ACCESS PHARMACEUTICALS INC
DEFS14A, 1998-03-10
PHARMACEUTICAL PREPARATIONS
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                    SCHEDULE 14A INFORMATION

   Proxy Statement Pursuant to Section 14(a) of the Securities
   Exchange Act of 1934

                  Filed by the Registrant /x/

          Filed by a Party other than the Registrant [ ]


          Check the appropriate box:
      [ ] Preliminary Proxy Statement
      [ ] Confidential, for Use of the Commission Only (as permitted by 
          Rule 14a-6(e)(2)
      [x] Definitive Proxy Statement
      [ ] Definitive Additional Materials
      [ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12


                   ACCESS PHARMACEUTICALS, INC.
        ------------------------------------------------
        (Name of Registrant as Specified In Its Charter)

                                                      
       ----------------------------------------------------
       (Name of Person(s) Filing Proxy Statement, if other
                      than the Registrant)



     Payment of Filing Fee (Check the appropriate box):
      [x] No fee required
      [ ] Fee computed on table below per Exchange Act
          Rules 14a-6(i)(1) and 0-11.
            1) Title of each class of securities to which transaction applies:
            2) Aggregate number of securities to which transaction applies:
            3) Per unit price or other underlying value of transaction 
               computed pursuant to Exchange Act Rule 0-11 (set forth the
               amount on which the filing fee is calculated and state how it 
               was determined):
            4) Proposed maximum aggregate value of transaction:
            5) Total fee paid:
      [ ] Fee paid previously with preliminary materials.

      [ ] Check box if any part of the fee is offset as provided by Exchange 
          Act Rule 0-11(a)(2) and identify the filing for which the 
          offsetting fee was paid previously.  Identify the previous filing 
          by registration statement number, or the form or schedule and the 
          date of its filing.
               1) Amount Previously Paid:
               2) Form, Schedule or Registration Statement No.:
               3) Filing Party:
               4) Date Filed:

<PAGE>
                       ACCESS PHARMACEUTICALS, INC.
                     2600 Stemmons Freeway, Suite 176
                           Dallas, Texas 75207



To Our Stockholders:

   You are cordially invited to attend the Special Meeting of Stockholders 
of Access Pharmaceuticals, Inc. (the "Company" or "Access") to be held on 
April 14, 1998 at 10:00 a.m. local time, at the New York Athletic Club, 180 
Central Park South, New York, New York  10019, (212) 247-5100 (the "Special
Meeting").

   The Notice of Special Meeting and the Proxy Statement that follow 
describe the business to be considered and acted upon by the stockholders 
at the Special Meeting. The Board of Directors unanimously recommends that 
Access' stockholders approve the proposals. Please carefully review the
information contained in the Proxy Statement.

   Proposal 1, to be addressed at the Special Meeting, is to consider and 
act upon a proposal to amend Access' Certificate of Incorporation, as amended, 
to effect a recapitalization of the Company through a one-for-twenty 
reverse stock split of Access common stock, $.04 par value per share (the 
"Common Stock"), decrease the number of authorized shares of Common Stock 
from 60.0 million to 20.0 million and decrease the authorized shares of 
preferred stock of the Company from 10.0 million to 2.0 million (the
"Recapitalization"). This proposal will decrease the number of outstanding 
shares of Common Stock from approximately 32.6 million to 1.6 million. There 
are no preferred shares outstanding.

   PLEASE NOTE THAT THE REVERSE STOCK SPLIT WILL NOT CHANGE YOUR
PROPORTIONATE EQUITY INTERESTS IN ACCESS, EXCEPT AS MAY RESULT FROM THE
ELIMINATION OF FRACTIONAL SHARES.

   The Recapitalization of the Company is a component of an overall plan to 
finance the Company to advance research and development activities and to
apply for a listing on the NASDAQ SmallCap Market or an alternative stock 
exchange. The Recapitalization is designed to position the Company to attract
institutional investors who are precluded from purchasing low-priced 
securities.

   The Board of Directors believes that the recent per share price of the 
Company's Common Stock and the fact that it is not listed on NASDAQ or an 
exchange have had a negative effect on the marketability of Access' Common 
Stock. Management of the Company believes that a reverse stock split could 
position Access more attractively with institutional investors and retail 
stock brokers who generally have restrictions on investing in low-priced 
stocks and stocks not listed on NASDAQ or an exchange. The Company
has been advised by the investment bank retained to assist in raising 
additional funding that effecting a one-for-twenty reverse stock split would
assist theinvestment bank in marketing the proposed offering to
institutional investors. A higher stock price also could increase 
broker/dealer interest in maintaining markets in Access' stock.  Individual 
stockholders would then benefit as transaction costs relative to the
total value of stock trades may be reduced. The reverse split also could 
improve Access's ability to finance the Company's research activities by 
increasing the number of potential investors and investment vehicles.
The terms under which future financing transactions could be 

<PAGE>
concluded may also be more favorable with a higher priced stock. 
Additionally, the reverse split and the refinancing would improve Access' 
prospects for being relisted on the NASDAQ SmallCap Market or an alternate
stock exchange.

   The Board of Directors unanimously recommends that Access' stockholders 
approve the amendment to the Certificate of Incorporation to effect the
reverse stock split and recapitalization. The enclosed Proxy Statement sets 
forth more detailed information regarding the amendment and the reverse 
stock split and other proposals. Please carefully review the information 
contained in the Proxy Statement.

