AMGEN INC
8-K/A, 1995-02-02
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                  SECURITIES AND EXCHANGE COMMISSION

                       WASHINGTON, D.C.  20549

                              FORM 8-K/A

            Amendment to Current Report Filed Pursuant to
      Section 13 or 15(d) of the Securities Exchange Act of 1934



November 18, 1994
- - - -----------------
Date of Report (Date of earliest event reported)



                              Amgen Inc.
- - - ----------------------------------------------------------------------
        (Exact name of registrant as specified in its charter)



     Delaware                   0-12477                95-3540776
- - - ----------------------------------------------------------------------
 (State or other              (Commission         (I.R.S. Employer
  jurisdiction                File Number)        Identification No.)
of incorporation)



1840 Dehavilland Drive, Thousand Oaks, California      91320-1789
- - - ----------------------------------------------------------------------
(Address of principal executive offices)                    (Zip Code)



Registrant's telephone number, including area code: (805) 447-1000
- - - ----------------------------------------------------------------------



- - - ----------------------------------------------------------------------
    (Former name or former address, if changed since last report.)
<PAGE>
Item 2.   ACQUISITION OR DISPOSITION OF ASSETS



     On November 18,  1994, Amgen  Inc. ("Amgen")  and Synergen,  Inc.
("Synergen") announced  that  they entered  into  a  definitive
agreement through which Amgen would acquire Synergen.  Pursuant to this
agreement,  Amgen's   wholly-owned   subsidiary,   Amgen   Acquisition
Subsidiary, Inc. ("Amgen  Acquisition Subsidiary"),  completed a  cash
tender offer (the "Tender Offer") to  purchase all of the  outstanding
shares of Synergen  common stock (including  the associated  preferred
stock purchase rights)  for $9.25  per share.   In  the Tender  Offer,
Amgen Acquisition Subsidiary acquired approximately 91 percent of  the
outstanding shares of common stock of Synergen.  Following  completion
of the  Tender Offer,  Amgen Acquisition  Subsidiary was  merged  into
Synergen (the  "Merger").   Pursuant  to  the Merger,  each  share  of
Synergen common stock (other than shares  owned by Amgen, Synergen  or
any  of  their  respective  subsidiaries)  that  remained  outstanding
following completion of the Tender Offer was converted into the  right
to receive $9.25 per share in cash.   As a result of the Tender  Offer
and   Merger   (hereinafter   collectively   referred   to   as    the
"Acquisition"), Synergen is  now a wholly-owned  subsidiary of  Amgen.
Funds from Amgen's  working capital were  used to  purchase shares  of
Synergen stock.   In  determining the  amount to  be offered  for  the
shares of Synergen  stock, Amgen considered,  among other things,  the
financial condition and results of operations of Synergen and detailed
financial  and  valuation  analyses  presented  to  Amgen  by  Amgen's
financial advisors.   It  is anticipated  that at  least some  of  the
assets constituting  plant,  equipment  and  other  physical  property
generally used  in Synergen's  business will  continue to  be used  by
Amgen for  such purposes  but  Amgen has  not  yet determined  how  it
intends to use all of such assets.  This  Form 8-K/A amends the Form 
8-K Current Report dated December 2, 1994.
                                
                                2
<PAGE>
Item 7.   FINANCIAL STATEMENTS AND EXHIBITS


     (a)  Financial statements of business acquired

                                                                Page
                                                               Number


Audited Consolidated Financial Statements of Synergen, Inc.
  and Subsidiaries

     Independent Auditors' Report................................F-1

     Consolidated Balance Sheet as of December 31, 1993..........F-2

     Consolidated Statement of Operations for the year
     ended December 31, 1993.....................................F-3

     Consolidated Statement of Stockholders' Equity for the
     year ended December 31, 1993................................F-4

     Consolidated Statement of Cash Flows for the year ended
     December 31, 1993...........................................F-5

     Notes to Consolidated Financial Statements...........F-6 - F-17

Unaudited Consolidated Financial Statements of Synergen, Inc.
  and Subsidiaries

     Consolidated Balance Sheet as of September 30, 1994........F-18

     Consolidated Statements of Operations for the nine
     months ended September 30, 1994 and 1993...................F-19

     Consolidated Statements of Cash Flows for the nine
     months ended September 30, 1994 and 1993...................F-20

     Notes to Unaudited Consolidated Financial
     Statements..........................................F-21 - F-22

                                3
<PAGE>
     (b)  Pro forma financial information

                                                                Page
                                                               Number

Introduction to Amgen Inc. Unaudited Pro Forma Condensed
  Combining Financial Statements ...............................F-23

Amgen Inc. Unaudited Pro Forma Condensed Combining Balance
  Sheet as of September 30, 1994 ...............................F-24

Amgen Inc. Unaudited Pro Forma Condensed Combining Statement
  of Operations for the year ended December 31, 1993 ....F-25 - F-26

Amgen Inc. Unaudited Pro Forma Condensed Combining Statement
  of Operations for the nine months ended September 30,
  1994 ..................................................F-27 - F-28

Notes to Amgen Inc. Unaudited Pro Forma Condensed Combining
  Financial Statements .........................................F-29


     (c)  Exhibits

Agreement and Plan of Merger among Amgen Inc., Amgen
  Acquisition Subsidiary, Inc. and Synergen, Inc. (1)

Independent Auditors' Consent...................................F-30


(1)  Filed as  an  exhibit  to  the  Form  8-K  Current  Report  dated
December 2, 1994 and incorporated by reference.


                                SIGNATURE


Pursuant to the requirements of the  Securities Exchange Act of 1934,
the registrant has  duly caused  this amendment to  be signed  on its
behalf by the undersigned thereunto duly authorized.


                                     Amgen Inc.
                                     (Registrant)



Date:     2/02/95                    By:/s/ Robert S. Attiyeh
- - - ------------------------             --------------------------------
                                     Robert S. Attiyeh
                                     Senior Vice President, 
                                     Finance and Corporate 
                                     Development, and Chief 
                                     Financial Officer

                                4
<PAGE>
                     INDEPENDENT AUDITORS' REPORT



To the Board of Directors and Stockholders of
Synergen, Inc.
Boulder, Colorado

  We have  audited  the accompanying  consolidated  balance sheet  of
Synergen, Inc.  and  subsidiaries as  of  December 31,  1993  and  the
related consolidated  statements of  operations, stockholders'  equity,
and cash flows  for the year then ended.  These financial  statements
are  the   responsibility   of   the  Company's   management.      Our
responsibility is to  express an opinion on these financial statements
based on our audit.

  We conducted  our  audit  in  accordance  with  generally  accepted
auditing standards.  Those standards require that we plan and  perform
the audit to obtain reasonable  assurance about whether the  financial
statements are  free  of material  misstatement.   An  audit  includes
examining, on  a  test  basis, evidence  supporting  the  amounts  and
disclosures in  the  financial statements.    An audit  also  includes
assessing the  accounting principles  used and  significant  estimates
made by  management,  as  well as  evaluating  the  overall  financial
statement  presentation.    We  believe  that  our  audit  provides  a
reasonable basis for our opinion.

  In our  opinion,  such  consolidated financial  statements  present
fairly, in all material respects, the financial position of  Synergen,
Inc. and subsidiaries as of December 31, 1993 and the results of their
operations and their cash flows for  the year ended December 31,  1993
in conformity with generally accepted accounting principles.




