GENENTECH INC
10-K, 1997-03-27
PHARMACEUTICAL PREPARATIONS
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                                UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                  Form 10-K

(Mark One)
X      ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934
       For the fiscal year ended December 31, 1996

       TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES
       EXCHANGE ACT OF 1934
       For the transition period from   to   .

                    Commission file number: 1-9813

                             GENENTECH, INC.

     A Delaware Corporation                         94-2347624
                                       (I.R.S. employer identification number)

460 Point San Bruno Boulevard                      
South San Francisco, California  94080-4990       
(415) 225-1000

Securities registered pursuant to Section 12(b) of the Act:
==============================================================================
  Title of Each Class                Name of Each Exchange on Which Registered
- ------------------------------------------------------------------------------
Common Stock $.02 par value                 New York Stock Exchange
Callable Putable Common Stock               Pacific Stock Exchange
$.02 par value
==============================================================================
Indicate by check mark whether the registrant (1) has filed all reports 
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period that the 
registrant was required to file such reports), and (2) has been subject to 
such filing requirements for the past 90 days.  Yes  X    No

Indicate by check mark if disclosure of delinquent filers pursuant to Item 
405 of Regulation S-K is not contained herein, and will not be contained, to 
the best of registrant's knowledge, in definitive proxy or information 
statements incorporated by reference in Part III of this Form 10-K or any 
amendment to this Form 10-K.  [   ]

The approximate aggregate market value of voting stock held by nonaffiliates 
of the registrant is $2,124,378,536 as of March 7, 1997. (A)

Number of shares of Common Stock outstanding as of March 7, 1997:  
   76,621,009
Number of shares of Callable Putable Common Stock outstanding as of 
   March 7, 1997:   45,537,468

             Documents incorporated by reference:
                                                          PARTS INCORPORATED
                       DOCUMENT                               BY REFERENCE

(1) Annual Report to stockholders for the year ended                 II
    December 31, 1996 (specified portions)

(2) Definitive Proxy Statement with respect to the 1997             III
    Annual Meeting of Stockholders filed by Genentech, Inc. 
    (SEC file No. 1-9813) with the Securities and Exchange 
    Commission (hereinafter referred to as "Proxy Statement")
- -----------------------------------------------------------------------------
(A) Excludes 92,659,682 shares of Common Stock and Callable Putable Common 
Stock held by Directors, Officers and stockholders whose ownership exceeds 
five percent of either the Common Stock or Callable Putable Common Stock 
outstanding at March 7, 1997 (the holdings of one stockholder, FMR Corp., 
were calculated based on its holdings as of December 31, 1996).  Exclusion of 
shares held by any person should not be construed to indicate that such 
person possesses the power, direct or indirect, to direct or cause the 
direction of the management or policies of the registrant, or that such 
person is controlled by or under common control with the registrant.

                                     PART I
ITEM 1.   BUSINESS

Genentech, Inc. (the Company) is a biotechnology company that discovers, 
develops, manufactures and markets human pharmaceuticals produced by 
recombinant DNA technology for significant unmet medical needs.  The Company 
manufactures and markets six products directly in the United States (U.S.) and 
sells these products to F. Hoffmann-La Roche Ltd (HLR) for HLR to sell outside 
of the United States.  Of these six products, HLR has the right to sell five 
in Canada and one in a number of countries.  In addition, the Company receives 
royalties from HLR's sales of these products and receives royalties from HLR 
and other licensees from sales of five other products which originated from 
the Company's technology.

RELATIONSHIP WITH ROCHE HOLDINGS, INC.

On October 25, 1995, the Company and Roche Holdings, Inc. (Roche) entered into 
a new agreement (the Agreement).  Each share of the Company's common stock not 
held by Roche or its affiliates on that date automatically converted to one 
share of callable putable common stock (special common stock).  The Agreement 
extends until June 30, 1999, Roche's option to cause the Company to redeem 
(call) the outstanding special common stock of the Company at predetermined 
prices. Should the call be exercised, Roche will concurrently purchase from 
the Company a like number of common shares, for a price equal to the Company's 
cost to redeem the special common stock. During the quarter beginning January 
1, 1997, the call price is $69.25 per share; it increases by $1.25 in the 
following quarter, then increases by $1.50 per share each quarter through the 
end of the option period on June 30, 1999, on which date the price is $82.50 
per share.  If Roche does not cause the redemption as of June 30, 1999, the 
Company's stockholders will have the option (the put) to cause the Company to 
redeem none, some, or all of their shares of special common stock at $60.00 
per share (and Roche will concurrently provide the necessary redemption funds 
to the Company by purchasing a like number of shares of common stock at $60.00 
per share) within thirty business days commencing July 1, 1999.  Roche Holding 
Ltd, a Swiss corporation, has guaranteed Roche's obligation under the put.

In conjunction with the Agreement, HLR was granted an option for ten years for 
licenses to use and sell certain of the Company's products in non-U.S. markets. 
As a general matter, such option for a Genentech product must be exercised at, 
or prior to if Genentech mutually agrees, the conclusion of phase II clinical 
trials for each product.  In general, for each product for which HLR exercises 
its option, the Company and HLR will share equally all development expenses 
incurred by the Company through the option exercise date and prospectively with 
respect to the development of the product in the United States. HLR will pay 
all non-U.S. development expenses.  At the Company's election, and with HLR's 
consent, HLR may reimburse the Company for HLR's share of development costs 
incurred prior to HLR's option exercise date, either by payment of such costs 
at the time of the option exercise or by making payments prospectively until 
HLR's share has been fully reimbursed to the Company.

In general, HLR pays a royalty of 12.5% until a product reaches $100 million 
in aggregate sales outside of the U.S., at which time the royalty rate 
increases to 15%. In addition, HLR has exclusive rights to, and pays the 
Company 20% royalties on, Canadian sales of the Company's existing products 
and European sales of Pulmozyme, registered trademark.  Consequently, in the 
fourth quarter of 1995, the Company transferred to HLR the rights to its 
Canadian product sales and European sales of Pulmozyme, and commenced 
recording royalty revenue from HLR on such sales.  The Company supplies its 
products to HLR, and has agreed to supply products for which HLR has exercised 
its option, for sales outside of the U.S. at cost plus 20%.

Under the Agreement, independent of its right to cause the Company to redeem 
the special common stock, Roche may increase its ownership of the Company up 
to 79.9% by making purchases on the open market.  Roche held approximately 
66.0% of the outstanding common equity of the Company as of December 31, 1996. 
In January and February 1997, Roche purchased additional shares of the 
Company's common equity, thereby increasing Roche's holdings to approximately 
68.0%.

Roche and the Company have developed "Guiding Principles" regarding the nature 
of their relationship should the call rights be exercised by Roche or the put 
rights be exercised by the Company's stockholders.  These Guiding Principles 
are not binding on either of the companies and are not intended to modify or 
alter in any manner any of the agreements between Roche and the Company or to 
waive any rights that either Roche or the Company may have under such 
agreements.  These Guiding Principles reflect certain of the current practices 
of the Company or how the Company and Roche will interact in certain business 
areas if the put rights or call rights are exercised.

Products

Genentech has developed and currently manufactures and markets six products in 
the U.S.: Activase, registered trademark, (Alteplase, recombinant) recombinant 
tissue plasminogen activator; Protropin, registered trademark, (somatrem for 
injection) recombinant growth hormone; Nutropin, registered trademark, 
[somatropin (rDNA origin) for injection] human growth hormone; Nutropin AQ, 
trademark, [somatropin (rDNA origin) injection] liquid formulation human 
growth hormone; Pulmozyme, (dornase alfa) inhalation solution; and Actimmune, 
registered trademark, (Interferon gamma-1b) recombinant interferon gamma. 

Activase:  Tissue plasminogen activator (t-PA) is an enzyme that is produced 
naturally by the body to dissolve blood clots.  However, when a blood clot 
obstructs blood flow in the coronary artery and causes a heart attack, the 
body is unable to produce enough t-PA to dissolve the clot rapidly enough to 
prevent damage to the heart.  Through recombinant DNA technology, Genentech 
produces Activase, a recombinant form of t-PA, in sufficient quantity for 
therapeutic use.  The United States Food and Drug Administration (FDA) 
approved Activase for marketing in the U.S. in 1987 for the treatment of acute 
myocardial infarction (AMI or heart attack); in 1990 for use in the treatment 
of acute pulmonary embolism (blood clots in the lungs); and in June 1996 for 
the treatment of acute ischemic stroke or brain attack within three hours of 
symptom onset.  The Company is currently conducting Phase III studies to 
expand the treatment window to five hours from symptom onset in patients with 
acute ischemic stroke.  In addition, Phase II studies are being performed to 
evaluate a second generation of t-PA. 

In exchange for royalty payments, the Company has licensed marketing rights to 
recombinant t-PA in Japan to Kyowa Hakko Kogyo, Ltd. (Kyowa) and Mitsubishi 
Kasei Corporation (Mitsubishi).  Kyowa and Mitsubishi are marketing forms of 
recombinant t-PA under the trademarks Activacin, registered trademark, and 
GRTPA, registered trademark, respectively.  In a number of countries outside 
of the U.S., Canada and Japan, the Company has licensed t-PA marketing and 
manufacturing rights to Boehringer Ingelheim International GmbH (Boehringer).  
The Company has also licensed certain rights to Boehringer regarding future 
sales of the second generation of t-PA, which is currently under development.  
Boehringer markets recombinant t-PA under the trademark Actilyse, registered 
trademark.  Prior to February 1995, t-PA was marketed in Canada by the Company 
under the Activase trademark and by Boehringer under the trademark Lysatec.  
In February 1995, the Company purchased all t-PA Canadian marketing rights 
from Boehringer.  Pursuant to the Agreement with Roche, the Company 
subsequently granted exclusive rights to HLR, which began selling Activase in 
Canada on December 1, 1995, and the Company began receiving a royalty on such 
sales.

Protropin:  Human growth hormone is a naturally occurring human protein 
produced in the pituitary gland that regulates metabolism and is responsible 
for growth in children.  A recombinant growth hormone product developed by the 
Company, Protropin, was approved by the FDA in 1985 for marketing in the U.S. 
for the treatment of growth hormone inadequacy in children.

In exchange for royalty payments, the Company licensed rights to recombinant 
growth hormone outside the U.S. and Canada to Pharmacia & Upjohn, which 
manufactures and markets recombinant growth hormone under the trademarks 
Somatonorm, registered trademark, and Genotropin, registered trademark.  Under 
the terms of the agreement with Pharmacia & Upjohn, and effective in late 
1995, the Company now has the right to sell growth hormone in certain European 
countries and Pharmacia & Upjohn has the right to sell their own growth 
hormone in the U.S. and Canada.  In conjunction with the Agreement with Roche, 
Genentech granted exclusive rights to sell Protropin in Canada to HLR, which 
began selling Protropin in Canada on December 1, 1995, and Genentech began 
receiving a royalty on such sales.

Nutropin:  Nutropin is a human growth hormone similar to Protropin; however, 
it does not have the additional amino acid, methionine, found in the Protropin 
chemical structure. It was approved by the FDA in March 1994 for marketing for 
the treatment of growth hormone inadequacy in children. Nutropin was approved 
in November 1993 and launched in January 1994 for marketing in the U.S. for 
the treatment of growth hormone inadequacy in children due to chronic renal 
insufficiency (CRI). CRI causes irreversible damage to the kidneys and a 
variety of other medical problems, including growth hormone inadequacy.  The 
condition affects an estimated 3,000 children in the United States.  Nutropin 
has been designated an Orphan Drug for treatment of growth hormone inadequacy 
in children with CRI in the United States. In December 1996, the FDA approved 
Nutropin for the treatment of short stature associated with Turner syndrome. 
The Company has also applied for regulatory approval of Nutropin for growth 
hormone inadequacy in adults.  In conjunction with the Agreement with Roche, 
the Company granted the right to sell Nutropin in Canada to HLR, and the 
Company will receive a royalty on any such sales.

Nutropin AQ:  In December 1995, the Company received regulatory approval to 
market Nutropin AQ, a liquid formulation of Nutropin, aimed at providing 
improved convenience in administration.  Nutropin AQ was approved for the 
treatment of growth hormone inadequacy in children, growth hormone inadequacy 
in children due to CRI and short stature associated with Turner syndrome.  HLR 
has the right to sell Nutropin AQ in Canada from which the Company will 
receive a royalty on any such sales.

In addition, the Company is working in collaboration with Alkermes, Inc. to 
develop a sustained-release formulation of the Company's human growth hormone. 
Currently in Phase I/II clinical trials, this formulation is designed to free 
patients receiving growth hormone therapy from the need for daily injections.

Pulmozyme:  Pulmozyme is marketed in the U.S. for the management of cystic 
fibrosis (CF), for which it has U.S. Orphan Drug designation.  There are an 
estimated 22,000 patients with CF in the U.S., a significant portion of whom 
are expected to be candidates for treatment.  In December 1996, Pulmozyme was 
cleared for marketing by the FDA for the management of CF patients with 
advanced disease.  Phase III studies are being performed to determine whether 
early intervention with Pulmozyme can benefit young patients with preserved 
lung function.  In conjunction with the Agreement with Roche, and effective 
during the fourth quarter of 1995, the Company granted Roche the exclusive 
right to sell Pulmozyme in Europe and Canada in return for a royalty on such 
sales.

Actimmune:  Actimmune is approved in the U.S. for the treatment of chronic 
granulomatous disease (CGD), a rare, inherited disorder of the immune system 
which affects an estimated 250 to 400 Americans.  Actimmune received 
designation by the FDA in 1990 as an Orphan Drug for the treatment of CGD in 
the United States.  The Company receives royalty payments from Boehringer from 
the sale of interferon gamma in certain countries outside of the U.S., Canada 
and Japan.




Licensed Products:  

In addition to the royalties mentioned above, the Company also receives 
royalties on the following products:

         Product                 Trademark              Company
____________________________    ____________  ______________________________
Recombinant human insulin        Humulin      Eli Lilly and Company (Lilly)
Human growth hormone             Humatrope    Lilly 
Recombinant interferon alpha     Roferon-A    HLR
Hepatitis B vaccine              Recombivax   Merck and Company, Inc.
Hepatitis B vaccine              Engerix-B    Smith-Kline Beecham 
                                                Pharmaceuticals 
Factor VIII                      Kogenate     Bayer Corporation
Bovine growth hormone            Posilac      Monsanto Corporation


Royalty payments from Lilly on Humulin, trademark, sales will expire in August 
1998. In December 1994, the Company and Lilly reached an agreement regarding 
all patent infringement and contract actions then pending between the two 
parties. Under the terms of the settlement, Lilly agreed to pay the Company up 
to $145 million ($25 million in 1994, and 16 quarterly payments of $7.5 
million thereafter, $30.0 million of which was received and recorded as 
revenue by Genentech in each of 1996 and 1995), subject to possible offsets 
and contingent upon Humulin  continuing to be marketed in the United States.  
In return, the Company granted Lilly licenses, options to licenses, or 
immunities from suit for certain of the Company's patents. Future payments are 
required from Lilly on sales of these products.  These future payments from 
Lilly will expire at the end of 1998.

Through its January 1997 agreement with Roche Laboratories, Inc., a New Jersey 
corporation, the Company now has the exclusive right to market and promote 
Roche's Roferon-A, registered trademark, in the U.S. for ten years for its 
approved oncology indications, including hairy-cell leukemia, AIDs-related 
Kaposi's sarcoma and Ph-positive chronic myelogenous leukemia.  During the 
term of such agreement, the Company will receive a commission on the net sales 
of Roferon-A, and the Company shall not receive any royalty (other than as 
part of the commission) under the 1980 Roche agreement regarding such sales.

Products in Development:  As part of the Company's program of research and 
development (R&D), a number of other products are in various stages of 
development.  Product development efforts cover a wide range of disorders or 
medical conditions, including cancer, respiratory disorders, cardiovascular 
diseases, endocrine disorders, inflammatory and immune problems, and 
neurological disorders.

In addition to the new indications for existing products discussed above, 
below is a summary of products in clinical development:

<TABLE>
<CAPTION>
Product                             Description
- --------------------------------    ------------------------------------------------
<S>                                 <C>  
Phase III
- ---------
Anti-HER2 Humanized Monoclonal      A humanized monoclonal antibody targeted against
  Antibody                          a protein receptor, which may be useful in the
                                    treatment of certain types of breast cancer.

Auriculin (registered trademark)    A hormone that occurs naturally in the heart 
  Anaritide                         which may be useful in treating oliguric
                                    patients with acute renal failure (being
                                    developed under a collaboration between the
                                    Company and Scios Inc.).

IDEC-C2B8                           A monoclonal antibody which may be useful 
                                    in the treatment of non-Hodgkin's B-cell 
                                    lymphomas (being developed under a collaboration
                                    between the Company and IDEC Pharmaceuticals, Inc.,
                                    (IDEC) and under a collaboration between the Company
                                    and Roche).  IDEC filed for regulatory approval
                                    in the first quarter of 1997.

IGF-I                               A protein that is being studied to determine if
                                    it can improve blood glucose control in type I
                                    and II diabetics.  The Company is currently 
                                    preparing for phase III clinical trials for type
                                    II diabetics.  (Roche has exercised its option
                                    for this product outside of the U.S.)

Nerve Growth Factor                 A protein that may aid the treatment of diabetic
                                    peripheral neuropathy (Roche has exercised its
                                    option for this product outside of the U.S.).  The
                                    Company is currently preparing for phase III
                                    clinical trials.

Oral IIb/IIIa antagonist            An inhibitor of platelet aggregation that may
                                    be useful in the prevention of unwanted 
                                    clotting in certain cardiovascular conditions
                                    (being developed under a collaboration between
                                    the Company and Roche).  The Company is 
                                    currently preparing for phase III clinical
                                    trials.
Phase II
- --------
Anti-IgE Humanized Monoclonal       A humanized IgE monoclonal antibody designed to
   Antibody                         interfere early in the process that leads to 
                                    symptoms of allergy such as allergic asthma
                                    and allergic rhinitis (being developed in 
                                    collaboration with Tanox Biosystems, Inc. and
                                    Novartis Pharmaceuticals Corporation).

Thrombopoietin (TPO)                A protein that is being studied for treatment of 
                                    thrombocytopenia, a reduction in clot-inducing
                                    platelets, in cancer patients treated with
                                    chemotherapy.
Phase I
- -------
Anti-CD18                           An antibody designed to address problems 
                                    related to loss of blood flow, as in
                                    trauma.  (This is being developed in 
                                    collaboration with Roche.)

Anti-CDIIa                          An antibody designed to block the immune
                                    cells that are over-active in psoriasis.
                                    Preclinical studies suggest it also may 
                                    be useful to curb these same immune cells
                                    after an organ transplant, thus preventing
                                    rejection of the transplant.  (This is 
                                    being developed in collaboration with Xoma
                                    Corporation.)

Vascular Endothelial Growth         A protein that ischemic tissues, tissues
Factor (VEGF)                       lacking in oxygen, secrete.  It binds to
                                    receptors on nearby blood vessels and 
                                    causes angiogenesis, the formation of new
                                    blood vessels.  The Company is currently
                                    investigating the use of VEGF for the
                                    treatment of coronary ischemia.

Anti-VEGF                           An antibody developed to treat several
                                    types of cancer.  In preclinical studies,
                                    the anti-VEGF antibody resulted in 
                                    decreased vascularization and a decline in
                                    growth and metastasis of a variety of
                                    tumors.  The Company has filed an
                                    investigational new drug application (IND)
                                    to investigate its anti-VEGF antibody in a
                                    Phase I clinical trial as a potential
                                    therapy against solid tumors.
</TABLE>


In conjunction with the Agreement with Roche, HLR was granted an option for 
ten years for licenses to use and sell certain of the Company's products in 
non-U.S. markets.  In the past, the Company has licensed the foreign rights to 
some of its products to major foreign pharmaceutical companies and actively 
coordinated development and clinical programs with these partners.  In some 
cases the Company has retained manufacturing rights to the licensed products. 
The Company has retained U.S. marketing rights for its products currently 
under development.

The Company entered into a collaboration with IDEC in March 1995, to develop 
IDEC's anti-CD20 monoclonal antibody, IDEC-C2B8, for the treatment of non-
Hodgkin's B-cell lymphomas.  In the first quarter of 1997, IDEC filed for 
regulatory approval of that product.  In February 1996, the Company expanded 
its collaboration with IDEC to include two radioconjugates, IDEC-Y2B8 and 
IDEC-In2B8, for the treatment of more severe forms of B-cell lymphomas. Under 
the terms of the collaboration agreement, the Company and IDEC have agreed to 
copromote IDEC-C2B8 in the U.S. and Canada, with IDEC receiving a share of the 
profits.  The Company has commercialization rights throughout the rest of the 
world except Japan.  In conjunction with the Agreement with Roche, the Company 
has granted an option to HLR to use and sell IDEC-C2B8 in all countries, 
except the U.S., in which the Company has rights under its agreement with 
IDEC.  HLR exercised that option.  IDEC will receive royalties on sales 
outside the U.S.  In connection with the collaboration, the Company provided 
$9.0 million in preferred equity investments and licensing fees, provided 
additional equity funding of $12.5 million in 1996 and $2.5 million in 1995, 
and will provide up to $29.0 million in milestone and option payments of which 
$4.0 million was paid in 1996.  The Company's equity investment in IDEC at 
December 31, 1996 had a carrying value of $45.6 million.  

The Company has a collaboration with Scios Inc. (Scios) for the development of 
Scios's Auriculin for the treatment of acute renal failure in the U.S. and 
Canada.  The results of the Phase III trial announced in May 1995, were 
equivocal in all primary endpoints with the exception of a prospectively 
defined endpoint relating to oliguric (low urine output) patients.  Scios is 
pursuing another Phase III trial for acute renal failure in relation to this 
sub-population of oliguric patients.  Under terms of the collaboration, the 
companies have agreed to copromote Auriculin in the U.S. and Canada, sharing 
profits from its commercialization.  The Company received exclusive rights to 
all markets outside the U.S. and Canada subject to a royalty obligation to 
Scios.  In connection with the collaboration, the Company purchased Scios non-
voting preferred stock for $20 million, which is convertible into shares of 
Scios common stock.  A portion of this preferred stock was subsequently sold.  
The Company's equity holding in Scios at December 31, 1996, had a carrying 
value of $7.8 million.  The Company established a line of credit for $30 
million that Scios may draw down at Scios's discretion through December 31, 
1997 directly from the bank with immediate repayment of the funds due to the 
bank by the Company.  Amounts drawn by Scios under the bank letter of credit 
or directly from the Company are repayable in the form of cash or Scios common 
stock (at the market price prevailing on the date of repayment) at Scios's 
option any time through December 30, 2002.  Interest on amounts borrowed by 
Scios accrue to the Company at the prime rate of interest.  At December 31, 
1996 and 1995, no amounts were drawn.  In addition, the Company agreed to pay 
$50 million in benchmark payments, conditional on achieving certain 
predetermined commercialization goals.

Distribution

The Company has a U.S.-based pharmaceutical marketing, sales and distribution 
organization for its human pharmaceuticals.  The Company's sales efforts are 
focused on specialist physicians based at major medical centers in the United 
States.  In general, products are sold to distributors or directly to hospital 
pharmacies or medical centers.  The Company utilizes common pharmaceutical 
company marketing techniques, including advertisements, direct mail, and other 
methods.

The Company's products are available at no charge to qualified patients under 
the Company's uninsured patient programs in the United States.  The Company 
has established the Genentech Endowment for Cystic Fibrosis so qualified CF 
patients in the U.S. who need Pulmozyme can gain assistance in obtaining it, 
and the Genentech Endowment for Growth Disorders, so qualified growth hormone 
disorder patients in the U.S. who need Nutropin/Protropin can gain assistance 
in obtaining it.

During 1996, the Company provided certain marketing programs relating to 
Activase.  A comprehensive wastage replacement program exists for Activase 
which, subject to specific conditions, provides customers the right to return 
Activase to the Company for replacement related to both patient related 
product wastage and product expiry.  The Company maintains the right to renew, 
modify or discontinue the above programs.

As discussed in the "Notes to Consolidated Financial Statements" in the 
Company's 1996 Annual Report to Stockholders (Part II, Item 8 of the Form 
10-K), the Company has three customers, including HLR, who provided over 10% 
of total revenues. Also discussed in the note are revenues from foreign 
customers in 1996, 1995 and 1994.

Raw Materials

Raw materials and supplies required for the production of the Company's 
principal products are generally available in quantities adequate to meet the 
Company's needs.

Proprietary Technology - Patents and Trade Secrets

The Company has a policy of seeking patents on inventions arising from its 
ongoing R&D activities.  Patents issued or applied for cover inventions 
ranging from basic recombinant DNA techniques to processes relating to 
specific products and to the products themselves.  The Company has either been 
granted patents or has patent applications pending which relate to a number of 
current and potential products including products licensed to others.  The 
Company considers that in the aggregate its patent applications, patents and 
licenses under patents owned by third-parties are of material importance to 
its operations.  Important legal issues remain to be resolved as to the extent 
and scope of available patent protection for biotechnology products and 
processes in the U.S. and other important markets outside of the United 
States.  The Company expects that litigation will likely be necessary to 
determine the validity and scope of certain of its proprietary rights.  The 
Company is currently involved in a number of patent lawsuits, as either a 
plaintiff or defendant, and administrative proceedings relating to the scope 
of protection of its patents and those of others.  These lawsuits and 
proceedings may result in a significant commitment of Company resources in the 
future.  There can be no assurance that the patents the Company obtains or the 
unpatented proprietary technology it holds will afford the Company significant 
commercial protection.

In general, the Company has obtained licenses from various parties which it 
deems to be necessary or desirable for the manufacture, use or sale of its 
products.  These licenses (both exclusive and non-exclusive) generally require 
the Company to pay royalties to the parties on product sales.

The Company's trademarks, ACTIVASE, PROTROPIN, NUTROPIN, NUTROPIN AQ, 
PULMOZYME and ACTIMMUNE in the aggregate are considered to be of material 
importance and are registered, except Nutropin AQ, in the United States Patent 
and Trademark Office and in other countries throughout the world.

Royalty income recognized by the Company during 1996, 1995 and 1994 for patent 
licenses, know-how and other related rights amounted to $214.7 million, $190.8 
million and $126.0 million, respectively.  In 1996, 1995 and 1994 the Company 
incurred royalty expenses amounting to $58.9 million, $54.8 million and $50.5 
million, respectively, under licenses from others.  

Competition

The Company faces competition, and believes significant long-term competition 
can be expected, from large pharmaceutical and chemical companies as well as 
biotechnology companies.  This competition can be expected to become more 
intense as commercial applications for biotechnology products increase.  Some 
competitors, primarily large pharmaceutical companies, have greater clinical, 
regulatory and marketing resources and experience than the Company.  Many of 
these companies have commercial arrangements with other companies in the 
biotechnology industry to supplement their own research capabilities.

The introduction of new products or the development of new processes by 
competitors or new information about existing products may result in price 
reductions or product replacements, even for products protected by patents.  
However, the Company believes its competitive position is enhanced by its 
commitment to research leading to the discovery and development of new 
products and manufacturing methods.  Other factors which should help the 
Company meet competition include ancillary services provided to support its 
products, customer service, and dissemination of technical information to 
prescribers of its products and to the health care community including payers.

Over the longer term, the Company's (and its partners') ability to 
successfully market current products, expand their usage and bring new 
products to the marketplace will depend on many factors, including the 
effectiveness and safety of the products, FDA and foreign regulatory 
agencies' approvals for new indications, the degree of patent protection 
afforded to particular products, and the effect of the advent of managed care 
as an important purchaser of pharmaceutical products. 

Activase:  Activase's market share in 1996 increased to approximately 80% in 
the U.S. for the treatment of AMI.  However, the overall size of the 
thrombolytic market at year end 1996 declined from 1995 by approximately 6%. 
The decline in the market size was the result of the increasing use of 
angioplasty rather than thrombolytic therapy, as well as from patients 
receiving therapy through ongoing clinical trials.  In April 1995, the FDA 
approved for marketing an accelerated dosage of Activase.  In June 1996, the 
Company received clearance from the FDA to market Activase for the treatment 
of acute ischemic stroke or brain attack.  Activase is the first therapy to be 
indicated for the management of stroke. In addition, the Company is conducting 
Phase II clinical trials on a second generation of t-PA.

Genentech is aware of other companies actively pursuing the development for 
the U.S. market of nonrecombinant or recombinant t-PA or derivatives of that 
substance, and additional companies or combinations of companies pursuing the 
development of other types of potentially competitive thrombolytic agents.  In 
October 1996, Boehringer Mannheim (BM) announced that the FDA licensed its 
heart attack drug, reteplase (brand name Retevase, registered trademark).  The 
Company believes reteplase infringes on its patents and has filed a patent 
infringement action against BM.  

Protropin and Nutropin:  Lilly received FDA approval in 1987 to market 
its growth hormone product for treatment of growth hormone inadequacy in 
children.  Three other companies - BioTechnology General (BTG), Novo 
Nordisk A/S (Novo) and Pharmacia & Upjohn - received FDA approval in 1995 to 
market their growth hormone products for the treatment of growth hormone 
inadequacy in children, although BTG has been preliminarily enjoined 
from selling its product.  A fifth competitor, Serono Laboratories, Inc., 
received FDA approval in October 1996 to market its growth hormone product.  
Novo introduced its product in the U.S. market in February 1997 after the 
preliminary injunction against Novo was stayed. Pharmacia & Upjohn has 
marketed their product in the U.S. market since late 1995.  In December 
1995, Genentech received clearance from the FDA to market Nutropin 
AQ, the first and only liquid (aqueous) recombinant human growth hormone 
product available.  

Based on information currently available, Protropin and Nutropin have 
approximately a 66% share of the U.S. market for treatment of children with 
growth hormone inadequacy. 

Pulmozyme:  Sales of Pulmozyme for the management of CF in the U.S., Canada 
and some countries in Europe began in early 1994.  In December 1996, Pulmozyme 
was cleared for marketing by the FDA for the management of CF patients with 
advanced disease; a condition that affects approximately 500 patients in the 
U.S.  In accordance with the Agreement with Roche, in the fourth quarter of 
1995, HLR obtained exclusive rights to sell Pulmozyme outside of the U.S., and 
the Company receives a royalty on such sales.  