   WHETHER OR NOT YOU PLAN TO ATTEND THE SPECIAL MEETING, IT IS VERY
IMPORTANT THAT YOU MARK, SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD IN
THE ENVELOPE PROVIDED AS SOON AS POSSIBLE. IF YOU ATTEND THE MEETING, YOU MAY
REVOKE THE PROXY AT THAT TIME BY REQUESTING THE RIGHT TO VOTE IN PERSON.

                            Sincerely,

                            /s/ Herbert H. McDade, Jr. 
                            --------------------------
                            Herbert H. McDade, Jr.
                            Chairman of the Board of Directors

<PAGE>
                        ACCESS PHARMACEUTICALS, INC.
                      2600 Stemmons Freeway, Suite 176
                            Dallas, Texas 75207

                  NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                        to be held on April 14, 1998


   PLEASE TAKE NOTICE that the Special Meeting of Stockholders (the 
"Special Meeting") of Access Pharmaceuticals, Inc. (the "Company" or 
"Access") will be held at the New York Athletic Club, 180 Central
Park South, New York, New York  10019, (212) 247-5100, on April 14, 1998, 
at 10:00 a.m. local time. The meeting will convene for the following 
purposes:

   1.To consider and vote upon a proposal to amend the Company's Certificate 
of Incorporation, as amended, (the "Amendment") to effect a recapitalization 
(the "Recapitalization") through a one-for-twenty reverse stock split (the 
"Reverse Stock Split") pursuant to which every twenty shares of Access common 
stock, $.04 par value per share (the "Common Stock") outstanding on
the effective date of the Amendment would be converted into one share of 
common stock, $.01 par value per share ("New Common Stock"). This proposal 
will decrease the number of outstanding shares of Common Stock from
approximately 32.6 million to 1.6 million. The Amendment would also reduce 
the number of authorized shares of Common Stock from 60,000,000 shares to
20,000,000 shares. The reduction in authorized shares of Common Stock would 
in fact proportionately increase the number of authorized but unissued 
shares when compared with the number of issued and outstanding
shares before the Amendment. To avoid the existence of fractional shares of 
New Common Stock, stockholders who would otherwise be entitled to receive 
fractional shares of New Common Stock shall receive cash in lieu thereof. 
The Amendment would also decrease the authorized shares of preferred stock, 
par value $.01 per share, of the Company from 10.0 million to 2.0
million. There are currently no preferred shares outstanding.

   2.To transact such other business as may properly come before the special 
meeting or any postponements or adjournments thereof.

   Stockholders of record at the close of business on March 10, 1998, the 
record date for the Special Meeting, are entitled to receive notice of, and 
to vote at the Special Meeting and any adjournment or postponement thereof.  

   Information relating to the Reverse Stock Split and the other proposals 
is set forth in the accompanying Proxy Statement dated March 10, 1998. 
Please carefully review the information contained in the Proxy
Statement, which is incorporated into this Notice.

<PAGE>
                          By Order of the Board of
                          Directors,

                          /s/ Herbert H. McDade, Jr.
                          --------------------------
                          Herbert H. McDade, Jr.
                          Chairman of the Board of
                          Directors

Dallas, Texas
March 10, 1998

                _______________________________________________

   Stockholders are cordially invited to attend the Special Meeting in 
person. YOUR VOTE IS IMPORTANT. If you do not expect to attend the Special
Meeting, or if you do plan to attend but wish to vote by proxy, please 
complete, date, sign and mail the enclosed proxy card in the return envelope
provided addressed to Access Pharmaceuticals, Inc., c/o American Stock 
Transfer & Trust Co., 40 Wall Street, 46th Floor, New York, New York 10005 
("American Stock Transfer"). Proxies will also be accepted by transmission 
of a telegram, cablegram or telecopy provided that such telegram, cablegram 
or telecopy contains sufficient information from which it can be
determined that the transmission was authorized by the stockholder. 
American Stock Transfer & Trust Company's telecopy number is (718) 234-2287.

<PAGE>
                        ACCESS PHARMACEUTICALS, INC.
                      2600 Stemmons Freeway, Suite 176
                            Dallas, Texas 75207
                            __________________

                              PROXY STATEMENT
                            __________________

                      SPECIAL MEETING OF STOCKHOLDERS
                        To Be Held On April 14, 1998

   This Proxy Statement is furnished by Access Pharmaceuticals, Inc., a 
Delaware corporation (the "Company" or "Access"), to holders of Common Stock, 
par value $.04 per share (the "Common Stock"), in connection with the 
solicitation of proxies by the Board of Directors of the Company for use at 
the Special Meeting of Stockholders of the Company, and at any and all 
adjournments or postponements thereof (the "Special Meeting"). The Special 
Meeting will be held on Tuesday, April 14, 1998 at 10:00 a.m., local time,
at the New York Athletic Club, 180 Central Park South, New York, New York  
10019, (212) 247-5100.  This Proxy Statement and the accompanying form of 
proxy is first being sent to holders of Common Stock on or about March 11, 
1998. The Company's mailing address and the location of its principal 
executive offices are 2600 Stemmons Freeway, Suite 176, Dallas, Texas 75207, 
(214) 905-5100.