/s/ DELOITTE & TOUCHE LLP
Denver, Colorado
February 4, 1994

                               F-1
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
                      CONSOLIDATED BALANCE SHEET

                               ASSETS
                                                 December 31, 1993
  Current assets:                                -----------------
    Cash and cash equivalents                       $ 51,579,100
    Short-term investments                           104,637,200
    Accounts  receivable   (no   allowance  for
     doubtful accounts considered necessary)          14,561,000
    Receivable from Synergen Clinical Partners         6,200,000
    Accrued interest receivable                          779,200
    Prepaid expenses and other                         2,975,400
                                                    ------------
       Total current assets                          180,731,900

  Property and equipment, net                         86,856,100

  Other assets                                         8,469,700
                                                    ------------
       Total assets                                 $276,057,700
                                                    ============

                LIABILITIES AND STOCKHOLDERS' EQUITY
  Current liabilities-
    Accounts payable and accrued expenses           $ 11,229,100
                                                    ------------
       Total current liabilities                      11,229,100

  Industrial Development Revenue Bonds                 6,000,000
  Commitments and contingencies (Notes 7 and 11)
  Stockholders' equity:
    Preferred stock, $.01 par value; authorized
     10,000,000 shares; none issued                            -
    Common stock,  $.01  par  value; authorized
     120,000,000     shares;     issued     and
     outstanding, 25,666,186 shares                      256,700
    Additional paid-in capital, net                  408,369,500
    Deficit                                         (148,821,700)
    Deferred compensation  and  receivable  for
     warrants, net                                      (975,900)
                                                    ------------
       Total stockholders' equity                    258,828,600
                                                    ------------
       Total  liabilities   and   stockholders'
          equity                                    $276,057,700
                                                    ============

            See notes to consolidated financial statements

                               F-2
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
                 CONSOLIDATED STATEMENT OF OPERATIONS

                                                    Year Ended
                                                 December 31, 1993
                                                 -----------------
                                                                
  Revenues:
     Research and development                       $ 13,180,200
     Interest and other                               10,306,200
                                                    ------------
                                                      23,486,400

  Expenses:
    Research and development                          88,248,500
    General and administrative                        16,986,100
    Restructuring charge                               2,000,000
    Interest                                             447,500
                                                    ------------
                                                     107,682,100
  Loss before  cumulative effect  of change  in
    accounting principle                             (84,195,700)
                                                    ------------
  Cumulative effect  of  change  in  accounting
    principle                                         (2,417,800)
                                                    ------------
  Net loss                                          $(86,613,500)
                                                    ============

  Net loss per share:
    Loss before cumulative effect  of change in
     accounting principle                                 $(3.33)
    Cumulative effect  of change  in accounting
     principle                                              (.09)
                                                    ------------
  Net loss per share                                      $(3.42)
                                                    ============
  Weighted average common share outstanding           25,308,800

  Pro forma amounts assuming the new  method of
    accounting  for  patent  costs  is  applied
    retroactively:
  Net loss                                           (84,195,700)
  Net loss per share                                      $(3.33)

            See notes to consolidated financial statements

                               F-3
<PAGE>
                         SYNERGEN, INC. AND SUBSIDIARIES
                 CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY
                          YEAR ENDED DECEMBER 31, 1993
<TABLE>
<S>                           <C>         <C>         <C>           <C>            <C>
                                                                                      Deferred
                                                       Additional                   Compensation
                                   Common Stock         Paid-in                    and Receivable
                                Shares     Par Value    Capital        Deficit      for Warrants
                              ----------  ----------  ------------  -------------  --------------
Balance, January 1, 1993      25,083,146    $250,800  $405,244,900  $ (62,208,200)    $(1,566,000)
Exercise of stock options
 ($3.33 to $33.83 per share)
 net of treasury stock
 acquired                        468,319       4,700     2,230,900              -               -
Synergen Clinical Partners
 warrants exercised                4,001         100        62,600              -               -
Grants under Stock Bonus Plan     10,720         100       228,600              -               -
Contribution to Employee
 Stock Ownership Plan            100,000       1,000     1,036,500              -      (1,037,500)
Amortization of deferred
 compensation                          -           -             -              -       1,059,000
Amorization of receivable
 for warrants                          -           -             -              -         568,600
Foreign currency
 translation adjustment                -           -      (434,000)             -               -
Net loss                               -           -             -    (86,613,500)              -
                              ----------  ----------  ------------  -------------  --------------
Balance, December 31, 1993    25,666,186    $256,700  $408,369,500  $(148,821,700)    $  (975,900)
                              ==========  ==========  ============  ============== ==============                  
</TABLE>                 
     See notes to consolidated financial statements

                               F-4
<PAGE>
                  SYNERGEN, INC. AND SUBSIDIARIES
               CONSOLIDATED STATEMENT OF CASH FLOWS

                                                     Year Ended
                                                    December 31,
                                                       1993
                                                    ------------
  Cash flows from operating activities:
   Net loss                                         $(86,613,500)
   Adjustments to reconcile  net loss  to net  cash
    used in operating activities:
      Depreciation and amortization of assets          9,901,500
      Amortization  of  deferred  compensation  and
       receivable for warrants                         1,627,600
      Stock bonus awards                                 228,700
      Change in operating assets and liabilities:
      Accounts receivable                              4,009,300
      Accrued interest receivable                      1,590,400
      Prepaid expenses and other                        (120,600)
      Accounts payable and accrued expenses              384,600
      Unearned revenue                                  (779,900)
                                                    ------------
   Total adjustments                                  16,841,600
                                                    ------------
  Net cash used in operating activities              (69,771,900)

  Cash flows from investing activities:
   Capital expenditures                              (16,792,200)
   Net redemption of short-term investments          131,129,700
   Other, net                                          2,517,100
                                                    ------------
  Net cash provided by investing activities          116,854,600

  Cash flows provided by financing activities-
   Proceeds from issuance of common stock, net         1,864,300

  Net increase in cash and cash equivalents           48,947,000

  Cash and cash equivalents at beginning of period     2,632,100
                                                    ------------
  Cash and cash equivalents at end of period        $ 51,579,100
                                                    ============
  Supplemental disclosures:
   Interest paid                                    $    367,700
                                                    ============


             See notes to consolidated financial statements

                               F-5
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
              NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                     YEAR ENDED DECEMBER 31, 1993



1.  Summary of Significant Accounting Policies

Business

Synergen,  Inc.  is  a   biopharmaceutical  company  engaged  in   the
discovery,  development   and  manufacture   of  protein-based   human
pharmaceuticals.

Principles of Consolidation

The  accompanying  consolidated   financial  statements  include   the
accounts of Synergen, Inc. and its wholly owned subsidiaries, Synergen
Biologicals, Inc. (one percent general partner of Synergen Development
Partners  Limited--see  Note  3),  Synergen  Production   Corporation,
Synergen Development  Corporation  (one  percent  general  partner  of
Synergen Clinical  Partners, L.P.--see  Note 3)  and Synergen  Europe,
Inc. and  its subsidiary  Synergen B.V.  (collectively, the  Company).
All  material   intercompany   balances  have   been   eliminated   in
consolidation.

Cash and Cash Equivalents

Cash and cash equivalents are composed of immediately accessible funds
held in  bank  checking accounts,  money  market accounts  and  highly
liquid debt instruments with maturities not exceeding three months  at
purchase.

Short-term Investments

Short-term  investments  include   obligations  of  corporations   and
federal, state and local governments and agencies.  They are available
for sale to fund operations and  capital expenditures and are  carried
at the  lower of  aggregate cost  or market.   These  investments  are
classified as  non-current assets  to  the extent  they  collateralize
borrowings.

Property and Equipment

Property and equipment are recorded at cost.  Depreciation is provided
using the  straight-line  method  over the  assets'  estimated  useful
lives.  Buildings and improvements are depreciated over 10 to 20 years
and equipment is depreciated over 5 to 10 years.

Deferred Compensation and Receivable for Warrants

Receivable for warrants was composed of amounts receivable related  to
warrants issued in connection with the formation of Synergen  Clinical
Partners, L.P. in  February 1991 and  has been  amortized as  revenues
were earned from  Synergen Clinical Partners,  L.P.  As  of March  31,
1993, the  receivable  for warrants  was  fully amortized.    Deferred
compensation is related to both the Company's Employee Stock Ownership


                               F-6
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



Plan and  compensatory  stock grants  and  is amortized  over  vesting
periods ranging from one to five years.

Foreign Currency Translation

Pursuant to  Financial  Accounting  Standard  No.  52,  the  financial
position and results of the Company's European subsidiary are measured
using the  local currency  as the  functional currency.   The  balance
sheet has been translated at the  exchange rate in effect at  December
31, 1993,  while revenues  and expenses  have been  translated at  the
average exchange rate  on a monthly  basis.  The  aggregate effect  of
translation is being deferred as a component of stockholders'  equity.
At December  31,  1993, the  translation  effect is  $434,000  and  is
reported within additional paid in capital.

Research and Development

Revenues under research  and development contracts  are recognized  as
the related  research  and development  expenses  are incurred  or  as
development milestones  are reached  and  payment is  irrevocably  due
under the terms of the agreements.