Actimmune:  Actimmune received designation as an Orphan Drug by the FDA in 
1990 for the treatment of CGD.


Forward-Looking Statements

The following section contains forward-looking statements that are based on 
the Company's current expectations.  Because the Company's actual results may 
differ materially from any forward-looking statements made by or on behalf of 
the Company, this section also includes a discussion of important factors that 
could affect the Company's actual future results, including its product sales, 
royalties, contract revenues, expenses and net income.

Total Product Sales:  Product sales will be dependent on the overall 
competitive environment.  Other factors affecting the Company's total product 
sales include, but are not limited to, the amount and timing of the Company's 
sales to HLR, the amount of sales to customers in the U.S., increased 
competition in the growth hormone and thrombolytic markets, the timing and 
amount of bulk shipments to licensees, and the possibility of the introduction 
of a new product in late 1997.

Activase Sales:  The Company faces new competition in the thrombolytic market. 
The Company is aware that one company received FDA approval in October 1996, 
to market its product for the treatment of AMI in the U.S.  The Company has 
brought suit against that company for patent infringement.  In addition, there 
is an increasing use of angioplasty in the treatment of AMI patients in lieu 
of the use of thrombolytic therapy.  Depending on the extent and type of new 
competition, the Company's total Activase sales could be materially affected.  
Other factors affecting the Company's Activase sales include, but are not 
limited to, the timing of FDA approval, if any, of additional competitive 
products, pricing decisions made by the Company, the outcome of litigation 
against Boehringer Mannheim GmbH and Boehringer Mannheim Corporation involving 
the Company's patents for tissue plasminogen activator and processes related 
to its production and formulation, the outcome of the GUSTO III clinical trial 
which involved a head-to-head comparison of Activase and Retevase and which 
failed to demonstrate that Retavase has a statistically significant lower 
mortality rate than Activase, the increasing use of other therapies such as 
angioplasty techniques for the treatment of AMI, and the impact of the FDA's 
recent clearance for the Company to market Activase for the treatment of acute 
ischemic stroke.  

Growth Hormone Sales:  The Company continues to face the possibility of 
increased competition in the growth hormone market.  Three companies received 
FDA approval in 1995, and a fourth company received FDA approval in October 
1996, to market their growth hormone products for treatment of growth hormone
inadequacy in children, although one of those companies has been preliminarily 
enjoined from selling its product.  Two of the Company's competitors have 
received approval to market their existing human growth hormone products for 
additional indications.  The Company expects such competition to have an 
adverse effect on its sales of Protropin, Nutropin and Nutropin AQ which, 
depending on the extent and type of competition, could be material.  Other 
factors affecting the Company's growth hormone sales include, but are not 
limited to, the timing of FDA approval, if any, of other new competitive 
products, the outcome of litigation involving the Company's patents for human 
growth hormone and related processes, pricing decisions made by the Company, 
the availability of third-party reimbursement for the cost of growth hormone 
therapy, and the impact of Nutropin as a treatment for short stature 
associated with Turner syndrome.

Pulmozyme Sales:  Factors that may influence the future sales of Pulmozyme 
include, but are not limited to, physician perception of the number and kinds 
of patients who will benefit from such therapy, the availability of third-
party reimbursement for the costs of therapy, the timing of the development of 
alternative therapies for the treatment and care of CF, whether and when 
additional indications are approved, and the cost of therapy.

Royalty and Contract Revenues:  Royalty and contract revenues in future 
periods could vary significantly from 1996 levels.  Major factors affecting 
these revenues include, but are not limited to:  HLR's decisions to exercise 
or not to exercise its option to develop and sell the Company's future 
products in non-U.S. markets and the timing and amount of related development 
cost reimbursement, if any; variations in HLR's sales of Genentech products, 
and other licensees' sales of licensed products; the expiration of royalties 
from Lilly in 1998; fluctuations in foreign currency exchange rates; the 
timing of non-U.S. approvals, if any, for products licensed to HLR; whether 
and when contract benchmarks are achieved; the initiation of other new 
contractual arrangements; and the conclusion of existing arrangements with 
other companies and HLR.

R&D Expenses:  The Company intends to continue its commitment to aggressive 
investment in R&D.  As it continues late-stage clinical testing of products, 
the Company anticipates that its R&D expenses will continue at a high 
percentage of revenues over the short-term.  Over the long-term, however, R&D 
as a percent of revenues should decrease, although in dollar terms R&D 
spending is generally expected to rise as revenues rise. Factors affecting the 
Company's R&D expenses include, but are not limited to: the outcome of 
clinical trials currently being conducted; the number of products entering 
into development from late-stage research; future levels of the Company's 
product sales (including the impact of competition), royalty and contract 
revenues; the possibility of competition with respect to products or 
technologies under development; and decisions by HLR to exercise or not to 
exercise its option to develop and sell potential products of the Company in 
non-U.S. markets and the timing of such decisions.

Income Tax Provision:  The Company expects that its effective tax rate will 
increase from the current rate of 20% to between 25% and 35% in 1997 and for 
the next several years, dependent upon several factors.  These factors 
include, but are not limited to, changes in tax laws and rates, future levels 
of R&D spending, the outcome of clinical trials of certain development 
products, the Company's success in commercializing such products, and 
potential competition regarding the products.

Successful Development of Products:  The Company intends to continue to 
develop new products. Successful pharmaceutical product development is highly 
uncertain and is dependent on numerous factors, many of which are beyond the
Company's control. Products that appear promising in the early phases of 
development may fail to reach the market for numerous reasons. They may be
found to be ineffective or to have harmful side effects in preclinical or 
clinical testing, may fail to receive necessary regulatory approvals, may turn 
out to be uneconomical because of manufacturing costs or other factors, or may 
be precluded from commercialization by the proprietary rights of others or by
competing products or technologies for the same indication.  Success in 
preclinical and early clinical trials does not ensure that large scale 
clinical trials will be successful. Clinical results are frequently 
susceptible to varying interpretations which may delay, limit or prevent 
regulatory approvals. The length of time necessary to complete clinical trials 
and to submit an application for marketing approval for a final decision by a 
regulatory authority varies significantly and may be difficult to predict.

Uncertainties Surrounding Proprietary Rights:  The patent positions of 
pharmaceutical and biotechnology companies can be highly uncertain and involve 
complex legal and factual questions. Accordingly, the breadth of claims 
allowed in such companies' patents cannot be predicted. Patent disputes are 
frequent and can preclude commercialization of products. The Company, as in 
the past, may be involved in future material patent litigation. Such 
litigation is costly in its own right and could subject the Company to 
significant liabilities to third parties and, if decided adversely, the 
Company may need to obtain third-party licenses or cease using the technology 
or product in dispute.  The presence of patents or other proprietary rights 
belonging to other parties may lead to the termination of R&D of a particular 
product. The Company believes it has strong patent protection or the potential 
for strong patent protection for a number of its products that generate sales 
and royalty revenue or that the Company is developing; however, the courts 
will determine the ultimate strength of patent protection of the Company's 
products and those on which the Company earns royalties.

Liquidity:  The Company believes that its cash, cash equivalents, and short-
term investments, together with funds provided by operations and leasing 
arrangements, will be sufficient to meet its foreseeable operating cash 
requirements.  In addition, the Company believes it could access additional 
funds from the capital markets.  Factors affecting the Company's cash position 
include, but are not limited to, future levels of the Company's product sales, 
royalty and contract revenues, expenses and capital expenditures.

Market Potential/Risk:  Over the longer term, the Company's (and its 
partners') ability to successfully market current products, expand their 
usage, and bring new products to the marketplace will depend on many factors, 
including, but not limited to, the effectiveness and safety of the products, 
FDA and foreign regulatory agencies' approvals for new products and new 
indications, and the degree of patent protection afforded to particular 
products.

Roche Holdings, Inc.:  The Company expects to continue to have material 
transactions with Roche, including royalty and contract development revenues, 
product sales and joint product development.

Foreign Exchange:  The Company receives royalty revenues from countries 
throughout the world.  As a result, the Company's financial results could be 
significantly affected by factors such as changes in foreign currency exchange 
rates or weak economic conditions in the foreign markets in which the 
Company's products are sold.  The Company is exposed to changes in exchange 
rates in Europe, Asia and Canada.  When the U.S. dollar strengthens against 
the currencies in these countries, the U.S. dollar value of non-U.S. dollar-
based revenue decreases; when the U.S. dollar weakens, the U.S. dollar value 
of the non-U.S. dollar-based revenues increases.  Accordingly, changes in 
exchange rates, and in particular a strengthening of the U.S. dollar, may 
adversely affect the Company's royalty revenues as expressed in U.S. dollars.

To mitigate this risk, the Company hedges certain of these anticipated 
revenues by purchasing options with expiration dates and amounts of currency 
that are based on a portion of probable revenues so that the adverse impact of 
movements in currency exchange rates on the non-dollar denominated revenues 
will be at least partly offset by an associated increase in the value of the 
option.  The Company also enters into forward contracts to lock in the dollar 
value of a portion of these anticipated revenues.

Interest Rates:  The Company's interest income is sensitive to changes in the 
general level of U.S. interest rates.  In this regard, changes in U.S. 
interest rates affect the interest earned on the Company's cash equivalents, 
short-term investments and long-term investments.  To mitigate the impact of 
fluctuations in U.S. interest rates, the Company enters into interest rate 
swap transactions which generally involve the receipt of fixed rate interest 
and the payment of floating rate interest without the exchange of the 
underlying principal.  These agreements have the effect of locking in rates 
for longer periods of time than the duration of short-term investments.

Equity Securities:  As part of its strategic alliance efforts, the Company 
invests in equity instruments that are subject to fluctuations from market 
value changes in stock prices.  To mitigate this risk, certain equity 
securities are hedged with costless collars.  A costless collar is a purchased 
put option and a written call option in which the cost of the purchased put 
and the proceeds of the written call offset each other; therefore, there is no 
initial cost or cash outflow for these instruments at the time of purchase.  
The purchased put protects the Company from a decline in the market value of 
the security below a certain minimum level (the put "strike" level); while the 
call effectively limits the Company's potential to benefit from an increase in 
the market value of the security above a certain maximum level (the call 
"strike" level).

Credit Risk of Counterparties:  The Company could be exposed to losses related 
to the above financial instruments should one of its counterparties default.  
This risk is mitigated through credit monitoring procedures.

Legal Proceedings:  The Company is a party to various legal proceedings 
including patent infringement cases and various cases involving product 
liability and other matters. See Item 3 "Legal Proceedings" below for further 
information.

Government Regulation

The pharmaceutical industry is subject to stringent regulation with respect to 
product safety and efficacy by various federal, state and local authorities.  
Of particular significance are the FDA's requirements covering research and 
development, testing, manufacturing, quality control, labeling and promotion 
of drugs for human use. A pharmaceutical product cannot be marketed in the 
U.S. until it has been approved by the FDA, and then can only be marketed for 
the indications and claims approved by the FDA.  As a result of these 
requirements, the length of time, the level of expenditures and the laboratory 
and clinical information required for approval of an NDA (New Drug 
Application), a PLA (Product License Application), a BLA (Biologics License 
Application) or an ELA (Establishment License Application) are substantial and 
can require a number of years, although recently revised regulations are 
designed to reduce somewhat the time for approval of new products.

Although it is difficult to predict the ultimate effect, if any, these matters 
or any other pending or future legislation, regulations or government actions 
may have on its business, the Company believes that the development of new and 
improved products which address unmet medical needs should enable it to 
compete effectively within this environment.

Research and Development

A major portion of the Company's operating expenses to date have been related 
to the R&D of products either on its own behalf or under contracts.  During 
1996, 1995 and 1994 the Company's research and development expenses were 
$471.1 million, $363.0 million and $314.3 million, respectively.  The Company 
has sponsored approximately 92%, 95% and 98% of its research and development 
for the years 1996, 1995 and 1994, respectively.

The Company's research efforts have been the primary source of the Company's 
products.  The Company intends to maintain its strong commitment to research 
as an essential component of its product development effort.  In the future, 
licensed technology developed by outside parties could become an additional 
source of potential products.

Human Resources

As of December 31, 1996, the Company had 3,071 employees in the United States.

Environment

The Company seeks to comply with all applicable statutory and administrative 
requirements concerning environmental quality.  The Company has made, and will 
continue to make, the necessary expenditures for environmental compliance and 
protection.  Expenditures for compliance with environmental laws have not had 
and are not expected to have a material effect on the Company's capital 
expenditures, earnings or competitive position.


ITEM 2.   PROPERTIES

The Company's major facilities are located in a research and industrial park 
in South San Francisco, California in both leased and owned properties.  The 
Company currently occupies twenty-two buildings for its R&D, manufacturing, 
marketing and administrative activities.  Fourteen of the buildings are owned 
property and eight are leased.  The Company has made and continues to make 
improvements to these properties to accommodate its growth.  In addition, the 
Company owns approximately 17 acres adjacent to its current facilities that 
may be used for future expansion.  In 1995, the Company began development of a 
new manufacturing facility of approximately 0.4 million square feet in 
Vacaville, California under an operating lease arrangement.  Completion of the 
project is expected in 1998.  The Company also has leases for certain 
additional office facilities in several locations in the United States.

The Company believes its facilities are in good operating condition and that 
the real property owned or leased, combined with the new Vacaville site, are 
adequate for all present and foreseeable future uses.  The Company believes 
any additional facilities could be obtained or constructed with the Company's 
capital resources.


ITEM 3.   LEGAL PROCEEDINGS

The Company is a party to various legal proceedings including patent 
infringement cases involving human growth hormone products and Activase; 
product liability cases; and employment related cases.  

In late 1995, the Company received and responded to grand jury document 
subpoenas from the United States District Court for the Northern District of 
California for documents relating to the Company's clinical, sales, and 
marketing activities associated with human growth hormone.  In February 1997, 
the Company received another grand jury document subpoena from the same court 
relating to that subject matter.

On June 28, 1995 and August 10, 1995, the U.S. District Court for the Southern 
District of New York issued preliminary injunctions against Novo and certain 
of its affiliates and BTG and its affiliate, respectively, which prohibit each 
of them, pending the Court's final determination of the action, from 
importing, making, using and selling their human growth hormone products in 
the United States.  Each of Novo and BTG appealed the Court's decision.  On 
February 26, 1996, the U.S. Court of Appeals for the Federal Circuit 
overturned the preliminary injunction against Novo, and in April 1996, the 
Court of Appeals affirmed the preliminary injunction against BTG. BTG's 
subsequent petition to the U.S. Supreme Court for review of that decision was 
denied.  In June 1996, the U.S. District Court for the Southern District of 
New York issued a second preliminary injunction against Novo to prohibit it, 
pending the Court's final determination of the action, from importing, making, 
using, and selling its human growth hormone product in the U.S.  Novo appealed 
that decision, and in December 1996, the Court of Appeals for the Federal 
Circuit stayed the second preliminary injunction against Novo pending further 
proceedings.  In March 1997, the Court of Appeals invalidated the patent that 
was the subject of the preliminary injunction.  Future court decisions will 
determine whether Novo's and BTG's products will be permanently enjoined from 
the U.S. market.

On August 19, 1994 and August 30, 1994, two class action suits were filed in 
the U.S. District Court for the District of Minnesota against the Company, one 
of its executives, Caremark International, Inc. (Caremark), certain of its 
executives and Dr. David R. Brown alleging, in general, causes of action under 
the Racketeer Influenced and Corrupt Organizations Act and various state 
statutory and common law theories.  In addition, the suits alleged that the 
defendants made improper payments to Dr. Brown in connection with Dr. Brown's 
prescription of Protropin for the plaintiffs rather than a competing product, 
and that the plaintiffs were injured by purchasing Protropin at costs 
approximately 30% higher than a competing product.  These suits were 
voluntarily dismissed without prejudice in November 1996.  A suit was filed in 
the District Court of Hennepin County, Minnesota in July 1996, against the 
Company, Dr. Brown and Caremark, alleging the defendants paid kickbacks to Dr. 
Brown with an agreement that Dr. Brown would prescribe Protropin to his 
patients rather than a competing product.  The plaintiffs seek disgorgement of 
profits and allege causes of action under various state statutory and common 
law theories, including fraud and breach of fiduciary duty.  A similar suit 
was filed in the U.S. District Court for the District of South Dakota, 
Southern Division, on July 13, 1995 against the Company, Caremark and Dr. 
Brown, alleging the same causes of action as above, as well as intentional 
infliction of emotional distress but not state and common law claims.  

Based upon the nature of the claims made and the investigations completed to 
date by the Company and its counsel, the Company believes the outcome of the 
above actions will not have a material adverse effect on the financial 
position, results of operations or cash flows of the Company.  However, were 
an unfavorable ruling to occur in any quarterly period, there exists the 
possibility of a material impact on the net income of that period.


ITEM 4.   SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

Not applicable.

<TABLE>
<CAPTION>
                             GENENTECH, INC.

                            EXECUTIVE OFFICERS

The executive officers of the Company and their respective ages and positions 
with the Company are as follows: 
<S>                             <C> <C>
Name                             Age Position

Arthur D. Levinson, Ph.D.        46  President and Chief Executive Officer
William D. Young                 52  Chief Operating Officer 
Louis J. Lavigne, Jr.            48  Executive Vice President and Chief Financial
                                      Officer
John P. McLaughlin               45  Executive Vice President and Secretary
Judy Heyboer                     47  Senior Vice President, Human Resources
David C. Roche                   47  Senior Vice President, Sales and
                                      Marketing
Robert Arathoon, Ph.D.           44  Vice President - Process Sciences
Gregory Baird                    46  Vice President - Corporate Communications
Joffre Baker, Ph.D.              49  Vice President - Research Discovery
David W. Beier                   48  Vice President - Government Affairs
Robert Garnick, Ph.D.            47  Vice President - Quality
Marty Glick                      47  Vice President - Finance - Tax and
                                      Treasury
Bradford S. Goodwin              42  Vice President - Finance and Controller
Susan D. Hellmann, M.D., M.P.H.  39  Vice President - Medical Affairs and 
                                     Chief Medical Officer
Dennis J. Henner, Ph.D.          45  Vice President - Research
Paul F. Hohenschuh               53  Vice President - Manufacturing
Paula Jardieu, Ph.D.             46  Vice President - Pharmacological Sciences
Edmon R. Jennings                49  Vice President - Corporate Development
Stephen G. Juelsgaard            48  Vice President, General Counsel and
                                      Assistant Secretary
Cynthia J. Ladd                  41  Vice President - Corporate Law
Ted W. Love, M.D.                37  Vice President - Product Development
M. David MacFarlane, Ph.D.       56  Vice President - Regulatory Affairs
Polly Moore, Ph.D.               49  Vice President - Information Resources
James P. Panek                   43  Vice President - Engineering and
                                      Facilities
Kim Popovits                     38  Vice President - Sales
Nicholas J. Simon                42  Vice President - Business and Corporate
                                      Development
Daniel K. Spiegelman             38  Treasurer  
David Stump, M.D.                47  Vice President - Clinical Research and
                                      Genentech Fellow
</TABLE>
All officers are elected annually by the Board of Directors.  There is no 
family relationship among any of the officers or directors.

Business Experience

Dr. Levinson was appointed President and Chief Executive Officer in July 1995. 
He was elected Senior Vice President in December 1992.  Dr. Levinson has held 
a number of other positions, including Vice President of Research, subsequent 
to joining the Company in May 1980 as a Senior Scientist.

Mr. Young was appointed Chief Operating Officer in March 1997.  He served as 
Executive Vice President from January 1996 to March 1997, as Senior Vice 
President of the Company from September 1988 to January 1996 and as Vice 
President of Manufacturing and Process Sciences from April 1983 until 
September 1988.  Mr. Young joined the Company in September 1980 as Director of 
Manufacturing from Eli Lilly and Company.


Mr. Lavigne was appointed Executive Vice President in March 1997.  He served 
as Senior Vice President from July 1994 to March 1997.  He was appointed Chief 
Financial Officer in August 1988 and had been Vice President since July 1986.  
Mr. Lavigne joined the Company in July 1982 from Pennwalt Corporation and 
became Controller in May 1983 and an officer of the Company in February 1984.

Mr. McLaughlin was appointed Executive Vice President in December 1995. Since 
July 1994, he had served as Senior Vice President and Secretary.  Mr. 
McLaughlin was appointed Senior Vice President, General Counsel and Secretary 
in June 1993 and served as Vice President, General Counsel and Secretary since 
February 1989. He joined the Company as Vice President of Government Affairs 
in September 1987 from Royer, Shacknai & Mehle, a Washington, D.C. law firm, 
where he was a partner.  Mr. McLaughlin was Counsel to the House Energy and 
Commerce Subcommittee on Health and the Environment and earlier served as 
Counsel to the House Subcommittee on Consumer Protection and Finance.

Ms. Heyboer joined the Company as Senior Vice President of Human Resources in 
August 1996.  Prior to joining Genentech, she was employed at Acuson 
Corporation from 1983 to 1996, most recently as a Senior Vice President, 
Employee Relations.

Mr. Roche joined Genentech in July 1996 as Senior Vice President of Sales and 
Marketing.  Prior to joining the Company, Mr. Roche was Vice President of 
Sales and Marketing at Janssen Pharmaceutica USA since 1994, and before that 
was President of the Prescription Products Division at Marion Merrell Dow USA.

Dr. Arathoon was appointed Vice President of Process Sciences in April 1996.  
Since joining the Company in 1983 from Wellcome Foundation, Dr. Arathoon has 
held a series of positions of increasing responsibility, most recently Senior 
Director of Process Sciences from November 1994 to April 1996.

Mr. Baird joined the Company in February 1992 as Vice President of Corporate 
Communications.  Prior to joining Genentech, Mr. Baird was employed by G.D. 
Searle & Co. for five years as Vice President of Corporate Communications 
(Searle is a wholly-owned subsidiary of Monsanto Company).

Dr. Baker was appointed Vice President, Research Discovery in February 1997.  
He had served as Senior Director, Research Discovery since March 1993 and 
prior to that as Director, Cardiovascular Research from 1990 to 1993.  Prior 
to joining the Company in 1988 as a Senior Scientist, Dr. Baker was an 
associate professor at the University of Kansas.

Mr. Beier joined the Company in March 1989 as Vice President of Government 
Affairs.  Prior to joining Genentech, Mr. Beier spent 10 years as Counsel to 
the Committee on the Judiciary of the United States House of Representatives 
where he was responsible for intellectual property and international trade 
issues.

Dr. Garnick was elected Vice President of Quality in April 1994.  He was 
Senior Director of Quality Control from 1990 to 1994 and Director of Quality 
Control from 1988 to 1990.  Dr. Garnick joined the Company in August 1984 from 
Armour Pharmaceutical.  

Mr. Glick was appointed Vice President of Finance - Tax and Treasury in 
December 1996.  He has been a Vice President of the Company since July 1991 
and was Treasurer from July 1990 to December 1996.  He joined the Company in 
June 1987 as Director of Tax.  Before joining Genentech, Mr. Glick was 
employed by Levi Strauss & Co. for seven years, most recently as Director of 
Tax Planning.

Mr. Goodwin was appointed Vice President of Finance in December 1996.  He has 
been a Vice President of the Company since July 1993 and has served as 
Controller since June 1989.  Previously he was the Director of Financial 
Planning and Analysis, the Assistant Controller and the General Auditor.  He 
joined Genentech in April 1987.

Dr. Hellmann was appointed Vice President of Medical Affairs in March 1996 and 
Chief Medical Officer in December 1996.  Prior to joining the Company as 
Clinical Scientist in 1995, Dr. Hellmann was Associate Director of Clinical 
Cancer Research at Bristol-Myers Squibb Pharmaceutical Research Institute from 
1993 to 1995, and from 1992 to 1993 was a medical oncologist with Lexington 
Oncology Associates.

Dr. Henner was promoted to Vice President of Research in April 1996.  He had 
served as Vice President of Research Technology since July 1994, and as Senior 
Director of Research Technology from 1990 to 1994.  Dr. Henner joined the 
Company in 1981 as a Scientist in Research.  Prior to joining Genentech, Dr. 
Henner was at Scripps Clinic and Research Foundation.

Mr. Hohenschuh was elected Vice President of Manufacturing in September 1989.  
He was Vice President of Biochemical Manufacturing from July 1986 until 
September 1989 and Senior Director of Biochemical Manufacturing from June 1985 
to June 1986.  Mr. Hohenschuh joined the Company in October 1982 as Director 
of Biochemical Manufacturing.

Dr. Jardieu was appointed Vice President, Pharmacological Sciences in February 
1997.  She joined the Company in 1986 as a Scientist and subsequently held the 
positions of Senior Scientist, Staff Scientist and Senior Director of 
Pharmacological Sciences.  Prior to joining the Company, Dr. Jardieu was at 
John Hopkins University School of Medicine where she held a faculty position.

Mr. Jennings was appointed Vice President of Corporate Development in December 
1995.  He served as Vice President of Sales and Marketing from January 1994 to 
December 1995, and had served as Vice President of Sales since January 1991.  
He joined the Company in September 1985 as Western Area Sales Manager.  Prior 
to joining Genentech, Mr. Jennings was Western Region Sales Manager of 
Bristol-Myers' Oncology Division.  Mr. Jennings held various sales and 
management positions during his twelve-year career with Bristol-Myers.

Mr. Juelsgaard was appointed Vice President, General Counsel and Assistant 
Secretary in July 1994.  He was appointed Vice President of Corporate Law in 
February 1993.  He joined the Company in 1985 as Corporate Counsel and 
subsequently held the positions of Senior Corporate Counsel and Chief 
Corporate Counsel.

Ms. Ladd was appointed Vice President of Corporate Law in February 1996.  She 
joined the Company in 1989 as Corporate Counsel and subsequently held the 
positions of Senior Corporate Counsel and Chief Corporate Counsel.

Dr. Love was appointed Vice President of Product Development in March 1996.  
He was Senior Director of Product Development since 1995, and Clinical 
Scientist from 1993 to 1995.  Prior to joining the Company in 1992 as a 
Research Physician, Dr. Love was a member of the Cardiology Division at 
Massachusetts General Hospital, Harvard Medical School.

Dr. MacFarlane joined the Company in August 1989 as Vice President of 
Regulatory Affairs.  Dr. MacFarlane was employed by Glaxo, Inc. from 1978 
until he joined Genentech.  At Glaxo, Dr. MacFarlane had served as Vice 
President of Regulatory Affairs, Director of Regulatory Affairs, and Director 
of Research and Professional Services.

Dr. Moore was appointed Vice President of Information Resources in April 1994. 
She was Senior Director of Information Resources from July 1992 to April 1994 
and Director of Computer Resources from November 1987 to June 1992.  Dr. Moore 
joined Genentech in August 1982 as a Senior Systems Analyst in Scientific 
Computing.

Mr. Panek was appointed Vice President of Engineering and Facilities in July 
1993.  He joined the Company in 1982 and held a number of positions in the 
manufacturing division before becoming Director of Engineering and Facilities 
in 1988 and Senior Director of Engineering and Facilities in July 1991.  Prior 
to joining Genentech, Mr. Panek was employed by Eli Lilly and Company for six 
years.

Ms. Popovits was elected Vice President of Sales in October 1994.  She was 
Director of Field Sales from January 1993 to 1994 and Regional Manager of the 
Northeast Region from October 1989 to January 1993.  Ms. Popovits was at 
American Critical Care, a division of American Hospital Supply Corporation, 
for six years prior to joining the Company in November 1987 as Division 
Manager in the Southeast region. 

Mr. Simon was appointed Vice President of Business and Corporate Development 
in December 1995.  He has been Vice President of Business Development since 
December 1994.  He was Senior Director of Business Development from December 
1993 to 1994.  Mr. Simon joined Genentech as a Director in Business 
Development in December 1989 from Xoma Corporation.

Mr. Spiegelman was appointed Treasurer in December 1996.  He joined the 
Company in July 1991 as Treasury Manager and subsequently held the position of 
Assistant Treasurer from July 1992 to December 1996.

Dr. Stump was named a Genentech Fellow in January 1996 in addition to his 
responsibilities as Vice President of Clinical Research, a position he has 
held since July 1995.  He was Senior Director of Clinical Research from 1991 
to 1995, and joined the Company as Director of Clinical Research in 1989.  
Prior to joining Genentech, Dr. Stump was an Associate Professor of Medicine 
and Biochemistry at the University of Vermont.




































                                 PART II

ITEM 5.   MARKET FOR THE REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER
           MATTERS

Not applicable.

ITEM 6.   SELECTED FINANCIAL DATA

The section labeled "11-Year Financial Summary" appearing on pages 76 and 77 
of the Company's 1996 Annual Report to Stockholders is incorporated herein by 
reference.

ITEM 7.   MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
           AND RESULTS OF OPERATION

The section labeled "Financial Review" appearing on pages 41 through 49 of the 
Company's 1996 Annual Report to Stockholders is incorporated herein by 
reference.

ITEM 8.   CONSOLIDATED FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The Consolidated Financial Statements and Notes to Consolidated Financial 
Statements appearing on pages 51 through 74, the Report of Ernst & Young LLP, 
Independent Auditors, appearing on page 75 and the section entitled "Quarterly 
Financial Data (unaudited)" appearing on page 75 of the Company's 1996 Annual 
Report to Stockholders are incorporated herein by reference.

ITEM 9.   CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
           FINANCIAL DISCLOSURE

Not applicable.

































                                     PART III

ITEM 10.   DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

(a) The sections labeled "Nominees" and "Section 16 (a) Beneficial Ownership 
Reporting Compliance" appearing on pages 4 through 7 and 12 of the Company's 
Proxy Statement in connection with the 1997 Annual Meeting of Stockholders are 
incorporated herein by reference.

(b) Information concerning the Company's Executive Officers is set forth in 
Part I of the Form 10-K.

ITEM 11.   EXECUTIVE COMPENSATION

The sections labeled "Executive Compensation", "Compensation of Directors", 
"Compensation of Executive Officers", "Summary of Compensation", "Stock Option 
Grants and Exercises", "Loans and Other Compensation" and "Compensation 
Committee Interlocks and Insider Participation" appearing on pages 12 through 
17 and 20 of the Company's Proxy Statement in connection with the 1997 Annual 
Meeting of Stockholders are incorporated herein by reference.

ITEM 12.   SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT 

The sections labeled "Merger with Roche Holdings, Inc.", "Security Ownership 
of Certain Beneficial Owners" and "Security Ownership of Management" appearing 
on pages 1 through 3 and 11 through 12 of the Company's Proxy Statement in 
connection with the 1997 Annual Meeting of Stockholders are incorporated 
herein by reference.