   A stockholder signing and returning the enclosed proxy may revoke it at 
any time before it is exercised by voting in person at the Special Meeting, 
by submitting another proxy bearing a later date or by giving notice in 
writing to the Secretary of the Company not later than the day prior to the 
Special Meeting. All proxies returned prior to the meeting will be voted in 
accordance with instructions contained therein.

   At the close of business on March 10, 1998, the record date for the 
Special Meeting, there were outstanding and entitled to vote 32,309,010 
shares of Common Stock. The Company has no other outstanding voting 
securities. Each outstanding share of Common Stock is entitled to one vote. 
A complete list of stockholders entitled to vote at the meeting will be
available for examination by any stockholder for any purpose germane to the 
meeting at the Company's principal executive offices, during normal business
hours, at least ten business days prior to the Special Meeting. The Bylaws 
of the Company require that a majority of the shares entitled to vote, 
present in person or by proxy, shall constitute a quorum for the conduct of 
business at the meeting. Abstentions and broker non-votes are counted for 
purposes of determining the presence or absence of a quorum for the
transaction of business. Because the proposal relating to the Amendment 
(as defined below) requires the affirmative vote of a majority of the 
outstanding shares, broker non-votes and abstentions will have the
effect of a vote against such proposal.

   All expenses in connection with solicitation of proxies will be borne by 
the Company. The Company will also request brokers, dealers, banks and voting
trustees, and their nominees, to forward this Proxy Statement and the 
accompanying form of proxy to beneficial owners and will reimburse such 
record holders for their expense in forwarding solicitation material. The 
Company expects to solicit proxies primarily by mail, but Directors, officers 
and regular employees of the Company may also solicit in person, by
telephone or by telecopy.

   The Board of Directors does not know of any matters which will be brought 
before the Special Meeting other than those matters specifically set forth 
in the Notice of Special Meeting. However, if any other matter properly 
comes before the Special Meeting, it is intended that the persons named in 
the enclosed form of proxy, or their substitutes acting thereunder, will
vote on such matter in accordance with their best judgement.

<PAGE>   
                          PROPOSAL 1


Proposed Amendment to the Certificate of Incorporation to Effect the 
Recapitalization

General

   The Company proposes to effect a recapitalization through the adoption of 
a proposed amendment (the "Amendment") to the Company's Certificate of
Incorporation, as amended, (the "Certificate"), as specified in the 
accompanying Notice of Special Meeting of Stockholders. The Amendment will 
effect a recapitalization (the "Recapitalization") of the Company through a 
one-for-twenty reverse stock split (the "Reverse Stock Split") and will 
also provide for reducing the authorized number of shares of Common
Stock after the Reverse Stock Split to 20,000,000, which would in fact 
proportionately increase the number of authorized but unissued shares of 
Common Stock when compared with the number of issued and outstanding
shares before the Amendment, and to decrease the authorized shares of 
preferred stock, par value $.01 per share (the "Preferred Stock"), of the 
Company from 10,000,000 to 2,000,000. A form of the Amendment is attached 
hereto as Exhibit A to this Proxy Statement. If the Amendment is approved by 
the stockholders, each TWENTY shares of Common Stock, par value $.04 per
share, ("Old Common Stock") outstanding on the effective date of the 
Amendment (the "Effective Date") will be converted automatically into ONE 
share of Common Stock, par value $.01 per share, ("New Common Stock") and 
the number of authorized shares of Common Stock will be reduced from 
60,000,000 to 20,000,000. To avoid the existence of fractional shares of 
New Common Stock, stockholders who would otherwise be entitled to receive 
fractional shares of New Common Stock shall receive a cash distribution in 
lieu thereof. The Effective Date of the Reverse Stock Split will be the
date on which the Amendment is filed with the Secretary of State of Delaware,
which is anticipated to be as soon as practicable following the date of the 
Special Meeting. There are currently 32,609,010 shares of Common Stock 
outstanding. There is currently no Preferred Stock outstanding.

Background of and Reasons for the Reverse Stock Split

   On February 13, 1998 the Board of Directors adopted resolutions approving 
the Amendment and directing that the Amendment be placed on the agenda for 
the consideration of the stockholders.

   The Board of Directors believes that the recent per share price of the 
Common Stock has had a negative effect on the marketability of the existing 
shares, the amount and percentage of transaction costs paid by individual 
stockholders and the potential ability of the Company to raise capital by 
issuing new shares. The Company believes there are several reasons for these
effects, as summarized below.

   There are significant restrictions imposed by most brokerage houses on 
the ability of their brokers to solicit orders or recommend the purchase of 
stocks that trade on the OTC Bulletin Board.  In the majority of cases the 
purchase of stock is limited to unsolicited offers from private investors, 
who have to comply with policies and practices involving the completion of
time-consuming forms that make the handling of lower-priced stocks 
economically unattractive. Additionally, most brokerage houses do not permit
lower-priced stocks to be used as collateral for margin accounts or to be 
purchased on margin. Further, the Board of Directors believes that the 
current per share price of the Common Stock may limit the effective
marketability of the Common Stock because of the reluctance of many 
brokerage firms and institutional investors to recommend lower-priced stocks 
to their clients or to hold them in their own portfolios. The brokerage 
commission on the purchase or sale of a lower-priced stock may also 
represent a higher percentage of the price than the brokerage commission 
on a higher-

                                   2
<PAGE>
priced issue.