Research and development costs are  expensed as incurred.   In-process
research and  development acquired  by issuance  of common  stock  and
warrants is expensed at acquisition at the fair value of the securities 
issued,  plus out-of-pocket and other costs.

Income Taxes

The Company adopted Statement of Financial Accounting Standards (SFAS)
No. 109, "Accounting  for Income  Taxes," effective  January 1,  1993.
This statement supersedes SFAS No. 96, "Accounting for Income  Taxes,"
that had been the Company's previous accounting method.  There was  no
cumulative effect of adopting SFAS No. 109 on the Company's  financial
statements (see Note 8).

Per Share Amounts

Per share  amounts are  computed on  the  weighted average  number  of
common shares outstanding.  The effect  of stock options and  warrants
is not included in loss per share because it is antidilutive.

                               F-7
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



2.  Change in Accounting Principle

In December 1993,  the Company changed  its method  of accounting  for
external patent  development  costs  from capitalizing  the  costs  to
expensing the costs  as incurred.   The Company  believes this  change
will conform more  closely to  predominant industry  practices.   This
resulted in  a  one-time charge  of  $2,417,800, $.09  per  share,  at
January 1, 1993, for the cumulative effect on prior years of  changing
this accounting principle.  Current year patent costs of $670,800 have
been included in general and administrative expenses.

3.  Research and Development Agreements

Synergen Clinical Partners, L.P.

On February  14,  1991,  Synergen Clinical  Partners,  L.P.  (Clinical
Partners)  completed  a  private  placement  of  limited   partnership
interests, which resulted in net proceeds of approximately $46,400,000
in cash and  notes receivable.   In connection with  the formation  of
Clinical  Partners,  the  Company  granted  to  Clinical  Partners  an
exclusive royalty-free  license and  right to  certain technology  for
human pharmaceutical use within the United States, Canada and Europe.

Under the terms of a development and marketing agreement with Clinical
Partners,  the  Company   is  performing   research  and   development
activities to obtain the approval from the FDA for the sale of ANTRIL,
the Company's  interleukin-1  receptor antagonist.    Revenues  earned
under the agreement  were $4,851,200 in  1993.   Included in  accounts
receivable at  December  31,  1993  are  $5,743,700  related  to  such
revenues.  All sponsored research and development revenue attributable
to this collaboration was  recognized in full by  March 31, 1993.   In
1991, the Company also received a non refundable fee of $2,500,000  in
connection with  the agreement.   This  fee was  recorded as  deferred
revenue and was being amortized  to research and development  revenues
over the period of partnership funding.  As of March 31, 1993, the fee
was fully amortized.  Under certain circumstances, the Company may  be
required to fund development of  Clinical Partners' products in  order
to retain  its option,  as described  below, to  purchase the  limited
partners' interests.  The Company is responsible for manufacturing and
marketing of Clinical Partners' products in the United States,  Canada
and Europe,  and is  required to  make payments  to Clinical  Partners
based on product  revenues.  Upon  the first marketing  approval of  a
Clinical Partners' product  by the FDA,  the Company  is obligated  to
make a  payment  of  between $8,400,000  and  $8,800,000  to  Clinical
Partners, payable  in  cash, common  stock  of the  Company,  or  some
combination thereof.

                               F-8
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



The Company has been granted an option to purchase all of the  limited
partners' interests  in  Clinical  Partners  exercisable  between  the
second and fourth  year after the  first commercial  sale of  Clinical
Partners' products depending upon  the size of  product revenues.   If
the Company  exercises  this  option, it  will  make  to  the  limited
partners an advance payment of between $34,200,000 and $36,000,000  in
cash, common stock of the Company,  or some combination thereof,  plus
additional payments based on sales  of Clinical Partners' products  in
the United States, Canada  and Europe for 11  years subsequent to  the
purchase of their interests.  In exchange for this option, the Company
issued warrants to the  limited partners to  purchase an aggregate  of
3,950,625 shares of its  common stock.   The warrants are  exercisable
through February 29, 1996,  at a price of  $15.69 per share, and  from
March 1, 1996  through February  28, 1998, at  a price  of $17.69  per
share.  In  addition, the Company  issued to the  sales agents of  the
private  placement  warrants  to  purchase  140,400  shares  that  are
exercisable through February 29, 1996 at a price of $16.31 per  share.
The fair value  of the  warrants was  recorded as  additional paid  in
capital, with  an  offsetting  receivable  recorded  in  stockholders'
equity.   The  receivable  was  amortized  as  a  charge  against  the
Company's research and  development revenues  from Clinical  Partners.
As of March 31, 1993, the receivable for warrants was fully amortized.
In January 1993, the Company  filed a registration statement  covering
shares issuable upon exercise of the warrants.

In order to fund organizational and offering costs, the Company loaned
Clinical Partners $6,200,000.  The loan  is with recourse to  Clinical
Partners and is secured by notes receivable from the limited  partners
to Clinical Partners aggregating approximately $11,883,100.  The  loan
bears interest at 9.75  percent, payable annually  in arrears, and  is
due in February 1994.

Syntex (U.S.A.) Inc.--Synergen Neuroscience Joint Venture

In  February  1990,  the  Company  entered  into  the  Syntex-Synergen
Neuroscience Joint Venture (Joint  Venture) with Syntex (U.S.A.)  Inc.
to  develop  neurotrophic  factors   for  the  treatment  of   certain
neurological diseases.   An affiliate  of Syntex  provided funding  of
$15,000,000 to  the  Joint Venture  for  the first  phase  of  product
development.  In connection with formation  of the Joint Venture,  the
Company granted Syntex warrants to purchase 1,125,000 shares of common
stock at an exercise price of  $12.67 per share.  The warrants,  which
expire in July 1997, became exercisable upon the affiliate's  election
to provide aggregate funding of $50,000,000 (including the $15,000,000
previously funded) to the Joint Venture.   The affiliate notified  the
Joint Venture in  January 1993 that  it had made  this election.   For
conducting research for the Joint Venture, the Company earned  revenue
of $8,188,000 in  1993 of which  $7,254,700 was  included in  accounts
receivable at December 31, 1993.

                               F-9
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



Synergen Development Partners Limited

In  November  1992,  the  Company  acquired  the  assets  of  Synergen
Development Partners Limited  (Development Partners)  in exchange  for
255,752 shares of common stock and warrants to purchase 209,252 shares
of common stock.   The warrants have an  exercise price of $67.77  and
will expire on June 30, 1997.  The acquisition has been accounted  for
principally as a  noncash charge to  operations totaling  $18,100,000,
equal to  the fair  value  of the  common  stock and  warrants  issued
($16,463,300), plus  the  out-of-pocket expenses  and  liabilities  of
Development Partners  assumed  or forgiven  by  the Company.    Assets
acquired consist principally of certain rights related to research and
development projects in process.  As a result of the acquisition,  the
Company owns  exclusive rights  to the  products previously  owned  by
Development Partners  and  has no  future  obligation to  the  limited
partners of Development Partners.

Selectide Corporation

In December 1992,  the Company entered  into a collaborative  research
agreement with Selectide Corporation to jointly develop small molecule
inhibitors of certain cytokines.   Under the  terms of the  agreement,
the Company has made a $3,000,000 equity investment in Selectide which
is included in other non-current assets.   The Company also agreed  to
provide Selectide  with research  funding, benchmark  payments on  the
achievement of certain milestones, and royalty payments on the sale of
products that  result from  the collaboration.    The amount  of  such
funding during 1993 and the estimated amount for 1994 are not material
and future obligations for research funding and benchmark payments are
contingent upon the occurrence  of certain events.   The agreement  is
terminable at the Company's discretion upon the occurrence of  certain
events.

