GENENTECH INC
SC 13D/A, 1996-02-13
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                 SCHEDULE 13D
                  Under the Securities Exchange Act of 1934*
                              (Amendment No. 14)


                                GENENTECH, INC.

                               (Name of Issuer)

                         CALLABLE PUTABLE COMMON STOCK
                                $.02 PAR VALUE

                        (Title of Class of Securities)

                                   368710307
______________________________________________________________________________
                                (CUSIP Number)

                               Peter R. Douglas
                             Davis Polk & Wardwell
                             450 Lexington Avenue
                              New York, NY  10017
                           Tel. No.:  (212) 450-4000
______________________________________________________________________________
                             (Name, Address and Telephone Number of Person
                                  Authorized
                    to Receive Notices and Communications)

                               February 8, 1996
______________________________________________________________________________
            (Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the following
box [ ].

Check the following box if a fee is being paid with this statement.  [ ] (A
fee is not required only if the reporting person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of less than five percent of such
class).  (See Rule 13d-7.)

Note: This document is being electronically filed with the Commission, using
the EDGAR system.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

*The remainder of this cover page should be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


CUSIP No. 368710307
_________________________________________________________________
      (1)   Names of Reporting Persons S.S. or I.R.S. Identification Nos. of
            Above Persons

            ROCHE HOLDINGS, INC.
            51-0304944
_________________________________________________________________
      (2)   Check the Appropriate Box if a Member of a Group
                                                            (a)   [ ]
                                                            (b)   [ ]
_________________________________________________________________
      (3)   SEC Use Only
_________________________________________________________________
      (4)   Source of Funds         WC
_________________________________________________________________
      (5)   Check if Disclosure of Legal Proceedings is Required Pursuant to
            Items 2(d) or 2(e)
                                          [ ]
_________________________________________________________________
      (6)   Citizenship or Place of Organization

            United States of America
_________________________________________________________________
Number of       (7)  Sole Voting Power                      4,000,000 Shares
Shares Bene-                                    Callable Putable Common Stock
  ficially
  Owned by
Each Report-     (8)  Shared Voting Power                            0 Shares
ing Person
   With          (9)  Sole Dispositive Power                 4,000,000 Shares
                                                Callable Putable Common Stock


                (10)  Shared Dispositive Power                       0 Shares
_________________________________________________________________
      (11)  Aggregate Amount Beneficially Owned by Each Reporting Person

                   4,000,000 Shares of Callable Putable Common Stock
_________________________________________________________________
      (12)  Check if the Aggregate Amount in Row (11) Excludes Certain Shares
                      [ ]

_________________________________________________________________
      (13)  Percent of Class Represented by Amount in Row (11)

            9.49% of Callable Putable Common Stock;
_________________________________________________________________
      (14)  Type of Reporting Person (See Instructions)

                              CO, HC


            The following information amends and supplements the Schedule 13D
dated September 17, 1990, as previously amended (as so amended, the "Schedule
13D").

            Item 1. Security and Issuer.

            This statement relates to the Callable Putable Common Stock, par
value $.02 per share (the "Special Common Stock" and together with the Common
Stock, par value $0.02 per share, the "Common Shares") of Genentech, Inc., a
Delaware corporation (the "Company"). The principal executive offices of the
Company are located at 460 Point San Bruno Boulevard, San Francisco,
California 94080.

            Item 2. Identity and Background.

            This statement is filed by Roche Holdings, Inc., a Delaware
corporation ("Purchaser") and wholly owned subsidiary of Roche Finance Ltd, a
Swiss corporation ("Finance") and wholly owned subsidiary of Roche Holding
Ltd, a Swiss corporation ("Holding").  Dr. h.c. Paul Sacher, an individual and
citizen of Switzerland ("Dr. Sacher") has, pursuant to an agreement, the power
to vote a majority of the voting securities of Holding.  Purchaser, Finance,
Holding and Dr. Sacher are herein referred to collectively as the "Reporting
Persons".

            The address of the principal offices of Purchaser is 15 East North
Street, Dover, Delaware 19901.  The address of the principal offices of
Finance is Grenzacherstrasse 122, Basel, Switzerland.  The address of the
principal offices of Holding is Grenzacherstrasse 124, Basel 4002,
Switzerland.  The business address of Dr. Sacher is Haus auf Burg,
Muensterplatz 4, Basel 4051, Switzerland.

            Item 3. Source and Amount of Consideration

            The aggregate purchase price for the 4,000,000 shares of the
Special Common Stock acquired by Purchaser between October 30, 1995 and
February 8, 1996 as described in Item 4 was $219,992,625, excluding
commissions, and was financed from working capital of the Purchaser.