   The opportunity to raise capital to support the Company's development 
activities has been reduced as a result of the delisting of the stock from 
NASDAQ in April 1995, the recent price per share of the stock and the thin 
trading of the stock. These facts have significantly reduced the number of 
potential investors, increased the cost of raising capital and limited the 
types of offerings that can be made. It is the Company's intention to seek 
re-listing of the Common Stock on the NASDAQ SmallCap Market or an
alternative stock exchange, if this proposal is approved and the Company 
otherwise meets such requirements for relisting, which can nnot be assured.

   Previously the Board of Directors requested and the shareholders approved 
a one-for-four reverse stock split which subsequently was abandoned by the 
Board of Directors pursuant to Section 242 of the Delaware General 
Corporation Law. This action was taken since the Company did not believe that 
implementing the one-for-four reverse stock split would have accomplished 
the established objective of qualifying for a NASDAQ SmallCap Market or an 
alternative stock exchange relisting as the Company did not otherwise
meet the listing requirements.

   The Company has signed a non-binding letter of intent with an investment 
bank to assist the Company to raise up to $8.0 million to fund the Company's 
research and development activities. The investment bank has advised the 
Company that effecting a one-for-twenty reverse stock split would assist the 
investment bank in marketing the proposed offering to institutional
investors and would enhance the Company's ablility to meet the initial 
listing requirements for the NASDAQ SmallCap or an alternative stock exchange.
Additionally, to conclude this financing it is necessary for the Company to 
increase the authorized capital stock as currently only approximately
20,000,000 shares are available for issuance. There can be no assurance that
the Company will be able to raise funds through the proposed offering or that 
the Company will be successful in gaining a listing on the NASDAQ
SmallCap Market or an alternative stock exchange. 

   The Company expects its cash requirements to increase in future periods. 
The Company will require substantial funds to conduct research and 
development programs, preclinical studies and clinical trials of its 
potential products. The Company's future capital requirements will depend 
on many factors, including the ability to establish and maintain 
collaborative arrangements for research, development and commercialization 
of products with corporate partners, continued scientific progress in the 
Company's research and development programs, the scope and results of
preclinical testing and clinical trials, the costs involved in filing, 
prosecuting and enforcing patent claims, competing technological developments,
the cost of manufacturing and scale-up and the ability to establish and 
maintain effective commercialization activities and arrangements.  Based on 
its current plans, the Company believes that its available cash, including 
proceeds from projected interest income and potential licensing activities, 
will be sufficient to meet the Company's operating expenses and capital
requirements only into the second half of 1998 at a reduced level which 
will not support the research and development activities of the Company. 
There can be no assurance, however, that changes in the Company's operating 
expenses will not result in the expenditure of such resources 
before such time.

   The Board of Directors is optimistic that the raising of substantial 
capital, the reduction in the number of shares of Common Stock outstanding 
as a consequence of the proposed Reverse Stock Split and the resulting 
anticipated increased price level will result in greater interest in the 
Common Stock by the financial community and the investing public.

                              3
<PAGE>
   There can be no assurances, however, that the foregoing will occur or that 
the market price of the Common Stock immediately after implementation of the
proposed Reverse Stock Split will increase, and if it increases, no 
assurance that such increase can be maintained for any period of time, or 
that such market price will approximate twenty times the market price
before the proposed Reverse Stock Split.

   Dissenting stockholders have no appraisal rights under Delaware law or 
under the Company's Certificate and Bylaws in connection with Reverse Stock 
Split.

       The Company's Common Stock, since February 1, 1996, trades on the 
OTC Bulletin Board and trades under the trading symbol AXCS. Prior to this 
date the common stock traded under the trading symbol CHMX. The following 
tables set forth, for the periods indicated, the high and low closing prices 
for the Common Stock as reported by the OTC Bulletin Board for the Company's 
past two fiscal years.

<TABLE>
<CAPTION>
                           Common Stock         
                  ----------------------------------
                                        High      Low
                                      -------   -------
<S>                                  <C>       <C>
Fiscal Year Ending December 31, 1998
- ------------------------------------         
First quarter(thru February 27, 1998) $ 45/64   $   1/4

Fiscal Year Ended December 31, 1997
- -----------------------------------
First quarter                         $1-9/32   $ 23/32
Second quarter                          55/64      3/8
Third quarter                            1/2       3/16
Fourth quarter                          45/64     13/64

Fiscal Year Ended December 31, 1996
- -----------------------------------
First quarter                         $2-11/16  $  7/8
Second quarter                         2-9/16    1-5/8
Third quarter                          1-11/16     7/8
Fourth quarter                         1-5/16      3/4

</TABLE>

     The Reverse Stock Split may be abandoned by the Board of Directors 
pursuant to Section 242 of the Delaware General Corporation Law at any time 
before, during or after the Special Meeting and prior to the effectiveness 
of the filing of the Certificate of Amendment to the Company's Certificate 
of Incorporation with the Secretary of State of the State of Delaware
giving effect to the Reverse Stock Split if, for any reason, the Board of 
Directors deems it advisable to do so.