                              F-10
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



4.  Property and Equipment

Property and equipment, at cost, consists of the following:

                                                  December 31, 1993
                                                 ------------------
Land and buildings                                    $ 46,814,600
Laboratory and manufacturing equipment                  50,556,700
Furniture and office equipment                          10,556,100
Construction work in progress                            1,483,700
                                                      ------------
                                                       109,411,100
Less accumulated depreciation                           22,555,000
                                                      ------------
Net property and equipment                            $ 86,856,100
                                                      ============

5.  Industrial Development Revenue Bonds Payable

In December  1984,  Boulder  County, Colorado,  issued  $6,000,000  of
Industrial Development Revenue  Bonds and loaned  the proceeds to  the
Company to  finance  acquisition and  improvement  of a  building  for
laboratory, production and  office use.   The bonds  are due  December
2009, subject to the bondholders' right to demand payment at par  each
December.   The bond  interest rate  is adjusted  annually to  a  rate
comparable to the  then-current yield  for similar  obligations.   The
stated interest rate was 3.5% at  December 31, 1993 and the  effective
rate was 4.9% for 1993.  The Company has a one-time opportunity on any
anniversary date  of  the  bonds to  fix  the  interest  rate  through
maturity.  The bonds are collateralized  by land and buildings with  a
net carrying amount of $24,419,100  and restricted investments with  a
carrying amount of $4,468,300  which are included  in other assets  at
December 31, 1993.   The Company  is required to  deposit $90,000  per
quarter (through December 31,  2000) in a sinking  fund.  The  Company
has a $6,000,000 letter of credit from a bank, which expires  December
1994, which can  be drawn to  the extent bonds  presented for  payment
cannot be remarketed.   No amounts have been  drawn on this letter  of
credit.  The  letter of credit  agreement contains covenants  relating
to, among other matters, minimum levels of net worth, working  capital
and  debt-to-equity  ratios,  restrictions  on  additional  debt   and
prohibits payment of common stock dividends.

                              F-11
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



6.  Stockholders' Equity

The Company has an incentive and non-qualified stock option plan under
which options  for up  to  2,500,000 shares  of  common stock  may  be
granted to selected  Company employees and  consultants.  The  Company
also had an incentive and non-qualified stock option plan that expired
in October 1993  under which  options for  up to  3,000,000 shares  of
common  stock  were   granted  to  selected   Company  employees   and
consultants.  The  exercise price for  options is  established by  the
compensation committee of the Board of Directors and incentive options
cannot be granted at a  price less than the  fair market value of  the
stock on the date of the grant.   All options granted under the  plans
will expire on dates up to ten years after the date of the grant.   In
May 1993,  the  compensation  committee  of  the  Board  of  Directors
approved the repricing of certain outstanding options held by  current
employees by granting  replacement options  to those  employees.   The
exercise price for these options is  $10.63, the fair market value  of
the stock  on  May  7,  1993,  and  the  vesting  period  on  all  the
replacement options  was  extended  from three  to  four  years.    At
December 31,  1993, options  to purchase  2,743,076 shares  at  prices
ranging from $3.33 to $52.75 per share, with a weighted average  price
of $9.95 per share, are outstanding under the plans, of which  options
for 1,187,621 shares  were exercisable; options  for 1,357,733  shares
had been exercised; and options for 1,344,652 shares were available to
be granted under the plans.

The Company has a stock option plan under which options to purchase up
to 150,000  shares of  common stock  may  be granted  to  non-employee
directors.   The plan  provides for  the grant  of stock  options  for
15,000 shares of the Company's common  stock to each new  non-employee
director upon election to the Board  and for annual grants of  options
for 3,000  shares  on  March  1 of  each  year  to  each  non-employee
director.  The  options expire eight  years after grant,  vest over  a
four-year period after grant and are  priced at the fair market  value
of the Company's common stock on the  date of grant.  At December  31,
1993, options for  39,000 shares  were outstanding  at prices  ranging
from $15.50 to $50.25  per share; of which  options for 20,250  shares
were exercisable; and options for 111,000 shares were available to  be
granted under the plan.

In 1988,  the Company  established an  Employee Stock  Ownership  Plan
(ESOP).   All Company  employees are  eligible to  participate in  the
ESOP.   The  Company may,  but  is not  required  to, make  an  annual
contribution to  the ESOP  of either  cash  or Company  common  stock.
Company contributions are allocated  to participants in proportion  to
compensation, with  certain limitations,  and  generally vest  over  a
five-year period.  In 1993, the Company contributed 100,000 shares  of
its common stock to the ESOP with a market value of $1,037,500.

                              F-12
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



The Company has a Stock Bonus Plan under which up to 150,000 shares of
common stock may be awarded to the Company's employees, directors, and
consultants.  At December 31, 1993,  95,819 shares of common stock had
been awarded  under the  plan, and  54,181 shares  were available  for
future awards.  Shares awarded generally vest immediately.

The Company  has a  stockholder  rights plan  that,  in the  event  of
certain acquisitions or attempts to acquire 20 percent or more of  the
Company's outstanding  stock by  an unrelated  third party  or  group,
would allow the remaining stockholders  to acquire Preferred Stock  or
additional common stock at one-half of the then market value.

No cash dividends have been paid or declared by the Company.

The Company  is authorized  to issue  10,000,000 shares  of  Preferred
Stock, none of which is currently outstanding.

7.  Commitments and Contingencies

The Company  has employment  contracts  with its  executive  officers.
Such contracts  provide for  severance pay  and automatic  renewal  in
certain instances and  have non-competition clauses.   Such  contracts
are cancelable  at  the Company's  option.   The  aggregate  severance
provisions are approximately $2,500,000.

Certain of the Company's technologies under development are subject to
royalty  agreements  which  provide  for  payments  of  royalties   to
universities and others in the  event commercial product sales  result
from use of the technologies.

In January 1990, the Company  reacquired rights to certain  technology
from CIBA-GEIGY in connection with termination of a joint  development
agreement between the parties.  The  Company has an obligation to  pay
to CIBA-GEIGY a portion of future revenues, if any, up to a maximum of
$4,700,000 derived from the technology.

8.  Income Taxes

Deferred income taxes  reflect the net  tax effects  of (a)  temporary
differences between the carrying amounts of assets and liabilities for
financial reporting  purposes  and the  amounts  used for  income  tax
purposes, and (b) operating loss and  tax credit carry forwards.   The
tax effects  of significant  items comprising  the Company's  deferred
taxes as of December 31, 1993 are as follows:

                              F-13
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



DEFERRED TAX ASSETS:

Operating loss carry forwards                         $ 49,080,900
Synergen Development Partners Limited
   acquisition costs                                     6,751,300
Tax credit carry forwards                                4,821,900
Other                                                    1,768,300
                                                      ------------
                                                        62,422,400
Valuation allowance                                    (62,422,400)
                                                      ------------
Net Deferred Tax Asset                                $          -
                                                      ============

There were no  material deferred tax  liabilities as  of December  31,
1993.

The total cumulative  effect of adopting  SFAS No. 109  at January  1,
1993 resulted in a deferred tax asset of $30,362,300.  This amount was
entirely reserved for by a valuation allowance.

The valuation allowance increased by $32,060,100 during the year ended
December 31, 1993.  This increase was a result of the increase in  the
deferred tax asset primarily  due to net  operating losses during  the
year.

At December  31,  1993,  the  Company  had,  for  federal  income  tax
purposes, net operating loss  carryforwards, research and  development
tax credit carryforwards, and  investment tax credit carryforwards  of
approximately $131,584,100,  $4,621,900  and  $200,000,  respectively,
which expire beginning in 1997 if not previously utilized.

9.  Restructuring Charge

In April 1993,  the Company implemented  a restructuring  in order  to
more fully utilize  Company resources and  focus the  projects of  the
organization.  As a result of  the restructuring, the Company  reduced
its work  force  by  approximately 12  percent,  or  approximately  85
employees.  The Company  incurred a one-time  charge of $2,000,000  in
the second quarter of 1993 due to the restructuring.

                              F-14
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



10.  Information about Financial Instruments

The carrying values of financial instrument assets (liabilities)  were
as follows:

                                                   December 31, 1993
                                                   -----------------
                                                   
Short-term investments                                $104,637,200
Accounts receivable and current note receivable         20,761,000
Investments and notes receivable included in
   other assets                                          4,468,300
Industrial Development Revenue Bonds                    (6,000,000)

The estimated fair value  of these financial instruments  approximated
the  carrying  value.    The  fair  value  of  short-term  and   other
investments is based primarily  on market quotes.   The fair value  of
receivables are considered to be  equivalent to carrying value,  based
on the nature  and terms  of such  amounts.   The face  amount of  the
industrial development  revenue bonds  is considered  to be  the  fair
value, as the interest  rate on the  bonds is reset  to a market  rate
each December.

