GENENTECH INC
SC 13D, 1995-04-21
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                    UNITED STATES
                           SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C.  20549

                                     SCHEDULE 13D
                       Under the Securities Exchange Act of 1934*
                                  (Amendment No. 1)

                                    SCIOS NOVA INC.
- -------------------------------------------------------------------------------
                                   (Name of Issuer)

                                     Common Stock
- -------------------------------------------------------------------------------
                            (Title of Class of Securities)

                                      808905 10 3
- -------------------------------------------------------------------------------

                                     (CUSIP Number)

                                      Richard L. Casey
                            Chairman and Chief Executive Officer
                                       Scios Nova Inc.
                                    2450 Bayshore Parkway
                                   Mountain View, CA  94043
                                     (415)  966-1550
- -------------------------------------------------------------------------------
                    (Name, Address and Telephone Number of Person Authorized
                              to Receive Notices and Communications)

                                        April 10, 1995

- -------------------------------------------------------------------------------
                 (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report 
the acquisition which is the subject of this Schedule 13D, and is filing this 
schedule of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with this statement.  [ ] (A fee 
is not  required only if the reporting person:  (1) has a previous statement on 
file reporting beneficial ownership of more than five percent of the class of 
securities described in Item 1; and (2) has filed no amendment subsequent 
thereto reporting beneficial ownership of less than five percent of such 
class). (See Rule 13d-7.)

Note:  This document is being electronically filed with the Commission, using 
the EDGAR system.  Additionally, one paper copy of the filing will subsequently 
be sent to the Commission.  See Rule 13d-1(a) for other parties to whom copies 
are to be sent.

*The remainder of this cover page should be filled out for an initial filing of 
a reporting person on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which would 
alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be 
deemed to be filed for the purpose of Section 18 of the Securities Exchange Act 
of 1934 (Act) or otherwise subject to the liabilities of that section of the 
Act but shall be subject to all other provisions of the Act (however, see the 
Notes).











CUSIP No. 808905 10 3                                               Page 2 of 8

- -------------------------------------------------------------------------------
      (1)  NAMES OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NOS OF
           ABOVE PERSONS

           GENENTECH, INC.
           94-2347624

- -------------------------------------------------------------------------------
      (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                            (a)  [  ]
                                                            (b)  [  ]
          Not Applicable
- -------------------------------------------------------------------------------
      (3) SEC Use Only
- -------------------------------------------------------------------------------
      (4) Source of Funds     

          WC
- -------------------------------------------------------------------------------
      (5) CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
          ITEMS 2(d) OR 2(e)
                         [  ]

          Not Applicable
- -------------------------------------------------------------------------------
      (6) CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware
- -------------------------------------------------------------------------------
NUMBER OF    (7)  SOLE VOTING POWER 1,705,300 consisting of 100,000 shares of
SHARES BENE-      previously acquired Common Stock and 16,053 shares of
FICIALLY          nonvoting Series A Preferred Stock which are convertible into
OWNED BY          1,605,300 shares of Common Stock.
EACH REPORT- (8)  SHARES VOTING POWER
ING PERSON   (8)  0
WITH         (9)  SOLE DISPOSITIVE POWER 1,705,300 consisting of 100,000 shares
                  of previously acquired Common Stock and 16,053 shares of
                  nonvoting Series A Preferred Stock which are convertible into
                  1,605,300 shares of Common Stock
            (10)  SHARED DISPOSITIVE POWER                                    
                   0
- -------------------------------------------------------------------------------
      (11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   
1,705,300 consisting of 100,000 shares of previously acquired Common Stock and 
16,053 shares of nonvoting Series A Preferred Stock which are convertible into 
1,605,300 shares of Common Stock
- -------------------------------------------------------------------------------
      (12) CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES     [  ]
                 Not Applicable
- -------------------------------------------------------------------------------
      (13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

             4.5% of Common Stock
- -------------------------------------------------------------------------------
      (14) TYPE OF REPORTING PERSON