            Item 4. Purpose of Transaction

            Between October 30, 1995, on which date Amendment 13 to the
Schedule 13D was filed, and February 8, 1996, the Purchaser purchased an
aggregate of 4,000,000 shares of the Special Common Stock for an aggregate
purchase price of $219,992,625, excluding commissions.  Certain information
with respect to purchases of Special Common Stock during the 60 day period
preceding the date of this Amendment is set forth in Schedule D.

            Subject to market conditions and other factors (including limits
imposed by the Amended Governance Agreement between Purchaser and the
Company), the Purchaser expects that it or its affiliates may acquire
additional shares of  Special Common Stock from time to time in the future in
open-market, privately negotiated or other transactions.

            The purpose of the Purchaser, Finance and Holding in effecting the
purchase of Special Common Stock referred to above was to increase their
aggregate equity interest in the Company.

            Item 5.  Interest in the Securities of the Issuer.

            (a)  The Purchaser is the beneficial owner of 76,621,009 shares of
Common Stock (100% of the Common Stock outstanding) and 4,000,000 shares of
the Special Common Stock (approximately 9.49% of the 42,158,137 shares of
Special Common Stock outstanding) as of September 30, 1995 according to the
Company's Form 10-Q for the quarter then ended (the "10-Q") and the Company's
Amendment No. 2 to the Registration Statement on Form S-4 filed with the
Securities and Exchange Commission on September 18, 1995, which together
represent approximately 67.87% of the Common Shares outstanding as of
September 30, 1995.  The Company, in its 10-Q, reported that as of September
30, 1995, 118,779,146 Common Shares were outstanding; the Purchaser, as of
that date, owned 76,621,009 Common Shares.  The remainder of the Common Shares
(42,158,137) were converted on October 25, 1995, as a result of the Merger
described in Amendment 13 to this Schedule 13D, into an equal number of shares
of Special Common Stock.

            Transactions by the Reporting Person in Special Common Stock
within the 60 days preceding the date of this Amendment are described in Item
4 and in Schedule D.

            Except as set forth herein, neither the Reporting Persons nor any
other person controlling the Reporting Persons nor, to the best of their
knowledge, any of the persons named in Schedules A, B and C hereto
beneficially owns any Common Shares, except that Prof. Jurgen Drews owns 200
shares of Special Common Stock and has been granted stock options by the
Company to purchase 15,000 shares of Special Common Stock at $25.50 per share,
all of which are issuable under currently exercisable stock options, 15,000
shares of Special Common Stock at $26.50 per share, all of which are issuable
under currently exercisable stock options, and 15,000 shares of Special Common
Stock at $50.375, none of which are issuable under currently exercisable stock
options or options exercisable within sixty days of February 8, 1996; and Dr.
Franz B. Humer has been granted stock options by the Company to purchase
15,000 shares of Special Common Stock at $48.875, none of which are issuable
under currently exercisable stock options or options exercisable within sixty
days of February 8, 1996.

            (b)  Except as otherwise described herein, none of the Reporting
Persons has any sole or shared power to vote or to direct the vote of any
Common Shares nor sole or shared power to dispose of or direct the disposition
of any Common Shares.

            (c)  No transactions in Common Shares have been effected during
the past 60 days by the Reporting Persons nor any other person controlling the
Reporting Persons nor, to the best of their knowledge, any of the persons
named in Schedules A, B and C hereto.

            Item 6.     Contracts, Arrangements, Understandings or
                        Relationships with Respect to Securities of the Issuer.

            There are no contracts, arrangements, understandings or
relationships among the persons named in Item 2 or between any of such persons
and any other person with respect to any securities of the Company except as
referred to or described herein, in the Schedule 13D and previous amendments
thereto.

            Item 7.  Material Filed as Exhibits.

            NONE


            After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and accurate.

Dated:  February 12, 1996


                                          ROCHE HOLDINGS, INC.


                                          By Henri B. Meier
                                             Name:  Henri B. Meier
                                             Title:   Vice President, Finance,
                                                      Accounting




                                                      SCHEDULE A


                      Executive Officers and Directors(*)
                                      of
                             Roche Holdings, Inc.


            The names of the Directors and the names and titles of the
Executive Officers of Roche Holdings, Inc. and their business addresses and
principal occupations are set forth below.  If no address is given, the
Director's or Executive Officer's business address is that of Roche Holding
Ltd.  Unless otherwise indicated, each occupation set forth opposite an
individual's name refer to Roche Holding Ltd and each individual is a Swiss
citizen, except that Mr. Schiller is a citizen of the United States.


