reasonable requests of the Surviving Corporation or Parent
    in defending or settling any action hereunder and that any Indemnified Party
    shall approve any proposed settlement of any such action if (i) such
    settlement involves no finding or admission of any liability by any
    Indemnified Party, and (ii) the sole relief provided in connection with such
    settlement is monetary damages that are paid in full by the Surviving
    Corporation or Parent.

    (f)  Parent agrees to pay, or cause the Surviving Corporation to pay, all
    expenses, including reasonable attorneys' fees, that may be incurred by the
    Indemnified Parties in successfully enforcing the indemnity and other rights
    under this Section 6.12.

    (g)  The provisions of this Section 6.12 are intended to be for the benefit
    of, and shall be enforceable by, each of the Indemnified Parties, their
    heirs and their representatives.

    6.13  TAKEOVER STATUTES.  If any Takeover Statute is or may become
applicable to the Merger or the other transactions contemplated by this
Agreement, each of Parent and the Company and their respective Boards of
Directors shall grant such approvals and take such actions as are necessary so
that

                                      A-36
<PAGE>
the Merger and such transactions may be consummated as promptly as practicable
on the terms contemplated by this Agreement or by the Merger and otherwise act
to eliminate or minimize the effects of such statute or regulation on the Merger
or such transactions. The Company's Board of Directors shall take all actions,
including the adoption of any resolutions, as may be necessary or reasonably
requested by Parent to assure that any Charter and Bylaw Provisions are not, and
at the Effective Time will not be, applicable to the Merger and the other
transactions contemplated by this Agreement in any manner that would prevent or
make materially burdensome to Parent the Merger or the other transactions
contemplated by this Agreement.

    6.14  CONFIDENTIALITY.  The Company and Parent each acknowledge and confirm
that it has entered into a Confidentiality Agreement, dated May 24, 1999 (the
"CONFIDENTIALITY AGREEMENT"), and that the Confidentiality Agreement shall
remain in full force and effect in accordance with its terms except for the
provisions of Paragraphs 4, 5 and 11 thereof which shall be of no further force
or effect, in each such case, whether or not the Merger is consummated.

    6.15  TAX-FREE REORGANIZATION.  Parent, Merger Sub, and the Company shall
each use its best efforts to cause the Merger to be treated as a reorganization
with the meaning of Section 368(a) of the Code and to obtain an opinion of its
respective counsel as contemplated by Sections 7.2(c) and 7.3(c), respectively.

                                  ARTICLE VII.
                                   CONDITIONS

    7.1  CONDITIONS TO EACH PARTY'S OBLIGATION TO EFFECT THE MERGER.  The
respective obligation of each party to effect the Merger is subject to the
satisfaction or waiver, if applicable, at or prior to the Effective Time of each
of the following conditions:

    (a)  STOCKHOLDER APPROVAL.  This Agreement shall have been duly adopted by
    holders of Company Shares constituting the Requisite Vote;

    (b)  NYSE LISTING.  The shares of Parent Common Stock issuable to the
    Company stockholders pursuant to this Agreement shall have been approved for
    listing (either before or after the execution of this Agreement) on the NYSE
    upon official notice of issuance;

    (c)  LAWS AND ORDERS.  No Governmental Entity of competent jurisdiction
    shall have enacted, issued, promulgated, enforced or entered any Law
    (whether temporary, preliminary or permanent) that is in effect and
    restrains, enjoins or otherwise prohibits consummation of the Merger or the
    other transactions contemplated by this Agreement or permits consummation of
    the Merger or the other transactions contemplated by this Agreement under
    applicable Competition Laws but, except as provided in Section 6.5(e),
    subject to any divestitures, licenses or hold separate or similar
    arrangements if such divestitures, licenses or hold separate or similar
    arrangements would reasonably be expected to have a Material Adverse Effect
    on Parent or the Company or a material adverse effect on the expected
    benefits of the Merger to Parent (collectively, an "ORDER"), and no
    Governmental Entity shall have instituted, and no authoritative source at a
    Governmental Entity shall have threatened to institute, any proceeding
    seeking any such Order;

    (d)  S-4.  The S-4 Registration Statement shall have become effective under
    the Securities Act. No stop order suspending the effectiveness of the S-4
    Registration Statement shall have been issued, and no proceedings for that
    purpose shall have been initiated or be threatened by the SEC; and

    (e)  POOLING.  Each of Parent and the Company shall have received a letter
    from its independent public accounting firm to the effect that the Merger
    should qualify for "pooling-of-interests" accounting treatment.

                                      A-37
<PAGE>
    7.2  CONDITIONS TO OBLIGATIONS OF PARENT AND MERGER SUB.  The obligations of
Parent and Merger Sub to effect the Merger are also subject to the satisfaction
or waiver by Parent at or prior to the Effective Time of the following
conditions:

    (a)  REPRESENTATIONS AND WARRANTIES.  The representations and warranties of
    the Company set forth in this Agreement (i) to the extent qualified by
    Material Adverse Effect shall be true and correct, (ii) to the extent not
    qualified by Material Adverse Effect shall be true and correct (except that
    this clause (ii) shall be deemed satisfied so long as any failures of such
    representations and warranties to be true and correct, taken together, would
    not reasonably be expected to have a Material Adverse Effect on the Company
    and, solely with respect to Sections 5.1(j) and 5.1(l), would not reasonably
    be expected to have a material adverse effect on the expected benefits of
    the Merger to Parent), and (iii) in Section 5.1(b) shall be true and correct
    within an aggregate of no more than 25,000 shares of Company Common Stock,
    in the case of each of (i), (ii) and (iii), as of the date of this Agreement
    and (except to the extent such representations and warranties speak as of an
    earlier date) as of the Closing Date as though made on and as of the Closing
    Date, and Parent shall have received a certificate signed on behalf of the
    Company by an executive officer of the Company to such effect;

    (b)  PERFORMANCE OF OBLIGATIONS OF THE COMPANY.  The Company shall have
    performed in all material respects all obligations required to be performed
    by it under this Agreement at or prior to the Closing Date, the Company's
    stockholders at the Stockholders Meeting shall have voted to adopt this
    Agreement and to approve the transactions contemplated by this Agreement and
    Parent shall have received a certificate signed on behalf of the Company by
    an executive officer of the Company to such effect;

    (c)  TAX OPINION.  Parent shall have received the opinion of Mayer, Brown &
    Platt, counsel to Parent, dated the Closing Date, and the Company shall have
    received the opinion of Heller Ehrman White & McAuliffe, counsel to the
    Company, dated the Closing Date, in each case to the effect that the Merger
    will be treated for U.S. federal income tax purposes as a reorganization
    within the meaning of Section 368(a) of the Code, and that each of Parent,
    Merger Sub and the Company will be a party to that reorganization within the
    meaning of Section 368(b) of the Code. In rendering such opinions, such
    counsel may rely upon reasonable representations and certificates of Parent,
    Merger Sub and the Company and certain stockholders or shareholders of
    Parent, Merger Sub and the Company; and Parent, Merger Sub and the Company
    will make, and each of them agrees to use its reasonable best efforts to
    cause such of its respective stockholders or shareholders to make, such
    representations and deliver such certificates; and

    (d)  GOVERNMENTAL CONSENTS.  The waiting period applicable to the
    consummation of the Merger under the HSR Act shall have expired or been
    terminated and any material consents to the transactions contemplated under
    this Agreement required under the European Community Merger Control
    Regulation or other applicable Competition Laws, as well as other material
    Company Required Consents and Parent Required Consents, shall have been
    obtained, in each case without requiring any divestitures, licenses or hold
    separate or similar arrangements in order to obtain approval of the
    transactions contemplated by this Agreement under applicable Competition
    Laws if such divestitures, licenses or hold separate or similar arrangements
    would reasonably be expected to have a Material Adverse Effect on Parent or
    the Company or a material adverse effect on the expected benefits of the
    Merger to Parent.

    7.3  CONDITIONS TO OBLIGATION OF THE COMPANY.  The obligation of the Company
to effect the Merger is also subject to the satisfaction or waiver by the
Company at or prior to the Effective Time of the following conditions:

    (a)  REPRESENTATIONS AND WARRANTIES.  The representations and warranties of
    Parent and Merger Sub set forth in this Agreement (i) to the extent
    qualified by Material Adverse Effect shall be true

                                      A-38
<PAGE>
    and correct, and (ii) to the extent not qualified by Material Adverse Effect
    shall be true and correct (except that this clause (ii) shall be deemed
    satisfied so long as any failures of such representations and warranties to
    be true and correct, taken together, would not reasonably be expected to
    have a Material Adverse Effect on Parent), in the case of each of (i) and
    (ii), as of the date of this Agreement and (except to the extent such
    representations and warranties speak as of an earlier date) as of the
    Closing Date as though made on and as of the Closing Date, and the Company
    shall have received a certificate signed on behalf of Parent by an executive
    officer of Parent to such effect;

    (b)  PERFORMANCE OF OBLIGATIONS OF PARENT AND MERGER SUB.  Each of Parent
    and Merger Sub shall have performed in all material respects all obligations
    required to be performed by it under this Agreement at or prior to the
    Closing Date, and the Company shall have received a certificate signed on
    behalf of Parent and Merger Sub by an executive officer of Parent to such
    effect;

    (c)  TAX OPINION.  The Company shall have received the opinion of Heller
    Ehrman White & McAuliffe, counsel to the Company, dated the Closing Date,
    and Parent shall have received the opinion of Mayer, Brown & Platt, counsel
    to Parent, dated the Closing Date, in each case to the effect that the
    Merger will be treated for U.S. federal income tax purposes as a
    reorganization within the meaning of Section 368(a) of the Code, and that
    each of Parent, Merger Sub and the Company will be a party to that
    reorganization within the meaning of Section 368(b) of the Code. In
    rendering such opinions, such counsel may rely upon reasonable
    representations and certificates of Parent, Merger Sub and the Company and
    certain stockholders or shareholders of Parent, Merger Sub and the Company;
    and Parent, Merger Sub and the Company will make, and each of them agrees to
    use its reasonable best efforts to cause such of its respective stockholders
    or shareholders to make, such representations and deliver such certificates;
    and

    (d)  GOVERNMENTAL CONSENTS.  The waiting period applicable to the
    consummation of the Merger under the HSR Act shall have expired or been
    terminated and any material consents to the transactions contemplated under
    this Agreement required under the European Community Merger Control
    Regulation or other applicable Competition Laws, as well as other material
    Company Required Consents and Parent Required Consents, shall have been
    obtained.

                                 ARTICLE VIII.
                                  TERMINATION

    8.1  TERMINATION BY MUTUAL CONSENT.  This Agreement may be terminated and
the Merger may be abandoned at any time prior to the Effective Time, whether
before or after the approval by stockholders of the Company referred to in
Section 7.1(a), by mutual written consent of the Company and Parent, through
action of their respective Boards of Directors.

    8.2  TERMINATION BY EITHER PARENT OR THE COMPANY.  This Agreement may be
terminated and the Merger may be abandoned at any time prior to the Effective
Time by action of the Board of Directors of either Parent or the Company if (i)
the Merger shall not have been consummated prior to December 31, 1999 (the
"TERMINATION DATE"); PROVIDED, HOWEVER, that either party shall have the option
to extend the Termination Date (and all references herein to the Termination
Date shall mean such extended date) for an additional period of time not to
exceed 90 days if the reason that the Merger has not been consummated by such
date is that either (A) the condition set forth in Section 7.2(d) has not been
satisfied due to the lack of expiration or termination of the waiting period
under the HSR Act (the "WAITING PERIOD") or the failure to obtain the necessary
consents and approvals under applicable Competition Laws and Parent or the
Company are still attempting to achieve the expiration or termination of the
Waiting Period or to obtain such necessary consents and approvals under
applicable Competition Laws or are contesting whether the Waiting Period has
expired or been terminated or the refusal of the relevant Governmental Entities
to give such consents or approvals in court or through other applicable
proceedings, or (B) the condition set forth in Section 7.1(c) has not been
satisfied due

                                      A-39
<PAGE>
to any Order that has been enacted, issued, promulgated, enforced or entered by
any Governmental Entity pursuant to applicable Competition Laws or due to the
institution or threatened institution by any Governmental Entity of any
proceeding seeking any such Order pursuant to applicable Competition Laws; (ii)
the Stockholders Meeting shall have been held and completed and the adoption of
this Agreement by the Company's stockholders referred to in Section 7.1(a) shall
not have occurred; or (iii) any Order permanently restraining, enjoining or
otherwise prohibiting consummation of the Merger shall become final and
non-appealable (whether before or after the adoption or approval by the
stockholders of the Company); PROVIDED, that the right to terminate this
Agreement pursuant to clause (i) above shall not be available to any party that
has breached in any material respect its obligations under this Agreement in any
manner that shall have proximately contributed to the failure of the Merger to
be consummated on or before the Termination Date.

    8.3  TERMINATION BY THE COMPANY.

    (a)  This Agreement may be terminated and the Merger may be abandoned at any
    time prior to the Effective Time, whether before or after the adoption of
    this Agreement by the stockholders of the Company referred to in Section
    7.1(a), by action of the Board of Directors of the Company if there has been
    a material breach by Parent or Merger Sub of any representation, warranty,
    covenant or agreement contained in this Agreement which (x) would result in
    a failure of a condition set forth in Section 7.3(a) or 7.3(b) and (y)
    cannot be or is not cured prior to the Termination Date.