           CO









CUSIP NO. 808905 10 3                                               Page 3 of 8

ITEM 1:  SECURITY AND ISSUER

1.  Class of Securities:  Common Stock issuable upon conversion of Preferred
                          Stock

2.  Issuer:  Scios Nova Inc. (Scios)

3.  Principal Address:  2450 Bayshore Parkway, Mountain View, CA  94043

ITEM 2:  IDENTITY AND BACKGROUND

      a.     Reporting Person:  Genentech, Inc. (Genentech)

      b.     Place of Organization:  Delaware

      c.     Principal Business:  Pharmaceutical company

      d.     Principal Business Address:  460 Point San Bruno Blvd., 
             South San Francisco, CA 94080

      e.     Principal Office:  As above

      f.     Criminal Convictions:  None

      g.     Civil Adjudication of Violation of Securities Laws:  None

Attached hereto as Exhibit A is a list of Genentech's executive officers and 
directors as required by Instruction C to Schedule 13D.

ITEM 3:  SOURCE AND AMOUNT OF FUNDS

Pursuant to the terms of a Preferred Stock Purchase Agreement between Genentech 
and Scios dated December 30, 1994 (the Purchase Agreement), Genentech purchased 
21,053 shares of the Series A Preferred Stock of Scios (the Convertible 
Preferred Stock) for $950.00 per share of Convertible Preferred Stock.  The 
total purchase price of $20,000,350 for the Convertible Preferred Stock was 
paid from the working capital of Genentech.  Each share of Convertible 
Preferred Stock is convertible into 100 shares of the Common Stock of Scios at 
the option of Genentech and will not have voting rights until converted into 
shares of Scios Common Stock.  Each share of Convertible Preferred Stock also 
will automatically convert into 100 shares of Common Stock of Scios upon 
transfer of ownership to a third party unaffiliated with Genentech.  Under the 
Purchase Agreement, Scios, at the request of Genentech, will file resale 
registration statements covering certain of the shares of Common Stock issuable 
upon conversion of the Convertible Preferred Stock.  

Genentech and Scios entered into a Collaboration Agreement dated as of December 
30, 1994.  Under the terms of the Collaboration Agreement, Genentech and Scios 
will collaborate in the development of Auriculin for Acute Renal Failure (ARF) 
in the United States and Canada.  The two companies will co-promote Auriculin 
for ARF in the United States and Canada, and equally share profits from its 
commercialization.  Scios also granted Genentech exclusive marketing rights to 
all other markets outside the United States and Canada and Scios will receive a 
royalty on sales.







CUSIP NO. 808905 10 3                                               Page 4 of 8

In addition, pursuant to the terms of a Note Agreement between Genentech and 
Scios (the Note Agreement), Genentech has provided $30 million that Scios may 
draw down as a loan at its discretion through December 30, 2002.  The loan is 
repayable, at the option of Scios, in the form of cash or shares of Scios 
Common Stock (at the then prevailing market price) at any time through December 
30, 2002.  The loan is supported by a $30 million irrevocable letter of credit 
issued in favor of Scios.

ITEM 4:  PURPOSE OF TRANSACTION

The purpose of the initial purchase of the shares of Convertible Preferred 
Stock described in Item 3 was investment.  Depending on its evaluation of the 
business of Scios, prospects, financial condition, the market for Scios 
securities, other opportunities available to Genentech, general economic 
conditions, general market conditions, other future developments and the 
contractual restrictions described in Item 6, Genentech may decide to sell some 
or all of its investment in the capital stock of Scios through open market 
sales or in negotiated transactions, to or through one or more broker dealers, 
or in underwritten offerings, block trades, agency placements, brokerage 
transactions or otherwise.  Depending on the same factors, Genentech may in the 
future purchase additional capital stock of Scios or enter into hedging or 
similar transactions as described in Item 6.  Based upon such factors, 
Genentech, however, may reduce its equity ownership in a company with publicly 
traded securities to below five percent.

