GENENTECH INC
10-Q, 1996-05-15
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                        SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC  20549

                                    FORM 10-Q

                                    (Mark One)

X      Quarterly report pursuant to Section 13 or 15(d) of the Securities
       Exchange Act of 1934. For the quarterly period ended March 31, 1996.

       Transition report pursuant to Section 13 or 15(d) of the Securities
       Exchange Act of 1934. For the transition period from   to   .


                               Commission File Number
                                       1-9813

                                   GENENTECH, INC.
               (Exact name of registrant as specified in its charter)

           Delaware                                         94-2347624
(State or other jurisdiction of                          (I.R.S. employer
incorporation or organization)                        identification number)

        460 Point San Bruno Boulevard, South San Francisco, California  94080
                (Address of principal executive offices and zip code)

                                    (415) 225-1000
                 (Registrant's telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports 
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period that the 
registrant was required to file such reports), and (2) has been subject to 
such filing requirements for the past 90 days.  Yes  X     No

Indicate the number of shares outstanding of each of the issuer's classes of 
common stock, as of the latest practicable date.

Common Stock $.02 par value                    76,621,009
Class                                          Outstanding at March 31, 1996

Special Common Stock $.02 par value            43,536,205
Class                                          Outstanding at March 31, 1996







                                   GENENTECH, INC.
                                        INDEX


PART I.     FINANCIAL INFORMATION                                    PAGE NO.

Condensed Consolidated Statements of Income -
for the three months ended March 31, 1996 and 1995                        3

Condensed Consolidated Statements of Cash Flows -
for the three months ended March 31, 1996 and 1995                        4

Condensed Consolidated Balance Sheets -
March 31, 1996 and December 31, 1995                                      5

Notes to Condensed Consolidated Financial Statements                    6-9

Financial Review                                                      10-16

Independent Accountants' Review Report                                   17

PART II.     OTHER INFORMATION                                           18

SIGNATURES                                                               19


































                                      Page 2



                          PART I.  FINANCIAL INFORMATION
<TABLE>
                                  GENENTECH, INC.
                    CONDENSED CONSOLIDATED STATEMENTS OF INCOME
                       (thousands, except per share amounts)
                                    (unaudited)
<CAPTION>

                                                                   Three Months
                                                                  Ended March 31
                                                              ----------------------
                                                                 1996        1995
                                                              ----------  ----------
<S>                                                           <C>          <C>
Revenues:
  Product sales (including amounts from related parties:
    1996-$3,955; 1995-$0)                                      $152,337     $162,067
  Royalties (including amounts from related parties:
    1996-$6,627; 1995-$2,396)                                    52,893       47,149
  Contract and other (including amounts from 
    related parties: 1996-$18,757; 1995-$5,184)                  22,100       16,222
  Interest                                                       15,554       13,529
                                                              ----------  ----------
     Total revenues                                             242,884      238,967

Costs and expenses:
  Cost of sales (including amounts from related parties:
    1996-$3,463; 1995-$0)                                        25,879       26,750
  Research and development                                      115,633       94,959
  Marketing, general and administrative                          52,042       64,323
  Interest                                                        1,559        1,871
                                                              ----------  ----------
    Total costs and expenses                                    195,113      187,903

Income before taxes                                              47,771       51,064

Income tax provision                                              9,554        7,660
                                                              ----------  ----------
Net income                                                    $  38,217   $   43,404
                                                              ==========  ==========
Net income per share                                          $     .31   $      .36
                                                              ==========  ==========
Weighted average number of shares used
  in computing per share amounts                                123,360      120,493
                                                              ==========  ==========

<FN>
              See notes to condensed consolidated financial statements.
</TABLE>













                                      Page 3



<TABLE>
                                   GENENTECH, INC.
                   CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                     (thousands)
                                     (unaudited)
<CAPTION>
                                                                  Three Months
                                                                 Ended March 31
                                                              ----------------------
                                                                 1996        1995
                                                              ----------  ----------
<S>                                                          <C>         <C>
Cash flows from operating activities:
  Net income                                                  $  38,217   $  43,404
  Adjustments to reconcile net income to net cash provided
   by operating activities:
   Depreciation and amortization                                 15,403      14,345
   Deferred income taxes                                         (2,400)          -
   Gain on sales of securities available-for-sale                   (84)     (4,034)
   Writedown of a security available-for-sale                         -         427
   Loss on fixed asset dispositions                                  95           2
  Changes in assets and liabilities:
     Receivables and other current assets                        (3,559)    (27,272)
     Inventories                                                  4,795       8,900
     Accounts payable, other current liabilities
       and other long-term liabilities                           (7,212)    (16,754)
                                                              ----------  ----------
  Net cash provided by operating activities                      45,255      19,018

Cash flows from investing activities:
  Purchases of securities held-to-maturity                     (136,420)   (154,860)
  Proceeds from maturities of securities held-to-maturity       147,237     316,319
  Purchases of securities available-for-sale                    (62,595)   (139,276)
  Proceeds from sales of securities available-for-sale            1,424       5,053
  Capital expenditures                                          (24,252)     (9,558)
  Change in other assets                                          4,303     (27,771)
                                                              ----------  ----------
  Net cash used in investing activities                         (70,303)    (10,093)

Cash flows from financing activities:
  Stock issuances                                                27,115       9,062
  Additions to long-term debt and
   short-term borrowings                                              -      25,624
  Repayment of long-term debt, including
   current portion                                                 (230)       (211)
                                                              ----------  ----------
  Net cash provided by financing activities                      26,885      34,475
                                                              ----------  ----------
Net increase in cash and cash equivalents                         1,837      43,400
  Cash and cash equivalents at beginning of period              137,043      66,713
                                                              ----------  ----------
  Cash and cash equivalents at end of period                  $ 138,880   $ 110,113
                                                              ==========  ==========




<FN>
              See notes to condensed consolidated financial statements.
</TABLE>


                                     Page 4




<TABLE>
                                   GENENTECH, INC.
                        CONDENSED CONSOLIDATED BALANCE SHEETS
                                     (thousands)
<CAPTION>
                                                       March 31,        December 31,
                                                         1996               1995
                                                      ------------      ------------
ASSETS                                                (unaudited)
<S>                                                  <C>               <C>
Current assets:
  Cash and cash equivalents                           $    138,880      $    137,043
  Short-term investments                                   622,269           603,296
  Accounts receivable, net (including amounts 
    from related parties: 1996-$38,290;
    1995-$19,281)                                          174,865           172,160
  Inventories                                               88,853            93,648
  Prepaid expenses and other current assets                 39,530            39,267
                                                      ------------      ------------
     Total current assets                                1,064,397         1,045,414