ITEM 13.   CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS 

The section labeled "Certain Relationships and Related Transactions" appearing 
on pages 20 through 22 of the Company's Proxy Statement in connection with the 
1997 Annual Meeting of Stockholders is incorporated herein by reference.































                                     PART IV

ITEM 14.   EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K

(a) 1. Index to Financial Statements

The following Financial Statements and supplementary data are included in
the Company's 1996 Annual Report to Stockholders and are incorporated herein 
by reference pursuant to Item 8 of this Form 10-K.


                                                             Page(s) in
                                                             1996 Annual
                                                        Report to Stockholders
                                                        ----------------------
  Consolidated Statements of Income for each 
   of the three years in the period ended 
   December 31, 1996                                              [51]      

  Consolidated Statements of Cash Flows for each 
   of the three years in the period ended 
   December 31, 1996                                              [52]

  Consolidated Balance Sheets at December 31, 
   1996 and 1995                                                  [53]

  Consolidated Statements of Stockholders' Equity 
   for each of the three years in the period ended 
   December 31, 1996                                              [54]

  Notes to Consolidated Financial Statements                     [55-74]

  Report of Ernst & Young LLP, Independent Auditors               [75]

  Quarterly Financial Data (unaudited)                            [75]


2. Financial Statement Schedule

The following schedule is filed as part of this Form 10-K:

Schedule II- Valuation and Qualifying Accounts for each of the three years in 
the period ended December 31, 1996.






















All other schedules are omitted because they are not applicable, or not 
required, or because the required information is included in the
consolidated financial statements or notes thereto.


3. Exhibits 

   Exhibit No.                          Description
   -----------                          -----------

   3.1    Certificate of Incorporation.(1)

   3.2    Amended Certificate of Incorporation.(5)

   3.3    Restated By-Laws.(3)

   4.1    Indenture, dated March 27, 1987 ("Indenture") for U.S. $150,000,000
           5% Convertible Subordinated Debentures due 2002.(2)

   4.2    First Supplemental to Indenture, dated August 17, 1990.(3)

   4.3    Second Supplemental to Indenture, dated October 18, 1995. (7)

  10.1    Patent License Agreement with Columbia University dated October 12,
           1988.(2)

  10.2    Amended and Restated Contract for the Sale and Distribution of
           Protropin dated as of March 1, 1991.(4)

  10.3    Agreement and Plan of Merger, dated as of May 23, 1995, as amended
           and restated, among the Company, Roche Holdings, Inc. and HLR
          (U.S.) II, Inc. with exhibits.(5)

  10.4    Amended Governance Agreement, dated September 7, 1990, between the
           Company and Roche Holdings, Inc.(5)
  
  10.5    Heads of Agreement, dated as of February 11, 1992, between the 
           Company and F. Hoffmann-LaRoche Ltd.(4)

  10.6    Agreement dated June 6, 1991 between the Company and Grandview 
           Drive Joint Venture.(4)

  10.7    Agreement dated March 17, 1992 between the Company and Robert A. 
           Swanson.(4)

  10.8    Agreement between Genentech and F. Hoffman-La Roche Ltd 
           regarding commercialization of Genentech's products outside the
           United States dated as of October 25, 1995.(5)

  10.9    Guaranty Agreement between Genentech and Roche Holding, Ltd dated
           as of October 25, 1995.(5)

  10.10   Amended and Restated Lease Agreement, dated December 8, 1995,
           between the Company and BNP Leasing Corporation.(7)

  10.11   Amended and Restated Purchase Agreement, dated December 8, 1995,
           between the Company and BNP Leasing Corporation.(7)

  10.12   Guiding Principles for the Genentech/Roche Relationship.(8)

  13.1    1996 Annual Report to Stockholders.(8)

  23.1    Consent of Ernst & Young LLP, Independent Auditors.(8)

  27.1    Financial Data Schedule.(8)

  28.1    Description of the Company's capital stock.(1)

  99.1*   1984 Incentive Stock Option Plan, as amended and restated as of
           October 16, 1996.(8)

  99.2*   1984 Non-Qualified Stock Option Plan, as amended and restated
           as of October 16, 1996.(8)

  99.3*   Restated Relocation Loan Program.(4)

  99.4*   Restated 401(k) Plan.(7)

  99.5*   1991 Employee Stock Plan, as amended and restated as of October
           25, 1995.(6)

  99.6*   1990 Stock Option/Stock Incentive Plan, as amended and restated
           as of October 16, 1996.(8)

  99.7*   Supplemental Plan.(4)

  99.8*   1994 Stock Option Plan, as amended and restated as of October 16,
           1996.(8)

  99.9*   1996 Stock Option/Stock Incentive Plan, as amended and restated 
           as of October 16, 1996.(8)

  99.10*  Deferred Compensation Plan.(8)


* As required by Item 14(a)(3) of Form 10-K, the Company identifies this 
Exhibit as a management contract or compensatory plan or arrangement of the 
Company.
- --------------------
(1)   Filed as an exhibit to Annual Report on Form 10-K for the year ended
      December 31, 1986 and incorporated herein by reference.
(2)   Filed as an exhibit to Annual Report on Form 10-K for the year ended
      December 31, 1987 and incorporated herein by reference.
(3)   Filed as an exhibit to Annual Report on Form 10-K for the year ended
      December 31, 1990 and incorporated herein by reference.
(4)   Filed as an exhibit to Annual Report on Form 10-K for the year ended
      December 31, 1991 and incorporated herein by reference.
(5)   Filed as an exhibit to Form S-4 dated October 25, 1995 (registration
      statement no. 33-59949) and incorporated herein by reference.
(6)   Filed as an exhibit to Form S-8 dated October 25, 1995 (registration
      statement no. 33-59949-01) and incorporated herein by reference.
(7)   Filed as an exhibit to Annual Report on Form 10-K for the year 
      ended December 31, 1995 and incorporated herein by reference. 
(8)   Filed with this document.

(b) Reports on Form 8-K
    There were no reports on Form 8-K filed for the quarter ended December 31,
     1996.

























































                                   SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange 
Act of 1934, the registrant has duly caused this report to be signed on its 
behalf by the undersigned, thereunto duly authorized.


                                        GENENTECH, INC.
                                        Registrant
Date:  March 26, 1997
                                        By:  /S/BRADFORD S. GOODWIN
                                            ----------------------------------
                                             Bradford S. Goodwin
                                             Vice President - Finance and
                                              Controller
                                             (Principal Accounting Officer)


                                POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears 
below constitutes and appoints Louis J. Lavigne, Jr., Executive Vice President 
and Chief Financial Officer, and Bradford S. Goodwin, Vice President and 
Controller, his attorney-in-fact, with the full power of substitution, for him 
in any and all capacities, to sign any amendments to this report, and to file 
the same, with exhibits thereto and other documents in connection therewith, 
with the Securities and Exchange Commission, hereby ratifying and confirming 
all that said attorney-in-fact, or his substitute or substitutes, may do or 
cause to be done by virtue hereof.


Pursuant to the requirements of the Securities Exchange Act of 1934, this 
report has been signed below by the following persons on behalf of the 
registrant and in the capacities and on the dates indicated:


     Signature                    Title                         Date
     ---------                    -----                         ----


Principal Executive Officer:

  /S/ARTHUR D. LEVINSON           President, Chief Executive    March 26, 1997
- ---------------------------       Officer and Director
     Arthur D. Levinson


Principal Financial Officer:

  /S/LOUIS J. LAVIGNE, JR.        Executive Vice President      March 26, 1997
- ---------------------------       and Chief Financial Officer
     Louis J. Lavigne, Jr.        












Director:

  /S/HERBERT W. BOYER             Director                      March 26, 1997
- ---------------------------
     Herbert W. Boyer

  /S/JURGEN DREWS                 Director                      March 26, 1997
- ---------------------------
     Jurgen Drews

  /S/FRANZ B. HUMER               Director                      March 26, 1997
- ---------------------------
     Franz B. Humer

  /S/LINDA F. LEVINSON            Director                      March 26, 1997
- ---------------------------
     Linda F. Levinson

  /S/J. RICHARD MUNRO             Director                      March 26, 1997
- ---------------------------
     J. Richard Munro

  /S/DONALD L. MURFIN             Director                      March 26, 1997
- ---------------------------
     Donald L. Murfin

  /S/JOHN T. POTTS, JR.           Director                      March 26, 1997
- ---------------------------
     John T. Potts, Jr.

  /S/C. THOMAS SMITH, JR.         Director                      March 26, 1997
- ---------------------------
     C. Thomas Smith, Jr.

  /S/DAVID S. TAPPAN, JR.         Director                      March 26, 1997
- ---------------------------
     David S. Tappan, Jr.




















<TABLE>                 
                                                                              SCHEDULE II
                                       GENENTECH, INC.
                              VALUATION AND QUALIFYING ACCOUNTS
                        Years Ended December 31, 1996, 1995 and 1994
                                       (in thousands)
<CAPTION>
                                                     Additions
                                     Balance at     Charged to                  Balance at
                                    Beginning of     Costs and                    End of
                                       Period        Expenses    Deductions(1)    Period
                                     ----------     ----------    ----------    ----------
Allowance for doubtful accounts 
 and returns:
<S>                                 <C>            <C>           <C>           <C>

  Year Ended December 31, 1996:      $   6,672      $   9,887     $  (8,690)    $   7,869
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1995:      $   4,422      $  10,972     $  (8,722)    $   6,672
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1994:      $   3,572      $   5,583     $  (4,733)    $   4,422
                                     ==========     ==========    ==========    ==========

Inventory reserves:

  Year Ended December 31, 1996:      $   6,909      $   4,950     $  (2,580)    $   9,279
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1995:      $  13,008      $   3,690     $  (9,789)    $   6,909 
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1994:      $   2,606      $  11,940     $  (1,538)    $  13,008
                                     ==========     ==========    ==========    ==========

Reserve for non-marketable 
 equity securities:

  Year Ended December 31, 1996:      $   5,092      $       -     $    (102)    $   4,990
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1995:      $   4,623      $     469     $       -     $   5,092
                                     ==========     ==========    ==========    ==========
  Year Ended December 31, 1994:      $   3,875      $     748     $       -     $   4,623
                                     ==========     ==========    ==========    ==========

<FN>
(1)  Represents amounts written off or returned against the allowance or reserves.
</TABLE>
























<TABLE>


                     INDEX OF EXHIBITS FILED WITH FORM 10-K
                      FOR THE YEAR ENDED DECEMBER 31, 1996
<CAPTION>

                                                                   
Exhibit No.                      Description                      
- -----------                      -----------                      
  <S>         <C>

    
   10.12       Guiding Principles for the Genentech/Roche Relationship

   13.1        1996 Annual Report to Stockholders

   23.1        Consent of Ernst & Young LLP, Independent Auditors

   27.1        Financial Data Schedule

   99.1        1984 Incentive Stock Option Plan, as amended and restated as of 
                October 16, 1996

   99.2        1984 Non-Qualified Stock Option Plan, as amended and restated
                as of October 16, 1996

   99.6        1990 Stock Option/Stock Incentive Plan, as amended and restated
                as of October 16, 1996

   99.8        1994 Stock Option Plan, as amended and restated as of October
                16, 1996

   99.9        1996 Stock Option/Stock Incentive Plan, as amended and restated
                as of October 16, 1996

   99.10       Deferred Compensation Plan

</TABLE>




1







Genentech, Inc.
460 Point San Bruno Blvd.
South San Francisco, CA  94080
USA




Basel, February 19, 1997
PRIVILEGED AND CONFIDENTIAL




Gentlemen,

  In connection with the issuance of the attached "Guiding Principles" 
by F. Hoffmann-La Roche Ltd ("Roche") and Genentech, Inc. ("Genentech"), 
and in order to avoid any misunderstanding, we are writing to confirm 
that Roche views the "Guiding Principles" as a statement of the 
expectations of Roche and Genentech.  Neither Roche nor Genentech 
intends the "Guiding Principles" to be a binding agreement and neither 
Roche nor Genentech, by agreeing to issue the "Guiding Principles", 
makes any promises, express or implied, with respect to the matters 
addressed therein.  Nothing in the "Guiding Principles" will change or 
alter any of the existing agreements between Genentech and Roche.


                                    F.HOFFMANN-LA ROCHE LTD


                                           \S\DR. FRANZ B. HUMER
                                           ------------------------
                                    BY:     Dr. Franz B. Humer
                                    TITLE:  Chief Operating Officer


AGREED AND ACCEPTED:
GENENTECH, INC.


          \S\ARTHUR D. LEVINSON
          -------------------------
BY:       Arthur D. Levinson, Ph.D.
TITLE:    President and CEO



















                     GUIDING PRINCIPLES FOR THE
                    GENENTECH/ROCHE RELATIONSHIP


Corporate Governance

Genentech will continue to be governed by a Board of Directors as 
provided in the current Governance Agreement.

The Genentech Board of Directors (or its designated committee) will 
approve Genentech's budget, headcount, long range plan, capital 
expenditures, compensation programs and key business decisions in 
accordance with its fiduciary duties to its shareholders.  The members 
of the Board will determine the chairmanship of the Board and its 
committees as well as the composition of its committees.

The Genentech CEO will report to the Board.  All officers will continue 
with their current reporting relationships unless changed by the 
Genentech CEO or the Board.  The Executive Committee, Product 
Development Committee, Organization Development Committee and Research 
Review Committee (or their successors as established by the Genentech 
CEO or Board) will continue in their roles with respect to operations, 
product development and research at Genentech unless changed by the 
Genentech CEO or the Board.


Corporate Name

The name of Genentech will continue.  It is widely recognized within the 
scientific community and stands for excellence in innovation and there 
is therefore no reason to expect the important value and positioning of 
the name to change.


Employment Practices

Genentech will continue its current employment practices unless changed 
by the Genentech CEO or the Board.  Roche recognizes the value of 
Genentech's culture and of maintaining Genentech as an integrated 
entity.  It is expected that Genentech will be an integrated, multi-
disciplinary company with all necessary functions.  The Genentech CEO or 
the Board retain the option to manage headcount as is in the best 
interests of Genentech, taking into account the overall interest of 
Genentech's shareholders.

Genentech will maintain an independent and entrepreneurial compensation 
and benefits policy based on reward for success as approved by the 
Genentech CEO or the Board.  In the event that Genentech's stock is no 
longer publicly traded, a replacement incentive program that maintains 
the entrepreneurial approach of Genentech will be implemented. 


Research

Research direction will be set by Genentech's head of research in 
consultation with the Executive Committee and current practices such as 
time allocated to independent research, rapid publication of results to 
permit recognition in the scientific community, and use of post-docs 
will continue.  In addition, Research will seek to remain on the cutting 
edge of related technologies through internal efforts and in-licensing 
of technology, product rights, and collaborations with third parties.  
The current level of Research funding will be maintained unless changed 
by the Genentech Board of Directors or Genentech CEO.  The level of 
Research funding in the future could increase modestly for inflation and 
in-licensing.  Research collaborations between Genentech and Roche will 
be evaluated on the basis of scientific merit and mutual benefit. 
Genentech and Roche will continue to exchange scientific information and 
knowledge to the benefit of both research groups.


Small Molecule Research

Genentech envisions that it will look for partners for most small 
molecule projects and that Roche will be the preferred collaborator 
assuming Roche has adequate resources and interest in such a 
collaboration.  Unless Roche owns 100% of Genentech, appropriate 
business terms will be negotiated.


Development

Through Phase II, Genentech projects will be managed by Genentech's 
Product Development Committee as overseen by the Executive Committee (or 
their successors as established by the Genentech CEO or Board), and the 
Genentech CEO.  At the initiation of Phase I, Roche will review the data 
and the proposed clinical plan.  Approximately four months prior to 
completion of the Phase II trials, or "proof of concept", Genentech will 
supply information to Roche about the product, its proposed development 
and its commercial potential.  Upon successful completion of Phase II, 
or earlier demonstration of  "proof of concept", Roche will be provided 
the results of the trial(s) and related commercial information.  The 
meeting of the Genentech and Roche joint development and commercial 
committee will be scheduled and held. This meeting will be expected to 
review and approve one global development and registration strategy and 
plan to bring any new product to the market as quickly and as 
effectively as possible. The development work will be carried out 
utilizing available resources in both companies with development speed, 
development cost, and commercial potential as main criteria for success.

If Roche decides not to develop and market a product, Genentech will be 
free to develop the product with a partner or out-license it.


Manufacturing

It is anticipated that Genentech will manufacture its large molecules 
and Genentech/Roche jointly developed large molecules and that Roche 
will make Genentech/Roche jointly developed small molecules.  All other 
manufacturing and process technology arrangements will be on a space 
available basis at commercial terms.


Sales and Marketing

Genentech has a highly focused efficient and productive sales and 
marketing organization with in-depth expertise in specialized markets.  
Genentech and Roche intend to preserve the strengths/expertise and the 
culture of this organization to maximize sales and market performance of 
our products.


GENENTECH, INC.                                F. HOFFMANN-LA ROCHE LTD

3





FINANCIAL REVIEW
(dollars in millions, except per share amounts)

RELATIONSHIP WITH ROCHE HOLDINGS, INC.

On October 25, 1995, Genentech, Inc. (the Company) and Roche Holdings, Inc.  
(Roche) entered into a new agreement (the Agreement) to extend until June 30, 
1999, Roche's option to cause the Company to redeem (call) the outstanding 
callable putable common stock (special common stock) of the Company at 
predetermined prices.  Should the call be exercised, Roche will concurrently 
purchase from the Company a like number of common shares for a price equal to 
the Company's cost to redeem the special common stock.  If Roche does not cause 
the redemption as of June 30, 1999, the Company's stockholders will have the 
option to cause the Company to redeem none, some, or all of their shares of 
special common stock (and Roche will concurrently provide the necessary 
redemption funds to the Company by purchasing a like number of shares of common 
stock) within thirty business days commencing July 1, 1999.  See the 
"Relationship with Roche Holdings, Inc." note in the "Notes to Consolidated 
Financial Statements" for further information.

In conjunction with the Agreement, F. Hoffmann-La Roche Ltd (HLR) was granted 
an option for ten years for licenses to use and sell certain of the Company's 
products in non-United States (U.S.) markets.  As a result of the Agreement, in 
1996 the Company's total product sales decreased, while contract and royalty 
revenue increased.  Cost of sales as a percentage of product sales also 
increased due to the Agreement.  See below for further discussion.  


RESULTS OF OPERATIONS
(dollars in millions)
                                                              Annual % Change
Revenues              1996         1995         1994       96/95         95/94
- -------------------------------------------------------------------------------
Revenues           $ 968.6      $ 917.8      $ 795.4         6 %           15%


The increase in revenues in 1996 resulted primarily from higher contract and 
royalty revenue partly offset by lower product sales.  The 1995 increase 
resulted primarily from higher royalty income and product sales.  Product sales 
to HLR in conjunction with the Agreement were $13.2 million in 1996 and $1.8 
million in 1995.

                                                             Annual % Change
Product Sales          1996        1995         1994        96/95       95/94
- ------------------------------------------------------------------------------
Activase           $  284.1    $  301.0      $ 280.9          (6)%         7%
Protropin and
 Nutropin             218.2       219.4        225.4          (1)         (3)
Pulmozyme              76.0       111.3         88.3         (32)         26 
Actimmune               4.5         3.6          6.4          25         (44)  
                    ----------------------------------------------------------
Total product
  sales            $  582.8    $  635.3      $ 601.0          (8)%         6%
% of revenues           60%         69%          76%      


Total product sales decreased in 1996 compared to 1995 primarily as a result of 
the Agreement with Roche.  On a pro forma basis that includes sales to HLR in 
1996 and the fourth quarter of 1995, and excludes Canadian and European 
customer sales in 1995, sales increased to $582.8 million in 1996 from $578.7 
million in 1995.  

Activase:  Total net sales of Activase, registered trademark, in 1996 decreased 
compared to 1995 primarily due to the impact of not having Canadian customer 
sales in 1996 as a result of the Agreement with Roche and the increased use of 
angioplasty (see below).  Activase sales to Canadian customers were $12.7 
million in 1995.  Sales to U.S. customers decreased slightly in 1996 due to a 
decline in the market size.  Although Activase's market share grew to 
approximately 80% in 1996 from approximately 75% in 1995, the overall size of 
the thrombolytic market at year end 1996 declined from 1995 by approximately 
6%.  The decline in the market size was the result of the increasing use of 
angioplasty rather than thrombolytic therapy, as well as from patients 
receiving therapy through ongoing clinical trials.  On a pro forma basis, 
Activase sales were $284.1 million in 1996 versus $288.3 million in 1995, with 
the slight decrease due to lower U.S. sales and lower bulk product sales to 
Japan licensees.  In June 1996, the Company received clearance from the U.S. 
Food and Drug Administration (FDA) to market Activase for the treatment of 
acute ischemic stroke or brain attack.  Activase is the first therapy to be 
indicated for the management of stroke.  The increase in Activase sales in 1995 
over 1994 was attributable to growth in market share and an increase in the 
number of patients receiving thrombolytic therapy in the United States.

Protropin and Nutropin:  Net sales of Protropin, registered trademark, and 
Nutropin, registered trademark, (together, growth hormone) were essentially 
flat in 1996 compared to 1995.  On a pro forma basis, growth hormone sales in 
1996 were $218.2 million compared to $216.7 million in 1995.  The Company 
continues to face increased competition in the growth hormone market.  Three 
companies in 1995, and a fourth company in 1996, received FDA approval to 
market their growth hormone products for treatment of growth hormone inadequacy 
in children, although one of those companies has been preliminarily enjoined 
from selling its product.  Two competitors have received approval to market 
their existing human growth hormone products for additional indications.  
Growth hormone sales decreased in 1995 compared to 1994 due to a slight volume 
increase in sales being more than offset by the impact of pricing programs for 
distribution channels and for the managed care sector.  In December 1996, the 
Company received clearance from the FDA to market Nutropin for the treatment of 
growth failure associated with Turner syndrome.

Pulmozyme:  Net sales of Pulmozyme, registered trademark, in 1996 decreased 
compared to 1995 primarily in conjunction with the Agreement with Roche.  
Pulmozyme sales to customers in Europe and Canada totaled $41.3 million in 
1995.  In 1996, sales in these territories were made by Roche for the full 
year, and the Company received royalties on Roche's sales.  On a pro forma 
basis, Pulmozyme sales were $76.0 million in 1996 compared to $70.0 million in 
1995.  Pulmozyme sales in 1995 increased over 1994 due to market launches in 
additional European countries and continued adoption of the product by 
physicians to treat cystic fibrosis patients.  In December 1996, Pulmozyme was 
cleared for marketing by the FDA for the management of cystic fibrosis patients 
with advanced disease, a condition that affects approximately 500 patients in 
the United States.
   
                                                   
Royalties, Contract and Other,                                 Annual % Change
 and Interest Income               1996       1995       1994   96/95   95/94
- ------------------------------------------------------------------------------

Royalties                      $  214.7   $  190.8   $  126.0      13%     51%

Contract and other                107.0       31.2       25.6     243      22

Interest income                    64.1       60.5       42.8       6      42


The Company receives royalty payments from HLR from its sales of the Company's 
products outside of the U.S. under the Agreement, and receives royalties from 
other licensees and HLR from the sales of various other health care products.  
Total royalties in 1996 increased over 1995 primarily due to new royalties from 
HLR in conjunction with the Agreement, as well as higher income from existing 
licensees due to increased licensee sales.  Royalty revenue under the Agreement 
was $17.0 million in 1996 and $1.9 million in 1995.  All other royalty revenue 
from HLR in 1996, 1995 and 1994, totaled $9.2 million, $10.6 million and $7.9 
million, respectively.  The increase in 1995 compared to 1994 was attributable 
to increases in product sales by various licensees and new royalty 
arrangements.  In 1995, the largest dollar increase was attributable to the 
receipt and recognition of $30.0 million of royalty revenue relating to the 
December 1994 settlement with Eli Lilly and Company (Lilly) regarding certain 
of the Company's patents. Under the December 1994 settlement agreement with 
Lilly, royalties of $30.0 million per year are payable, subject to possible 
offsets and contingent upon Humulin, registered trademark, continuing to be 
marketed in the U.S., to the Company through 1998, at which time such royalty 
obligations expire.  Under a prior license agreement with Lilly, the Company 
receives royalties from Lilly's sales of its human insulin product.  These 
royalty obligations expire in August of 1998.  Cash flows from royalty income 
include non-dollar denominated revenues.  The Company currently purchases 
simple foreign currency put option contracts (options) and enters into foreign 
currency forward exchange contracts (forward contracts) to hedge these cash 
flows.  All options expire within the next four years.  The Company has forward 
contracts of various durations that will expire by the end of 1997.

Contract and other revenues increased in 1996 due to contract revenue from HLR 
for the exercises of their options under the Agreement with respect to the 
development of three projects - IDEC-C2B8, insulin-like growth factor (IGF-1) 
and nerve growth factor (NGF).  The Company recorded non-recurring contract 
revenues of $58.2 million relating to these option exercises in 1996.  All 
other contract revenue from HLR, including reimbursement for ongoing 
development expenses after the option exercise date, totaled $37.1 million in 
1996, $13.4 million in 1995 and $17.1 million in 1994.  The increase in 1995 
compared to 1994 was attributable to $6.4 million of gains recorded from sales 
of biotechnology equity securities.  Contract and other revenues will continue 
to fluctuate due to variations in the timing of contract benchmark 
achievements; the initiation of new contractual arrangements, including the 
potential exercise of product options by HLR; and the conclusion of existing 
arrangements.

Interest income increased in 1996 compared to 1995 due to a larger investment 
portfolio. The increase in 1995 compared to 1994 was attributable to a larger 
investment portfolio and a higher average portfolio yield. The Company enters 
into interest rate swaps as part of its overall strategy of managing the 
duration of its investment portfolio. See the "Financial Instruments" note in 
the "Notes to Consolidated Financial Statements" for further information.


                                                               Annual % Change
Costs and Expenses         1996       1995       1994        96/95       95/94
- -------------------------------------------------------------------------------
Cost of sales            $104.5     $ 97.9     $ 95.8          7%          2%
Research and
  development             471.1      363.0      314.3         30          15
Marketing, general and
  administrative          240.1      251.7      248.6         (5)          1
Special charge                -       25.0          -          -           -
Interest expense            5.0        8.0        7.1        (38)         13
                     ----------------------------------------------------------
Total costs
  and expenses           $820.7    $ 745.6    $ 665.8         10%         12% 
% of revenues               85%        81%        84%          

Cost of sales as % of
  product sales             18%        15%        16%     
R&D as % of revenues        49         40         40      
MG&A as % of revenues       25         27         31      
Cost of Sales:  The cost of sales as a percentage of product sales increased 
in 1996 compared to 1995 primarily due to the impact of lower margin sales to 
HLR in 1996.  The economic benefits from sales to HLR are also reflected in 
royalties as discussed above.  In 1996, 1995 and 1994, reserves of $3.6 
million, $3.7 million and $11.9 million, respectively, were provided for 
expected expirations of certain inventories.

Research and Development:  Research and development (R&D) expense increased 30% 
in 1996 compared to 1995 due to continued late-stage clinical testing of 
products and new development projects.  The increase in 1995 over 1994 resulted 
from a higher level of activity and associated costs of products in the later 
stages of clinical trials and the manufacture of products for clinical trials.

To gain additional access to potential new products and technologies and to 
utilize other companies to help develop the Company's potential new products, 
the Company has established strategic alliances with, including acquiring the 
equity and convertible debt of, companies developing technologies that fall 
outside the Company's research focus and with companies having the potential to 
generate new products through technology exchanges and investments.  The 
Company has also entered into product-specific collaborations to acquire 
development and marketing rights for products.

Marketing, General and Administrative:  Marketing, general and administrative
expenses (MG&A) in 1996 decreased from 1995 primarily due to the closure of the 
Company's European and Canadian operations in conjunction with the Agreement.  
MG&A expenses in 1995 were comparable to the 1994 level of expenses.

Special Charge:  The Company recorded a special charge of $25.0 million in 
1995, which included $21.0 million related to the Agreement with Roche and $4.0 
million associated with the resignation of the Company's former President and 
Chief Executive Officer.  The merger expenses included investment banking fees, 
legal expenses, filing fees and other costs related to the Agreement, as well 
as charges associated with the settlement of stockholder lawsuits filed after 
the transaction was announced.

Interest Expense:  Interest expense in 1996, 1995 and 1994, net of amounts 
capitalized, relates primarily to interest on the Company's 5% convertible 
subordinated debentures.  In 1995, it also included interest on a $25.0 million 
borrowing arrangement which commenced in February 1995 and was paid in December 
of that year.


Income Before Taxes and Income Taxes           1996         1995        1994
- -----------------------------------------------------------------------------

Income before taxes                         $ 147.9      $ 172.2     $ 129.6 

Income tax provision                           29.6         25.8         5.2
Effective tax rate                              20%          15%          4%


The increase in the effective tax rate to 20% in 1996 from 15% in 1995 is due 
to the recognition of a greater amount of tax credit carryforwards in 1995 than 
in 1996.  The net increase in the rate from 1994 to 1995 was primarily related 
to limitations on the utilization of existing carryforwards related to the U.S. 
alternative minimum tax.


                                                              Annual % Change
Net Income                  1996       1995       1994       96/95       95/94
- -------------------------------------------------------------------------------

Net income               $ 118.3    $ 146.4     $124.4       (19)%        18% 
Net income per share     $  0.96    $  1.21     $ 1.04     

Net income in 1996 decreased compared to 1995 primarily due to higher R&D 
expenses and lower product sales, partly offset by increased contract and 
royalty revenue.  Net income in 1995 increased over 1994 due to higher revenue 
from all sources, partly offset by higher expenses, primarily R&D and special 
charges.


LIQUIDITY AND CAPITAL RESOURCES                   1996        1995       1994
- ------------------------------------------------------------------------------

Cash, cash equivalents, short-term investments
   and long-term marketable debt and equity 
   securities                                  $1,159.1    $1,096.8   $ 920.9 
Working capital                                   705.1       812.0     776.6 
Cash provided by (used in):
   Operating activities                           139.7       133.9     200.4
   Investing activities                          (141.7)     (117.7)   (322.3)
   Financing activities                            72.2        54.1      71.2
Capital expenditures
  (included in investing activities above)       (141.8)      (70.2)    (82.8)
Current ratio                                     3.8:1       4.5:1     4.5:1


Cash generated from operations, the maturity of investments and stock issuances 
were used to purchase marketable securities and make capital additions in 1996.

