GENENTECH INC
S-3/A, 1995-04-03
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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As filed with the Securities and Exchange Commission on     March 31, 
1995.      

                        Registration No. 33- 54103 
======================================================================

                    SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C.  20549
                    ---------------------------------  

                            FORM S-3     A-3     
                         REGISTRATION STATEMENT
                                 UNDER
                        THE SECURITIES ACT OF 1933
                        --------------------------

                            GENENTECH, INC.
        ------------------------------------------------------
          (Exact name of registrant as specified in its charter)

        Delaware                                         94-2347624
(State or other jurisdiction                         (I.R.S. Employer
      of incorporation or                           Identification 
       organization)                                     No.)
       

                     460 Point San Bruno Boulevard
                  South San Francisco, California 94080
                           (415) 225-1000
               ------------------------------------------
            (Address, including zip code, and telephone number,
       including area code, of registrant's principal executive 
                            offices)

                          John P. McLaughlin
          Senior Vice President, General Counsel and Secretary
                            GENENTECH, INC.
                     460 Point San Bruno Boulevard
                  South San Francisco, California 94080
                           (415) 225-1000
          ----------------------------------------------------
         (Name, address, including zip code, and telephone number,
                including area code, of agent for service)

        Approximate date of commencement of proposed sale to the 
public:

As soon as possible after this Registration Statement becomes 
effective.

If the only securities being registered on this Form are being 
offered pursuant to dividend or interest reinvestment plans, please 
check the following box [ ].

If any of the securities being registered on this Form are to be 
offered on a delayed or continuous basis pursuant to Rule 415 under 
the Securities Act of 1933, other than securities offered only in 
connection with dividend or interest reinvestment plans, please check 
the following box [ X ].

<PAGE>




<TABLE>
                      CALCULATION OF REGISTRATION FEE
=====================================================================
<CAPTION>
                               Proposed                Amount
Title of Each      Proposed    Maximum     Maximum     of
Class of           Amount      Offering    Aggregate   Regis-
Securities to      to be       Price Per   Offering    tration
be Registered      Registered  Share(1)    Price (1)   Fee    
    <S>               <C>        <C>         <C>       <C>
Redeemable
Common Stock
$.02 par value     4,500,000   $48.375   $217,687,500  $75,065
shares
=====================================================================
<FN>
(1)   Based upon the average of the high and low prices of the 
Registrant's Redeemable Common Stock, as reported on the New 
York Stock Exchange on June 6, 1994, in accordance with Rule 457. 
</TABLE>
====================================================================

        This Registration Statement shall hereafter become 
effective in accordance with Section 8(a) of the Securities Act of 
1933 on such date as the Commission, acting pursuant to said Section 
8(a), may determine.     




































<PAGE>



                               GENENTECH, INC.
                              ----------------
                            Cross-Reference Sheet


   Form S-3 Item Number and Heading            Location in Prospectus

1.    Forepart of Registration
            Statement and Outside Front
            Cover Page of Prospectus                 FRONT COVER PAGE

2.    Inside Front and Outside Back
            Cover Pages of Prospectus          ADDITIONAL INFORMATION

3.    Summary Information, Risk
      Factors and Ratio of Earnings
      to Fixed Charges                                    THE COMPANY

4.    Use of Proceeds                                 USE OF PROCEEDS

5.    Determination of Offering Price                  NOT APPLICABLE

6.    Dilution                                         NOT APPLICABLE

7.    Selling Security Holders                         NOT APPLICABLE

8.    Plan of Distribution                       PLAN OF DISTRIBUTION

9.    Description of Securities to                 DESCRIPTION OF THE
      be Registered                           REDEEMABLE COMMON STOCK

10.   Interests of Named Experts
      and Counsel                                       LEGAL MATTERS

11.   Material Changes                               MATERIAL CHANGES

12.   Incorporation of Certain Information   INCORPORATION OF CERTAIN
      by Reference                             DOCUMENTS BY REFERENCE

13.   Disclosure of Commission               DISCLOSURE OF COMMISSION
      Position on Indemnification         POSITION ON INDEMNIFICATION
      for Securities Act               FOR SECURITIES ACT LIABILITIES
      Liabilities


















<PAGE>


                             GENENTECH, INC.

                    4,500,000 Shares Redeemable Common Stock
                       ---------------------------------

      This Prospectus covers 4,500,000 shares of Redeemable Common 
Stock of Genentech, Inc. issuable upon exercise of stock options 
under Genentech, Inc.'s 1994 Stock Option Plan (the "Option Plan").
                      ------------------------------------
     The Redeemable Common Stock is traded on the New York Stock 
Exchange and the Pacific Stock Exchange under the symbol GNE. On June 
6, 1994 the closing sales price for the Redeemable Common Stock on 
the New York Stock Exchange was $48.25.

    THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE
   SECURITIES AND EXCHANGE COMMISSION NOR HAS THE COMMISSION
     PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
     ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
<TABLE>
<CAPTION>
                                 Underwriting
                      Price to   Discounts and     Proceeds to 
                      Public(1)  Commissions(2)    Company(3)
- -------------------------------------------------------------------- 
    <S>                     <C>           <C>              <C>
Per Share                $48.25     $     0          $217,125,000
Total                    $48.25     $     0          $217,125,000
- --------------------------------------------------------------------
=====================================================================
<FN>
(1)    Based upon the closing price of the Redeemable Common Stock on 
June 6, 1994.  The actual price to be paid upon exercise of options will 
be determined on the date the options are granted.

(2)    Sales will be made upon the exercise of options without the 
use of underwriters or dealers and no compensation will be paid to 
any such person in connection with the sale of shares upon 
exercise of options.  See "Plan of Distribution".

(3)    Before deducting offering expenses estimated at     $91,065      
payable by the Company.
</TABLE>
                  ________________________________

             The date of this Prospectus is     March 31, 1995     


















<PAGE>


                        TABLE OF CONTENTS
                                                               Page


AVAILABLE INFORMATION                                             1
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE                   2
THE COMPANY                                                       2
USE OF PROCEEDS                                                   3
THE 1994 STOCK OPTION PLAN                                        3
Information About Genentech                                       4

A.    Regular Option Grant Program                                4

      1.  Am I eligible for option grants?                        4

      2.  Who determines the terms of my option?                  5

      3.  Do special rules apply to me if I am an officer or
          director of the Company?                                5

      4.  What happens to my option or stock issued under the
          Option Plan in the event Roche Holdings Inc. 
          ("Roche") redeems the Redeemable Common Stock?          5

      5.  How many shares of Redeemable Common Stock will my
          option cover?                                           6

      6.  How is the exercise price of an option determined?      6

      7.  When can I exercise my option?                          7

      8.  How do I exercise my option?                            7

      9.  Do I have to pay the exercise price with cash?          7

     10.  Will I continue to receive options as long as I stay
          with the Company?                                       7

     11.  Can the stockholders of the Company change the terms
          of the Option Plan?                                     8

     12.  What happens if I leave the Company?                    8

     13.  What if I leave the Company because of disability?      8

     14.  What are the rights of my heirs?                        8

     15.  Can a relative or friend exercise my option?            9

     16.  Can I transfer my options?                              9

     17.  Can I sell the stock I receive from exercising my
          option right away?                                      9

     18.  How do I sell stock I received under the option?  Do 
          I have to pay a commission when I exercise my option 
          or sell the stock I received under the option?          9





<PAGE>


     19.  I have heard about cashless exercise programs 
          through brokers, how do these work?                     9

     20.  How can I make a gift of stock I receive under the
          Option Plan?                                           10

     21.  Does the Company go out on the market to buy the 
          stock which I will receive on exercise of my option?   10

     22.  Does the Option Plan have any of the same benefits  
          as a qualified retirement plan (including a 401(k) 
          plan) and will my participation in the Option Plan 
          affect my participation in the Company's 401(k) plan?  10

     23.  Do I have to pay tax when I receive a stock option 
          or exercise the stock option?  Will the Company 
          withhold the amount of taxes due?                      11

     24.  How much tax do I have to pay when I sell stock
          received pursuant to the exercise of a non-statutory
          stock option?                                          11

     25.  What is the difference between ordinary income and
          capital gains?                                         11

     26.  When do I pay tax on stock received pursuant to the
          exercise of an incentive stock option?                 12

     27.  How is my profit taxed?  What if I lose money?         12

     28.  Is there any withholding on the exercise of my
          incentive stock option or the sale of the stock
          acquired on exercise?                                  13

     29.  Do I have to complete any forms after I sell or
          transfer my stock?                                     13

     30.  Are there any special tax rules which apply to me if
          the Company has the right to repurchase my stock  
          after I exercise my option?                            13

          NON-QUALIFIED STOCK OPTION                             14

          INCENTIVE STOCK OPTION                                 15

     31.  What are the tax consequences if I use shares I
          already own to pay the exercise price of my non-
          qualified stock option?                                16

     32.  What are the tax consequences if I use shares I
          already own to pay the exercise price of incentive
          stock options?                                         17

     33.  What are the tax consequences of my exercise of
          options if I am subject to the alternative minimum
          tax?                                                   18





<PAGE>




     34.  What happens to my option or stock issued under the
          Option Plan in the event Genentech is acquired by a
          person other than Roche?                               18

     35.  What happens if the vesting of my options  
          accelerates upon a change of control?                  19

B.    Automatic Grant Program                                    19

     36.  Are non-employee directors eligible to receive 
          options under the Option Plan?                         19

C.   Miscellaneous                                               20

     37.  What are some of the other features of the Option
          Plan?                                                  20

PLAN OF DISTRIBUTION                                             21

DESCRIPTION OF THE REDEEMABLE COMMON STOCK                       21

LEGAL MATTERS                                                    24

EXPERTS                                                          25

MATERIAL CHANGES                                                 25

DISCLOSURE OF COMMISSION POSITION ON
INDEMNIFICATION FOR SECURITIES ACT LIABILITIES                   26

                          AVAILABLE INFORMATION

       Genentech, Inc. ("Genentech" or the "Company") is subject to the 
informational requirements of the Securities Exchange Act of 1934, as 
amended (the "Exchange Act"), and, in accordance therewith, files, 
reports, proxy statements and other information with the Securities and 
Exchange Commission (the "Commission").  Such reports, proxy statements 
and other information filed by the Company with the Commission can be 
inspected and copied at the public reference facilities maintained by 
the Commission at Room 1024, 450 Fifth Street, N.W., Washington, D.C. 
20549, and should be available for copying and inspection at the 
Regional Offices of the Commission at Suite 1400, 500 West Madison 
Street, Chicago, Illinois  60661 and 7 World Trade Center, New York, New 
York 10048.  Copies of such material can also be obtained from the 
Public Reference Section of the Commission, at 450 Fifth Street, N.W. 
Washington, D.C. 20549, at prescribed rates.  The Company's Redeemable 
Common Stock is listed on the New York Stock Exchange and the Pacific 
Stock Exchange and such reports, proxy statements and other information 
concerning Genentech should be available for inspection and copying at 
their respective offices at 20 Broad Street, New York, New York 10005 
and 301 Pine Street, San Francisco, California 94104.