    (b)  This Agreement may be terminated and the Merger may be abandoned by the
    Company at any time prior to the Stockholders Meeting if the Board of
    Directors of the Company shall approve a Superior Proposal; PROVIDED,
    HOWEVER, that: (i) the Company shall have complied with Section 6.2; (ii)
    the Board of Directors of the Company shall have reasonably concluded in
    good faith, prior to giving effect to all concessions which may be offered
    the Company by Parent pursuant to clause (iv) below, on the basis of the
    advice of its financial advisors and outside counsel, that such proposal is
    a Superior Proposal; (iii) the Company shall have (A) notified Parent in
    writing of its receipt of such Superior Proposal, (B) further notified
    Parent in such writing that the Company intends to enter into a binding
    agreement for such Superior Proposal subject to clause (iv) below and (C)
    attached the most current written version of such Superior Proposal (or a
    summary containing all material terms and conditions of such Superior
    Proposal) to such notice; and (iv) Parent does not make, within five
    business days after receipt of the Company's written notice pursuant to
    clause (iii) above, an offer that the Board of Directors of the Company
    shall have reasonably concluded in good faith on the basis of the advice of
    its financial advisors and outside counsel is at least as favorable to the
    stockholders of the Company as the Superior Proposal; PROVIDED, FURTHER,
    that it shall be a condition to termination pursuant to this Section 8.3(b)
    that the Company shall have made the payment of the Termination Fee to
    Parent required by Section 8.5(b).

    8.4  TERMINATION BY PARENT.  This Agreement may be terminated and the Merger
may be abandoned at any time prior to the Effective Time, before or after the
approval by the stockholders of the Company referred to in Section 7.1(a) and
before or after the Stockholders Meeting, by action of the Board of Directors of
Parent if:

    (a)  the Board of Directors of the Company shall have (i) withdrawn,
    adversely modified or changed its approval or recommendation of this
    Agreement as a result of the existence of an Acquisition Proposal or a
    publicly announced intention (whether or not conditional) to make an
    Acquisition Proposal, (ii) failed to reconfirm its recommendation of this
    Agreement to the Company's stockholders within 15 business days after a
    written request by Parent to do so as a result of the existence of an
    Acquisition Proposal or a publicly announced intention (whether or not
    conditional) to make an Acquisition Proposal or (iii) approved or
    recommended a Superior Proposal; or

                                      A-40
<PAGE>
    (b)  there has been a material breach by the Company of any representation,
    warranty, covenant or agreement contained in this Agreement which (x) would
    result in a failure of a condition set forth in Section 7.2(a) or 7.2(b) and
    (y) cannot be or is not cured prior to the Termination Date.

    8.5  EFFECT OF TERMINATION AND ABANDONMENT.

    (a)  In the event of termination of this Agreement and the abandonment of
    the Merger pursuant to this Article VIII, this Agreement (other than as set
    forth in Section 9.2) shall become void and of no effect with no liability
    (other than as set forth in Sections 6.11, 6.14 and 8.5(b) or in the proviso
    at the end of this sentence) or obligation on the part of any party to this
    Agreement or of any of its directors, officers, employees, agents, legal or
    financial advisors or other representatives; PROVIDED, HOWEVER, that no such
    termination shall relieve any party to this Agreement from any liability for
    damages resulting from any breach of this Agreement.

    (b)  In the event that (i) an Acquisition Proposal shall have been made to
    the Company or shall have been made directly to stockholders generally or
    any Person shall have publicly announced an intention (whether or not
    conditional) to make an Acquisition Proposal and thereafter (A) the Board of
    Directors of the Company has not withdrawn, adversely modified or changed
    its approval or recommendation of this Agreement, the Stockholders meeting
    is held and completed and the Company's stockholders do not adopt this
    Agreement at the Stockholders Meeting, (B) this Agreement is terminated by
    either Parent or the Company, and (C) within 12 months of the termination of
    this Agreement, the Company enters into a definitive agreement with any
    third party with respect to an Acquisition Proposal or an Acquisition
    Proposal is consummated, (ii) an Acquisition Proposal shall have been made
    to the Company or have been made directly to stockholders generally or any
    Person shall have publicly announced an intention (whether or not
    conditional) to make an Acquisition Proposal and thereafter (A) the Board of
    Directors of the Company has withdrawn, adversely modified or changed its
    approval or recommendation of this Agreement, the Stockholders Meeting is
    held and completed and the Company's stockholders do not adopt this
    Agreement at the Stockholders Meeting and (B) this Agreement is terminated
    by either Parent or the Company (a termination under the circumstances
    described in this clause (ii) being a "MODIFIED RECOMMENDATION STOCKHOLDER
    REJECTION TERMINATION"), (iii) this Agreement is terminated by Parent
    pursuant to Section 8.4(a) or (b) (but, with respect to Section 8.4(b),
    solely with respect to a breach of Section 6.2), or (iv) this Agreement is
    terminated by the Company pursuant to Section 8.3(b), then the Company shall
    pay Parent a fee equal to $210,000,000 (the "TERMINATION FEE"), which amount
    shall be in addition to any expenses to be paid pursuant to Section 6.11,
    and shall be payable by wire transfer of same day funds. The Termination Fee
    required to be paid pursuant to this Section 8.5(b) shall be made prior to,
    and shall be a precondition of, the effectiveness of a termination of this
    Agreement by the Company pursuant to Section 8.3(b) or a Modified
    Recommendation Stockholder Rejection Termination by the Company. Any other
    payment required to be made pursuant to this Section 8.5(b) shall be made to
    Parent not later than two business days after the earliest of (i) the
    entering into of a definitive agreement with respect to, or the consummation
    of, an Acquisition Proposal, as applicable, (ii) a termination pursuant to
    Section 8.4(a) or (b) and (iii) a Modified Recommendation Stockholder
    Rejection Termination by Parent. The Company acknowledges that the
    agreements contained in this Section 8.5(b) are an integral part of the
    transactions contemplated by this Agreement, and that, without these
    agreements, Parent and Merger Sub would not enter into this Agreement.
    Accordingly, if the Company fails to pay promptly the amount due pursuant to
    this Section 8.5(b), and, in order to obtain such payment, Parent or Merger
    Sub commences a suit which results in a judgment against the Company for the
    fee set forth in this paragraph (b), the Company shall pay to Parent or
    Merger Sub its costs and expenses (including attorneys' fees) in connection
    with such suit, together with interest on the amount of the fee at the prime
    rate of Citibank N.A. in effect on the date such payment was required to be
    made.

                                      A-41
<PAGE>
                                  ARTICLE IX.
                           MISCELLANEOUS AND GENERAL

    9.1  CERTAIN DEFINITIONS.  Terms defined elsewhere in this Agreement shall
have the meanings set forth therein for all purposes of this Agreement, unless
otherwise specified to the contrary. The following terms shall have the
following meanings:

    "AFFILIATES" shall have the meaning set forth in Rule 12b-2 under the
Exchange Act.

    "CODE" means the Internal Revenue Code of 1986, as amended.

    "COMPANY'S EXECUTIVE OFFICERS" means the Company's Chief Executive Officer,
Senior Vice Presidents, Group Vice Presidents and Senior Director of
Intellectual Property.

    "COMPETITION LAWS" includes the HSR Act, the European Community Merger
Control Regulation, and any other antitrust or competition Law of the United
States of America, the European Community or any other nation, province,
territory or jurisdiction which must be satisfied or complied with in order to
consummate and make effective the Merger or the other transactions contemplated
by this Agreement.

    "CRESCENDO" means Crescendo Pharmaceuticals Corporation, a Delaware
corporation.

    "DGCL" means the Delaware General Corporation Law.

    "ENVIRONMENTAL LAW" means any Law relating to: (A) the protection,
investigation or restoration of the environment, health, safety, or natural
resources; (B) the handling, use, presence, disposal, release or threatened
release of any Hazardous Substance; or (C) noise, odor, wetlands, pollution,
contamination or any injury or threat of injury to persons or property or
notifications to government agencies or the public in connection with any
Hazardous Substance.

    "ERISA" means the Employee Retirement Income Security Act of 1974, as
amended.

    "ERISA AFFILIATE" means any corporation or trade or business which, together
with the Company, is a member of a controlled group of Persons or a group of
trades or businesses under common control with the Company within the meaning of
Sections 414(b), (c), (m) or (o) of the Code.

    "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

    "FDA" means the U.S. Food and Drug Administration.

    "FDCA" means the Federal Food, Drug and Cosmetic Act, as amended.

    "GAAP" means U.S. generally accepted accounting principles.

    "HAZARDOUS SUBSTANCE" means any substance that is listed, classified or
regulated pursuant to any Environmental Law, including any petroleum product or
by-product, asbestos-containing material, lead-containing paint or plumbing,
polychlorinated biphenyls, electromagnetic fields, microwave transmission,
radioactive materials or radon.

    "HSR ACT" means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as
amended.

    "IRS" means the Internal Revenue Service.

    "LAWS" means any law, statute, ordinance, regulation, judgment, order,
decree, injunction, arbitration award, license, authorization, opinion, agency
requirement or permit of any Governmental Entity or common law.

    "MATERIAL ADVERSE EFFECT" means, with respect to any Person, a material
adverse effect on the financial condition, assets and liabilities (taken
together), results of operations or business of such

                                      A-42
<PAGE>
Person and its Subsidiaries, taken as a whole; PROVIDED, HOWEVER, that none of
the following shall be deemed to constitute and shall not be taken into account
in determining the occurrence of a Material Adverse Effect with respect to a
party: (i) any effect arising from or relating to general business or economic
conditions which does not affect such party in any materially disproportionate
manner; (ii) any effect relating to or affecting, with respect to the Company,
the pharmaceutical industry generally or, with respect to Parent, the health
care products and services industries generally, in either such case, which does
not affect such party in a materially disproportionate manner; (iii) any effect
arising from or relating to the announcement or pendency of the Merger; or (iv)
any effect arising from or relating to change in accounting rules or procedures
announced by the Financial Accounting Standards Board.

    "NYSE" means the New York Stock Exchange.

    "PBGC" means the Pension Benefit Guaranty Corporation.

    "PERMITS" means permits, licenses, franchises, variances, exemptions, orders
and other governmental authorizations, consents and approvals.

    "PERSON" means any individual, corporation (including not-for-profit),
general or limited partnership, limited liability company, joint venture,
estate, trust, association, organization, Governmental Entity or other entity of
any kind or nature.

    "SEC" means the Securities and Exchange Commission.

    "SECURITIES ACT" means the Securities Act of 1933, as amended.

    "SIGNIFICANT INVESTEES" means, with respect to any Person, Significant
Subsidiaries of such Person and any entity in which such Person has an equity
interest of 20% or more excluding, with respect to the Company, Durect
Corporation, ProQuest Investments L.P., TechAMP International L.P. and P/A
Charleston Road LLC.

    "SIGNIFICANT SUBSIDIARIES" with respect to any Person has the meaning set
forth in Rule 1-02(w) of Regulation S-X promulgated pursuant to the Exchange Act
and includes any Subsidiaries that if aggregated would together constitute
Significant Subsidiaries.

    "SUBSIDIARY" means, with respect to any Person, any entity, whether
incorporated or unincorporated, of which at least 50% of the stock, securities
or other ownership interests having by their terms ordinary voting power to
elect at least 50% of the Board of Directors or other persons performing similar
functions is directly or indirectly owned by such Person excluding, with respect
to the Company, P/A Charleston Road LLC, a California limited liability company.

    "TAX" (including, with correlative meaning, the terms "TAXES" and "TAXABLE")
includes all federal, state, local and foreign income, profits, franchise, gross
receipts, environmental, customs duty, capital stock, severance, stamp, payroll,
sales, employment, unemployment, disability, use, property, withholding, excise,
production, value added, occupancy and other taxes, duties or assessments of any
nature whatsoever, together with all interest, penalties and additions imposed
with respect to such amounts and any interest in respect of such penalties and
additions.

    "TAX RETURN" includes all federal, state, local and foreign returns and
reports (including elections, declarations, disclosures, schedules, estimates
and information returns) required to be supplied to a Tax authority relating to
Taxes.

    9.2  SURVIVAL.  Article II, Article III, Article IV and this Article IX
(other than Section 9.5 (Counterparts)), and the agreements of the Company,
Parent and Merger Sub contained in Sections 6.7(b) (Affiliates), 6.10 (Employee
Benefits), 6.11 (Expenses) and 6.12 (Indemnification; Directors' and Officers'
Insurance) shall survive the consummation of the Merger. This Article IX (other
than Section 9.3 (Modification or Amendment), Section 9.4 (Waiver of Conditions)
and

                                      A-43
<PAGE>
Section 9.13 (Assignment)) and the agreements of the Company, Parent and Merger
Sub contained in Section 6.11 (Expenses), Section 6.14 (Confidentiality) and
Section 8.5 (Effect of Termination and Abandonment) shall survive the
termination of this Agreement. All other representations, warranties, covenants
and agreements in this Agreement shall not survive the consummation of the
Merger or the termination of this Agreement.

    9.3  MODIFICATION OR AMENDMENT.  Subject to the provisions of applicable
Law, at any time prior to the Effective Time, the parties to this Agreement may
modify or amend this Agreement, by written agreement executed and delivered by
duly authorized officers of the respective parties.

    9.4  WAIVER OF CONDITIONS.

    (a)  Any provision of this Agreement may be waived prior to the Effective
    Time if, and only if, such waiver is in writing and signed by an authorized
    representative of the party against whom the waiver is to be effective.