Capital expenditures in 1996 primarily include building and land purchases and 
improvements to existing manufacturing and office facilities. In 1995, the 
Company entered into an arrangement with a lessor for a new manufacturing 
facility which qualifies as an operating lease and is expected to become 
operational in 1998.

FORWARD-LOOKING STATEMENTS

The following section contains forward-looking statements that are based on 
the Company's current expectations.  Because the Company's actual results may 
differ materially from any forward-looking statements made by or on behalf of 
the Company, this section also includes a discussion of important factors that 
could affect the Company's actual future results, including its product sales, 
royalties, contract revenues, expenses and net income.

Total Product Sales:  The Company anticipates that total reported quarterly 
product sales in 1997 will be comparable to 1996; however, product sales will 
be dependent on the overall competitive environment.  Other factors affecting 
the Company's total product sales include, but are not limited to, the amount 
and timing of the Company's sales to HLR, the amount of sales to customers in 
the U.S., increased competition in the growth hormone and thrombolytic 
markets, the timing and amount of bulk shipments to licensees, and the 
possibility of the introduction of a new product in late 1997.

Activase Sales:  The Company faces new competition in the thrombolytic market. 
The Company is aware that one company received FDA approval in October 1996 to 
market its product for the treatment of acute myocardial infarction (AMI) in 
the U.S.  The Company has brought suit against that company for patent 
infringement.  In addition, there is an increasing use of angioplasty in the 
treatment of AMI patients in lieu of the use of thrombolytic therapy.  
Depending on the extent and type of new competition, the Company's total 
Activase sales could be materially affected.  Other factors affecting the 
Company's Activase sales include, but are not limited to, the timing of FDA 
approval, if any, of additional competitive products, pricing decisions made 
by the Company, the outcome of litigation against Boehringer Mannheim GmbH and 
Boehringer Mannheim Corporation involving the Company's patents for tissue 
plasminogen activator and processes related to its production and formulation, 
the increasing use of other therapies such as angioplasty techniques for the 
treatment of AMI, and the impact of the FDA's recent clearance for the Company 
to market Activase for the treatment of acute ischemic stroke.

Growth Hormone Sales:  The Company continues to face the possibility of 
increased competition in the growth hormone market.  Three companies received 
FDA approval in 1995, and a fourth company received FDA approval in October 
1996, to market their growth hormone products for treatment of growth hormone
inadequacy in children, although one of those companies has been preliminarily 
enjoined from selling its product.  Two of the Company's competitors have 
received approval to market their existing human growth hormone products for 
additional indications.  The Company expects such competition to have an 
adverse effect on its sales of Protropin and Nutropin which, depending on the 
extent and type of competition, could be material.  Other factors affecting 
the Company's growth hormone sales include, but are not limited to, the timing 
of FDA approval, if any, of other new competitive products, the outcome of 
litigation involving the Company's patents for human growth hormone and 
related processes, pricing decisions made by the Company, the availability of 
third- party reimbursement for the cost of growth hormone therapy, and the 
impact of Nutropin as a treatment for growth failure associated with Turner 
syndrome.

Pulmozyme Sales:  Factors that may influence the future sales of Pulmozyme 
include, but are not limited to, physician perception of the number and kinds 
of patients who will benefit from such therapy, the availability of third-
party reimbursement for the costs of therapy, the timing of the development of 
alternative therapies for the treatment and care of cystic fibrosis, whether 
and when additional indications are approved, and the cost of therapy.

Royalty and Contract Revenues:  Royalty and contract revenues in future 
periods could vary significantly from 1996 levels.  Major factors affecting 
these revenues include, but are not limited to:  HLR's decisions to exercise 
or not to exercise its option to develop and sell the Company's future 
products in non-U.S. markets and the timing and amount of related development 
cost reimbursement, if any; variations in HLR's sales of Genentech products, 
and other licensees' sales of licensed products; the expiration of royalties 
from Lilly in 1998; fluctuations in foreign currency exchange rates; the 
timing of non-U.S. approvals, if any, for products licensed to HLR; whether 
and when contract benchmarks are achieved; the initiation of other new 
contractual arrangements; and the conclusion of existing arrangements with 
other companies and HLR.

R&D Expenses:  The Company intends to continue its commitment to aggressive 
investment in R&D.  As it continues late-stage clinical testing of products, 
the Company anticipates that its R&D expenses will continue at a high 
percentage of revenues over the short-term.  Over the long-term, however, R&D 
as a percent of revenues should decrease, although in dollar terms R&D 
spending is generally expected to rise as revenues rise. Factors affecting the 
Company's R&D expenses include, but are not limited to: the outcome of 
clinical trials currently being conducted; the number of products entering 
into development from late-stage research; future levels of the Company's 
product sales (including the impact of competition), royalty and contract 
revenues; the possibility of competition with respect to products or 
technologies under development; and decisions by HLR to exercise or not to 
exercise its option to develop and sell potential products of the Company in 
non-U.S. markets and the timing of such decisions.

Income Tax Provision:  The Company expects that its effective tax rate will 
increase from the current rate of 20% to approximately 35% in 1997, and 
continue at or near 35% for the next several years dependent upon several 
factors.  These factors include, but are not limited to, changes in tax laws 
and rates, future levels of R&D spending, the outcome of clinical trials of 
certain development products, the Company's success in commercializing such 
products, and potential competition regarding the products.

Successful Development of Products:  The Company intends to continue to 
develop new products. Successful pharmaceutical product development is highly 
uncertain and is dependent on numerous factors, many of which are beyond the
Company's control. Products that appear promising in the early phases of 
development may fail to reach the market for numerous reasons. They may be
found to be ineffective or to have harmful side effects in preclinical or 
clinical testing, may fail to receive necessary regulatory approvals, may turn 
out to be uneconomical because of manufacturing costs or other factors, or may 
be precluded from commercialization by the proprietary rights of others or by
competing products or technologies for the same indication.  Success in 
preclinical and early clinical trials does not ensure that large-scale 
clinical trials will be successful. Clinical results are frequently 
susceptible to varying interpretations which may delay, limit or prevent 
regulatory approvals. The length of time necessary to complete clinical trials 
and to submit an application for marketing approval for a final decision by a 
regulatory authority varies significantly and may be difficult to predict.

Uncertainties Surrounding Proprietary Rights:  The patent positions of 
pharmaceutical and biotechnology companies can be highly uncertain and involve 
complex legal and factual questions. Accordingly, the breadth of claims 
allowed in such companies' patents cannot be predicted. Patent disputes are 
frequent and can preclude commercialization of products. The Company, as in 
the past, may be involved in future material patent litigation. Such 
litigation is costly in its own right and could subject the Company to 
significant liabilities to third-parties and, if decided adversely, the 
Company may need to obtain third party licenses or cease using the technology 
or product in dispute.  The presence of patents or other proprietary rights 
belonging to other parties may lead to the termination of research and 
development of a particular product. The Company believes it has strong patent 
protection or the potential for strong patent protection for a number of its 
products that generate sales and royalty revenue or that the Company is 
developing; however, the courts will determine the ultimate strength of patent 
protection of the Company's products and those on which the Company earns 
royalties.

Liquidity:  The Company believes that its cash, cash equivalents, and short-
term investments, together with funds provided by operations and leasing 
arrangements, will be sufficient to meet its foreseeable operating cash 
requirements. Factors affecting the Company's cash position include, but are 
not limited to, future levels of the Company's product sales, royalty and 
contract revenues, expenses and capital expenditures.

Market Potential/Risk:  Over the longer term, the Company's (and its 
partners') ability to successfully market current products, expand their 
usage, and bring new products to the marketplace will depend on many factors, 
including, but  not limited to, the effectiveness and safety of the products, 
FDA and foreign regulatory agencies' approvals for new products and new 
indications, and the degree of patent protection afforded to particular 
products.

Roche Holdings, Inc.:  At December 31, 1996, Roche held approximately 66.0% of 
the Company's outstanding common equity.  In January and February 1997, Roche 
purchased additional shares of the Company's common equity increasing Roche's 
holdings to 68.0%.  The Company expects to continue to have material 
transactions with Roche, including royalty and contract development revenues, 
product sales and joint product development.

Foreign Exchange:  The Company receives royalty revenues from countries 
throughout the world.  As a result, the Company's financial results could be 
significantly affected by factors such as changes in foreign currency exchange 
rates or weak economic conditions in the foreign markets in which the 
Company's products are sold.  The Company is exposed to changes in exchange 
rates in Europe, Asia and Canada.  When the U.S. dollar strengthens against 
the currencies in these countries, the U.S. dollar value of non-U.S. dollar-
based revenue decreases; when the U.S. dollar weakens, the U.S. dollar value 
of the non-U.S. dollar-based revenues increases.  Accordingly, changes in 
exchange rates, and in particular a strengthening of the U.S. dollar, may 
adversely affect the Company's royalty revenues as expressed in U.S. dollars.

To mitigate this risk, the Company hedges certain of these anticipated 
revenues by purchasing options with expiration dates and amounts of currency 
that are based on a portion of probable revenues so that the adverse impact of 
movements in currency exchange rates on the non-dollar denominated revenues 
will be at least partly offset by an associated increase in the value of the 
option.  The Company also enters into forward contracts to lock in the dollar 
value of a portion of these anticipated revenues.

Interest Rates:  The Company's interest income is sensitive to changes in the 
general level of U.S. interest rates.  In this regard, changes in U.S. 
interest rates affect the interest earned on the Company's cash equivalents, 
short-term  investments and long-term investments.  To mitigate the impact of 
fluctuations in U.S. interest rates, the Company enters into interest rate 
swap transactions which generally involve the receipt of fixed rate interest 
and the payment of floating rate interest without the exchange of the 
underlying principal.  These agreements have the effect of locking in rates 
for longer periods of time than the duration of short-term investments.

Equity Securities:  As part of its strategic alliance efforts, the Company 
invests in equity instruments that are subject to fluctuations from market 
value changes in stock prices.  To mitigate this risk, certain equity 
securities are hedged with costless collars.  A costless collar is a purchased 
put option and a written call option in which the cost of the purchased put 
and the proceeds of the written call offset each other; therefore, there is no 
initial cost or cash outflow for these instruments at the time of purchase.  
The purchased put protects the Company from a decline in the market value of 
the security below a certain minimum level (the put "strike" level); while the 
call effectively limits the Company's potential to benefit from an increase in 
the market value of the security above a certain maximum level (the call 
"strike" level).

Credit Risk of Counterparties:  The Company could be exposed to losses related 
to the above financial instruments should one of its counterparties default.  
This risk is mitigated through credit monitoring procedures.

Legal Proceedings:  The Company is a party to various legal proceedings 
including patent infringement cases and various cases involving product 
liability and other matters. See the "Leases, Commitments and Contingencies" 
note in the "Notes to Consolidated Financial Statements" for further 
information.
















REPORT OF MANAGEMENT

Genentech, Inc. is responsible for the preparation, integrity and fair
presentation of its published financial statements. The Company has prepared 
the financial statements, presented on pages 51 to 74, in accordance with 
generally accepted accounting principles. As such, the statements include 
amounts based on judgments and estimates made by management. The Company also 
prepared the other information included in the annual report and is 
responsible for its accuracy and consistency with the financial statements.

The financial statements have been audited by the independent auditing firm, 
Ernst & Young LLP, which was given unrestricted access to all financial 
records and related data, including minutes of all meetings of stockholders, 
the Board of Directors and committees of the Board. The Company believes that 
all representations made to the independent auditors during their audit were 
valid and appropriate. Ernst & Young LLP's audit report appears on page 75.

Systems of internal accounting controls, applied by operating and financial 
management, are designed to provide reasonable assurance as to the integrity 
and reliability of the financial statements and reasonable, but not absolute, 
assurance that assets are safeguarded from unauthorized use or disposition, 
and that transactions are recorded according to management's policies and 
procedures. The Company continually reviews and modifies these systems, where 
appropriate, to maintain such assurance. Through the Company's general audit 
activities, the adequacy and effectiveness of the systems and controls are 
reviewed and the resultant findings are communicated to management and the 
Audit Committee of the Board of Directors.

The selection of Ernst & Young LLP as the Company's independent auditors has 
been approved by the Company's Board of Directors and ratified by the 
stockholders. An Audit Committee of the Board of Directors, composed of four 
non-management directors, meets regularly with, and reviews the activities of, 
corporate financial management, the general audit function and the independent 
auditors to ascertain that each is properly discharging its responsibilities. 
The independent auditors and general auditor meet with the Audit Committee, 
with and without management present, to discuss the results of their work, the 
adequacy of internal accounting controls and the quality of financial 
reporting.


Arthur D. Levinson, Ph.D.  Louis J. Lavigne, Jr.      Bradford S. Goodwin
President and              Senior Vice President and  Vice President - Finance
Chief Executive Officer    Chief Financial Officer    and Controller



<TABLE>
<CAPTION>
CONSOLIDATED STATEMENTS OF INCOME
(thousands, except per share amounts)
<S>                                          <C>          <C>          <C>
YEAR ENDED DECEMBER 31                           1996        1995         1994      
- ---------------------------------------------------------------------------------
Revenues
  Product sales (including amounts from
      related parties: 1996-$13,216;
      1995-$1,776; 1994-$0)                  $ 582,829    $ 635,263    $ 601,064
  Royalties (including amounts
      from related parties: 1996-$26,240;
      1995-$12,492; 1994-$8,454)               214,702      190,811      126,022
  Contract and other (including amounts
      from related parties: 1996-$95,299;
      1995-$13,448; 1994-$17,106)              107,037       31,209       25,556
  Interest                                      64,110       60,562       42,748
                                             -----------------------------------

      Total revenues                           968,678      917,845      795,390

Costs and expenses
  Cost of sales (including amounts from
      related parties:  1996-$10,900;
      1995-$6,963; 1994-$0)                    104,527       97,930       95,829
  Research and development (including
      contract related: 1996-$37,051;
      1995-$17,124; 1994-$7,584)               471,143      363,049      314,322
  Marketing, general and administrative        240,063      251,653      248,604
  Special charge (primarily merger related)         --       25,000          --
  Interest                                       5,010        7,940        7,058
                                            ------------------------------------

      Total costs and expenses                 820,743      745,572      665,813


Income before taxes                            147,935      172,273      129,577
Income tax provision                            29,587       25,841        5,183
                                            ------------------------------------

Net income                                   $ 118,348    $ 146,432    $ 124,394
                                            ====================================

Net income per share                         $    0.96    $    1.21    $    1.04
                                            ====================================

Weighted average number of shares used
  in computing per share amounts               123,695      121,220      119,465
                                            ====================================

<FN>
               See Notes to Consolidated Financial Statements.
</TABLE>











<TABLE>
<CAPTION>
CONSOLIDATED STATEMENTS OF CASH FLOWS
(thousands)
                                                            Increase (Decrease) in Cash and
                                                                    Cash Equivalents
YEAR ENDED DECEMBER 31                                         1996       1995       1994
- -------------------------------------------------------------------------------------------
<S>                                                      <C>          <C>        <C>
Cash flows from operating activities:
  Net income                                              $ 118,348   $ 146,432  $ 124,394 
Adjustments to reconcile net income to
   net cash provided by operating activities:
         Depreciation and amortization                       62,124      58,421     53,452
         Writedown of securities available-for-sale               -       6,609     12,590
         Gain on sales of securities available-for-sale        (347)     (7,432)         -
         Deferred income taxes                              (34,021)    (22,655)   (34,193)
         Loss on fixed asset dispositions 
            (including merger-related in 1995)                5,309       1,032      5,510
         Other                                                    -        (234)       748
  Changes in assets and liabilities:
         Net cash flow from trading securities               (8,184)    (50,014)    (4,634)
         Receivables and other current assets               (30,416)    (28,446)   (11,937)
         Inventories                                          1,705       9,552    (18,475)
         Accounts payable, other current
            liabilities and other long-term
            liabilities                                      25,153      20,682      72,901
                                                          ----------------------------------
  Net cash provided by operating activities                 139,671     133,947     200,356

Cash flows from investing activities: 
  Purchases of securities held-to-maturity                 (634,124)   (682,396) (1,088,737)
  Proceeds from maturities of securities 
     held-to-maturity                                       772,922     924,345     877,139
  Purchases of securities available-for-sale               (304,806)   (353,118)    (22,644)
  Proceeds from sales of securities available-
     for-sale                                               182,564     101,591           -
  Purchases of non-marketable equity securities              (9,323)          -      (4,000)
  Capital expenditures                                     (141,837)    (70,166)    (82,837)
  Change in other assets                                     (7,046)    (37,948)     (1,198)
                                                         ------------------------------------
  Net cash used in investing activities                    (141,650)   (117,692)   (322,277)

Cash flows from financing activities:
  Stock issuances                                            72,558      54,946      71,955
  Reduction in long-term debt,
     including current portion                                 (358)       (871)       (794)
                                                         ------------------------------------
  Net cash provided by financing activities                  72,200      54,075      71,161
                                                         ------------------------------------
Increase (decrease) in cash and cash equivalents             70,221      70,330     (50,760)
Cash and cash equivalents at beginning of year              137,043      66,713     117,473
                                                         ------------------------------------
Cash and cash equivalents at end of year                  $ 207,264   $ 137,043   $  66,713
                                                         ====================================
Supplemental cash flow data:
  Cash paid during the year for:
      Interest, net of portion capitalized                $   5,010   $   7,917   $   7,058
      Income taxes                                           52,243      44,699       4,099

<FN>

                 See Notes to Consolidated Financial Statements.
</TABLE>








<TABLE>
<CAPTION>
CONSOLIDATED BALANCE SHEETS
(dollars in thousands)

DECEMBER 31                                               1996            1995
- --------------------------------------------------------------------------------
<S>                                                <C>             <C>
Assets:
Current assets:
  Cash and cash equivalents                         $   207,264     $   137,043
  Short-term investments                                415,900         603,296
  Accounts receivable - trade (net of
      allowances of: 1996-$4,110; 1995-$4,579)           77,785          87,694
  Accounts receivable - other (net of
      allowances of: 1996-$3,759; 1995-$2,093)           86,450          65,185
  Accounts receivable - related party                    33,377          19,281
  Inventories                                            91,943          93,648
  Prepaid expenses and other current assets              42,365          39,267
                                                  -----------------------------
      Total current assets                              955,084       1,045,414

Long-term marketable securities                         535,916         356,475
Property, plant and equipment, net                      586,167         503,654
Other assets                                            149,205         105,452
                                                  -----------------------------
Total assets                                        $ 2,226,372     $ 2,010,995
                                                  =============================
Liabilities and stockholders' equity:
Current liabilities:
  Accounts payable                                  $    45,501     $    37,101
  Accrued liabilities - related party                     9,908           8,745
  Other accrued liabilities                             194,542         187,598
                                                  -----------------------------
      Total current liabilities                         249,951         233,444
Long-term debt                                          150,000         150,000
Other long-term liabilities                              25,362          25,504
                                                  -----------------------------
Total liabilities                                       425,313         408,948
Commitments and contingencies
Stockholders' equity:
  Preferred stock, $.02 par value; authorized:
      100,000,000 shares; none issued                         -               -
  Special common stock, $.02 par value;
      authorized: 100,000,000 shares; outstanding:
      1996-44,805,755; 1995-42,646,958                      896             853
  Common stock, $.02 par value;
      authorized: 200,000,000 shares;
      outstanding: 1996 and 1995-76,621,009               1,532           1,532
  Additional paid-in capital                          1,362,585       1,281,640
  Retained earnings (since October 1, 1987
      quasi-reorganization)                             382,097         263,749
  Net unrealized gain on securities
      available-for-sale                                 53,949          54,273
                                                 -------------------------------
      Total stockholders' equity                      1,801,059       1,602,047
                                                 -------------------------------
Total liabilities and stockholders' equity          $ 2,226,372     $ 2,010,995
                                                 ===============================

<FN>
               See Notes to Consolidated Financial Statements.
</TABLE>







<TABLE>
<CAPTION>
                              CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY
                                                 (thousands)

                                             1996                  1995                 1994
Year ended December 31               -------------------   -------------------   -------------------
                                      Shares     Amount     Shares     Amount     Shares     Amount
                                     --------  ---------   --------  ---------   --------  ---------
<S>                                  <C>        <C>        <C>       <C>         <C>       <C>
Special common stock
  Beginning balance                   42,647     $  853          -          -          -          -
  Issuance of stock upon exercise
    of options and warrants            2,159         43        298      $   6          -          -
  Conversion of common stock
    to special common stock                -          -     42,349        847          -          -
                                     ---------------------------------------------------------------
  Ending balance                      44,806        896     42,647        853          -          -
                                     ---------------------------------------------------------------
  
Redeemable common stock
  Beginning balance                        -          -     50,106      1,002     47,690      $ 954
  Issuance of stock upon exercise
    of options and warrants                -          -        679         14      1,905         38
  Issuance of stock under
    employee stock plan                    -          -        322          6        511         10
  Conversion of redeemable 
    common stock to common stock           -          -    (51,107)    (1,022)         -          -
                                     ---------------------------------------------------------------
  Ending balance                           -          -          -          -     50,106      1,002
                                     ---------------------------------------------------------------
Common stock
  Beginning balance                   76,621      1,532     67,133      1,343     67,133      1,343
  Issuance of stock upon exercise
    of options and warrants                -          -        512         10          -          -
  Issuance of stock under
    employee stock plan                    -          -        218          4          -          -
  Conversion of redeemable
    common stock to common stock           -          -     51,107      1,022          -          -
  Conversion of common stock 
    to special common stock                -          -    (42,349)      (847)         -          -
                                     ---------------------------------------------------------------
  Ending balance                      76,621      1,532     76,621      1,532     67,133      1,343
                                     ---------------------------------------------------------------
Additional paid-in capital 
  Beginning balance                           1,281,640             1,207,720             1,070,121
  Issuance of stock upon exercise
    of options and warrants                      55,103                37,087                56,133
  Issuance of stock under
    employee stock plan                          17,412                17,819                15,774
  Income tax benefits
    realized from employee
    stock option exercises                        8,430                 7,204                26,038
  Tax benefits arising prior
    to quasi-reorganization                           -                11,810                39,654
                                             ----------            ----------           -----------
  Ending balance                              1,362,585             1,281,640             1,207,720
                                             ----------            -----------          -----------
Retained earnings 
  Beginning balance                             263,749               129,127                44,387
  Net income                                    118,348               146,432               124,394
  Tax benefits arising prior
    to quasi-reorganization                           -               (11,810)              (39,654)
                                             ----------            ----------           -----------
  Ending balance                                382,097               263,749               129,127
                                             ----------            ----------           -----------
Net unrealized gain on securities
  Beginning balance                              54,273                 9,592                     -
  Net unrealized (loss) gain on 
    securities available-for-sale                  (324)               44,681                 9,592
                                             ----------            ----------            ----------

  Ending balance                                 53,949                54,273                 9,592
                                             ----------            ----------            ----------

Total stockholders' equity                   $1,801,059            $1,602,047            $1,348,784
                                             ==========            ==========            ==========
<FN>
                               See Notes to Consolidated Financial Statements.
</TABLE

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

DESCRIPTION OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES

Description of Business:  Genentech, Inc. (the Company) is a biotechnology 
company that discovers, develops, manufactures and markets human 
pharmaceuticals produced by recombinant DNA technology for significant unmet 
medical needs.  The Company manufactures and markets six products directly in 
the United States (U.S.) and sells these products to F. Hoffmann-La Roche Ltd 
(HLR) for HLR to sell outside of the United States.  Of these six products, 
HLR has the right to sell five in Canada and one in a number of countries.  In 
addition, the Company receives royalties from HLR's sales of these products, 
and receives royalties from HLR and other licensees from sales of five other 
products which originated from the Company's technology.

Principles of Consolidation:  The consolidated financial statements include the 
accounts of the Company and all significant subsidiaries and collaborations. 
Material intercompany balances and transactions are eliminated. 

Use of Estimates:  The preparation of financial statements in conformity with 
generally accepted accounting principles requires management to make estimates 
and assumptions that affect the amounts reported in the financial statements 
and accompanying notes.  Actual results could differ from those estimates.

Cash and Cash Equivalents:  The Company considers all highly liquid debt
instruments purchased with an original maturity of three months or less to be
cash equivalents.

Short-term Investments and Long-term Marketable Securities:  The Company
invests its excess cash balances in short-term and long-term marketable 
securities, primarily corporate notes, certificates of deposit and treasury 
notes.  As part of its strategic alliance efforts, the Company also invests in 
equity securities and convertible debt of other biotechnology companies.

Investment securities are classified into one of three categories:  held-to-
maturity, available-for-sale, or trading.  Securities are considered held-to-
maturity when the Company has the positive intent and ability to hold the 
securities to maturity.  These securities are recorded as either short-term 
investments or long-term marketable securities on the balance sheet depending 
upon their contractual maturity dates. Held-to-maturity securities are stated 
at amortized cost, including adjustment for amortization of premiums and 
accretion of discounts.  Securities are considered trading when bought 
principally for the purpose of selling in the near term.  These securities are 
recorded as short-term investments and are carried at market value.  
Unrealized holding gains and losses on trading securities are included in 
interest income.  Securities not classified as held-to-maturity or as trading 
are considered available-for-sale.  These securities are recorded as either 
short-term investments or long-term marketable securities and are carried at 
market value with unrealized gains and losses included in stockholders' 
equity. If a decline in fair value below cost is considered other than 
temporary, such securities are written down to estimated fair value with a 
charge to marketing, general and administrative expenses.  The cost of all 
securities sold is based on the specific identification method.

Property, Plant and Equipment:  The costs of buildings and equipment are
depreciated using the straight-line method over the following estimated useful 
lives of the assets: buildings - 25 years; certain manufacturing equipment - 
15 years; other equipment - 4 or 8 years; leasehold improvements - length of 
applicable lease.  The costs of repairs and maintenance are expensed as 
incurred.  Repairs and maintenance expenses for the years ended December 31, 
1996, 1995 and 1994, were $28.8 million, $22.1 million and $19.2 million, 
respectively.  Interest on construction-in-progress of $2.5 million in 1996, 
$1.5 million in 1995 and $0.6 million in 1994 has been capitalized and is 
included in property, plant and equipment.

Property, plant and equipment balances at December 31 are summarized below 
(thousands):
                                                    1996             1995
     ---------------------------------------------------------------------
     At cost:
       Land                                    $  67,619         $  57,313
       Buildings                                 297,888           258,717
       Equipment                                 428,738           383,387
       Leasehold improvements                     12,314            12,508
       Construction in progress                   99,708            60,480
                                              -----------------------------
                                                 906,267           772,405 
     Less: accumulated depreciation              320,100           268,751
                                              -----------------------------
     Net property, plant and equipment         $ 586,167         $ 503,654
                                              =============================

Patents and Other Intangible Assets:  As a result of its research and 
development (R&D) programs, the Company owns or is in the process of applying 
for patents in the U.S. and other countries which relate to products and 
processes of significant importance to the Company. Costs of patents and 
patent applications are capitalized and amortized on a straight-line basis 
over their estimated useful lives of approximately 12 years.  Intangible 
assets are generally amortized on a straight-line basis over their estimated 
useful lives.

Contract Revenue:  Contract revenue for R&D is recorded as earned based on the 
performance requirements of the contract. In return for contract payments, 
contract partners may receive certain marketing and manufacturing rights, 
products for clinical use and testing, or R&D services.

Royalty Expenses:  Royalty expenses directly related to product sales are 
classified in cost of sales.  Other royalty expenses, relating to royalty 
revenue, totaled $36.0 million, $30.2 million and $26.5 million in 1996, 1995 
and 1994, respectively, and are classified in marketing, general and 
administrative expenses.

Advertising Expenses:  The Company expenses the costs of advertising as 
incurred.  Advertising expenses for the years ended December 31, 1996, 1995 
and 1994, were $28.0 million, $29.2 million and $44.2 million, respectively.

Income Taxes:  The Company accounts for income taxes by the asset and 
liability approach for financial accounting and reporting of income taxes.  
The Company's method of accounting for operating loss and tax credit 
carryforwards arising prior to the date of the Company's quasi-reorganization 
in 1987 is described in the "Quasi-Reorganization" note.

Net Income Per Share:  Net income per share is computed based on the weighted
average number of shares of the Company's special common stock, common stock 
and common stock equivalents, if dilutive.

Financial Instruments:  The Company purchases simple foreign currency put 
options (options) with expiration dates and amounts of currency that are based 
on a portion of probable non-dollar revenues so that the potential adverse 
impact of movements in currency exchange rates on the non-dollar denominated 
revenues will be  at least partially offset by an associated increase in the 
value of the options.  See the "Financial Instruments" note for further 
discussion.  At the time the options are purchased they have little or no 
intrinsic value.  Realized and unrealized gains related to the options are 
deferred until the designated hedged revenues are recorded. The associated 
costs, which are deferred and classified as other current assets, are 
amortized over the term of the options and recorded as a reduction of the 
hedged revenues.  Realized gains and losses are recorded in the income 
statement with the related hedged revenues.  The Company also enters into 
foreign currency forward contracts (forward contracts) as hedging instruments.  
Forward contracts are recorded at fair value, and any gains and losses from 
these forward contracts are recorded in the income statement with the related 
hedged revenues.  Financial instruments, such as forward contracts, not 
qualifying as hedges under generally accepted accounting principles are marked 
to market with gains or losses recorded in income as they occur.

Interest rate swaps have been used and may be used in the future to adjust the 
duration of the investment portfolio in order to meet  duration targets.  
Interest rate swaps are contracts in which two parties agree to swap future 
streams of payments over a specified period.  See the "Financial Instruments" 
note for further discussion.  Net payments made or received on swaps are 
included in interest income as adjustments to the interest received on invested 
cash.  Amounts deferred on terminated swaps are classified as other assets and 
are amortized to interest income over the original contractual term of the 
swaps by a method that approximates the level-yield method.