     The Company has filed with the Commission a Registration Statement 
under the Securities Act of 1933, as amended (the "Securities Act"), 
with respect to the Redeemable Common Stock offered by this Prospectus.  
This Prospectus does not contain all the information set forth in the 
Registration Statement.  For further information with respect to the 
Company and the securities offered by this Prospectus, reference is made
to the Registration Statement, including the exhibits filed therewith.

                                   1
<PAGE>



              INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

       The following documents filed with the Commission are 
incorporated herein by reference:

           (a) The Company's     Annual Report on Form 10-K for the
year ended December 31, 1994.    

           (b)     All reports filed pursuant to Sections 13(a) or 
15(d) of the Exchange Act since the end of the fiscal year covered by 
the annual report referred to in clause (a) above.    

           (c)     The Company's Proxy Statement dated March 17, 1995.
    
           (d) The description of the Company's Redeemable Common 
Stock (the "Redeemable Common Stock") filed pursuant to the Exchange 
Act and any amendment or report filed to update such description.

      All documents filed by the Company with the Commission pursuant 
to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the 
date of this Prospectus and prior to the filing of a post-effective 
amendment which indicates that all securities offered hereby have 
been sold or which deregisters all securities remaining unsold shall 
be deemed to be incorporated by reference in this Prospectus and to 
be a part hereof from the date of filing of such documents.  Any 
statements contained in a document incorporated by reference herein 
shall be deemed to be modified or superseded for purposes of this 
Prospectus to the extent that a statement contained herein or in any 
other subsequently filed document which also is or is deemed to be 
incorporated by reference herein modifies or supersedes such 
statement.  Any statement so modified or superseded shall not be 
deemed, except as so modified or superseded, to constitute a part of 
this Prospectus.

     The Company will provide without charge to each person to whom 
this Prospectus is delivered, upon written or oral request of such 
person, a copy of any and all of the information that has been 
incorporated by reference in the Registration Statement filed with 
the Commission under the Securities Act with respect to the 
Redeemable Common Stock offered by this Prospectus, other than 
certain exhibits to such documents.  Such requests should be directed 
to the Corporate Secretary, Genentech, Inc., 460 Point San Bruno 
Boulevard, South San Francisco, California 94080, telephone (415) 
225-1000.



                          THE COMPANY

         Genentech, Inc. is an international biotechnology Company 
that discovers, develops, manufactures and markets human 
pharmaceuticals for significant medical needs. Genentech was 
incorporated in 1976 as a California corporation but changed its 
state of incorporation in 1987 to Delaware. Genentech's executive 
offices are located at 460 Point San Bruno Boulevard, South San 
Francisco, California 94080, telephone (415) 225-1000.



                                   2
<PAGE>




                        USE OF PROCEEDS

        There can be no assurance that any options granted under the 
Option Plan will be exercised.  However, assuming all options granted 
under the Option Plan are exercised for cash and that the exercise 
price of such options is equal to the closing price of the Company's 
Redeemable Common Stock on June 6, 1994, the net proceeds to be 
received by the Company from the sale of the Redeemable Common Stock 
offered hereby are estimated to be $217,125,000.  Such proceeds will 
be used for general corporate purposes including additions to working 
capital and capital expenditures.  A portion of the net proceeds may 
also be used for the acquisition of technology or products, although 
no material acquisitions are currently being negotiated.  Pending 
such uses, the Company intends to invest such proceeds in readily 
marketable, interest-bearing securities.

THE 1994 STOCK OPTION PLAN

To our Employees, Certain Consultants and Non-Employee Directors:

     We are pleased with this opportunity to provide you with 
information regarding our 1994 Stock Option Plan, referred to as the 
"Option Plan."  We believe that the Option Plan is an important part 
of the benefits provided to our employees, certain consultants and 
non-employee directors and we hope you will take the time to 
carefully review this information.

     Genentech, Inc. adopted the Option Plan in order to provide a 
method whereby the Company may retain the services of persons now 
employed by or serving as consultants or directors to it, secure and 
retain the services of persons capable of filling such positions and 
provide incentives for such persons to exert maximum efforts for the 
success of the Company or its parent or subsidiary corporations.

     The discussion of the Option Plan describes: (i) the terms of 
the Regular Option Grant Program under the Option Plan, which 
provides for the grant of what are called incentive stock options 
(tax advantaged options) and non-statutory stock options (options 
which do not have tax advantages but which may cover stock offered at 
a discounted price); and (ii) the terms of the Automatic Grant 
Program under the Option Plan, which provides for the automatic grant 
of non-statutory stock options to non-employee members of the Board. 
It also includes a description of provisions of the Option Plan that 
are applicable to all rights granted under the Option Plan.

     The attached materials may not answer all the questions you have 
about the Option Plan and are not intended to go into every detail of 
the Option Plan, copies of which are found at the end of this 
package.  Kathy Panko, Manager of Corporate Records and Karen Strand, 
Senior Stock Services Coordinator located in the legal department 
will be happy to answer further questions.

     If you are granted a stock option under the Option Plan you will 
receive an option grant form describing the terms of your option.  If 
you wish to exercise an option you will need to complete an option 
exercise form provided with your option grant. You may always obtain 
extra copies of the option exercise form from Kathy Panko or Karen 
Strand.

                                   3
<PAGE>




       Information About Genentech

     An important part of your participation in Genentech's Option 
Plan is understanding the Company, its products, operations and 
financial condition.  Like any stockholder of the Company, you can 
keep yourself informed about the Company by reviewing reports which 
the Company prepares for stockholders and the general public.

     If you have not already received a copy of Genentech's most 
recent annual report as a current stockholder of the Company, the 
report should be delivered to you with these materials.  Whether or 
not you have already received the annual report, you may always 
request a copy from the Company.

     If you are already a stockholder of the Company or an 
optionholder, you should receive copies of the Company's proxy 
statement, reports to stockholders and other stockholder 
communications.  If you do not receive this information you should 
notify Diane Schrick, Investor Relations, Building 5, extension 1599. 
You may always request additional copies of this information.

     The United States securities laws require the Company to provide 
information about its business and financial status in annual 
reports, commonly known as "10-K's" and quarterly reports, commonly 
known as "10-Q's." These reports are filed with the Securities and 
Exchange Commission.  In addition, if important corporate events 
occur during the year, the Company may file reports commonly known as 
"8-K' s." From time to time the Company may file other documents with 
the Securities and Exchange Commission.

     All of these reports constitute part of the information required 
by securities laws to be provided or made available to you in 
connection with your purchase of stock under the Option Plan, that 
is, these reports are incorporated by reference into these materials, 
which constitute the prospectus for the Option Plan.

     For a copy of these reports, which are available without charge 
and upon written or oral request, please contact Diane Schrick, 
Investor Relations, Building 5, extension 1599 who will be happy to 
assist you.

       A.    Regular Option Grant Program

1.     Am I eligible for option grants?

      To receive an incentive stock option you must be an employee of 
the Company, its parent, or any subsidiary (any corporation in which 
the Company owns more than 50% of the outstanding voting power).  To 
receive a non-qualified stock option you must be an employee of, or a 
consultant to, the Company, its parent, any subsidiary, or any other 
business entity in which the Company directly or indirectly owns more 
than 50% of the voting power, capital or profits.  Non-employee 
directors will only receive non-qualified stock options pursuant to the 
terms of the Automatic Grant Program described below in Question 36.  
The Option Plan currently provides for the grant of options to 
directors, employees and consultants covering an aggregate of 4,500,000 
shares of the Company's Redeemable Common Stock.


                                  4
<PAGE>




2.     Who determines the terms of my option?

       The decision to grant an option to any particular individual 
is made by the Compensation Committee of the Board of Directors of 
the Company, generally after review of input from management. The 
current members of the Compensation Committee of the Board are Armin 
M. Kessler, J. Richard Munro, Thomas J. Perkins and Robert A. Swanson 
and information about them is provided in the Company's proxy 
statement for its last annual meeting.

       Members of the Board are nominated by the Board and elected by 
the stockholders of the Company.  The members of the Board are 
divided into three classes, each class consisting, as nearly as 
possible, of one-third of the total number of directors, with each 
class having a three year term.  Each director holds office until his 
or her term is complete and until his or her successor is elected, or 
until his or her death, resignation or removal. Board members may be 
removed from office by appropriate stockholder action.  The 
Compensation Committee currently consists of four board members 
appointed by the Board of Directors as a whole.

3.     Do special rules apply to me if I am an officer or director of 
the Company?

       Yes.  If you are an officer or director of the Company you 
should be aware of tax and securities laws which apply to your 
transactions in stock received upon the exercise of options or if the 
Company is bought out.  In addition, you must comply with the 
Company's policy permitting officers and directors to sell shares 
only during "window" periods which generally open on the third 
business day after a quarters' revenues and earnings have been 
publicly released and close on the tenth calendar day of the last 
month of each quarter.  Furthermore, you are expected to check with 
Kathy Panko before selling any shares and your sale must also be made 
in accordance with Rule 144.

       One of the laws that will apply to you as an officer or 
director is Section 16 of the Securities Exchange Act of 1934. If you 
are not familiar with how Section 16 operates, you should review the 
Memorandum to Officers and Directors which you should have received 
or ask Kathy Panko or Karen Strand for another copy of the 
Memorandum.

4.     What happens to my option or stock issued under the Option 
Plan in the event Roche Holdings Inc. ("Roche") redeems the 
Redeemable Common Stock?

     If the Redeemable Common Stock is redeemed by Roche, all 
outstanding options which are vested immediately prior to the date of 
the redemption will be cashed out at the excess of the per share 
redemption price over the per share option price.  Following the 
redemption, outstanding options which are not vested immediately 
prior to the date of the redemption will be replaced by a comparable 
incentive program.  If the redemption does not occur and the 
Redeemable Common Stock converts to Common Stock as provided in 
Article Third of the Company's Certificate of Incorporation, 
outstanding options shall continue to vest and become exercisable to 
purchase shares of Common Stock of the Company pursuant to the 
option's original vesting schedule.

                                   5
<PAGE>



5.     How many shares of Redeemable Common Stock will my option 
cover?

       When the Compensation Committee grants an option the 
Compensation Committee determines the number of shares the option 
will cover.  There is no minimum number of shares for which an option 
may be granted; however, the aggregate number of shares of stock that 
may be subject to options granted to any employee in a calendar year 
may not exceed two hundred fifty thousand (250,000) shares of the 
Company's Redeemable Common Stock.  Other limitations apply for 
option grants to non-employee members of the Board (see Question 36).