   The Board of Directors has determined that it would be appropriate for the 
Company to increase the proportionate  number of authorized shares of Common
Stock in order to have additional shares available for
possible future acquisition or financing transactions and other issuances, 
or to satisfy requirements for additional reservations of shares by reason of 
future transactions which might require increased reservations. The Board 
of Directors believes that the complexity of customary financing, employment 
and acquisition transactions requires that the directors be able to respond 
promptly and effectively to opportunities that involve the issuance of shares 
of Common Stock. For example, if the proposal is approved, the Company will 
have the flexibility to authorize stock dividends and to enter into joint 
ventures and corporate financing involving the issuance of shares of 

                                    4
<PAGE>
Common Stock. Other than the proposed financing discussed above, the Company 
has no present plans, agreements, understandings or arrangements regarding 
transactions expected to require the issuance of additional shares of Common 
Stock that would be authorized by the proposed amendment. No further
authorization for the proposed financing will be solicited from the 
stockholders.

Effects of the Reverse Stock Split and Recapitalization

   General Effects.  If the Amendment is approved by the stockholders, the 
principal effect of the Reverse Stock Split will be to decrease the number 
of outstanding shares from 32,609,010 shares to approximately 1,630,450 
shares, based on share information as of March 10, 1998, reduce the number
of authorized shares of Common Stock from 60,000,000 to 20,000,000, and 
decrease the authorized shares of preferred stock of the Company from 
10,000,000 to 2,000,000. There are currently no preferred shares
outstanding.

   In order that the Company may avoid the expense and inconvenience of 
issuing and transferring fractional shares of New Common Stock, stockholders 
who would otherwise be entitled to receive a fractional share of New Common 
Stock ("Fractional Stockholders") shall receive payment in cash in lieu of 
receiving a fractional share of New Common Stock. See "Exchange of Shares 
and Payment in Lieu of Issuance of Fractional Shares."

   Effect on Market for Common Stock.  The Reverse Stock Split may leave 
certain stockholders with one or more "odd-lots" of new Common Stock, i.e. 
stock in amounts of less than 100 shares. These odd-lots may be more 
difficult to sell or require greater transaction cost per share to sell, 
than shares in even multiples of 100.  On February 27, 1998, the closing sale 
price of the Common Stock on the OTC Bulletin Board was $0.28125 per share. 
Upon the effectiveness of the Reverse Stock Split, the Compensation Committee 
of the Board of Directors shall make a proportional downward adjustment
to the number of shares subject to outstanding options and a corresponding 
upward adjustment in the per share exercise prices to reflect the Reverse 
Stock Split.

   Changes in Stockholders' Equity.  As an additional result of the Reverse 
Stock Split, the Company's stated capital, which consists of the par value 
per share of Common Stock multiplied by the number of shares of Common 
Stock issued, will be reduced by approximately $1,304,360 to $16,304 on the 
Effective Date. Following the Reverse Stock Split, the stated capital will 
be decreased because the number of shares issued and outstanding will be 
reduced and because the par value of the Common Stock will change from $.04 
to $.01 per share.  Correspondingly, the Company's capital in excess of par 
value, which consists of the difference between the Company's stated capital 
and the aggregate amount paid to the Company upon the issuance by the
Company of all currently outstanding Common Stock, will be increased by 
approximately $1,288,056.

                      FEDERAL INCOME TAX CONSEQUENCES

   The following summary of the federal income tax consequences of the 
Reverse Stock Split is based on current law, including the Internal Revenue 
Code of 1986, as amended (the "Code"), and is for general information only. 
The tax treatment of a stockholder may vary depending upon the particular 
facts and circumstances of such stockholder. Certain stockholders, 
including insurance companies, tax-exempt organizations, financial 
institutions, broker-dealers, non-resident aliens, foreign corporations and 
persons who do not hold the Common Stock as a capital asset, may be subject 
to special rules not discussed below. 

ACCORDINGLY, EACH STOCKHOLDER SHOULD CONSULT HIS TAX ADVISOR TO
DETERMINE THE PARTICULAR TAX CONSEQUENCES TO HIM OF THE REVERSE STOCK
SPLIT, INCLUDING 

                                    5
<PAGE>
THE APPLICATION AND EFFECT OF FEDERAL, STATE, LOCAL OR
FOREIGN INCOME TAX AND OTHER LAWS.

   The receipt of shares of New Common Stock (excluding fractional shares of 
New Common Stock) in the Reverse Stock Split should be a nontaxable 
transaction under the Code for federal income tax purposes. Consequently,
a stockholder receiving shares of New Common Stock should not recognize 
either gain or loss, or any other type of income, with respect to whole 
shares of New Common Stock received as a result of the Reverse Stock
Split. In addition, the aggregate tax basis of such stockholder's shares of 
Common Stock prior to the Reverse Stock Split will carry over in computing 
the tax basis of the stockholder's shares of New Common Stock. Each
Stockholder will be required to allocate his basis in his shares of Common 
Stock ratably among the aggregate of (i) total number of shares of New 
Common Stock owned following the Reverse Stock Split and (ii) the fractional 
share, if any, in lieu of which cash is received. The holding period of the
shares of New Common Stock will include the holding period during which the 
stockholder held the Common Stock, provided that such Common Stock was held
by the stockholder as a capital asset on the Effective Date.