The Company's marketable equity portfolio consists primarily of biotechnology 
companies whose risk of market fluctuations is greater than the stock market 
in general.  To manage this risk, the Company enters into certain costless 
collar instruments to hedge certain equity securities against changes in 
market value. See the "Financial Instruments" note for further discussion.  
Gains and losses on these instruments are recorded as an adjustment to 
unrealized gains and losses on marketable securities with a corresponding 
receivable or payable recorded in long-term other assets or long-term 
liabilities.

401(k) Plan:  The Company's 401(k) plan (Plan) covers substantially all of its 
U.S. employees. Under the Plan, eligible employees may contribute up to 15% of 
their eligible compensation, subject to certain Internal Revenue Service 
restrictions. The Company matches a portion of employee contributions, up to a 
maximum of 4% of each employee's eligible compensation. The match is effective 
December 31 of each year and is fully vested when made. During 1996, 1995 and 
1994, the Company provided $6.1 million, $5.6 million and $5.2 million, 
respectively, for the Company match under the Plan.

New Accounting Standards:  On January 1, 1996, the Company adopted Statement 
of Financial Accounting Standards (FAS) 121, "Accounting for the Impairment of 
Long-Lived Assets and for Long-Lived Assets to Be Disposed Of," which requires 
the Company to review for impairment of long-lived assets, certain 
identifiable intangibles, and goodwill related to those assets whenever events 
or changes in circumstances indicate that the carrying amount of an asset may 
not be recoverable.  In certain situations, an impairment loss would be 
recognized.  The adoption of FAS 121 did not have a material impact on the 
financial position, results of operations or cash flows of the Company.

In 1996, the Company also implemented the disclosure requirements of FAS 123 
"Accounting for Stock-Based Compensation" (FAS 123).  Under FAS 123, the 
Company will continue to account for stock-based employee compensation 
arrangements under the intrinsic value method prescribed by Accounting 
Principles Board  Opinion 25 "Accounting for Stock Issued to Employees" (APB 
25), and will provide pro forma disclosures of net income and earnings per 
share as if the fair value basis method prescribed by FAS 123 had been applied 
in measuring employee compensation expense.  See the "Capital Stock" note for 
such disclosure.










Inventories:  Inventories are stated at the lower of cost or market. Cost is 
determined using a weighted-average approach which approximates the first-in, 
first-out method.  Inventories at December 31, 1996 and 1995 are summarized 
below (thousands):
                                                     1996        1995
     ------------------------------------------------------------------

     Raw materials and supplies                   $ 17,971    $ 12,808
     Work in process                                61,368      67,239
     Finished goods                                 12,604      13,601
                                                 ----------------------
     Total                                        $ 91,943    $ 93,648
                                                 ======================

Reclassifications:  Certain reclassifications of prior year amounts have been 
made to conform with the current year presentation.

SIGNIFICANT CUSTOMER AND GEOGRAPHIC INFORMATION

HLR contributed approximately 14% of the Company's total revenues in 1996, and 
contributed less than 10% in 1995 and 1994.  See the "Related Party 
Transactions" note below for further information.  Two major customers, 
Caremark, Inc. and Bergen Brunswig, contributed 10% or more of the Company's 
total revenues.  Caremark, Inc., which accounted for 15%, 18% and 21% of total 
revenues in 1996, 1995 and 1994, respectively, distributes Protropin, 
Nutropin, Pulmozyme and Actimmune through its extensive branch network and is 
then reimbursed through a variety of sources.  Bergen Brunswig, a wholesale 
distributor of all of the Company's products, contributed 10% of revenues in 
1996 and 11% in each of the years 1995 and 1994.

Approximate foreign sources of revenues were as follows (millions):

                         1996       1995        1994
- -----------------------------------------------------

Europe                 $146.4     $112.0       $81.8
Asia                     17.8       23.6        19.5
Canada                   11.1       25.0         9.7


The Company currently sells primarily to distributors and hospitals throughout 
the U.S., performs ongoing credit evaluations of its customers' financial 
condition and generally requires no collateral. In 1996, 1995 and 1994, the 
Company did not record any material additions to, or losses against, its 
provision for doubtful accounts.

RESEARCH AND DEVELOPMENT ARRANGEMENTS

To gain access to potential new products and technologies and to utilize other 
companies to help develop the Company's potential new products, the Company has 
established strategic alliances with, including the acquisition of both 
marketable and non-marketable equity investments and convertible debt in,  
companies developing technologies that fall outside the Company's research 
focus and with companies having the potential to generate new products through 
technology exchanges and investments. Potential future payments may be due to 
certain collaborative partners if the partners achieve certain benchmarks as 
defined in the collaborative agreements.  The Company has also entered into 
product-specific collaborations to acquire development and marketing rights 
for products.






SPECIAL CHARGE

The $25.0 million special charge in 1995 includes $21.0 million related to the 
merger agreement (the Agreement) with Roche Holdings, Inc. (Roche), discussed 
in the note "Relationship with Roche Holdings, Inc.," and $4.0 million of 
charges associated with the resignation of the Company's former President and 
Chief Executive Officer.  The merger expenses include legal expenses, 
investment banking fees, filing fees and other costs related to the Agreement 
with Roche, as well as charges associated with the settlement of stockholder 
lawsuits filed after the transaction was announced.

INCOME TAXES

The income tax provision consists of the following amounts (thousands):

                                1996       1995        1994
- ----------------------------------------------------------------
Current:
  Federal                    $ 61,502   $ 43,997    $ 38,331
  State                         2,104      4,467       1,016
  Foreign                           2         32          29
                            ------------------------------------
     Total current             63,608     48,496      39,376
                            ------------------------------------
Deferred:
  Federal                     (34,021)   (12,319)    (34,193)
  State                             -    (10,336)          -
                            ------------------------------------
     Total deferred           (34,021)   (22,655)    (34,193)
                            ------------------------------------
Total income tax provision   $ 29,587   $ 25,841    $  5,183
                            ====================================

Actual current tax liabilities are lower than reflected above by $8.4 million, 
$7.2 million and $26.0 million in 1996, 1995 and 1994, respectively, due to 
employee stock option related tax benefits which were credited to 
stockholders' equity.

A reconciliation between the Company's effective tax rate and the U.S. 
statutory rate follows:

</TABLE>
<TABLE>
<CAPTION>
                                        1996 Amount             Tax Rate
                                        (thousands)    1996        1995       1994
- ------------------------------------------------------------------------------------
<S>                                      <C>          <C>        <C>         <C>  
Tax at U.S. statutory rate               $ 51,777      35.0%       35.0%      35.0%
Operating losses utilized                       -         -           -      (45.6)
Research and development
  credits realized                         (4,500)     (3.0)      (15.9)         -
Alternative minimum tax liability               -         -           -       24.6
Adjustment of deferred tax assets 
  valuation allowance                     (22,566)    (15.3)      (13.1)     (26.4)
Foreign losses (benefited) not benefited   (5,050)     (3.4)        2.8       15.0
State taxes                                 3,368       2.3         2.6        0.8
Other                                       6,558       4.4         3.6        0.6
                                         -------------------------------------------
Income tax provision                     $ 29,587      20.0%       15.0%       4.0%
                                         ===========================================
</TABLE>

The components of deferred taxes consist of the following at December 31 
(thousands):

                                                         1996           1995
- -----------------------------------------------------------------------------
Deferred tax liabilities:
   Depreciation                                        $ 58,842      $ 50,010 
   Unrealized gain on sale of securities 
     available-for-sale                                  21,017        21,204
   Other                                                 10,543         3,109
                                                   --------------------------

      Total deferred tax liabilities                     90,402        74,323

Deferred tax assets:
   Capitalized research and development costs            34,280             -
   Federal credit carryforwards                         111,400       107,350
   Expenses not currently deductible                     38,368        39,433
   State credit carryforwards                            26,710        32,147
   Other                                                  6,340         5,058
                                                   -------------------------- 

      Total deferred tax assets                         217,098       183,988

      Valuation allowance                               (35,827)      (52,817)
                                                   --------------------------

      Total net deferred tax assets                     181,271       131,171
                                                   --------------------------

Total net deferred taxes                              $  90,869      $ 56,848
                                                   ==========================


Total tax credit carryforwards of $138.1 million expire in the years 1997 
through 2012, except for $43.0 million of alternative minimum tax credits which 
have no expiration date.  The valuation allowance at December 31, 1996, 
reflected above relates to the tax benefits of stock option deductions which 
will be credited to additional paid-in capital when realized.

The valuation allowance decreased by $17.0 million in 1996,  $31.6 million in 
1995 and $38.5 million in 1994.. Realization of net deferred taxes depends on 
future earnings from existing and new products and new indications for existing 
products. The timing and amount of future earnings will depend on continued 
success in marketing and sales of the Company's current products, as well as 
the scientific success, results of clinical trials and regulatory approval of 
products under development.

















INVESTMENT SECURITIES

Securities classified as trading, available-for-sale and held-to-maturity at 
December 31, 1996 and 1995 are summarized below. Estimated fair value is based 
on quoted market prices for these or similar investments.

                                             Gross        Gross      Estimated
                                Amortized  Unrealized   Unrealized     Fair
December 31, 1996                  Cost      Gains        Losses       Value
- ------------------------------------------------------------------------------
                                                  (thousands)
TOTAL TRADING SECURITIES
 (carried at estimated
 fair value)                    $ 144,460   $  1,932    $ (2,897)    $ 143,495
                                ==============================================
SECURITIES AVAILABLE-FOR-SALE
 (carried at estimated 
  fair value):
Equity securities               $  42,773   $ 56,347    $ (1,376)    $  97,744
U.S. Treasury securities
  and obligations of other
  U.S. government agencies 
  maturing within:
       1 year                      51,179          -         (71)       51,108
       1-5 years                  103,057      1,299        (209)      104,147
       5-10 years                 113,176      1,001      (2,114)      112,063
Other debt securities 
  maturing within:
       1 year                      46,583         27           -        46,610
       1-5 years                   43,954        185         (94)       44,045
                                ----------------------------------------------
TOTAL AVAILABLE-FOR-SALE        $ 400,722   $ 58,859    $ (3,864)    $ 455,717
                                ==============================================

SECURITIES HELD-TO-MATURITY*
 (carried at amortized cost):
U.S. Treasury securities
  and obligations of other
  U.S. government agencies
  maturing within:
       1 year                   $  76,718   $     31           -     $  76,749
       5-10 years                  30,155          -    $   (777)       29,378
Other debt securities
  maturing within:
       1 year                      91,664          4         (35)       91,633
       1-5 years                  141,553        576         (27)      142,102
                                ----------------------------------------------
TOTAL HELD-TO-MATURITY          $ 340,090   $    611    $   (839)    $ 339,862
                                ==============================================















                                             Gross        Gross      Estimated
                                Amortized  Unrealized   Unrealized     Fair
December 31, 1995                  Cost      Gains        Losses       Value
- ------------------------------------------------------------------------------
                                                  (thousands)
TOTAL TRADING SECURITIES
 (carried at estimated
 fair value)                    $135,325    $ 1,314     $ (1,328)    $135,311 
                                ==============================================
SECURITIES AVAILABLE-FOR-SALE
 (carried at estimated 
  fair value):
Equity securities               $ 22,423    $ 45,894    $   (350)    $ 67,967
U.S. Treasury securities
  and obligations of other
  U.S. government agencies 
  maturing within:
       1 year                      7,503          17           -        7,520
       1-5 years                 162,322       7,103           -      169,425
       5-10 years                 83,188         437           -       83,625
Other debt securities 
  maturing within
       1-5 years                  29,868       1,172           -       31,040
                                ----------------------------------------------
TOTAL AVAILABLE-FOR-SALE        $305,304    $ 54,623    $   (350)    $359,577
                                ==============================================

SECURITIES HELD-TO-MATURITY*
 (carried at amortized cost)
  maturing within 1 year:
U.S. Treasury securities
  and obligations of other
  U.S. government agencies      $219,267    $    318    $    (53)    $219,532
Other debt securities            236,870          95        (297)     236,668
                                ----------------------------------------------
TOTAL HELD-TO-MATURITY          $456,137    $    413    $   (350)    $456,200
                                ==============================================

*  Interest rate swap arrangements are used to modify the duration of certain 
   held-to-maturity securities.  The average effective maturity of the
   portfolio was 2.5 years and 2.7 years at December 31, 1996 and 1995, 
   respectively.  See "Financial Instruments" note for further information.


The carrying value of all investment securities held at December 31, 1996 and 
1995 is summarized below (thousands):

 Security                                                   1996         1995
- ------------------------------------------------------------------------------
Trading securities                                        $143,495    $135,311
Securities available-for-sale maturing within one year      97,718       7,520
Securities held-to-maturity maturing within one year       168,382     456,137
Accrued interest                                             6,305       4,328
                                                          --------    --------
     Total short-term investments                         $415,900    $603,296
                                                          ========    ========

Securities available-for-sale maturing within 1-10 years,
  including equity securities                             $357,999    $352,057
Securities held-to-maturity maturing within 1-10 years     171,708           -
Accrued interest                                             6,209       4,418
                                                          --------    --------
     Total long-term marketable securities                $535,916    $356,475
                                                          ========    ========

In 1996, proceeds from sales of available-for-sale securities totaled $182.6 
million; gross realized gains totaled $1.0 million and gross realized losses 
totaled $0.7 million.  In 1995, proceeds from sales of available-for-sale 
securities totaled $101.6 million; gross realized gains totaled $7.6 million 
and gross realized losses totaled $0.2 million.  During 1994, no available-for-
sale securities were sold.  The Company recorded charges in 1995 and 1994 of 
$6.6 million and $12.6 million, respectively, to write down certain available-
for-sale biotechnology equity securities for which the decline in fair value 
below cost was other than temporary.

During the year ended December 31, 1996, net unrealized holding losses on 
trading securities included in net income totaled $1.0 million.  In 1995 and 
1994, such losses were not material.

Marketable debt securities held by the Company are issued by a diversified 
selection of corporate and financial institutions with strong credit ratings. 
The Company's investment policy limits the amount of credit exposure with any 
one institution. These debt securities are generally not collateralized. The 
Company has not experienced any material losses due to credit impairment on 
its investments in marketable debt securities in the years 1996, 1995 and 
1994.

FINANCIAL INSTRUMENTS

Foreign Currency Instruments:  Certain of the Company's revenues are earned 
outside of the United States.  Moreover, the Company's foreign currency 
denominated revenues exceed its foreign currency denominated expenses; 
therefore, risk exists that net income may be impacted by changes in the 
exchange rates between the U.S. dollar and foreign currencies.  To hedge 
anticipated non-dollar denominated net revenues, the Company currently 
purchases options and enters into forward contracts.  At December 31, 1996, 
the Company had hedged approximately 90% of probable net foreign revenues 
anticipated within 12 months and between 20% and 45% of its probable net 
foreign revenues through 2000.  At December 31, 1996 and 1995, the notional 
amount of the options totaled $100.3 million and $72.8 million, respectively, 
and consisted of the following currencies:  Australian dollars, Canadian 
dollars, German marks, Spanish pesetas, French francs, British pounds, Italian 
lire, Japanese yen, and Swedish krona.  All option contracts mature within the 
next four years.  The fair value of the options, which is based on exchange 
rates and market conditions at December 31, 1996 and 1995, totaled $7.3 
million and $6.3 million, respectively.  At December 31, 1996 and 1995, the 
U.S. dollar equivalent of the notional amount of the forward sell contracts 
was $34.3 million and $6.0 million, respectively, and the forward buy 
contracts totaled $0.4 million and $6.2 million, respectively.

Credit exposure is limited to the unrealized gains on these contracts. All 
agreements are with a diversified selection of institutions with strong credit 
ratings which minimizes risk of loss due to nonpayment from the counterparty.
The Company has not experienced any losses due to credit impairment of its 
foreign currency instruments.

Interest Rate Swaps:  Interest income is subject to fluctuations as U.S. 
interest rates change. To manage this risk, the Company periodically 
establishes duration targets for its investment portfolio that reflect its 
anticipated use of cash and fluctuations in market rates of interest.  The 
Company enters into interest rate swaps (swaps) as part of its overall 
strategy of managing the duration of its cash portfolio.  For each swap, the 
Company receives interest based on fixed rates and pays interest to 
counterparties based on floating rates (three- or six- month London Inter-Bank 
Offered Rate (LIBOR)) on a notional principal amount.  By designating a swap 
with a pool of short-term securities equal in size to the notional amount of 
the swap, an instrument with an effective interest rate and maturity equal to 
the term of the swap is created.  Increases (decreases) in swap variable 
payments caused by rising (falling) interest rates will be essentially offset 
by increased (reduced) interest income on the related short-term investments, 
while the fixed rate payments received from the swap counterparty establish 
the Company's interest income.  LIBOR payments received on swaps are highly 
correlated to interest collections on short-term investments.  The use of 
swaps in this manner generates net interest income on the swap and the 
associated pool of short-term securities equivalent to interest income that 
would be earned from a high-grade corporate security of the same maturity as 
the swap, while reducing credit risk (there is no principal invested in a 
swap). The Company's credit exposure on swaps is limited to the value of the 
interest rate swaps that have become favorable to the Company and any net 
interest earned but not yet received. The Company's swap counterparties have 
strong credit ratings which minimize the risk of non-performance on the swaps. 
The Company has not experienced any material losses due to credit impairment.  
The Company's credit exposure on swaps as of December 31, 1996 and 1995, was 
$6.8 million and $24.1 million, respectively.  The net carrying amount of the 
swaps, which reflects the net interest accrued for such swaps, totaled $2.1 
million and $7.2 million at December 31, 1996 and 1995, respectively, and is 
included in accounts receivable.

The Company targets the average maturity of its investment portfolio 
(including cash, cash equivalents, short-term and long-term investments, 
swaps, and excluding equity securities) based on its anticipated use of cash 
and fluctuations in the market rates of interest. The maturity of the 
investment portfolio (including swaps) ranges from overnight funds used for 
near-term working capital purposes to investments maturing within the next one 
to ten years for future working capital, capital expenditures, strategic 
investments and debt repayment.  

The notional amount of each swap is equal to the amount of designated high- 
quality short-term investments which are expected to be invested in during the 
life of the swap. The anticipated investments include U.S. Treasury 
securities, U.S. government agency securities, commercial paper and corporate 
debt obligations.  Swaps are used to extend the maturity of the investment 
portfolio. 

For the years ended December 31, 1996 and 1995, the weighted average rate 
received on swaps was 6.71% and 7.29%, respectively, and the weighted average 
rate paid on swaps was 5.68% and 6.56%, respectively. Net interest income 
(loss) from swaps, including amortization of net losses on terminated swaps, 
totaled $2.5 million in 1996 and ($0.7) million in 1995.

During 1995, to reduce the average effective maturity of its portfolio, the 
Company terminated certain swap agreements prior to maturity and is amortizing 
the realized gains and losses over the original contractual term of the swaps 
as a reduction to interest income. At December 31, 1996, net losses of $0.7 
million remained unamortized; $0.5 million will be recognized in 1997 and $0.2 
million will be recognized in 1998.

Equity Collar Instruments:  To hedge against fluctuations in the market value  
of a portion of the marketable equity portfolio, the Company has entered into 
costless collar instruments, a form of equity collar instrument, that expire 
in 1998 and 1999 and will require settlement in equity securities or cash.  A 
costless collar instrument is a purchased put option and a written call option 
on a specific equity security such that the cost of the purchased put and the 
proceeds of the written call offset each other; therefore, there is no initial 
cost or cash outflow for these instruments.  The fair value of the purchased 
puts and the written calls were determined based on quoted market prices at 
year end.  At December 31, 1996, the notional amount of the put and call 
options were $17.2 million and $27.5 million, respectively.





The tables below outline specific information for the swaps outstanding at 
December 31, 1996 and 1995. The fair value is based on market prices of similar 
agreements. Dollars are in millions. 

<TABLE>
<CAPTION>
                         Interest Rate Swaps            Short-term Investments
                      ---------------------------     --------------------------------
                               Fixed                                        Average
                               Rates    Variable                           Effective
                      Notional To Be    Rates To       Carrying  Average   Interest
December 31, 1996:    Amounts  Received Be Paid*        Value   Maturity**   Rate
- -------------------------------------------------------------------------------------
<S>                   <C>      <C>      <C>           <C>         <C>         <C>
Swaps matched
  to investments
  to meet maturity 
  target comparable
  to outstanding debt                    3- or 6-
  [Maturing on:                 7.68%-    month
   1/2/02]              $150    7.71%     LIBOR        $150         13 days    5.66%

Swaps matched to
  other investments
  to meet specific
  maturity targets                       3- or 6-
  [Ending dates:                 4.97%-   month
   10/27/97-9/20/99]      60     7.20%    LIBOR          60         32 days    5.47%

Other short-term 
  investments              -                            206    
                      --------                       --------
    Total               $210                           $416   
                      ========                       ========


December 31, 1995:
- ------------------

Swaps matched
  to investments
  to meet maturity 
  target comparable
  to outstanding debt                    3- or 6-
  [Maturing on:                 7.68%-    month
   1/2/02]              $150    7.71%     LIBOR         $150     118 days    5.52%

Swaps matched to
  other investments
  to meet specific
  maturity targets                       3- or 6-
  [Ending dates:                6.09%-    month
   8/12/97 - 9/20/99]     80    7.20%     LIBOR           80      93 days    5.85%

Other short-term 
  investments              -                             373                    
                      --------                        --------
    Total               $230                            $603                  
                      ========                        ========
<FN>

*  3- and 6-month LIBOR rates are reset every 3 or 6 months.  At December 31, 
1996, the 3-month LIBOR rate and the 6-month LIBOR rate were 5.6%.  At December 
31, 1995, the 3-month LIBOR rate was 5.6% and the 6-month LIBOR rate was 5.5%.

** Average maturity reflects either the maturity date or, for a floating 
investment, the next reset date.
</TABLE>
Financial Instruments Held for Trading Purposes:  As part of its overall 
investment strategy, the Company has contracted with two external money 
managers to manage part of its investment portfolio.  One portfolio, which had 
a carrying value of $37.2 million at December 31, 1996, and $34.9 million at 
December 31, 1995, consisted of primarily non-dollar denominated investments.  
To hedge the non-dollar denominated investments, the money manager enters into 
forward contracts.  The fair value at December 31, 1996 and 1995, of the 
forward contracts totaled $0.8 million and $0.1 million, respectively.  The 
average fair value during 1996 and 1995 totaled $0.3 million and $0.1 million, 
respectively.  Net realized and unrealized trading gains on the portfolio 
totaled approximately $2.4 million in 1996 and $3.8 million in 1995, and are 
included in interest income.  Counterparties have strong credit ratings which 
minimize the risk of non-performance from the counterparties.

Summary of Fair Values:  The table below summarizes the carrying value and fair 
value at December 31, 1996 and 1995, of the Company's financial instruments. 
The fair value of the long-term debt was estimated based on the quoted market 
price at year end.


                                            1996                  1995
                                     ------------------  ---------------------
                                      Carrying     Fair     Carrying    Fair
Financial Instrument                    Value     Value       Value    Value
- ------------------------------------------------------------------------------
                                                 (thousands)
Assets:
Investment securities
 (including accrued interest 
   and traded forward contracts)     $ 951,816  $ 951,588  $959,771   $959,834
Purchased foreign exchange put 
  options                                4,616      7,273     2,345      6,300
Outstanding interest rate swaps (net)    2,122     11,555     7,194     23,940

Liabilities:
Short-term and long-term debt          150,000    139,500   150,358    147,750
Equity collars                           1,222      4,892         -          -
Foreign exchange forward contracts         138        138       237        237



OTHER ACCRUED LIABILITIES

Other accrued liabilities at December 31 are as follows (thousands):


                                                     1996                1995
- ------------------------------------------------------------------------------
Accrued compensation                              $ 42,716            $ 36,945
Accrued clinical and other studies                  39,981              27,290
Accrued royalties                                   25,098              23,159
Accrued marketing and promotion costs               11,889              18,863
Income taxes payable                                18,530              14,329
Other                                               56,328              67,012
                                                 -----------------------------
  Total other accrued liabilities                 $194,542            $187,598
                                                 =============================







LONG-TERM DEBT

The Company's long-term debt as of December 31, 1996 and 1995 consisted of 
$150.0 million of convertible subordinated debentures, with interest payable 
at 5%, due in 2002.  The debentures are convertible at the option of the 
holder into shares of the Company's special common stock.  Upon conversion, 
the holder receives, for each $74 in principal amount of debenture converted, 
one-half share of the Company's special common stock and $18 in cash. The $18 
in cash is reimbursed by Roche to the Company.  Generally, the Company may 
redeem the debentures until maturity.

LEASES, COMMITMENTS AND CONTINGENCIES

Future minimum lease payments under operating leases at December 31, 1996 are 
as follows (thousands):


                                                         
  1997      1998       1999       2000        2001    Thereafter      Total
- ------------------------------------------------------------------------------
$7,563     3,942      5,400      5,121       4,791      9,155        $35,972


The Company leases various real property under operating leases that generally 
require the Company to pay taxes, insurance and maintenance.  Rent expense was 
approximately $11.7 million, $9.5 million and $6.5 million for the years 1996, 
1995 and 1994, respectively.  Sublease income was not material in any of the 
three years presented.

Under three of the lease agreements, the Company has an option to purchase the 
properties at an amount that does not constitute a bargain.  Alternatively, 
the Company can cause the property to be sold to a third party.  The Company 
is contingently liable, under residual value guarantees, for approximately 
$166.0 million.  The Company also is required to maintain certain financial 
ratios and is limited to the amount of additional debt it can assume.

Pursuant to its research and development collaboration agreement entered into 
with Scios Inc. (Scios) in 1995, the Company established a line of credit for 
$30 million that Scios may draw down at Scios' discretion through 2002. This 
commitment is supported through December 31, 1997, by a bank letter of credit 
under which Scios may draw up to $30 million directly from the bank, with 
immediate repayment of the funds due to the bank by the Company. Amounts drawn 
by Scios under the bank letter of credit or directly from the Company are 
repayable in the form of cash or Scios common stock (at the average market 
price over the thirty day period before the date of repayment) at Scios' 
option any time through December 30, 2002. Interest on amounts borrowed by 
Scios accrue to the Company at the prime rate of interest. At December 31, 
1996 and 1995, no amounts were drawn.

In addition, the Company has entered into research collaborations with 
companies whereby potential future payments may be due to selective 
collaborative partners if the partners achieve certain benchmarks as defined 
in the collaborative agreements.  The Company may also, from time to time, 
lend additional funds to these companies, subject to approval.

The Company is a party to various legal proceedings including patent 
infringement cases involving human growth hormone products and Activase; 
product liability cases involving Activase and growth hormone products; and 
class action lawsuits regarding Protropin.  In addition, in 1995 the Company 
received and responded to grand jury document subpoenas from the United States 
District Court for the Northern District of California for documents relating 
to the Company's clinical, sales and marketing activities associated with 
human growth hormone.  In February 1997, the Company received another grand 
jury document subpoena from the same court related to the same subject matter. 
Based upon the nature of the claims made and the investigations completed to 
date by the Company and its counsel, the Company believes the outcome of these 
actions will not have a material adverse effect on the financial position, 
results of operations or cash flows of the Company.  However, were an 
unfavorable ruling to occur in any quarterly period, there exists the 
possibility of a material impact on the net income of that period.

RELATIONSHIP WITH ROCHE HOLDINGS, INC.

On October 25, 1995, the Company and Roche entered into a new agreement (the 
Agreement).  Each share of the Company's common stock not held by Roche or its 
affiliates on that date automatically converted to one share of callable 
putable common stock (special common stock).  The Agreement extends until June 
30, 1999, Roche's option to cause the Company to redeem (call) the outstanding 
special common stock of the Company at predetermined prices. Should the call 
be exercised, Roche will concurrently purchase from the Company a like number 
of common shares for a price equal to the Company's cost to redeem the special 
common stock.  During the quarter beginning January 1, 1997, the call price is 
$69.25 per share; it increases by $1.25 in the following quarter, then 
increases by $1.50 per share each quarter through the end of the option period 
on June 30, 1999, on which date the price is $82.50 per share.  If Roche does 
not cause the redemption as of June 30, 1999, the Company's stockholders will 
have the option (the put) to cause the Company to redeem none, some, or all of 
their shares of special common stock at $60.00 per share (and Roche will 
concurrently provide the necessary redemption funds to the Company by 
purchasing a like number of shares of common stock at $60.00 per share) within 
thirty business days commencing July 1, 1999.  Roche Holding Ltd, a Swiss 
corporation, has guaranteed Roche's obligation under the put.

In conjunction with the Agreement, HLR was granted an option for ten years for 
licenses to use and sell certain of the Company's products in non-U.S. 
markets.  As a general matter, such option for a Genentech product must be 
exercised at, or prior to if the Company mutually agrees, the conclusion of 
phase II clinical trials for each product.  In general, for each product for 
which HLR exercises its option, the Company and HLR will share equally all 
development expenses incurred by the Company through the option exercise date 
and prospectively with respect to the development of the product in the United 
States.  HLR will pay all non-U.S. development expenses.  At the Company's 
election, and with HLR's consent, HLR may reimburse the Company for HLR's 
share of development costs incurred prior to HLR's option exercise date, 
either by payment of such costs at the time of the option exercise or by 
making payments prospectively until HLR's share has been fully reimbursed to 
the Company.

In general, HLR pays a royalty of 12.5% until a product reaches $100 million 
in aggregate sales outside of the U.S., at which time the royalty rate 
increases to 15%. In addition, HLR has exclusive rights to, and pays the 
Company 20% royalties on, Canadian sales of the Company's existing products 
and European sales of Pulmozyme.  Consequently, in the fourth quarter of 1995, 
the Company transferred to HLR the rights to its Canadian product sales and 
European sales of Pulmozyme, and commenced recording royalty revenue from HLR 
on such sales.  The Company supplies its products to HLR, and has agreed to 
supply products for which HLR has exercised its option, for sales outside of 
the U.S. at cost plus 20%.

Under the Agreement, independent of its right to cause the Company to redeem 
the special common stock, Roche may increase its ownership of the Company up 
to 79.9% by making purchases on the open market.  Roche holds approximately 
66.0% of the outstanding common equity of the Company as of December 31, 1996.  
In January and February 1997, Roche purchased additional shares of the 
Company's common equity increasing Roche's holdings to 68.0%.