       The tax regulations do restrict the Board's ability to grant 
incentive stock options under the following circumstances:

     a.  if you are granted an incentive stock option that is 
immediately exercisable as to all the shares covered by the option 
and the aggregate value of the shares on the date of grant (usually 
determined on the basis of the trading price of the stock on the 
trading day immediately preceding the grant date) is greater than 
$100,000, then that number of shares with a value over $100,000 will 
be treated by the IRS as non-statutory stock options not having the 
tax advantages of incentive stock options, and
     b.  if you are granted an incentive stock option that vests over 
a period of time (i.e., the option is not exercisable immediately but 
becomes exercisable for all or a portion of the shares covered by the 
options on a date or dates stated in the option grant) and the 
aggregate value of shares (determined at the date of grant of each 
option) under that option and all other incentive stock options 
(granted after 1986) you hold, if any, become exercisable for the 
first time during any calendar year is greater than $100,000, then 
that number of those shares with a value over $100,000 will be 
treated by the IRS as non-qualified stock options not having the tax 
advantages of incentive stock options.

       In addition, as is described more fully in the answers below, 
incentive options have limitations on their exercise price, terms, 
transferability, and duration following termination.

6.     How is the exercise price of an option determined?

       IRS regulations require the exercise price of an incentive 
stock option to be at least 100% of the fair market value of the 
Company's Redeemable Common Stock on the date the option is granted. 
Because the Company's Redeemable Common Stock trades on the New York 
Stock Exchange, the fair market value will be the closing sale price 
of the Company's Redeemable Common Stock as quoted by New York Stock 
Exchange on the trading day immediately preceding the date of grant. 
We will refer to this price as the "market price." Special rules 
apply to the exercise price of incentive stock options granted to 
anyone who owns 10% or more of the voting power of the Company.

       The Option Plan provides that the Board may set the exercise 
price for a non-qualified stock option at any price not less than 50% 
of the market price of the Company's Redeemable Common Stock on the 
trading day immediately preceding the date the option is granted.



                                   6
<PAGE>





7.     When can I exercise my option?

       When the Compensation Committee grants an option, the 
Compensation Committee also determines certain terms of the option, 
including the date or dates the option may be exercised. As an 
example, options granted in April 1994 vest at the rate of 10% in 
1996, 15% in 1997, 25% in 1998 and 50% in 1999.  You may exercise 
your option at any time for the number of shares that have actually 
vested at the time of exercise.  Options granted by the Company under 
the Option Plan generally have a term of 20 years (incentive options 
may not have a term longer than 10 years), so you must exercise your 
option before it expires at the end of the 20 year period. The terms 
of exercise of options granted by the Company are not required to be 
the same for every employee and the terms of the option you receive 
may vary from the terms described above.  In addition, the 
Compensation Committee has the power to accelerate the vesting 
schedule of any outstanding option, either without conditions or 
subject to a right to repurchase "unvested" shares.  You may also 
exercise your option prior to full vesting, subject to restrictions 
described in the Option Plan, including without limitation, 
restrictions on your ability to sell unvested shares and the 
Company's ability to repurchase unvested shares at your option's 
original exercise price upon termination of your employment.

8.     How do I exercise my option?

       You exercise your option by completing an option exercise form 
and delivering the form, together with payment of the exercise price 
(in cash or stock -- see Question 9 below) to Kathy Panko or Karen 
Strand.  You should receive a copy of the option exercise form with 
your option grant.  You can obtain additional copies of the form from 
Kathy Panko or Karen Strand.

9.     Do I have to pay the exercise price with cash?

       No.  You may also pay the exercise price with Company 
Redeemable Common Stock that you have owned for more than six months. 
Such stock will be valued at its closing price on the New York Stock 
Exchange on the trading day before you exercise the option.  The 
Compensation Committee may determine, at the time of exercise of the 
option, that the exercise price may be paid in installments (or that 
the Company will make a loan or guaranty a third party loan for the 
exercise price).  The Compensation Committee will determine the terms 
and conditions of any deferred payment arrangement.

10.     Will I continue to receive options as long as I stay with the 
Company?

       Whether or not you receive stock options will depend on many 
factors such as your performance, the Company's overall performance, 
the Compensation Committee's current policy and the number of shares 
remaining in the Option Plan.  The Option Plan and therefore the 
Compensation Committee's authority to grant options, terminates on 
the date determined by the Board of Directors.  However, any such 
termination of the Option Plan will not affect your rights under your 
outstanding options without your consent.


                                   7
<PAGE>




11.     Can the stockholders of the Company change the terms of the 
Option Plan?

       Generally, the Board of Directors decides whether to change 
the terms of the Option Plan, usually because the number of shares 
available under the Option Plan should be increased or to take into 
account changes in the tax laws.  These changes may be presented for 
approval by the stockholders of the Company at the Company's annual 
meeting.  Stockholder approval will be obtained if tax, securities or 
other laws require approval of the changes.

12.     What happens if I leave the Company?

       Whether you leave the Company voluntarily or your employment 
is terminated by the Company for any reason, your right to exercise 
any vested portion of your option generally will terminate three 
months after your last day with the Company as determined between you 
and the Company.  However, the terms of your option may provide that 
it may be exercised more than three months after termination of 
employment and the Compensation Committee may, at the time of 
termination, extend vesting for a period of up to three years and 
exercisability for a period of up to five years. In the event of your 
retirement or the termination of your employment by a "plant closing" 
or "mass layoff " (as such terms are defined at 29 U.S.C. Section 
2101), the Committee shall have discretion to provide that the option 
will continue to vest during the limited period of exercisability 
according to the vesting schedule that would have applied had your 
employment continued.  However, if the option is an incentive stock 
option it must be exercised within three months of the date of 
termination or else it will become a non-statutory option.

13.     What if I leave the Company because of disability?

       If your employment is terminated because of your permanent and 
total disability it may be exercised by you or your spouse at any 
time prior to its original termination date; however, if it is an 
incentive stock option it must be exercised within twelve (12) months 
of your date of termination or else it will become a non-statutory 
stock option.  In addition, the Compensation Committee may provide, 
either at the time your option is granted or when your employment is 
terminated due to your disability, that your options will continue to 
vest up to the original date of termination of those options on the 
schedule that would have applied had your employment not been 
terminated or it may provide that your vesting will be accelerated. 
Because disability, for these purposes, has a specific meaning found 
in the Internal Revenue Code, you should ask Human Resources if you 
have any questions regarding what constitutes permanent and total 
disability.

14.     What are the rights of my heirs?

       Your estate or persons having rights to your option by will or 
by the laws of descent have the right to exercise your option at any 
time prior to its original termination date.  In addition, the 
Compensation Committee may provide, either at the time your option is 
granted or upon your death, that your option will continue to vest or 
that vesting will be accelerated.


                                  8
<PAGE>




15.     Can a relative or friend exercise my option?

       No, except for options transferred to a trust (see Question 
16) or options exercised after your death or total disability, only 
you may exercise your option during your lifetime.  You may, however, 
provide for the transfer of the option in your will.  Under certain 
circumstances, your spouse may have community property rights in the 
option.

16.     Can I transfer my options?

       You may not transfer an incentive stock option (except by will 
or the laws of descent) nor may you transfer a non-statutory stock 
option if you are an officer (or director) subject to Section 16(b) 
of the Securities Exchange Act of 1934, as amended. You may transfer 
a non-statutory stock option to a trust for your benefit or the 
benefit of your immediate family.

17.     Can I sell the stock I receive from exercising my option 
right away?

       Generally, yes.  The stock you receive upon exercise of your 
option is registered under the securities laws and freely tradeable 
in most cases.  If you are an officer or director of the Company 
certain restrictions may apply, see Question 3.  If you exercise an 
incentive stock option, an immediate sale may have certain tax 
consequences, see Question 27.  However, if the terms of the option 
permit you to exercise your option before it is vested, see Question 
30, you may not sell shares of stock which the Company still has the 
right to repurchase if your employment is terminated for any reason. 
You should talk to Kathy Panko or Karen Strand if you think this 
applies to you and you wish to sell stock.

18.     How do I sell stock I received under the option?  Do I have 
to pay a commission when I exercise my option or sell the stock I 
received under the option?

       You pay no commission on exercise of options; however, if you 
decide to sell the stock received on exercise you can expect to be 
charged a fee or commission if you use a stock broker.  To sell your 
stock, you must generally take the stock certificate to a stock 
broker who, for a commission, can arrange for its sale. Officers and 
directors are subject to special limitations on the sale of their 
stock.  The Company will not buy or sell, or assist you in selling, 
stock which you have purchased under the Option Plan.

19.     I have heard about cashless exercise programs through 
brokers, how do these work?

       Cashless exercise programs involve the delivery to a broker of 
a copy of your signed and completed option exercise form and your 
irrevocable instructions to the Company to deliver stock to be 
received upon exercise of the option to the broker rather than to 
you.  You can obtain an instruction form for your broker from Kathy 
Panko or Karen Strand.  Under Regulation T the broker can then 
characterize the stock as margin stock, and deliver cash to the 
Company in payment of the exercise price.  The Company delivers the 
stock certificate to the broker.  After the stock is delivered to the 


                                  9
<PAGE>


broker the stock can be maintained as margin stock in an account 
designated by you or sold pursuant to your instructions.  However, 
the Company will not participate in any Regulation T program which 
would cause stock certificates to be delivered to the broker before 
cash for the exercise price has been paid by the broker to the 
Company.

20.     How can I make a gift of stock I receive under the Option 
Plan?

       You may make a gift of stock by delivering the stock 
certificate, with the transfer block on the back filled in, and 
signed and with the signature guaranteed by a bank or stock broker 
(or else by delivering the stock certificate together with an 
"assignment separate from certificate" filled in, signed and the 
signature similarly guaranteed) to the recipient of the gift. The 
recipient may then send the certificate and associated paperwork to 
the Company's transfer agent, Bank of Boston at P.O. Box 1865, 
Boston, Massachusetts 02105-1865, to have the certificate transferred 
to the recipient's name.  If you have a brokerage account, your 
broker will generally be willing to take care of the mechanics of 
transfer.

21.     Does the Company go out on the market to buy the stock which 
I will receive on exercise of my option?

       The shares you will receive upon exercise of your option may 
be newly-issued shares or shares previously reacquired by the 
Company.

22.     Does the Option Plan have any of the same benefits as a 
qualified retirement plan (including a 401(k) plan) and will my 
participation in the Option Plan affect my participation in the 
Company's 401(k) plan?

       The Option Plan is not a qualified retirement plan and 
therefore does not have the same tax deferral benefits.  Your 
participation in the Option Plan does not affect your ability to 
participate in the Company's 401(k) plan.