   The receipt by a stockholder of cash in lieu of a fractional share of New 
Common Stock pursuant to the Reverse Stock Split will be a taxable
transaction for federal income tax purposes. The receipt of cash in lieu of 
a fractional share of New Common Stock will result in gain or loss (rather 
than dividend income) to such a stockholder assuming, as the Company believes,
that such cash distribution is undertaken solely for the purpose of saving 
the Company the expense and inconvenience of issuing and transferring 
fractional shares of New Common Stock. The amount of gain or loss realized 
will be equal to the cash received, less the basis allocated to the
fractional share as discussed in the preceding paragraph. To the extent 
that a shareholder held shares of Common Stock for more than one year as of 
the Effective Date, any capital gain or loss realized will be long-term 
capital gain or loss. Long-term capital gain or loss realized by a 
shareholder that is an individual, estate or trust may be eligible to be 
taxed at reduced rates if the the Common Stock was held for longer
than eighteen months as of the Effective Date.

   Based on certain exceptions contained in regulations issued by the 
Internal Revenue Service, the Company does not believe that it or stockholders
receiving cash in lieu of fractional shares will be subject to backup 
withholding or informational reporting with respect to such cash.

               EXCHANGE OF SHARES AND PAYMENT IN LIEU OF
                    ISSUANCE OF FRACTIONAL SHARES

   On or after the Effective Date, the Company will mail to each stockholder
a letter of transmittal. A stockholder will be able to receive his shares of 
New Common Stock and, if applicable, cash in lieu of a fractional share of 
New Common Stock only by transmitting to the Transfer Agent such 
stockholder's stock certificate(s) for shares of Common Stock 
outstanding prior to the Reverse Stock Split, together with the 
properly executed and completed letter of transmittal and such 
evidence of ownership of such shares as the Company may require. 
Stockholders will not receive certificates for shares of New 
Common Stock unless and until the certificates representing their shares 
of Common Stock outstanding prior to the Reverse Stock Split are surrendered.  

   STOCKHOLDERS SHOULD NOT FORWARD THEIR CERTIFICATES TO THE TRANSFER
AGENT UNTIL THE LETTER OF TRANSMITTAL IS RECEIVED AND SHOULD SURRENDER
THEIR CERTIFICATES ONLY WITH SUCH LETTER OF TRANSMITTAL.

                                   6
<PAGE>
   No scrip or fractional share certificates for New Common Stock will be 
issued in connection with the Reverse Stock Split. A payment in lieu of a 
fractional shares of New Common Stock will be made to a Fractional
Stockholder promptly after receipt of a properly completed letter of 
transmittal and stock certificate(s) for all of his shares of Common Stock
outstanding prior to the Reverse Stock Split. 

   There will be no service charges payable by the stockholders of the 
Company in connection with the exchange of their certificates.

   FOR THE REASONS STATED ABOVE, THE BOARD OF DIRECTORS UNANIMOUSLY
RECOMMENDS THAT ALL STOCKHOLDERS VOTE "FOR" THE APPROVAL FOR THE
AMENDMENT.

      Security Ownership of Certain Beneficial Owners and Management

     Based solely upon information made available to the Company, the 
following table sets forth certain information with respect to the 
beneficial ownership of Common Stock as of January 31, 1998 by (i) each 
person who is known by the Company to beneficially own more than five 
percent of Common Stock; (ii) each director of the Company; (iii) each of 
the executive officers; and (iv) all executive officers and directors as a
group.  Except as otherwise indicated, the holders listed below have sole 
voting and investment power with respect to all shares of Common Stock 
beneficially owned by them.

<TABLE>
<CAPTION>
              Common Stock Beneficially Owned
              -------------------------------

                                 No. of        % of 
    Name                        Shares(1)     Class
- -------------------------      ----------    -------
<S>                            <C>           <C>
Herbert H. McDade. Jr.(2)       1,025,665       3.2%
Kerry P. Gray(3)                1,145,790       3.6%
J. Michael Flinn(4)                72,833        *
Stephen B. Howell(5)               91,667        *
Max Link(6)                        76,667        *
W. Eric Bowditch                   57,500        *
Stephen B. Thompson                55,451        *
Richard G. Van Inwegen             91,077        *
David F. Ranney                 9,147,608      28.6%
Nicholas Madonia, 
 Individually and as 
 Trustee(7)                     6,617,729      19.9%

All Directors and Executive 
 Officers as a group
 (consisting of 8 persons)      2,536,498       7.7% 

</TABLE>
- -----------------------------------------------------------
* Less than 1%

(1)Includes Common Stock held plus all options and warrants exercisable 
within 60 days after January 31, 1998.  Unless otherwise indicated, the 
persons listed have sole voting and investment powers with respect to
all such shares.

(2)Including presently exercisable options for the purchase of 30,883 shares 
of Common Stock pursuant to the Non-Employee Director Plans of 1987 and 1995, 
and 320,625 shares of Common Stock and 151,829 SARs exercisable pursuant to 
the 1987 Stock Option 

                                    7
<PAGE>
Plan.

(3)Including presently exercisable options for the purchase of 75,000 shares
of Common Stock pursuant to the 1995 Stock Option Plan.

(4)Including presently exercisable options for the purchase of 63,333 shares
of Common Stock pursuant to the Non-Employee Director Plans of 1987 and 1995.

(5)Including presently exercisable options for the purchase of 36,667 shares
of Common Stock pursuant to the Non-Employee Director Plan of 1995 and 15,000
shares of Common Stock pursuant to the 1987 Stock Option Plan.

   (6)Including presently exercisable options for the purchase of 36,667 
shares of Common Stock pursuant to the Non-Employee Director Plan of 1995.