RELATED PARTY TRANSACTIONS 

The Company has transactions with Roche, HLR (a wholly owned subsidiary of 
Roche, with two officers on the Company's Board of Directors), and its 
affiliates in the ordinary course of business.  In 1996, HLR exercised its 
option under the Agreement with respect to the development of three projects - 
IDEC-C2B8, insulin-like growth factor (IGF-1) and nerve growth factor (NGF). 
The Company recorded non-recurring contract revenues of $58.2 million relating 
to the option exercises.  Other contract revenue from HLR, including 
reimbursement for ongoing development expenses after the option exercise date 
for the three projects, totaled $37.1 million in 1996, $13.4 million in 1995 
and $17.1 million in 1994.  All other revenue from Roche, HLR and their 
affiliates, principally royalties under previous product licensing agreements, 
and royalties and product sales under the Agreement, totaled $39.5 million in 
1996, $14.3 million in 1995 and $8.5 million in 1994. During the three years, 
the Company has collaborated with HLR on other projects.

CAPITAL STOCK

Common Stock, Special Common Stock and Redeemable Common Stock

After the close of business on June 30, 1995, each share of the Company's 
redeemable common stock automatically converted to one share of Genentech 
common stock, in accordance with the terms of the redeemable common stock put 
in place at the time of its issuance in 1990 and as described in Genentech's 
Certificate of Incorporation.  On October 25, 1995, pursuant to the Agreement 
with Roche, each share of the Company's common stock not held by Roche or its 
affiliates automatically converted to one share of callable putable common 
stock (special common stock).  See the "Relationship with Roche Holdings, 
Inc." note above for a discussion of these transactions.

Stock Award Plans

The Company has stock option plans adopted in 1996, 1994, 1990 and 1984, which 
variously allow for the granting of non-qualified stock options, incentive 
stock options and stock appreciation rights to employees, and the granting of 
non-qualified stock options to directors and consultants of the Company.  
Generally, non-qualified options have a maximum term of 20 years and incentive 
options have a maximum term of 10 years.  In general, options vest in 
increments over four years from the date of grant, although the Company may 
grant options with different vesting terms from time to time.  No stock 
appreciation rights have been granted to date.  

The Company adopted the 1991 Employee Stock Plan (1991 Plan) on December 4, 
1990, and amended it during 1993 and 1995. All full-time employees of the 
Company are eligible to participate in the 1991 Plan. Of the 3,800,000 shares 
of special common stock reserved for issuance under the 1991 Plan, 2,865,196 
shares have been issued as of December 31, 1996.  During 1996, 2,487 of the 
eligible employees participated in the 1991 Plan.

The Company has elected to continue to follow APB 25 for accounting for its 
employee stock options because the alternative fair value method of accounting 
prescribed by FAS 123 requires the use of option valuation models that were 
not developed for use in valuing employee stock options. Under APB 25, no 
compensation expense is recognized because the exercise price of the Company's 
employee stock options equals the market price of the underlying stock on the 
date of grant.  

Pro forma information regarding net income and earnings per share in 1996 and 
1995 has been determined as if the Company had accounted for its employee 
stock options and employee stock plan under the fair value method prescribed 
by FAS 123.  The resulting effect on pro forma net income and earnings per 
share disclosed for 1996 and 1995 is not likely to be representative of the 
effects on net income and earnings per share on a pro forma basis in future 
years, because 1995 and 1996 pro forma results include the impact of only one 
and two years, respectively, of grants and related vesting, while subsequent 
years will include additional years of grants and vesting.  The fair value of 
options was estimated at the date of grant using a Black-Scholes option 
valuation model with the following weighted average assumptions:  risk-free 
interest rates of 5.8% for 1996 and 6.0% for 1995; dividend yields of 0%; 
volatility factors of the expected market price of the Company's common stock 
of 6.2%; and a weighted-average expected life of the option of 5.0 years.  
Grants under the employee stock plan terminate with each quarterly stock 
purchase.

The Black-Scholes option valuation model was developed for use in estimating 
the fair value of traded options which have no vesting restrictions and are 
fully transferable.  In addition, option valuation models require the input of 
highly subjective assumptions including the expected stock price volatility.  
Because the Company's employee stock options have characteristics 
significantly different from those of traded options, and because changes in 
the subjective input assumptions can materially affect the fair value 
estimate, in management's opinion the existing models do not necessarily 
provide a reliable single measure of the fair value of its employee stock 
options. 

For purposes of pro forma disclosures, the estimated fair value of options is 
amortized to pro forma expense over the options' vesting period. Pro forma 
information for the years ending December 31 follows (in thousands, except per 
share amounts):

                                                  1996            1995
                                                  ----            ----   
Net income - as reported                      $ 118,348       $ 146,432  
Net income - pro forma                          104,358         142,370  
Earnings per share - as reported                   0.96            1.21  
Earnings per share - pro forma                     0.84            1.18  


A summary of the Company's stock option activity and related information were 
as follows:

                                                Shares        Weighted Average
                                                                    Price   
                                              -----------     ----------------
Options outstanding at December 31, 1993       12,439,727         $  27.38
Grants                                          5,137,055            50.19
Exercises                                      (1,400,223)           23.53
Cancellations                                    (195,752)           36.89
Options outstanding at December 31, 1994       15,980,807            34.93
Grants                                          1,303,800            48.52
Exercises                                      (1,472,759)           24.60
Cancellations                                    (602,774)           42.59
                                              ------------
Options outstanding at December 31, 1995       15,209,074            36.80
Grants                                          6,761,545            53.99
Exercises                                      (1,624,541)           29.39
Cancellations                                    (743,569)           48.93
                                              ------------
Options outstanding at December 31, 1996       19,602,509            42.89
                                              ============







The following table summarizes information concerning currently outstanding and 
exercisable options:


                          Options Outstanding             Options Exercisable
                   -----------------------------------   ----------------------
                                 Weighted
                                  Average     Weighted                Weighted
                                 Remaining    Average                 Average
Range of             Number     Contractual   Exercise     Number     Exercise
Exercise Prices    Outstanding     Life        Price     Exercisable    Price
- -----------------  -----------  -----------   --------   -----------  ---------

$14.080 - $20.625    1,278,761      2.83       $17.01      1,278,361   $17.01
$21.375 - $31.000    4,181,212     12.77        26.37      4,114,332    26.37
$32.125 - $48.125    2,964,663     16.74        41.68      2,126,573    39.33
$48.250 - $54.250   11,177,873     13.42        52.45        952,284    50.45
                   -----------                           -----------
                    19,602,509     13.09        42.93      8,471,550    30.91
                   ===========                           ===========
     


Using the Black-Scholes option valuation model, the weighted average fair value 
of options granted in 1996 and 1995 was $13.36 and $12.27, respectively.  
Shares of special common stock available for future grants under all stock 
option plans were 4,469,574 at December 31, 1996.

Warrants

All previously outstanding warrants to purchase the Company's special common 
stock were exercised or expired as of July 31, 1996.  As of December 31, 1995, 
121,445 shares subject to exercisable warrants were outstanding, with a price 
range of $27.57 to $28.26.  113,093 shares were exercised through July 31, 
1996, at a price range of $27.57 to $28.26, and 8,352 shares expired 
unexercised.

QUASI-REORGANIZATION

On October 1, 1987, the Company eliminated its accumulated deficit through an 
accounting reorganization of its stockholders' equity accounts (a quasi-
reorganization) that did not involve any revaluation of assets or liabilities. 
An accumulated deficit of $329.5 million was eliminated by a transfer from 
additional paid-in capital in an amount equal to the accumulated deficit.

The Company has been recording, in income, the recognition of operating loss 
and tax credit carryforward items arising prior to the quasi-reorganization 
due to the Company's adoption of its quasi-reorganization in the context of 
the accounting and quasi-reorganization literature existing at the date the 
quasi-reorganization was effected. If the provisions of the subsequently 
issued Staff Accounting Bulletin 86 (SAB 86) had been applied, net income in 
1995 would have been reduced by $11.8 million or $.10 per share, and 1994 net 
income would have been reduced by $39.7 million or $.33 per share, because SAB 
86 would require that the tax benefits of prior operating loss and tax credit 
carryforwards be reported as a direct addition to additional paid-in capital 
rather than being recorded in the income statement. The Securities and 
Exchange Commission staff has indicated that it would not object to the 
Company's accounting for such tax benefits.  As of June 30, 1995, the 
operating loss and tax credit carryforwards arising prior to the quasi-
reorganization had been fully utilized, therefore there was no impact on 
earnings in 1996.



REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

The Board of Directors and Stockholders of Genentech, Inc.

We have audited the accompanying consolidated balance sheets of Genentech, 
Inc. as of December 31, 1996 and 1995, and the related consolidated statements 
of income, stockholders' equity, and cash flows for each of the three years in 
the period ended December 31, 1996. These financial statements are the 
responsibility of the Company's management. Our responsibility is to express 
an opinion on these financial statements based on our audits.

We conducted our audits in accordance with generally accepted auditing 
standards. Those standards require that we plan and perform the audit to 
obtain reasonable assurance about whether the financial statements are free of 
material misstatement. An audit includes examining, on a test basis, evidence 
supporting the amounts and disclosures in the financial statements. An audit 
also includes assessing the accounting principles used and significant 
estimates made by management, as well as evaluating the overall financial 
statement presentation. We believe that our audits provide a reasonable basis 
for our opinion.

In our opinion, the financial statements referred to above present fairly, in 
all material respects, the consolidated financial position of Genentech, Inc. 
at December 31, 1996 and 1995, and the consolidated results of its operations 
and its cash flows for each of the three years in the period ended December 
31, 1996, in conformity with generally accepted accounting principles.


                                                            Ernst & Young LLP


San Jose, California
January 17, 1997































QUARTERLY FINANCIAL DATA (UNAUDITED)
(thousands, except per share amounts)


                                              1996 Quarter Ended
                               -----------------------------------------------

                               December 31   September 30   June 30   March 31
- ------------------------------------------------------------------------------

Total revenues                   $230,325    $251,707      $243,762   $242,884
Product sales                     139,724     142,463       148,305    152,337
Gross margin from product sales   113,065     117,627       121,152    126,458
Net income                          7,470      50,942        21,719     38,217
Net income per share                  .06         .41           .18        .31



                                              1995 Quarter Ended
                               -----------------------------------------------

                               December 31   September 30   June 30   March 31
- ------------------------------------------------------------------------------

Total revenues                   $221,914    $223,911      $233,053   $238,967
Product sales                     153,482     158,478       161,236    162,067
Gross margin from product sales   130,983     134,109       136,924    135,317
Net income                         25,636      40,229        37,163     43,404
Net income per share                  .21         .33           .31        .36


Total revenues were higher in the first three quarters of 1996 compared to the 
fourth quarter due primarily to contract revenue from HLR for the exercises of 
its options under the Agreement (see the "Related Party Transactions" note in 
the "Notes to Consolidated Financial Statements" for more information) in each 
of the first three quarters.  Net income was lower in the fourth quarter due 
to lower revenues and higher expenses, primarily research and development.



























<TABLE>
<CAPTION>
11-YEAR FINANCIAL SUMMARY (UNAUDITED)
(millions, except per share and employee data)

                                               1996    1995     1994     1993     1992
- ---------------------------------------------------------------------------------------
<S>                                        <C>      <C>      <C>      <C>      <C>
Total revenues                              $ 968.6  $ 917.8  $ 795.4  $ 649.7  $ 544.3
  Product sales                               582.8    635.3    601.0    457.4    391.0
  Royalties                                   214.7    190.8    126.0    112.9     91.7
  Contract & other                            107.0     31.2     25.6     37.9     16.7
  Interest                                     64.1     60.5     42.8     41.5     44.9
                                         ----------------------------------------------

Total costs and expenses                    $ 820.7  $ 745.6  $ 665.8  $ 590.8  $ 522.3
  Cost of sales                               104.5     97.9     95.8     70.5     66.8
  Research & development                      471.1    363.0    314.3    299.4    278.6
  Marketing, general & administrative         240.1    251.7    248.6    214.4    172.5
  Special charge                                  -     25.0(1)     -        -        -
  Interest                                      5.0      8.0      7.1      6.5      4.4
                                         ----------------------------------------------
Income data
  Income (loss) before taxes                $ 147.9  $ 172.2  $ 129.6   $ 58.9   $ 21.9
  Income tax provision                         29.6     25.8      5.2        -      1.1
  Net income (loss)                           118.3    146.4    124.4     58.9     20.8
  Net income (loss) per share                  0.96     1.21     1.04     0.50     0.18
                                         ----------------------------------------------

Selected balance sheet data
  Cash, short-term investments
    & marketable securities                $1,159.1 $1,096.8  $ 920.9  $ 719.8  $ 646.9
  Accounts receivable                         197.6    172.2    146.3    130.5     93.9
  Inventories                                  91.9     93.6    103.2     84.7     65.3
  Property, plant & equipment, net            586.2    503.7    485.3    456.7    432.5
  Other long-term assets                      149.2    105.5     61.0     64.1     37.1
  Total assets                              2,226.4  2,011.0  1,745.1  1,468.8  1,305.1
  Total current liabilities                   250.0    233.4    220.5    190.7    133.5
  Long-term debt                              150.0    150.0    150.4    151.2    152.0
  Total liabilities                           425.3    408.9    396.3    352.0    297.8
  Total stockholders' equity                1,801.1  1,602.0  1,348.8  1,116.8  1,007.3
                                         ----------------------------------------------

Other data
  Depreciation and amortization expense     $  62.1  $  58.4  $  53.5  $  44.0  $  52.2
  Capital expenditures                        141.8     70.2     82.8     87.5    126.0
                                         ----------------------------------------------

Share information
  Shares used to compute EPS                  123.7    121.2    119.5    117.1    114.0
  Actual year-end                             121.4    119.3    117.2    114.8    112.9
                                         ----------------------------------------------

Per share data
  Market price:       High                  $ 55.38  $ 53.00* $ 53.50  $ 50.50  $ 39.50

                      Low                   $ 51.38  $ 44.50* $ 41.75  $ 31.25  $ 25.88

  Book value                                $ 14.84  $ 13.43  $ 11.50  $  9.73  $  8.92
                                         ----------------------------------------------

Number of employees                           3,071    2,842    2,738    2,510    2,331
                                         ----------------------------------------------

<FN>
The Company has paid no dividends.
The Financial Summary above reflects adoption of FAS 121 in 1996, FAS 115 in 1994, FAS 
109 in 1992 and FAS 96 in 1988.
All share and per share amounts reflect a two-for-one split in 1986 and a two-for-one 
split in 1987.
*Special common stock began trading October 26, 1995.  On October 25, 1995, pursuant to 
the new Agreement with Roche, each share of the Company's common stock not held by 
Roche or its affiliates automatically converted to one share of special common stock.
**Redeemable common stock began trading September 10, 1990; prior to that date
all shares were common stock.  Pursuant to the merger agreement with Roche, all
shareholders as of effective date September 7, 1990, received for each common
share owned, $18 in cash from Roche and one-half share of newly issued
redeemable common stock from the Company.
(1) Charges related to 1995 merger and new Agreement with Roche ($21 million) and 
      resignation of the Company's former CEO ($4 million).
(2) Charges primarily related to 1990 Roche merger.
(3) Primarily inventory-related charge.
(4) Charge for purchase of in-process R&D.

</TABLE>













































     1991       1990       1989       1988       1987       1986    
- --------------------------------------------------------------------

 $  515.9    $ 476.1    $ 400.5    $ 334.8    $ 230.5    $ 134.0    
    383.3      367.2      319.1      262.5      141.4       43.6    
     63.4       47.6       36.7       26.7       20.1       12.9    
     20.4       31.9       27.5       33.5       57.1       70.9    
     48.8       29.4       17.2       12.1       11.9        6.6    
- --------------------------------------------------------------------

 $  469.8    $ 572.7    $ 352.9    $ 311.7    $ 186.6    $ 484.6    
     68.4       68.3       60.6       46.9       23.8       10.8    
    221.3      173.1      156.9      132.7       96.5       79.8    
    175.3      158.1      127.9      101.9       59.5       27.3    
        -      167.7(2)       -       23.3(3)       -      366.7(4) 
      4.8        5.5        7.5        6.9        6.8          -    
- --------------------------------------------------------------------

 $   46.1    $ (96.6)    $ 47.6     $ 23.1     $ 43.9   $ (350.6)   
      1.8        1.5        3.6        2.5        1.7        2.4    
     44.3      (98.0)      44.0       20.6       42.2     (353.0)   
     0.39      (1.05)      0.51       0.24       0.50      (5.10)   
- --------------------------------------------------------------------

 $  711.4    $ 691.3    $ 205.0    $ 152.5    $ 158.3     $ 84.3    
     69.0       58.8       66.8       63.9       92.2       24.5    
     56.2       39.6       49.3       63.4       58.0       14.7    
    342.5      300.2      299.1      289.4      195.7      133.1    
     42.7       61.7       85.0       89.7      108.7      114.9    
  1,231.4    1,157.7      711.2      662.9      619.0      376.0    
    118.6      101.4       75.9       95.4       82.8       37.8    
    152.9      153.5      154.4      155.3      168.1       31.6    
    281.7      264.5      242.2      263.6      263.6       83.3    
    949.7      893.2      469.0      399.3      355.4      292.6    
- --------------------------------------------------------------------

 $   46.9     $ 47.6     $ 44.6     $ 38.3     $ 23.5     $  8.1    
     71.3       36.0       37.2      110.9       65.3       46.3    
- --------------------------------------------------------------------

    112.5       93.0       86.0       84.5       84.4       69.3    
    111.3      110.6       84.3       82.9       78.7       67.0    
- --------------------------------------------------------------------

 $  36.25    $ 30.88    $ 23.38    $ 47.50    $ 64.75    $ 49.38   
             $ 27.50**
 $  20.75    $ 20.13    $ 16.00    $ 14.38    $ 28.00    $ 16.44   
             $ 21.75**
 $   8.53    $  8.08    $  5.56    $  4.82    $  4.52    $  4.37   
- --------------------------------------------------------------------

    2,202      1,923      1,790      1,744      1,465      1,168    
- --------------------------------------------------------------------









COMMON STOCK, SPECIAL COMMON STOCK AND REDEEMABLE COMMON STOCK INFORMATION

Stock Trading Symbol   GNE

Stock Exchange Listings

The Company's callable putable common stock (special common stock) has traded 
on the New York Stock Exchange and the Pacific Stock Exchange under the symbol 
GNE since October 26, 1995.  On October 25, 1995, the Company's non-Roche 
stockholders approved a new agreement (the Agreement) with Roche Holdings, 
Inc. (Roche).  Pursuant to the Agreement, each share of the Company's common 
stock not held by Roche or its affiliates automatically converted to one share 
of special common stock.  From July 3, 1995 through October 25, 1995, the 
Company's common stock was traded under the symbol GNE.  After the close of 
business on June 30, 1995, each share of the Company's redeemable common stock 
automatically converted to one share of the Company's common stock.  The 
conversion was in accordance with the terms of the redeemable common stock put 
in place at the time of its issuance on September 7, 1990, when the Company's 
merger with a wholly owned subsidiary of Roche was consummated.  The 
redeemable common stock of the Company traded under the symbol GNE from 
September 10, 1990 to June 30, 1995. The Company's common stock was traded on 
the New York Stock Exchange under the symbol GNE from March 2, 1988, until 
September 7, 1990, and on the Pacific Stock Exchange under the symbol GNE from 
April 12, 1988, until September 7, 1990. The Company's common stock was 
previously traded in the NASDAQ National Market System under the symbol GENE. 
No dividends have been paid on the common stock, special common stock or 
redeemable common stock. The Company currently intends to retain all future 
income for use in the operation of its business and, therefore, does not 
anticipate paying any cash dividends in the foreseeable future.  See the 
"Relationship with Roche Holdings, Inc." note in the "Notes to  Consolidated 
Financial Statements" for a further description of the Agreement with Roche. 

Special Common Stockholders

As of December 31, 1996, there were approximately 16,748 stockholders of 
record of the Company's special common stock.


Stock Prices                Special Common/Redeemable Common/Common Stock
                                  1996                       1995
- --------------------------------------------------------------------------

                             High        Low         High          Low
                         -------------------------------------------------

4th Quarter               $ 54 3/8     $ 52 3/4    $ 53          $ 47 7/8
3rd Quarter                 53 1/4       51 3/8      49 1/4        46 5/8
2nd Quarter                 53 3/8       51 7/8      52            46 3/8
1st Quarter                 55 3/8       52 1/2      51            44 1/2









  






                                                                 Exhibit 23.1


CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in this Annual Report (Form 10-K) 
of Genentech, Inc. of our report dated January 17, 1997, included in the 1996 
Annual Report to Stockholders of Genentech, Inc.

Our audits also included the financial statement schedule of Genentech, Inc. 
listed in Item 14(a).  This schedule is the responsibility of the Company's 
management.  Our responsibility is to express an opinion based on our audits.  
In our opinion, the financial statement schedule referred to above, when 
considered in relation to the basic financial statements taken as a whole, 
presents fairly in all material respects the information set forth therein.

We also consent to the incorporation by reference in the Registration 
Statements pertaining to the 1991 Employee Stock Plan, the 1996 Stock 
Option/Stock Incentive Plan, the 1994 Stock Option Plan, the 1990 Stock 
Option/Stock Incentive Plan, the 1984 Incentive Stock Option Plan and the 1984 
Non-Qualified Stock Option Plan, the shares issuable to certain convertible 
subordinated debenture holders, the Genentech, Inc. Tax Reduction Investment 
Plan and in the related Prospectuses of our report dated January 17, 1997, 
with respect to the consolidated financial statements incorporated herein by 
reference, and our report included in the preceding paragraph with respect to 
the financial statement schedule included in this Annual Report (Form 10-K) 
for the year ended December 31, 1996.


                                                       Ernst & Young LLP




San Jose, California
March 21, 1997



<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONSOLIDATED BALANCE SHEETS, CONSOLIDATED STATEMENTS OF INCOME AND CONSOLIDATED
STATEMENTS OF CASH FLOWS INCLUDED IN THE COMPANY'S FORM 10-K FOR THE YEAR ENDED
DECEMBER 31, 1996, AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH
FINANCIAL STATEMENTS AND THE NOTES THERETO.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-END>                               DEC-31-1996
<CASH>                                         207,264
<SECURITIES>                                   951,816
<RECEIVABLES>                                  205,481
<ALLOWANCES>                                     7,869
<INVENTORY>                                     91,943
<CURRENT-ASSETS>                               955,084
<PP&E>                                         906,267
<DEPRECIATION>                                 320,100
<TOTAL-ASSETS>                               2,226,372
<CURRENT-LIABILITIES>                          249,951
<BONDS>                                        150,000
                                0
                                          0
<COMMON>                                         2,428
<OTHER-SE>                                   1,798,631
<TOTAL-LIABILITY-AND-EQUITY>                 2,226,372
<SALES>                                        582,829
<TOTAL-REVENUES>                               968,678
<CGS>                                          104,527
<TOTAL-COSTS>                                  104,527
<OTHER-EXPENSES>                               471,143
<LOSS-PROVISION>                                 9,887   
<INTEREST-EXPENSE>                               5,010 
<INCOME-PRETAX>                                147,935
<INCOME-TAX>                                    29,587
<INCOME-CONTINUING>                            118,348
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   118,348
<EPS-PRIMARY>                                     0.96
<EPS-DILUTED>                                        0
        

</TABLE>

                               GENENTECH, INC.

           1984 INCENTIVE STOCK OPTION PLAN, AS AMENDED AND RESTATED
                         (Effective October 16, 1996)

1.  PURPOSE

  (a) The purpose of the Plan is to provide a means by which selected key 
employees of GENENTECH, INC. (the "Company") and its affiliates, as defined in 
subparagraph 1(b), may be given an opportunity to purchase stock of the 
Company.

  (b) The word "affiliate" as used in the Plan means any parent corporation or 
subsidiary corporation of the Company, as those terms are defined in Sections 
424(e) and (f), respectively, of the Internal Revenue Code of 1986, as amended 
(the "Code").

  (c) The Company, by means of the Plan, seeks to retain the services of 
persons now holding key positions, to secure and retain the services of 
persons capable of filling such positions, and to provide incentives for such 
persons to exert maximum efforts for the success of the Company.

  (d) The Company intends that the options issued under the Plan be incentive 
stock options as that term is used in Section 422 of the Code.

2. ADMINISTRATION

  (a) The Plan shall be administered by the Board of Directors (the "Board") 
of the Company unless and until the Board relegates administration to a 
committee, as provided in subparagraph 2(c). Whether or not the Board has 
delegated administration, the Board shall have the final power to determine 
all questions of policy and expediency that may arise in the administration of 
the Plan.

  (b) The Board shall have the power, subject to, and within the limitations 
of, the express provisions of the Plan:

  (1) To determine from time to time which of the persons eligible under the 
Plan shall be granted options; when and how the option shall be granted; the 
provisions of each option granted (which need not be identical), including the 
time or times during the term of each option within which all or portions of 
such option may be exercised; and the number of shares for which an option 
shall be granted to each person.

  (2) To construe and interpret the Plan and options granted under it, and to 
establish, amend and revoke rules and regulations for its administration. The 
Board, in the exercise of this power, may correct any defect, omission or 
inconsistency in the Plan or in any option agreement, in a manner and to the 
extent it shall deem necessary or expedient to make the Plan fully effective.

  (3) To amend the Plan as provided in paragraph 10.

  (4) Generally, to exercise such powers and to perform such acts as the Board 
deems necessary or expedient to promote the best interests of the Company.

  (c) The Board may delegate administration of the Plan to a committee 
composed of not fewer than three (3) members of the Board.  If administration 
is delegated to a committee, the committee shall have, in connection with the 
administration of the Plan, the powers theretofore possessed by the Board, 
subject, however, to such resolutions, not inconsistent with the provisions of 
the Plan, as may be adopted from time to time by the Board. The Board may 
abolish the committee at any time and revest in the Board the administration 
of the Plan.


3.  SHARES SUBJECT TO THE PLAN

  (a) Subject to the provisions of paragraph 9 relating to adjustments upon 
changes in stock, the stock that may be sold pursuant to options granted under 
this Plan shall not exceed in the aggregate Fifteen Million Ninety Four 
Thousand Three Hundred and Ninety Seven (15,094,397) shares of the Company's 
common stock; provided, however, that such aggregate number of shares shall be 
reduced to reflect the number of shares of the Company's common stock which 
has been sold under, or may be sold pursuant to outstanding options granted 
under, the Company's 1984 Non-Qualified Stock Option Plan (the "Non-Qualified 
Plan") to the same extent as if such sales had been made or options had been 
granted pursuant to this Plan. As used in this Plan, the "Company's common 
stock" includes all series of common stock authorized by the Company's charter 
documents, including the Common Stock and Earnings Convertible Restricted 
Stock now authorized and any other series that may in the future be 
authorized. If any option granted under this Plan or the Non-Qualified Plan 
shall for any reason expire or otherwise terminate without having been 
exercised in full, the stock not purchased under such option shall again 
become available for this Plan and the Non-Qualified Plan.

  (b) For options granted after December 31, 1986, an option may be granted to 
an eligible person under the Plan only if the aggregate fair market value 
(determined at the time the option is granted) of the stock with respect to 
which incentive stock options are exercisable for the first time by such 
optionee during any calendar year under all such plans of the Company and its 
affiliates does not exceed one hundred thousand dollars ($100,000). Should it 
be determined that any option granted under the Plan exceeds such maximum, 
such option shall be considered a nonstatutory stock option to the extent, but 
only to the extent, of such excess.

  (c) Subject to the limitations contained elsewhere herein and to the 
provisions of paragraph 9 relating to adjustments upon changes in stock, the 
aggregate number of shares of stock that may be subject to options granted to 
all persons who are directors of the Company at the time such Options are 
granted shall not exceed four hundred thousand (400,000) shares of the 
Company's common stock, and no single director of the Company may be granted 
options to purchase more than two hundred thousand (200,000) shares of the 
Company's common stock.

4.  ELIGIBILITY

  (a) Options may be granted only to key employees (including officers) of the 
Company or its affiliates. A director of the Company shall not be eligible to 
be granted an option under the Plan unless such director is also a key 
employee (including an officer) of the Company or an affiliate of the Company.

  (b) A director shall in no event be eligible to be granted an option under 
the Plan unless and until such director is expressly declared eligible to 
participate in the Plan by action of the Board or the committee.

  (c) No person shall be eligible for the grant of an option under the Plan 
if, at the time of grant, such person owns (or is deemed to own pursuant to 
Section 424(d) of the Code) stock assessing more than ten percent (10%) of the 
total combined voting power of all classes of stock of the Company or of any 
of its affiliates unless the options price is at least one hundred ten percent 
(110%) of the fair market value of such stock at the date of grant and the 
term of the option does not exceed five (5) years from the date of grant.

5.  OPTION PROVISIONS

  Each option shall be in such form and shall contain such terms and 
conditions as the Board or the committee shall deem appropriate. The 
provisions of separate options need not be identical, but each option shall 
include (through incorporation of provisions hereof by reference in the option 
or otherwise) the substance of each of the following provisions:

  (a) The term of any option shall not be greater than ten (10) years from the 
date it was granted.

  (b) The exercise price of each option shall be not less than one hundred 
percent (100%) of the fair market value of the stock subject to the option on 
the date the option is granted.

  (c) The purchase price of stock acquired pursuant to an option shall be 
paid, as specified in the option, either (i) in cash at the time the option is 
exercised, or (ii) at the discretion of the Board or the committee, (A) by 
delivery to the Company of other shares of the Company's common stock, (B) 
according to a deferred payment or other arrangement (which may include, 
without limiting the generality of the foregoing, the use of other common 
stock of the Company) with the person to whom the option is granted or to whom 
the option is transferred pursuant to subparagraph 5(d), or (C) in any other 
form of legal consideration that may be acceptable to the Board or the 
committee in their discretion, either at the time of grant or exercise of the 
option.

  In the case of any deferred payment arrangement specified at the time of 
grant, an interest rate shall be stated which is not less than the rate then 
specified which will prevent any imputation of higher interest under Section 
483 of the Code.

  (d) An option shall not be transferable except by will or by the laws of 
descent and distribution, and shall be exercisable during the lifetime of the 
person to whom the option is granted only by such person.
  