    (b)  No failure or delay by any party in exercising any right, power or
    privilege under this Agreement shall operate as a waiver thereof nor shall
    any single or partial exercise thereof preclude any other or further
    exercise thereof or the exercise of any other right, power or privilege.
    Except as otherwise provided in this Agreement, the rights and remedies
    herein provided shall be cumulative and not exclusive of any rights or
    remedies provided by Law.

    9.5  COUNTERPARTS.  This Agreement may be executed in any number of
counterparts, each such counterpart being deemed to be an original instrument,
and all such counterparts shall together constitute the same agreement.

    9.6  GOVERNING LAW AND VENUE; WAIVER OF JURY TRIAL.

    (a)  THIS AGREEMENT SHALL BE DEEMED TO BE MADE IN AND IN ALL RESPECTS SHALL
    BE INTERPRETED, CONSTRUED AND GOVERNED BY AND IN ACCORDANCE WITH THE LAW OF
    THE STATE OF DELAWARE WITHOUT REGARD TO THE CONFLICT OF LAW PRINCIPLES
    THEREOF. The parties hereby irrevocably and unconditionally consent to
    submit to the exclusive jurisdiction of the courts of the State of Delaware
    and of the United States of America located in Wilmington, Delaware (the
    "DELAWARE COURTS") for any litigation arising out of or relating to this
    Agreement and the transactions contemplated by this Agreement (and agree not
    to commence any litigation relating thereto except in such Delaware Courts),
    waive any objection to the laying of venue of any such litigation in the
    Delaware Courts and agree not to plead or claim in any Delaware Court that
    such litigation brought therein has been brought in an inconvenient forum.

    (b)  EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE
    UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES,
    AND THEREFORE EACH SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES
    ANY RIGHT SUCH PARTY MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY
    LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS
    AGREEMENT, OR THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT. EACH PARTY
    CERTIFIES AND ACKNOWLEDGES THAT (i) NO REPRESENTATIVE, AGENT OR ATTORNEY OF
    ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER
    PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING
    WAIVER, (ii) EACH SUCH PARTY UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS
    OF THIS WAIVER, (iii) EACH SUCH PARTY MAKES THIS WAIVER VOLUNTARILY, AND
    (iv) EACH SUCH PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG
    OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 9.6.

                                      A-44
<PAGE>
    9.7  NOTICES.  Notices, requests, instructions or other documents to be
given under this Agreement shall be in writing and shall be deemed given, (i)
three business days following sending by registered or certified mail, postage
prepaid, (ii) when sent if sent by facsimile, provided that a copy of the fax is
promptly sent by U.S. mail, (iii) when delivered, if delivered personally to the
intended recipient, and (iv) one business day later, if sent by overnight
delivery via a national courier service, and in each case, addressed to a party
at the following address for such party:

    If to Parent or Merger Sub:

           Abbott Laboratories
           100 Abbott Park Road
           Abbott Park, Illinois 60064-3500
           Attention: Chief Executive Officer
           Fax: (847) 938-6277

           and

           Abbott Laboratories
           100 Abbott Park Road
           Abbott Park, Illinois 60064-3500
           Attention: General Counsel
           Fax: (847) 938-6277

    with a copy to:

           Scott J. Davis and James T. Lidbury
           Mayer, Brown & Platt
           190 South LaSalle Street
           Chicago, Illinois 60603
           Fax: (312) 701-7711

    and if to the Company:

           ALZA Corporation
           950 Page Mill Road
           Palo Alto, California 94304
           Attention: Chief Executive Officer
           Fax: (650) 496-8819

           and

           ALZA Corporation
           950 Page Mill Road
           Palo Alto, California 94304
           Attention: General Counsel
           Fax: (650) 494-5561

                                      A-45
<PAGE>
with a copy to:

           Sarah A. O'Dowd
           Heller Ehrman White & McAuliffe
           525 University Avenue
           Palo Alto, California 94301
           Fax: (650) 324-0638

           and

           Brian J. McCarthy
           Skadden, Arps, Slate, Meagher & Flom LLP
           300 South Grand Avenue
           Suite 3400
           Los Angeles, California 90071
           Fax: (213) 687-5600

or to such other persons or addresses as may be designated in writing by the
party to receive such notice as provided above.

    9.8  ENTIRE AGREEMENT.  This Agreement (including any exhibits to this
Agreement), the Confidentiality Agreement, the Company Disclosure Letter and the
Parent Disclosure Letter constitute the entire agreement, and supersede all
other prior agreements, understandings, representations and warranties both
written and oral, among the parties with respect to the subject matter of this
Agreement. EACH PARTY TO THIS AGREEMENT AGREES THAT, EXCEPT FOR THE
REPRESENTATIONS AND WARRANTIES CONTAINED IN THIS AGREEMENT, NEITHER PARENT AND
MERGER SUB NOR THE COMPANY MAKES ANY REPRESENTATIONS OR WARRANTIES, AND EACH
HEREBY DISCLAIMS ANY OTHER REPRESENTATIONS OR WARRANTIES MADE BY ITSELF OR ANY
OF ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS, FINANCIAL AND LEGAL ADVISORS OR
OTHER REPRESENTATIVES, WITH RESPECT TO THE EXECUTION AND DELIVERY OF THIS
AGREEMENT OR THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT, NOTWITHSTANDING
THE DELIVERY OR DISCLOSURE TO THE OTHER OR THE OTHER'S REPRESENTATIVES OF ANY
DOCUMENTATION OR OTHER INFORMATION WITH RESPECT TO ANY ONE OR MORE OF THE
FOREGOING.

    9.9  NO THIRD PARTY BENEFICIARIES.  Except as provided in Section 6.10
(Benefits) and Section 6.12 (Indemnification; Directors' and Officers'
Insurance), this Agreement is not intended to confer upon any Person other than
the parties to this Agreement any rights or remedies under this Agreement.

    9.10  OBLIGATIONS OF PARENT AND OF THE COMPANY.  Whenever this Agreement
requires a Subsidiary of Parent to take any action, such requirement shall be
deemed to include an undertaking on the part of Parent to cause such Subsidiary
to take such action. Whenever this Agreement requires a Subsidiary of the
Company to take any action, such requirement shall be deemed to include an
undertaking on the part of the Company to cause such Subsidiary to take such
action and, after the Effective Time, on the part of the Surviving Corporation
to cause such Subsidiary to take such action.

    9.11  SEVERABILITY.  The provisions of this Agreement shall be deemed
severable and the invalidity or unenforceability of any provision shall not
affect the validity or enforceability or the other provisions of this Agreement.
If any provision of this Agreement, or the application thereof to any Person or
any circumstance, is invalid or unenforceable, (a) a suitable and equitable
provision shall be substituted therefor in order to carry out, so far as may be
valid and enforceable, the intent and purpose of such invalid or unenforceable
provision and (b) the remainder of this Agreement and the application of such

                                      A-46
<PAGE>
provision to other Persons or circumstances shall not be affected by such
invalidity or unenforceability, nor shall such invalidity or unenforceability
affect the validity or enforceability of such provision, or the application
thereof, in any other jurisdiction.

    9.12  INTERPRETATION.  The table of contents and headings in this Agreement
are for convenience of reference only, do not constitute part of this Agreement
and shall not be deemed to limit or otherwise affect any of the provisions of
this Agreement. Where a reference in this Agreement is made to a Section or
Exhibit, such reference shall be to a Section of or Exhibit to this Agreement
unless otherwise indicated. Whenever the words "include," "includes" or
"including" are used in this Agreement, they shall be deemed to be followed by
the words "without limitation."

    9.13  ASSIGNMENT.  This Agreement shall not be assignable; PROVIDED,
HOWEVER, that Parent may designate prior to the Effective Time, by written
notice to the Company, another wholly owned direct or indirect Subsidiary to be
a party to the Merger in lieu of Merger Sub, in which event all references in
this Agreement to Merger Sub shall be deemed references to such other Subsidiary
(except with respect to representations and warranties made in this Agreement,
with respect to Merger Sub as of the date of this Agreement) and all
representations and warranties made herein with respect to Merger Sub as of the
date of this Agreement shall also be made with respect to such other Subsidiary
as of the date of such designation. Any assignment in contravention of the
preceding sentence shall be null and void.

    IN WITNESS WHEREOF, this Agreement has been duly executed and delivered by
the duly authorized officers of the parties to this Agreement as of the date
first written above.

<TABLE>
<S>                             <C>  <C>
                                ALZA CORPORATION

                                By:  /s/ ERNEST MARIO
                                     -----------------------------------------
                                     Name: Ernest Mario
                                     Title: Chairman and CEO

                                ABBOTT LABORATORIES

                                By:  /s/ MILES D. WHITE
                                     -----------------------------------------
                                     Name: Miles D. White
                                     Title: Chairman of the Board and Chief
                                     Executive Officer

                                AC MERGER SUB INC.

                                By:  /s/ ARTHUR J. HIGGINS
                                     -----------------------------------------
                                     Name: Arthur J. Higgins
                                     Title: President
</TABLE>

                                      A-47
<PAGE>
                                 EXHIBIT 6.7(A)
                             STOCKHOLDER AGREEMENT

    This STOCKHOLDER AGREEMENT, dated as of June   , 1999 (this "Agreement") is
between ABBOTT LABORATORIES, an Illinois corporation ("Parent"), and the
undersigned stockholder ("Stockholder") of ALZA CORPORATION, a Delaware
corporation (the "Company"). Capitalized terms not otherwise defined in this
Agreement have the meanings ascribed to them in the Merger Agreement (as defined
below).

                                    RECITALS

    A. Parent and the Company have entered into an Agreement and Plan of Merger,
dated as of June 21, 1999 (the "Merger Agreement"), pursuant to which AC Merger
Sub Inc., a Delaware corporation and a wholly owned subsidiary of Parent
("Merger Sub"), will merge with and into the Company (the "Merger"), with the
Company surviving the Merger and becoming a wholly owned subsidiary of Parent;

    B.  Pursuant to the Merger Agreement, at the Effective Time, outstanding
shares of Company Common Stock, including any Company Common Stock owned by
Stockholder, will be converted into the right to receive shares of Parent Common
Stock;

    C.  It is a condition to each party's obligation to effect the Merger that
(i) legal counsel to the Company and Parent shall have delivered their
respective opinions to the effect that the Merger will constitute a
reorganization within the meaning of Section 368(a) of the Internal Revenue Code
of 1986, as amended (the "Code"), and Parent, Merger Sub and the Company each
will be a party to the reorganization within the meaning of Section 368(b) of
the Code, and (ii) the independent public accounting firms for the Company and
Parent shall have delivered their respective opinions to the effect that the
Merger will qualify for pooling-of-interests accounting treatment;

    D. The execution and delivery of this Agreement by Stockholder is a material
inducement to Parent to enter into the Merger Agreement; and

    E.  Stockholder has been advised that Stockholder may be deemed to be an
"affiliate" of the Company, as such term is used (i) for purposes of paragraphs
(c) and (d) of Rule 145 of the Securities and Exchange Commission (the
"Commission") under the Securities Act of 1933, as amended (the "Act"), or (ii)
in the Commission's Accounting Series Releases 130 and 135, as amended, although
nothing contained herein shall be construed as an admission by Stockholder that
Stockholder is in fact an affiliate of the Company.

    NOW, THEREFORE, intending to be legally bound, the parties agree as follows:

    1.  ACKNOWLEDGMENTS BY STOCKHOLDER.  Stockholder acknowledges and
understands that the representations, warranties and covenants made by
Stockholder set forth in this Agreement will be relied upon by Parent, the
Company and their respective affiliates, counsel and accounting firms, and that
substantial losses and damages may be incurred by such persons if Stockholder's
representations, warranties or covenants are breached. Stockholder has carefully
read this Agreement and the Merger Agreement and has consulted with such legal
counsel and financial advisers as Stockholder has deemed appropriate in
connection with the execution of this Agreement.

    2.  COMPLIANCE WITH RULE 145 AND THE ACT.

        (a) Stockholder has been advised that (i) the issuance of shares of
    Parent Common Stock in connection with the Merger is expected to be effected
    pursuant to a Registration Statement filed by Parent on Form S-4, and the
    resale of such shares will be subject to the restrictions set forth in Rule
    145 under the Act unless such shares are otherwise transferred pursuant to
    an effective

                                      A-48
<PAGE>
    registration statement under the Act or an appropriate exemption from
    registration, and (ii) Stockholder may be deemed to be an affiliate of the
    Company. Stockholder accordingly agrees not to sell, pledge, transfer or
    otherwise dispose of any shares of Parent Common Stock issued to Stockholder
    in the Merger unless (i) such sale, pledge, transfer or other disposition is
    made in conformity with the requirements of Rule 145 under the Act, (ii)
    such sale, pledge, transfer or other disposition is made pursuant to an
    effective registration statement under the Act, or (iii) Stockholder
    delivers to Parent a written opinion of counsel, in form and substance
    reasonably acceptable to Parent, to the effect that such sale, pledge,
    transfer or other disposition is otherwise exempt from registration under
    the Act.