(7)Mr. Nicholas Madonia owns 18,800 shares of Common Stock. Mr Madonia is 
the trustee of the Sentinel Charitable Remainder Trust ("Sentinel"), 30 
Outwater Lane, Garfield, New Jersey, which is known to Access to
be the beneficial owner of more than five percent of the Common Stock. 
In addition to 1,544,799 shares of Common Stock held by Sentinel, Sentinel 
has an option to purchase until January 1, 1999, up to 500,000 units
at $2.50 per unit.  The units consist of 500,000 shares of Common Stock, 
500,000 warrants with an expiration date of January 1, 2000 and an exercise 
price of $6.25 and 200,000 Warrants with an expiration date of January
1, 2000 and an exercise price of $2.50.  

Mr. Madonia is also the trustee of the Century Charitable Remainder Trust, 
the Ocean Charitable Remainder Trust, the Lake Charitable Remainder Trust,
the Beacon Charitable Remainder Trust, the Freedom Charitable Remainder 
Trust, the Oak Charitable Remainder Trust and the Celestial Charitable 
Remainder Trust (together, the "Charitable Remainder Trusts"). The 
Charitable Remainder Trusts are known by Access to be the beneficial owners 
of an aggregate of 930,239 shares of Common Stock and as such Mr. Madonia, 
as trustee is deemed to be a beneficial owner of the securities held by 
them. Mr. Madonia is also the trustee of the Blech Family Trust, beneficial 
owner of 2,923,891 shares of Common Stock, and as such may be deemed to be 
a beneficial owner of the securities held by it. Mr. Madonia disclaims 
beneficial ownership of all shares held by the trusts. The information set
forth in this footnote is based on a Schedule 13D filed by Mr. Madonia on 
April 9, 1997.

                         OTHER MATTERS

   As of the date of this Proxy Statement, the Board of Directors of the 
Company has no knowledge of any matters to be presented for consideration 
at the Special Meeting other than those referred to above. If (i) any 
matters not within the knowledge of the Board of Directors as of the date of 
this Proxy Statement should properly come before the meeting; (ii) any
proposals properly omitted from this Proxy Statement and the form of proxy 
should come before the meeting; or (iii) any matters should arise incident 
to the conduct of the meeting, then the proxies will be voted in accordance 
with the recommendations of the Board of Directors of the Company.

   EACH STOCKHOLDER IS URGED TO COMPLETE, DATE, SIGN AND RETURN THE
ENCLOSED PROXY CARD IN THE ENCLOSED ENVELOPE PROVIDED FOR THAT PURPOSE
AND ADDRESSED TO ACCESS PHARMACEUTICALS, INC. c/o AMERICAN STOCK TRANSFER
& TRUST CO.,  40 WALL STREET, 46TH FLOOR, NEW YORK, NEW YORK 10005, A PROMPT
RESPONSE IS HELPFUL AND YOUR COOPERATION WILL BE APPRECIATED.

                          By Order of the Board of
                          Directors,

                          /s/ Herbert H. McDade, Jr.
                          ---------------------------
                          Herbert H. McDade, Jr.
                          Chairman of the Board of
                          Directors

                                   8
<PAGE>
Exhibit A
               PROPOSED CERTIFICATE OF AMENDMENT
                            TO THE 
                 CERTIFICATE OF INCORPORATION
                              OF
                 ACCESS PHARMACEUTICALS, INC.

Access Pharmaceuticals, Inc. (the "Corporation"), a
Delaware corporation, DOES HEREBY CERTIFY:

FIRST: That at a meeting of the directors of the 
Corporation, a resolution was duly adopted setting  
forth a proposed amendment of the Certificate of
Incorporation of the Corporation, as previously
amended, and declaring such amendment to be advisable
and calling a meeting of the stockholders of the
Corporation for consideration thereof.  The resolution
setting forth the proposed amendment is as follows:

RESOLVED: Upon this Certificate of Amendment to the
Certificate of Incorporation becoming effective
pursuant to the Delaware General Corporate Law (the
"Effective Time"), each TWENTY outstanding shares of
common stock, par value $.04 per share ("Common
Stock"), shall thereupon be reclassified and changed
into ONE share of common stock, par value $.01 per
share ("New Common Stock"). Upon such Effective Time,
each holder of Common Stock shall thereupon
automatically be and become the holder of ONE share of
New Common Stock for every TWENTY shares of Common
Stock then held by such holder. Upon such Effective
Time, each certificate formerly representing a stated
number of shares of Common Stock shall thereupon be
deemed for all corporate purposes to evidence ownership
of New Common Stock in the appropriately reduced whole
number of shares. As soon as practicable after such
Effective Time, stockholders as of the date of the
reclassification will be notified thereof and, upon
their delivery of their certificates of Common Stock to
the Company, will be sent stock certificates 
representing their shares of New Common Stock, rounded
down to the nearest whole number, together with cash
representing the fair value of such holder's fractional
shares of Common Stock. No scrip or fractional share
certificates for Common Stock will be issued in
connection with this reverse stock split.

RESOLVED:  That it is advisable that Article V. Section
A and Section B of the Corporation's Certificate of
Incorporation, as amended, be amended to read in its
entirety as follows; and that such Article V, Section
A and Section B of the Corporation's Certificate of
Incorporation, as amended, be amended to read in its
entirety as follows:

     The aggregate number of shares of common stock
which the Corporation shall have authority to
        issue is Twenty Million (20,000,000) shares
with a par value of one cent ($0.01) per share.
     