Long-term marketable securities                            386,664           356,475
Property, plant and equipment, less
  accumulated depreciation
 (1996-$281,554; 1995-$268,751)                            514,461           503,654
Other assets                                               100,146           105,452
                                                      ------------      ------------
Total assets                                          $  2,065,668      $  2,010,995
                                                      ============      ============
LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts and notes payable                          $     33,336      $     37,459
  Other current liabilities (including 
    amounts due to related parties:
    1996-$9,872; 1995-$8,475)                              191,041           195,985
                                                      ------------      ------------
     Total current liabilities                             224,377           233,444

Long-term debt                                             150,000           150,000
Other long-term liabilities                                 25,979            25,504
                                                      ------------      ------------
     Total liabilities                                     400,356           408,948

Stockholders' equity:
  Preferred stock                                                -                 -
  Special common stock                                         871               853
  Common stock                                               1,532             1,532
  Other stockholders' equity                             1,662,909         1,599,662
                                                      ------------      ------------
Total stockholders' equity                               1,665,312         1,602,047
                                                      ------------      ------------
Total liabilities and stockholders' equity            $  2,065,668      $  2,010,995
                                                      ============      ============


<FN>
            See notes to condensed consolidated financial statements.
</TABLE>



                                     Page 5


                                GENENTECH, INC.
             NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                  (unaudited)

Note 1.     Statement of Accounting Presentation

In the opinion of Genentech, Inc. (the Company), the accompanying unaudited 
condensed consolidated financial statements have been prepared in 
accordance with generally accepted accounting principles for interim 
financial information and with the instructions to Form 10-Q and Article 10 
of Regulation S-X.  Accordingly, they do not include all of the information 
and footnotes required by generally accepted accounting principles for 
complete financial statements.  In the opinion of management, all 
adjustments (consisting only of adjustments of a normal recurring nature) 
considered necessary for a fair presentation have been included.  Operating 
results for the three-month periods ended March 31, 1996 and 1995 are not 
necessarily indicative of the results that may be expected for the year 
ending December 31, 1996.  The condensed consolidated balance sheet as of 
December 31, 1995 has been derived from the audited financial statements as 
of that date.  For further information, refer to the consolidated financial 
statements and footnotes thereto included in the Company's Annual Report to 
Stockholders for the year ended December 31, 1995.

The preparation of financial statements in conformity with generally accepted 
accounting principles requires management to make estimates and assumptions 
that affect the amounts reported in the financial statements and accompanying 
notes. Actual results could differ from those estimates.

Note 2.     New Accounting Standards

In March 1995, the Financial Accounting Standards Board (FASB) issued 
Statement of Financial Accounting Standards (FAS) 121, "Accounting for the 
Impairment of Long-Lived Assets and for Long-Lived Assets to Be Disposed Of," 
which requires the Company to review for impairment long-lived assets, certain 
identifiable intangibles, and goodwill related to those assets whenever events 
or changes in circumstances indicate that the carrying amount of an asset may 
not be recoverable.  In certain situations, an impairment loss would be 
recognized. The Company adopted FAS 121 in the quarter ended March 31, 1996.  
The adoption did not have a material impact on the financial position, results 
of operations or cash flows of the Company.

In October 1995, the FASB issued FAS 123 "Accounting for Stock-Based 
Compensation" which also is effective for the Company's 1996 fiscal year.  FAS 
123 allows companies which have stock-based compensation arrangements with 
employees to adopt a new fair-value basis of accounting for stock options and 
other equity instruments, or to continue to apply the existing accounting 
rules under APB Opinion 25 "Accounting for Stock Issued to Employees" but with 
additional financial statement disclosure. The Company will continue to 
account for stock-based compensation arrangements under APB Opinion 25, 
therefore the adoption of FAS 123 did not have a material impact on its 
financial position, results of operations, or cash flows.

Note 3.     Agreement with Roche Holdings, Inc.

On October 25, 1995, a new agreement (the Agreement) with Roche Holdings, Inc. 
(Roche) was approved by Genentech's non-Roche stockholders to extend for four 
years Roche's option to cause Genentech to redeem the outstanding callable 
putable common stock (special common stock) of the Company at predetermined 
prices. In conjunction with the Agreement, F. Hoffmann-La Roche Ltd. (HLR)


                                   Page 6


                               GENENTECH, INC.
             NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                  (unaudited)

was granted an option at terms discussed below for ten years for licenses to 
use and sell certain of Genentech's products in non-U.S. markets.  As a 
general matter, such option for a Genentech product must be exercised at, or 
prior to if Genentech mutually agrees, the conclusion of phase II clinical 
trials for each product.  In general, for each product for which HLR exercises 
its option (option product), the Company and HLR will share equally all 
development expenses, including preclinical, clinical, process development and 
related expenses, incurred by the Company through that date and prospectively, 
with respect to the development of the option product in the United States.  
HLR will pay all non-U.S. development expenses. At the Company's election, and 
with HLR's consent, HLR may reimburse Genentech for HLR's share of development 
costs incurred prior to HLR's option exercise date, by payment of such costs 
at the time of the option exercise, or by making payments prospectively until 
HLR's share has been fully reimbursed to Genentech. In general, Genentech will 
supply HLR's clinical requirements of option products at cost and its 
commercial requirements at cost plus 20%.  In general, HLR will pay a royalty 
of 12.5% until an option product reaches $100 million in aggregate sales 
outside of the United States, at which time the royalty rate increases to 15%. 
In addition, HLR has exclusive rights to, and pays the Company 20% royalties 
on, Canadian sales of the Company's existing approved products in Canada, and 
European sales of Pulmozyme, registered trademark.  Consequently, in the 
fourth quarter of 1995, the Company transferred to HLR the rights to its 
Canadian product sales, and its European sales of Pulmozyme, and commenced 
recording royalty revenue from HLR on such sales.

In the first quarter of 1996, HLR exercised its option with respect to the 
development of IDEC-C2B8.  Accordingly, contract revenue recorded in the 
quarter includes $17.1 million for HLR's exercise, representing a one time 
option fee of $13.1 million, which includes reimbursement for development 
costs incurred by Genentech prior to HLR's exercise date and for certain Asian 
marketing rights, and $4.0 million for reimbursement of development costs 
incurred by Genentech after the exercise date but before March 31, 1996. HLR 
also advised Genentech that it would not exercise its option with respect to 
the development of Genentech's anti-HER2 antibody.

Note 4.     Legal Proceedings

The Company is a party to various legal proceedings including patent 
infringement cases involving human growth hormone products and Activase, 
registered trademark; a patent infringement and trade secret misappropriation 
case involving antibodies to IgE; product liability cases involving Activase 
and Protropin, registered trademark; class action lawsuits regarding 
Protropin; and employment related cases. In addition, the Company has received 
and responded to grand jury document subpoenas from the United States District 
Court for the Northern District of California for documents relating to 
Genentech's clinical, sales, and marketing activities associated with human 
growth hormone. 