        (b) Parent will give stop transfer instructions to its transfer agent
    with respect to any Parent Common Stock received by Stockholder pursuant to
    the Merger, and there will be placed on the certificates representing such
    Parent Common Stock, or any substitutions therefor, legends stating in
    substance:

       "THE SHARES REPRESENTED BY THIS CERTIFICATE WERE ISSUED PURSUANT TO A
       BUSINESS COMBINATION WHICH IS BEING ACCOUNTED FOR AS A POOLING OF
       INTERESTS, IN A TRANSACTION TO WHICH RULE 145 PROMULGATED UNDER THE
       SECURITIES ACT OF 1933 APPLIES, AND MAY ONLY BE TRANSFERRED IN CONFORMITY
       WITH RULE 145, PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR IN
       ACCORDANCE WITH A WRITTEN OPINION OF COUNSEL, REASONABLY ACCEPTABLE TO
       THE ISSUER, IN FORM AND SUBSTANCE TO THE EFFECT THAT SUCH TRANSFER IS
       EXEMPT FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933. SUCH SHARES
       MAY NOT BE TRANSFERRED UNTIL SUCH TIME AS PARENT SHALL HAVE PUBLISHED
       FINANCIAL RESULTS COVERING AT LEAST 30 DAYS OF COMBINED OPERATIONS WITH
       THE COMPANY."

       and

       "THE SHARES REPRESENTED BY THIS CERTIFICATE MAY NOT BE OFFERED, SOLD,
       PLEDGED, TRANSFERRED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH
       THE REQUIREMENTS OF THE CONDITIONS SPECIFIED IN THE STOCKHOLDER AGREEMENT
       DATED AS OF JUNE   , 1999 BETWEEN THE HOLDER OF THIS CERTIFICATE AND
       PARENT, A COPY OF WHICH AGREEMENT MAY BE INSPECTED BY THE HOLDER OF THIS
       CERTIFICATE AT THE PRINCIPAL OFFICES OF PARENT OR FURNISHED BY PARENT TO
       THE HOLDER OF THIS CERTIFICATE UPON WRITTEN REQUEST AND WITHOUT CHARGE."

The legends set forth above shall be removed (by delivery of a substitute
certificate without such legends), and Parent shall so instruct its transfer
agent, if a registration statement respecting the sale of the shares has been
declared effective under the Act or if Stockholder delivers to Parent (i)
satisfactory written evidence that the shares have been sold in compliance with
Rule 145 (in which case, the substitute certificate will be issued in the name
of the transferee), or (ii) an opinion of counsel, in form and substance
reasonably acceptable to Parent, to the effect that sale of the shares by the
holder thereof is no longer subject to Rule 145.

    3.  COVENANTS RELATED TO POOLING OF INTERESTS.

        (a) During the period beginning on the date 30 days prior to the Closing
    Date (as defined in the Merger Agreement) and ending on the day after Parent
    has published (within the meaning of Section 201.01 of the Commission's
    Codification of Financial Reporting Policies) financial results covering at
    least 30 days of combined operations of Parent and the Company (the
    "Restricted Period"), Stockholder will not sell, exchange, transfer, pledge,
    distribute or otherwise dispose of or

                                      A-49
<PAGE>
    grant any option, establish any "short" or "put"-equivalent position with
    respect to or enter into any similar transaction (through derivatives or
    otherwise) intended to have or having the effect, directly or indirectly, or
    reducing its risk relative to (i) any shares of Company Common Stock owned
    by Stockholder or (ii) any shares of Parent Common Stock received by
    Stockholder in connection with the Merger. The parties acknowledge that
    sales of Parent Common Stock issuable on exercise of stock options solely to
    provide for payment of the exercise price of such stock options
    simultaneously with the exercise of such stock options shall not constitute
    such reduction of relative risk.

    (b) Notwithstanding anything to the contrary contained in Section 3(a),
Stockholder will be permitted, during the Restricted Period, (ii) to sell,
exchange, transfer, pledge, distribute or otherwise dispose of or grant any
option, establish any "short" or "put"-equivalent position with respect to or
enter into any similar transaction (through derivatives or otherwise) intended
to have or having the effect, directly or indirectly, of reducing its risk
relative to any shares of Company Common Stock or Parent Common Stock received
by Stockholder in connection with the Merger (a "Transfer") equal to the lesser
of (A) 10% of the Company Common Stock, or equivalent post-Merger Parent Common
Stock, owned by Stockholder and (B) Stockholder's pro rata portion of 1% of the
total number of outstanding shares of Company Common Stock, or equivalent
post-Merger Parent Common Stock, owned by Stockholder and all other stockholders
of the Company (in each of clause (A) and clause (B) above as measured as of the
date of such Transfer and subject to confirmation of such calculation by
Parent), and (ii) to make bona fide charitable contributions or gifts of such
securities; PROVIDED, HOWEVER, that the transferee(s) of such charitable
contributions or gifts agree(s) in writing to hold such securities for the
period specified in Section 3(a).

    4.  MISCELLANEOUS.

        (a) This Agreement may be executed in one or more counterparts, each of
    which shall be deemed an original, but all of which together shall
    constitute one and the same document.

        (b) This Agreement shall be enforceable by, and shall inure to the
    benefit of and be binding upon, the parties and their respective successors
    and assigns. As used in this Agreement, the term "successors and assigns"
    means, where the context to permits, heirs, executors, administrators,
    trustees and successor trustees, and personal and other representatives.

        (c) This Agreement shall be deemed to be made in and in all respects
    shall be interpreted, construed and governed by and in accordance with
    Delaware law without regard to the conflict of law principles thereof. The
    parties irrevocably and unconditionally consent to submit to the exclusive
    jurisdiction of the courts of the State of Delaware and of the United States
    of America located in Wilmington, Delaware (the "DELAWARE COURTS") for any
    litigation arising out of or relating to this Agreement and the transactions
    contemplated by this Agreement (and agree not to commence any litigation
    relating thereto except in such Delaware Courts), waive any objection to the
    laying of venue of any such litigation in the Delaware Courts and agree not
    to plead or claim in any Delaware Court that such litigation brought therein
    has been brought in an inconvenient forum.

        (d) If any term, provision, covenant, or restriction contained in this
    Agreement is held by a court or a federal or state regulatory agency of
    competent jurisdiction to be invalid, void, or unenforceable, the remainder
    of the terms, provisions, covenants, and restrictions contained in this
    Agreement shall remain in full force and effect, and shall in no way be
    affected, impaired, or invalidated.

        (e) Counsel to and accountants for the parties to the Merger Agreement
    shall be entitled to rely upon this Agreement as needed.

                                      A-50
<PAGE>
        (f) This Agreement shall not be modified or amended, or any right waived
    or any obligations excused, except by a written agreement signed by both
    parties.

        (g) Notwithstanding any other provision contained in this Agreement,
    this Agreement and all obligations under this Agreement shall terminate upon
    the termination of the Merger Agreement in accordance with its terms.

        (h) From and after the Effective Time of the Merger and as long as is
    necessary in order to permit Stockholder to sell Parent Common Stock held by
    Stockholder pursuant to Rule 145 and, to the extent applicable, Rule 144
    under the Act, Parent will file on a timely basis all reports required to be
    filed by it pursuant to the Securities Exchange Act of 1934, as amended, and
    the rules and regulations thereunder, as the same shall be in effect at the
    time, and shall otherwise make available adequate public information
    regarding Parent in such manner as may be required to satisfy the
    requirements of paragraph (c) of Rule 144 under the Act.

    IN WITNESS WHEREOF, this Agreement is executed as of the date first stated
above.

<TABLE>
<S>                             <C>  <C>
                                ABBOTT LABORATORIES,
                                an Illinois corporation

                                By:
                                     -----------------------------------------
                                Name:
                                Title:

                                STOCKHOLDER

                                By:
                                     -----------------------------------------
                                Name:
                                Name of Signatory
                                (if different from name of Stockholder):

                                ---------------------------------------------

                                Title of Signatory
                                (if applicable):

                                Number of Shares Owned:

                                Number of Shares Issuable upon
                                Exercise of Stock Options:
</TABLE>

                                      A-51
<PAGE>
                                 EXHIBIT 6.7(B)
                             STOCKHOLDER AGREEMENT

    This STOCKHOLDER AGREEMENT, dated as of June   , 1999 (this "Agreement"), is
by and between ALZA CORPORATION, a Delaware corporation (the "Company"), and the
undersigned stockholder ("Stockholder") of ABBOTT LABORATORIES, an Illinois
corporation ("Parent"). Capitalized terms not otherwise defined in this
Agreement have the meanings ascribed to them in the Merger Agreement (as defined
below).

                                    RECITALS

    A. The Company and Parent have entered into an Agreement and Plan of Merger,
dated as of June 21, 1999 (the "Merger Agreement"), pursuant to which AC Merger
Sub Inc., a Delaware corporation and a wholly owned subsidiary of Parent
("Merger Sub"), will merge with and into the Company (the "Merger"), with the
Company surviving the Merger and becoming a wholly owned subsidiary of Parent;

    B.  It is a condition to the effectiveness of the Merger that (i) legal
counsel to Parent and the Company shall have delivered their respective opinions
to the effect that the Merger will constitute a reorganization within the
meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended (the
"Code") and Parent, Merger Sub and the Company each will be a party to the
reorganization within the meaning of Section 368(b) of the Code, and (ii) the
independent public accounting firms for Parent and the Company shall have
delivered their respective opinions to the effect that the Merger will qualify
for pooling-of-interests accounting treatment;

    C.  The execution and delivery of this Agreement by Stockholder is a
material inducement to the Company to enter into the Merger Agreement; and

    D. Stockholder has been advised that Stockholder may be deemed to be an
"affiliate" of Parent, as such term is used in the Commission's Accounting
Series Releases 130 and 135, as amended, although nothing contained herein shall
be construed as an admission by Stockholder that Stockholder is in fact an
affiliate of Parent.

    NOW, THEREFORE, intending to be legally bound, the parties agree as follows:

    1.  ACKNOWLEDGMENTS BY STOCKHOLDER.  Stockholder acknowledges and
understands that the representations, warranties and covenants made by
Stockholder set forth in this Agreement will be relied upon by the Company,
Parent and their respective affiliates, counsel and accounting firms, and that
substantial losses and damages may be incurred by such persons if Stockholder's
representations, warranties or covenants are breached. Stockholder has carefully
read this Agreement and the Merger Agreement and has consulted with such legal
counsel and financial advisers as Stockholder has deemed appropriate in
connection with the execution of this Agreement.

    2.  COVENANTS RELATED TO POOLING OF INTERESTS.

        (a) During the period beginning on the date 30 days prior to the Closing
    Date (as defined in the Merger Agreement) and ending on the day after Parent
    has published (within the meaning of Section 201.01 of the Commission's
    Codification of Financial Reporting Policies) financial results covering at
    least 30 days of combined operations of the Company and Parent (the
    "Restricted Period"), Stockholder will not sell, exchange, transfer, pledge,
    distribute or otherwise dispose of or grant any option, establish any
    "short" or "put"-equivalent position with respect to or enter into any
    similar transaction (through derivatives or otherwise) intended to have or
    having the effect, directly or indirectly, of reducing its risk relative to
    any shares of Parent Common Stock owned by Stockholder. The parties
    acknowledge that sales of Parent Common Stock issuable on exercise of stock
    options solely to provide for payment of the exercise price of such stock
    options

                                      A-52
<PAGE>
    simultaneously with the exercise of such stock options shall not constitute
    such reduction of relative risk.

        (b) Notwithstanding anything to the contrary contained in Section 2(a),
    Stockholder will be permitted, during the Restricted Period, (i) to sell,
    exchange, transfer, pledge, distribute or otherwise dispose of or grant any
    option, establish any "short" or "put'-equivalent position with respect to
    or enter into any similar transaction (through derivatives or otherwise)
    intended to have or having the effect, directly or indirectly, of reducing
    its risk relative to any shares of Parent Common Stock owned by Stockholder
    (a "Transfer") equal to the lesser of (A) 10% of the Parent Common Stock
    owned by Stockholder and (B) Stockholder's pro rata portion of 1% of the
    total number of outstanding shares of Parent Common Stock owned by
    Stockholder and all other stockholders of Parent (in each of clause (A) and
    clause (B) above as measured as of the date of such Transfer and subject to
    confirmation of such calculation by Parent), and (ii) to make bona fide
    charitable contributions or gifts of such securities; provided, however,
    that the transferee(s) of such charitable contributions or gifts agree(s) in
    writing to hold such securities for the period specified in Section 2(a).

    3.  MISCELLANEOUS.

        (a) This Agreement may be executed in one or more counterparts, each of
    which shall be deemed an original, but all of which together shall
    constitute one and the same document.

        (b) This Agreement shall be enforceable by, and shall inure to the
    benefit of and be binding upon, the parties and their respective successors
    and assigns. As used in this Agreement, the term "successors and assigns"
    means, where the context so permits, heirs, executors, administrators,
    trustees and successor trustees, and personal and other representatives.

        (c) This Agreement shall be deemed to be made in and in all respects
    shall be interpreted, construed and governed by and in accordance with
    Delaware law without regard to the conflict of law principles thereof. The
    parties irrevocably and unconditionally consent to submit to the exclusive
    jurisdiction of the courts of the State of Delaware and of the United States
    of America located in Wilmington, Delaware (the "DELAWARE COURTS") for any
    litigation arising out of or relating to this Agreement and the transactions
    contemplated by this Agreement (and agree not to commence any litigation
    relating thereto except in such Delaware Courts), waive any objection to the
    laying of venue of any such litigation in the Delaware Courts and agree not
    to plead or claim in any Delaware Court that such litigation brought therein
    has been brought in an inconvenient forum.