       The following materials respond to questions you may have 
about the tax consequences of participating in the Option Plan.  You 
should understand, however, that this tax information is not 
complete, nor does it address state or local tax laws or the 
application of laws if you live outside the United States. 
Furthermore, because tax laws and regulations are constantly 
changing, and interpretations of these laws and regulations by the 
courts and tax authorities can change the way the laws and 
regulations apply to you, the information may need to be updated 
after the date of issuance of this prospectus.  Therefore, you should 
consult with an accountant, lawyer or other person competent to give 
tax advice if you have questions relating to the tax consequences of 
participation in, and the sale of shares received under the Option 
Plan.






                                  10
<PAGE>




23.     Do I have to pay tax when I receive a stock option or 
exercise the stock option?  Will the Company withhold the amount of 
taxes due?

       Normally, neither you nor the Company have to pay any tax or 
receive any deductions when you are granted an option under the 
Option Plan.  Whether you will have to pay tax on exercise of an 
option will depend on whether the option is an incentive stock option 
or a non-qualified stock option.

       If you exercise a non-qualified stock option when the market 
price is higher than the exercise price, you generally are required 
to pay tax on the "profit", that is the difference between the 
exercise price and the market price of the stock on the date of 
exercise.  Your profit on the exercise will be characterized as 
ordinary income.

       Generally the Company is required by the IRS to withhold 28% 
of your profit from your wages or to otherwise ensure that this 
amount will be paid to the IRS.  Additional amounts will usually be 
withheld for state taxes.  The Compensation Committee may provide you 
with the option of having shares that would otherwise be delivered to 
you on exercise of an option withheld or delivering shares you 
already hold valued at the withholding amount.

       If you exercise an incentive stock option, unless you are 
subject to the alternative minimum tax (see Question 33), you do not 
have to pay any tax at the time of exercise on the difference between 
the exercise price and the market price of the stock on the date of 
exercise.  You may eventually pay tax on this amount when you sell 
the stock.

24.     How much tax do I have to pay when I sell stock received 
pursuant to the exercise of a non-statutory stock option?

     If you exercised your option when the exercise price was lower 
than the market price, you generally should have paid tax on the 
difference between the two.  If you then sell your stock at a price 
greater than the market price on the date of exercise, you generally 
will have to pay tax on the difference between the selling price and 
the market price at the time of exercise.  Your profit will be 
characterized as short or long-term capital gain depending on whether 
you held the stock for more than one year from the date the option 
was exercised.

     If you exercised your option when the exercise price was lower 
than the market price but you sell the stock at a price lower than 
the market price at the time of exercise, you will be entitled to 
report a capital loss equal to the difference between the sale price 
and the market price at the time of exercise. Your loss will be 
characterized as a long-term or short-term capital loss depending on 
whether you held the stock for more than one year from the date the 
option was exercised.

25.     What is the difference between ordinary income and capital 
gains?

       Long-term capital gains of individuals are subject to a 
maximum marginal federal income tax rate of 28%.  This is in contrast 
to a maximum rate of 39.6% for ordinary income of some individuals.

                                   11
<PAGE>

      Notwithstanding the presence or absence for any individual 
taxpayer of a difference between the rate of tax on capital gains and 
the rate of tax on ordinary income, there are other differences under 
the Internal Revenue Code between capital gains and ordinary income.  
For example, capital gains and losses are "netted" against other capital 
gains and losses and only $3,000 of net capital losses may be deducted 
against ordinary income in any year by any individual taxpayer.

26.     When do I pay tax on stock received pursuant to the exercise 
of an incentive stock option?

       Except for the possible application of the alternative minimum 
tax (see Question 33), you normally pay no tax on the exercise of an 
incentive stock option until you sell or otherwise dispose of the 
stock.

       You should be aware that transfer of legal title to the stock 
received upon exercise of an incentive stock option in a transaction 
that is not a sale may still be taxable as a disposition of the 
stock.  Generally, such transfers include gifts, but do not include a 
transfer into joint ownership with right of survivorship if you 
remain one of the joint owners, a pledge or a transfer by bequest or 
inheritance, exchanges qualifying under certain provisions of the 
Internal Revenue Code regarding tax-free exchanges of stock, or 
certain transfers to a spouse or former spouse incident to a divorce.

27.     How is my profit taxed?  What if I lose money?

       How your profit or loss is characterized will depend on how 
long you held the stock from the date the incentive stock option was 
granted and the date you exercised the option.

       If, before you dispose of the stock, you hold the stock for 
two years or more from the date on which the incentive stock option 
is granted and one year or more from the date on which you exercised 
your option, your gain or loss is characterized as long-term capital 
gain or loss.

       If you dispose of your stock within two years from the date on 
which the option was granted or within one year from the date on 
which you exercised your option, a portion of your profit will be 
characterized as ordinary income and the sale is called a 
"disqualifying disposition."

       The portion of your profit which is characterized as ordinary 
income is equal to the lesser of

       a.   the difference between the market price of the stock on 
the date you exercised the option and the exercise price of the 
option but in no event less than zero, or

       b.   the difference between the sale price and the exercise 
price of the option but in no event less than zero.

     Any profit you make over the amount characterized as ordinary 
income is characterized as capital gain which will be long-term or 
short-term depending on whether the stock was held for more than one 
year from the date of exercise.



                                   12
<PAGE>


       For example, assume you were granted an option on January 1, 1995 
for 10 shares at an exercise price of $8.00 per share.  You exercise the 
option on January 1, 1996 when the market price is $10.00 per share and 
you sell the stock on July 1, 1996 when the market price is $9.00 per 
share for a $10.00 aggregate profit. Because you sold the stock before 
January 1, 1997, the date which is two years after the date of grant and 
one year from the date of exercise, all or a portion of your profit is 
ordinary income. The amount of ordinary income is equal to the lesser of 
(a) $10.00 (market price on date of exercise) - $8.00 (exercise price) = 
$2.00 per share or $20.00 for 10 shares or (b) $9.00 (sale price) - 
$8.00 (exercise price) = $1.00 per share or $10.00 for 10 shares.  All 
of your $10.00 profit will be ordinary income.  If the market price on 
the date of exercise had been $9.00 and the sale price had been $10.00, 
then of your $20.00 profit, $10.00 would be characterized as ordinary 
income and $10.00 would be characterized as short-term capital gain.

       If you lose money on the sale of the stock you will be able to 
report the loss as a capital loss which will be long-term or short-
term depending on whether the stock was held for more than one year 
from the date of exercise.

       Different rules will apply if, under the Internal Revenue Code, 
you are not entitled to report a loss on the sale of your stock if you 
were to lose money on the sale.  For example, if you sell your stock to 
your spouse at a loss, you are not entitled to report the sale as a loss 
and any subsequent tax consequences on the further disposition of the 
stock are determined under the section of the Internal Revenue Code 
which governs such situations.  Other dispositions of stock, described 
in the Internal Revenue Code, may have similar consequences.

28.       Is there any withholding on the exercise of my incentive 
stock option or the sale of the stock acquired on exercise?

       There is no withholding required upon the exercise of an 
incentive stock option.  The Company is required to report to the IRS 
any ordinary income recognized by you as a result of a sale which is a 
disqualifying disposition described in Question 27, if such information 
is available to the Company.  The Company may be required in the future 
to withhold taxes on such ordinary income from your salary.

29.     Do I have to complete any forms after I sell or transfer my 
stock?

       Yes, if you sell or transfer stock received pursuant to an 
incentive stock option within two years after the date the option 
covering the stock was granted to you or within one year after you 
exercise your option, you should complete and deliver to Kathy Panko 
or Karen Strand the disqualifying disposition survey provided to you. 

30.     Are there any special tax rules which apply to me if the Company 
has the right to repurchase my stock after I exercise my option?

        Yes.  Generally, if the Company has the right to repurchase 
your stock after you exercise your option it is because, under the 
terms of your option, you were allowed to exercise all of your 
option, even the unvested portion.  In this situation the Company may 
retain a right to repurchase any shares which are unvested under the 
option until they vest.


                                   13
<PAGE>



       If the Company has the right to repurchase your stock after 
you exercise your option, your stock is subject to what is called a 
"risk of forfeiture." If there is a risk of forfeiture the amount of 
ordinary income you must report and the time at which you must report 
your income may be different than described above.

       The special tax rules applicable to Non-Qualified Stock 
Options and Incentive Stock Options are as follows:

       NON-QUALIFIED STOCK OPTION.

       In the case of stock issued pursuant to a non-qualified stock 
option and subject to a right of repurchase by the Company, you do 
not owe tax on the date of exercise but instead owe tax on the dates(s) 
the risk of forfeiture with respect to the shares disappears, i.e., the 
date the Company no longer has the right to repurchase the stock.

       For example, assume that on April 1, 1994 you are granted an 
option to purchase 20 shares of stock for $8.00 per share. The terms 
of the option indicated that you vest in 10% of the shares on 
December 31, 1996, an additional 15% of the shares on December 31, 
1997, an additional 25% of the shares on December 31, 1998, and an 
additional 50% of the shares on December 31, 1999.  You may exercise 
the option immediately but the Company has the right to repurchase 
all of the stock if you leave the Company before December 31, 1996, 
90% of the stock if you leave the Company before December 31, 1997, 
and 75% of the stock if you leave the Company before December 31, 
1998 and 50% of the stock if you leave the Company before December 
31, 1999.  On February 20, 1995 you exercise your option with respect 
to all of the shares when the market price is $10.00.  Normally you 
would owe tax on $40.00, the difference between the exercise price 
and the market price on the date of exercise.  However, because all 
the shares are subject to a risk of forfeiture you do not calculate 
the tax on February 20.  Assume that on December 31, 1996 the market 
price is $11.00 per share.  On that date a risk of forfeiture 
disappeared with respect to 2 shares.  In other words, the Company no 
longer had the right to repurchase 2 of your 20 shares.  Accordingly, 
with respect to those 2 shares you owe tax on the difference between 
the exercise price and the market price on December 31, or tax on $6.00.

       If the market price of the stock continues to rise after 
December 31, 1996, you will end up paying more ordinary income tax as 
a result of your exercise of the option than you would have if the stock 
you received upon exercise had not been subject to a risk of forfeiture 
and you owed tax only on the difference between the exercise price and 
the market price on the date of exercise.

       If you want to avoid this result you can file what is called a 
Section 83(b) election within 30 days after the exercise of the 
option and report ordinary income equal to the difference, if any, 
between the market price and the exercise price on the date of 
exercise.  When you later sell your shares, any additional gain or 
any loss will be characterized as capital gain or loss, which will be 
long-term or short-term depending on whether the shares are held for 
more than one year from the date you exercised your option.  You 
should be aware, however, that if you file an 83(b) election and you 
subsequently lose the right to own the shares because, for example, 
you leave the Company and the Company repurchases the shares at cost, 
you will not be able to report the amount you paid in taxes as a loss 
on the stock and will not be able to have the taxes refunded.

                                   14
<PAGE>


       INCENTIVE STOCK OPTION.

