BP AMOCO PLC
SC 13D, 1999-09-23
PETROLEUM REFINING
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<PAGE>

               SECURITIES AND EXCHANGE COMMISSION
                      Washington, DC 20549


                          SCHEDULE 13D
                         (Rule 13d-101)
            Under the Securities Exchange Act of 1934
 INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a)
        AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a)

                           Vysis, Inc.
- -----------------------------------------------------------------
                        (Name of Issuer)

             Common Stock, par value $.01 per share
- -----------------------------------------------------------------
                 (Title of Class of Securities)

                            928961101
- -----------------------------------------------------------------
                         (CUSIP Number)

                        Daniel B. Pinkert
                      BP Amoco Corporation
                     200 East Randolph Drive
                         Mail Code 2106
                     Chicago, Illinois 60601
                         (312) 856-3025
- -----------------------------------------------------------------
    (Name, Address and Telephone Number of Person Authorized
             to Receive Notices and Communications)

                        December 31, 1998
- -----------------------------------------------------------------
     (Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule
13G  to  report  the  acquisition which is the  subject  of  this
Schedule  13D, and is filing this schedule because of  Rule  13d-
1(b)(3) or (4), check the following box [ ].

NOTE:   Six  copies  of this statement, including  all  exhibits,
should be filed with the Commission.  See Rule 13d-1(a) for other
parties to whom copies are to be sent.

<PAGE>
- --------------------
CUSIP NO. 928961101
- --------------------
- -----------------------------------------------------------------
1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)
     BP Amoco p.l.c.; I.R.S. Identification No.: None
- -----------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                 (a)  [X ]

                                                 (b)  [  ]
- -----------------------------------------------------------------
3.   SEC USE ONLY

- -----------------------------------------------------------------
4.   SOURCE OF FUNDS
     OO
- -----------------------------------------------------------------
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
     REQUIRED PURSUANT TO ITEMS 2(D) OR 2(E)

                                                       [  ]
- -----------------------------------------------------------------
6.   CITIZENSHIP OR PLACE OF ORGANIZATION
     England and Wales
- -----------------------------------------------------------------
                  7.   SOLE VOTING POWER
   NUMBER  OF          6,662,682  SHARES  -   AMOCO TECHNOLOGY COMPANY
   SHARES        -----------------------------------
   BENEFICIALLY   8.   SHARED VOTING POWER
   OWNED BY            0
   EACH          ----------------------------------------
   REPORTING      9.   SOLE DISPOSITIVE POWER
   PERSON              6,662,682 SHARES -  AMOCO TECHNOLOGY COMPANY
   WITH          ----------------------------------------
                 10.  SHARED DISPOSITIVE POWER
                      0
- -----------------------------------------------------------------
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     6,662,682 SHARES
- -----------------------------------------------------------------
12.  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
     CERTAIN SHARES

                                              [  ]
- -----------------------------------------------------------------
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     68.0%
- -----------------------------------------------------------------
14.  TYPE OF REPORTING PERSON
     CO
- -----------------------------------------------------------------
              *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
                          SCHEDULE 13D
                 RELATING TO THE COMMON STOCK OF
                           VYSIS, INC.

Item 1.   Security and Issuer.

This  Statement relates to the common stock, par value  $.01  per
share, of Vysis, Inc. ("Vysis").  The principal executive offices
of  Vysis  are  located at 3100 Woodcreek Drive,  Downers  Grove,
Illinois 60515-5424.

Item 2.   Identity and Background.

This  Statement  is  being filed by BP Amoco p.l.c.,  an  English
public  limited  company  ("BP Amoco").  The  principal  business
address  of  BP  Amoco  is Britannic House,  1  Finsbury  Circus,
London, EC2M 7BA, England. BP Amoco is a company operating in the
petroleum and petrochemical industries.