        (d) If any term, provision, covenant, or restriction contained in this
    Agreement is held by a court or a federal or state regulatory agency of
    competent jurisdiction to be invalid, void, or unenforceable, the remainder
    of the terms, provisions, covenants, and restrictions contained in this
    Agreement shall remain in full force and effect, and shall in no way be
    affected, impaired, or invalidated.

        (e) Counsel to and accountants for the parties to the Merger Agreement
    shall be entitled to rely upon this Agreement as needed.

        (f) This Agreement shall not be modified or amended, or any right waived
    or any obligation excused, except by a written agreement signed by both
    parties.

        (g) Notwithstanding any other provision contained in this Agreement,
    this Agreement and all obligations under this Agreement shall terminate upon
    the termination of the Merger Agreement in accordance with its terms.

                                      A-53
<PAGE>
    IN WITNESS WHEREOF, this Agreement is executed as of the date first stated
above.

<TABLE>
<S>                             <C>  <C>
                                ALZA CORPORATION,
                                a Delaware corporation

                                By:
                                     -----------------------------------------
                                Name:
                                Title:

                                STOCKHOLDER

                                By:

                                Name:
                                Name of Signatory
                                (if different from name of Stockholder):

                                Title of Signatory
                                (if applicable):

                                Number of Shares Owned:

                                Number of Shares Issuable upon
                                Exercise of Stock Options:
</TABLE>

                                      A-54
<PAGE>
                                                                         ANNEX B

                                     [LOGO]
CHASE SECURITIES INC.
270 Park Avenue
New York, NY 10017-2070

                                 June 21, 1999

Board of Directors
ALZA Corporation
950 Page Mill Road
Palo Alto, CA 94304
Members of the Board:

    You have informed us that ALZA Corporation (the "Company"), Abbott
Laboratories ("Parent") and AC MERGER SUB, a wholly owned subsidiary of Parent
("Merger Sub"), propose to enter into an Agreement and Plan of Merger dated as
of June 21, 1999 (the "Merger Agreement") which provides, among other things,
that Merger Sub will be merged with and into the Company (the "Merger") in a
transaction in which each outstanding share of common stock of the Company, par
value $.01 per share (the "Company Common Stock"), other than shares of the
Company Common Stock that are owned by the Company, Parent, Merger Sub, or their
respective subsidiaries, all of which will be canceled, will be converted into
the right to receive 1.20 shares (the "Exchange Ratio") of common stock of
Parent, no par value (the "Parent Common Stock"). As a result of the Merger, the
Company will become a wholly-owned subsidiary of Parent.

    You have requested that we render our opinion as to the fairness, from a
financial point of view, to the holders of the Company Common Stock of the
Exchange Ratio.

    In arriving at the opinion set forth below, we have, among other things:

    (a) reviewed the Merger Agreement;

    (b) reviewed certain publicly available business and financial information
       that we deemed relevant relating to the Company and Parent and the
       industries in which they operate;

    (c) reviewed certain internal non-public financial and operating data and
       forecasts provided to us by the management of the Company relating to the
       business of the Company;

    (d) discussed, with members of the senior managements of the Company and
       Parent, the Company's and Parent's operations, historical financial
       statements and future prospects, before and after giving effect to the
       Merger (and, in the case of the future prospects of Parent, been informed
       by the Parent to rely on public analysts' estimates as the most
       reasonable estimates for the purposes of this opinion);

    (e) compared the financial and operating performance of the Company and
       Parent with publicly available information concerning certain other
       companies we deemed comparable and reviewed the relevant historical stock
       prices of the Company Common Stock and the Parent Common Stock and
       certain publicly traded securities of such other companies;

    (f) reviewed the financial terms of certain recent business combinations and
       acquisition transactions we deemed reasonably comparable to the Merger
       and otherwise relevant to our inquiry; and

                                      B-1
<PAGE>
    (g) made such other analyses and examinations as we have deemed necessary or
       appropriate.

    Other than as set forth in clause (d) above, in connection with the
preparation of this opinion, we have neither received nor reviewed any
non-public information prepared by or relating to Parent.

    We have assumed and relied upon, without assuming any responsibility for
verification, the accuracy and completeness of all of the financial and other
information provided to, discussed with or reviewed by or for us, or publicly
available, for purposes of this opinion and have further relied upon the
assurance of the managements of the Company and Parent that they are not aware
of any facts that would make such information inaccurate or misleading in any
material respect. We have neither made nor obtained any independent evaluations
or appraisals of the assets or liabilities of the Company or Parent, nor have we
conducted a physical inspection of the properties and facilities of the Company
or Parent. We have assumed that the financial forecasts provided to us by the
Company and the financial forecast guidance provided to us by Parent have been
reasonably determined on bases reflecting the best currently available estimates
and judgments of the managements of the Company and Parent as to the future
financial performance of the Company or Parent, as the case may be. We express
no view as to such forecast or projection information or the assumptions on
which they were based.

    For purposes of rendering our opinion, we have assumed that, in all respects
material to our analysis, the representations and warranties of each party
contained in the Merger Agreement are true and correct, that each party will
perform all of the covenants and agreements required to be performed by it under
the Merger Agreement and that all conditions to the consummation of the Merger
will be satisfied without waiver thereof. We have further assumed that all
material governmental, regulatory or other consents and approvals will be
obtained and that in the course of obtaining any necessary governmental,
regulatory or other consents and approvals, or any amendments, modifications or
waivers to any documents to which any of the Company or Parent are a party, as
contemplated by the Merger Agreement, no restrictions will be imposed or
amendments, modifications or waivers made that would have any material adverse
effect on the contemplated benefits to the Company of the Merger. We have
further assumed that the Merger will be accounted for as a pooling of interests
under generally accepted accounting principles and that it will qualify as a
tax-free reorganization for U.S. Federal income tax purposes.

    In connection with the preparation of this opinion, we have not been
authorized by the Company or the Board of Directors to solicit, nor have we
solicited, third-party indications of interest for the acquisition of all or any
part of the Company.

    Our opinion herein is necessarily based on market, economic and other
conditions as they exist and can be evaluated on the date of this letter. Our
opinion is limited to the fairness, from a financial point of view, to the
holders of the Company Common Stock of the Exchange Ratio and we express no
opinion as to the merits of the underlying decision by the Company to engage in
the Merger. This opinion does not constitute a recommendation to any stockholder
of the Company as to how such stockholder should vote with respect to the
Merger. In addition, we express no opinion as to the prices at which the Company
Common Stock or the Parent Common Stock will trade following the announcement or
the consummation, as the case may be, of the Merger.

    Chase Securities Inc., as part of its financial advisory business, is
continually engaged in the valuation of businesses and their securities in
connection with mergers and acquisitions and valuations for estate, corporate
and other purposes. We have acted as financial advisor to the Company in
connection with the Merger and will receive a fee for our services, payment of a
significant portion of which is contingent upon the consummation of the Merger.
In addition, the Company has agreed to indemnify us for certain liabilities
arising out of our engagement. As we have previously advised you, The Chase
Manhattan Corporation and its affiliates, including Chase Securities Inc., in
the ordinary course of business, have, from time to time, provided commercial
and investment banking services to Parent, for which we received usual and
customary compensation and in the future may continue to

                                      B-2
<PAGE>
provide such commercial and investment banking services. In the ordinary course
of business, we or our affiliates may trade in the debt and equity securities of
the Company and Parent for our own accounts and for the accounts of our
customers and, accordingly, may at any time hold a long or short position in
such securities.

    Based upon and subject to the foregoing, we are of the opinion that, as of
the date hereof, the Exchange Ratio is fair, from a financial point of view, to
the holders of the Company Common Stock.

    This opinion is for the use and benefit of the Board of Directors of the
Company in its evaluation of the Merger and shall not be used for any other
purpose without the prior written consent of Chase Securities Inc. This opinion
shall not be reproduced, disseminated, quoted, summarized or referred to at any
time, in any manner or for any purpose, nor shall any public references to Chase
Securities Inc. be made by the Company, without the prior written consent of
Chase Securities Inc.

                                          Very truly yours,

                                                        [LOGO]

                                          CHASE SECURITIES INC.

                                      B-3
<PAGE>
                                                                         ANNEX C

                                 [LOGO]

Board of Directors
ALZA Corporation
950 Page Mill Road
Palo Alto, CA 94303

                               June 21, 1999

Members of the Board of Directors:

    ALZA Corporation (the "Company"), Abbott Laboratories ("Abbott") and a
wholly owned subsidiary of Abbott (the "Acquisition Sub") propose to enter into
an Agreement and Plan of Merger (the "Agreement") pursuant to which the
Acquisition Sub will be merged with and into the Company (the "Merger") in a
transaction in which each outstanding share of the Company's common stock (the
"Company Shares") will be converted into the right to receive 1.20 shares (the
"Exchange Ratio") of the common stock of Abbott (the "Abbott Shares").

    You have asked us whether, in our opinion, the Exchange Ratio is fair from a
financial point of view to the holders of the Company Shares.

    In arriving at the opinion set forth below, we have, among other things:

    (1) Reviewed certain publicly available business and financial information
       relating to the Company and Abbott that we deemed to be relevant;

    (2) Reviewed certain information, including financial forecasts, relating to
       the business, earnings, cash flow, assets, liabilities and prospects of
       the Company, as well as the amount and timing of the cost savings and
       related expenses and synergies expected to result from the Merger (the
       "Expected Synergies"), furnished to us by the Company;

    (3) Conducted discussions with members of senior management and
       representatives of the Company and Abbott concerning the operations,
       historical financial statements and future prospects of the Company and
       Abbott, before and after giving effect to the merger (and, in the case of
       the future prospects of Abbott, Merrill Lynch was informed by Abbott to
       rely on public analysts' estimates as the most reasonable estimates for
       the purposes of this opinion);

    (4) Reviewed the market prices and valuation multiples for the Company
       Shares and the Abbott Shares and compared them with those of certain
       publicly traded companies that we deemed to be relevant;

    (5) Compared the proposed financial terms of the Merger with the financial
       terms of certain other transactions that we deemed to be relevant;

    (6) Participated in certain discussions and negotiations among
       representatives of the Company and Abbott and their financial and legal
       advisors;

                                      C-1
<PAGE>
    (7) Reviewed the potential pro forma impact of the Merger;

    (8) Reviewed the Agreement between the Company and Abbott; and

    (9) Reviewed such other financial studies and analyses and took into account
       such other matters as we deemed necessary, including our assessment of
       general economic, market and monetary conditions.

    In preparing our opinion, we have assumed and relied on the accuracy and
completeness of all information supplied or otherwise made available to us,
discussed with or reviewed by or for us, or publicly available, and we have not
assumed any responsibility for independently verifying such information or
undertaken an independent evaluation or appraisal of any of the assets or
liabilities of the Company or Abbott or been furnished with any such evaluation
or appraisal. In addition, we have not assumed any obligation to conduct any
physical inspection of the properties or facilities of the Company or Abbott.
With respect to the financial forecast information and the Expected Synergies
furnished to or discussed with us by the Company and the financial forecast
guidance furnished to us by Abbott, we have assumed that they have been
reasonably prepared and reflect the best currently available estimates and
judgment of the Company's or Abbott's management as to the expected future
financial performance of the Company or Abbott, as the case may be, and the
Expected Synergies. We have further assumed that the Merger will be accounted
for as a pooling of interests under generally accepted accounting principles and
that it will qualify as a tax-free reorganization for U.S. federal income tax
purposes.

    Our opinion is necessarily based upon market, economic and other conditions
as they exist and can be evaluated on, and on the information made available to
us as of, the date hereof. We have assumed that in the course of obtaining the
necessary regulatory or other consents or approvals (contractual or otherwise)
for the Merger, no restrictions, including any divestiture requirements or
amendments or modifications, will be imposed that will have a material adverse
effect on the contemplated benefits of the Merger.

    In connection with the preparation of this opinion, we have not been
authorized by the Company or the Board of Directors to solicit, nor have we
solicited, third-party indications or interest for the acquisition of all or any
part of the Company.

    We are acting as financial advisor to the Company in connection with the
Merger and will receive a fee from the Company for our services, a significant
portion of which is contingent upon the consummation of the Merger. In addition,
the Company has agreed to indemnify us for certain liabilities arising out of
our engagement. We have, in the past, provided financial advisory and financing
services to the Company and Abbott and may continue to do so and have received,
and may receive, fees for the rendering of such services. In addition, in the
ordinary course of our business, we may actively trade the Company Shares and
other securities of the Company, as well as the Abbott Shares and other
securities of Abbott, for our own account and for the accounts of customers and,
accordingly, may at any time hold a long or short position in such securities.

    This opinion is for the use and benefit of the Board of Directors of the
Company. Our opinion does not address the merits of the underlying decision by
the Company to engage in the Merger and does not constitute a recommendation to
any shareholder as to how such shareholder should vote on the proposed Merger or
any matter related thereto.

    We are not expressing any opinion herein as to the prices at which the
Company Shares or the Abbott Shares will trade following the announcement or
consummation of the Merger.

                                      C-2
<PAGE>
    On the basis of and subject to the foregoing, we are of the opinion that, as
of the date hereof, the Exchange Ratio is fair from a financial point of view to
the holders of the Company Shares.