The Company does not invest in financial instruments that create  off-
balance sheet  risk.    Both trade  receivables  and  interest-bearing
investments could be subject to concentration of credit risk.  Risk in
trade receivables is limited because they generally represent  amounts
due from sponsors which could lose rights in sponsored technology  due
to breach of  contract if they  failed to perform.   Interest  bearing
investments are  generally obligations  of the  federal government  or
investment grade  corporate or  municipal issuers.   At  December  31,
1993, non-federal  obligations were  limited  to money  market  mutual
funds  of  major  financial  institutions  and  to  other  investments
individually less than 5% of total assets.

11.  Litigation

Following a drop  in the  price of  Synergen's stock  on February  22,
1993, a number of class action complaints were filed against  Synergen
and certain of its officers and  directors in the U.S. District  Court
for the  District of  Colorado on  behalf of  various classes  of  the
Company's  investors.     The  complaints  were   consolidated  by   a
consolidated class action complaint which was filed on April 15, 1993.
In addition to Synergen, Kenneth J. Collins, executive vice  president
of  finance  and  administration,  is   named  as  defendant  in   the
consolidated  complaint,  together  with  Jon  S.  Saxe,  the   former
president and  chief  executive officer  and  a former  director,  and
Michael A. Catalano, the former  vice president of clinical  research.
The complaint alleges violations of federal securities laws and  state
law.  The Company believes the claims to be without merit and  intends
to vigorously contest them.

                              F-15
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993



On April 20, 1993, the United States Patent and Trademark Office (PTO)
declared  an  interference  between  Synergen's  U.S.  patent   number
4,997,929, issued March 5, 1991, and a patent application assigned  to
the Max Planck Institut fur Psychiatrie and Regeneron Pharmaceuticals,
Inc.   The interference  relates to  nucleic acid  molecules  encoding
human ciliary neurotrophic  factor (CNTF).   When  the PTO  determines
that there is a dispute as to who actually made an invention first, an
interference proceeding  can  be  declared,  and  the  applicants  are
required to prove who was the  first inventor.  In the United  States,
the general rule is that a patent ultimately is awarded to the  person
who is first to make an invention,  rather than the person who is  the
first to file  a patent application.   The Company  believes it has  a
reasonable patent position.

                              F-16
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
       NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (Continued)
                     YEAR ENDED DECEMBER 31, 1993

12.  Quarterly Financial Data (Unaudited)
<TABLE>
<S>                       <C>            <C>             <C>            <C>
                          First Quarter  Second Quarter  Third Quarter  Fourth Quarter
                          -------------  --------------  -------------  --------------
1993
- - - ----
Total revenues             $  9,399,700    $  3,638,100   $  4,703,000    $  5,745,600
Total expenses               30,221,900      29,393,000     23,095,800      24,971,400
Loss before cumulative
 effect of change in
 accounting principle       (20,822,200)    (25,754,900)   (18,392,800)    (19,225,800)
Loss per share before
 cumulative effect of
 change in accounting
 principle                        (0.83)          (1.02)         (0.73)          (0.75)
Net loss                    (23,240,000)    (25,754,900)   (18,392,800)    (19,225,800)
Net loss per share                (0.92)          (1.02)         (0.73)          (0.75)
</TABLE>
Quarterly financial data in 1993 has been restated to reflect the Company's
change in its method of accounting for external patent development costs
(see Note 2).

13.  Subsequent Events (unaudited)

On December 15, 1994, Synergen, the individual defendants, and the 
plantiff class entered into a Stipulation of Settlement concerning 
the class action.  Plaintiffs agreed to dismiss all claims, known and 
unknown, arising from the events described in their consolidated 
amended complaint.  In turn, defendants agreed to make a payment of 
$28 million in cash.  The Court gave preliminary approval of the 
settlement in an order dated December 15, 1994.  The Court's order 
provided for the issuance of notice to the members of the class 
and set a hearing for final approval of the settlement for 
March 7, 1995.

                              F-17
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
                      CONSOLIDATED BALANCE SHEET
                             (unaudited)

                                                  Sept. 30,
                                                     1994
                                                -------------
                                                           
                               ASSETS
       Current assets:
          Cash and cash equivalents             $  6,271,300
          Short-term investments                 104,979,200
          Accounts receivable                      9,655,400
          Accrued interest receivable                609,800
          Restricted short-term investments        8,253,200
          Prepaid expenses and other               1,735,700
                                                ------------
       Total current assets                      131,504,600

       Property and equipment, net                53,899,700

       Other assets:
          Restricted short-term investments          200,000
          Other                                    2,458,100
                                                ------------
       Total other assets                          2,658,100

       Total assets                             $188,062,400
                                                ============

                LIABILITIES AND STOCKHOLDERS' EQUITY
       Current Liabilities:
          Accounts   payable    and    accrued    
            expenses                              11,539,700
          Industrial Development Revenue Bonds     6,000,000
                                                ------------
       Total current liabilities                  17,539,700

       Stockholders' equity:
          Preferred stock, $.01 par value;
            authorized, 10,000,000 shares;
            none issued                                    -
          Common stock, $.01 par value;
            authorized, 120,000,000 shares;
            issued 25,921,880 shares                 259,200
          Additional paid-in capital, net        409,557,400
          Deficit                               (239,503,100)
          Deferred compensation, net                 209,200
                                                ------------
       Total stockholders' equity                170,522,700

       Total liabilities and stockholders'
          equity                                $188,062,400
                                                ============
       See notes to unaudited consolidated financial statements

                               F-18                              
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
                CONSOLIDATED STATEMENTS OF OPERATIONS
                             (unaudited)

                                          Nine Months   Nine Months
                                             Ended         Ended
                                         September 30, September 30,
                                             1994           1993
                                         ------------  ------------
REVENUES:
   Sponsored research and development    $ 10,781,200  $ 10,112,200
   Interest and other income                4,003,200     7,628,600
                                         ------------  ------------
TOTAL REVENUES                             14,784,400    17,740,800

EXPENSES:
   Research and development                53,192,100    66,602,200
   General and administrative              13,062,100    13,751,700
   Restructuring and asset impairment
     charge                                39,079,200     2,000,000
   Interest                                   132,400       356,800
                                         ------------  ------------
TOTAL EXPENSES                            105,465,800    82,710,700

Loss before cumulative effect of change
   in accounting principle                (90,681,400)  (64,969,900)

Cumulative effect of change in
   accounting principle                                  (2,417,800)   
                                         ------------  ------------
NET LOSS                                 $(90,681,400) $(67,387,700)
                                         ============  ============
LOSS PER SHARE:

Loss before cumulative effect of change
   in accounting principle                     $(3.52)       $(2.58)

Cumulative effect of change in
   accounting principle                             -         (0.09)
                                         ------------  ------------
NET LOSS PER SHARE                             $(3.52)       $(2.67)
                                         ============  ============
WEIGHTED AVERAGE COMMON SHARES
   OUTSTANDING                             25,746,800    25,163,900

       See notes to unaudited consolidated financial statements

                              F-19
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
                 CONSOLIDATED STATEMENTS OF CASH FLOWS
                             (unaudited)

                                        Nine Months      Nine Months
                                           Ended            Ended
                                       September 30,    September 30,
                                           1994            1993
                                     ---------------- ---------------
CASH FLOWS FROM OPERATING ACTIVITIES:  
Net loss                                $(90,681,400)   $(64,472,700)
Adjustments to reconcile net loss  to
 net cash used in operating activities:
   Depreciation and  amortization  of
    assets                                 8,006,400       6,944,300
   Amortization of receivable for
    warrants and deferred compensation       947,200       1,438,400
   Impairment of assets and
    restructuring                         33,991,400               -
 Change  in  operating assets and
   liabilities:
   Accounts receivable                     3,621,800       5,533,400
   Accrued interest receivable               169,400         874,200
   Prepaid expenses and other             (1,683,300)       (382,600)
   Accounts payable and accrued
    expenses                                 310,700      (1,524,900)
   Unearned revenue, net                           -        (779,900)
                                        ------------    ------------
Total adjustments                         45,363,600      12,102,900
                                        ------------    ------------
NET CASH USED IN OPERATING ACTIVITIES    (45,317,800)    (52,369,800)