       If stock you received pursuant to the exercise of an incentive 
stock option is subject to a right of repurchase by the Company and 
you dispose of the stock after the right of repurchase has 
disappeared in a disqualifying disposition (see Question 27) the 
amount of ordinary income you must report is calculated differently. 
In this case, the amount of ordinary income is equal to the lesser of

       a.   the difference, if any, between the exercise price and 
the market price of the stock on the date or dates the risk of 
forfeiture disappears but not less than zero, or

       b.   the profit, if any, on the sale of the stock but not less 
than zero.

       If your profit is more than the amount that must be reported 
as ordinary income, then the remainder of the profit is characterized 
as capital gain which will be long-term or short-term depending on 
whether the stock was held for more than one year from the date of 
sale.

       For example, assume that on January 1, 1994 you received an 
incentive stock option for 20 shares at a price per share of $10.00. 
The terms of the option indicated that you vested in only 25% of the 
shares initially with the remainder of the shares vesting at a rate 
of 25% per quarter.  On February 1, 1994 you exercise the option when 
the stock is worth $10.00 per share. You do not have to pay any tax 
at the time of exercise.  On April l, 1994, when the second 25% of 
the shares vests, the market price is $11.00 per share and on July 1, 
1994, when the third 25% of the remaining shares vests the market 
price is $9.00 per share.  On August 1, 1994, you sell the 15 vested 
shares when the market price is $12.00 per share for a total profit 
of $30.00 (15 X $2.00).  Because you did not hold the stock for more 
than one year, the sale is a disqualifying disposition and you are 
required to recognize ordinary income.

       To calculate the ordinary income, you calculate the difference 
between the exercise price of $10.00 and the market price of the 
stock on the date of exercise, or, if later, the dates the risk of 
forfeiture disappeared.  On the date of exercise there was no spread 
with respect to the first 25% vested installment.  Therefore, you 
recognize no ordinary income with respect to these 5 shares.  On 
April 1 the market price was $11.00 and the risk of forfeiture 
disappeared with respect to 5 shares, so the difference between the 
exercise price and the market price was $1.00 per share or an 
aggregate of $5.00.  On July 1, the market price was $9.00 and the 
risk of forfeiture disappeared with respect to another 5 shares. 
Since the market price was less than the exercise price you do not 
put the negative difference in the calculation.

        The aggregate difference between the exercise price and the 
market prices on the dates the risk of forfeiture lapsed is $5.00, 
which is less than the $20.00 profit made on the 10 shares with 
respect to which there was a risk of forfeiture.  Therefore, $5.00 of 
your $30.00 profit will be treated as ordinary income and $25.00 will 
be short-term capital gain.



                                  15
<PAGE>



       If you lose money on the sale of your stock, the loss will be a 
capital loss and will be long-term or short-term depending on whether 
the stock was held for more than one year from the date of exercise, or, 
if later, the dates the risk of forfeiture disappeared.

        In order to avoid having to calculate the ordinary income in the 
manner discussed above you may make the 83(b) election discussed earlier 
in this question.  Once the election is filed, your ordinary income 
should be calculated in the manner described in Question 27.

Please see Kathy Panko or Karen Strand for further information and the 
form of election if you think you should be filing an 83(b) election.  
Remember that this must be done within 30 days after you exercise your 
option.  Filing an 83(b) election may also affect your alternative 
minimum tax liability, if any (see Question 33).

31.    What are the tax consequences if I use shares I already own to 
pay the exercise price of my non-qualified stock option?

       If you pay the exercise price of your non-qualified stock option 
with shares of the Company which you own immediately prior to the 
exercise, you will have a tax-free exchange of the previously held 
shares of stock for an equivalent number of the shares of stock received 
under the option.  If you receive additional shares in the exchange, you 
will pay taxes on ordinary income equal to the difference between the 
market value on the date of exercise of such additional shares and the 
amount of cash, if any, you paid upon exercise.

       The tax basis and capital-gain holding period of the shares 
received under the option in the tax-free exchange will be the same as 
the tax basis and holding period of the shares used to pay the exercise 
price.  The tax basis of the additional shares you receive will equal 
the amount of ordinary income you had to report and the amount of any 
cash paid on exercise, and your holding period for the additional shares 
will begin on the date of exercise.

       For example, assume that on January 1, 1996 you bought 10 shares 
of stock on the open market when the market price was $6.00 per share.  
The price of the stock goes up and on January 1, 1997, when the market 
price is $10.00 per share, you exercise a non-qualified stock option to 
purchase 20 shares at an exercise price of $9.00 per share for an 
aggregate exercise price of $180.00.  Using all of your previously 
existing shares to pay $100.00 of the exercise price (10 x $10.00 market 
price), you pay $80.00 cash for the remainder of the exercise price.  
Accordingly, on the date of exercise you are deemed to have a tax-free 
exchange of the 10 previously held shares for 10 of the new shares.  You 
will also recognize ordinary income equal to the market price of the 10 
additional shares you received, $100.00, minus the amount of cash you 
paid on exercise, $80.00, or $20.00.

       If you sell the 10 shares which you received in the tax-free 
exchange for $11.00 per share on March 1, 1997, you will recognize a 
$5.00 per share profit, which will be a long-term capital gains because 
you are allowed to add the period which you held the original 10 shares 
to the period you held the new 10 shares. If on the same day you also 
sell the 10 additional shares, you will have a taxable profit equal to 
$110.00 minus the amount of cash you paid, $80.00, and the amount of 
income you recognized, $20.00, or a taxable profit of $10.00.  This 
profit will be characterized as a short-term capital gain because you 
held the stock for only two months.

                                   16
<PAGE>


32.     What are the tax consequences if I use shares I already own 
to pay the exercise price of incentive stock options?

       Under proposed regulations, if you pay the exercise price of 
an incentive stock option, in whole or in part, with shares you 
already own immediately prior to the exercise, you are deemed to have 
made a tax-free exchange of the previously-held shares for an 
equivalent number of shares received under the option.  For example, 
assume you purchased 10 shares on the open market for $6.00 per share 
on January 1, 1996.  On February 1, 1997 you exercise an incentive 
stock option covering 20 shares at $10.00 per share using 10 of your 
already owned shares as payment of $100.00 of the purchase price and 
delivering $100.00 in cash in payment of the exercise price of the 
additional shares.  You are deemed to have made a tax free exchange 
of 10 of your already owned shares for the 10 new shares received on 
exercise.  You recognize no profit at this point, even though you 
have used shares you bought at $6.00 per share to buy the same number 
of shares with a value of $10.00 per share.

       However, ordinary income could be recognized (see Question 27) 
if the already owned shares were acquired upon exercise of an 
incentive stock option or under an employee stock purchase plan as 
defined in Section 423 of the Internal Revenue Code and the exchange 
were treated as a disposition.  The exchange will be treated
as a disposition if the already owned shares are exchanged within two 
years of the grant of option relating to the already owned shares or 
within one year after the exercise of such option.  The tax basis, 
holding periods and consequences of a subsequent disposition of shares 
received upon exercise will depend on whether the shares disposed of
are equivalent shares or additional shares received at the time of 
exercise ("additional shares").

       For purposes of calculating any capital gain or loss upon a 
subsequent taxable disposition, your basis in the equivalent shares 
will be equal to your basis in the shares surrendered plus any 
ordinary income recognized by reason of the exchange, and the holding 
period of the surrendered shares will carryover to the equivalent 
shares.

       If you use only shares you already own to pay the exercise 
price, your basis in any additional shares will be zero for purposes 
of calculating any capital gain upon a later disposition.  For 
purposes of calculating any ordinary income upon a disqualifying 
disposition of the additional shares the amount treated as having 
been paid for the additional shares will be zero.  To the extent you 
use other forms of payment, your basis should be equal to the amount 
of the other form of payment, and it will reduce the amount of 
ordinary income upon a disqualifying disposition by the same amount. 
The holding period for the additional shares will begin on the date 
of exercise for all purposes.  In the event of a disqualifying 
disposition of shares acquired upon such an exercise of an incentive 
stock option with stock, the shares with the lowest basis (i.e., the 
additional shares and not the equivalent shares) will be treated as 
having been disposed of first.






                                   17
<PAGE>



33.     What are the tax consequences of my exercise of options if I 
am subject to the alternative minimum tax?

       The alternative minimum tax is a separately computed tax equal 
to a marginal rate of up to 28% of alternative minimum taxable income 
that is imposed only if and to the extent you would pay more tax if 
your taxes are computed pursuant to the alternative minimum tax rules 
than the tax you would pay if computed in the regular manner.  The 
alternative minimum tax takes into account what are called tax 
preference items and other adjustments that are not taken into 
account when calculating taxes in the regular manner.  One of the 
adjustments is the inclusion in taxable income of the difference 
between the exercise price of an incentive stock option and the 
market price of the stock option on the date of exercise, if that 
amount constitutes a profit.  When you sell the stock, you are 
allowed, for purposes of calculating your alternative minimum tax in 
the year of sale, to decrease the profit by the adjustment amount 
previously included in the alternative minimum taxable income.

     If you are subject to a risk of forfeiture, see Question 30, the 
amount of the adjustment will be calculated using market prices on 
the dates the forfeiture lapses rather than the date you exercise the 
option, and the adjustment must be made in the year in which the risk 
of forfeiture disappears.  It may be possible, however, to make a 
valid election under Section 83(b) within 30 days of the date of 
exercise to have the market price on the date of exercise be the 
price used in the calculation of your alternative minimum tax and to 
make the adjustment in the year of exercise.  However, if a Section 
83(b) election is made, there may be implications for purposes of 
calculating ordinary income, if any, in the event of a disqualifying 
disposition.

34.     What happens to my option or stock issued under the Option 
Plan in the event Genentech is acquired by a person other than Roche?

        The Option Plan provides that, in the event of a "corporate 
transaction", each option outstanding under the Option Plan will be 
automatically accelerated so that the option becomes fully 
exercisable with respect to the total number of shares subject to 
such option.  However, an option will not be accelerated if, as part 
of the corporate transaction, the option is either assumed by the 
successor Company or replaced with a comparable option or the option 
is replaced by a comparable cash incentive program or such 
acceleration is otherwise limited by the terms of the option grant. 
Corporate transactions include a merger or acquisition in which 
Genentech does not survive, a sale or other disposition of all or 
substantially all of the assets of Genentech or any reverse merger in 
which Genentech survives but in which 50% or more of Genentech's 
outstanding voting stock held by persons other than Roche or its 
affiliates is transferred to new holders.

        In addition, the Option Plan sets forth provisions applicable 
upon a "change in control".  Generally speaking, a change in control 
is (i) the acquisition by a person, other than Genentech or a Company 
controlling Genentech, of securities of Genentech representing 30% or 
more of the voting power of Genentech's then outstanding securities 
pursuant to a transaction not approved by the Board or (ii) a change 
in composition of the Board within any 36 month period so that the 
majority of the Board is not made up of members who either have been 
members of the Board since the beginning of the period, or have been 

                                  18
<PAGE>


elected by at least a majority of the members who were members 
continuously during the period.  Upon such a change in control, each 
option will be automatically accelerated immediately prior to the 
change in control so that the option will be exercisable for all or 
any portion of the shares subject to the option, at the election of 
the optionee, unless limitations included in the option at the time 
of grant preclude such treatment.