                                          Very truly yours,

                               Merrill Lynch, Pierce Fenner & Smith Incorporated

                                      C-3
<PAGE>
2350-PS-99
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 20. INDEMNIFICATION OF OFFICERS AND DIRECTORS

    Restated Article R-VI of Abbott's Restated Articles of Incorporation
provides that Abbott shall, in the case of persons who are or were directors or
officers of Abbott, and may, as to other persons, indemnify to the fullest
extent permitted by law any person who was or is a party, or is threatened to be
made a party, to any threatened, pending or completed action, suit or
proceeding, whether civil, criminal, administrative or investigative, by reason
of the fact that he is or was a director, officer, employee or agent of Abbott,
or is or was serving at the request of Abbott as a director, officer, employee
or agent of another corporation, partnership, joint venture, trust or other
enterprise. The provisions of Article R-VI are applicable to all expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement
actually and reasonably incurred in connection with such action, suit or
proceeding. Expenses incurred in defending a civil or criminal action, suit or
proceeding may be paid by Abbott in advance of the final disposition of such
action, suit or proceeding, as authorized by Abbott's Board of Directors in the
specific case, upon receipt of an undertaking by or on behalf of the director,
officer, employee or agent to repay such amount, unless it shall ultimately be
determined that he or she is entitled to indemnification.

    Section 8.75 of the Illinois Business Corporation Act provides that a
corporation may indemnify any person (or his or her personal representatives)
who, by reason of the fact that such person is or was a director or officer of
such corporation, is made (or threatened to be made) a party to any pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative, other than one brought on behalf of the corporation, against
reasonable expenses (including attorneys' fees), judgments, fines and settlement
payments, if such person acted in good faith and in a manner he or she
reasonably believed to be not opposed to the best interests of such corporation
and, in criminal actions, in addition, had no reasonable cause to believe his or
her conduct was unlawful. In the case of actions on behalf of the corporation,
indemnification may extend only to reasonable expenses (including attorneys'
fees) and only if such person acted in good faith and in a manner he or she
reasonably believed to be not opposed to the best interests of the corporation,
provided that no such indemnification is permitted in respect of any claim,
issue or matter as to which such person is adjudged to be liable for negligence
or misconduct in the performance of his or her duty to the corporation except to
the extent that the adjudicating court otherwise provides. To the extent that
such person has been successful in defending any action, suit or proceeding
(even one on behalf of the corporation) or in defense of any claim, issue or
matter therein, such person is entitled to indemnification for reasonable
expenses (including attorney's fees) incurred by such person in connection
therewith.

    The indemnification provided for by the Illinois Business Corporation Act is
not exclusive of any other rights of indemnification, and a corporation may
maintain insurance against liabilities for which indemnification is not
expressly provided by the Illinois Business Corporation Act. Abbott's directors
and officers are insured under a directors and officers liability insurance
policy maintained by Abbott.

ITEM 21.  EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

    (a) Exhibits

        See Index to Exhibits included herewith which is incorporated by
    reference herein.

    (b) Financial Statement Schedules:

        Not Applicable

                                      II-1
<PAGE>
ITEM 22.  UNDERTAKINGS.

    The undersigned Registrant hereby undertakes:

        (1) To file, during any period in which offers or sales are being made,
    a post-effective amendment to this Registration Statement:

            (i) To include any prospectus required by Section 10(a)(3) of the
       Securities Act of 1933;

            (ii) To reflect in the prospectus any facts or events arising after
       the effective date of the Registration Statement (or the most recent
       post-effective amendment thereof) which, individually or in the
       aggregate, represent a fundamental change in the information set forth in
       the Registration Statement. Notwithstanding the foregoing, any increase
       or decrease in volume of securities offered (if the total dollar value of
       securities offered would not exceed that which was registered) and any
       deviation from the low or high end of the estimated maximum offering
       range may be reflected in the form of prospectus filed with the
       Commission pursuant to Rule 424(b) if, in the aggregate, the changes in
       volume and price represent no more than 20 percent change in the maximum
       aggregate offering price set forth in the "Calculation of Registration
       Fee" table in the effective registration statement;

           (iii) To include any material information with respect to the plan of
       distribution not previously disclosed in the Registration Statement or
       any material change to such information in the Registration Statement;

           provided, however, that paragraphs (1)(i) and (1)(ii) do
           not apply if the information required to be included in a
           post-effective amendment by those paragraphs is contained
           in periodic reports filed by the Registrant pursuant to
           Section 13 or Section 15(d) of the Securities Exchange Act
           of 1934 that are incorporated by reference in the
           Registration Statement;

        (2) That, for the purpose of determining any liability under the
    Securities Act of 1933, each such post-effective amendment shall be deemed
    to be a new registration statement relating to the securities offered
    therein, and the offering of such securities at that time shall be deemed to
    be the initial bona fide offering thereof;

        (3) To remove from registration by means of a post-effective amendment
    any of the securities being registered which remain unsold at the
    termination of the offering;

        (4) That, for purposes of determining any liability under the Securities
    Act of 1933, each filing of the Registrant's annual report pursuant to
    Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that
    is incorporated by reference in the Registration Statement shall be deemed
    to be a new registration statement relating to the securities offered
    therein, and the offering of such securities at that time shall be deemed to
    be the initial bona fide offering thereof;

        (5) That, prior to any public reoffering of the securities registered
    hereunder through use of a prospectus which is a part of this Registration
    Statement, by any person or party who is deemed to be an underwriter within
    the meaning of Rule 145(c), the issuer undertakes that such reoffering
    prospectus will contain the information called for by the applicable
    registration form with respect to reofferings by persons who may be deemed
    underwriters, in addition to the information called for by the other Items
    of the applicable form;

        (6) That every prospectus (i) that is filed pursuant to paragraph (5)
    immediately preceding, or (ii) that purports to meet the requirements of
    Section 10(a)(3) of the Securities Act of 1933 and is used in connection
    with an offering of securities subject to Rule 415, will be filed as a part
    of an amendment to the Registration Statement and will not be used until
    such amendment is effective, and that, for purposes of determining any
    liability under the Securities Act of 1933, each such

                                      II-2
<PAGE>
    post-effective amendment shall be deemed to be a new registration statement
    relating to the securities offered therein, and the offering of such
    securities at that time shall be deemed to be the initial bona fide offering
    thereof;

        (7) To respond to requests for information that is incorporated by
    reference into the prospectus pursuant to Item 4, 10(b), 11, or 13 of this
    form, within one business day of receipt of such request, and to send the
    incorporated documents by first class mail or other equally prompt means.
    This includes information contained in documents filed subsequent to the
    effective date of the registration statement through the date of responding
    to the request; and

        (8) To supply by means of a post-effective amendment all information
    concerning a transaction, and the company being acquired involved therein,
    that was not the subject of and included in the registration statement when
    it became effective.

    Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the provisions described under Item 20 above or
otherwise, the Registrant has been advised that in the opinion of the Securities
and Exchange Commission such indemnification is against public policy as
expressed in the Act and is, therefore, unenforceable. In the event that a claim
for indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.

                                      II-3
<PAGE>
                                   SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, Abbott
Laboratories has duly caused this Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in Abbott Park, Illinois,
August 16, 1999.
<TABLE>
<S>                                           <C>        <C>                                       <C>
                                              ABBOTT LABORATORIES

                                                                By:

<CAPTION>
                                                                                     /s/ MILES D. WHITE

                                                                         -----------------------------------------

                                                                                       Miles D. White

                                                                            CHAIRMAN AND CHIEF EXECUTIVE OFFICER

</TABLE>

    Each person whose signature appears below on this Registration Statement
hereby constitutes and appoints Jose M. de Lasa and Gary P. Coughlan and each of
them, with full power to act without the other, as his or her true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities (unless revoked in writing), to sign any and all amendments to the
Registrant's Form S-4 Registration Statement, and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting to such attorney-in-fact and
agents, and each of them, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he or she might and could do in person,
hereby ratifying and confirming all that such attorney-in-fact and agents or any
of them, or their or his substitute or substitutes, may lawfully do or cause to
be done by virtue hereof.

    Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated on August 16, 1999.

<TABLE>
<S>                                           <C>
             /s/ MILES D. WHITE                           /s/ GARY P. COUGHLAN
- -------------------------------------------   -------------------------------------------
               Miles D. White                               Gary P. Coughlan
  CHAIRMAN AND CHIEF EXECUTIVE OFFICER AND         SENIOR VICE PRESIDENT, FINANCE AND
                  DIRECTOR                              CHIEF FINANCIAL OFFICER
       (PRINCIPAL EXECUTIVE OFFICER)                 (PRINCIPAL FINANCIAL OFFICER)

        /s/ ROBERT L. PARKINSON, JR.                       /s/ GARY L. FLYNN
- -------------------------------------------   -------------------------------------------
          Robert L. Parkinson, Jr.                           Gary L. Flynn
   PRESIDENT, CHIEF OPERATING OFFICER AND            VICE PRESIDENT AND CONTROLLER
                  DIRECTOR                           (PRINCIPAL ACCOUNTING OFFICER)

           /s/ H. LAURANCE FULLER                          /s/ DAVID A. JONES
- -------------------------------------------   -------------------------------------------
             H. Laurance Fuller                              David A. Jones
                  DIRECTOR                                      DIRECTOR

     /s/ JEFFREY M. LEIDEN, M.D., PH.D.                   /s/ DAVID A. L. OWEN
- -------------------------------------------   -------------------------------------------
       Jeffrey M. Leiden, M.D., Ph.D.                       David A. L. Owen
                  DIRECTOR                                      DIRECTOR
</TABLE>
<PAGE>
<TABLE>
<S>                                           <C>
           /s/ BOONE POWELL, JR.                         /s/ ADDISON BARRY RAND
- -------------------------------------------   -------------------------------------------
             Boone Powell, Jr.                             Addison Barry Rand
                  DIRECTOR                                      DIRECTOR

         /s/ W. ANN REYNOLDS, PH.D.                        /s/ ROY S. ROBERTS
- -------------------------------------------   -------------------------------------------
           W. Ann Reynolds, Ph.D.                            Roy S. Roberts
                  DIRECTOR                                      DIRECTOR

          /s/ WILLIAM D. SMITHBURG                         /s/ JOHN R. WALTER
- -------------------------------------------   -------------------------------------------
            William D. Smithburg                             John R. Walter
                  DIRECTOR                                      DIRECTOR

            /s/ WILLIAM L. WEISS
- -------------------------------------------
              William L. Weiss
                  DIRECTOR
</TABLE>
<PAGE>
                                 EXHIBIT INDEX

<TABLE>
<CAPTION>
EXHIBIT
NUMBER                                               DOCUMENT DESCRIPTION
- ---------  --------------------------------------------------------------------------------------------------------
<C>        <S>
     2.1   Agreement and Plan of Merger dated as of June 21, 1999 among ALZA Corporation, Abbott Laboratories and
           AC Merger Sub Inc. (Included as Annex A to the proxy statement/ prospectus included herein.)

     3.1   Restated Articles of Incorporation of Abbott Laboratories. (Filed as Exhibit 3.1 to Abbott's Quarterly
           Report on Form 10-Q for the quarter ended March 31, 1998 (File No. 1-2189), and incorporated by
           reference herein.)

     3.2   Corporate By-laws of Abbott Laboratories. (Filed as Exhibit 3.1 to Abbott's Quarterly Report on Form
           10-Q for the quarter ended March 31, 1999 (File No. 1-2189), and incorporated by reference herein.)

     3.3   Restated Certificate of Incorporation of ALZA Corporation. (Filed as Exhibit 3.1 to ALZA's Annual Report
           on Form 10-K for the year ended December 31, 1993 (File No. 1-6247), and incorporated by reference
           herein.)

     3.4   Composite Bylaws of ALZA Corporation. (Filed as Exhibit 3.1 to ALZA's Quarterly Report on Form 10-Q for
           the quarter ended March 31, 1999 (File No. 1-6247), and incorporated by reference herein.)

     4.1   Indenture dated as of October 1, 1993, between Abbott Laboratories and Harris Trust and Savings Bank.
           (Filed as Exhibit 4.1 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30,
           1993, on Form 10-Q (File No. 1-2189), and incorporated by reference herein.)

     4.2   Form of 5.6% Note issued pursuant to the Indenture. (Filed as Exhibit 4.2 to Abbott's Quarterly Report
           on Form 10-Q for the quarter ended September 30, 1993 (File No. 1-2189), and incorporated by reference
           herein.)

     4.3   Form of Medium-Term Note, Series A (Fixed Rate) to be issued pursuant to the Indenture. (Filed as
           Exhibit 4.3 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1993 (File No.
           1-2189), and incorporated by reference herein.)

     4.4   Form of Medium-Term Note, Series A (Floating Rate) to be issued pursuant to the Indenture. (Filed as
           Exhibit 4.4 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1993 (File No.
           1-2189), and incorporated by reference herein.)

     4.5   Resolution of Abbott's Board of Directors. (Filed as Exhibit 4.5 to Abbott's Quarterly Report on Form
           10-Q for the quarter ended September 30, 1993 (File No. 1-2189), and incorporated by reference herein.)

     4.6   Actions of the Authorized Officers with respect to Abbott's $200,000,000 5.6% Notes. (Filed as Exhibit
           4.6 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1993 (File No.
           1-2189), and incorporated by reference herein.)

     4.7   Actions of the Authorized Officers with respect to Abbott's Medium-Term Notes, Series A. (Filed as
           Exhibit 4.7 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1993 (File No.
           1-2189), and incorporated by reference herein.)

     4.8   Officers' Certificate and Company Order with respect to Abbott's $200,000,000 5.6% Notes. (Filed as
           Exhibit 4.8 to Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1993 (File No.
           1-2189), and incorporated by reference herein.)