CASH FLOWS FROM INVESTING ACTIVITIES:
Capital expenditures                      (1,266,700)    (15,561,400)
Net (purchase) redemption of short-
 term investments                         (4,165,100)    126,268,300
Payment received on note receivable
 from affiliate                            5,905,700               -
Other assets                              (1,254,100)       (465,700)
                                        ------------    ------------
NET CASH (USED IN) PROVIDED BY
INVESTING ACTIVITIES                        (780,200)    110,241,200

CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds  from  issuance  of   common
 stock and other, net                        790,200         580,500
                                        ------------    ------------
NET INCREASE (DECREASE) IN CASH AND
CASH EQUIVALENTS                         (45,307,800)     58,451,900


CASH AND CASH EQUIVALENTS AT 
BEGINNING OF PERIOD                       51,579,100       2,632,100
                                        ------------    ------------
CASH AND CASH EQUIVALENTS AT
END OF PERIOD                           $  6,271,300    $ 61,084,000
                                        ============    ============
       See notes unaudited to consolidated financial statements
                              
                              F-20
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
         NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS


1.  Accounting Policies

The consolidated balance sheet as of  September 30, 1994, the  related
consolidated statements of operations for the nine-month periods ended
September 30, 1994 and 1993, and  the consolidated statements of  cash
flows for the nine-month periods ended September 30, 1994 and 1993 are
unaudited, but  in  management's  opinion,  include  all  adjustments,
consisting only of  normal recurring adjustments  except as  otherwise
disclosed,  necessary  for  a  fair  presentation  of  such  financial
statements.  Interim results are not necessarily indicative of results
for a full year.

The financial  statements  should  be read  in  conjunction  with  the
consolidated financial  statements for  the  year ended  December  31,
1993.   The  accounting policies  used  in the  preparation  of  these
financial statements  are the  same as  those  used in  the  Company's
annual financial statements except as modified for appropriate interim
accounting policies.

Certain  reclassifications  have  been  made  to  the  Company's  1993
financial statements to  conform them  to 1994  classifications.   The
consolidated statements  of  operations  for  the  nine  months  ended
September 30, 1993, and consolidated statement  of cash flows for  the
nine-month period ending  September 30,  1993, have  been restated  to
reflect the Company's change in its method of accounting for  external
patent development costs.

Pursuant to  Financial  Accounting  Standard  No.  52,  the  financial
position  and  results   of  the  Company's   European  and   Japanese
subsidiaries are measured using the  local currency as the  functional
currency. The balance sheet has been  translated at the exchange  rate
in effect at September 30, 1994, while revenues and expenses have been
translated at  the  average exchange  rate  on a  monthly  basis.  The
aggregate effect of translation  is being deferred  as a component  of
stockholders' equity. At  September 30, 1994,  the translation  effect
was $139,800 and is reported within additional paid-in capital.

2.  Asset Impairment and Restructuring Charges

On July 15,  1994, Synergen learned  that an interim  analysis of  the
follow-up  Phase  III   clinical  trial   of  interleukin-1   receptor
antagonist (IL-1ra) showed a lack of efficacy for severe sepsis.  As a
result, certain assets were determined to be impaired and were written
down to estimated net realizable value. In August, Synergen  announced
a restructuring  which included  a termination  of 60  percent of  the
Company's workforce (approximately 375  employees) and elimination  of
some operations and development activities. Synergen recorded an asset
impairment charge of $5.8  million in the second  quarter of 1994  for
assets  used  primarily  for  the  production  of  IL-1ra  and   asset
impairment and restructuring  charges of  $33.3 million  in the  third
quarter of 1994 primarily related to the discontinuation of the sepsis
trial and the  Company's decision to  restructure its operations.  The
third quarter charges of $33.3 million were comprised of restructuring
charges of $7.3 million and asset  impairment charges of $26  million.
                              F-21
<PAGE>
                   SYNERGEN, INC. AND SUBSIDIARIES
          NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS

Of the third quarter asset  impairment charges, $22.6 million  related
to the  write-down  of  the LakeCentre  manufacturing  facility,  $1.9
million  was  due  to  other  assets  impaired  as  a  result  of  the
restructuring and the remaining $1.5 million was a charge against  the
Company's equity investment  in Selectide Corporation  based on  their
recent rights offering. The charge against the LakeCentre facility was
based on  a  preliminary independent appraisal  of the property  which
estimated the net realizable  value of the  property. The Company  may
take additional charges against the LakeCentre facility in the future.
                              
3.  Litigation

Following a drop  in the  price of  Synergen's stock  on February  22,
1993, a number of class action complaints were filed against  Synergen
and certain of its officers and  directors in the U.S. District  Court
for the  District of  Colorado on  behalf of  various classes  of  the
Company's  investors.     The  complaints  were   consolidated  by   a
consolidated class action complaint which was filed on April 15, 1993.
In addition to Synergen, Kenneth J. Collins, executive vice  president
of  finance  and  administration,  is   named  as  defendant  in   the
consolidated  complaint,  together  with  Jon  S.  Saxe,  the   former
president and chief executive officer and a former director, and
Michael A. Catalano, the former vice president of clinical research.
The complaint alleges violations of federal securities laws and state
law.  The Company believes the claims to be without merit and intends
to vigorously contest them.  

On April 20, 1993, the United States Patent and Trademark Office (PTO) 
declared an interference between Synergen's U.S. patent number 
4,997,929, issued March 5, 1991, and a patent application assigned 
to the Max Planck Institut fur Psychiatrie and Regeneron Pharmaceuticals, 
Inc.   The interference relates to nucleic acid  molecules encoding 
human ciliary neurotrophic factor (CNTF). When the PTO determines that 
there is a dispute as to who actually made an invention first, an 
interference proceeding can be declared, and the applicants are required 
to prove who was the first inventor.  In the United States, the general 
rule is that a patent ultimately is awarded to the person who is first 
to make an invention, rather than the person who is the first to file 
a patent application.  The Company believes it has a reasonable patent 
position.

4.  Subsequent Events

On December 15, 1994, Synergen, the individual defendants, and the 
plantiff class entered into a Stipulation of Settlement concerning 
the class action.  Plaintiffs agreed to dismiss all claims, known 
and unknown, arising from the events described in their consolidated 
amended complaint.  In turn, defendants agreed to make a payment of 
$28 million in cash.  The Court gave preliminary approval of the 
settlement in an order dated December 15, 1994.  The Court's order 
provided for the issuance of notice to the members of the class 
and set a hearing for final approval of the settlement for 
March 7, 1995.

                              F-22
<PAGE>
                   AMGEN INC. UNAUDITED PRO FORMA
              CONDENSED COMBINING FINANCIAL STATEMENTS


The following unaudited  pro forma condensed  combining balance sheet
as of  September  30,  1994 and  the  unaudited  pro  forma condensed
combining statements of operations of Amgen Inc. and its subsidiaries
for the  year  ended December  31,  1993 and  the  nine  months ended
September 30, 1994 have been prepared to illustrate the effect of the
Acquisition, which is  being accounted for  as a  purchase, as though
the Acquisition had occurred  on September 30, 1994  in the pro forma
balance sheet and as of January  1, 1993 and January  1, 1994, in the
pro forma statements  of operations.   The  pro forma  information is
based upon the historical financial statements  of Amgen Inc. and its
subsidiaries and Synergen,  Inc. and its  subsidiaries, giving effect
to the Acquisition  under the purchase  method of  accounting and the
assumptions and adjustments in  the accompanying Notes  to Amgen Inc.
Unauditied Pro Forma  Condensed Combining Financial  Statements.  The
pro forma adjustments and the assumptions on which they are based are
described in the accompanying Notes.  Certain items in the historical
financial statements of Synergen, Inc. and its subsidiaries have been
reclassified to  conform to  the  classifications of  the  Amgen Inc.
historical financial statements.

