<PAGE> PAGE 1
000 B000000 05/31/2000
000 C000000 0000316968
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 Y
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 T. ROWE PRICE PRIME RESERVE FUND, INC.
001 B000000 811-2603
001 C000000 4103452000
002 A000000 100 EAST PRATT STREET
002 B000000 BALTIMORE
002 C000000 MD
002 D010000 21202
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 Y
007 B000000 2
007 C010100 1
007 C020100 T. ROWE PRICE PRIME RESERVE SHARES
007 C030100 N
007 C010200 2
007 C020200 T. ROWE PRICE PRIME RESERVE PLUS SHARES
007 C030200 N
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
008 A00AA01 T. ROWE PRICE ASSOCIATES, INC.
008 B00AA01 A
008 C00AA01 801-856
008 D01AA01 BALTIMORE
008 D02AA01 MD
008 D03AA01 21202
011 A00AA01 T. ROWE PRICE INVESTMENT SERVICES, INC.
011 B00AA01 8-25130
011 C01AA01 BALTIMORE
011 C02AA01 MD
011 C03AA01 21202
012 A00AA01 T. ROWE PRICE SERVICES, INC.
012 B00AA01 84-1079
012 C01AA01 BALTIMORE
012 C02AA01 MD
<PAGE> PAGE 2
012 C03AA01 21202
013 A00AA01 PRICEWATERHOUSECOOPERS
013 B01AA01 BALTIMORE
013 B02AA01 MD
013 B03AA01 21202
014 A00AA01 T. ROWE PRICE INVESTMENT SERVICES, INC.
014 B00AA01 8-25130
015 A00AA01 STATE STREET BANK & TRUST COMPANY
015 B00AA01 C
015 C01AA01 BOSTON
015 C02AA01 MA
015 C03AA01 02101
015 E01AA01 X
018 00AA00 Y
019 A00AA00 Y
019 B00AA00 90
019 C00AA00 TROWEPRICE
020 C000001 0
020 C000002 0
020 C000003 0
020 C000004 0
020 C000005 0
020 C000006 0
020 C000007 0
020 C000008 0
020 C000009 0
020 C000010 0
021 000000 0
022 A000001 GOLDMAN SACHS & CO.
022 B000001 13-5108880
022 C000001 13260257
022 D000001 377678
022 A000002 CS FIRST BOSTON
022 B000002 13-5659485
022 C000002 7973465
022 D000002 260481
022 A000003 CHASE SECURITIES
022 B000003 13-3112953
022 C000003 5588545
022 D000003 516474
022 A000004 MORGAN (JP) SECURITIES INC
022 B000004 13-3224016
022 C000004 3131339
022 D000004 89683
022 A000005 MERRILL LYNCH PIERCE FENNER & SMITH
022 B000005 13-5674085
022 C000005 2584386
022 D000005 32359
022 A000006 MORGAN STANELY & CO INC
022 B000006 13-2655998
022 C000006 2334139
<PAGE> PAGE 3
022 D000006 49966
022 A000007 LEHMAN BROTHERS INC
022 B000007 13-2518466
022 C000007 1911303
022 D000007 145687
022 A000008 SALOMON SMITH BARNEY
022 B000008 11-2418191
022 C000008 1422247
022 D000008 62454
022 A000009 BANC ONE CAPITAL
022 B000009 31-1017233
022 C000009 926497
022 D000009 22934
022 A000010 BANK OF AMERICA
022 B000010 36-0947896
022 C000010 765179
022 D000010 24980
023 C000000 43070024
023 D000000 1624551
024 00AA00 N
025 A00AA01 MORGAN STANLEY