     4.9   Form of 6.8% Note issued pursuant to Indenture. (Filed as Exhibit 4.9 to Abbott's Annual Report on Form
           10-K for the year ended December 31, 1995 (File No. 1-2189), and incorporated by reference herein.)
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                                               DOCUMENT DESCRIPTION
- ---------  --------------------------------------------------------------------------------------------------------
<C>        <S>
     4.10  Actions of Authorized Officers with respect to Abbott's $150,000,000 6.8% Notes. (Filed as Exhibit 4.10
           to Abbott's Annual Report on Form 10-K for the year ended December 31, 1995 (File No. 1-2189), and
           incorporated by reference herein.)

     4.11  Officers' Certificate and Company Order with respect to Abbott's $150,000,000 6.8% Notes. (Filed as
           Exhibit 4.11 to Abbott's Annual Report on Form 10-K for the year ended December 31, 1995 (File No.
           1-2189), and incorporated by reference herein.)

     4.12  Resolution of Abbott's Board of Directors relating to the 6.4% Notes. (Filed as Exhibit 4.12 to Abbott's
           Annual Report on Form 10-K for the year ended December 31, 1995 (File No. 1-2189), and incorporated by
           reference herein.)

     4.13  Form of $50,000,000 6.4% Note issued pursuant to Indenture. (Filed as Exhibit 4.13 to Abbott's Annual
           Report on Form 10-K for the year ended December 31, 1996 (File No. 1-2189), and incorporated by
           reference herein.)

     4.14  Form of $200,000,000 6.4% Note issued pursuant to Indenture. (Filed as Exhibit 4.14 to Abbott's Annual
           Report on Form 10-K for the year ended December 31, 1996 (File No. 1-2189), and incorporated by
           reference herein.)

     4.15  Actions of Authorized Officers with respect to Abbott's 6.4% Notes. (Filed as Exhibit 4.15 to Abbott's
           Annual Report on Form 10-K for the year ended December 31, 1996 (File No. 1-2189), and incorporated by
           reference herein.)

     4.16  Officers' Certificate and Company Order with respect to Abbott's 6.4% Notes. (Filed as Exhibit 4.16 to
           Abbott's Annual Report on Form 10-K for the year ended December 31, 1996 (File No. 1-2189), and
           incorporated by reference herein.)

     4.17  Form of $200,000,000 6.0% Note issued pursuant to Indenture. (Filed as Exhibit 4.2 to Abbott's Quarterly
           Report on Form 10-Q for the quarter ended June 30, 1998 (File No. 1-2189), and incorporated by reference
           herein.)

     4.18  Actions of Authorized Officers with respect to Abbott's 6.0% Note. (Filed as Exhibit 4.3 to Abbott's
           Quarterly Report on Form 10-Q for the quarter ended June 30, 1998 (File No. 1-2189), and incorporated by
           reference herein.)

     4.19  Officers' Certificate and Company Order with respect to Abbott's 6.0% Note. (Filed as Exhibit 4.4 to
           Abbott's Quarterly Report on Form 10-Q for the quarter ended June 30, 1998 (File No. 1-2189), and
           incorporated by reference herein.)

     4.20  Form of $200,000,000 5.40% Note issued pursuant to Indenture. (Filed as Exhibit 4.2 to Abbott's
           Quarterly Report on Form 10-Q for the quarter ended September 30, 1998 (File No. 1-2189), and
           incorporated by reference herein.)

     4.21  Actions of Authorized Officers with respect to Abbott's 5.40% Note. (Filed as Exhibit 4.3 to Abbott's
           Quarterly Report on Form 10-Q for the quarter ended September 30, 1998 (File No. 1-2189), and
           incorporated by reference herein.)

     4.22  Officers' Certificate and Company Order with respect to Abbott's 5.40% Note. (Filed as Exhibit 4.4 to
           Abbott's Quarterly Report on Form 10-Q for the quarter ended September 30, 1998 (File No. 1-2189), and
           incorporated by reference herein.)

     4.23  Indenture dated April 23, 1996 between ALZA Corporation and the Chase Manhattan Bank, N.A., as Trustee,
           relating to ALZA's 5% Convertible Subordinated Debentures (with attached specimen of 5% Convertible
           Subordinated Debenture). (Filed as Exhibit 4.2 to ALZA's Registration Statement on Form S-3 (File No.
           333-2343), and incorporated by reference herein.)
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                                               DOCUMENT DESCRIPTION
- ---------  --------------------------------------------------------------------------------------------------------
<C>        <S>
     4.24  Indenture dated July 7, 1994 between ALZA Corporation and the Chase Manhattan Bank, N.A., as Trustee,
           relating to ALZA's 5 1/4% Liquid Yield Option-Registered Trademark- Notes (with attached specimen of
           LYONs-TM- Certificate). (Filed as Exhibit 4.2 to ALZA's Quarterly Report on Form 10-Q for the quarter
           ended June 30, 1994 (File No. 1-6247), and incorporated by reference herein.)

     4.25  Form of Warrant Agreement between ALZA Corporation and the Chase Manhattan Bank (with attached Warrant
           Certificate). (Filed as Exhibit 1 to ALZA's Registration Statement on Form 8-A (File No. 0-11234), and
           incorporated by reference herein.)

           Other debt instruments are omitted in accordance with Item 601(b)(4)(iii)(A) of
           Regulation S-K. Copies of such agreements will be furnished to the Securities and Exchange Commission
           upon request.

     5.1   Opinion of Mayer, Brown & Platt.

     8.1   Tax opinion of Heller Ehrman White & McAuliffe.

    10.1   Supplemental Plan Abbott Laboratories Extended Disability Plan. (Filed as pages 50-51 to Abbott's Annual
           Report on Form 10-K for the year ended December 31, 1992 (File No. 1-2189), and incorporated by
           reference herein.)

    10.2   The Abbott Laboratories 1986 Incentive Stock Program. (Filed as Exhibit 10.2 to Abbott's Annual Report
           on Form 10-K for the year ended December 31, 1997 (File No. 1-2189), and incorporated by reference
           herein.)

    10.3   The Abbott Laboratories 1991 Incentive Stock Program. (Filed as Exhibit 10.3 to Abbott's Annual Report
           on Form 10-K for the year ended December 31, 1997 (File No. 1-2189), and incorporated by reference
           herein.)

    10.4   Abbott Laboratories 401(k) Supplemental Plan. (Filed as Exhibit 10.7 to Abbott's Annual Report on Form
           10-K for the year ended December 31, 1993 (File No. 1-2189), and incorporated by reference herein.)

    10.5   Abbott Laboratories Supplemental Pension Plan. (Filed as Exhibit 10.1 to Abbott's Quarterly Report on
           Form 10-Q for the quarter ended June 30, 1998 (File No. 1-2189), and incorporated by reference herein.)

    10.6   The 1986 Abbott Laboratories Management Incentive Plan. (Filed as Exhibit 10.7 to Abbott's Quarterly
           Report on Form 10-Q for the quarter ended June 30, 1997 (File No. 1-2189), and incorporated by reference
           herein.)

    10.7   Abbott Laboratories Non-Employee Directors' Fee Plan. (Filed as Exhibit 10.9 to Abbott's Annual Report
           on Form 10-K for the year ended December 31, 1998 (File No. 1-2189), and incorporated by reference
           herein.)

    10.8   The Abbott Laboratories 1996 Incentive Stock Program. (Filed as Exhibit 10.9 to Abbott's Annual Report
           on Form 10-K for the year ended December 31, 1997 (File No. 1-2189), and incorporated by reference
           herein.)

    10.9   1998 Abbott Performance Incentive Plan. (Filed as Exhibit 10.1 to Abbott's Quarterly Report on Form 10-Q
           for the quarter ended March 31, 1998 (File No. 1-2189), and incorporated by reference herein.)

    10.10  Amended and Restated Executive Deferral Plan II. (Filed as Exhibit 10.5 to ALZA's Annual Report on Form
           10-K for the year ended December 31, 1998 (File No. 1-6247), and incorporated by reference herein.)

    10.11  Executive Deferral Plan II for Chief Executive Officer. (Filed as Exhibit 10.1 to ALZA's Quarterly
           Report on Form 10-Q for the quarter ended September 30, 1993 (File No. 1-6247), and incorporated by
           reference herein.)
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                                               DOCUMENT DESCRIPTION
- ---------  --------------------------------------------------------------------------------------------------------
<C>        <S>
    10.12  Executive Deferral Plan Amendments. (Filed as Exhibit 10.4 to ALZA's Annual Report on Form 10-K for the
           year ended December 31, 1992 (File No. 1-6247), and incorporated by reference herein.)

    10.13  Amendment Number 2 to Executive Deferral Plans II. (Filed as Exhibit 10.7 to ALZA's Annual Report on
           Form 10-K for the year ended December 31, 1994 (File No. 1-6247), and incorporated by reference herein.)

    10.14  ALZA Corporation Amended and Restated Stock Plan. (Filed as Exhibit 10.2 to ALZA's Quarterly Report on
           Form 10-Q for the quarter ended June 30, 1993 (File No. 1-6247), and incorporated by reference herein.)

    10.15  Form of Executive Agreement between ALZA Corporation and Certain Executive Officers. (Filed as Exhibit
           10.10 to ALZA's Annual Report on Form 10-K for the year ended December 31, 1995 (File No. 1-6247), and
           incorporated by reference herein.)

    10.16  Form of Amendment to Executive Agreement between ALZA Corporation and Certain Executive Officers dated
           as of June 11, 1999. (Filed as Exhibit 10.2 to ALZA's Quarterly Report on Form 10-Q for the quarter
           ended June 30, 1999 (File No. 1-6247), and incorporated by reference herein.)

    10.17  Executive Agreement between ALZA Corporation and Dr. Ernest Mario, dated as of June 21, 1999. (Filed as
           Exhibit 10.3 to ALZA's Quarterly Report on Form 10-Q for the quarter ended June 30, 1999 (File No.
           1-6247), and incorporated by reference herein.)

    23.1   Consent of Arthur Andersen LLP, independent public accountants to Abbott Laboratories.

    23.2   Consent of Ernst & Young LLP, independent auditors of ALZA Corporation.

    23.3   Consent of Mayer, Brown & Platt. (Included in Exhibit 5.1 hereto.)

    23.4   Consent of Heller Ehrman White & McAuliffe. (Included in Exhibit 8.1 hereto.)

    23.5   Consent of Chase Securities Inc.

    23.6   Consent of Merrill Lynch & Co.

    24.1   Power of Attorney of certain directors and officers of Abbott Laboratories. (Included on the signature
           page of this registration statement.)

    99.1   Form of Proxy Card.

    99.2   Co-Promotion Agreement between ALZA Corporation and Abbott Laboratories, dated as of June 21, 1999.
           (Filed as Exhibit 99.2 to ALZA's Current Report on Form 8-K filed June 25, 1999 (File No. 1-6247), and
           incorporated by reference herein.)

    99.3   Co-Promotion Agreement between ALZA Corporation and Abbott Laboratories, dated as of June 21, 1999.
           (Filed as Exhibit 99.3 to ALZA's Current Report on Form 8-K filed June 25, 1999 (File No. 1-6247), and
           incorporated by reference herein.)
</TABLE>

<PAGE>

                                                                     EXHIBIT 5.1

                           [LETTERHEAD]


                                                      August 16, 1999

Abbott Laboratories
100 Abbott Park Road
Abbott Park, Illinois 60064


         Re:      Merger of AC Merger Sub Inc., a wholly owned subsidiary
                  of Abbott Laboratories, with and into ALZA Corporation

Ladies and Gentlemen:

         We have acted as special counsel to Abbott Laboratories, an Illinois
corporation ("Abbott"), in connection with the corporate proceedings taken and
to be taken relating to the merger of AC Merger Sub Inc., a wholly owned
subsidiary of Abbott, with and into ALZA Corporation ("ALZA"), with ALZA being
the surviving corporation (the "Merger"), and conversion of each share of ALZA
Common Stock, par value $0.01 per share, issued and outstanding at the effective
time of the Merger into 1.2 Abbott common shares, without par value ("Abbott
Common Shares"). We have also participated in the preparation and filing with
the Securities and Exchange Commission under the Securities Act of 1933, as
amended, of a registration statement on Form S-4 (the "Registration Statement")
relating to the Merger. In this connection, we have examined such corporate and
other records, instruments, certificates and documents as we considered
necessary to enable us to express this opinion.

         Based on the foregoing, it is our opinion that the Abbott Common Shares
have been duly and validly authorized by all necessary action on the part of
Abbott and when issued pursuant to the terms of the Agreement and Plan of
Merger, dated as of June 21, 1999, will be validly issued, fully paid and
non-assessable by Abbott.

         We consent to the filing of this opinion as an exhibit to the
Registration Statement and to the reference to us under the caption "Additional
Information -- Legal Matters" therein.

                                                     Very truly yours,



                                                     /s/ MAYER, BROWN & PLATT
                                                     ------------------------
                                                     MAYER, BROWN & PLATT

PJN/SLS


<PAGE>

                                                                     EXHIBIT 8.1
                                 [LETTERHEAD]


                                August 16, 1999


ALZA Corporation
950 Page Mill Road
P.O. Box 10950
Palo Alto, CA  94303-0802


Ladies and Gentlemen:

         This opinion is being delivered to you in connection with the Form
S-4 Registration Statement (the "Registration Statement") filed pursuant to
the Agreement and Plan of Merger dated as of June 21, 1999 (the "Merger
Agreement") by and among ALZA Corporation, a Delaware corporation ("ALZA"),
Abbott Laboratories, an Illinois corporation ("Abbott"), and AC Merger Sub
Inc. ("Merger Sub"), a wholly owned subsidiary of Abbott.