Based upon the factors described above and pursuant to an effective Form S-3 
Registration Statement, between March 31, 1995 and April 10, 1995 Genentech 
sold an aggregate of 5,000 shares of Convertible Preferred Stock, which were 
automatically converted into 500,000 shares of Scios Common Stock upon transfer 
to an unaffiliated third party, for an aggregate sales price of $3,506,250, 
excluding commissions. Additional detail of these sales is set forth on Exhibit 
B.  The purpose of Genentech in effecting the sales was to decrease its 
aggregate equity interest in Scios.

Except as described in this Item 4, Genentech does not have any plan or 
proposal relating to, or which would result in, any event described in (a) - 
(j) of the instructions to this Item 4.

ITEM 5:  INTEREST IN SECURITIES OF ISSUER
       a.     Beneficial Ownership:     1,705,300 (1)
              Percentage Ownership:          4.5%

(1)     On a Common Stock equivalent basis.  Includes 100,000 shares of Scios 
Common Stock acquired by Genentech on October 2,1992 in exchange for a license 
of technology of Genentech to Scios in connection with the termination of a 
prior collaborative arrangement between the parties.

To the best knowledge of the undersigned, except for Genentech, no shares of 
Common Stock of Scios or equity securities convertible into shares of Common 
Stock of Scios, are owned by any of the parties listed in Item 2 above.

       b.     Sole Voting Power:          1,705,300
              Shared Voting Power:                0
              Sole Dispositive Power:     1,705,300
              Shared Dispositive
              Power:                              0





CUSIP NO. 808905 10 3                                               Page 5 of 8

       c.     Recent Transactions:  As described above in Item 4, between March 
31, 1995 and April 10, 1995 Genentech sold an aggregate of 5,000 shares of 
Convertible Preferred Stock, which were automatically converted into 500,000 
shares of Scios Common Stock upon transfer to an unaffiliated third party, for 
an aggregate sales price of $3,506,250, excluding commissions. Additional 
detail of these sales is set forth on Exhibit B.  Except as described herein, 
Genentech has not made any other purchases or sales of Common Stock of Scios in 
the last sixty days.

       d.     Receipt of dividends, etc.:  Not applicable

       e.     Ownership below 5%:  As of April 10, 1995, Genentech was the 
beneficial owner of less than five percent of Scios Common Stock.


ITEM 6:  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIP WITH RESPECT
         TO SECURITIES OF ISSUER

To the best knowledge of the undersigned, except as described below, there are 
no contracts, arrangements, understandings or relationships (legal or 
otherwise) among the person named in Item 2 and between such persons and any 
person with respect to any securities of Scios, including but not limited to 
transfer or voting of any of the securities, finders fees,  joint ventures, 
loan or option agreements, puts or calls, guarantees of profits, division of 
profits or losses, or the giving or withholding of proxies.

Under the Purchase Agreement, Genentech and Scios have agreed as follows:

     1.     With respect to the shares of Convertible Preferred Stock or shares 
of Common Stock issuable upon conversion thereof (Securities), Genentech will 
not, without the approval of Scios, sell to a single third party investor 
(including its affiliates) greater than:  (i) 500,000 Securities in any 12 
month period prior to December 31, 1996, and (ii) 1,000,000 Securities in any 
twelve month period thereafter, except pursuant to a tender offer approved by 
Scios board of directors.  The foregoing volume limitation is inapplicable to 
sales of Securities to brokers or dealers who agree to abide by such volume 
limitation.  In addition, the volume limitation will terminate upon the 
issuance of any shares of Scios Common Stock pursuant to the Note Agreement 
described in Item 2.

     2.     Genentech will not transfer ownership of any of the Securities to 
an unaffiliated third party without first permitting Scios to purchase such 
Securities at the then market price for such Securities.  If  Scios declines to 
purchase any such Securities, Genentech is no longer obligated to offer those 
Securities to Scios before transferring ownership to an unaffiliated third 
party.  In addition to any other termination provision described in (1) above, 
the obligations of Genentech under (1) and (2) terminate upon the earliest to 
occur of (i) December 30, 2002, (ii) the date on which Genentech and its 
affiliates (i.e., companies controlled by Genentech) no longer own 3% of the 
outstanding voting equity securities of Scios, or (iii) the closing of a merger 
or similar transaction pursuant to which greater than 50% of the voting stock 
of Scios is transferred to a stockholder or group of stockholders, or a sale of 
all or substantially all of the assets of Scios.