025 B00AA01 13-2655998
025 C00AA01 D
025 D00AA01 99781
025 A00AA02 BANC ONE
025 B00AA02 31-1017233
025 C00AA02 D
025 D00AA02 10012
025 A00AA03 GOLDMAN SACHS
025 B00AA03 13-5108880
025 C00AA03 D
025 D00AA03 50000
025 D00AA04 0
025 D00AA05 0
025 D00AA06 0
025 D00AA07 0
025 D00AA08 0
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 Y
027 000000 Y
029 00AA00 N
030 A00AA00 0
030 B00AA00 0.00
030 C00AA00 0.00
<PAGE> PAGE 4
031 A00AA00 0
031 B00AA00 0
032 00AA00 0
033 00AA00 0
034 00AA00 N
035 00AA00 0
036 B00AA00 0
037 00AA00 Y
038 00AA00 5
039 00AA00 N
040 00AA00 N
042 A00AA00 0
042 B00AA00 0
042 C00AA00 0
042 D00AA00 0
042 E00AA00 0
042 F00AA00 0
042 G00AA00 0
042 H00AA00 0
043 00AA00 0
044 00AA00 0
045 00AA00 Y
046 00AA00 N
047 00AA00 N
048 00AA00 0.000
048 A01AA00 0
048 A02AA00 0.000
048 B01AA00 0
048 B02AA00 0.000
048 C01AA00 0
048 C02AA00 0.000
048 D01AA00 0
048 D02AA00 0.000
048 E01AA00 0
048 E02AA00 0.000
048 F01AA00 0
048 F02AA00 0.000
048 G01AA00 0
048 G02AA00 0.000
048 H01AA00 0
048 H02AA00 0.000
048 I01AA00 0
048 I02AA00 0.000
048 J01AA00 0
048 J02AA00 0.000
048 K01AA00 0
048 K02AA00 0.000
049 00AA00 N
050 00AA00 N
051 00AA00 N
052 00AA00 Y
<PAGE> PAGE 5
053 A00AA00 N
054 A00AA00 Y
054 B00AA00 N
054 C00AA00 N
054 D00AA00 N
054 E00AA00 N
054 F00AA00 N
054 G00AA00 N
054 H00AA00 Y
054 I00AA00 N
054 J00AA00 Y
054 K00AA00 N
054 L00AA00 N
054 M00AA00 Y
054 N00AA00 N
054 O00AA00 Y
055 A00AA00 N
055 B00AA00 N
056 00AA00 Y
057 00AA00 N
058 A00AA00 N
059 00AA00 Y
060 A00AA00 Y
060 B00AA00 Y
061 00AA00 2500
062 A00AA00 Y
062 B00AA00 0.0
062 C00AA00 0.0
062 D00AA00 0.0
062 E00AA00 0.0
062 F00AA00 24.0
062 G00AA00 0.0
062 H00AA00 0.0
062 I00AA00 54.0
062 J00AA00 0.0
062 K00AA00 0.0
062 L00AA00 22.0
062 M00AA00 0.0
062 N00AA00 0.0
062 O00AA00 0.0
062 P00AA00 0.0
062 Q00AA00 0.0
062 R00AA00 0.0
063 A00AA00 43
063 B00AA00 0.0
064 A00AA00 N
066 A00AA00 N
067 00AA00 N
068 A00AA00 N
068 B00AA00 N
069 00AA00 N
<PAGE> PAGE 6
070 A01AA00 Y
070 A02AA00 N
070 B01AA00 N
070 B02AA00 N
070 C01AA00 N
070 C02AA00 N
070 D01AA00 N
070 D02AA00 N
070 E01AA00 N
070 E02AA00 N
070 F01AA00 N
070 F02AA00 N
070 G01AA00 N
070 G02AA00 N
070 H01AA00 N
070 H02AA00 N
070 I01AA00 N
070 I02AA00 N
070 J01AA00 Y
070 J02AA00 Y
070 K01AA00 Y
070 K02AA00 N
070 L01AA00 Y
070 L02AA00 N
070 M01AA00 N
070 M02AA00 N
070 N01AA00 Y
070 N02AA00 N
070 O01AA00 Y
070 O02AA00 N
070 P01AA00 Y
070 P02AA00 N
070 Q01AA00 N
070 Q02AA00 N
070 R01AA00 N
070 R02AA00 N
071 A00AA00 0
071 B00AA00 0
071 C00AA00 0
071 D00AA00 0
072 A00AA00 12
072 B00AA00 308721
072 C00AA00 0