     The aggregate number of shares of preferred stock
which the Corporation shall authority to issue is Two
Million (2,000,000) shares with a par value of one cent
($0.01) per share in one or more series. Each series of
preferred stock shall be designated by the board of
directors so as to distinguish the shares thereof and
the shares of all other series and classes. The board
of directors may, by resolution, from time to time
divide shares of the preferred stock into  series and
fix and determine the number of shares and the relative
rights and preferences of any series so established,
which relative rights and preferences may be greater or
lesser than those granted to the common stock as
provided herein. Notwithstanding the foregoing, all 
shares of preferred stock shall be identical, except as
to the following relative rights and preferences, in
respect of any or all of which there may be variations
between different series, namely, the rate of dividends
(including the date from which dividends shall be
cumulative), the price at, and the terms and conditions
on which, shares may be redeemed, the amounts payable
on shares in the event of voluntary or involuntary
liquidation or dissolution, sinking fund provisions for
the redemption or purchase of shares in the event
shares of any series or issue with sinking fund
provisions, and the terms and conditions on which
shares of any series may be converted in the event
shares of any series are issued a privilege of
conversion. Each share of any series of


<PAGE>
                             2 
preferred stock shall be identical with all the shares
of such series. The consideration for the issuance of
shares may be paid in whole or in part in money and
other property, tangible or intangible, or in labor or
in services actually performed for the Corporation.
When payment of the consideration for which shares are
to be issued has been received or, when payment of the
capital consideration has been received and the
Corporation has received a binding obligation from the
purchaser to pay the balance of the purchase price;
such shares shall be deemed to be fully paid and not
liable for any further call or assessment thereon.

SECOND:     That thereafter, pursuant to resolution of
the Board of Directors, a meeting of the stockholders
of the Corporation was duly called and held, upon
notice in accordance with Section 222 of the General
Corporation Law of the State of Delaware at which 
meeting the necessary number of shares as required by
the General Corporation Law of the State of Delaware
voted in favor of the amendment.

THIRD: That such amendment was duly adopted in
accordance with the provisions of Section 242 of the
General Corporation Law of the State of Delaware.

FOURTH:     That the effective date of this amendment
shall be ______, 1998.


<PAGE>
                     ACCESS PHARMACEUTICALS, INC.
        2600 Stemmons Freeway, Suite 176, Dallas, Texas 75207
      THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned having received the Notice of Special Meeting of Stockholders
and Proxy Statement dated March 10, 1998, and revoking any proxy heretofore
given, hereby appoints each of Herbert H. McDade, Jr. and Kerry P. Gray or 
either of them, proxies of the undersigned with full power of substitution, 
to vote all shares of common stock of Access Pharmaceuticals, Inc. which the 
undersigned is entitled to vote at a Special Meeting of Stockholders to be 
held April 14, 1998 at 10:00 a.m., at the New York Athletic Club, 180
Central Park South, New York, New York  10019, (212) 247-5100, or any 
adjournment thereof.

This proxy when properly executed will be voted in the manner directed 
herein by the undersigned stockholder. If no direction is made, this Proxy 
will be voted FOR the Proposal.

In their discretion, the Proxies are authorized to vote on any other matters 
which may properly come before the Special Meeting or any adjournment thereof 
as set forth in the Proxy Statement.

             (continued, and to be signed on the reverse side)
                        
                                                            SEE REVERSE SIDE

[ X ]  PLEASE MARK YOUR VOTE AS IN THIS EXAMPLE

 1.Proposal to amend the Certificate of Incorporation
   to effect a recapitalization whereby the Company
   would effect a one-for-twenty reverse stock split,
   the number of authorized shares of Common Stock
   would be decreased from 60,000,000 shares, par value
   $.04 per share, to 20,000,000 shares, par value $.01
   per share, and the number of authorized shares of
   Preferred Stock would be decreased from 10,000,000
   shares, par value $.01 per share, to 2,000,000
   shares, par value $.01 per share (the
   Recapitalization).      
                              FOR     AGAINST  ABSTAIN 
                              [  ]     [  ]      [  ] 

PLEASE MARK, SIGN AND DATE BELOW AND RETURN THIS PROXY CARD PROMPTLY USING 
THE ENCLOSED ENVELOPE.

Proxies will also be accepted by transmission of a telegram, cablegram or 
telecopy provided that such telegram, cablegram or telecopy contains 
sufficient information from which it can be determined that the
transmission was authorized by the stockholder. Telegrams or cablegrams may 
be addressed to American Stock Transfer & Trust Co. ("American Stock Transfer")
at the address appearing on the attached envelope. American Stock Transfer's 
telecopy number is (718) 234-2287.

Shares Held: ___________

THIS PROXY IS SOLICITED ON BEHALF OF ACCESS PHARMACEUTICALS, INC.'S BOARD
OF DIRECTORS AND MAY BE REVOKED BY THE STOCKHOLDER PRIOR TO EXERCISE.

Signature ____________________  ________  __________________________  ________
                                Date      Signature (if held jointly) Date

NOTE: Please sign exactly as name appears hereon. Joint owners should each 
sign.  When signing as attorney, executor, administrator, trustee or 
guardian, please give full title as such.  If a corporation, please sign in 
full corporate name by President or other authorized officer.  If a 
partnership, please sign in partnership name by authorized person.




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