BIO RESPONSE INC
NT 10-K, 1999-04-01
BLANK CHECKS
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             SECURITIES AND EXCHANGE COMMISSION
                    WASHINGTON, DC 20549
                              
                         FORM 12b-25
                              
                Commission File Number 0-9201
                              
               NOTIFICATION OF LATE FILING of
                          Form 10-K
                 For Period Ending 12/31/98

Nothing in this form shall be construed to imply that the
Commission has verified any information contained herein.

If the notification relates to a portion of the filing check
above, identify the item(s) to which the notification
relates: n/a

                           PART I
                   REGISTRANT INFORMATION

Full name of registrant: Bio-Response, Inc.

Address of principal executive office:  1612 North Osceola
Avenue, Clearwater, FL 33755

                           PART II
                   Rule 12-b25 (b) AND (c)

If the subject report could not be filed without
unreasonable effort or expense and the registrant seeks
relief pursuant to Rule 12b-25(b), the following should be
completed. (Check box if appropriate.)

X    (a) the reasons described in reasonable detail in Part
III of this form could not be eliminated without
unreasonable effort or expense; (b) the subject annual
report, semi-annual report, transition report on Form 10-K,
20-F, 11-K or Form N-SAR, or portion thereof will be filed
on or before the 15th calendar day following the prescribed
due date; or the subject quarterly report or transition
report on Form 10-Q, or portion thereof will be filed on or
before the fifth calendar date following the prescribed due
date; and (c) the accountant's statement or other exhibit
required by Rule 12b-25(c) has been attached if applicable.

                          PART III
                          NARRATIVE
                              
State below in reasonable detail the reasons why Form 10-K,
11-K, 20-F, 10-Q, N-SAR or the transition report portion
thereof could not be filed within the prescribed time
period. (Attach extra sheets if needed.)

     Over the 5 days leading up to March 31, 1999, the
Corporation experienced severe technological problems with
its systems which are maintained by independent third
parties. The Corporation has no control over such technical
problems that prevented data and facsimile transmissions
between the Corporation and its professionals.
     
                           PART IV
                      OTHER INFORMATION

(1) Name and telephone number of person to contact in regard
to this notification: Sally A. Fonner, 727-443-3434.

(2) Have all other periodic reports required under Section
13 or 15(d) of the Securities Exchange Act of 1934 or
Section 30 of the Investment Company Act of 1940 during the
preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed?
If the answer is no, identify reports. YES.

(3) It is anticipated that any significant change in results
of operations from the corresponding period for the last
fiscal year will be reflected by the earnings statements to
be included in the subject report or portion thereof? NO.


BIO-RESPONSE, INC., has caused this notification to be
signed on its behalf by the undersigned thereunto duly
authorized.

Date:     3/31/99
By:  /s/ Sally A. Fonner
     Sally A. Fonner, President, Chairman


                          ATTENTION
Intentional misstatements or omissions of fact constitute
Federal criminal violations (see 18 USC 1001).









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