(a)-(c);  (f)   The  name,  business address,  present  principal
occupation or employment, and the name and principal business  of
any corporation or other organization in which such employment is
conducted of each of the directors and executive officers  of  BP
Amoco  is  set  forth in Schedule I hereto. Except  as  otherwise
indicated in Schedule I, each person listed in Schedule I  hereto
is a citizen of the United Kingdom.

(d)-(e)  During the last five years, neither BP Amoco nor, to the
knowledge  of BP Amoco, any of the persons listed on  Schedule  I
hereto,   (i)  has  been  convicted  in  a  criminal   proceeding
(excluding  traffic violations or similar misdemeanors)  or  (ii)
has  been  a  party  to  a  civil proceeding  of  a  judicial  or
administrative body of competent jurisdiction and as a result  of
such  proceeding was or is subject to a judgment, decree or final
order enjoining future violations of, or prohibiting or mandating
activities  subject  to,  federal or state  securities  laws,  or
finding any violation with respect to such laws.

As  described in Item 5 below, BP Amoco may be deemed to be  part
of  a  group  with  its  subsidiaries, Amoco  Technology  Company
("ATC")   and   BP  Amoco  Corporation  (formerly   named   Amoco
Corporation).   ATC  and  Amoco Corporation  previously  filed  a
Statement on Schedule 13D dated February 19, 1998 reporting their
beneficial ownership of shares of Vysis common stock.

Item 3.   Source and Amount of Funds or Other Consideration.

As  previously  reported in the Statement on Schedule  13D  dated
February 19, 1998 filed by ATC and Amoco Corporation with respect
to  Vysis common stock, on February 10, 1998, Vysis completed  an
initial  public offering of 3,000,000 shares of its common  stock
at  a  price  to the public of $12.00 per share.   Prior  to  the
initial  public offering, ATC was the owner of substantially  all
of  the  equity interest in Vysis.  At the time of the  offering,
ATC  agreed to convert $8.1 million of debt owed to it  by  Vysis
into  675,000  shares  of common stock (at  the  public  offering
price).

Effective  December 31, 1998, Amoco Corporation merged  with  The
British Petroleum Company p.l.c. As a result of the merger, Amoco
Corporation   and   its   subsidiary  ATC   became   wholly-owned
subsidiaries of The British Petroleum Company p.l.c.  The British
Petroleum Company p.l.c. changed its name to BP Amoco p.l.c., and
Amoco Corporation changed its name to BP Amoco Corporation.

Item 4.   Purpose of the Transaction.

ATC  continues  to  own  6,662,682  shares of Vysis common stock,
constituting 68.0% of the outstanding  common  stock  immediately
after the  initial public offering.  ATC has no present intention
to take specific  actions listed in Items  4(a)-(j)  of  Schedule
13-D.   However,  as  controlling  stockholder,   BP  Amoco   may
independently  plan or propose such actions from  time-to-time in
the future,  and  may support  or  reject  management  plans  and
propositions relating  to such actions.

Item 5.   Interest in Securities of the Issuer.

(a)   Effective December 31, 1998, BP Amoco became  the  indirect
parent  of ATC, which is the owner of record of 6,662,682  shares
of Vysis common stock (the "Shares").  As a result, BP Amoco is a
beneficial owner of the Shares and may be deemed to be  a  member
of  a  group  with  ATC  and  BP Amoco Corporation.   The  Shares
constitute 68.0% of the outstanding Vysis common stock.

(b)  ATC has the sole power to vote and dispose of the Shares.

(c)  None.

(d)   ATC  has  all  of  the rights of a holder  of  the  Shares,
including  the right to receive dividends from and  the  proceeds
from the sale of the Shares.

(e)  Not applicable


Item 6.   Contracts,     Arrangements,     Understandings      or
          Relationships with Respect to Securities of the Issuer.

Vysis  and ATC entered into a Registration Rights Agreement dated
February 5, 1998 pursuant to which Vysis granted ATC registration
rights  under  the Securities Act with respect to the  shares  of
Vysis  common stock owned by ATC.  Under the Registration  Rights
Agreement,  ATC  may sell securities under one  effective  demand
registration  per  calendar  year  and  the  right  may  only  be
exercised with respect to specified minimum amounts of shares  of
Common Stock.