072 D00AA00 0
072 E00AA00 0
072 F00AA00 19882
072 G00AA00 0
072 H00AA00 0
072 I00AA00 12253
072 J00AA00 238
072 K00AA00 224
<PAGE> PAGE 7
072 L00AA00 444
072 M00AA00 24
072 N00AA00 75
072 O00AA00 0
072 P00AA00 0
072 Q00AA00 101
072 R00AA00 14
072 S00AA00 11
072 T00AA00 0
072 U00AA00 0
072 V00AA00 0
072 W00AA00 91
072 X00AA00 33357
072 Y00AA00 0
072 Z00AA00 275364
072AA00AA00 0
072BB00AA00 83
072CC01AA00 0
072CC02AA00 0
072DD01AA00 273628
072DD02AA00 1736
072EE00AA00 0
073 A01AA00 0.0510
073 A02AA00 0.0490
073 B00AA00 0.0000
073 C00AA00 0.0000
074 A00AA00 0
074 B00AA00 0
074 C00AA00 5638582
074 D00AA00 0
074 E00AA00 0
074 F00AA00 0
074 G00AA00 0
074 H00AA00 0
074 I00AA00 0
074 J00AA00 0
074 K00AA00 0
074 L00AA00 68774
074 M00AA00 10682
074 N00AA00 5718038
074 O00AA00 26150
074 P00AA00 1164
074 Q00AA00 0
074 R01AA00 0
074 R02AA00 0
074 R03AA00 0
074 R04AA00 23899
074 S00AA00 0
074 T00AA00 5666825
074 U01AA00 5618313
074 U02AA00 48573
<PAGE> PAGE 8
074 V01AA00 1.00
074 V02AA00 1.00
074 W00AA00 0.9999
074 X00AA00 272163
074 Y00AA00 0
075 A00AA00 5391897
075 B00AA00 0
076 00AA00 0.00
077 A000000 Y
077 B000000 Y
078 000000 N
080 A00AA00 ICI MUTUAL INSURANCE COMPANY
080 C00AA00 75000
081 A00AA00 Y
081 B00AA00 125
082 A00AA00 N
082 B00AA00 0
083 A00AA00 N
083 B00AA00 0
084 A00AA00 N
084 B00AA00 0
085 A00AA00 Y
085 B00AA00 N
086 A01AA00 0
086 A02AA00 0
086 B01AA00 0
086 B02AA00 0
086 C01AA00 0
086 C02AA00 0
086 D01AA00 0
086 D02AA00 0
086 E01AA00 0
086 E02AA00 0
086 F01AA00 0
086 F02AA00 0
028 A010100 698429
028 A020100 25181
028 A030100 0
028 A040100 648575
028 B010100 902470
028 B020100 22523
028 B030100 0
028 B040100 851337
028 C010100 717896
028 C020100 22377
028 C030100 0
028 C040100 707647
028 D010100 888414
028 D020100 25918
028 D030100 0
028 D040100 880978
<PAGE> PAGE 9
028 E010100 665205
028 E020100 22486
028 E030100 0
028 E040100 798030
028 F010100 733096
028 F020100 26152
028 F030100 0
028 F040100 567195
028 G010100 4605510
028 G020100 144638
028 G030100 0
028 G040100 4453763
028 H000100 0
028 A010200 12008
028 A020200 158
028 A030200 0
028 A040200 12688
028 B010200 20578
028 B020200 147
028 B030200 0
028 B040200 14523
028 C010200 17999
028 C020200 171
028 C030200 0
028 C040200 12898
028 D010200 17531
028 D020200 213
028 D030200 0
028 D040200 16481
028 E010200 14596
028 E020200 189
028 E030200 0
028 E040200 15769
028 F010200 12438
028 F020200 217
028 F030200 0
028 F040200 9429
028 G010200 95150
028 G020200 1094
028 G030200 0
028 G040200 81787
028 H000200 0
SIGNATURE JAMES S. RIEPE
TITLE VICE PRESIDENT