  (e) The total number of shares of stock subject to an option may, but need 
not, be allotted in periodic installments (which may, but need not, be equal). 
From time to time during each of such installment periods, the option may be 
exercised with respect to some or all of the shares allotted to that period, 
and/or with respect to some or all of the shares allotted to any prior period 
as to which the option was not fully exercised. During the remainder of the 
term of the option (if its term extends beyond the end of the installment 
periods), the option may be exercised from time to time with respect to any 
shares then remaining subject to the option. The provisions of this 
subparagraph 5(e) are subject to any option provisions governing the minimum 
number of shares as to which an option may be exercised.

  (f) [RESERVED]

  (g) The Company may require any optionee, or any person to whom an option is 
transferred under subparagraph 5(d), as a condition of exercising any such 
option to make such representations, warranties and agreements as the Company 
may deem appropriate to assure that issuance of the Company's common stock 
upon exercise of such option is in compliance with then applicable federal and 
state securities laws.

  (h) An option shall terminate three (3) months after termination of the 
optionee's employment with the Company or an affiliate, unless (i) the 
termination of employment of the optionee is due to such person's permanent 
and total disability, within the meaning of Section 422(c)(6) of the Code, in 
which case the option may, but need not, provide that it may be exercised at 
any time within one (1) year following such termination of employment; or (ii) 
the optionee dies while in the employ of the Company or an affiliate, or 
within not more than three (3) months after termination of such employment, in 
which case the option may, but need not, provide that it may be exercised at 
any time within eighteen (18) months following the death of the optionee by 
the person or persons to whom the optionee's rights under such option pass by 
will or by the laws of descent and distribution; or (iii) the option by its 
terms specifies either (a) that it shall terminate sooner than three (3) 
months after termination of the optionee's employment, or (b) that it may be 
exercised more than three (3) months after termination of the optionee's 
employment with the Company or an affiliate. This subparagraph 5(h) shall not 
be construed to extend the term of any option or to permit anyone to exercise 
the option after expiration of its term, nor shall it be construed to increase 
the number of shares as to which any option is exercisable from the amount 
exercisable on the date of termination of the optionee's employment.

  (i) The option may, but need not, include a provision whereby the optionee 
may elect any time during the term of his or her employment with the Company 
or any affiliate to exercise the option as to any part or all of the shares 
subject to the option prior to the stated vesting data of the option or of any 
installment or installments specified in the option. Any shares so purchased 
from any unvested installment or option may be subject to a repurchase right 
in favor of the Company or to any other restriction the Board or the committee 
determines to be appropriate.

  (j) Options may be granted to directors of the Company only during the first 
month of each calendar quarter. Any option held by a director of the Company 
may only be exercised during any period of ten business days beginning on the 
third business day after a quarterly or annual summary statement of the 
Company's revenues and earnings appears on a wire service or in a newspaper of 
general circulation, or is otherwise made generally available to the public.

6.  COVENANTS OF THE COMPANY

  (a) During the terms of the options granted under the Plan, the Company 
shall keep available at all times the number of shares of stock required to 
satisfy such options.

  (b) The Company shall seek to obtain from each regulatory commission or 
agency having jurisdiction over the Plan such authority as may be required to 
issue and sell shares of stock upon exercise of the options granted under the 
Plan; provided, however, that this undertaking shall not require the Company 
to register under the Securities Act of 1933, as amended, either the Plan, any 
option granted under the Plan or any stock issued or issuable pursuant to any 
such option. If the Company is unable to obtain from any such regulatory 
commission or agency the authority which counsel for the Company deems 
necessary for the lawful issuance and sale of stock under the Plan, the 
Company shall be relieved from any liability for failure to issue and sell 
stock upon exercise of such options unless and until such authority is 
obtained.

7.  USE OF PROCEEDS FROM STOCK

  Proceeds from the sale of stock pursuant to options granted under the Plan 
shall constitute general funds of the Company.

8.  MISCELLANEOUS

  (a) The Board or the committee shall have the power to accelerate the time 
during which an option may be exercised or the time during which the option or 
any part thereof will vest pursuant to subparagraph 5(e), notwithstanding the 
provisions in the option stating the time during which it may be exercised or 
the time during which it will vest.

  (b) Neither an optionee nor any person to whom an option is transferred 
under subparagraph 5(d) shall be deemed to be the holder of, or to have any of 
the rights of a holder with respect to, any shares subject to such option 
unless and until such person has satisfied all requirements for exercise of 
the option pursuant to its terms.

9.  ADJUSTMENTS UPON CHANGES IN STOCK

  (a) If any change is made in the stock subject to the Plan, or subject to 
any option granted under the Plan (through merger, consolidation, 
reorganization, recapitalization, stock dividend, dividend in property other 
than cash, stock split, liquidating dividend, combination of shares, exchange 
of shares, change in corporate structure or otherwise), the Board shall make 
appropriate adjustments in the maximum number of shares subject to the Plan 
and the number of shares and price per share of stock subject to outstanding 
options.

  (b) In the event of a Change of Control (as defined in subparagraph 9(c)), 
then as to options which are not then exercisable, the time during which such 
options may be exercised shall be accelerated to the 60-day period from and 
after a Change of Control, unless, in the opinion of the Board, it is clearly 
in the best interests of the optionholders and the shareholders taken together 
that the Company or a surviving corporation (if the Change of Control results 
in the Company not surviving) assume any outstanding options or substitute 
similar options for those outstanding under the Plan, in which case the Board 
may take appropriate action to effect an assumption or substitution.

  (c) "Change of Control" shall mean any of the following events:

  (1) the acquisition by any person (including a group, within the meaning of 
Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as 
amended), other than the Company or any of its subsidiaries, of beneficial 
ownership (within the meaning of Rule 13d-3 promulgated under the Securities 
Exchange Act of 1934, as amended) of 50% or more of the combined voting power 
of the Company's then outstanding voting securities; or

  (2) approval by stockholders of the Company of a merger, consolidation, 
liquidation or dissolution of the Company or of the sale of all or 
substantially all of the Company's assets.

  (d) Notwithstanding any provision to the contrary set forth herein, the 
consummation of the merger contemplated by the Agreement and Plan of Merger 
dated as of May 23, 1995, among the Company, Roche Holdings, Inc. and HLR 
(U.S.) II, Inc. shall not be deemed to be a Change of Control under the Plan.

  (e) From and after October 25, 1995, all references herein to "shares", 
"stock", or "the Company's common stock" shall be deemed to be references to 
shares of Callable Putable Common Stock, par value $0.02 per share, of the 
Company ("Special Common Stock"), except for the references to the shares of 
Common Stock of the Company contained in subparagraph 9(g).

  (f) Notwithstanding any provision to the contrary set forth herein, in the 
event that the Special Common Stock is redeemed in accordance with Article 
THIRD, Section (c)(ii) of the Company's Certificate of Incorporation, any 
options granted under the Plan that are exercisable for Special Common Stock 
and that are outstanding on the date of redemption (whether or not such 
options are exercisable on such date) shall become exercisable for 
consideration of the same type and amount as the holders thereof would have 
received had they exercised such options prior to such date of redemption.

  (g) Notwithstanding any provision to the contrary set forth herein, in the 
event that the shares of Special Common Stock are converted into shares of 
Common Stock, par value $0.02 per share, of the Company ("Common Stock") 
pursuant to Article THIRD, Section (c)(vi) of the Company's Certificate of 
Incorporation, each option granted under the Plan which is outstanding on the 
Conversion Date as such term is defined in Article THIRD, Section (c)(vi) of 
the Company's Certificate of Incorporation) shall automatically be canceled, 
and the holder thereof shall receive, in exchange therefor, a substitute 
option to purchase, at a per share exercise price equal to the per share 
exercise price of such canceled option, the number of shares of Common Stock 
equal to the number of shares of Special Common Stock subject to such canceled 
option. Such substitute option shall be subject to the same terms and 
conditions as the option for which it is exchanged, including with respect to 
vesting (such that such substitute option vests at the same time as the option 
for which it is exchanged would have vested) and the conditions relating to 
the exercise of the option. From and after the Conversion Date, all references 
herein to "shares", "stock", or the "Company's Common Stock" which in 
accordance with subparagraph 9(e) are deemed to be references to shares of 
Special Common Stock, shall be deemed to be references to shares of Common 
Stock.

10.  AMENDMENT OF THE PLAN

  (a) The Board at any time, and from time to time, may amend the Plan. 
However, except as provided in paragraph 9 relating to adjustments upon 
changes in stock, no amendment shall be effective unless approved by a 
majority of the outstanding shares of the Company entitled to vote within 
twelve (12) months before or after the adoption of the amendment, where the 
amendment will:

  (i) Increase the number of shares reserved for options under the Plan;

  (ii) Materially modify the requirements as to eligibility for participation
       in the Plan; or

  (iii) Materially increase the benefits accruing to participants under the
        Plan.

  It to expressly contemplated that the Board may amend the Plan in any 
respect the Board deems necessary or advisable to provide optionees with the 
maximum benefits provided or to be provided under the provisions of the Code 
and the regulations promulgated thereunder relating to employee incentive 
stock options and/or to bring the Plan and/or options granted under it into 
compliance therewith.

  (b) Rights and obligations under any option granted before amendment of the 
Plan shall not be altered or impaired by any amendment of the Plan, except 
with the consent of the person to whom the option was granted.

11.  TERMINATION OR SUSPENSION OF THE PLAN

  (a) The Board may suspend or terminate the Plan at any time. Unless sooner 
terminated, the Plan shall terminate within ten (10) years from the date the 
Plan is adopted by the Board or approved by the stockholders of the Company, 
whichever is earlier. No options may be granted under the Plan while the Plan 
is suspended or after it is terminated.

  (b) Rights and obligations under any option granted while the Plan is in 
effect shall not be altered or impaired by suspension or termination of the 
Plan, except with the consent of the person to whom the option was granted.

12.  EFFECTIVE DATE OF PLAN

  The Plan shall become effective as determined by the Board, but no options 
granted under the Plan shall be exercised unless and until the Plan has been 
approved by the holders of a majority of the outstanding shares of the Company 
entitled to vote, and, if required, an appropriate permit has been issued by 
the Commissioner of Corporations of the State of California.


                                GENENTECH, INC.

          1984 NON-QUALIFIED STOCK OPTION PLAN, AS AMENDED AND RESTATED
                         (Effective October 16, 1996)

1.  PURPOSE

  (a) The purpose of the Plan is to provide a means by which selected key 
employees and directors (if declared eligible under paragraph 4) of and 
consultants to GENENTECH, INC. (the "Company") and its affiliates, as defined 
in subparagraph 1(b), may be given an opportunity to purchase stock of the 
Company.

  (b) The word "affiliate" as used in the Plan means any Parent corporation or 
subsidiary corporation of the Company, as those terms are defined in Sections 
424(e) and (f), respectively, of the Internal Revenue Code of 1986, as amended 
(the "Code").

  (c) The Company, by means of the Plan, seeks to retain the services of 
persons now holding key positions to secure and retain the services of persons 
capable of filling such positions, and to provide incentives for such persons 
to exert maximum efforts for the success of the Company.

  (d) The Company intends that the options issued under the Plan not be 
incentive stock options as that term is used in Section 422 of the Code.

  (e) For purposes of the Plan, the following definitions shall apply:

  CLOSING SELLING PRICE:  The Closing Selling Price per share of Common Stock 
on any relevant date under the Plan shall be the closing selling price per 
share of Common Stock, if such Common Stock is reported on a national 
securities exchange or reported on the NASDAQ National Market System (or any 
successor system), for the trading day immediately preceding the date in 
question, as such price is published in the Wall Street Journal (or if such 
publication is not available, a comparable publication selected by the 
Committee).

  EMPLOYEE:  An individual shall be considered to be an Employee for so long 
as such individual remains in the employ of the Company or one or more of its 
parent or subsidiary corporations.

  SERVICE:  An individual shall be deemed to be in the Service of the Company 
for so long as such individual (i) renders service on a periodic basis to the 
Company or one or more of its parent or subsidiary corporations as an Employee 
or Consultant or (ii) is a member of the Company's Board of Directors (the 
"Board").

2.  ADMINISTRATION

  (a) The Plan shall be administered by the Compensation Committee (the 
"Committee"). The Committee shall be comprised of not less than three (3) 
Board members, none of whom shall be eligible to participate in this Plan or 
any other stock option, stock appreciation, stock bonus or other stock plan of 
the Company or its parent or subsidiary corporations (except to the extent 
such member becomes entitled to the special option grant to be made pursuant 
to automatic grant provisions of Section VII of Article Two or to option 
grants made pursuant to the automatic grant provisions of Article Three of the 
1990 Stock Option/ Stock Incentive Plan). The Board may from time to time 
appoint members to the Committee in substitution for (or in addition to) 
members previously appointed, and the Board shall have the authority to fill 
any and all vacancies on a Committee, however caused.

  (b) The Committee shall at all times have the authority to make 
discretionary option grants under the Plan to eligible Employees who are not 
members of the Board.

  (c) Subject to the express provisions of the Plan, the Committee shall have 
plenary authority:

    (i) To determine from time to time which of the persons eligible under the 
Plan shall be granted options; when and how the option shall be granted; the 
provisions of each option granted (which need not be identical), including the 
time or times during the term of each option within which all or portions of 
such option may be exercised; and the number of shares for which an option 
shall be granted to each such person.

    (ii) To construe and interpret the Plan and options granted under it, and 
to establish, amend and revoke rules and regulations for its administration. 
The Committee, in the exercise of this power, may correct any defeat, omission 
or inconsistency in the Plan or in any option agreement, in a manner and to 
the extent it shall deem necessary or expedient to make the Plan fully 
effective.

    (iii) Generally, to exercise such powers and to perform such acts as the 
Committee deems necessary or expedient to promote the best interests of the 
Company.

  (d) Determinations of the Committee on all matters relating to the Plan and 
any discretionary option grants or stock issuances made hereunder shall be 
final, binding and conclusive on all persons having any interest in the Plan 
or any options granted or shares issued under the Plan.

3.  SHARES SUBJECT TO THE PLAN

  (a) Subject to the provisions of paragraph 9 relating to adjustments upon 
changes in stock, the stock that may be sold pursuant to options granted under 
this Plan shall not exceed in the aggregate Fifteen Million Ninety Four 
Thousand Three Hundred and Ninety Seven (15,094,397) shares of the Company's 
common stock; provided, however, that such aggregate number of shares shall be 
reduced to reflect the number of shares of the Company's common stock which 
have been sold under, or may be sold pursuant to outstanding options granted 
under, the Company's 1984 Incentive Stock Option Plan (the "ISO Plan") to the 
same extent as if such sales had been made or options had been granted 
pursuant to this Plan. As used in this Plan, the "Company's common stock" 
includes all series of common stock authorized by the Company's charter 
documents, including the Common Stock and Earnings Convertible Restricted 
Stock now authorized and any other series that may in the future be 
authorized. If any option granted under this Plan or the ISO Plan shall for 
any reason expire or otherwise terminate without having been exercised in 
full, the stock not purchased under such option shall again become available 
for this Plan and the ISO Plan.

  (b) The stock subject to the Plan may be unissued shares or reacquired 
shares, bought on the market or otherwise.

  (c) There is no maximum limit on the aggregate fair market value (determined 
as of the times the respective options are granted) of the stock for which any 
eligible person may be granted options under the Plan in any calendar year.

  (d) Subject to the limitations contained elsewhere herein and to the 
provisions of paragraph 9 relating to adjustments upon changes in stock, the 
aggregate number of shares of stock that may be subject to options granted to 
all persons who are directors of the Company at the time such options are 
granted shall not exceed one million two hundred thousand (1,200,000) shares 
of the Company's common stock, and no single director of the Company who is 
not an employee of the Company or an affiliate thereof may be granted options 
to purchase more than forty thousand (40,000) shares of the Company's common 
stock; and no one director of the Company who is an employee of the Company or 
an affiliate thereof may be granted options to purchase more than six hundred 
thousand (600,000) shares of the Company's common stock.

4.  ELIGIBILITY

  (a) Options may be granted only to key employees (including officers) or 
directors of or consultants to the company or its affiliates.

  (b) A director shall in no event be eligible to be granted an option under 
the Plan unless and until such director is expressly declared eligible to 
participate in the Plan by action of the Committee.

  (c) Notwithstanding the above or any provision to the contrary set forth 
herein, no options shall be granted to any non-Employee director under this 
Plan after April 30, 1992.

5.  OPTION PROVISIONS

  Each option shall be in such form and shall contain such terms and 
conditions as the Committee shall deem appropriate. The provisions of separate 
options need not be identical, but each option shall include (through 
incorporation of provisions hereof by reference in the option or otherwise) 
the substance of each of the following provisions:

  (a) The term of any option shall not be greater than twenty (20) years from 
the date it was granted.

  (b) The exercise price of each option shall be not less than eighty-five 
percent (85%) of the fair market value of the stock subject to the option on 
the date the option is granted.

  (c) The purchase price of stock acquired pursuant to an option shall be 
paid, as specified in the option, either (i) in cash at the time the option is 
exercised, or (ii) at the discretion of the Committee, (A) by delivery to the 
Company of other shares of the Company's common stock, (B) according to a 
deferred payment or other arrangement (which may include, without limiting the 
generality of the foregoing, the use of other common stock of the Company) 
with the person to whom the option is granted or to whom the option is 
transferred pursuant to subparagraph 5(f), or (C) in any other form of legal 
consideration that may be acceptable to the Committee in their discretion, 
either at the time of grant or exercise of the option.

  In the case of any deferred payment arrangement specified at the time of 
grant, an interest rate shall be stated which is not less than the rate then 
specified which will prevent any imputation of higher interest under Section 
483 of the Code.

  (d) The total number of shares of stock subject to an option may, but need 
not, be allotted in periodic installments (which may, but need not, be equal). 
From time to time during each of such installment periods, the option may be 
exercised with respect to some or all of the shares allotted to that period, 
and/or with respect to some or all of the shares allotted to any prior period 
as to which the option was not fully exercised. During the remainder of the 
term of the option (if its term extends beyond the end of the installment 
periods), the option may be exercised from time to time with respect to any 
shares then remaining subject to the option. The provisions of this 
subparagraph 5(d) are subject to any option provisions governing the minimum 
number of shares as to which an option may be exercised.

  (e) The Company may require any optionee, or any person to whom an option is 
transferred under subparagraph 5(f), as a condition of exercising any such 
option to make such representations, warranties and agreements as the Company 
may deem appropriate to assure that issuance of the Company's common stock 
upon exercise of such option is in compliance with then applicable federal and 
state securities laws.

  (f) (1) Should an Optionee cease to continue in Service for any reason 
(other than termination due to death or permanent disability) while the holder 
of one or more outstanding options under this Plan, then such options shall 
not be exercisable at any time after the earlier of (i) the specified 
expiration date of the option term or (ii) the expiration of three (3) months 
after the Optionee's cessation of Service. Each such option shall, during the 
applicable period following cessation of Service, be exercisable only to the 
extent of the number of shares (if any) in which the Optionee is vested on the 
date of such cessation of Service; provided, however, that the Committee shall 
have the discretion to specify, either at the time the option is granted or at 
the time that the Optionee ceases Service, that vesting of such option may be 
accelerated and that the applicable period set forth in subclause (ii) may be 
increased, as provided in paragraph 8(a).

    (2) An option may be exercisable by the Optionee or, in the event the 
Optionee is permanently disabled (as such term is defined in Section 22(e)(3) 
of the Code), by his or her spouse or designee.  Options shall not be 
assignable or transferrable by the Optionee otherwise than by will or by the 
laws of descent and distribution.

    (3) Should an Optionee cease to continue in Service due to death or 
permanent disability while the holder of one or more outstanding options under 
this Plan, then such options shall not be exercisable at any time after the 
earlier of (i) the specified expiration date of the option term or (ii) the 
expiration of three (3) months after the Optionee's cessation of Service. Each 
such option shall, during the applicable period following cessation of 
Service, be exercisable only to the extent of the number of shares (if any) in 
which the Optionee in vested on the date of such cessation of Service; 
provided, however, that the Committee shall have the discretion to specify, 
either at the time the option is granted or at the time that the Optionee 
ceases Service, that the vesting of such option may be accelerated or extended 
from the date of cessation of Service and that the period of exercisability 
can be increased up to the expiration date of the option term.

    (4) Any option granted to an Optionee under this Plan and outstanding in 
whole or in part on the date of the Optionee's death may be subsequently 
exercised by the Personal representative of the Optionee's estate or by the 
person or persons to whom the option is transferred pursuant to the Optionee's 
will or in accordance with the laws of descent and distribution in the case of 
the Optionee's death, and any option granted to an Optionee under this Plan 
which is outstanding in whole or in part on the date of the Optionee's 
cessation of Service due to permanent disability may be exercised by the 
Optionee's spouse or designee. Any such exercise must be in accordance with 
clause (3).

  (g) The option may, but need not, include a provision whereby the optionee 
may elect at any time during the term of his or her employment with the 
Company or any affiliate to exercise the option as to any part or all of the 
shares subject to the option prior to the stated vesting date of the option or 
of any installment or installments specified in the option. Any shares so 
purchased from any unvested installment or option may be subject to a 
repurchase right in favor of the Company or to any other restriction the 
Committee determines to be appropriate.

  (h) Options may be granted to directors of the Company only during the first 
month of each calendar quarter. Any option held by a director of the Company 
may only be exercised during any period of ten business days beginning on the 
third business day after a quarterly or annual summary statement of the 
Company's revenues and earnings appears on a wire service or in a newspaper of 
general circulation, or is otherwise made generally available to the public.

6.  COVENANTS OF THE COMPANY

  (a) During the terms of the options granted under the Plan, the Company 
shall keep available at all times the number of shares of stock required to 
satisfy such options.

  (b) The Company shall seek to obtain from each regulatory commission or 
agency having jurisdiction over the Plan such authority as may be required to 
issue and sell shares of stock upon exercise of the options granted under the 
Plan; provided, however, that this undertaking shall not require the Company 
to register under the Securities Act of 1933, as amended, either the Plan, any 
option granted under the Plan or any stock issued or issuable pursuant to any 
such option. If the Company is unable to obtain from any such regulatory 
commission or agency the authority which counsel for the Company deems 
necessary for the lawful issuance and sale of stock under the Plan, the 
Company shall be relieved from any liability for failure to issue and sell 
stock upon exercise of such options unless and until such authority is 
obtained.

7.  USE OF PROCEEDS FROM STOCK

  Proceeds from the sale of stock pursuant to options granted under the Plan 
shall constitute general funds of the Company.

8.  MISCELLANEOUS

  (a) The Committee shall have the power to accelerate or increase the time 
during which an option any be exercised or the time during which the option or 
any part thereof will vest pursuant to subparagraph 5(d), notwithstanding the 
provisions in the option stating the time during which it may be exercised or 
the time during which it will vest.

  (b) Neither an optionee nor any person to whom an option is transferred 
under subparagraph 5(f) shall be deemed to be the holder of, or to have any of 
the rights of a holder with respect to, any shares subject to such option 
unless and until such person has satisfied all requirements for exercise of 
the option pursuant to its terms.

9.  ADJUSTMENTS UPON CHANGES IN STOCK

  (a) If any change is made in the stock subject to the Plan, or subject to 
any option granted under the Plan (through merger, consolidation, 
reorganization, recapitalization, stock dividend, dividend in property other 
than cash, stock split, liquidating dividend, combination of shares, exchange 
of shares, change in corporate structure or otherwise), the Committee shall 
make appropriate adjustments in the maximum number of shares subject to the 
Plan and the number of shares and price per share of stock subject to 
outstanding options.

  (b) In the event of a Change of Control (as defined in subparagraph 9(c)), 
then as to options which are not then exercisable, the time during which such 
options may be exercised shall be accelerated to the 60-day period from and 
after a Change of Control, unless, in the opinion of the Committee, it in 
clearly in the best interests of the optionholders and the shareholders taken 
together that the Company or a surviving corporation (if the Change of Control 
result as in the Company not surviving) assume any outstanding options or 
substitute similar options for those outstanding under the Plan, in which case 
the Committee may take appropriate action to effect an assumption or 
substitution.

  (c) "Change of Control" shall mean any of the following events:

    (1) the acquisition by any person (including a group, within the meaning 
of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as 
amended), other than the Company or any of its subsidiaries, of beneficial 
ownership (within the meaning of Rule 13d-3 promulgated under the Securities 
Exchange Act of 1934) as amended) of 50% or more of the combined voting power 
of the Company's then outstanding voting securities; or

    (2) approval by stockholders of the Company of a merger, consolidation, 
liquidation or dissolution of the Company or of the sale of all or 
substantially all of the Company's assets.

  (d) Notwithstanding any provision to the contrary set forth herein, the 
consummation of the merger contemplated by the Agreement and Plan of Merger 
dated as of May 23, 1995, among the Company, Roche Holdings, Inc. and HLR 
(U.S.) II, Inc. shall not be deemed to be a Change of Control under the Plan.

  (e) From and after October 25, 1995, all references herein to "shares", 
"stock", or "the Company's common stock" shall be deemed to be references to 
shares of Callable Putable Common Stock, par value $0.02 per share, of the 
Company ("Special Common Stock"), except for the references to the shares of 
Common Stock of the Company contained in subparagraph 9(g).

  (f) Notwithstanding any provision to the contrary set forth herein, in the 
event that the Special Common Stock is redeemed in accordance with Article 
THIRD, Section (c)(ii) of the Company's Certificate of Incorporation, any 
options granted under the Plan that are exercisable for Redeemable Common 
Stock and that are outstanding on the date of redemption (whether or not such 
options are exercisable on such date) shall become exercisable for 
consideration of the same type and amount as the holders thereof would have 
received had they exercised such options prior to such date of redemption.

  (g) Notwithstanding any provision to the contrary set forth herein, in the 
event that the shares of Special Common Stock are converted into shares of 
Common Stock, par value $0.02 per share, of the Company ("Common Stock") 
pursuant to Article THIRD, Section (c)(vi) of the Company's Certificate of 
Incorporation, each option granted under the Plan which is outstanding on the 
Conversion Date (as such term is defined in Article THIRD, Section (c)(vi) of 
the Company's Certificate of Incorporation) shall automatically be canceled, 
and the holder thereof shall receive, in exchange therefor, a substitute 
option to purchase, at a per share exercise price equal to the per share 
exercise price of such canceled option, the number of shares of Common Stock 
equal to the number of shares of Redeemable Common Stock subject to such 
canceled option. Such substitute option shall be subject to the same terms and 
conditions as the option for which it is exchanged, including with respect to 
vesting (such that such substitute option vests at the same time as the option 
for which it is exchanged would have vested) and the conditions relating to 
the exercise of the option. From and after the Conversion Date, all references 
herein to "shares", "stock", or the "Company's Common Stock" which in 
accordance with subparagraph 9(e) are deemed to be references to shares of 
Special Common Stock, shall be deemed to be references to shares of Common 
Stock.

10.  AMENDMENT OF THE PLAN

  (a) The Board at any time, and from time to time, may amend the Plan. 
However, except as provided in paragraph 9 relating to adjustments upon 
changes in stock, no amendment shall be effective unless approved by a 
majority of the outstanding shares of the Company entitled to vote within 
twelve (12) months before or after the adoption of the amendment, where the 
amendment will:

    (i) Increase the number of shares reserved for options under the Plan;

    (ii) Materially modify the requirements as to eligibility for 
participation in the Plan; or

    (iii) Materially increase the benefits accruing to participants under the 
Plan.

  (b) Rights and obligations under any option granted before amendment of the 
Plan shall not be altered or impaired by any amendment of the Plan, except 
with the consent of the person to whom the option was granted.

11.  TERMINATION OR SUSPENSION OF THE PLAN

  (a) The Board may suspend or terminate the Plan at any time. Unless sooner 
terminated, the Plan shall terminate within ten (10) years from the date the 
Plan is adopted by the Board or approved by the shareholders of the Company, 
whichever is earlier. No options may be granted under the Plan while the Plan 
is suspended or after it is terminated.

  (b) Rights and obligations under any option granted while the Plan is in 
effect shall not be altered or impaired by suspension or termination of the 
Plan, except with the consent of the person to whom the option was granted.

12.  EFFECTIVE DATE OF PLAN

  The Plan shall become effective as determined by the Board, but no options 
granted under the Plan shall be exercised unless and until the Plan has been 
approved by a majority of the outstanding shares of the Company entitled to 
vote, and, if required, an appropriate permit has been issued by the 
Commissioner of Corporations of the State of California.



                   1990 STOCK OPTION/STOCK INCENTIVE PLAN
                   (as amended effective October 16, 1996)

                                 ARTICLE ONE

                             GENERAL PROVISIONS

I.  PURPOSES OF THE PLAN

  A.  This 1990 Stock Option/Stock Incentive Plan (the "Plan") is intended to 
promote the interests of Genentech, Inc., a Delaware corporation (the 
"Company"), by providing a method whereby the Company may retain the services 
of persons now employed by or serving as consultants to it, secure and retain 
the services of persons capable of filling such positions and provide 
incentives for such persons to exert maximum efforts for the success of the 
Company or its parent or subsidiary corporations.

  B.  For purposes of the Plan, the following definitions shall be in effect:

     CHANGE IN CONTROL: "Change in Control" shall have the meaning set forth 
in Article Two, III.C. hereof.

     CHANGE IN CONTROL PRICE: "Change in Control Price" shall have the meaning 
set forth in Article Two, II.C.4.b. hereof.

     CLOSING SELLING PRICE: The Closing Selling Price per share of Common 
Stock on any relevant date under the Plan shall be the closing selling price 
per share of Common Stock, if such Common Stock is reported on a national 
securities exchange or reported on the NASDAQ National Market System (or any 
successor system), for the trading day immediately preceding the date in 
question, as such price is published in the Wall Street Journal (or if such 
publication is not available, a comparable publication selected by the 
Committee).

     COMMON STOCK: The Common Stock issuable under the Plan shall be shares of 
the Company's common stock, par value $0.02 per share. From and after October 
25, 1995, all references to "shares", "stock", or "common stock" shall be 
deemed to be references to shares of Callable Putable Common Stock, par value 
$0.02 per share (the "Special Common Stock"), of the Company.

     CONSULTANT: An individual shall be considered to be a Consultant for so 
long as such individual continues to render personal services to the Company 
or one or more of its parent or subsidiary corporations as an independent 
contractor.

     CORPORATE TRANSACTION: "Corporate Transaction" shall have the meaning set 
forth in Article Two, III.A. hereof.

     EMPLOYEE: An individual shall be considered to be an Employee for so long 
as such individual remains in the employ of the Company or one or more of its 
parent or subsidiary corporations.