Item 7.   Material to be filed as Exhibits.

Registration   Rights  Agreement  between  ATC  and  Vysis  dated
February 5, 1998 (incorporated by  reference to  the Statement on
Schedule 13D dated February 19, 1998 filed on  February  20, 1998
by ATC and Amoco Corporation with respect to Vysis common stock).

<PAGE>
                            SIGNATURE

     After reasonable inquiry and to the best of my knowledge and
belief,  I  certify  that  the  information  set  forth  in  this
Statement is true, complete and correct.

Dated:    September 23, 1999
                                   BP  AMOCO p.l.c.



                                   By:  /s/ Paula J. Clayton
                                   -----------------------------
                                   Name: P. J. Clayton
                                   Title: Deputy Company Secretary

<PAGE>
                           SCHEDULE I

               DIRECTORS AND EXECUTIVE OFFICERS OF
                         BP AMOCO P.L.C.

      The  name,  citizenship,  present principal  occupation  or
employment, and the name of any corporation or other organization
in  which  such employment is conducted, of each of the directors
and  executive  officers  as  of  July 9, 1999 of BP Amoco p.l.c.
("BP Amoco")  is set forth below. Except as set forth below, each
of the directors and executive  officers  is  a  citizen  of  the
United Kingdom. The business address of each director and officer
is  BP  Amoco p.l.c., Britannic  House, 1 Finsbury Circus, London
EC2M  7BA, England. Unless otherwise indicated,  each  occupation
set  forth  opposite  an  executive  officer's  name   refers  to
employment with BP Amoco.

Name                     Present Principal Occupation or Employment
- ----                     ------------------------------------------

Directors                (Executive Officer positions noted, where applicable)
- ---------
P.D. Sutherland          Non-executive Co-Chairman, Chairman of
(Ireland)                Goldman Sachs International

H. L. Fuller             Executive Co-Chairman
(United States)

Sir Ian Prosser          Non-executive Deputy Chairman, Chairman
                         and Chief Executive of Bass PLC

Sir John Browne          Executive Director and Group Chief Executive

Dr. J. G. S. Buchanan    Executive Director and Chief Financial Officer
(British and New Zealand)

R. F. Chase              Executive Director and Deputy Group Chief Executive

Dr. C. S. Gibson-Smith   Executive Director, Regions and Policies

R. L. Olver              Executive Director, Exploration and Production

B. K. Sanderson          Executive Director, Chemicals

R. S. Block              Non-executive  Director,  retired
(United States)          Executive Vice President and
                         Chief Insurance Officer, The Equitable

J. H. Bryan              Non-executive Director, Chairman and Chief Executive
(United States)          Officer of Sara Lee Corporation

E. B. Davis, Jr.         Non-executive Director, President and Chief Executive
(United States)          Officer of Alliant Energy

R. J. Ferris             Non-executive Director, retired Co-chairman of
(United States)          Doubletree Corporation

C. F. Knight             Non-executive Director, Chairman and Chief Executive
(United States)          Officer of Emerson Electric

F. A. Maljers            Non-executive Director, Chairman of the Supervisory
(Netherlands)            Board of the Amsterdam Concertgebouw N.V.

Dr. W. E. Massey         Non-executive Director, President of Morehouse College
(United States)

H. M. P. Miles           Non-executive  Director,  Chairman  of Johnson Matthey

Sir Robin Nicholson      Non-executive Director, retired Chairman of
                         Pilkington Optronics

M. H. Wilson            Non-executive Director, Vice Chairman and Director of
(Canada)                 RBC Dominion Securities, Inc.

R. P. Wilson            Non-executive Director, Chairman of Rio Tinto plc

The Lord Wright of      Non-executive Director, Chairman of the Royal
Richmond                Institute of International Affairs

Executive Officers
- ------------------
J. C. Hanratty           Company Secretary
(New Zealand)





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