     3.     Prior to December 30, 1999, neither Genentech nor any of its 
affiliates (i.e., companies controlled by Genentech) nor any one acting on its 
behalf will acquire any Scios equity securities without the written consent of 
Scios, except pursuant to the Note Agreement described in Item 2.  The 
foregoing obligation terminates earlier upon the receipt of Scios of a firm 
offer from a third party to acquire more than 50% of Scios' voting stock or all 
or substantially all of its assets.


CUSIP NO. 808905 10 3                                               Page 6 of 8

     Subject to the contractual restrictions described above, Genentech may 
from time to time enter into hedging transactions, including short sales and 
buying puts and selling calls, for its own account or with broker-dealers and 
the broker-dealers may engage in short sales of Common Stock of Scios in the 
course of hedging the positions they assume with Genentech.  In connection with 
such transactions, Genentech may also loan or pledge shares of Convertible 
Preferred Stock to a broker-dealer.  As described in Item 2 above, shares of 
Convertible Preferred Stock automatically convert into shares of Common Stock 
upon transfer of ownership to a third party unaffiliated with Genentech.

ITEM 7:  EXHIBITS

None


     After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true, complete and 
correct.


Date: April 20, 1995

GENENTECH, INC.

/S/STEPHEN G. JUELSGAARD
- ------------------------
Stephen G. Juelsgaard
Vice President and 
General Counsel





CUSIP NO. 808905 10 3                                               Page 7 of 8


                                EXHIBIT A


Item 2.

(a)  Name:  Genentech hereby incorporates by this reference from its Form 10-K 
filed with the Securities and Exchange Commission on March 30, 1995 the Section 
in Part I entitled Genentech, Inc., Executive Officers and incorporates by this 
reference from its definitive Proxy Statement filed with the Securities and 
Exchange Commission on March 16, 1995 the Section entitled Proposal
 1 - Election of Directors, Nominees.

(b)  Residence or business address:  The address for each of the officers and 
directors described in Item 2(a) above is:

              c/o  Genentech, Inc.
              460 Point San Bruno Blvd.
              South San Francisco, CA  94080

(c)  Principal Occupation:  Genentech hereby incorporates by this reference 
from its Form 10-K filed with the Securities and Exchange Commission on March 
30, 1995 the Section in Part I entitled Genentech, Inc., Executive Officers and 
incorporates by this reference from its definitive Proxy Statement filed with 
the Securities and Exchange Commission on March 16, 1995 the Section entitled 
Proposal 1 - Election of Directors, Nominees.

(d)  Criminal Proceedings, etc.:  During the last five years, none of the 
individuals described in Item 2(a) above has been convicted in a criminal 
proceeding (excluding traffic violations or similar misdemeanors).

(e)  Civil Proceedings, etc.:  During the last five years, none of the 
individuals described in Item 2(a) above has been a party to a civil proceeding 
of a judicial or administrative body of competent jurisdiction.

(f)  Citizenship:  Each of the individuals described in Item 2(a) above are 
citizens of the United States, except directors Drews and Kessler who are 
citizens of Switzerland.



CUSIP NO. 808905 10 3                                           Page 8 of 8


                                  EXHIBIT B

                      Sales of Scios Nova Inc. Common Stock
          (Transactions effected on NASDAQ Over the Counter Market)
                       (All prices exclude commissions)



           Date                Number of Shares        Price Per Share
                               of Common Stock
- ------------------------------------------------------------------------------
          3/31/95                  50,000                  7.5000
           4/4/95                  50,000                  7.3750
           4/7/95                  50,000                  7.1250
          4/10/95                 350,000                  6.8750





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