       The Option Plan provides that exercise by Roche of its rights 
to designate nominees to the Board of Directors constituted a change 
in control.  The Committee has authority under the Option Plan to 
impose additional limitations at the date of grant with respect to 
the acceleration of options and vesting upon corporate transactions 
and changes in control.

35.     What happens if the vesting of my options accelerates upon a 
change of control?

     In the event that there is a change in control of the Company, 
payments received by certain optionees that are contingent upon the 
change in control may constitute "parachute payments." If, by reason 
of such change in control, the exercisability of outstanding options 
is accelerated, the value of the acceleration is added to other 
contingent payments, if any, in determining whether the optionee has 
received "excess parachute payments."  As used herein, the terms 
"parachute payments" and "excess parachute payments" shall have the 
meanings given to them in Section 280G of the Internal Revenue Code. In 
general, if an optionee receives excess parachute payments, an excise 
tax equal to 20% of the amount of such excess parachute payments is 
imposed on the optionee, and the Company does not receive a deduction 
for such amount.

        B.   Automatic Grant Program

36.     Are non-employee directors eligible to receive options under 
the Option Plan?

       Yes.  Under the Automatic Grant Program portion of the Option 
Plan, on April 30, l995, each individual who is a non-employee member of 
the Board will be automatically granted a non-statutory option to 
purchase 15,000 shares of Redeemable Common Stock.  Each non-employee 
member of the Board who is first elected to the position after April 30, 
l995 will be automatically granted a non-statutory option for the same 
number of shares.  All options granted under the Automatic Grant Program 
will have an exercise price equal to 100% of the closing selling price 
on the trading day prior to the grant date.  Each option granted under 
the Automatic Grant Program will vest in increments of 5,000 shares on 
each of the first, second and third anniversaries of the grant date and 
be exercisable until the expiration or earlier termination of the option 
term.  Such options will have a term of ten years, and will not be 
assignable or transferable otherwise than by will or by the laws of 
decent and distribution.  Each employee member of the Board who becomes 
a non-employee member of the Board following April 30, l995 will be 
automatically granted such an option immediately upon the date of his or 
her change of status.  After April 30, 1995, options will no longer be 
granted to non-employee board members under the Company's 1990 Stock 
Option/Stock Incentive Plan.



                                   19
<PAGE>



       If a holder of an option issued under the Automatic Grant 
Program ceases to be a member of the Board for a reason other than 
the holder's death, the option will remain exercisable for a period 
ending on the earlier of (i) the expiration of the three month period 
following the cessation of membership on the Board or (ii) the 
expiration of the option.  If a holder of an option issued under the 
Automatic Grant Program ceases to be a member of the Board due to the 
holder's death, the option may be exercised by the holder's estate or 
transferee pursuant to a will or applicable law for a period ending 
on the earlier of (i) the expiration of the 12 month period following 
the date of the optionee's death or (ii) the expiration of the 
option.

       In general, in the event of a corporate transaction, each 
option shall automatically accelerate and become exercisable for any 
or all of the shares subject to the option immediately prior to the 
specified effective date for such corporate transaction.  Upon the 
consummation of a corporate transaction, all options to the extent 
not exercised will terminate.

       In general, in the event of a change in control, all options 
will automatically accelerate and become fully exercisable.  In 
addition, each option that has been outstanding for at least six 
months may be surrendered after the change in control for a cash 
payment from the Company in an amount equal to the excess of the fair 
market value of the shares of Redeemable Common Stock subject to such 
option over the aggregate option price payable for such shares.

C.      Miscellaneous

37.     What are some of the other features of the Option Plan?

       (i) The number of shares subject to the Option Plan is 
4,500,000.  Shares subject to options granted under the Option Plan 
which expire or are canceled or terminated for any reason prior to 
exercise shall be available for future option grants under the Option 
Plan; however, shares repurchased by the Company pursuant to 
repurchase rights shall not be available for subsequent issuance;

       (ii) The number of shares available for issuance under the 
Option Plan, the maximum number of shares that may be issued to an 
employee,  the number of shares that may be issued to non-employee 
directors, the number of shares and the exercise price of each 
outstanding option  under the Option Plan shall all be appropriately 
adjusted by the Compensation Committee to reflect any stock dividend, 
stock split, combination, exchange or other change in the Company's 
capital structure, including changes due to a Corporate Transaction, 
subject to the terms of the Option Plan regarding Corporate 
Transactions (see Question 34)

       (iii) The Compensation Committee may, with the consent of 
option holders, cancel any or all outstanding options granted under 
the Option Plan and grant in substitution new options under the 
Option Plan.

       (iv) The cash proceeds received upon exercise of options 
granted under the Option Plan will be used for general corporate 
purposes;


                                  20
<PAGE>



       (v) The implementation of the Option Plan and the granting of 
any stock option shall be subject to the Company's procurement of all 
approvals and permits required by applicable regulatory authorities;

       (vi) Neither the establishment of the Option Plan, any term 
thereunder nor any action by the Compensation Committee shall be 
construed so as to grant any individual the right to remain employed 
by the Company or its parent or subsidiaries for any period and the 
Company (and any parent or subsidiaries employing such person) may 
terminate any employee at any time and for any reason, with or 
without cause; and

       (vii) Nothing in the Option Plan shall limit the Company's 
exercise of all of its rights and powers, including its right to 
grant options outside of the Option Plan.


                     PLAN OF DISTRIBUTION

       For a discussion of the factors relating to the grant and 
exercise of stock options under the Option Plan please refer to the 
information contained under the heading "The 1994 Stock Option Plan" 
above.  Sales of Redeemable Common Stock under the Option Plan will 
be made directly by the Company upon exercise of options granted 
under the Option Plan without the use of any underwriters or dealers.

              DESCRIPTION OF THE REDEEMABLE COMMON STOCK

       Set forth below is a description of the terms of the 
Redeemable Common Stock.

Voting Rights

       The holders of Redeemable Common Stock are, on all matters 
submitted to a vote of the stockholders of the corporation, entitled 
to one vote per share, voting as a single class with the shares of 
Common Stock currently held by Roche (the "Shares") unless otherwise 
provided for in the Certificate of Incorporation or required by 
applicable law.  According to a Schedule 13D filing of Roche dated April 
27, 1994, on that date Roche owned 67,133,409 shares of Common Stock and 
7,724,700 shares of Redeemable Common Stock.

Dividends; Reclassifications; Mergers

       Holders of Redeemable Common Stock are entitled to receive 
such dividends and other distributions in cash or property as may be 
declared thereon by the Board of Directors from time to time out of 
assets or funds of Genentech legally available therefor, and shall 
share equally with the Shares on a per share basis in all such 
dividends and other distributions.  In the case of dividends or other 
distributions payable in stock of Genentech other than Preferred 
Stock, including distributions pursuant to stock splits or divisions 
of stock of Genentech other than Preferred Stock which occur after 
the initial issuance of shares of Redeemable Common Stock by 
Genentech, only Shares shall be paid or distributed with respect to 
Shares and only shares of Redeemable Common Stock in an amount per 
share equal to the amount per share paid or distributed with respect 
to Shares shall be paid or distributed with respect to Redeemable 
Common Stock. In the case of any combination or reclassification of 
the Redeemable Common Stock or the Shares, the Shares or the 

                                   21
<PAGE>


Redeemable Common Stock, as the case may be, shall also be combined 
or reclassified so that the number of Shares outstanding immediately 
following such combination or reclassification shall bear the same 
relationship to the number of Shares outstanding immediately prior to 
such combination or reclassification as the number of shares of 
Redeemable Common Stock outstanding immediately following such 
combination or reclassification bears to the number of shares of 
Redeemable Common Stock outstanding immediately prior to such 
combination or reclassification.

       In case Genentech enters into any consolidation, merger, 
combination or other transaction in which the Shares are exchanged 
for or changed into other stock or securities, cash and/or any other 
property, then in any such case each share of Redeemable Common Stock 
shall at the same time be similarly exchanged or changed into an 
amount per share, equal to the aggregate amount of stock, securities, 
cash and/or any other property (payable in kind), as the case may be, 
into which or for which each Share is changed or exchanged; provided 
that any such stock may be made redeemable on terms no less favorable 
to the holder thereof than the terms upon which the Redeemable Common 
Stock is redeemable.

Liquidation

       Upon any liquidation, dissolution or winding up of Genentech, 
no distribution shall be made (1) to the holders of Shares unless, 
prior thereto, the holders of shares of Redeemable Common Stock shall 
have received $.01 per share, plus an amount equal to declared and 
unpaid dividends and distributions thereon to the date of such 
payment; provided that the holders of shares of Redeemable Common 
Stock shall be entitled to receive an aggregate amount per share 
equal to the aggregate amount to be distributed per share to holders 
of Shares, or (2) to the holders of stock ranking on a parity (either 
as to dividends or upon liquidation, dissolution or winding up) with 
the Redeemable Common Stock, except distributions made ratably on the 
Redeemable Common Stock and all such other parity stock in proportion 
to the total amounts to which the holders of all such shares are 
entitled upon such liquidation, dissolution or winding up.

Redemption

       The Redeemable Common Stock may be redeemed, in whole but not 
in part, at the option of Genentech, during the periods and at the 
prices and upon the terms and conditions described below.

       The redemption price for any Redemption Date during the 
periods set forth below shall be the price set forth opposite such 
period in the following table, adjusted as set forth below:

Period Price

       
January 1, 1995 to March 31, 1995            $58.75
April 1, 1995 to June 30, 1995               $60.00

       The foregoing redemption prices are subject to appropriate 
adjustment in the case of any dividend payable in shares of 
Redeemable Common Stock, or any subdivision or combination of the 



                                  22
<PAGE>


Redeemable Common Stock.  In addition, if Genentech at any time after 
the initial issuance of any Redeemable Common Stock declares or pays any 
dividend on Redeemable Common Stock in cash, securities or other 
property other than Redeemable Common Stock, the redemption prices in 
effect for each period after such event will each be reduced by the per 
share value of such dividend (as determined in good faith by the Board 
of Directors, in the case of noncash dividends) multiplied by a 
fraction, the numerator of which equals the redemption price which would 
otherwise be in effect for such period and the denominator of which 
equals the redemption price in effect at the time of such event; 
provided that such adjustment will not be made with respect to cash 
dividends determined by the majority of the Board of Directors to be in 
the ordinary course and approved by the majority of the directors 
nominated by Roche.