         Except as otherwise provided, capitalized terms used but not defined
herein shall have the meanings set forth in the Agreement and Plan of Merger
dated as of June 21, 1999 (the "Merger Agreement") by and among Abbott,
Merger Sub, and ALZA. All "section" references, unless otherwise indicated,
are to the Internal Revenue Code of 1986, as amended (the "Code").

         We have acted as tax counsel to ALZA in connection with the Merger.
As such, and for the purpose of rendering this opinion, we have examined, and
are relying upon (without any independent investigation or review thereof)
the truth and accuracy at all relevant times (including without limitation
the Effective Time) of, the statements, covenants, representations, and
warranties contained in the following documents (including all exhibits and
schedules attached thereto):

<PAGE>

Page 2


         (a)      the Merger Agreement;

         (b)      those tax representation letters delivered to us by Abbott,
Merger Sub and ALZA pursuant to the Merger Agreement (the "Tax Representation
Letters");

         (c)      the Registration Statement; and

         (d)      such other instruments and documents related to the
formation, organization, and operation of Abbott, Merger Sub, and ALZA and
related to the consummation of the Merger and the other transactions
contemplated by the Merger Agreement as we have deemed necessary or
appropriate.

         In connection with rendering this opinion, we have assumed (without
any independent investigation or review thereof) that:

         (a)      Original documents submitted to us (including signatures
thereto) are authentic, documents submitted to us as copies conform to the
original documents, and all such documents have been (or will be by the
Effective Time) duly and validly executed and delivered where due execution
and delivery are a prerequisite to the effectiveness thereof;

         (b)      All representations, warranties, and statements made or
agreed to by Abbott, Merger Sub, and ALZA, their managements, employees,
officers, and directors in connection with the Merger, including but not
limited to, those set forth or described in the Merger Agreement (including
the exhibits thereto), the Registration Statement, and the Tax Representation
Letters are true and accurate at all relevant times;

         (c)      All covenants contained in the Merger Agreement (including
exhibits thereto) and the Tax Representation Letters are performed without
waiver or breach of any material provision thereof;

         (d)      The Merger will be reported by Abbott, Merger Sub, and ALZA
on their respective federal income tax returns in a manner consistent with
the opinion set forth below;

         (e)      Any representation or statement made "to the best of
knowledge" or similarly qualified is correct without such qualification;

<PAGE>

Page 3

         (f)      The Registration Statement, the Merger Agreement, and the
Tax Representation Letters reflect all the material facts relating to the
Merger, Abbott, Merger Sub, and ALZA;

         (g)      The Merger will qualify as a statutory merger under the
laws of the State of Delaware; and

         (h)      As to all matters as to which any person or entity
represents that it is not a party to, does not have, or is not aware of any
plan, intention, understanding or agreement, there is in fact no such plan,
intention, understanding or agreement.

         Regarding the status of ALZA's LYONs as debt, rather than equity,
for federal income tax purposes, we (with ALZA's consent) assume the
correctness of Mayer, Brown & Platt's tax opinion to ALZA dated May 16, 1994,
rendered in Mayer, Brown & Platt's then-capacity as special tax counsel to
ALZA in connection with the issuance of ALZA's Liquid Yield Option Notes
("LYONs") due to mature on July 14, 2014, to the effect that the LYONs
constitute debt for federal income tax purposes.

         Based on our examination of the foregoing items and subject to the
limitations, qualifications, and assumptions set forth herein, we are of the
opinion that:

         1.       If the Merger is consummated in accordance with the Merger
Agreement, for United States federal income tax purposes: (a) the Merger will
be a reorganization within the meaning of Section 368(a)(1) of the Code, and
(b) Abbott, Merger Sub, and ALZA will each be a party to that reorganization
within the meaning of Section 368(b) of the Code.

         2.       The discussion entitled "Material Federal Income Tax
Consequences" set forth in the Registration Statement, insofar as it relates
to statements of law and legal conclusions, is correct in all material
respects.

         This opinion is limited to the federal income tax consequences of
the Merger and does not address the various state, local, or foreign tax
consequences that may result from the Merger or the other transactions
contemplated by the Merger Agreement. In addition, no opinion is expressed as
to any federal income tax consequence of the Merger or the other transactions
contemplated by the Merger Agreement except as specifically set forth herein,
and this opinion may not be relied upon except with respect to the
consequences specifically discussed herein. No opinion is expressed as to the
federal income tax


<PAGE>

Page 4

treatment that may be relevant to a particular investor in light of personal
circumstances or to certain types of investors subject to special treatment
under the federal income tax laws (for example, life insurance companies,
dealers in securities, taxpayers subject to the alternative minimum tax in
the year in which the Merger occurs, banks, tax-exempt organizations,
non-United States persons, stockholders who exercise dissenter's rights, and
stockholders who acquired their shares of ALZA stock pursuant to the exercise
of options or otherwise as compensation or who hold their ALZA stock as part
of a straddle or risk reduction transaction). To the extent that any of the
representations, warranties, statements, and assumptions material to our
opinion and upon which we have relied are not accurate and complete in all
material respects at all relevant times, our opinion could be adversely
affected and should not be relied upon.

         This opinion is not binding on the Internal Revenue Service or any
court of law, administrative agency or other governmental body and represents
only our judgment as to the likely outcome if the federal income tax
consequences of the Merger were properly presented to a court of competent
jurisdiction. Our conclusions are based on the Code, existing judicial
decisions, administrative regulations, and published rulings as in effect on
the date hereof. No assurance can be given that future legislative, judicial,
or administrative changes or interpretations will not adversely affect the
accuracy of our conclusions. Nevertheless, by rendering this opinion, we
undertake no responsibility to advise you of any new developments in the
application or interpretation of the federal income tax laws.

         We consent to the reference to our firm under the caption "Material
Federal Income Tax Consequences" in the Proxy Statement included in the
Registration Statement and to the reproduction and filing of this opinion as
an exhibit to the Registration Statement. In giving this consent, however, we
do not admit that we are in the category of persons whose consent is required
under Section 7 of the Securities Act of 1933, as amended.

                                       Very truly yours,


                                       /s/ HELLER EHRMAN WHITE & MCAULIFFE

<PAGE>


                                                               EXHIBIT 23.1


CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

As independent public accountants, we hereby consent to the incorporation by
reference in this registration statement of our reports dated January 14,
1999, included and incorporated by reference in Abbott Laboratories' Form 10-K
for the year ended December 31, 1998 and to all references to our Firm
included in this registration statement.


                                      /s/ Arthur Andersen LLP
Arthur Andersen LLP
Chicago, Illinois
August 13, 1999


<PAGE>

                                                                  EXHIBIT 23.2



                 CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

     We consent to the reference to our firm under the caption "Experts" in
the Proxy Statement of ALZA Corporation that is made a part of the
Registration Statement (Form S-4) and related Prospectus of Abbott
Laboratories for the registration of shares of its common stock to be issued
pursuant to the merger of ALZA Corporation with Abbott Laboratories and to
the incorporation by reference therein of our reports (a) dated January 29,
1999, except for Note 12 as to which date is March 16, 1999, with respect to
the consolidated financial statements and schedule of ALZA Corporation
included in its Annual Report (Form 10-K/A) for the year ended December 31,
1998 and (b) dated January 29, 1999, except for paragraph 2 of Note 1 and
Note 12 as to which date is March 16, 1999, with respect to the restated
consolidated financial statements and schedule of ALZA Corporation included
in its Current Report (Form 8-K), dated May 12, 1999, filed with the
Securities and Exchange Commission.

                                  ERNST & YOUNG LLP






Palo Alto, California
August 13, 1999

<PAGE>


                                                           EXHIBIT 23.5

                        CONSENT OF CHASE SECURITIES INC.


                                                         August 16, 1999


Board of Directors
ALZA Corporation
950 Page Mill Road
Palo Alto, CA 94304

Members of the Board:

     We hereby consent to the use of our opinion letter dated June 21, 1999
to the Board of Directors of ALZA Corporation ("ALZA"), included as Annex B
to the Proxy Statement/Prospectus which forms a part of the Registration
Statement on Form S-4 relating to the proposed merger of AC MERGER SUB INC.,
a wholly owned subsidiary of Abbott Laboratories, with and into ALZA, and to
the references therein to such opinion in the sections entitled
"Summary--Opinions of the Financial Advisors to ALZA's Board of Directors,"
"The Merger Agreement and the Merger--Reasons for the Merger; Recommendation
of ALZA's Board of Directors," "The Merger Agreement and the Merger--Opinion
of Chase Securities Inc. to ALZA's Board of Directors" and "The Merger
Agreement and the Merger--Representations and Warranties."

     In giving such consent, we do not admit that we come within the category
of persons whose consent is required under Section 7 of the Securities Act of
1933, as amended, or the rules and regulations of the Securities and
Exchange Commission thereunder, nor do we thereby admit that we are experts
with respect to any part of such Registration Statement within the meaning of
the term "experts" as used in the Securities Act of 1933, as amended, or
the rules and regulations of the Securities and Exchange Commission
thereunder.


                                       CHASE SECURITIES INC.

                                       By: /s/ ANDREW WEISENFELD
                                           ---------------------

                                       Name: Andrew Weisenfeld

                                       Title: Vice President



<PAGE>

EXHIBIT 23.6

ALZA Corporation
950 Page Mill Road
Palo Alto, CA 94304

     We hereby consent to the use of our opinion letter dated June 21, 1999 to
the Board of Directors of ALZA Corporation included as Annex C to the Proxy
Statement/Prospectus which forms a part of the Registration Statement on Form
S-4 relating to the proposed merger of AC Merger Sub Inc., a wholly owned
subsidiary of Abbott Laboratories, with and into ALZA Corporation and to the
references to such opinion in such Proxy Statement/Prospectus under the
captions "Summary--Opinions of the Financial Advisors to ALZA's Board of
Directors," "The Merger Agreement and the Merger--Reasons for the Merger;
Recommendation of ALZA's Board of Directors," "--Opinion of Merrill
Lynch & Co. to ALZA's Board of Directors'' and "--Representations and
Warranties." In giving such consent, we do not admit and we hereby disclaim
that we come within the category of persons whose consent is required under
Section 7 of the Securities Act of 1933, as amended, or the rules and
regulations of the Securities and Exchange Commission thereunder, nor do we
thereby admit that we are experts with respect to any part of such
Registration Statement within the meaning of the term "experts" as used in
the Securities Act of 1933, as amended, or the rules and regulations of
the Securities and Exchange Commission thereunder.

Merrill Lynch, Pierce, Fenner & Smith
Incorporated



August 16, 1999


<PAGE>
ALZA CORPORATION
c/o EquiServe
P.O. Box 8040
Boston, MA 02266-8040

________________________________________________________________________________
/X/ PLEASE MARK VOTE AS IN THIS EXAMPLE.

<TABLE>
<S>                                                                   <C>         <C>         <C>
      THE BOARD OF DIRECTORS OF ALZA CORPORATION UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE PROPOSAL.

To adopt the Agreement and Plan of Merger among ALZA Corporation,        FOR       AGAINST     ABSTAIN
Abbott Laboratories and AC Merger Sub Inc. dated as of June 21,          / /         / /         / /
1999, as the same may be amended from time to time, and to approve
the merger contemplated under that agreement.

To transact such other business related to matters as may properly
come before the special meeting or any adjournments or postponements
thereof.
</TABLE>

                            MARK HERE FOR ADDRESS CHANGE AND NOTE AT LEFT / /

                              Please date and sign exactly as name(s) appear(s)
                              hereon. If shares are held jointly, each holder
                              should sign. Please give full title and capacity
                              in which signing if not signing as an individual
                              stockholder.

Signature: __________    Date: ________   Signature: __________   Date: ________
<PAGE>
________________________________________________________________________________
                                     PROXY

                                ALZA CORPORATION

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

    The undersigned hereby appoint(s) Julian N. Stern, Peter D. Staple and Bruce
C. Cozadd, or any of them, each with full power of substitution, the lawful
attorneys and proxies of the undersigned to attend the Special Meeting of
Stockholders of ALZA Corporation (or any adjournments or postponements thereof)
to be held on Tuesday, September 21, 1999 or at a later time if the Special
Meeting is adjourned or postponed, to vote the number of shares the undersigned
would be entitled to vote if personally present, and to vote in their discretion
upon any other business that may properly come before the meeting or any
adjournments or postponements thereof.

    THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED BY
THE UNDERSIGNED STOCKHOLDER(S). IF NO DIRECTION IS MADE, THIS PROXY WILL BE
VOTED "FOR" THE PROPOSAL. THIS PROXY MAY BE REVOKED AT ANY TIME PRIOR TO THE
TIME IT IS VOTED BY ANY MEANS DESCRIBED IN THE ACCOMPANYING PROXY
STATEMENT/PROSPECTUS.

<TABLE>
<S>              <C>                                                                       <C>
      SEE                                                                                        SEE
    REVERSE                     CONTINUED AND TO BE SIGNED ON REVERSE SIDE                     REVERSE
     SIDE                                                                                       SIDE
</TABLE>


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission