RHONE POULENC RORER INC
S-8, 1996-12-24
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
   As filed with the Securities and Exchange Commission on December 23, 1996
                                                            Registration No. 33-
================================================================================

                      SECURITIES AND EXCHANGE COMMISSION
                             Washington, DC  20549
                             ---------------------
                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933
                             ---------------------

                           RHONE-POULENC RORER INC.
            (Exact name of registrant as specified in its charter)

        Pennsylvania                                   23-1699163
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
incorporation or organization)

        500 Arcola Road
        Collegeville, PA                                 19426-0107
(Address of principal executive offices)                 (Zip Code)


                           RHONE-POULENC RORER INC.
                         1995 EQUITY COMPENSATION PLAN
                           (Full title of the plan)

                           RICHARD T. COLLIER, ESQ.
                           Rhone-Poulenc Rorer Inc.
                                500 Arcola Road
                         Collegeville, PA  19426-0107
                    (Name and address of agent for service)
                                (610) 454-8000
         (Telephone number, including area code, of agent for service)
                            -----------------------
                        Copy of all communications to:
                            JAMES W. JENNINGS, ESQ.
                          Morgan, Lewis & Bockius LLP
                             2000 One Logan Square
                            Philadelphia, PA  19103
                                (215) 963-5726

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
 Title of securities   Amount to be  Proposed maximum    Proposed maximum      Amount of
  to be registered      registered    offering price        aggregate       registration fee
                                       per share (1)    offering price (1)
- --------------------------------------------------------------------------------------------
<S>                    <C>           <C>                <C>                 <C>
Common Stock,             5,000,000           $74.813        $374,065,000           $113,354
 without par value
- --------------------------------------------------------------------------------------------
</TABLE>

(1)  Estimated pursuant to paragraphs (c) and (h) of Rule 457 solely for the
     purpose of calculating the registration fee, based upon the average of the
     high and low sales prices of shares of Common Stock on December 18, 1996,
     as reported on the New York Stock Exchange.
<PAGE>
 
     This Registration Statement on Form S-8 (the "Registration Statement")
     filed by Rhone-Poulenc Rorer Inc. (the "Registrant") relates to 5,000,000
     shares (the "Shares") of the Company's Common Stock, without par value (the
     "Common Stock"), issuable pursuant to the Rhone-Poulenc Rorer Inc. 1995
     Equity Compensation Plan (the "Plan").

                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

     Item 3.  Incorporation of Documents by Reference.
              --------------------------------------- 

               The following documents, as filed by the Registrant with the
     Securities and Exchange Commission (the "Commission"), are incorporated by
     reference in this Registration Statement:

               (a)  Annual Report on Form 10-K, filed with the Commission on
          March 18, 1996 for the fiscal year ended December 31, 1995;

               (b)  Quarterly Report on Form 10-Q filed with the Commission on
          May 10, 1996 for the quarter ended March 31, 1996;

               (c)  Quarterly Report on Form 10-Q filed on August 13, 1996 for
          the quarter ended June 30, 1996;

               (d)  Quarterly Report on Form 10-Q filed on November 6, 1996 for
          the quarter ended September 30, 1996;

               (e)   Proxy Statement for the Annual Meeting of Stockholders held
          on May 3, 1996; and

               (f)  The descriptions of the Common Stock of the Registrant set
          forth in the Registrant's Registration Statements pursuant to Section
          12 of the Exchange Act, and any amendment or report filed for the
          purpose of updating such description.

               All reports and other documents filed by the Registrant and the
     Plan pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities
     Exchange Act of 1934, after the date of this registration statement and
     prior to the filing of a post-effective amendment that indicates that all
     securities offered hereby have been sold or that deregisters all securities
     then remaining unsold, shall be deemed to be incorporated by reference
     herein and to be part hereof from the date of filing of such documents.

               Any statement contained in a document incorporated by reference
     herein shall be deemed to be modified or superseded for purposes hereof to
     the extent that a statement contained herein (or in any other subsequently
     filed document that is also incorporated by reference herein) modifies or
     supersedes such statement. Any such statement so modified or superseded
     shall not be deemed, except as so modified or superseded, to constitute a
     part hereof.

     Item 4.  Description of Securities.
              ------------------------- 

               Not applicable.

                                       1
<PAGE>
 
     Item 5.  Interests of Named Experts and Counsel.
              -------------------------------------- 

               The consolidated financial statements of the Registrant and its
     subsidiaries included in the Registrant's Report on Form 10-K for the
     fiscal year ending December 31, 1995 and incorporated by reference in this
     registration statement have been audited by Coopers & Lybrand LLP,
     independent accountants, as set forth in their report contained therein.
     Such financial statements are, and audited annual financial statements to
     be included in subsequently filed documents will be, incorporated herein in
     reliance upon the reports of Coopers & Lybrand LLP pertaining to such
     financial statements (to the extent covered by consents filed with the
     Securities and Exchange Commission) given upon the authority of such firm
     as experts in accounting and auditing.

     Item 6.  Indemnification of Directors and Officers.
              ----------------------------------------- 

               Section 1741 of the Pennsylvania Business Corporation Law (the
     "PBCL") provides the Company the power to indemnify any officer or director
     acting in his or her capacity as a representative of the Company who was or
     is a party or is threatened to be made a party to any action or proceeding
     against expenses, judgments, penalties, fines and amounts paid in
     settlement in connection with such action or proceeding whether the action
     was instituted by a third party or arose by or in the right of the Company.
     Generally, the only limitation on the ability of the Company to indemnify
     its officers and directors is if the act violates a criminal statute or if
     the act or failure to act is finally determined by a court to have
     constituted willful misconduct or recklessness.

               The Bylaws of the Registrant provide that the Registrant shall
     indemnify any and all directors and officers of the Registrant and any
     other person designated as an "indemnified representative" by the board of
     directors of the Registrant (which may, but need not, include any person
     serving at the request of the Registrant, as a director, officer, fiduciary
     or trustee of another corporation, partnership, joint venture, trust,
     employee benefit plan or other entity or enterprise) (each, an "indemnified
     representative") against any liability incurred in connection with any
     threatened, pending or completed action, suit, appeal or other proceeding
     of any nature, whether civil, criminal, administrative or investigative,
     whether formal or informal, and whether brought by or in the right of the
     Registrant, a class of its security holders or otherwise (each, a
     "Proceeding") in which the indemnified representative may be involved as a
     party or otherwise, by reason of the fact that such person is or was
     serving in an indemnified capacity, including without limitation
     liabilities resulting from any actual or alleged breach or neglect of duty,
     error, misstatement or misleading statement, negligence, gross negligence
     or act giving rise to strict or products liability, except where such
     indemnification is expressly prohibited by applicable law or where conduct
     of the indemnified representative has been determined (as provided in the
     Bylaws) to constitute willful misconduct or recklessness or unlawful self-
     dealing, sufficient in the circumstances to bar indemnification against
     liabilities arising from the conduct.  If an indemnified representative is
     entitled to indemnification in respect of a portion, but not all, of any
     liabilities to which such person may be subject, the Registrant shall
     indemnify such indemnified representative to the maximum extent for such
     portion of the liabilities.  The termination of a Proceeding by judgment,
     order, settlement, conviction or upon a plea of nolo contendre or its
     equivalent shall not, of itself, create a presumption that the indemnified
     representative is not entitled to indemnification.   The Bylaws provide for
     the advancement of expenses to an indemnified party upon receipt of an
     undertaking by the party to repay those amounts if it is finally determined
     that the indemnified party is not entitled to indemnification.

               An indemnified representative shall be deemed to have discharged
     such person's duty to the Registrant if he or she has relied in good faith
     on information, opinions, reports or statements, including financial
     statements and other financial data, in each case prepared or presented by
     any of the following:

               (1)  one or more officers or employees of the Registrant whom the
          indemnified representative reasonably believes to be reliable and
          competent with respect to the matter presented;

               (2)  legal counsel, public accountants or other persons as to
          matters that the indemnified representative reasonably believes are
          within the person's professional or expert competence; or

                                       2
<PAGE>
 
               (3)  a committee of the board of directors on which he or she
          does not serve as to matters within its area of designated authority,
          which committee he or she reasonably believes to merit confidence.

               The Bylaws authorize the Company to take steps to ensure that all
     persons entitled to indemnification are properly indemnified, including, if
     the board of directors so determines, purchasing and maintaining insurance.
     The Company currently maintains directors and officers insurance.


     Item 7.  Exemption from Registration Claimed.
              ----------------------------------- 

                 Not applicable.


     Item 8.  Exhibits.
              -------- 

               The exhibits filed as part of this Registration Statement are as
     follows:

     Exhibit
     Number                     Exhibit
     ------                     -------

      5          Opinion re legality

     23.1        Consent of Coopers & Lybrand LLP

     23.2        Consent of Richard T. Collier, Senior Vice President and
                 General Counsel of the Registrant   (included in Exhibit 5)

     24          Power of Attorney

     99          Rhone-Poulenc Rorer Inc. 1995 Equity Compensation Plan


     Item 9.  Undertakings.
              ------------ 

               The undersigned Registrant hereby undertakes:

               (1)  To file, during any period in which offers or sales are
     being made, a post-effective amendment to this registration statement to
     include any prospectus required by Section 10(a)(3) of the Securities Act
     of 1933;

               (i)  To include any prospectus required by Section 10(a)(3) of
          the Securities Act of 1933;

               (ii)  To reflect in the prospectus any facts or events arising
          after the effective date of the registration statement (or the most
          recent post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in the registration statement; and

               (iii)  To include any material information with respect to the
          plan of distribution not previously disclosed in the registration
          statement or any material change to such information in the
          registration statement;

                                       3
<PAGE>
 
               Provided, however, that subparagraphs (a)(1)(i) and (a)(1)(ii) of
               --------  -------                                                
     this section do not apply if the information required to be included in a
     post-effective amendment by those subparagraphs is contained in periodic
     reports filed by the Registrant pursuant to Section 13 or Section 15(d) of
     the Securities Exchange Act of 1934 that are incorporated by reference in
     the registration statement.

               (2)  That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.

               (3)  To remove from registration by means of a post-effective
     amendment any of the securities being registered that remain unsold at the
     termination of the offering.

               The undersigned Registrant hereby undertakes that, for the
     purpose of determining any liability under the Securities Act of 1933, each
     filing of the Registrant's annual report pursuant to Section 13(a) or
     Section 15(d) of the Securities Exchange Act of 1934 (and each filing of an
     employee benefit plan's annual report pursuant to Section 15(d) of the
     Securities Exchange Act of 1934) that is incorporated by reference in this
     registration statement shall be deemed to be a new registration statement
     relating to the securities offered herein and the offering of such
     securities at that time shall be deemed to be the initial bona fide
     offering thereof.

               Insofar as indemnification for liabilities arising under the
     Securities Act of 1933 may be permitted to directors, officers and
     controlling persons of the Registrant pursuant to the foregoing provisions,
     or otherwise, the Registrant has been advised that in the opinion of the
     Securities and Exchange Commission such indemnification is against public
     policy as expressed in the Act and is, therefore, unenforceable.  In the
     event that a claim for indemnification against such liabilities (other than
     the payment by the Registrant of expenses incurred or paid by a director,
     officer or controlling person of the Registrant in the successful defense
     of any action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.

                                       4
<PAGE>
 
                                   SIGNATURES

               The Registrant.  Pursuant to the requirements of the Securities
               --------------                                                 
     Act of 1933, the Registrant certifies that it has reasonable grounds to
     believe that it meets all of the requirements for filing on Form S-8 and
     has duly caused this Registration Statement to be signed on its behalf by
     the undersigned, thereunto duly authorized, in Collegeville, Pennsylvania,
     on the 20th day of December, 1996.

                                RHONE-POULENC RORER INC.


                                By:   /s/ Michel de Rosen
                                      -----------------------------------------
                                      MICHEL DE ROSEN
                                      President and Chief Executive Officer



               Pursuant to the requirements of the Securities Act 1933, this
     Registration Statement has been signed below by the following persons in
     the capacities and on the date indicated.

<TABLE>
<CAPTION>
           Signature                            Capacity                      Date
           ---------                            --------                      ----       
<S>                               <C>                                   <C>
                                  Director
- --------------------------------
Jean-Marc Bruel

/s/ Jean-Jacques Bertrand*        Director                              December 20, 1996
- --------------------------------
Jean-Jacques Bertrand

/s/ Robert E. Cawthorn*           Director                              December 20, 1996
- --------------------------------
Robert E. Cawthorn

/s/ Michel de Rosen               Chairman and Chief Executive Officer  December 20, 1996
- --------------------------------  Director
Michel de Rosen

/s/ Charles-Henri Filippi*        Director                              December 20, 1996
- --------------------------------
Charles-Henri Filippi

/s/ Dale F. Frey*                 Director                              December 20, 1996
- --------------------------------
Dale F. Frey

/s/ Claude Helene*                Director                              December 20, 1996
- --------------------------------
Claude Helene

                                  Director
- --------------------------------
Michael H. Jordan

/s/ Manfred E. Karobath, M.D.*    Director                              December 20, 1996
- --------------------------------
Manfred E. Karobath, M.D.

/s/ Igor Landau*                  Director                              December 20, 1996
- --------------------------------
Igor Landau

/s/ Patrick Langlois              Executive Vice President and          December 20, 1996
- --------------------------------  Chief Financial Officer
Patrick Langlois

/s/ Philippe Maitre               Vice President and Controller         December 20, 1996
- --------------------------------  (Principal Accounting Officer)
Philippe Maitre
 
</TABLE>

                                       5
<PAGE>
 
<TABLE>
<CAPTION>
         Signature                           Capacity                           Date
         ---------                           --------                           ----
<S>                               <C>                                   <C>
/s/ Peter J. Neff*
- --------------------------------  Director                              December 20, 1996
Peter J. Neff

/s/ James S. Riepe*               Director                              December 20, 1996
- --------------------------------
James S. Riepe

/s/ Jean-Pierre Tirouflet*        Director                              December 20, 1996
- --------------------------------
Jean-Pierre Tirouflet
</TABLE>


* By:  /s/ Richard T. Collier
      --------------------------------------
      RICHARD T. COLLIER
      Senior Vice President and
      General Counsel
      (Attorney-in-fact)

                                       6
<PAGE>
 
                               INDEX TO EXHIBITS

<TABLE>
<CAPTION>

                                                                            Sequentially
     Exhibit                                                                  Numbered
     Number                     Exhibit                                         Page
     -------                    -------                                         ----
     <S>         <C>                                                        <C>
       5         Opinion re legality

      23.1       Consent of Coopers & Lybrand LLP

      23.2       Consent of Richard T. Collier, Senior Vice President and
                 General Counsel of the Registrant (included in Exhibit 5)

      24         Power of Attorney

      99         Rhone-Poulenc Rorer Inc. 1995 Equity Compensation Plan
</TABLE>
        

<PAGE>
 
                                                                       Exhibit 5
                                                                       ---------

                               December 23, 1996



     Rhone-Poulenc Rorer Inc.
     500 Arcola Road
     Collegeville, PA 19426-0107

     Ladies/Gentlemen:

               Rhone-Poulenc Rorer Inc. (the "Company") has requested my
     opinion, as General Counsel of the Company, in connection with the
     Registration Statement on Form S-8 to be filed by the Company with the
     Securities and Exchange Commission under the Securities Act of 1933, as
     amended, and the rules and regulations promulgated thereunder (the "Act"),
     with respect to 5,000,000 shares of the Company's Common Stock, without par
     value (the "Shares"), which are issuable pursuant to the Rhone-Poulenc
     Rorer Inc. 1995 Equity Compensation Plan (the "Plan").

               I or attorneys under my supervision have examined such records
     and have made such examination of law as I deem appropriate in connection
     with rendering such opinion.  I have also assumed that the registration
     provisions of the Act and of such securities or "Blue Sky" laws as may be
     applicable shall have been complied with.  Based thereon, it is my opinion
     that, when issued and delivered in accordance with the provisions of the
     Plan, the Shares will be legally issued, fully paid and non-assessable.

               I hereby consent to the filing of this opinion as an Exhibit to
     the Registration Statement.  In giving this consent I do not admit that I
     am in the category of persons whose consent is required under Section 7 for
     the Securities Act of 1933 or the rules and regulations for the Securities
     and Exchange Commission thereunder.



                                             /s/ Richard T. Collier
                                             -----------------------------------
                                             Richard T. Collier
                                             Senior Vice President and
                                             General Counsel

<PAGE>
 
                                                                    Exhibit 23.1
                                                                    ------------

                      CONSENT OF INDEPENDENT ACCOUNTANTS


     We consent to the incorporation by reference in this Registration Statement
     of Rhone-Poulenc Rorer, Inc. on Form S-8 of our report dated January 26,
     1996 on our audits of the consolidated financial statements of
     Rhone-Poulenc Rorer, Inc. as of December 31, 1995 and 1994 and for the
     years ended December 31, 1995, 1994, and 1993, which report is included in
     the Company's Annual Report on Form 10-K for the year ended December 31,
     1995. We consent to the references to our firm under the caption "Experts."
              


     COOPERS & LYBRAND LLP

     /s/ Coopers & Lybrand LLP

     Philadelphia, Pennsylvania

     December 23, 1996

                

<PAGE>
 
                                                                      Exhibit 24
                                                                      ----------

                               POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each of the undersigned, does hereby
     nominate, constitute and appoint Richard B. Young, Richard T. Collier and
     Patrick Langlois, or any of them, as his agent and attorney-in-fact, in his
     name to execute on behalf of the undersigned a Registration Statement on
     Form S-8 to be filed with the Securities and Exchange Commission under the
     Securities Act of 1933, as amended, in connection with the registration
     under said Act of shares of Common Stock of Rhone-Poulenc Rorer Inc. (the
     "Company"), the authority herein given to include execution of amendments
     to any part of such Registration Statement and generally to do and perform
     all things necessary to be done in the premises as fully and effectively in
     all respects as the undersigned could do if personally present.

     IN WITNESS WHEREOF, this power of attorney has been executed in
     counterparts by individuals listed below as of the 30th day of October
     1996.

/s/ Jean-Marc Bruel          /s/ Manfred E. Karobath, M.D.
- ---------------------------  -----------------------------
     Jean-Marc Bruel            Manfred E. Karobath, M.D.

/s/ Jean-Jacques Bertrand
- ---------------------------  -----------------------------
   Jean-Jacques Bertrand           Michael H. Jordan
                         
/s/ Robert E. Cawthorn       /s/ Igor Landau
- ---------------------------  -----------------------------
     Robert E. Cawthorn               Igor Landau
                   
/s/ Michel de Rosen          /s/ Peter J. Neff
- ---------------------------  -----------------------------
      Michel de Rosen                Peter J. Neff
                      
/s/ Charles-Henri Filippi    /s/ James S. Riepe
- ---------------------------  -----------------------------
   Charles-Henri Filippi            James S. Riepe
                      
/s/ Dale F. Frey             /s/ Jean-Pierre Tirouflet
- ---------------------------  -----------------------------
       Dale F. Frey              Jean-Pierre Tirouflet
             
/s/ Claude Helene
- ---------------------------
      Claude Helene
 

<PAGE>
 
                                                                      Exhibit 99
                                                                      ----------


                            RHONE-POULENC RORER INC.
                         1995 EQUITY COMPENSATION PLAN
                         -----------------------------

               [Amended and Restated Effective November 1, 1996]


               The purpose of the Rhone-Poulenc Rorer Inc. 1995 Equity
     Compensation Plan (the "Plan") is (i) to authorize the Executive Personnel
     and Compensation Committee (the "Committee") of the Board of Directors to
     provide designated officers (including officers who are also directors),
     other employees and directors who are not employees ("Non-Employee
     Directors") of Rhone-Poulenc Rorer Inc. and its subsidiaries (hereinafter
     collectively referred to as the "Company") and principals of organizations
     involved with the Company on significant projects ("Key Advisors") with
     certain rights to acquire common stock of the Company and (ii) to provide
     for the grant of incentive stock options, nonqualified stock options and
     stock appreciation rights.  The Company believes that the Plan will cause
     the participants to contribute materially to the growth of the Company,
     thereby benefitting the Company's shareholders and will align the economic
     interests of the participants with those of the shareholders.  This Plan
     shall serve as the successor equity incentive program to the Rorer Group
     Inc. Equity Compensation Plan.

               1.   Administration
                    --------------

               The Plan shall be administered and interpreted by a committee
     (the "Committee") consisting of not less than two persons appointed by the
     Board of Directors of the Company, all of whom shall be non-employee
     directors as defined under Rule 16b-3 under the Securities Exchange Act of
     1934 (the "Exchange Act") and "outside directors" as defined under Section
     162(m) of the Internal Revenue Code of 1986, as amended (the "Code") and
     related Treasury regulations.  The Committee shall have the sole authority
     to determine (i) the employees and Key Advisors to whom options and awards
     shall be granted under the Plan, (ii) the type, size and terms of the
     awards to be made to each such individual, (iii) the time when the awards
     will be granted and the duration of the exercise period and (iv) any other
     matters arising under the Plan.  Non-Employee Directors shall receive
     grants only pursuant to the provisions of Section 6.  The Committee shall
     have full power and authority to administer and interpret the Plan, to make
     factual determinations and to adopt or amend such rules, regulations,
     agreements and instruments for implementing the Plan and for conduct of its
     business as it deems necessary or advisable, in its sole discretion.  The
     Committee's interpretations of the Plan and all determinations made by the
     Committee pursuant to the powers vested in it hereunder shall be conclusive
     and binding on all persons having any interests in the Plan or in any
     awards granted hereunder.  All powers of the Committee shall be executed in
     its sole discretion, in the best interest of the Company and in keeping
     with the objectives of the Plan and need not be uniform as to similarly
     situated individuals. Notwithstanding the foregoing, administration of
     Section 6 with respect to nondiscretionary

                                       1
<PAGE>
 
     grants to Non-Employee Directors is intended to be self-executing in
     accordance with the express terms and conditions of Section 6.  However, to
     the extent that administrative determinations are required with respect to
     Section 6, such determinations shall be made by the members of the Board
     who are not eligible to receive grants under Section 6, but in no event
     shall such determinations affect the eligibility of optionees, the
     determination of the exercise price, the timing of the grants or the number
     of shares subject to such grants.

               2.   Grants
                    ------

               Incentives under the Plan shall consist of incentive stock
     options, nonqualified stock options, restricted stock grants and stock
     appreciation rights (hereinafter collectively referred to as "Grants").
     All Grants shall be subject to the terms and conditions set forth herein
     and to those other terms and conditions consistent with this Plan as the
     Committee deems appropriate and as are specified in writing by the
     Committee to the employee (the "Grant Letter").  The Committee shall
     approve the form and provisions of each Grant Letter to an employee or Key
     Advisor.  Grants under a particular Section of the Plan need not be uniform
     as among the employees or Key Advisors and Grants under two or more
     Sections of the Plan may be combined in one instrument; provided, however,
     that Grants to Non-Employee Directors shall be made only in accordance with
     the provisions of Section 6.

               3.   Shares Subject to the Plan
                    --------------------------

               (a) Subject to the adjustment specified below, the aggregate
     number of shares of common stock of the Company ("Company Stock") that have
     been or may be issued or transferred under the Plan is 5,000,000 shares.
     During the term of the Plan, the maximum aggregate number of shares of
     Company Stock that shall be subject to options or awards under the Plan to
     any single individual shall be 500,000 shares.  The shares may be
     authorized but unissued shares of Company Stock or reacquired shares of
     Company Stock, including shares repurchased by the Company on the open
     market.  If and to the extent options or stock appreciation rights granted
     under the Plan terminate, expire, or are canceled, forfeited, exchanged or
     surrendered without having been exercised, or if any shares of restricted
     stock are forfeited, the shares subject to such option or such award shall
     again be available for purposes of the Plan.