The Company, its directors, two former directors and Roche are defendants in a 
number of suits filed in Delaware, which have been consolidated in a single 
action, by certain individual stockholders purporting to represent 
stockholders as a class alleging, in general, breach of the defendants' 
fiduciary duties to the Company in connection with the then proposed extension 
of Roche's option to cause the Company to redeem the outstanding non-Roche 
owned redeemable common stock and transactions related thereto.  The Company, 
Roche and the attorneys representing the plaintiff stockholders have entered 
into a memorandum of understanding settling all claims against the defendants 


                                   Page 7

                                GENENTECH, INC.
             NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                  (unaudited)

in these actions.  In connection with the settlement, if approved by the 
court, Roche would increase the prices at which it could cause Genentech to 
redeem the non-Roche owned special common stock by $0.50 per share per 
quarter, to a final price of $82.50 in the quarter ending June 30, 1999, and 
Genentech would pay the plaintiffs' attorneys up to $3.5 million in attorneys 
fees, and in connection with the then proposed merger, Genentech would absorb 
the termination costs of up to six Europe-based Genentech employees.

On June 28, 1995 and August 10, 1995, the U.S. District Court for the Southern 
District of New York issued preliminary injunctions against Novo Nordisk A/S 
and certain of its affiliates (Novo) and Biotechnology General Corporation and 
its affiliate (BTG), respectively, which prohibited each of them, pending the 
Court's final determination of the action, from importing, making, using and 
selling their human growth hormone products in the United States. Each of Novo 
and BTG appealed the Court's decision. On February 26, 1996, the U.S. Court of
Appeals for the Federal Circuit overruled the preliminary injunction against 
Novo. On April 8, 1996, the same court upheld the preliminary injunction 
against BTG. Future court decisions will determine whether Novo's and BTG's 
products will be preliminarily or permanently enjoined from the U.S. market.

Based upon the nature of the claims made and the investigations completed to 
date by the Company and its counsel, the Company believes the outcome of the 
above actions will not have a material adverse effect on the financial 
position, results of operations or cash flows of the Company. However, were an 
unfavorable ruling to occur in any quarterly period, there exists the 
possibility of a material impact on the net income of that period.


Note 5.     Inventories

Inventories at March 31, 1996 and December 31, 1995 are summarized below:


                                           1996            1995
                                        ----------      ----------
                                                (thousands)

            Raw materials               $  14,574       $  12,808
            Work in process                64,428          67,239
            Finished goods                  9,851          13,601
                                        ----------      ----------
                Total                   $  88,853       $  93,648
                                        ==========      ==========




Note 6.     Quasi-Reorganization

On February 18, 1988, the Company's Board of Directors approved the 
elimination of the Company's accumulated deficit through an accounting 
reorganization of its stockholders' equity accounts (a quasi-reorganization) 
effective October 1, 1987, that did not involve any revaluation of assets or 
liabilities. The Company eliminated the accumulated deficit of $329.5 million 
by a transfer from additional paid-in capital in an amount equal to the 
accumulated deficit.


                                   Page 8


The Company has been reporting in income the recognition of operating loss and 
tax credit carryforward items arising prior to the quasi-reorganization due to 
the Company's adoption of its quasi-reorganization in the context of the 
accounting and quasi-reorganization literature existing at the date the quasi-
reorganization was effected. If the provisions of the subsequently issued 
Staff Accounting Bulletin 86 (SAB 86) had been applied, net income for the 
quarter ended March 31, 1995, would have been reduced by $10.0 million or $.08 
per share, because SAB 86 would require that the tax benefits of prior 
operating loss and tax credit carryforwards be reported as a direct addition 
to additional paid-in capital rather than being recorded in the income 
statement. The Securties and Exchange Commission staff has indicated that it 
would not object to the Company's accounting for such tax benefit. As of June 
30, 1995, the operating loss and tax credit carryforwards arising prior the 
quasi-reorganization had been fully utilized; thus there was no impact for the 
quarter ended March 31, 1996.

Note 7.     Subsequent Event - Research and Development Collaboration

In April 1996, the Company entered into a collaboration with Xoma Corporation 
(Xoma) for the development of Genentech's anti-CD11a monoclonal antibody for 
the treatment of psoriasis and organ transplant rejection.  In connection with 
the collaboration, Genentech purchased 1.5 million shares of Xoma common stock 
for $8.8 million.  In addition, Genentech loaned Xoma $5.0 million pursuant to 
a convertible note. Under the terms of the collaboration, Genentech expects to 
make additional loans to Xoma to be used for the product's development.  Xoma 
is responsible for the development of anti-CD11a through Phase II trials.  
After completion of Phase II trials, Genentech will determine the product's 
future development strategy.  Upon meeting certain milestones, Xoma will have 
an option to participate in development through U.S. approval, after which it 
will have the right to copromote and share in the profits of the product in 
the United States, and to receive royalties from its sales elsewhere. 






























                                       Page 9


                               GENENTECH, INC.
                              FINANCIAL REVIEW


AGREEMENT WITH ROCHE HOLDINGS, INC.

On October 25, 1995, a new agreement (the Agreement) with Roche Holdings, Inc. 
(Roche) was approved by Genentech's non-Roche stockholders to extend for four 
years Roche's option to cause Genentech (the Company) to redeem the 
outstanding callable putable common stock (special common stock) of the 
Company at predetermined prices. In conjunction with the Agreement, F. 
Hoffman-La Roche Ltd. (HLR) was granted an option at terms discussed below for 
ten years for licenses to use and sell certain of Genentech's products in non-
U.S. markets.  As a general matter, such option for a Genentech product must 
be exercised at, or prior to if Genentech mutually agrees, the conclusion of 
phase II clinical trials for each product.  In general, for each product for 
which HLR exercises its option (option product), the Company and HLR will 
share equally all development expenses, including preclinical, clinical, 
process development and related expenses, incurred by the Company through that 
date and prospectively, with respect to the development of the option product 
in the United States.  HLR will pay all non-U.S. development expenses. At the 
Company's election, and with HLR's consent, HLR may reimburse Genentech for 
HLR's share of development costs incurred prior to HLR's option exercise date, 
by payment of such costs at the time of the option exercise, or by making 
payments prospectively until HLR's share has been fully reimbursed to 
Genentech.  In general, Genentech will supply HLR's clinical requirements of 
option products at cost and its commercial requirements at cost plus 20%.  In 
general, HLR will pay a royalty of 12.5% until an option product reaches $100 
million in aggregate sales outside of the United States, at which time the 
royalty rate increases to 15%.  In addition, HLR has exclusive rights to, and 
pays the Company 20% royalties on, Canadian sales of the Company's existing 
approved products in Canada, and European sales of Pulmozyme, registered 
trademark.  Consequently, in the fourth quarter of 1995, the Company 
transferred to HLR the rights to its Canadian product sales, and its European 
sales of Pulmozyme, and commenced recording royalty revenue from HLR on such 
sales.

