DEXTER CORP
SC 13D/A, 1999-12-14
PAINTS, VARNISHES, LACQUERS, ENAMELS & ALLIED PRODS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                                (Amendment No. 4)

                         ------------------------------

                               DEXTER CORPORATION
                                (Name of Issuer)

COMMON STOCK, $1.00 PAR VALUE PER SHARE                              252165105
   (Title of class of securities)                                 (CUSIP number)

                            RICHARD A. WEINBERG, ESQ.
                        C/O ISP MANAGEMENT COMPANY, INC.
                                 1361 ALPS ROAD
                             WAYNE, NEW JERSEY 07470
                                 (973) 628-3000
            (Name, address and telephone number of person authorized
                     to receive notices and communications)

                                 WITH A COPY TO:

                             STEPHEN E. JACOBS, ESQ.
                           WEIL, GOTSHAL & MANGES LLP
                                767 FIFTH AVENUE
                          NEW YORK, NEW YORK 10153-0119
                                 (212) 310-8000

                                DECEMBER 14, 1999
             (Date of event which requires filing of this statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-(g), check the
following box. [ ]

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss. 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purposes of Section 18 of the Securities Exchange Act of
1934 (the "Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act. (However, see the
Notes.)

                         (Continued on following pages)

                               (Page 1 of 7 Pages)

================================================================================


NY2:\856139\03\$CLN03!.DOC\54104.0016
<PAGE>

<TABLE>
<CAPTION>
- -----------------------------------------------------------              --------------------------------------------------------
CUSIP No. 252165105                                             13D                                           Page 2 of 7 Pages
- -----------------------------------------------------------              --------------------------------------------------------

- ----------------------    -------------------------------------------------------------------------------------------------------
<S>                       <C>
          1               NAME OF REPORTING PERSON                                ISP OPCO HOLDINGS INC.
                          S.S. OR I.R.S. IDENTIFICATION NO.
                          OF ABOVE PERSON
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          2               CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:                                    (a) [ ]
                                                                                                               (b) [X]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          3               SEC USE ONLY
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          4               SOURCE OF FUNDS:                                                  OO
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          5               CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
                          REQUIRED PURSUANT TO ITEM 2(d) OR 2(e):                                                     [ ]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          6               CITIZENSHIP OR PLACE OF ORGANIZATION:                                              Delaware
- ----------------------    ------------------------------------------------------------------------ ------------------------------

      NUMBER OF                   7               SOLE VOTING POWER:                                                  0
        SHARES
                          -------------------     ------------------------------------------------ ------------------------------
     BENEFICIALLY                 8               SHARED VOTING POWER:                                        2,299,200
       OWNED BY
                          -------------------     ------------------------------------------------ ------------------------------
         EACH                     9               SOLE DISPOSITIVE POWER:                                             0
      REPORTING
                          -------------------     ------------------------------------------------ ------------------------------
     PERSON WITH                  10              SHARED DISPOSITIVE POWER:                                   2,299,200

- ----------------------    ------------------------------------------------------------------------ ------------------------------
         11               AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING PERSON:
                                                                                                              2,299,200
- ----------------------    ------------------------------------------------------------------------ ------------------------------

         12               CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:                        [ ]

- ----------------------    ------------------------------------------------------------------------ ------------------------------

         13               PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):                                           9.98%
- ----------------------    ------------------------------------------------------------------------ ------------------------------
         14               TYPE OF REPORTING PERSON:                               CO
- ----------------------    ------------------------------------------------------------------------ ------------------------------

</TABLE>

<PAGE>

<TABLE>
<CAPTION>
- -----------------------------------------------------------              --------------------------------------------------------
CUSIP No. 252165105                                             13D                                           Page 3 of 7 Pages
- -----------------------------------------------------------              --------------------------------------------------------

- ----------------------    -------------------------------------------------------------------------------------------------------
<S>                       <C>
          1               NAME OF REPORTING PERSON                                ISP INVESTMENTS INC.
                          S.S. OR I.R.S. IDENTIFICATION NO.
                          OF ABOVE PERSON
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          2               CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:                                    (a) [ ]
                                                                                                               (b) [X]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          3               SEC USE ONLY
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          4               SOURCE OF FUNDS:                                                  WC, OO
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          5               CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
                          REQUIRED PURSUANT TO ITEM 2(d) OR 2(e):                                                     [ ]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          6               CITIZENSHIP OR PLACE OF ORGANIZATION:                                              Delaware
- ----------------------    ------------------------------------------------------------------------ ------------------------------

      NUMBER OF                   7               SOLE VOTING POWER:                                          2,299,200
        SHARES
                          -------------------     ------------------------------------------------ ------------------------------
     BENEFICIALLY                 8               SHARED VOTING POWER:                                                0
       OWNED BY
                          -------------------     ------------------------------------------------ ------------------------------
         EACH                     9               SOLE DISPOSITIVE POWER:                                     2,299,200
      REPORTING
                          -------------------     ------------------------------------------------ ------------------------------
     PERSON WITH                  10              SHARED DISPOSITIVE POWER:                                           0

- ----------------------    ------------------------------------------------------------------------ ------------------------------
         11               AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING PERSON:
                                                                                                              2,299,200
- ----------------------    ------------------------------------------------------------------------ ------------------------------

         12               CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:                        [ ]

- ----------------------    ------------------------------------------------------------------------ ------------------------------

         13               PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):                                           9.98%
- ----------------------    ------------------------------------------------------------------------ ------------------------------
         14               TYPE OF REPORTING PERSON:                               CO
- ----------------------    ------------------------------------------------------------------------ ------------------------------

</TABLE>


<PAGE>

<TABLE>
<CAPTION>
- -----------------------------------------------------------              --------------------------------------------------------
CUSIP No. 252165105                                             13D                                           Page 4 of 7 Pages
- -----------------------------------------------------------              --------------------------------------------------------

- ----------------------    -------------------------------------------------------------------------------------------------------
<S>                       <C>
          1               NAME OF REPORTING PERSON                                INTERNATIONAL SPECIALTY
                          S.S. OR I.R.S. IDENTIFICATION NO.                       PRODUCTS INC.
                          OF ABOVE PERSON
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          2               CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:                                    (a) [ ]
                                                                                                               (b) [X]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          3               SEC USE ONLY
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          4               SOURCE OF FUNDS:                                                  OO
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          5               CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
                          REQUIRED PURSUANT TO ITEM 2(d) OR 2(e):                                                     [ ]
- ----------------------    ------------------------------------------------------------------------------------ ------------------
          6               CITIZENSHIP OR PLACE OF ORGANIZATION:                                              Delaware
- ----------------------    ------------------------------------------------------------------------ ------------------------------

      NUMBER OF                   7               SOLE VOTING POWER:                                                  0
        SHARES
                          -------------------     ------------------------------------------------ ------------------------------
     BENEFICIALLY                 8               SHARED VOTING POWER:                                        2,299,200
       OWNED BY
                          -------------------     ------------------------------------------------ ------------------------------
         EACH                     9               SOLE DISPOSITIVE POWER:                                             0
      REPORTING
                          -------------------     ------------------------------------------------ ------------------------------
     PERSON WITH                  10              SHARED DISPOSITIVE POWER:                                   2,299,200

- ----------------------    ------------------------------------------------------------------------ ------------------------------
         11               AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING PERSON:
                                                                                                              2,299,200
- ----------------------    ------------------------------------------------------------------------ ------------------------------

         12               CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:                        [ ]

- ----------------------    ------------------------------------------------------------------------ ------------------------------

         13               PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):                                           9.98%
- ----------------------    ------------------------------------------------------------------------ ------------------------------
         14               TYPE OF REPORTING PERSON:                               CO
- ----------------------    ------------------------------------------------------------------------ ------------------------------

</TABLE>
<PAGE>
                     This Amendment No. 4 ("Amendment No. 4") amends the
Statement on Schedule 13D (the "Schedule 13D") filed on April 22, 1999, as
amended by Amendment No. 1 filed on August 11, 1999, Amendment No. 2 filed on
September 8, 1999, and Amendment No. 3 filed on September 27, 1999, by and on
behalf of ISP Opco Holdings Inc. ("ISP Opco"), ISP Investments Inc. ("ISP
Investments") and International Specialty Products Inc. ("ISP" and, together
with ISP Opco and ISP Investments, the "Reporting Persons") with respect to
their ownership of common stock, par value $1.00 per share (the "Common Stock"),
of Dexter Corporation (the "Company"). Capitalized terms used herein and not
defined herein have the meanings ascribed thereto in the Schedule 13D.