       Notice of any proposed redemption of the Redeemable Common Stock 
will be given by mail to the holders of record, not more than 30 nor 
less than 10 days prior to the date fixed for redemption.  On or prior 
to the date such notice is first sent or given, Genentech will deposit 
or cause to be deposited the aggregate of the redemption price (together 
with accrued and unpaid dividends to such redemption date) of the shares 
to be redeemed with a bank or trust Company (the "Depositary"), 
designated in the notice of such redemption, in trust for payment to the 
holders of the shares, and deliver irrevocable written instructions 
authorizing the Depositary to apply such deposit solely to the 
redemption of the shares to be redeemed.  The amount of funds required 
to be deposited pursuant to the foregoing sentence will be reduced by 
the aggregate redemption price of any shares of Redeemable Common Stock 
held by Roche deposited in lieu of such funds.  Notice of redemption 
having been duly given, or the Depositary having been irrevocably 
authorized by Genentech to give said notice, and the redemption price 
(together with accrued and unpaid dividends to such redemption date) of 
the shares to be redeemed having been deposited, all as aforesaid, then 
all shares of Redeemable Common Stock with respect to which such deposit 
shall have been made will forthwith, whether or not the date fixed for 
such redemption shall have occurred or the certificates for such shares 
shall have been surrendered for cancellation, be deemed no longer to be 
outstanding for any purpose, and all rights with respect to such shares 
will thereupon cease and terminate, except the right of the holders of 
such shares to receive, out of such deposit in trust, on the Redemption 
Date the redemption price (together with accrued and unpaid dividends to 
such redemption date) to which they are entitled, without interest.  No 
shares of Redeemable Common Stock will be issued after the Redemption 
Date.

       An agreement provides that Genentech will effect the redemption 
of the Redeemable Common Stock upon the request of Roche, and will not 
effect such redemption absent such request.

Conversion

       Each share of Redeemable Common Stock outstanding at the close of 
business on June 30, 1995 or, if earlier, the thirtieth day after the 
sale by Roche or any of its affiliates of any Shares to any person other 
than Roche or any of its affiliates (the "Conversion Date") will, unless 
previously called for redemption on or prior to such date, automatically 
be converted into one Share.  Other than the right of the Company to 
redeem the Redeemable Common Stock as set forth in DESCRIPTION OF THE 
REDEEMABLE COMMON STOCK, Redemption, there is no difference between the 
Redeemable Common Stock and the Common Stock of the Company.

                                   23
<PAGE>


       Notice of the Conversion Date shall be given by mail to the 
holders of record of the shares of Redeemable Common Stock, not more 
than 30 nor less than 10 days prior to the Conversion Date. Upon request 
of any holder, Genentech will issue and deliver to the holder as 
promptly as practicable after the Conversion Date a replacement 
certificate for the number of Shares issuable upon conversion of such 
Redeemable Common Stock.  No shares of Redeemable Common Stock will be 
issued after the Conversion Date.

       Genentech will provide, free from preemptive rights, out of its 
authorized but unissued Shares, or out of Shares held in its treasury, 
sufficient Shares to provide for the conversion of the Redeemable Common 
Stock of all issued and outstanding shares of Redeemable Common Stock on 
the Conversion Date.  The amendment will provide that all Shares which 
may be issued upon conversion of Redeemable Common Stock will upon issue 
be fully paid and nonassessable by Genentech and free from all taxes, 
liens and charges with respect to the issue thereof.  The amendment will 
further provide that, if on the Conversion Date the Redeemable Common 
Stock shall be listed on the NYSE or on any other national securities 
exchange or the NASDAQ National Market System, Genentech will, if 
permitted by the rules of such exchange, seek to list on each such 
exchange or the NASDAQ National Market System, as the case may be, all 
Shares issuable upon conversion of the Redeemable Common Stock.

Legend

       Each certificate representing shares of Redeemable Common 
Stock will bear the following legend:

       "The shares of Redeemable Common Stock represented hereby are 
subject to (i) redemption at the option of the corporation during the 
periods, at the prices and on the terms and conditions specified in the 
corporation's certificate of incorporation and (ii) conversion into 
Common Stock, par value $.02, of the corporation on the date specified, 
and upon the terms and conditions set forth in, such certificate of 
incorporation.  After redemption the shares represented by this 
certificate shall cease to be outstanding for all purposes and the 
holder hereof shall be entitled to receive only the redemption price of 
such shares, without interest.  After conversion this certificate shall 
represent the shares of Common Stock into which the shares of Redeemable 
Common Stock represented hereby shall have been converted, and this 
certificate may be exchanged for a new certificate representing such 
shares of Common Stock."

Class Vote

       In addition to any affirmative vote required by law or the 
Certificate of Incorporation, any amendment of the provisions of Article 
Third of the Certificate of Incorporation will require the affirmative 
vote of the holders of a majority of the Shares entitled to vote and of 
the holders of a majority of the shares of Redeemable Common Stock 
entitled to vote, each voting separately as a class.


                           LEGAL MATTERS

       The validity of the Redeemable Common Stock offered hereby 
will be passed upon by John P. McLaughlin, Senior Vice President, 
Secretary and General Counsel of the Company.  Mr. McLaughlin 
receives the compensation and owns the securities described in the 
Company's Annual Reports on Form 10-K which are incorporated herein.

                                  24
<PAGE>

                              EXPERTS

       The consolidated financial statements of Genentech, Inc., 
incorporated by reference in the Company's Annual Report (Form 10-K) 
for the year ended December 31,     1994, have been audited by Ernst & 
Young LLP,      independent auditors, as set forth in their report 
thereon included therein and incorporated herein by reference.  Such 
consolidated financial statements are, and audited financial 
statements to be included in subsequently filed documents will be, 
incorporated herein in reliance upon the reports of     Ernst & Young 
LLP      pertaining to such financial statements are (to the extent 
covered by consents filed with the Securities and Exchange Commission) 
given upon the authority of such firm as experts in accounting and 
auditing.

       
MATERIAL CHANGES

       As of the date of this Prospectus, no material changes in the 
Company's affairs, which have not been described in a report on Form 
10-Q, 10-K or 8-K filed under the Exchange Act, have occurred since the 
end of the latest fiscal year for which certified financial statements 
were included in the latest annual report to shareholders except as 
described below:

       
FDA INVESTIGATION:

In September, 1994 the United States Food and Drug Administration (the 
FDA) initiated an investigation into Genentechs promotional practices 
in connection with its products Protropin (registered trademark), 
Activase (registered trademark), and Pulmozyme (registered trademark).  
Genenetech believes that its promotional policies and practices for such 
products comply with the FDAs regulations and Genentech is cooperating 
with the FDA in its investigation.  Genentech does not believe that the 
FDAs investigation will have a material impact on the Company.
























                                  25
<PAGE>



                DISCLOSURE OF COMMISSION POSITION ON
             INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

       Section 145 of the General Corporation Law of the State of 
Delaware (the "DGCL") provides, in summary, that directors and 
officers of Delaware corporations are entitled, under certain 
circumstances, to be indemnified against all expenses and liabilities 
(including attorneys' fees) incurred by them as a result of suits 
brought against them in their capacity as a director or officer, if 
they acted in good faith and in a manner they reasonably believed to 
be in or not opposed to the best interests of the corporation, and 
with respect to any criminal action or proceeding, if they had no 
reasonable cause to believe their conduct was unlawful; provided, 
that no indemnification may be made against expenses in respect of 
any claim, issue or matter as to which they shall have been adjudged 
to be liable to the corporation, unless and only to the extent that 
the court in which such action or suit was brought shall determine 
upon application that, despite the adjudication of liability but in 
view of all the circumstances of the case, they are fairly and 
reasonably entitled to indemnity for such expenses which the court 
shall deem proper.  Any such indemnification may be made by the 
corporation only as authorized in each specific case upon a 
determination by the stockholders or disinterested directors that 
indemnification is proper because the indemnitee has met the 
applicable standard of conduct.

       Article SEVENTH of Genentech's Certificate of Incorporation 
("Article SEVENTH") provides that a director of Genentech is not 
personally liable to the corporation or its shareholders for monetary 
damages for breach of fiduciary duty as a director except for 
liability (i) for any breach of the director's duty of loyalty to the 
corporation or its shareholders, (ii) for acts or omissions not in 
good faith or which involve intentional misconduct or a knowing 
violation of law, (iii) for paying a dividend or approving a stock 
repurchase in violation of Section 174 of the DGCL or (iv) for any 
transaction from which the director derived an improper personal 
benefit.

       Article SEVENTH also provides that directors, officers and 
other individuals will be indemnified by Genentech to the full extent 
permitted by law and shall not be exclusive of any other right which 
any person may otherwise have or acquire.  It provides that each 
person who was or is made a party to or is involved in, any action, 
suit or proceeding by reason of the fact that he is or was a 
director, officer, employee or agent of Genentech (or is or was 
serving at the request of Genentech as a director, officer, employee 
or agent for another entity) while serving in such capacity shall be 
indemnified and held harmless by Genentech, to the full extent 
authorized by the DGCL, as in effect (or, to the extent 
indemnification is broadened, as it may be amended), against all 
expense, liability or loss (including attorneys' fees, judgments, 
fines, ERISA excise taxes or penalties and amounts to be paid in 
settlement) reasonably incurred by such person in connection 
therewith.  It allows such indemnified persons to bring suit against 
Genentech to recover unpaid amounts claimed thereunder, and if such 
suit is successful, the expense of bringing such suit shall be 
reimbursed by Genentech.  It further provides that while it is a 
defense to such a suit that the person claiming indemnification has 
not met the applicable standards of conduct making indemnification 


                                 26
<PAGE>


permissible under Delaware law, the burden of proving the defense 
shall be on Genentech and neither the failure of Genentech's Board of 
Directors to have made a determination that indemnification is 
proper, nor an actual determination by Genentech that the claimant 
has not met the applicable standard of conduct, shall be a defense to 
the action or create a presumption that the claimant has not met the 
applicable standard of conduct.

       Genentech's Certificate of Incorporation and By-laws provide 
that Genentech may maintain insurance, at its expense, to protect 
itself and any of its officers, employees or agents against any 
expense, liability or loss, whether or not Genentech would have the 
power to indemnify such person against such expense, liability or 
loss under Delaware law.  Genentech maintains such insurance for such 
purposes.

       Insofar as indemnification for liabilities arising under the 
Securities Act of 1933 may be permitted to directors, officers or 
persons controlling the registrant pursuant to the foregoing 
provisions, the registrant has been informed that in the opinion of 
the Securities and Exchange Commission such indemnification is 
against public policy as expressed in the Act and is therefore 
unenforceable.





































                                   27
<PAGE>



                              PART II

                 INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution

       The following table sets forth all expenses payable by the 
Company in connection with the issuance and distribution of the 
Redeemable Common Stock being registered.  All the amounts shown are 
estimates except for the registration fee.

