AMGEN INC
SC 13D, 1998-12-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
 
 
                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                   Under the Securities Exchange Act of 1934
                             (Amendment No.  )*



                           NPS PHARMACEUTICALS, INC.
________________________________________________________________________________
                               (Name of Issuer)


                         Common Stock, $.001 par value
________________________________________________________________________________
                         (Title of Class of Securities)


                                   62936P103
        _______________________________________________________________
                                (CUSIP Number)

                              George A. Vandeman
                            One Amgen Center Drive,
                    Thousand Oaks, California   91320-1789
________________________________________________________________________________
(Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                Communications)

                                March 22, 1996
        _______________________________________________________________
            (Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of (S)(S)240.13d-1(e), 240.13d-1(f) or 240.13d-7(g), check the
following box [_].

Note:  Schedules filed in paper format shall include a signed original and five 
copies of the schedule, including all exhibits. See (S) 240.13d-7(b) for 
other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>
 

                                 SCHEDULE 13D
- -----------------------                                  ---------------------
CUSIP NO. 62936P103                                       PAGE 2 OF 10 PAGES
- -----------------------                                  ---------------------
 
- ------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                          
      AMGEN INC.                                   
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 
- ------------------------------------------------------------------------------
      SOURCE OF FUNDS (SEE INSTRUCTIONS)
 4    
      NC
- ------------------------------------------------------------------------------
      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
      TO ITEMS 2(d) or 2(e) [_]
 5    
- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 6    
      DELAWARE
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     7     
     NUMBER OF            1,000,000 shares
                             
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      8    
                          0 shares
     OWNED BY                    
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     9     
    REPORTING             1,000,000 shares
                         
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          10   
                          0 shares       
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
11    
      1,000,000 shares
      
- ------------------------------------------------------------------------------
      CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
12    (SEE INSTRUCTIONS)
      [_]
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
13    
      8.11%            
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
14
      CO
- ------------------------------------------------------------------------------

<PAGE>
 
Item 1.  Security and Issuer
- ------                        

     This statement is filed under Section 13(d) of the Securities Exchange Act
of 1934, as amended ("Exchange Act") and relates to shares of Common Stock of
$0.001 par value ("Common Stock"), of NPS Pharmaceuticals, Inc., a Delaware
corporation (the "Issuer").  The Principal executive offices of the Issuer are
located at 420 Chipeta Way, Salt Lake City, Utah, 84108-1256.


Item 2.  Identity and Background
- ------                          

1.      (a)   Reporting Person:        Amgen Inc. ("Amgen")
 
        (b)   Place of Organization:   Delaware
 
        (c)   Principal Business:      Pharmaceuticals

              Principal Business Address:

              Amgen Inc.
              One Amgen Center Drive
              Thousand Oaks, CA  91320-1799

              Principal Office:  (See above address)

        (d)   See 2(d) and (e) below


2.      (a)  Enumerated Persons:

          The executive officers and directors of Amgen are as follows:

              Name                       Position Held with Amgen              
              ----                       ------------------------              
                                                                               
          Mr. Gordon M. Binder           Chairman of the Board;                
                                         Chief Executive Officer               
                                                                               
          Mr. Kevin W. Sharer            President, Chief Operating            
                                         Officer, member of the Board          
                                                                               
          Dr. N. Kirby Alton             Senior Vice President -               
                                         Development                           

                                       3
<PAGE>
 
          Mr. Stanley M. Benson          Senior Vice President - Sales and     
                                         Marketing                             
                                                                               
          Ms. Kathryn E. Falberg         Senior Vice President - Finance and
                                         Chief Financial Officer 
                                                                               
          Dr. Dennis M. Fenton           Senior Vice President - Operations    
                                                                               
          Mr. Edward F. Garnett          Vice President - Human Resources      
                                                                               
          Mr. Daryl D. Hill              Senior Vice President - Quality       
                                         and Compliance                        
                                                                               
          Dr. George Morstyn             Vice President, Product               
                                         Development and Chief Medical         
                                         Officer                               
                                                                               
          Mr. Steven M. Odre             Vice President - Intellectual Property
                                         and Associate General Counsel         
                                                                               
          Dr. Lawrence M. Souza          Senior Vice President - Research      
                                                                               
          Mr. George A. Vandeman         Senior Vice President - Corporate     
                                         Development, General Counsel          
                                         and Secretary                         
                                                                               
          Mr. William K. Bowes, Jr.      Director                              
                                                                               
          Mr. Jerry D. Choate            Director                              
                                                                               
          Mr. Frederick W. Gluck         Director                              
                                                                               
          Mr. Franklin P. Johnson, Jr.   Director                              
                                                                               
          Mr. Steven Lazarus             Director                              
                                                                               
          Dr. Gilbert S. Omenn           Director                              
                                                                               
          Ms. Judith C. Pelham           Director                               

                                       4
<PAGE>
 
     (b)  Business address:

          The business address of the above named individuals are as follows:

          Binder, Sharer, Benson,        Amgen Inc.
          Fenton, Garnett, Hill, Messrs  One Amgen Center Drive
          Odre, Souza and Vandeman;      Thousand Oaks, CA  91320-1799
          Ms. Falberg, Drs. Alton,
          Morstyn, and Souza

          Mr. Bowes                      U.S. Venture Partners
                                         2180 Sand Hill Road, Suite 300
                                         Menlo Park, California  94025

          Mr. Choate                     Allstate Insurance Company
                                         2775 Sanders Road, Suite F9
                                         Northbrook, Illinois  60062

          Mr. Gluck                      743 San Ysidro Road
                                         Santa Barbara, California  93108

          Mr. Johnson                    Asset Management Partners
                                         2275 East Bayshore Road
                                         Suite 150
                                         Palo Alto, California  94303

          Mr. Lazarus                    ARCH Venture Partners, L.P.
                                         O'Hare Plaza
                                         8735 W. Higgins Road
                                         Suite 235
                                         Chicago, Illinois  60631

          Dr. Omenn                      University of Michigan
                                         Health System
                                         1301 Catherine Drive
                                         Room M7324
                                         Ann Arbor, Michigan  48109

          Ms. Pelham                     Mercy Health Services
                                         34605 Twelve Mile Road
                                         Farmington Hills, Michigan  48331

                                       5
<PAGE>
 
     (c)  Principal Employment, Name of Employer, Principal Business:

          Binder, Sharer, Benson, Fenton, Garnett, Hill, Messrs, Odre, and
          Vandeman, Ms. Falberg, Drs. Alton, Morstyn and Souza are employed by
          Amgen Inc. in the capacities named above.

          Mr. Bowes is a general partner of U.S. Venture Partners, a venture
          capital investment entity, whose address is given above.

          Mr. Choate is the Chairman and Chief Executive Officer of Allstate
          Insurance Company whose address is given above.

          Mr. Gluck is the retired Vice Chairman of Bechtel Group, Inc. whose
          address is given above.

          Mr. Johnson is a general partner of Asset Management Partners, a
          venture capital limited partnership, whose address is given above.

          Mr. Lazarus is the managing general partner of ARCH Venture Partners,
          L.P., an early stage venture capital partnership, whose address is
          given above.

          Dr. Omenn is the Executive Vice President for Medical Affairs for the
          University of Michigan Health System, whose address is given above.

          Ms. Pelham is President and Chief Executive Officer of Mercy Health
          Services, a unified system of institutions, programs and services,
          whose address is given above.



     (d) & (e) During the last five years, neither Amgen, nor, to the best of
               its knowledge, any of its executive officers or directors (i) has
               been convicted in a criminal proceeding (excluding traffic
               violations or similar misdemeanors); or (ii) has been a party to
               a civil proceeding of a judicial or administrative body of
               competent jurisdiction and as a result of such proceedings was or
               is subject to a judgment, decree or final order enjoining future
               violations of, or prohibiting or mandating activities subject to,
               federal or state securities laws or finding any violation with
               respect to such laws.

     (f)  With the exception of Dr. George Morstyn, who is a citizen of
          Australia, all of the persons enumerated above are citizens of the
          United States of America.

                                       6
<PAGE>
 
Item 3.  Source and Amount of Funds or Other Consideration
- ------                                                                   

NA


Item 4.  Purpose of the Transaction
- ------                                                          

          As set forth below in Item 6, the Shares were purchased on March 22,
1996 in connection with the Development and License Agreement Dated March 18,
1996, effective December 27, 1995, between the Issuer and Amgen (the "License
Agreement") and pursuant to the terms of the Stock Purchase Agreement made as of
March 18, 1996 between the Issuer and Amgen (the "Stock Purchase Agreement").

          Amgen has no present plan or proposal which relates to or would result
in any of the outcomes covered in subsections (a) through (j) of this Item 4.
Further, as described below in Item 6, pursuant to the standstill provisions of
the Stock Purchase Agreement, unless certain circumstances have occurred, Amgen
is restricted from participating in activities that would result in any of the
outcomes covered in subsections (a) through (j) of this Item 4.

Item 5.  Interest in Securities of the Issuer
- ------                                                                    

(a)  As of the date of this Schedule 13D, Amgen beneficially owns 1,000,000
     shares of the Issuer's Common Stock (the "Shares") which is approximately
     8.11% of the outstanding shares of the Issuer's Common Stock as identified
     in the Issuer's Quarterly Report on Form 10-Q for the quarter ended 
     September 30, 1998.

(b)  Amgen has the sole power to vote or to direct the vote and sole power to
     dispose or to direct the disposition of the Shares.