ITEM 4.              PURPOSE OF THE TRANSACTION

                     On December 14, 1999, Samuel J. Heyman, Chairman of the
Board of ISP, sent the following letter to K. Grahame Walker, Chairman of the
Board and Chief Executive Officer of the Company, with respect to ISP's interest
in the Company and its majority-owned subsidiary, Life Technologies, Inc.:

           Dear Grahame:

                     It was nice meeting with you, John Thompson, and Bruce
           Beatt on December 3rd.

                     As Kumar Shah and I indicated to you, our interest is in
           the realization of shareholder values for all Dexter Corporation and
           Life Technology shareholders. In this connection, based on our
           analysis, we believe that Life Technologies, with its higher growth
           and higher margins, can better fulfill its potential as an
           independent entity, or in combination with another similarly
           strategically situated company, rather than in combination with
           Dexter Corporation. We also believe that it will be in the best
           interests of both companies and their respective shareholders if
           Dexter Corporation and Life Technologies were separate corporate
           entities.

                     The overriding reason for this conclusion stems primarily
           from the fact that there are practically no overlaps and the
           companies add no value to each other. Specifically, Dexter
           Corporation's R&D, product development and manufacturing technology
           have no interface, and lack any synergy, with Life Technologies.
           Furthermore, we believe that Dexter Corporation has restrained Life
           Technologies' growth by limiting Life Technologies' R&D expenditures,
           new product development and new product introductions. Marketing,
           sales and distribution likewise provide no crossover benefits for the
           two companies. In addition to the operational issues, we note that
           Dexter Corporation management has little or no experience in the life
           science field.

                     From a financial perspective, as an independent company,
           Life Technologies would have much greater access to the capital
           markets, without the constraints of Dexter Corporation's financial
           profile. Life Technologies, as a pure play on which analysts and
           shareholders can more clearly and easily focus, would attract a high
           level of Wall Street coverage, providing the opportunity to achieve
           P/E multiples similar to those achieved by others, who serve the same
           market. This would enable Life Technologies to consummate attractive
           stock acquisitions and mergers in the emerging life science field,
           which you acknowledge has been constrained under your ownership.

                     Finally, as an independent company, or as part of a high
           technology company serving the biotechnology industry, Life
           Technologies would be in a position to provide greater incentives for
           its executives. Through making available stock options with a


                                       5
<PAGE>
           significant upside potential to all key-operating employees, Life
           Technologies would be providing a better opportunity to attract,
           hire, and most importantly, retain quality personnel to insure and
           maximize its continued profitable growth.

                     As a substantial shareholder of both Dexter Corporation and
           Life Technologies, it is our position that, for the foregoing
           reasons, there is value to be realized in the separate corporate
           existence of these two entities. At our meeting, while I was pleased
           that you appeared to share our view that there are few, if any,
           synergies between Dexter Corporation and Life Technologies, I had
           hoped that you would be more receptive to our proposal. However,
           since that time, by your lack of response and your recent comments to
           security analysts, it appears that you disagree with our approach to
           maximizing shareholder value nor do you appear to have in mind any
           alternative strategy for accomplishing the same goal.

                     As long term shareholders of both Dexter and Life
           Technologies, we think we have been more than patient. Our Board has
           therefore decided to propose acquiring all of the Dexter Corporation
           common stock not owned by International Specialty Products Inc. and
           its affiliates for a price of $45.00 per share subject to the
           execution of a mutually acceptable merger agreement. Such a price
           represents a 38% premium over where Dexter Corporation closed last
           night (32-9/16), and is higher than the stock has ever traded. In
           addition, if you would provide us additional information on Dexter
           Corporation and Life Technologies that justifies an increased price
           we would be willing to pay more. We would be willing to enter into a
           confidentiality agreement in connection therewith (but not any such
           agreement that would limit our rights as shareholders).

                     We and our advisors are available to move quickly to
           consummate this transaction. Grahame, please let me know how you and
           your Board would like to proceed.


                                           Sincerely,

                                           /s/ Samuel J. Heyman




             [The remainder of this page intentionally left blank.]



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<PAGE>
                                   SIGNATURES

                     After reasonable inquiry and to the best of their knowledge
and belief, the undersigned certify that the information set forth in this
Statement is true, complete and correct.



Dated:   December 14, 1999

                                     ISP OPCO HOLDINGS INC.
                                     ISP INVESTMENTS INC.
                                     INTERNATIONAL SPECIALTY PRODUCTS INC.

                                     By: /s/ Susan B. Yoss
                                         -------------------------------------
                                         Susan B. Yoss
                                         Senior Vice President and Treasurer










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