                                          Present Principal
Name, Business Address                     Occupation
- ----------------------                    -----------------

*Mr. Fritz Gerber                         Chairman of the Board,
(President)                               President and
                                          Chief Executive Officer

*Dr. Henri B. Meier                       Chief Financial Officer
(Vice President and
Treasurer)

Peter N. Schiller                         Attorney-at-Law
Hoffstots Lane
Sands Point, New York  11050
(Secretary)

                                                                    SCHEDULE B


                      Executive Officers and Directors(*)
                                      of
                               Roche Finance Ltd


            The names of the Directors and the names and titles of the
Executive Officers of Roche Finance Ltd and their business addresses and
principal occupations are set forth below.  If no address is given, the
Director's or Executive Officer's business address is that of Roche Holding
Ltd.  Unless otherwise indicated, each occupation set forth opposite an
individual's name refers to Roche Holding Ltd and each individual is a Swiss
citizen.

                                                Present Principal
Name, Business Address                           Occupation
- ----------------------                          -----------------

*Mr. Fritz Gerber                               Chairman of the Board,
(President)                                     President and
                                                 Chief Executive Officer

*Dr. Andres F. Leuenberger                      Vice Chairman of the
                                                Board

*Dr. Henri B. Meier                             Chief Financial Officer



                                                                    SCHEDULE C


                      Executive Officers and Directors(*)
                                      of
                               Roche Holding Ltd


            The names of the Directors and the names and titles of the
Executive Officers of Roche Holding Ltd and their business addresses and
principal occupations are set forth below.  If no address is given, the
Director's or Executive Officer's business address is that of Roche Holding
Ltd.  Unless otherwise indicated, each occupation set forth opposite an
individual's name refers to Roche Holding Ltd and each individual is a Swiss
citizen, except that Dr. Drews is a German citizen and Mr. Belingard is a
French citizen.


                                          Present Principal
Name, Business Address                    Occupation
- ----------------------                    -----------------


*Mr. Fritz Gerber                         Chairman of the Board and
                                           Chief Executive Officer

*Dr. Lukas Hoffmann                       Vice Chairman of the Board
Le petit Essert                           Vice Chairman of WWF
1147 Montricher, Switzerland              International
                                           (a nonprofit organization)

*Dr. Andres F. Leuenberger                Vice Chairman and Delegate
                                           of the Board

*Dr. h.c. Paul Sacher                     Conductor and Founder of
Haus auf Burg                             Paul Sacher Foundation
Muensterplatz 4                           (a nonprofit organization)
4051 Basel, Switzerland

*Dr. Franz B. Humer                       Member of the Executive
                                           Committee, Head of
                                           Pharmaceuticals Division

*Dr. Henri B. Meier                       Member of the Executive
                                           Committee, Chief Financial
                                           Officer

*Dr. Jakob Oeri                           Surgeon and retired
St. Alban - Vorstadt 71                   Head Physician,
4052 Basel, Switzerland                    Kantonsspital Basel
                                           (hospital)

*Prof. jur. Kurt Jenny                    Lawyer
Aeschengraben 18
4051 Basel, Switzerland

*Prof. Dr. Werner Stauffacher             Head of Department of
Head of Department                        Research, University of
of Research                               Basel
University of Basel
Hebelstrasse 32
4056 Basel, Switzerland

*Prof. Charles Weissmann                  Professor, University of
Institut fur                              Zurich
Molekularbiologie I
1er Universitaet Zurich
Hoenggerberg
8093 Zurich, Switzerland

Dr. Markus Altwegg                        Member of the Executive
                                           Committee, Head of
                                           Pharma Stammhaus Basel,
                                           Group Informatics

Mr. Jean-Lock Belingard                   Member of the Executive
                                           Committee, Head of
                                           Diagnostics Division

Dr. Roland Bronnimann                     Member of the Executive
                                           Committee, Head of Vitamin
                                           and Fine Chemicals Division

Prof. Jurgen Drews                        Member of the Executive
                                           Committee, Head of
                                           Research and Development




                                                                    SCHEDULE D


                       Purchases of Special Common Stock
                     (all transactions effected on NYSE,
                               except as noted)
                       (all prices exclude commissions)


             Date      Number of Shares      Price Per Share
- -----------------    ------------------    -----------------
           2-8-96                12,000                   55
                                 53,000               54.875
                                  3,000                54.75
                              3,932,000                  55*
                     ------------------
                              4,000,000

__________________________

  * Executed in the third market.


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