In the first quarter of 1996, HLR exercised its option with respect to the 
development of IDEC-C2B8.  Accordingly, contract revenue recorded in the 
quarter includes $17.1 million for HLR's exercise, representing a one time 
option fee of $13.1 million, which includes reimbursement for development 
costs incurred by Genentech prior to HLR's exercise date and for certain Asian 
marketing rights, and $4.0 million for reimbursement of development costs 
incurred by Genentech after the exercise date but before March 31, 1996. HLR 
also advised Genentech that it would not exercise its option with respect to 
the development of Genentech's anti-HER2 antibody.
















                                  Page 10


RESULTS OF OPERATIONS
(dollars in millions, except per share amounts)


                                     Three Months Ended March 31
                                   -------------------------------
REVENUES                             1996       1995     % Change
- ---------                          --------   --------   ---------

Revenues                            $242.9     $239.0        2%
                                   ========   ========   ========= 

PRODUCT SALES
- ----------------------
Activase                            $ 76.6     $ 78.2       (2)%
Protropin and Nutropin                56.0       54.4        3
Pulmozyme                             18.9       28.5      (34)
Actimmune                              0.8        1.0      (20)
                                   --------   --------   ---------
Total product sales                 $152.3     $162.1       (6)%
                                   ========   ========   =========

Overall product sales in the first quarter of 1996 decreased 6% from the 
comparable period in 1995 primarily due to the Agreement with Roche.  Pursuant 
to the Agreement, in the fourth quarter of 1995 Genentech stopped recording 
customer sales of Pulmozyme in Europe and customer sales of each of its 
products in Canada.  The Company instead began to provide its products to HLR 
at cost plus 20% for HLR's sales to customers in these territories, and began 
to receive royalties from HLR on such sales.  In the first quarter of 1996, 
Genentech's product sales to HLR for Canadian and European sales were $4.0 
million; in the comparable period of 1995 Genentech's sales to customers in 
these regions were $13.8 million. On a pro forma basis, including sales to HLR 
in 1996 and excluding Canadian and European customer sales in 1995, total 
product sales in 1996 were $152.3 million, compared to $148.3 million in 1995. 
The Agreement also resulted in higher royalties in 1996 and had a slight 
impact on cost of sales as a percent of sales; see comments below regarding 
these items.

Net sales of Activase, registered trademark, (Alteplase, recombinant) 
recombinant tissue plasminogen activator, decreased 2% in the first quarter of 
1996 compared to the first quarter of 1995, primarily due to the sale in 1995 
of $3.8 million of bulk product to Japanese licensees. $1.0 million of the 
decrease is attributable to the Agreement with Roche. On a pro forma basis as 
described above, 1996 first quarter sales of Activase were $76.6 million, 
compared to $75.9 million in the first quarter of 1995. In March 1996, 
Genentech submitted a supplemental Product License Application to the Food and 
Drug Administration (FDA) for the use of Activase to treat acute ischemic 
stroke.

Net sales of the Company's two growth hormone products - Protropin, registered 
trademark, (somatrem for injection) and Nutropin, registered trademark, 
(somatropin [rDNA origin] for injection) - increased 3% in first quarter of 
1996 over the comparable period in 1995, with an increase in U.S. sales more 
than offsetting the decrease resulting from the transfer of Canadian sales of 
growth hormone to HLR in late 1995. On a pro forma basis, growth hormone sales 
were $56.0 million in 1996 compared to $53.7 million in 1995. In April 1996, 
an appeals court upheld the preliminary injunction against one of the 
Company's possible competitors, prohibiting the sale of that company's growth 
hormone product pending final determination of the action.  Also in April, 
another company received FDA approval to sell its human growth hormone product 
to treat growth inadequacy in children.

                                 Page 11
Net sales of Pulmozyme decreased 34% in the quarter ended March 31, 1996 
compared to the first quarter of 1995, primarily due to the Agreement with 
Roche.  1995 Pulmozyme sales included $10.7 million of sales to European and 
Canadian customers.  In 1996, sales in these territories are made by HLR. On a 
pro forma basis, Pulmozyme sales were $18.9 million in the first quarter of 
1996, compared to $17.8 million in the first quarter of 1995.


                                     Three Months Ended March 31
ROYALTIES, CONTRACT AND             ------------------------------
  OTHER, AND INTEREST INCOME          1996       1995     % Change
- -----------------------------       --------   --------   --------
Royalties                           $ 52.9      $47.1        12%
Contract and other                    22.1       16.2        36
Interest income                       15.6       13.6        15

Royalty income increased 12% in 1996 primarily due to new royalties from HLR 
pursuant to the Agreement.  Under the Agreement, effective in the fourth 
quarter of 1995, Genentech receives royalties from HLR on their sales of 
Genentech products in Europe and Canada.  The first quarter of 1995 did not 
include such royalties because at that time Genentech recorded sales to 
customers in those territories. Royalties in 1996 also included income from 
other new royalty arrangements and higher royalties from existing licensees 
due to increased licensee sales.

Contract and other income increased in the first quarter of 1996 over the 
first quarter of 1995 due to $17.1 million of contract revenue from HLR for 
HLR's exercise of its option regarding IDEC-C2B8, as discussed previously.  
This increase was partially offset by two factors - the inclusion in other 
income in 1995 of $4.0 million of gains on sales on biotechnology equity 
securities; and a decrease in other contract revenue in 1996 resulting from 
normal quarterly variations in the timing of contract benchmark achievements 
and payments.

Interest income increased in 1996 compared to 1995 due to a larger investment 
portfolio and a higher average portfolio yield.  The total investment 
portfolio, consisting of cash and cash equivalents, and short- and long-term 
marketable securities, increased to $1,147.8 million as of March 31, 1996 from 
$942.3 million as of March 31, 1995, and from $1,096.8 million as of December 
31, 1995.

                                     Three Months Ended March 31   
                                    ------------------------------
COSTS AND EXPENSES                    1996       1995     % Change
- --------------------------          --------   --------   --------

Cost of sales                        $ 25.9     $ 26.8       (3)%
Research and development              115.6       94.9       22
Marketing, general and 
  administrative                       52.0       64.3      (19)
Interest expense                        1.6        1.9      (16)
                                    --------   --------   --------
  Total costs and expenses           $195.1     $187.9        4%
                                    ========   ========   ========

Cost of sales as a percent of product sales increased slightly in the first 
quarter of 1996 over the first quarter of 1995 primarily due to the impact of 
lower margin sales to HLR in 1996, pursuant to the Agreement as discussed 
above, partially offset by lower inventory reserves provided ($0.6 million in 
1996 versus $1.7 million in 1995). The 1996 reserve of $0.6 million was


                                 Page 12 


provided for expected obsolescence of certain Activase inventories in 
connection with the discontinuance of the 20 milligram vial configuration of 
the product.  In 1995, a reserve of $1.7 million was provided for expected 
product expiration of certain Activase inventories.

R&D expenses increased 22% in the first quarter of 1996 over the comparable 
period in 1995 due to increased expenditures for scale-up, other process 
improvements and clinical material production for products in Phase II and III 
clinical trials, and other expenses related to Phase III clinical trials, 
primarily for the anti-HER2 antibody for breast cancer.  There was also an 
increased number of projects in early stage development in 1996.  Included in 
R&D expense in 1996 is a $5.0 million payment to Washington University for a 
license for worldwide rights to human neurturin, a neurotrophic factor that 
promotes nerve cell growth and may be useful for the treatment of 
neurodegenerative disorders.  R&D as a percent of revenue was approximately 
48% in the first quarter of 1996.

Marketing, general and administrative expenses decreased in the quarter ended 
March 31, 1996 versus the comparable period in 1995 primarily due to the 
closure of the Company's European and Canadian offices pursuant to the  
Agreement with Roche, and, to a lesser extent, due to lower U.S. sales and 
marketing expenses stemming from the timing of various promotional activities.

Interest expense primarily relates to the Company's 5% convertible 
subordinated debentures.

                                      Three Months Ended March 31
                                    ------------------------------   
INCOME TAXES                          1996       1995    % Change
- -------------                       --------   --------  ---------

Income taxes                         $ 9.6      $ 7.7        25%

The increase in income tax expense was attributable to an increase in the 
estimated effective income tax rate, from 15% in 1995 to 20% in 1996.  The 
rate increased due to the recognition of a greater amount of tax credit 
carryforwards in 1995 than in 1996.

                                     Three Months Ended March 31
                                    ------------------------------   
NET INCOME                            1996       1995     % Change
- -------------------                 --------   --------   --------

Net income                           $38.2      $43.4       (12)%   
Earnings per share                   $ .31      $ .36

Net income decreased in 1996 due to an increase in research and development 
expenses and a higher effective tax rate, which more than offset higher 
revenues from royalties and contract income.


LIQUIDITY AND CAPITAL
  RESOURCES                        March 31, 1996       December 31, 1995
- --------------------------        ----------------     -------------------

Cash, cash equivalents,
 short-term investments
 and long-term marketable
 securities                          $1,147.8              $1,096.8
 
Working capital                         840.0                 812.0


                                     Page 13
Cash generated from operations, maturities of investments and stock issuances 
was used to make investments in marketable securities and capital additions.  
Cash and cash equivalents at March 31, 1996 remained essentially flat compared 
to December 31, 1995.  Working capital increased $28.0 million.

Capital expenditures totaled $24.3 million in the first three months of 1996 
compared to $9.6 million in the same period in 1995.  The increase was 
primarily due to improvements to existing manufacturing and administrative 
facilities in 1996.

FORWARD-LOOKING STATEMENTS

The following statements are forward-looking and are based on the Company's 
current expectations.  The Company's actual results could differ materially 
from these forward-looking statements.

Total Product Sales - The Company anticipates that a year over year decrease 
in total reported quarterly product sales may continue throughout 1996.  
Factors affecting the Company's total product sales include, but are not 
limited to, the amount and timing of Genentech's sales to HLR, the amount of 
sales to customers in the United States and the timing and amount of bulk 
shipments to Japanese licensees.

Activase Sales - The Company faces the possibility of potential new 
competition in the thrombolytic market. Genentech is aware that one company is 
seeking FDA approval to market its product for the treatment of acute 
myocardial infarction (AMI) in the United States, and recently an advisory 
committee of the FDA recommended that the product be approved for such 
treatment. Depending on the extent and type of new competition, the Company's 
total Activase sales could be materially affected.  Other factors affecting 
the Company's Activase sales include, but are not limited to, the timing of 
FDA approval, if any, of new competitive products, pricing decisions made by 
the Company, and the outcome of any patent disputes which may arise in 
connection with the Company's patents for Activase and related processes.

Growth Hormone Sales - The Company continues to face the possibility of new 
competition in the growth hormone market.  Three companies received FDA 
approval in 1995 to market their growth hormone products for treatment of 
growth hormone inadequacy in children.  A fourth company received notice from 
the FDA in April 1996 that such approval is imminent, and additionally is 
seeking approval to sell its human growth hormone to treat AIDS wasting. 
Genentech expects such competition to have an adverse effect on its sales of 
Protropin and Nutropin which, depending on the extent and type of the 
competition, could be material.  Other factors affecting the Company's growth 
hormone sales include, but are not limited to, the timing of FDA approval, if 
any, of new competitive products, the outcome of litigation involving the 
Company's patents for growth hormone and related processes, pricing decisions 
made by the Company, and the availability of third party reimbursement for the 
cost of growth hormone therapy.

Royalty and Contract Revenues - The Company's 1996 royalty and contract 
revenues could continue to vary significantly from the prior year, both on a 
quarterly and annual basis, and future royalties and contract revenues could 
vary significantly from 1996 levels.  Major factors affecting these items 
include, but are not limited to, HLR's decisions to exercise or not exercise 
its options to develop and sell the Company's future products, and variations 
in HLR's sales of Genentech products.

R&D Expenses - The Company intends to continue its commitment to aggressive 
investment in R&D. The Company has announced its intention for R&D spending to 
remain at approximately half of total revenues for the short-term.  Over the 
long-term, however, R&D as a percent of revenues should decrease, although in

                                   Page 14
dollar terms R&D spending is expected to rise as revenues rise. Factors 
affecting the Company's R&D expenses include, but are not limited to, the 
outcome of clinical trials currently being conducted; the number of products
entering into development from preclinical research; future levels of the 
Company's product sales, royalty revenues and contract revenues; the 
possibility of competition with respect to products or technologies under 
development; and decisions by HLR to exercise or not exercise its options to 
develop and sell potential products of the Company in non-U.S. markets and the 
timing of such decisions.

Liquidity - The Company believes that its cash, cash equivalents, and short-
term and long-term investments, together with funds provided by operations and 
leasing arrangements, will be sufficient to meet its foreseeable cash 
requirements. Factors affecting the Company's cash position include, but are 
not limited to, future levels of the Company's product sales, royalty revenues 
and contract revenues.

The above statements are forward-looking and involve a number of risks and 
uncertainties. Among other factors that could cause the Company's actual 
results, including its product sales, royalties, expenses and net income, to 
differ materially from these statements or any other forward-looking 
statements made by, or on behalf of the Company, are the following:

Acceptance of Pulmozyme as a treatment for cystic fibrosis  -  Factors that 
may influence the future sales of Pulmozyme include physician perception of 
the number and kinds of patients who will benefit from such therapy, the 
availability of third party reimbursement for the costs of therapy, the timing 
of the development of alternative therapies for the treatment and care of 
cystic fibrosis, whether and when additional indications are approved for 
Pulmozyme, and the cost of Pulmozyme therapy.