               (b) If there is any change in the number or kind of shares of
     Company Stock outstanding (i) by reason of a stock dividend, spinoff,
     recapitalization, stock split, or combination or exchange of shares, (ii)
     by reason of a merger, reorganization or consolidation in which the Company
     is the surviving corporation, (iii) by reason of a reclassification or
     change in par value, or (iv) by reason of any other extraordinary or
     unusual event affecting the outstanding Company Stock as a class without
     the Company's receipt of consideration, or if the value of outstanding
     shares of Company Stock is substantially reduced as a result of a spinoff
     or the Company's payment of an extraordinary dividend or distribution, the
     maximum number of shares of Company Stock available for Grants, the maximum
     number of shares of Company Stock that any individual participating in the
     Plan may be granted in any

                                       2
<PAGE>
 
     year, the number of shares covered by outstanding Grants, the kind of
     shares issued under the Plan, and the price per share or the applicable
     market value of such Grants may be proportionately adjusted by the
     Committee to reflect any increase or decrease in the number or kind of
     issued shares of Company Stock to preclude the enlargement or dilution of
     rights and benefits under such Grants; provided, however, that any
     fractional shares resulting from such adjustment shall be eliminated.  The
     adjustments determined by the Committee shall be final, binding and
     conclusive.

               4.   Eligibility for Participation
                    -----------------------------

               Officers and other employees of the Company, Key Advisors
     designated by the Committee and Non-Employee Directors shall be eligible to
     participate in the Plan (hereinafter referred to individually as the
     "Participant" and collectively as the "Participants"), provided that Key
     Advisors and Non-Employee Directors shall not be eligible to receive
     Incentive Stock Options (as defined in Election 5(b) below).  The Committee
     shall select the employees and Key Advisors to receive Grants (together
     with Non-Employee Directors receiving Grants under Section 6, the
     "Grantees") from among the Participants and determine the number of shares
     of Company Stock subject to a particular Grant in such manner as the
     Committee determines; provided, however, that Non-Employee Directors shall
     only receive Grants pursuant to Section 6.  Nothing contained in this Plan
     shall be construed to (i) limit the right of the Company to grant options
     otherwise in connection with the acquisition, by purchase, lease, merger,
     consolidation or otherwise, of the business or assets of any corporation,
     firm or association, including options granted to employees thereof who
     become employees of the Company, or for other proper corporate purpose, or
     (ii) limit the right of the Company to grant stock options or make other
     awards outside of this Plan.

               5.   Granting of Options
                    -------------------

               (a) Number of Shares.  The Committee shall grant to each Grantee
     who is an employee or Key Advisor a number of stock options as the
     Committee shall determine.

               (b) Type of Option and Price.

               (i) The Committee may grant options qualifying as incentive stock
          options ("Incentive Stock Options") within the meaning of Section 422
          of the Code and/or other stock options ("Nonqualified Stock Options")
          or any combination of Incentive Stock Options and Nonqualified Stock
          Options (hereinafter referred to collectively as "Stock Options"), all
          in accordance with the terms and conditions set forth herein.

                                       3
<PAGE>
 
               (ii) The purchase price of Company Stock subject to an Incentive
          Stock Option or a Nonqualified Stock Option shall be the fair market
          value of a share of such Stock on the date such Stock Option is
          granted. Notwithstanding the foregoing, with respect to a Stock Option
          other than an Incentive Stock Option, the price at which Company Stock
          may be purchased may be equal to either (i) the fair market value of
          Company Stock as of a date subsequent to the date of grant as
          specified by the Committee in the Grant Letter or (ii) the average of
          such fair market value over a period of time as specified by the
          Committee in the Grant Letter, but only when the price so established
          would not result in the disallowance of the Company's expense
          deduction pursuant to Section 162(m) of the Code.

               (iii)    The "fair market value" of Company Stock shall be the
          closing price of a share of Company Stock on the New York Stock
          Exchange; provided, however, that if shares of Company Stock shall not
          be listed on the New York Stock Exchange, then the fair market value
          will be the closing price of a share of Company Stock on the principal
          stock exchange on which such shares are listed for trading, or if no
          sale takes place on such day on any such exchange, the average of the
          closing bid and asked prices on such day as officially quoted on any
          such stock exchange or if the Company Stock is not admitted to trading
          on any stock exchange the fair market price shall be the last sale
          reported on the NASDAQ National Market System published in the Wall
          Street Journal or, if no such sale is so reported, the average of the
          reported closing bid and asked prices on such day in the over-the-
          counter market, as furnished by the National Association of Security
          Dealers Automated System, or, if such price at the time is not
          available from such system, as furnished by any similar system then
          engaged in the business of reporting such prices and selected by the
          Company or, if there is no such system, as furnished by any member of
          the National Association of Security Dealers, selected by the Company.

               (c) Exercise Period.  The Committee shall determine the option
     exercise period of each Stock Option.  The exercise period shall not exceed
     ten years from the

                                       4
<PAGE>
 
     date of grant.  Notwithstanding any determinations by the Committee
     regarding the exercise period of any Stock Option, all outstanding Stock
     Options shall become immediately exercisable upon a Change in Control of
     the Company (as defined herein).

               (d) Vesting of Options.  The vesting period for Stock Options
     shall commence on the date of grant and shall end on the third anniversary
     thereof, with one-third of the shares of Company Stock subject to each
     Grant becoming purchasable on each anniversary date of the grant, on a
     cumulative basis (except as otherwise provided herein or in the Grant
     Letter or as otherwise determined by the Committee).  Notwithstanding any
     determinations by the Committee regarding the vesting period of any Stock
     Option, all outstanding Stock Options shall become immediately exercisable
     upon a Change in Control of the Company (as defined herein).

               (e) Manner of Exercise.  A Grantee may exercise a Stock Option by
     delivering a notice of exercise to the Committee with accompanying payment
     of the option price.  Such notice may instruct the Company to deliver
     shares of Company Stock due upon the exercise of the Stock Option to any
     registered broker or dealer designated by the Company ("Designated Broker")
     in lieu of delivery to the Grantee.  Such instructions must designate the
     account into which the shares are to be deposited.  The Grantee may tender
     this notice of exercise, which has been properly executed by the Grantee,
     and the aforementioned delivery instructions to any Designated Broker.

               (f) Termination of Employment, Disability or Death.

                    (1) In the event the Grantee during his lifetime ceases to 
     be an employee of the Company or Key Advisor for any reason other than
     death, any Stock Option which is otherwise exercisable by the Grantee shall
     terminate unless exercised within six months and one day of the date on
     which he ceases to be an employee or Key Advisor (or within such other
     period of time as may be specified in the Grant Letter), but in any event
     no later than the date of expiration of the option exercise period;
     provided, however, that in the case of a Grantee who is disabled within the
     meaning of Section 22(e)(3) of the Code, such period shall be one year
     rather than six months and one day (except as the Committee may otherwise
     provide in the Grant Letter) and that in the case of Incentive Stock
     Options, such period shall be 90 days rather than six months.

                    (2) In the event of the death of the Grantee while he is an
     employee or Key Advisor of the Company or within not more than three months
     of the date on which he ceases to be an employee or Key Advisor (or within
     such other period of time as may be specified in the Grant Letter), any
     Stock Option which was otherwise exercisable by the Grantee at the date of
     death may be exercised by his personal representative at any time prior to
     the expiration of one year from the date of death, but in any event no
     later than the date of expiration of the option exercise period.

                                       5
<PAGE>
 
               (g) Satisfaction of Option Price.  The Grantee shall pay the
     option price in cash or by delivering shares of Company Stock already owned
     by the Grantee for the period necessary to avoid a charge to the Company's
     earnings for financial reporting purposes and having a fair market value on
     the date of exercise equal to the option price or with a combination of
     cash and shares.  The Grantee shall pay the option price and the amount of
     withholding tax due, if any, at the time of exercise.  Shares of Company
     Stock shall not be issued or transferred upon exercise of a Stock Option
     until the option price is fully paid.

               (h) Limits on Incentive Stock Options.  Each Grant of an
     Incentive Stock Option shall provide that the aggregate fair market value
     of the Company Stock on the date of the Grant with respect to which
     Incentive Stock Options are exercisable for the first time by a Grantee
     during any calendar year under the Plan or any other stock option plan of
     the Company shall not exceed $100,000.  An Incentive Stock Option shall not
     be granted to any Participant who, at the time of grant, owns stock
     possessing more than 10 percent of the total combined voting power of all
     classes of stock of the Company or parent of the Company, unless the option
     price per share is not less than 110% of the fair market value of Company
     Stock on the date of grant and the option exercise period is not more than
     five years from the date of grant.

               6.   Stock Option Grants to Non-Employee Directors
                    ---------------------------------------------

               (a) Number of Shares.  Each individual who becomes a Non-Employee
     Director after the effective date of this Plan as set forth in Section 18
     shall receive a grant of a Non-qualified Stock Option to purchase 20,000
     shares of Company Stock as of the date of the first meeting of shareholders
     at which he or she is first elected to the Board of Directors or the first
     meeting of shareholders after he or she becomes a director (whether or not
     he or she is a candidate for election).

               (b) Option Price and Exercise Period.  The purchase price of
     Company Stock subject to such grants shall be the fair market value of a
     share of such stock as of the date such Stock Option is granted.  "Fair
     Market Value" shall be determined pursuant to Section 5(b).  Each Stock
     Option granted pursuant to this Section shall have an exercise period of
     ten years from the date of grant.

               (c) Vesting of Options.  The vesting period for such Stock
     Options shall commence on the date of grant and shall end on the fifth
     anniversary thereof, with 20% of the shares of Company Stock subject to
     each grant becoming exercisable on each anniversary date of the grant, on a
     cumulative basis.  Notwithstanding the foregoing, all outstanding Stock
     Options granted pursuant to this Section shall become immediately
     exercisable upon a Change in Control of the Company (as defined herein).

               (d) Manner of Exercise and Satisfaction of Option Price.  A Non-
     Employee Director may exercise and satisfy the option price of Stock
     Options granted pursuant to this Section in accordance with the provisions
     of Section 5(e) and (g) respectively.

                                       6
<PAGE>
 
               (e) Termination of Relationship With the Company, Disability or
     Death.

               (1) In the event a Non-Employee Director during his lifetime
          ceases to serve as a Non-Employee Director for any reason other than
          on account of becoming an employee of the Company or death, any Stock
          Option granted pursuant to this Section which is otherwise exercisable
          by the Non-Employee Director shall terminate unless exercised within
          six months of the date on which he ceases to serve as a Non-Employee
          Director, but in any event no later than the date of expiration of the
          option exercise period; provided, however, that in the case of a Non-
          Employee Director who is disabled within the meaning of Section
          105(d)(4) of the Code, such period shall be one year rather than six
          months.

               (2) In the event of the death of the Non-Employee Director while
          he is serving as a Non-Employee Director or within not more than three
          months of the date on which he ceases to be a Non-Employee Director,
          any Stock Option granted pursuant to this Section which was otherwise
          exercisable by the Non-Employee Director at the date of death may be
          exercised by his personal representative at any time prior to the
          expiration of one year from the date of death, but in any event no
          later than the date of expiration of the option exercise period.

               7.   Restricted Stock Grants

               The Committee may issue or transfer shares of Company Stock to a
     Participant under a grant (a "Restricted Stock Grant") pursuant to an
     incentive or long range compensation plan or program approved by the
     Committee and adopted by the Board of Directors of the Company.  Key
     Advisors shall not be eligible to receive Restricted Stock Grants.  The
     following provisions are applicable to Restricted Stock Grants:

               (a) General Requirements.  Shares of Company Stock issued
     pursuant to Restricted Stock Grants will be issued for no consideration.
     Subject to any other restrictions by the Committee as provided pursuant to
     this Section, restrictions on the transfer of shares of Company Stock set
     forth in Section 7(d) shall lapse as to up to one-third of the shares
     covered by a Restricted Stock Grant on each anniversary of the date of the
     grant or such other date as the Committee may approve until the
     restrictions have lapsed on 100% of the shares; provided, however, that
     upon a Change in Control of the Company (as defined herein), all
     restrictions on the transfer of the shares which have not, prior to such
     date, been forfeited shall immediately lapse.  The period of years during
     which the Restricted Stock Grant will remain subject to restrictions will
     be designated in the Grant Letter as the "Restriction Period."

               (b) Number of Shares.  The Committee shall grant to each Grantee
     a number of shares of Company Stock pursuant to a Restricted Stock Grant in
     such manner as the Committee determines.

                                       7
<PAGE>
 
               (c) Requirement of Employment.  If the Grantee's employment
     terminates during a period designated in the Grant Letter as the
     Restriction Period, the Restricted Stock Grant terminates as to all shares
     covered by the Grant as to which restrictions on transfer have not lapsed,
     and those shares of Company Stock must be immediately returned to the
     Company. The Committee may, however, provide for complete or partial
     exceptions to this requirement as it deems equitable.

               (d) Restrictions on Transfer and Legend on Stock Certificate.
     During the Restriction Period, a Grantee may not sell, assign, transfer,
     pledge, or otherwise dispose of the shares of Company Stock to which such
     Restriction Period applies except to a Successor Grantee under Section 9.
     Each certificate for a share issued or transferred under a Restricted Stock
     Grant shall contain a legend giving appropriate notice of the restrictions
     in the Grant. The Grantee shall be entitled to have the legend removed from
     the stock certificate or certificates covering any of the shares subject to
     restrictions when all restrictions on such shares have lapsed.

               (e) Unless the Committee determines otherwise, during the
     Restriction Period, the Grantee shall have the right to vote shares subject
     to the Restricted Stock Grant and to receive any regular cash dividends
     paid on such shares.

               (f) Lapse of Restrictions.  All restrictions imposed under the
     Restricted Stock Grant shall lapse upon the expiration of the applicable
     Restriction Period; provided, however, that upon a Change in Control of the
     Company (as defined herein), all restrictions on the transfer of the shares
     which have not, prior to such date, been forfeited shall immediately lapse.
     In addition, the Committee may determine as to any or all Restricted Stock
     Grants, that all the restrictions shall lapse, without regard to any
     Restriction Period, under such circumstances as it deems equitable.

               8.   Stock Appreciation Rights
                    -------------------------

               (a) The Committee may grant stock appreciation rights ("SARs") to
     any Grantee in tandem with any Stock Option, for all or a portion of the
     applicable Stock Option, either at the time the Stock Option is granted or
     at any time thereafter while the Stock Option remains outstanding;
     provided, however, that in the case of an Incentive Stock Option, such
     rights may be granted only at the time of the grant of such Stock Option.
     The exercise price of each SAR shall be equal to (i) the exercise price or
     option price of the related Stock Option or (ii) the fair market value of a
     share of Company Stock as of the date of grant of such SAR, but only in
     such circumstances where the SAR is granted subsequent to the date of grant
     of the related Stock Option and an exercise price established in accordance
     with clause (i) above would result in the disallowance of the Company's
     expense deduction pursuant to Section 162(m) of the Code and related
     Treasury regulations.

               (b) The number of SARs granted to a Grantee which shall be
     exercisable during any given period of time shall not exceed the number of
     shares of Company

                                       8
<PAGE>
 
     Stock which the Grantee may purchase upon the exercise of the related Stock
     Option or Stock Options during such period of time.  Upon the exercise of a
     Stock Option, the SARs relating to the Company Stock covered by such Stock
     Option shall terminate.  Upon the exercise of SARs, the related Stock
     Option shall terminate to the extent of an equal number of shares of
     Company Stock.

               (c) Upon a Grantee's exercise of some or all of his SARs, the
     Grantee shall receive in settlement of such SARs an amount equal to the
     value of the stock appreciation for the number of SARs exercised, payable
     in cash, Company Stock or a combination thereof.  Subject to adjustments
     required pursuant to Subsection (a)(ii), the stock appreciation for an SAR
     is the difference between the option price specified for the related Stock
     Option and the fair market value of the underlying Company  Stock on the
     date of exercise of such SAR.

               (d) At the time of such exercise, the Grantee shall have the
     right to elect the portion of the amount to be received that shall consist
     of cash and the portion that shall consist of Common Stock, which for
     purposes of calculating the number of shares of Company Stock to be
     received, shall be valued at their fair market value on the date of
     exercise of such SARs.  The Committee shall have the right to disapprove a
     Grantee's election to receive cash in full or partial settlement of the
     SARs exercised, and to require that shares of Company Stock be delivered in
     lieu of cash.  If shares of Company Stock are to be received upon exercise
     of an SAR, cash shall be delivered in lieu of any fractional share.

               (e) An SAR is exercisable only during the period when the Stock
     Option to which it is related is also exercisable.
 
               9.   Transferability of Options and Grants
                    -------------------------------------

               (a) Only a Participant or his or her authorized legal
     representative may exercise rights under a Grant.  Such persons may not
     transfer those rights except by will or by the laws of descent and
     distribution or, if permitted in any specific case by the Committee in
     their sole discretion, pursuant to a qualified domestic relations order as
     defined under the Code or Title I of ERISA or the regulations thereunder.
     When a Participant dies, the personal representative or other person
     entitled to succeed to the rights of the Participant ("Successor Grantee")
     may exercise such rights.  A Successor Grantee must furnish proof
     satisfactory to the Company of his or her right to receive the Grant under
     the Participant's will or under the applicable laws of descent and
     distribution.

               (b)  Notwithstanding the foregoing, the Committee may provide, in
     a Grant Letter, that a Grantee may transfer Nonqualified Stock Options to
     family members or other persons or entities according to such terms as the
     Committee may determine; provided that the Grantee receives no
     consideration for the transfer of an Option and the transferred Option
     shall continue to be subject to the same terms and conditions as were
     applicable to the Option immediately before the transfer.

                                       9
<PAGE>
 
               10.  Change in Control of the Company
                    --------------------------------

               As used herein, a "Change in Control" shall be deemed to have
     occurred if Rhone-Poulenc S.A. and its Affiliates (as used herein, the term
     "Affiliates" shall be deemed to include any corporation, joint venture, or
     other business enterprise, whether incorporated or unincorporated, which
     Rhone-Poulenc S.A. directly, or indirectly through one or more
     intermediaries, controls or is controlled by, or is under common control
     with) cease to be the beneficial owners (as such term is used in Sections
     13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) of
     securities of the Company representing more than fifty percent (50%) of the
     combined voting power of the Company's then outstanding securities.

               11.  Amendment and Termination of the Plan
                    -------------------------------------

               (a) Amendment.  The Board of Directors of the Company, by written
     resolution, may amend or terminate the Plan at any time; provided, however,
     that any amendment that materially increases the benefits accruing to
     Participants under the Plan, increases the aggregate number (or individual
     limit for any single Grantee) of shares of Company Stock that may be issued
     or transferred under the Plan (other than by operation of Section 3(b)), or
     materially modifies the requirements as to eligibility for participation in
     the Plan, shall be subject to approval by the shareholders of the Company
     if required by applicable law, and provided, further, that the Board of
     Directors shall not amend the Plan without shareholder approval if such
     approval is required by Section 162(m) of the Code, or if such amendment
     would cause the Plan or the Grant or exercise of an Incentive Stock Option
     under the Plan to fail to comply with the requirements of Section 422 of
     the Code including, without limitation, a reduction of the option price set
     forth in Section 5(b) or an extension of the period during which an
     Incentive Stock Option may be exercised as set forth in Section 5(c).

               (b) Termination of Plan.  The Plan shall terminate on the tenth
     anniversary of its effective date unless terminated earlier by the Board of
     Directors of the Company or unless extended by the Board with the approval
     of the shareholders.

               (c) Termination and Amendment of Outstanding Grants.  A
     termination or amendment of the Plan that occurs after a Grant is made
     shall not result in the termination or amendment of the Grant unless the
     Grantee consents or unless the Committee acts under Section 19(b).  The
     termination of the Plan shall not impair the power and authority of the
     Committee with respect to an outstanding Grant.  Whether or not the Plan
     has terminated, an outstanding Grant may be terminated or amended under
     Section 19(b) or may be amended by agreement of the Company and the Grantee
     consistent with the Plan.

               12.  Funding of the Plan
                    -------------------

               This Plan shall be unfunded.  The Company shall not be required
     to establish any special or separate fund or to make any other segregation
     of assets to assure the

                                       10
<PAGE>
 
     payment of any Grants under this Plan.  In no event shall interest be paid
     or accrued on any Grant, including unpaid installments of Grants.

               13.  Rights of Participants
                    ----------------------

               Nothing in this Plan shall entitle any Participant or other
     person to any claim or right to be granted an award under this Plan.
     Neither this Plan nor any action taken hereunder shall be construed as
     giving any Participant any rights to be retained by or in the employ of the
     Company.

               14.  Withholding of Taxes
                    --------------------

               The Company shall have the right to deduct from all Grants paid
     in cash, or from other wages paid to the employee of the Company, any
     federal, state or local taxes required by law to be withheld with respect
     to such cash awards and, in the case of Grants paid in Company Stock, the
     Participant or other person receiving such shares shall be required to pay
     to the Company the amount of any such taxes which the Company is required
     to withhold with respect to such Grants or the Company shall have the right
     to deduct from other wages paid to the employee by the Company the amount
     of any withholding due with respect to such Grants.

               15.  Agreements with Participants
                    ----------------------------

               Each Grant made under this Plan shall be evidenced by a Grant
     Letter containing such terms and conditions as the Committee shall approve.

               16.  Requirements for Issuance of Shares
                    -----------------------------------

               No Company Stock shall be issued or transferred upon payment of
     any Grant hereunder unless and until all legal requirements applicable to
     the issuance or transfer of such Company Stock have been complied with to
     the satisfaction of the Committee.  The Committee shall have the right to
     condition any Restricted Stock Grant or Stock Option made to any
     Participant hereunder on such Participant's undertaking in writing to
     comply with such restrictions on his subsequent disposition of such shares
     of Company Stock as the Committee shall deem necessary or advisable as a
     result of any applicable law, regulation or official interpretation
     thereof, and certificates representing such shares may be legended to
     reflect any such restrictions.

               17.  Headings
                    --------

               Section headings are for reference only.  In the event of a
     conflict between a title and the content of a Section, the content of the
     Section shall control.

                                       11
<PAGE>
 
               18.  Effective Date and Designation of the Board
                    -------------------------------------------

               Subject to the approval of the Company's shareholders, this Plan
     shall be effective as of May 1, 1995.

               19.  Miscellaneous
                    -------------
 
               (a) Substitute Grants.  The Committee may make a Grant to an
     employee of another corporation who becomes a Participant by reason of a
     corporate merger, consolidation, acquisition of stock or property,
     reorganization or liquidation involving the Company or any of its
     subsidiaries in substitution for a stock option or restricted stock grant
     granted by such corporation ("Substituted Stock Incentives").  The terms
     and conditions of the substitute Grant may vary from the terms and
     conditions required by the Plan and from those of the Substituted Stock
     Incentives.  The Committee shall prescribe the provisions of the substitute
     Grants.

               (b) Compliance with Law.  The Plan, the exercise of Grants and
     the obligations of the Company to issue or transfer shares of Company Stock
     under Grants shall be subject to all applicable laws and to approvals by an
     governmental or regulatory agency as may be required.  With respect to
     persons subject to Section 16 of the Exchange Act, it is the intent of the
     Company that the Plan and all transactions under the Plan comply with all
     applicable provisions of Rule 16b-3 or its successors under the Exchange
     Act.  The Committee may revoke any Grant if it is contrary to law or modify
     a Grant to bring it into compliance with any valid and mandatory government
     regulation.  The Committee may also adopt rules regarding the withholding
     of taxes on payments to Grantees.  The Committee may, in its sole
     discretion, agree to limit its authority under this Section.

               (c) Ownership of Stock.  A Grantee or Successor Grantee shall
     have no rights as a shareholder with respect to any shares of Company Stock
     covered by a Grant until the shares are issued or transferred to the
     Grantee or Successor Grantee on the stock transfer records of the Company;
     provided, however, that such individuals shall have the right to vote
     shares of Company Stock subject to a Restricted Stock Grant and to the
     payment of cash dividends on such shares during the Restriction Period.

                                       12


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