       Registration fee                              $75,065.00

       Blue Sky fees and expenses                        $ 0.00

       Stock Exchange Listing Fees                   $ 9,000.00

       Legal fees and expenses                            $0.00

       Accounting fees and expenses                    $7,000.00     

             Total                                    $91,065.00     

Item 15.  Indemnification of Directors and Officers

       Section 145 of the General Corporation Law of the State of 
Delaware (the "DGCL") provides, in summary, that directors and officers 
of Delaware corporations are entitled, under certain circumstances, to 
be indemnified against all expenses and liabilities (including 
attorneys' fees) incurred by them as a result of suits brought against 
them in their capacity as a director or officer, if they acted in good 
faith and in a manner they reasonably believed to be in or not opposed 
to the best interests of the corporation, and with respect to any 
criminal action or proceeding, if they had no reasonable cause to 
believe their conduct was unlawful; provided, that no indemnification 
may be made against expenses in respect of any claim, issue or matter as
to which they shall have been adjudged to be liable to the corporation,
unless and only to the extent that the court in which such action or 
suit was brought shall determine upon application that, despite the 
adjudication of liability but in view of all the circumstances of the 
case, they are fairly and reasonably entitled to indemnity for such 
expenses which the court shall deem proper.  Any such indemnification 
may be made by the corporation only as authorized in each specific case 
upon a determination by the stockholders or disinterested directors that
indemnification is proper because the indemnitee has met the applicable
standard of conduct.

       Article Seventh of Genentech's Certificate of Incorporation 
("Article Seventh") provides that a director of Genentech is not 
personally liable to the corporation or its shareholders for monetary 
damages for breach of fiduciary duty as a director except for liability 
(i) for any breach of the director's duty of loyalty to the corporation 
or its shareholders, (ii) for acts of omissions not in good faith or 
which involve intentional misconduct or a knowing violation of law, 
(iii) for paying a dividend or approving a stock repurchase in violation 
of Section 174 of the DGCL or (iv) for any transaction from which the 
director derived an improper personal benefit.


                                II - 1


<PAGE>


       Article Seventh also provides that directors, officers and 
other individuals will be indemnified by Genentech to the full extent 
permitted by law and shall not be exclusive of any other right which 
any person may otherwise have or acquire.  It provides that each 
person who was or is made a party to or is involved in, any action, 
suit or proceeding by reason of the fact that he is or was a 
director, officer, employee or agent of Genentech (or is or was 
serving at the request of Genentech as a director, officer, employee 
or agent for another entity) while serving in such capacity shall be 
indemnified and held harmless by Genentech, to the full extent 
authorized by the DGCL, as in effect (or, to the extent 
indemnification is broadened, as it may be amended), against all 
expense, liability or loss (including attorneys' fees, judgments, 
fines, ERISA excise taxes or penalties and amounts to be paid in 
settlement) reasonably incurred by such person in connection 
therewith.  It allows such indemnified persons to bring suit against 
Genentech to recover unpaid amounts claimed thereunder, and if such 
suit is successful, the expense of bringing such suit shall be 
reimbursed by Genentech.  It further provides that while it is a 
defense to such a suit that the person claiming indemnification has 
not met the applicable standards of conduct making indemnification 
permissible under Delaware law, the burden of proving the defense 
shall be on Genentech and neither the failure of Genentech's Board of 
Directors to have made a determination that indemnification is 
proper, nor an actual determination by Genentech that the claimant 
has not met the applicable standard of conduct, shall be a defense to 
the action or create a presumption that the claimant has not met the 
applicable standard of conduct.

       Genentech's Certificate of Incorporation and By-laws provide 
that Genentech may maintain insurance, at its expense, to protect 
itself and any of its officers, employees or agents against any 
expense, liability or loss, whether or not Genentech would have the 
power to indemnify such person against such expense, liability or 
loss under Delaware law.  Genentech maintains such insurance for such 
purposes.

Item 16.   Exhibits

Exhibit Number                           Description

4.1          Amended Certificate of Incorporation of the Company.(1)

4.2          Restated By-laws of the Company.(2)

5.1          Opinion of counsel as to the legality of the securities
             being registered. (3)
   
23.1         Consent of Ernst & Young LLP, independent auditors.(5)    

23.2         Consent of Counsel. (3)

24.1         Power of Attorney. (3)

99.1         1994 Stock Option Plan. (4)




                                   II - 2


<PAGE>


(1)  Filed as an exhibit to Registrant's Registration Statement on 
Form S-4 dated May 2, 1990, and incorporated herein by reference.

(2)  Filed as an exhibit to the Registrant's Annual Report on Form 
10-K for the year ended December 31, 1990, and incorporated herein by 
reference.

(3) Previously filed as an Exhibit to the Registration Statement on Form 
S-3 filed with the Commission on June 14, 1994. 

(4) Filed as an exhibit to the Registrant's Annual Report on Form 
10-K for the year ended December 31, 1993, and incorporated herein by 
reference.
   
(5) Filed with this document.     


Item 17.     Undertakings

      A.     Rule 415 Offering

      The undersigned registrant hereby undertakes:

       (1)  To file, during any period in which offers are being 
made, a post-effective amendment to this registration statement:

            (a) To include any prospectus required by Section 
10(a)(3) of the Securities Act of 1933;

            (b) To reflect in the prospectus any facts or events 
arising after the effective date of the registration statement (or 
the most recent post-effective amendment thereof) which, individually 
or in the aggregate, represent a fundamental change in the 
information set forth in the registration statement;

             (c) To include any material information with respect to 
the plan of distribution not previously disclosed in this 
registration statement or any material change to such information in 
the registration statement;

Provided, however, that paragraphs A(1)(a) and A(1)(b) do not 
apply if the information required to be included in a post-effective 
amendment by those paragraphs is contained in periodic reports filed 
by the registrant pursuant to Section 13 or Section 15(d) of the 
Securities Exchange Act of 1934 that are incorporated by reference in 
this registration statement.

       (2)  That, for the purpose of determining any liability under 
the Securities Act of 1933, each such post-effective amendment shall 
be deemed to be a new registration statement relating to the 
securities offered therein, and the offering of such securities at 
that time shall be deemed to be the initial bona fide offering 
thereof.

       (3)  To remove from registration by means of a post-effective 
amendment any of the securities being registered which remain unsold 
at the termination of the offering.

       B.  Filings Incorporating Subsequent Exchange Act Documents by 
Reference

                               II - 3
<PAGE>


       The undersigned registrant hereby undertakes that, for 
purposes of determining any liability under the Securities Act of 
1933, each filing of the registrant's annual report pursuant to 
Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 
that is incorporated by reference in the registration statement shall 
be deemed to be a new registration statement relating to the 
securities offered therein, and the offering of such securities at 
that time shall be deemed to be the initial bona fide offering 
thereof.

     C.     Incorporated Annual and Quarterly Reports

            The undersigned registrant hereby undertakes to deliver 
or cause to be delivered with the prospectus, to each person to whom 
the prospectus is sent or given, the latest annual report to security 
holders that is incorporated by reference in the prospectus and 
furnished pursuant to and meeting the requirements of Rule 14a-3 or 
Rule 14c-3 under the Securities Exchange Act of 1934; and, where 
interim financial information required to be presented by Article 3 
or Regulation S-X is not set forth in the prospectus, to deliver, or 
cause to be delivered to each person to whom the prospectus is sent 
or given, the latest quarterly report that is specifically 
incorporated by reference in the prospectus to provide such interim 
financial information.

































                                  II - 4



<PAGE>



     D.    Acceleration of Effectiveness

            Insofar as indemnification for liabilities arising under 
the Securities Act of 1933 may be permitted to directors, officers 
and controlling persons of the Company pursuant to the foregoing 
provisions, or otherwise, the Company has been advised that in the 
opinion of the Securities and Exchange Commission such 
indemnification is against public policy as expressed in the 
Securities Act, and is, therefore, unenforceable.  In the event that 
a claim for indemnification against such liabilities (other than the 
payment by the Company of expenses incurred or paid by a director, 
officer or controlling person of the Company in the successful 
defense of any action, suit or proceeding) is asserted by such 
director, officer or controlling person in connection with the 
securities being registered, the Company will, unless in the opinion 
of its counsel the matter has been settled by controlling precedent, 
submit to a court of appropriate jurisdiction the question whether 
such indemnification by it is against public policy as expressed in 
the Securities Act and will be governed by the final adjudication of 
such issue.






































                               II - 5


<PAGE>



                              SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that 
it meets all of the requirements for filing on Form S-3 and has duly 
caused this Amendment to the Registration Statement to be signed on its 
behalf by the undersigned, thereunto duly authorized, in the City of 
South San Francisco, State of California, on the     31st of March, 
1995.     


                                     GENENTECH, INC.



                                        By /S/LOUIS J. LAVIGNE, JR.
                                        _____________________
                                        Louis J. Lavigne, Jr.
                                        Senior Vice President and
                                        Chief Financial Officer 







































                                 II - 6

<PAGE>



       Pursuant to the requirements of the Securities Act of 1933, 
this Amendment to the Registration Statement has been signed below by 
the following persons in the capacities indicated, as of     March 31,
1995.    

         Signature                             Title


              *
       --------------------           Chairman of the Board
       Robert A. Swanson                       and Director


              *
       --------------------                       President,
       G. Kirk Raab                         Chief Executive
                                       Officer and Director


       /S/LOUIS J. LAVIGNE, JR.   Senior Vice President and
       -----------------------      Chief Financial Officer
       Louis J. Lavigne, Jr.   (Principal Financial Officer)


              *
       --------------------       Vice President,Controller
       Bradford S. Goodwin    (Principal Accounting Officer)


              *
       --------------------                        Director
       Herbert W. Boyer


              *
       --------------------                        Director
       Jurgen Drews


              *
       --------------------                        Director
       Armin M. Kessler


              *
       --------------------                        Director
       Linda Fayne Levinson


              *
       --------------------                        Director
       J. Richard Munro


              *
       --------------------                        Director
       Donald L. Murfin


                             II-7

<PAGE>



       

              *
       --------------------.                       Director
       John T. Potts, Jr.


              *
       --------------------                        Director
       C. Thomas Smith


              *
       --------------------                        Director
       David S. Tappan





   * By: /S/LOUIS J. LAVIGNE, JR.
         ----------------------------
         Louis J. Lavigne, Jr.
         Attorney-in-Fact





























                                   II - 8
<PAGE>










                                                           Exhibit 23.1


           CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the reference to our firm under the caption "Experts" in 
the Registration Statement (Form S-3 A-3) and related prospectus of 
Genentech, Inc. for the registration of 4,500,000 shares of its 
redeemable common stock and to the incorporation by reference therein of 
our report dated January 17, 1995, with respect to the consolidated 
financial statements of Genentech, Inc. incorporated by reference in its 
Annual Report (Form 10-K) for the year ended December 31, 1994 and the 
related financial statement schedule included therein, filed with the 
Securities and Exchange Commission.



                                                  Ernst & Young LLP



San Jose, California
March 28, 1995




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