Variation of royalty, contract and other revenues  -  These revenues will 
continue to fluctuate due to the timing of non-U.S. approvals, if any, for 
products licensed to HLR; whether and when contract benchmarks are achieved; 
the initiation of new contractual arrangements, including the exercise of 
product options by HLR, and the timing and amount of related development cost 
reimbursement, if any; and the conclusion of existing arrangements with other 
companies and HLR.

Successful development of products  -  The Company intends to continue to 
develop new products. Successful pharmaceutical product development is highly 
uncertain and is dependent on numerous factors, many of which are beyond the 
Company's control. Products that appear promising in the early phases of 
development may fail to reach the market for numerous reasons. They may be 
found to be ineffective or to have harmful side effects in preclinical or 
clinical testing, may fail to receive necessary regulatory approvals, may turn 
out to be uneconomical because of manufacturing costs or other factors, or 
they may be precluded from commercialization by the proprietary rights of 
others or by competing products or technologies for the same indication.  
Success in preclinical and early clinical trials does not ensure that large 
scale clinical trials will be successful. Clinical results are frequently 
susceptible to varying interpretations which may delay, limit or prevent 
regulatory approvals. The length of time necessary to complete clinical trials 
and from submission of an application for marketing approval to a final 
decision by a regulatory authority varies significantly and may be difficult 
to predict.

Uncertainties surrounding proprietary rights  -  The patent positions of 
pharmaceutical and biotechnology companies can be highly uncertain and involve 
complex legal and factual questions. Accordingly, the breadth of claims 
allowed in such company's patents cannot be predicted. Patent disputes are 
frequent and can preclude commercialization of products. The Company, as in


                                   Page 15

the past, may be involved in future material patent litigation. Such 
litigation is costly in its own right and could subject the Company to
significant liabilities to third parties and, if decided adversely, the 
Company may need to obtain third party licenses or cease using the technology 
or product in dispute. As discussed above, the presence of patents or other 
proprietary rights belonging to other parties may lead to the termination of 
research and development of a particular product.






















































                                   Page 16




                   INDEPENDENT ACCOUNTANTS' REVIEW REPORT



The Board of Directors and Stockholders
Genentech, Inc.


We have reviewed the accompanying condensed consolidated balance sheet of 
Genentech, Inc. as of March 31, 1996, and the related condensed consolidated 
statements of income and cash flows for the three-month periods ended March 
31, 1996 and 1995.  These financial statements are the responsibility of the 
Company's management.

We conducted our reviews in accordance with standards established by the 
American Institute of Certified Public Accountants.  A review of interim 
financial information consists principally of applying analytical procedures 
to financial data, and making inquiries of persons responsible for financial 
and accounting matters.  It is substantially less in scope than an audit 
conducted in accordance with generally accepted auditing standards, which will 
be performed for the full year with the objective of expressing an opinion 
regarding the financial statements taken as a whole.  Accordingly, we do not 
express such opinion.

Based on our reviews, we are not aware of any material modifications that 
should be made to the accompanying condensed consolidated financial statements 
referred to above for them to be in conformity with generally accepted 
accounting principles.

We have previously audited, in accordance with generally accepted auditing 
standards, the consolidated balance sheet of Genentech, Inc. as of December 
31, 1995, and the related consolidated statements of income, stockholders' 
equity, and cash flows for the year then ended (not presented herein) and in 
our report dated January 17, 1996, we expressed an unqualified opinion on 
those consolidated financial statements.  In our opinion, the information set 
forth in the accompanying condensed consolidated balance sheet as of December 
31, 1995, is fairly stated, in all material respects, in relation to the 
consolidated balance sheet from which it has been derived.





                                             ERNST & YOUNG LLP

San Jose, California 
April 9, 1996













                                    Page 17



                                 GENENTECH, INC.
                           PART II.  OTHER INFORMATION


ITEM 1.     LEGAL PROCEEDINGS

On February 26, 1996, the U.S. Court of Appeals for the Federal Circuit 
overruled the preliminary injunction against Novo Nordisk A/S and certain of 
its affiliates (Novo). On April 8, 1996, the same court upheld the preliminary 
injunction against Biotechnology General Corporation and its affiliate (BTG). 
Future court decisions will determine whether Novo's and BTG's growth hormone 
products will be preliminarily or permanently enjoined from the U.S. market.

See also Note 4 "Legal Proceedings" in Part I "Notes to Condensed Consolidated 
Financial Statements."



ITEM 6.     EXHIBITS AND REPORTS ON FORM 8-K

            (a)  Exhibits

                 10.20  Employment Agreement, dated January 1, 1996, between
                          the Company and Edmon R. Jennings

                 15.1   Letter re:   Unaudited Interim Financial Information

                 27.1   Financial Data Schedule

            (b)  Reports on Form 8-K


In a report filed on Form 8-K dated February 23, 1996, in connection with the 
"safe harbor" provisions of the Private Securities Litigation Reform Act of 
1995, the Company made a cautionary statement identifying important factors 
that could cause the Company's actual results to differ materially from those 
projected in forward looking statements made by, or on behalf of, the Company.
























                                     Page 18



                                GENENTECH, INC.
                                  SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned thereunto duly authorized.


   Date:   May 15, 1996                          GENENTECH, INC.


   /S/ARTHUR D. LEVINSON                         /S/LOUIS J. LAVIGNE, JR.
   -------------------------------------         ----------------------------
   Arthur D. Levinson, Ph.D.                     Louis J. Lavigne, Jr.
   President and Chief Executive Officer         Senior Vice President and
                                                 Chief Financial Officer



                                                 /S/BRADFORD S. GOODWIN
                                                 ----------------------------
                                                 Bradford S. Goodwin
                                                 Vice President and Controller




































                                      Page 19






<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS INCLUDED IN THE COMPANY'S FORM 10-Q
FOR THE PERIOD ENDED MARCH 31, 1996, AND IS QUALIFIED IN ITS ENTIRETY BY 
REFERENCE TO SUCH FINANCIAL STATEMENTS AND THE NOTES THERETO.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-END>                               MAR-31-1996
<CASH>                                         138,880
<SECURITIES>                                 1,008,933
<RECEIVABLES>                                  174,865<F1>
<ALLOWANCES>                                         0<F1>
<INVENTORY>                                     88,853
<CURRENT-ASSETS>                             1,064,397
<PP&E>                                         796,015
<DEPRECIATION>                                 281,554
<TOTAL-ASSETS>                               2,065,668
<CURRENT-LIABILITIES>                          224,377
<BONDS>                                        150,000
                                0
                                          0
<COMMON>                                         2,403
<OTHER-SE>                                   1,662,909
<TOTAL-LIABILITY-AND-EQUITY>                 2,065,668
<SALES>                                        152,337
<TOTAL-REVENUES>                               242,884
<CGS>                                           25,879
<TOTAL-COSTS>                                   25,879
<OTHER-EXPENSES>                               115,633
<LOSS-PROVISION>                                     0<F1>
<INTEREST-EXPENSE>                               1,559
<INCOME-PRETAX>                                 47,771
<INCOME-TAX>                                     9,554
<INCOME-CONTINUING>                             38,217
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                    38,217
<EPS-PRIMARY>                                      .31
<EPS-DILUTED>                                        0
<FN>
<F1>ACCOUNTS RECEIVABLE ARE PRESENTED NET OF ALLOWANCE FOR DOUBTFUL ACCOUNTS IN
THE CONDENSED CONSOLIDATED BALANCE SHEET.  THE PROVISION FOR LOSSES ON DOUBTFUL
ACCOUNTS IS NOT REPORTED AS A SEPARATE LINE IN THE CONDENSED CONSOLIDATED
STATEMENT OF INCOME OR STATEMENT OF CASH FLOWS. 
</FN>
        

</TABLE>


Exhibit 15.1


May 14, 1996


Securities and Exchange Commission
Washington, DC  20549

We are aware of the incorporation by reference in the Registration 
Statements pertaining to the 1991 Employee Stock Plan, the 1994 Stock 
Option Plan, the 1990 Stock Option/Stock Incentive Plan, the 1984 Incentive 
Stock Option Plan and the 1984 Non-Qualified Stock Option Plan, the shares 
issuable to certain warrant holders, the shares issuable to certain 
convertible subordinated debenture holders, the Genentech, Inc. Tax 
Reduction Investment Plan and in the related prospectuses, as applicable, 
contained in such Registration Statements of our report dated April 9, 1996 
relating to the unaudited condensed consolidated interim financial 
statements of Genentech, Inc. which are included in its Form 10-Q for the 
quarter ended March 31, 1996.

Pursuant to Rule 436(c) of the Securities Act of 1933 our report is not a 
part of the registration statement prepared or certified by accountants 
within the meaning of Section 7 or 11 of the Securities Act of 1933.


                                             Very truly yours,




                                             ERNST & YOUNG LLP





                             EMPLOYMENT AGREEMENT

     EMPLOYMENT AGREEMENT effective as of this 1st day of January 1996 
("Effective Date"), by and between Genentech, Inc., a Delaware corporation, 
hereinafter called the "Company" and Edmon R. ("Ed") Jennings, an individual, 
hereinafter called the "Employee."

                                 WITNESSETH:

     WHEREAS, the Company believes, and has heretofore acknowledged, that the 
Employee has made a tremendous contribution to the Company and is a highly 
valued employee, and accordingly the Company wishes to formalize its long-
standing relationship with the Employee by documenting its desire to continue 
to employ the Employee as its Vice President; and 

     WHEREAS, Employee is desirous of providing services to the Company in the 
aforementioned capacity:

     NOW, THEREFORE, in consideration of the mutual promises contained below, 
the Company and the Employee hereby agree as follows:

     1.  Employment.  The Company hereby employs the Employee and the Employee 
hereby accepts employment upon the terms and conditions set forth herein.

     2.  Term.  Subject to the provisions for early termination of the 
Employee's employment as hereinafter provided, the term of this Employment 
Agreement shall commence as of the Effective Date and shall continue for a 
period of three (3) years thereafter (the "Term").

     3.  Duties.  During the Term, Employee shall be employed as a Vice 
President of the Company and shall carry out the duties of said position in 
accordance with the reasonable directions and assignments of his superiors.  
The Employee agrees to exercise his best efforts to advance the interests of 
the Company, to diligently carry out the duties assigned to him by the Company 
and to devote his full-time attention and energies to the business of the 
Company.  The Employee will not, during the Term, engage in any other business 
activity inconsistent with his duties to the Company.

     4.  Salary.  For all services rendered by the Employee hereunder, the 
Company agrees to pay annually to the Employee a base salary of one hundred 
ninety nine thousand eight hundred dollars ($199,800) (inclusive of the 
Employee's car allowance), payable in equal semi-monthly installments ("Base 
Salary"), which amount shall be reviewed on an annual basis and may be subject 
to upward adjustment on the basis of performance consistent with upward 
adjustments for the salaries of Vice Presidents of the Company generally as 
well as those whose scope of duties and responsibilities are similar to 
Employee's.  The Employee will next be eligible for a salary review in 
December, 1996.  During the period of his employment, the Employee shall also 
receive the benefits referred to in Paragraph 6 (b), without the exclusion 
resulting from consultant status.

     5.  Bonuses.  In addition to the salary set forth in Paragraph 4, the 
Employee is eligible to receive cash bonuses each year during the Term hereof, 
consistent with the Company's bonus plan for that year as approved by the 
Company's Board of Directors and similar in amount to bonuses paid other Vice 
Presidents of the Company whose scope of duties and responsibilities are 
similar to Employee's.

     6.  Termination.  

        (a)  The employment of the Employee hereunder may be terminated at any 
time, for any reason, by either party upon two weeks' notice of termination to 
the other party.

        (b)  In the event of such termination by either party (except for 
termination by the Company for cause, as described in Paragraph 6(c) below), 
Employee shall continue as a consultant to the Company for the remainder of 
the Term, and the Company shall pay to Employee as a consultant on a monthly 
basis, within 15 days of the end of each month, during each month of the 
remaining Term, an amount equal to the amount of salary paid during his last 
month as an employee plus 1/12th of the amount of bonus he received for the 
preceding year.  The foregoing amounts shall be subject to any appropriate 
withholding for federal or state income tax or similar tax purposes.  In 
addition, in the event of such termination, Employee shall continue to 
receive, while he is receiving any payment under this paragraph, benefits 
similar to those that are then available to employees of the Company at the 
Vice President level, including, without limitation, medical, dental, vision 
and insurance benefits and any other benefits but specifically excluding the 
Company's stock purchase plan, its 401(k) plan and any other plan the Company 
may adopt in which participation is specifically conditioned on status as an 
employee.  In addition, in the event of such termination, Employee as a 
consultant shall continue during the remaining Term to vest any unvested stock 
options he has under any of the Company's stock option plans at the same  rate 
such options are vesting as of the Effective Date and such stock options shall 
remain exercisable until March 30, 2000, unless earlier terminated by lapse of 
time pursuant to the provisions of the plan or plans under which the stock 
options were granted.  If Roche exercises its option to cause the Company to 
redeem all of the outstanding common stock not then owned by Roche, vesting of 
Employee's unvested options shall accelerate to the extent provided under the 
stock option plans and the individual grant agreements pursuant to which the 
options were granted, and the unvested options shall otherwise be treated in a 
manner identical to that of the unvested options (from the same stock option 
plans) of the Company's other employees at that time.  In the event of a 
termination as described in Paragraph 6(a), Employee and the Company shall 
enter into a consulting agreement which contains the material terms described 
herein and any other standard terms the Company imposes on its other 
consultants at the time of such agreement.