(c)  There were no other transactions in the Common Stock of the Issuer that
     were effected during the past sixty days by Amgen.

(d)  To the best knowledge of Amgen, no person other than Amgen has the right to
     receive or the power to direct the receipt of dividends from, or the
     proceeds from the sale of the Shares.

(e)  NA

                                       7
<PAGE>
 
ITEM 6.  Contracts, Arrangements, Understandings or Relationships with
- ------                                                                          
         Respect to Securities of the Issuer

License Agreement.

          On March 18, 1996, Amgen and the Issuer entered into the License
Agreement, effective December 27, 1995, which agreement is incorporated by
reference hereto as Exhibit 10.1, which grants Amgen the exclusive right to
develop and commercialize compounds for the treatment of hyperparathyroidism and
indications other than osteoporosis worldwide, excluding Japan, China, Korea and
Taiwan. Separately and also on March 18, 1996, and in connection with the
License Agreement, Amgen and the Issuer entered into the Stock Purchase
Agreement, which agreement is incorporated by reference hereto as Exhibit 10.2,
pursuant to which Amgen agreed to purchase the Shares at the price of the
Issuer's Common Stock in November 1995 (when the License Agreement was
negotiated) for an aggregate purchase price of $7.5 million.

Stock Purchase Agreement.

          Under the Stock Purchase Agreement, Amgen has certain rights and
restrictions with respect to both the Shares and the securities of the Issuer.
On March 20, 1996, pursuant to the Stock Purchase Agreement, the Issuer filed a
shelf registration statement on form S-3 for the exclusive use of Amgen to
register the Shares which the Issuer, pursuant to the terms of the Stock
Purchase Agreement, shall keep effective until March 22, 1999. Under such
registration statement and with the occurrence of certain circumstances, the
issuer may enforce suspension or holdback periods, which may remain in force up
to 120 days or 135 days, respectively, during which Amgen may not dispose of any
of the Shares.

          Stock Purchase Agreement Standstill Provisions.

               Also under the Stock Purchase Agreement, Amgen has agreed to
     certain other restrictions on its actions consistent with their investment
     in the Issuer.  Until the earlier of (a) March 22, 2001, (b) the occurrence
     of certain changes in control of the Issuer or (c) Amgen ceasing to own 5%
     of the outstanding voting securities of the Issuer, Amgen and/or its
     affiliates, shall not, without the prior approval of the Issuer's Board of
     Directors:  (i) acquire more than 20% of the total voting power of the
     Issuer; (ii) solicit proxies with respect to such securities; (iii) take
     actions to convene shareholders of the Issuer; (iv) propose any tender or
     exchange offer for securities of the Issuer, a merger, recapitalization or
     other extraordinary corporate transaction; (v) deposit Issuer securities
     into a voting trust or subject the Issuer securities to voting agreements,
     or grant any proxy with respect to the Issuer securities; or (vi) form,
     join or participate in a group for the purpose of acquiring, holding,
     voting or disposing of Issuer securities.

                                       8
<PAGE>
 
The Stock Purchase Agreement also contemplated registration rights.  Such
registration rights have expired.


ITEM 7.  Material to be Filed as Exhibits
- ------                                                                

Exhibit 10.1:  Development and License Agreement Dated March 18, 1996 Between
NPS Pharmaceuticals, Inc. and Amgen Inc.*

Exhibit 10.2:  Stock Purchase Agreement Made as of March 18, 1996 Between NPS
Pharmaceuticals, Inc. and Amgen Inc.*



- --------------------------------------------------------------------------------
* Incorporated by reference from NPS Pharmaceuticals, Inc. Form 10-K/A
Amendment No. 2 for the fiscal year ended December 31, 1995.  Such exhibits were
granted and subject to confidential treatment.

                                       9
<PAGE>
 
                                   SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  December 22, 1998

                                    AMGEN INC.



                                    BY: /s/ Kathryn E. Falberg
                                        ----------------------------------
                                        Kathryn E. Falberg
                                        Senior Vice President, Finance
                                        and Chief Financial Officer  
                                       
                                       10
<PAGE>
 
                                 EXHIBIT INDEX


Exhibit        Description                          Sequential
Number         --------------                          Page
- ----------                                            Number
                                                   --------------

10.1           Development and License Agreement dated as of
               March 18, 1996 Between NPS Pharmaceuticals,
               Inc. and Amgen Inc. *

10.2           Stock Purchase Agreement made as of March 18,
               1996 Between NPS Pharmaceuticals, Inc. and Amgen
               Inc. *



- --------------------------------------------------------------------------------
* Incorporated by reference from NPS Pharmaceuticals, Inc. Form 10-K/A
Amendment No. 2 for the fiscal year ended December 31, 1995.


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