The Amgen  Inc.  unaudited pro  forma  condensed  combining financial
statements are presented for  illustrative purposes only  and are not
necessarily indicative  of  the  consolidated  financial  position or
consolidated results of operations of Amgen Inc. that would have been
reported had the Acquisition occurred on  the dates indicated, nor do
they represent a forecast  of the consolidated  financial position of
Amgen Inc.  at  any  future  date  or  the  consolidated  results  of
operations of  Amgen  Inc. at  any  future period.    Furthermore, no
effect has been given in the Amgen Inc. unaudited pro forma condensed
combining statements  of  operations  for  operating  and synergistic
benefits that may  be realized  through the combination  of entities.
Amounts allocated to  the Synergen,  Inc. assets and  liabilities are
based on  estimated fair  values derived  from  information currently
available.  The  Amgen Inc.  unaudited pro forma  condensed combining
financial statements,  including  Notes thereto,  should  be  read in
conjunction with the historical  consolidated financial statements of
Amgen Inc. and Synergen, Inc. covering those periods.
                              
                              F-23
<PAGE>
                                  AMGEN INC.
              UNAUDITED PRO FORMA CONDENSED COMBINING BALANCE SHEET
                             As of September 30,1994
                                 (In thousands)
<TABLE>
<S>                                  <C>           <C>          <C>              <C>
                                                                 Pro Forma        Pro Forma
                                        Amgen      Synergen     Adjustments        Combined
                                     ------------  --------     -----------      -----------
              ASSETS
Current assets:
 Cash and cash equivalents           $  301,529    $  6,271      $(254,493) (1)   $   53,307
 Marketable securites, at cost                                                    
  which approximates market             452,083     104,979              -           557,062
 Trade receivables, net                 186,220           -              -           186,220
 Inventories                             87,191           -              -            87,191
 Deferred tax assets, net                55,859           -         13,682  (1)       69,541
 Other current assets                    37,067      20,255        (19,645) (1)       37,677
                                     ----------    --------      ---------        ----------
   Total current assets               1,119,949     131,505       (260,456)          990,998

Property, plant and equipment at
 cost, net                              625,515      53,899        (20,153) (1)      659,261

Deferred tax asset - noncurrent               -           -         40,466  (1)       40,466     
Investments                              92,119           -              -            92,119
Other assets                             54,892       2,658              -            57,550
Purchased research and development                                                  
 costs                                        -           -        116,367  (1)            -
                                              -           -       (116,367) (2)            
Other                                         -           -          5,818  (1)        5,818    
                                     ----------    --------      ---------        ----------
                                     $1,892,475    $188,062      $(234,325)       $1,846,212
                                     ==========    ========      =========        ==========

LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
 Accounts payable and accrued
  liabilites                         $  285,218    $  11,540     $  58,564  (3)   $  355,322
 Commercial paper                        99,602            -             -            99,602
 Current portion of long-term debt          182        6,000        (6,000) (1)          182
                                      ----------   ---------     ---------        ----------
   Total current liabilites             385,002       17,540        52,564           455,106

Long-term debt                          185,862            -             -           185,862

Commitments and contingencies

Stockholders' equity:
 Common stock                                13          259          (259) (1)           13
 Additional paid-in capital             696,883      409,557      (409,557) (1)      696,883
 Retained earnings (deficit)            624,715     (239,294)      239,294  (1)      508,348
                                              -            -      (116,367) (2)            
                                     ----------    ---------     ---------        ----------
   Total stockholders' equity         1,321,611      170,522      (286,889)        1,205,244
                                     ----------    ---------     ---------        ----------
                                     $1,892,475    $ 188,062     $(234,325)       $1,846,212
                                     ==========    =========     =========        ==========
</TABLE>        
     See notes to unaudited pro forma condensed combining financial statements
                                        
 (1) Reflects the purchase of Synergen and the allocation of the purchase 
     price, based on estimated fair market values, to the historical Synergen 
     balance sheet, including $116,367 of purchased in-process research and 
     development.
 (2) Reflects the one-time write-off of $116,367 of purchased in-process 
     research and development identified in the purchase allocation.
 (3) Reflects the accrual of liabilities of $16,295 for severance and related 
     staff costs, $16,000 for legal settlements (net of insurance recoveries), 
     $11,201 for costs to complete committed but unneeded clinical trial 
     programs, $6,000 for restructuring corporate partner arrangements, 
     and $9,068 for other costs.

                                F-24
<PAGE>                                   
                                   AMGEN INC.
         UNAUDITED PRO FORMA CONDENSED COMBINING STATEMENT OF OPERATIONS
                      For the Year Ended December 31, 1993
                      (In thousands, except per share data)
<TABLE>
<S>                                  <C>           <C>        <C>           <C>
                                                               Pro Forma     Pro Forma
                                       Amgen       Synergen   Adjustments    Combined
                                     ----------    --------   -----------   -----------
Revenues:
 Product Sales                       $1,306,322    $      -     $      -    $1,306,322
 Corporate partner revenue               48,631      13,180            -        61,811
 Royalty income                          18,889           -            -        18,889
                                     ----------    --------     --------    ----------
Total revenues                        1,373,842      13,180            -     1,387,022
                                     ----------    --------     --------    ----------

Operating expenses:
 Cost of sales                          220,046           -            -       220,046
 Research and development               255,321      88,249       (6,013) (1)  337,557
 Marketing and selling                  214,132           -            -       214,132
 General and administrative             114,295      16,986       (1,520) (1)  129,761
 Loss of affiliates, net                 12,589           -            -        12,589
 Restructuring charge                         -       2,000            -         2,000
 Legal award                            (13,900)          -            -       (13,900)
                                     ----------    --------     --------    ----------
Total operating expenses                802,483     107,235       (7,533)      902,185
                                     ----------    --------     --------    ----------
Operating income (loss)                 571,359     (94,055)       7,533       484,837
                                     ----------    --------     --------    ----------

Other income/(expense):
 Interest and other income               27,161      10,306      (12,794) (2)   24,673
 Interest expense, net                   (6,150)       (447)           -        (6,597)
                                     ----------    --------     --------    ----------
 Total other income/(expense)            21,011       9,859      (12,794)       18,076

Income (loss) before income taxes
 and cumulative effect of a change
 in accounting principle                592,370     (84,196)      (5,261)      502,913

Provision for income taxes              217,795           -      (34,548) (3)  183,247
                                     ----------    --------     --------    ----------
Income before cumulative effect of
 a change in accounting principle    $  374,575    $(84,196)    $ 29,287    $  319,666
                                     ==========    ========     ========    ==========
</TABLE>        
     See notes to unaudited pro forma condensed combining financial statements
                              (Continued next page)
                                  
(1)Reflects reduced depreciation expense based on the fair values at the date of
   acquisition of Synergen's property, plant and equipment.

(2)Reflects reduced interest income due to the reduction in Amgen's investment
   portfolio.

(3)Reflects the tax effects of the adjustments to depreciation expense, 
   interest income and for the losses incurred by Synergen during the 
   year ended December 31, 1993 for which no tax benefit was recorded.

                                  F-25
<PAGE>
                                   AMGEN INC.
         UNAUDITED PRO FORMA CONDENSED COMBINING STATEMENT OF OPERATIONS
                      For the Year Ended December 31, 1993
                      (In thousands, except per share data)
<TABLE>
<S>                                    <C>        <C>         <C>           <C>
                                                               Pro Forma     Pro Forma
                                         Amgen     Synergen   Adjustments     Combined
                                       ---------- ----------  -----------   -----------
Income (loss) before cumulative effect
 of a change in accounting principle                              
 per share:
Primary                                    $2.61      $(3.33)           -         $2.23
Fully diluted                              $2.60         N/A            -         $2.21
                                                              
Shares used in calculation of:
Primary earnings (loss) per share        143,611      25,309            -       143,611
Fully diluted earnings per share         144,322         N/A            -       144,322
</TABLE>
     See notes to unaudited pro forma condensed combining financial statements.