        (c)  The Company shall have the right to terminate this Agreement for 
cause only under the following circumstances: 

          (i)  the Employee's willful and continuing gross neglect of his
               duties or his willful and continuing failure to perform his
               duties, which continues for more than thirty (30) days 
               following the Employee's receipt of written notice from the
               Company that describes such gross neglect or failure,  

         (ii)  the Employee's breach of his confidentiality obligations
               to the Company, as described in the Proprietary Rights and
               Inventions Agreement between the parties; or

        (iii)  the Employee's embezzlement from or fraud against the Company.

In the event of a termination for cause by the Company, and only in such 
event, the Employee shall only be paid his salary due as of his last day of 
employment and shall receive no benefits provided in Paragraph 6(b) hereof or 
any other compensation or remuneration hereunder.  Nothing in Paragraph 
6(c)(i) shall be construed as prohibiting the Employee from voluntarily 
resigning his position during the 30-day notice period provided in paragraph 
6(c)(i) or at any time prior to the Employee's receipt of such notice.  In 
such case, the Employee shall receive the benefits described in Paragraph 6(b) 
hereof.

     7.  Waiver and Release.  (a) Subject to the provisions of Paragraph 7(b) 
below, in exchange for the benefits provided to the Employee in this 
Agreement, the Employee waives and releases and promises never to assert any 
and all claims that the Employee has or might have against the Company and its 
predecessors, subsidiaries, related entities, officers, directors, 
shareholders, agents, attorneys, employees, successors or assigns arising out 
of any acts, omissions or events occurring prior to the Effective Date, and 
other than claims arising under this Agreement.  These claims include, but are 
not limited to, claims for discrimination arising under federal, state and 
local statutory or common law such as the Age Discrimination in Employment 
Act, Title VII of the Civil Rights Act of 1964, the California Fair Employment 
and Housing Act, the Americans with Disabilities Act, and the law of contract 
and tort. The Employee also waives and releases and promises never to assert 
any such claims, even if the Employee does not believe that he has such 
claims.  The Employee therefore waives his rights under section 1542 of the 
Civil Code of California, which states as follows:

               A general release does not extend to claims which
            the creditor does not know or suspect to exist in his
            favor at the time of executing the release, which if
            known by him must have materially affected his 
            settlement with the debtor.

     (b)  Notwithstanding the provisions of Paragraph 7(a) above:

          (i)  if the Employee shall hereafter be made a defendant in any
               civil or criminal proceeding or proceedings relating to the
               Employee's activities as an employee of, or otherwise on behalf
               of, the Company, and whether or not such activities have 
               heretofore been or may hereafter be the subject of governmental
               or other investigation, inquiry or other action, and/or

         (ii)  if the Employee shall otherwise be subjected to expense or
               other liability in connection with any such activities, 
               investigation, inquiry or other action,

then (A) the Waiver and Release provided for in Paragraph 7(a) shall not apply 
to claims of the Employee against the Company for indemnification which arise 
out of any of the matters referred to in (b)(i) or (b)(ii) above ("Potential 
Matters"), and (B) the Company agrees to indemnify the Employee fully with 
respect to any and all Potential Matters in accordance with the Company's 
Certificate of Incorporation and the Delaware (or other relevant) corporate 
law, including but not limited to the same provisions with respect to 
indemnification and advancement of such legal fees which the Employee may 
incur in connection with any such Potential Matter as are contained in the May 
31, 1994 agreement between the Employee and the Company.

     8.  Choice of Law; Arbitration.  This Employment Agreement shall be 
interpreted and enforced in accordance with the laws of the State of 
California.  Any dispute under this Agreement shall be resolved by 
arbitration, which shall be held in San Francisco, California, in accordance 
with the Rules of the American Arbitration Association, within thirty (30) 
days after the parties shall have been unable to resolve any such dispute.  
Judgment upon an arbitration award may be entered in any court of competent 
jurisdiction.  The prevailing party shall be entitled to reasonable attorney's 
fees in addition to any other relief to which such party may be entitled.

     9.  Notices.  Any notice required or permitted to be given under this 
Employment Agreement shall be sufficient if in writing, and if sent by first 
class mail to his residence in the case of the Employee, or to its principal 
office in the case of the Company and addressed to Corporate Secretary.  Any 
such notice shall be effective upon delivery if it is hand-delivered, upon 
receipt if it is transmitted by wire or telegram, or three (3) days after 
deposit in the United States mail, if it is mailed.

    10.  Waiver of Breach.  The waiver by either party of a breach of any 
provision of this Employment Agreement by the other party shall not operate or 
be construed as a waiver of any subsequent breach by such other party.

    11.  Assignment.  The rights and obligations of the Company under this 
Employment Agreement shall inure to the benefit of and shall be binding upon 
the successors and assigns of the Company.  The Company may assign this 
Agreement to any purchaser of substantially all of its assets, to the 
surviving entity in a merger with the Company, or to any entity controlled by, 
under common control with, or controlling the Company.  Employee shall have no 
right or power to assign this Agreement in whole or in part to any third 
party, provided, however, that:

     (a)  if the Employee shall be prevented during the term of this Agreement
          from properly performing services hereunder by reason of illness or
          other physical or mental incapacity, the Company shall continue to 
          pay the Employee his then current salary hereunder during the period
          of his disability (but not to exceed the Term) and shall continue to
          provide all of the employee benefits to which the Employee was 
          entitled prior to the commencement of such disability;

     (b)  the provisions of this Paragraph 11 shall not affect the 
          entitlements of the Employee's spouse, heirs, executors,
          administrators, legatees, beneficiaries or assigns under the 
          Company's Stock Purchase or Stock Option Plan, or any other employee
          benefit plan of the Company.

    12.  Entire Agreement.  This Employment Agreement contains the entire 
agreement of the parties respecting the subject matter hereof, but does not 
abrogate or otherwise affect the May 31, 1994 agreement between the Company 
and the Employee concerning indemnification of the Employee.  This Employment 
Agreement may not be changed orally but only by an agreement in writing 
executed by both of the parties.

     IN WITNESS WHEREOF,  parties have executed this Employment Agreement 
effective as of the Effective Date.

                                          COMPANY:

                                          By:        /S/John P. McLaughlin

                                          Title:     Executive Vice President

                                          EMPLOYEE:  /S/Edmon R. Jennings





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