                                     F-26
<PAGE>
                                   AMGEN INC.
         UNAUDITED PRO FORMA CONDENSED COMBINING STATEMENT OF OPERATIONS
                  For the Nine Months Ended September 30, 1994
                      (In thousands, except per share data)
<TABLE>
<S>                                  <C>          <C>        <C>            <C>
                                                              Pro Forma      Pro Forma
                                       Amgen      Synergen   Adjustments     Combined
                                     ----------   --------   -----------    ----------
Revenues:
 Product Sales                       $1,136,001   $      -            -     $1,136,001
 Corporate partner revenue               49,727     10,781            -         60,508
 Royalty income                          19,310          -            -         19,310
                                     ----------   --------   ----------     ----------
Total revenues                        1,205,038     10,781            -      1,215,819
                                     ----------   --------   ----------     ----------

Operating expenses:
 Cost of sales                          176,803          -            -        176,803
 Research and development               235,552     53,192       (5,357) (1)   283,387
 Marketing and selling                  174,685          -            -        174,685
 General and administrative              90,397     13,062         (872) (1)   102,587
 Loss of affiliates, net                 25,678          -            -         25,678
 Restructuring and asset                                    
   impairment charge                          -     39,079      (24,082) (2)    14,997
                                     ----------   --------   ----------     ----------
Total operating expenses                703,115    105,333      (30,311)       778,137
                                     ----------   --------   ----------     ----------
Operating income (loss)                 501,923    (94,552)      30,311        437,682
                                     ----------   --------   ----------     ----------

Other income/(expense):
 Interest and other income               16,029      4,003       (9,781) (3)    10,251
 Interest expense, net                   (8,774)      (132)           -         (8,906)
                                     ----------   --------   ----------     ----------
 Total other income/(expense)             7,255      3,871       (9,781)         1,345

Income (loss) before income taxes    $  509,178   $(90,681)  $   20,530     $  439,027

Provision for taxes                     194,298          -      (27,092) (4)   167,206
                                     ----------   --------   ----------     ----------
Net income (loss)                    $  314,880   $(90,681)  $   47,622     $  271,821
                                     ==========   ========   ==========     ==========
</TABLE>
    See notes to unaudited pro forma condensed combining financial statements.
                               (Continued next page)


(1)Reflects reduced depreciation expense based on the fair values at the date of
   acquisition of Synergen's property, plant and equipment.

(2)Reflects the reversal of asset impairment charges recorded by Synergen for:
   1) its LakeCentre manufacturing facility for $22,582 and, 2) its equity
   investment in Selectide Corporation for $1,500.  Such charges are not
   required since these assets are recorded at their fair values at the date of
   acquisition. For a description of the charge recorded by Synergen, see Note 2
   of the unaudited consolidated financial statements of Synergen, Inc. and 
   subsidiaries for the period ended September 30, 1994.

(3)Reflects reduced interest income due to the reduction in Amgen's investment
   portfolio.

(4)Reflects the tax effects of the adjustments to depreciation expense, 
   interest income, the asset impairment charge and for the losses incurred 
   by Synergen during the nine months ended September 30, 1994 for which no 
   tax benefit was recorded.
                                      
                                      F-27
<PAGE>         
                                  AMGEN INC. 
         UNAUDITED PRO FORMA CONDENSED COMBINING STATEMENT OF OPERATIONS
                  For the Nine Months Ended September 30, 1994
                      (In thousands, except per share data)
<TABLE>
<S>                                    <C>        <C>           <C>            <C>
                                                                 Pro Forma     Pro Forma
                                         Amgen     Synergen     Adjustments     Combined
                                       ---------- ----------    -----------    ---------
Earnings (loss) per share:
Primary                                    $2.25     $(3.52)                       $1.94
Fully diluted                              $2.23        N/A                        $1.93

Shares used in calculation of:
Primary earnings (loss) per share        140,021     25,747                      140,021
Fully diluted earnings per share         140,948        N/A                      140,948
</TABLE>
    See notes to unaudited pro forma condensed combining financial statements
                                        
                              F-28
<PAGE>
          NOTES TO AMGEN INC. UNAUDITED PRO FORMA CONDENSED
                   COMBINING FINANCIAL STATEMENTS


1.   Basis of presentation

     The Amgen unaudited pro forma combining financial statements and
related notes  give effect  to the  Acquisition as  a purchase.   The
Amgen unaudited  pro forma  combined balance  sheet assumes  that the
Acquisition was  completed as  of September  30,  1994 and  the Amgen
unaudited pro  forma  condensed  combining  statements  of operations
assume that the Acquisition was completed  on January 1, 1993 for the
year ended December 31, 1993 and January  1, 1994 for the nine months
ended September 30, 1994.

    All interim financial data used to develop the Amgen unaudited pro
forma condensed combining balance sheet and unaudited pro forma condensed 
combining statements of operations is unaudited, but in the opinion of
Amgen  management,  reflects all adjustments necessary (consisting  only 
of  normal recurring entries) for a fair  presentation thereof.  However, 
it should be understood that accounting  measurements at  interim dates
may be  less precise than at year end.

     The Amgen unaudited pro forma condensed combining statements of
operations are not necessarily indicative of operating results which 
would have been achieved had the Acquisition been consummated as of 
January 1, 1993 or January 1, 1994 and should not be construed as 
representative of future operations.

     The  preliminary   allocation  of   the  purchase   price  among
identifiable tangible  and  intangible assets,  as  reflected  in the
accompanying pro forma financial statements, was based on an analysis
of the  fair values  of those  assets.   Specifically,  purchased in-
process technology was evaluated through  analysis of data concerning
each product  candidate.    Potential  future  cash  flows  from each
product candidate  were  discounted  to  present  value  taking  into
account  risks   associated  with   the  inherent   difficulties  and
uncertainties in  developing  product  candidates  into  viable human
therapeutics.    In   addition,  Amgen's   post-acquisition  business
strategies were  considered  as  they  relate  to  Synergen's current
product candidates.   The  above analysis  resulted  in approximately
$116,367,000  for  purchased  in-process   technology,  which,  under
generally  accepted   accounting   principles,   was   expensed  upon
completion of the Acquisition.

     For purposes of the  pro forma financial  statements, a purchase
price of $254,493,000 was allocated to  Synergen's September 30, 1994
balance sheet.    The  purchase  price  assumes  the  acquisition  of
26,175,452 shares  of  Synergen  stock  for  $9.25  per  share.    In
addition, Amgen accrued $9,750,000 related to the payment of outstanding
stock options to purchase Synergen common stock and Amgen incurred 
$2,620,000 in other acquisition related fees.

     The  unaudited  pro  forma  condensed  combining  statements  of
operations for  the year  ended December  31, 1993  and for  the nine
months ended  September  30,  1994 do  not  include  the $116,367,000
writeoff of purchased in-process technology as  it is a material non-
recurring charge.   It will  be included  in the  actual consolidated
statement of operations  of Amgen in  the quarter  ended December 31,
1994.
                              F-29
<PAGE>
                    INDEPENDENT AUDITORS' CONSENT



We consent to the use in this Form 8-K/A of Amgen Inc. dated January 31, 
1995, of our report dated February 4, 1994 accompanying the
consolidated financial statements of Synergen, Inc. for the year
ended December 31, 1993 appearing elsewhere in this Form 8-K/A.

We also consent to the incorporation by reference in the Registration
Statement (Form S-8 No. 33-5111) pertaining to the 1984 Stock Option
Plan, 1981 Incentive Stock Option Plan and Nonqualified Stock Option 
Plan of Amgen Inc., in the Registration Statement (Form S-8 No. 33-24013) 
pertaining to the 1988 Stock Option Plan of Amgen Inc., in the Registration 
Statment (Form S-8 No. 33-39183)pertaining to the Amgen Employee Stock 
Purchase Plan, in the Registration Statement (Form S-8 No. 33-39104) 
pertaining to the Amgen Retirement and Savings Plan, in the Registration 
Statement (Form S-8 No. 33-42501) pertaining to the Amgen Inc. 1987 
Directors' Stock Option Plan, in the Registration Statement (Form S-8 
No. 33-42072) pertaining to the Amgen Inc. 1991 Equity Incentive Plan, 
in the Registration Statement (Form S-8 No. 33-47605) pertaining to the 
Retirement and Savings Plan for Amgen Manufacturing, Inc. and in the 
Registration Statements (Form S-3 No. 33-22544 and Form S-3 No. 33-44454) 
of Amgen Inc. and in the related Prospectuses of our report dated 
February 4, 1994 accompanying the consolidated financial statements 
of Synergen, Inc. for the year ended December 31, 1993 appearing 
in this Form 8-K/A of Amgen Inc. dated January 31, 1995.

/s/ DELOITTE & TOUCHE LLP
Denver, Colorado

January 31, 1995
                              
                              F-30





































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