     PARENT: A corporation shall be deemed to be a parent of the Company if it 
is a corporation (other than the Company) in an unbroken chain of corporations 
ending with the Company, provided each such corporation in the unbroken chain 
(other than the Company) owns, at the time of the determination, stock 
possessing fifty percent (50%) or more of the total combined voting power of 
all classes of stock in one of the other corporations in such chain.

     SECTION 16(b) INSIDER: An individual shall be considered to be a Section 
16(b) Insider on any relevant date under the Plan if such individual (A) is at 
the time an officer or director of the Company subject to the short-swing 
profit restrictions of the regulations promulgated under Section 16 of the 
Securities Exchange Act of 1934, as amended (the "1934 Act") or (B) unless 
Section 16 or regulations promulgated thereunder, are amended to provide 
otherwise, was such an officer or director at any time during the six month 
period immediately preceding the date in question and made any purchase or 
sale of Common Stock during such six-month period.

     SERVICE: An individual shall be deemed to be in the Service of the 
Company for so long as such individual (i) renders service on a periodic basis 
to the Company or one or more of its parent or subsidiary corporations as an 
Employee or Consultant or (ii) is a member of the Company's Board of Directors 
(the "Board").

     SUBSIDIARY: A corporation shall be deemed to be a subsidiary of the 
Company if it is one of the corporations (other than the Company) in an 
unbroken chain of corporations beginning with the Company, provided each such 
corporation (other than the last corporation in the unbroken chain) owns, at 
the time of determination, stock possessing 50 percent or more of the total 
combined voting power of all classes of stock in one of the other corporations 
in such chain. For purposes of nonstatutory option grants under Article Two 
and stock incentive grants under Article Three and all Corporate Transaction 
provisions of the Plan, the term "subsidiary" shall also include any 
partnership, joint venture or other business entity of which the Company owns, 
directly or indirectly through another subsidiary corporation, more than a 
fifty percent (50%) interest in voting power, capital or profits.

  C.  Neither stock option grants nor stock bonus issuances made to any 
individual under the Plan shall in any way affect, limit or restrict such 
individuals eligibility to participate in any other stock plan or other 
compensation or benefit plan, arrangement or practice now or hereafter 
maintained by the Company or any parent or subsidiary corporation.

II.  ADMINISTRATION OF THE PLAN

  A.  The Plan shall be administered by the Compensation Committee (the 
"Committee"). The Committee shall be comprised of not less than three (3) 
Board members.  The Board may from time to time appoint members to the 
Committee in substitution for (or in addition to) members previously 
appointed, and the Board shall have the authority to fill any and all 
vacancies on the Committee, however caused.

  B.  The Committee shall at all times have the authority to make 
discretionary option grants under the Plan to eligible Employees who are not 
members of the Board.

  C.  Subject to the express provisions of the Plan, the committee shall have 
plenary authority:

     (i)  to interpret the Plan, to prescribe, amend and rescind rules and 
regulations relating to it, and to make all other determinations deemed 
necessary or advisable in administering the Plan; and

     (ii) to change the terms and conditions of any outstanding discretionary 
option grant or unvested stock issuance, provided such action does not, 
without the consent of the holder, adversely affect the rights and obligations 
such individual may have under the Plan or the outstanding grant or stock 
issuance.

  D.  Determinations of the Committee on all matters relating to the Plan and 
any discretionary option grants or stock issuances made hereunder shall be 
final, binding and conclusive on all persons having any interest in the Plan 
or any options granted or shares issued under the Plan.

III.  STRUCTURE OF THE PLAN

  A.  The Plan shall be divided into three separate components: the Regular 
Option Grant Program specified in Article Two, the Automatic Grant Program 
specified in Article Three and the Stock Incentive Program specified in 
Article Four. Under the Regular Option Grant Program, eligible Employees, non-
Employee Board members  and Consultants may be granted options to purchase 
shares of Common Stock at an exercise price equal to not less than 50% of the 
Closing Selling Price per share on the grant date, and a special option grant 
is to be made in accordance with Section VII of Article Two. Under the 
Automatic Grant Program, non-Employee Board members shall automatically be 
granted options to purchase shares of Common Stock at an exercise price of 
100% of the Closing Selling Price per share of Common Stock on the date of 
grant, provided, however, that options granted under the Automatic Grant 
Program in 1990 shall have an exercise price per share equal to the Closing 
Selling Price on the date thirty (30) days after (i) the effective date of the 
Merger (defined in Article Six) or (ii) the termination date of the Merger 
Agreement (defined in Article Six), as applicable.

  B.  Under the Stock Incentive Program, eligible Employees, non-Employee 
Board members and Consultants may be awarded shares of Common Stock as a 
reward for past services or as an incentive to the performance of future 
services. Such shares may be issued as fully-vested shares or as shares 
vesting over time.

  C.  The provisions of Articles One, Five and Six of the Plan shall apply to 
the Regular Option Grant Program, the Automatic Option Grant Program and the 
Stock Incentive Program and shall accordingly govern the interests of all 
individuals in the Plan.

IV.  ELIGIBILITY FOR OPTION GRANTS AND STOCK ISSUANCES

  The individuals eligible to receive option grants ("Optionees") and/or stock 
incentives ("Recipients") pursuant to the Plan shall be limited to (i) those 
Employees, non-Employee Board members and Consultants selected by the 
Committee and (ii) those non-Employee Board members who are entitled to option 
grants pursuant to the Automatic Option Grant Program of Article Three.

V.  STOCK SUBJECT TO THE PLAN

  A.  The Common Stock issuable under the Plan shall be made available either 
from authorized but unissued shares of Common Stock or from shares of Common 
Stock reacquired by the Company on the open market. The aggregate number of 
shares of Common Stock issuable over the term of this Plan, whether through 
exercised options or direct stock issuances shall not exceed 11,500,000 shares 
(subject to adjustment from time to time in accordance with paragraphs C. and 
D. below).

  B.  Should an option granted under this Plan expire or terminate for any 
reason prior to exercise or surrender in full (including options canceled in 
accordance with the cancellation-regrant provisions of the Regular Option 
Grant Program), the shares subject to the portion of the option not so 
exercised or surrendered shall be available for subsequent option grants under 
this Plan. Shares subject to stock appreciation rights exercised in accordance 
with the Stock Appreciation Right provisions of Article Two and shares 
repurchased by the Company pursuant to its repurchase rights under the Plan 
shall not be available for subsequent issuance, whether through option grants, 
stock appreciation rights or direct issuances, under this Plan.

  C.  In the event any change is made to the Common Stock issuable under the 
Plan by reason of any stock dividend, stock split, combination of shares, 
exchange of shares or other change affecting the outstanding Common Stock as a 
class without receipt of consideration, then appropriate adjustments shall be 
made by the Committee to (i) the aggregate number and/or class of shares 
issuable under this Plan, the maximum number and/or class of shares 
purchasable per Employee-director pursuant to the applicable limitation of 
Section II.B of this Article One and the number and/or class of shares for 
which the special option grant is to be made pursuant to the automatic grant 
provisions of Section VII of Article Two and for which the automatic option 
grants are to be made pursuant to the provisions of Article Three, to reflect 
the effect of such change upon the Company's capital structure, (ii) the 
number and/or class of shares and the exercise price per share of the stock 
subject to each outstanding option in order to preclude the dilution or 
enlargement of benefits thereunder and (iii) the number and/or class of shares 
and the exercise price per share in effect under each outstanding stock 
appreciation right in order to preclude the dilution or enlargement of 
benefits thereunder. All adjustments made by the Committee pursuant to this 
paragraph C. shall be final, binding and conclusive.

  D.  Subject to the special priority provisions of Article Six of the Plan, 
in the event that (i) the Company is the surviving entity in any Corporate 
Transaction that does not result in the termination of outstanding options 
pursuant to the Corporate Transaction provisions of the Plan or (ii) the 
outstanding options under the Plan are to be assumed in connection with such 
Corporate Transaction, then each such continuing or assumed option shall, 
immediately after such Corporate Transaction, be appropriately adjusted to 
apply and pertain to the number and class of securities which would be 
issuable, in consummation of such Corporate Transaction, to an actual holder 
of the same number of shares of Common Stock as are subject to such option 
immediately prior to such Corporate Transaction. Appropriate adjustments shall 
also be made to the exercise price payable per share subject to each option, 
provided the aggregate exercise price of such option shall remain the same. In 
addition, the aggregate number and/or class of shares issuable under this Plan 
shall be appropriately adjusted to reflect the effect of such Corporate 
Transaction upon the Company's capital structure.


                                 ARTICLE TWO

                        REGULAR OPTION GRANT PROGRAM

I.  TERMS AND CONDITIONS OF OPTIONS

  A.  Except for the special option grant to be made pursuant to Section VII 
of this Article Two, the Committee shall have plenary authority (subject to 
the express provisions of the Plan and Section 144 of the Delaware General 
Corporation Law) to determine which Employees, non-Employee Board members and 
Consultants are to be granted options under this Regular Option Grant Program, 
the number of shares to be covered by each such option, the status of the 
granted option as either an incentive stock option ("Incentive Option") which 
meets the requirements of Section 422A of the Internal Revenue Code of 1986, 
as amended from time to time (the "Code"), or a non-statutory option not 
intended to meet such requirements, the time or times at which such option is 
to become exercisable, the time or times at which such option (or the Shares 
subject to such option) becomes vested (referred to herein as the "vesting 
schedule") and the term for which the option is to remain outstanding, up to a 
maximum term of twenty (20) years.

  B.  The granted options shall be evidenced by instruments in such form as 
the Committee shall from time to time approve; provided, however, that each 
such instrument (other than the instrument evidencing the special grant to be 
made under Section VII of this Article Two) shall comply with and incorporate 
the terms and conditions specified below, except as such terms and conditions 
must be modified for Incentive Options as set forth below in Section IV of 
this Article Two.

  1.  Exercise Price.

  a.  The exercise price per share shall be fixed by the Committee, but in no 
event shall the exercise price per share be less than fifty percent (50%) of 
the Closing Selling Price per share of Common Stock on the date of the option 
grant.

  b.  The exercise price shall become immediately due upon exercise of the 
option and shall, subject to the loan provisions of this Article Two, be 
payable in one of the alternative forms specified below:

     (A) full payment in cash or check made payable to the Company's order; or

     (B) full payment in shares of Common Stock held by the Optionee for the 
requisite period necessary to avoid a charge to the Company's reported 
earnings and valued at the Closing Selling Price on the Exercise Date (as such 
term is defined below); or
     (C) full payment in a combination of shares of Common Stock held by the 
Optionee for the requisite period necessary to avoid a charge to the Company's 
reported earnings and valued at the Closing Selling Price on the Exercise Date 
and cash or check.

  c.  For purposes of subparagraph b. above, the Exercise Date shall be the 
first date on which there is delivered to the Company both (I) written notice 
of the exercise of the option and (II) payment of the exercise price for the 
purchased shares.

  2.  Term and Exercise of Options.

  a.  Each option granted under this Regular Option Grant Program shall be 
exercisable in one or more installments over the Optionee's period of Service 
as shall be determined by the Committee and set forth in the instrument 
evidencing such option; provided, however, that no such option granted to a 
Section 16(b) Insider shall become exercisable in whole or in part within the 
first six (6) months after the grant date, except in the event of the 
Optionee's death or disability.

  b.  An option may be exercisable by the Optionee or, in the event the 
Optionee is permanently disabled (as such term is defined in Section 22(e) of 
the Code), by his or her spouse, and such option may be transferred by the 
Optionee to a trust for such Optionee's benefit or the benefit of an immediate 
family member or by will or the laws of descent or distribution.

  c.  The Committee may, at its discretion, accelerate the vesting schedule of 
any outstanding option at any time.

  3.  Termination of Service.

  a.  Should an Optionee cease to continue in Service for any reason (other 
than termination due to death, permanent disability or retirement from 
employment by the Company after reaching age sixty-five (65)) while the holder 
of one or more outstanding options under this Regular Option Grant Program, 
then such options shall not be exercisable at any time after the earlier of 
(i) the specified expiration date of the option term or (ii) the expiration of 
three (3) months after the Optionee's cessation of Service. Each such option 
shall, during the applicable period following cessation of Service, be 
exercisable only to the extent of the number of shares (if any) in which the 
Optionee is vested on the date of such cessation of Service; provided, 
however, that the Committee shall have the discretion to specify, either at 
the time the option is granted or at the time that the Optionee ceases 
Service, that vesting of such option may be extended for a period not to 
exceed three (3) years from the date of cessation of Service and that the 
applicable period set forth in clause (ii) may be increased to a period of up 
to five (5) years.

  b.  Should an Optionee cease to continue in Service due to permanent 
disability while the holder of one or more outstanding options under this 
Regular Option Grant Program, then such options shall not be exercisable at 
any time after the earlier of (i) the specified expiration date of the option 
term or (ii) the expiration of three (3) months after the Optionee's cessation 
of Service. Each such option shall, during the applicable period following 
cessation of Service, be exercisable only to the extent of the number of 
shares (if any) in which the Optionee is vested on the date of such cessation 
of Service; provided, however, that the Committee shall have the discretion to 
specify, either at the time the option is granted or at the time that the 
Optionee ceases Service, that the vesting of such option may be accelerated or 
extended from the date of cessation of Service and that the period of 
exercisability can be increased up to the expiration date of the option term.  
Should an Optionee cease to continue in Service due to death or retirement 
from employment by the Company after reaching age sixty-five (65), while the 
holder of one or more outstanding options under this Regular Option Grant 
Program, then all unvested options on such date shall automatically become 
vested and the expiration date of the option shall automatically be extended 
to the expiration date of the option term.

  c.  Any option granted to an Optionee under this Regular Option Grant 
Program and outstanding in whole or in part on the date of the Optionee's 
death may be subsequently exercised by the personal representative of the 
Optionee's estate or by the person or persons to whom the option is 
transferred pursuant to the Optionee's will or in accordance with the laws of 
descent and distribution in the case of the Optionee's death, and any option 
granted to an Optionee under this Regular Option Grant Program which is 
outstanding in whole or in part on the date of the Optionee's cessation of 
Service due to permanent disability may be exercised by the Optionee's spouse 
or designee. Any such exercise must be in accordance with subparagraph b.

  d.  The Committee shall have complete discretion, exercisable either at the 
time the option is granted or at the time the Optionee ceases Service, to 
establish as a provision applicable to the exercise of one or more options 
granted under this Regular Option Grant Program that during the limited period 
of exercisability following cessation of Service due to retirement, "plant 
closing" or "mass layoff" (as such terms are defined at 29 U.S.C. Section 
2101) that is subject to the notice requirements of 29 U.S.C. Section 2102, 
the option will continue to vest according to the vesting schedule that would 
have applied had the optionee continued in Service.

  4.  Repurchase Rights.

  a.  The shares of Common Stock acquired upon the exercise of one or more 
options granted under this Regular Option Grant Program may be subject to 
repurchase by the Company, at the exercise price paid per share, upon the 
Optionee's cessation of Service prior to vesting in such shares.

  b.  Any such repurchase right shall be exercisable by the Company upon such 
terms and conditions (including the establishment of the appropriate vesting 
schedule and other provision for the expiration of such right in one or more 
installments over the optionee's period of Service) as the Committee may 
specify in the instrument evidencing such right, which instrument shall 
include appropriate terms with respect to the legending of stock certificates 
and the placing of unvested shares into escrow.

  c.  All of the Company's outstanding repurchase rights shall automatically 
terminate, and all shares purchased under this Regular Option Grant Program 
shall immediately vest in full, upon the occurrence of any Corporate 
Transaction or Change in Control; provided, however, that no such termination 
of repurchase rights or immediate vesting of the purchased shares shall occur 
if (and to the extent that): (i) the Company's outstanding repurchase rights 
are to be assigned to the successor corporation (or parent thereof) in 
connection with the Corporate Transaction or (ii) such termination of 
repurchase rights and acceleration of vesting are precluded by other 
limitations imposed by the Committee either at the time the option is granted 
or at the time the option shares are purchased.

  5.  Stockholder Rights.

  An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by the option until such individual shall have exercised 
the option, paid the option price and satisfied all other conditions precedent 
to the issuance of certificates for the purchased shares.

II.  STOCK APPRECIATION RIGHTS

  A.  The Committee shall have full power and authority, exercisable in its 
sole discretion, to grant stock appreciation rights to one or more Employees, 
non-Employee Board members or Consultants eligible for option grants under 
this Regular Option Grant Program. Each such right shall entitle the holder to 
a distribution based on the appreciation in the value per share of a 
designated amount of Common Stock.

  B.  Three types of stock appreciation rights shall be authorized for 
issuance under the Plan:

  1. Tandem Stock Appreciation Rights.  These rights require the holder to 
elect between the exercise of the underlying option for shares of Common Stock 
and the surrender of such option for an appreciation distribution equal to the 
excess of (I) the Closing Selling Price (on the date of option surrender) of 
the vested shares of Common Stock purchasable under the surrendered option 
over (II) the aggregate option price payable for such shares.

  2. Concurrent Stock Appreciation Rights.  Concurrent rights may apply to all 
or any portion of the shares of Common Stock subject to the underlying option 
and will be exercised automatically at the same time the option is exercised 
for those shares. The appreciation distribution to which the holder of such 
concurrent right shall be entitled upon exercise of the underlying option 
shall be in an amount equal to the excess of (I) the aggregate Closing Selling 
Price (at date of exercise) of the vested shares purchased under the 
underlying option with such concurrent rights over (II) the aggregate option 
price paid for those shares.

  3. Limited Stock Appreciation Rights.  These rights will entitle the holder 
to surrender outstanding options in connection with certain Changes in Control 
(as defined below) for an appreciation distribution equal in amount to the 
excess of (I) the Change in Control Price (as defined below) of the number of 
shares in which the Optionee is at the time vested under the surrendered 
option over (II) the aggregate option price payable for such vested shares.

  C.  The terms and conditions applicable to each Tandem Stock Appreciation 
Right ("Tandem Right"), Concurrent Stock Appreciation Right ("Concurrent 
Right") and Limited Stock Appreciation Right ("Limited Right") shall be as 
follows:

  1.  Tandem Rights.

  a.  Tandem Rights may be tied to either Incentive Options or non-statutory 
options. Each such right shall, except as specifically set forth below, be 
subject to the same terms and conditions applicable to the particular stock 
option grant to which it pertains.

  b.  The Appreciation Distribution payable on the exercised Tandem Right 
shall be in an amount equal to the excess of (I) the Closing Selling Price (on 
the date of the option surrender) of the number of shares of Common Stock in 
which the Optionee is vested under the surrendered option over (II) the 
aggregate option price payable for such vested shares.

  c.  The Appreciation Distribution may, in the Committee's discretion, be 
made in cash, in shares of Common Stock or in a combination of cash and Common 
Stock. Any shares of Common Stock so distributed shall be valued at the 
Closing Selling Price on the date the option is surrendered, and the shares of 
Common Stock subject to the surrendered option shall not be available for 
subsequent issuance under this Plan.

  2.  Concurrent Rights.

  a.  Concurrent Rights may be tied to any or all of the shares of Common 
Stock subject to any Incentive Option or non-statutory option grant made under 
this Regular Option Grant Program. The Concurrent Right shall, except as 
specifically set forth below, be subject to the same terms and conditions 
applicable to the particular stock option grant to which it pertains.

  b.  The Concurrent Right shall be automatically exercised at the same time 
the underlying option is exercised for the particular shares of Common Stock 
to which the Concurrent Right pertains.

  c.  The Appreciation Distribution payable on the exercised Concurrent Right 
shall be equal to the excess of (I) the aggregate Closing Selling Price (on 
the Exercise Date) of the vested shares of Common Stock purchased under the 
underlying option which have Concurrent Rights appurtenant to them over (II) 
the aggregate option price paid for such shares.

  d.  The Appreciation Distribution may, in the Committee's discretion, be 
paid in cash, in shares of Common Stock or in a combination of cash and Common 
Stock. Any shares of Common Stock so distributed shall be valued at the 
Closing Selling Price on the date the Concurrent Right is exercised and shall 
reduce on a one-for-one basis the number of shares of Common Stock thereafter 
issuable under this Plan.

  3.  Terms Applicable to Both Tandem Rights and Concurrent Rights.

  a.  To exercise any outstanding Tandem or Concurrent Right, the holder must 
provide written notice of exercise to the Company in compliance with the 
provisions of the instrument evidencing such right.

  b.  If a Tandem or Concurrent Right is granted to an individual who is at 
the time a Section 16(b) Insider, then the instrument of grant shall 
incorporate all the terms and conditions at the time necessary to assure that 
the subsequent exercise of such right shall qualify for the safe-harbor 
exemption from short-swing profit liability provided by SEC Rule 16b-3 (or any 
successor rule or regulation).

  c.  No limitation shall exist on the aggregate amount of cash payments the 
Company may make under this Article Two Program in connection with the 
exercise of Tandem or Concurrent Rights.

  4.  Limited Rights.

  a.  Each Section 16(b) Insider shall have the Limited Right, exercisable in 
the event there should occur a Change in Control (as such term is defined 
below), to surrender any or all of the options (whether incentive stock 
options or non-statutory options) held by such individual under this Article 
Two Program, to the extent such options (I) have been outstanding for at least 
six (6) months and (II) are at the time exercisable for vested shares.

  b.  In exchange for each option surrendered in accordance with subparagraph 
a. above, the Section 16(b) Insider shall receive an Appreciation Distribution 
in an amount equal to the excess of (I) the Change in Control Price 
(determined as of the date of surrender) of the number of shares in which the 
Section 16(b) Insider is at the time vested under the surrendered option over 
(II) the aggregate option price payable for such vested shares. For purposes 
of such Appreciation Distribution, the Change in Control Price per share of 
the vested Common Stock subject to the surrendered option shall be deemed to 
be equal to the greater of (a) the Closing Selling Price per share on the date 
of surrender or (b) the highest reported price per share paid in effecting the 
Change in Control. However, if the option is an Incentive Option, then the 
Change in Control Price of the vested shares subject to the surrendered option 
shall not exceed the value per share determined under clause (a) above.

  c.  The Appreciation Distribution shall be made entirely in cash, and the 
shares of Common Stock subject to each surrendered option shall not be 
available for subsequent issuance under this Plan.

III.  CORPORATE TRANSACTION/CHANGE IN CONTROL

  A.  In the event of any of the following transactions (a "Corporate 
Transaction"):

  (i)  a merger or acquisition in which the Company is not the surviving 
entity, except for a transaction the principal purpose of which is to change 
the State of the Company's incorporation,

  (ii)  the sale, transfer or other disposition of all or substantially all of 
the assets of the Company to any entity other than a Subsidiary of the 
Company, or

  (iii)  any reverse merger in which the Company is the surviving entity but 
in which fifty percent (50%) or more of the Company's outstanding voting stock 
held by persons who are not "Subject Persons" as defined in Article Eleventh 
of the Company's Certificate of Incorporation (as in effect on the effective 
date of the Merger) including persons included in such definition by 
subparagraph (b) thereof is transferred to holders different from those who 
held the stock immediately prior to such merger, then the exercisability of 
each option outstanding under this Regular Option Grant Program shall be 
automatically accelerated so that each such option shall, immediately prior to 
the specified effective date for the Corporate Transaction, become fully 
exercisable with respect to the total number of shares of Common Stock 
purchasable under such option and may be exercised for all or any portion of 
such shares. However, an outstanding option under this Regular Option Grant 
Program shall not be so accelerated if and to the extent: (i) such option is, 
in connection with the Corporate Transaction, either to be assumed by the 
successor corporation or parent thereof or be replaced with a comparable 
option to purchase shares of the capital stock of the successor corporation or 
parent thereof, or (ii) such option is to be replaced by a comparable cash 
incentive program of the successor corporation based on the value of the 
option at the time of the Corporate Transaction, or (iii) the acceleration of 
such option is subject to other applicable limitations imposed by the 
Committee at the time of grant. The determination of comparability under 
clause (i) or (ii) above shall be made by the Committee, and its determination 
shall be final, binding and conclusive.

  B.  Upon the consummation of the Corporate Transaction, all outstanding 
options under this Regular Option Grant Program shall, to the extent not 
previously exercised or assumed by the successor corporation or its parent 
company, terminate and cease to be outstanding.

  C.  In the event of any of the following transactions (a "Change in 
Control"):

  (i)  the acquisition by a person or group of related persons, other than the 
Company or any person controlling, controlled by or under common control with 
the Company, of beneficial ownership (as determined pursuant to the provisions 
of Rule 13d-3 under the Securities Exchange Act of 1934, as amended) of 
securities of the Company representing thirty percent (30%) or more of the 
combined voting power of the Company's then outstanding securities pursuant to 
a transaction or series of related transactions which the Board does not 
approve; or

  (ii)  the first date within any period of thirty-six (36) consecutive months 
or less on which there is effected any change in the composition of the Board 
such that the majority of the Board (determined by rounding up to the next 
whole number) ceases to be comprised of individuals who either (I) have been 
members of the Board continuously since the beginning of such period or (II) 
have been elected or nominated for election as Board members during such 
period by at least a majority of the Board members described in clause (I) who 
were still in office at the time such election or nomination was approved by 
the Board; then the exercisability of each option outstanding under this 
Regular Option Grant Program shall be automatically accelerated so that each 
such option shall become exercisable, immediately prior to such Change in 
Control, for the full number of shares purchasable under such option and may 
be exercised for all or any portion of such shares. However, an outstanding 
option under this Regular Option Grant Program shall not be so accelerated if 
and to the extent one or more limitations imposed by the Committee at the time 
of grant preclude such acceleration upon a Change in Control.

  D.  The grant of options under this Regular Option Grant Program shall in no 
way affect the right of the Company to adjust, reclassify, reorganize or 
otherwise change its capital or business structure or to merge, consolidate, 
dissolve, liquidate or sell or transfer all or any part of its business or 
assets.

IV.  INCENTIVE OPTIONS

  A.  The terms and conditions specified below shall be applicable to all 
Incentive Options granted under this Regular Option Grant Program. Options 
which are specifically designated as "nonstatutory" options when issued under 
this Regular Option Grant Program shall not be subject to such terms and 
conditions.

  1.  Option Price.

  The option price per share of the Common Stock subject to an Incentive 
Option shall in no event be less than one hundred percent (100%) of the 
Closing Selling Price per share of Common Stock on the grant date.

  2.  10% Stockholder.

  If any individual to whom an Incentive Option is to be granted pursuant to 
the provisions of this Regular Option Grant Program is on the grant date the 
owner of stock (as determined under Section 424(d) of the Internal Revenue 
Code) possessing 10% or more of the total combined voting power of all classes 
of stock of the Company or any one of its parent or subsidiary corporations 
(such person to be herein referred to as a 10% Stockholder), then (i) the 
option price per share shall not be less than one hundred and ten percent 
(110%) of the Closing Selling Price per share of Common Stock on the grant 
date and (ii) the maximum term of the option shall not exceed five (5) years 
from the grant date.

  3.  Dollar Limitation.

  The aggregate fair market value (determined on the basis of the Closing 
Selling Price in effect on the respective date or dates of grant) of the 
Common Stock for which one or more options granted to any Employee under this 
Plan (or any other option plan of the Company or its parent or subsidiary 
corporations) may for the first time become exercisable as incentive stock 
options under the Federal tax laws during any one calendar year shall not 
exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the 
Employee holds two or more such options which become exercisable for the first 
time in the same calendar year, the foregoing limitation on the exercisability 
thereof as incentive stock options under the Federal tax laws shall be applied 
on the basis of the order in which such options are granted.

  4.  Term and Exercise of Options.

  a.  No Incentive Option shall have a term in excess of ten (10) years from 
the grant date.

  b.  An Incentive Option shall not be transferable except by will or by the 
laws of descent and distribution and shall be exercisable during the lifetime 
of the Optionee only by the Optionee.

  5.  Termination of Service.

  A.  An Incentive Option must be exercised within the three (3)-month period 
commencing with the date of cessation of Employee status for any reason other 
than death, except that in the event the Optionee's cessation of Employee 
status is due to permanent disability, such period shall be one (1) year from 
the date of such cessation of Employee status. Incentive Options not exercised 
within the applicable period shall be treated as non-statutory options.

  B.  Except as modified by the preceding provisions of this Incentive Options 
section, all the provisions of this Regular Option Grant Program shall be 
applicable to the Incentive Options granted hereunder.

V.  CANCELLATION AND RE-GRANT OF OPTIONS

  The Committee shall have the authority to effect, at any time and from time 
to time, with the consent of the affected option holders, the cancellation of 
any or all outstanding options under this Regular Option Grant Program (other 
than the special grant to be made pursuant to Section VII of this Article Two) 
and to grant in substitution therefor new options under this Plan covering the 
same or different numbers of shares of Common Stock but having an option price 
per share not less than fifty percent (50%) of the Closing Selling Price (one 
hundred percent (100%) of the Closing Selling Price in the case of an 
Incentive Option or, in the case of a 10% Stockholder, not less than one 
hundred and ten percent (110%) of the Closing Selling Price) per share of 
Common Stock on the new grant date.

VI.  LOANS OR GUARANTEE OF LOANS

  The Committee may assist any Employee (including any officer or director) in 
the exercise of one or more options under this Regular Option Grant Program 
(other than the special grant to be made pursuant to Section VII of this 
Article Two) by (a) authorizing the extension of a loan to such Employee from 
the Company, (b) permitting the Employee to pay the option price for the 
purchased Common Stock in installments over a period of years or (c) 
authorizing a guarantee by the Company of a third-party loan to the Employee. 
The terms of any loan, installment method of payment or guarantee (including 
the interest rate and terms of repayment) shall be established by the 
Committee in its sole discretion. Loans, installment payments and guarantees 
may be granted without security or collateral, but the maximum credit 
available to the Optionee shall not exceed the sum of (i) the aggregate 
exercise price (less the par value) of the purchased shares plus (ii) any 
Federal and State income and employment tax liability incurred by the Employee 
in connection with the exercise of the option.

VII.  SPECIAL OPTION GRANT

  [RESERVED]

                                ARTICLE THREE

                           AUTOMATIC GRANT PROGRAM

I.  AUTOMATIC GRANTS

  On July 18, 1990, each individual who is a non-Employee member of the Board 
on such date shall automatically be granted a nonstatutory option under this 
Article Three to purchase 15,000 shares of Common Stock. On April 30, 1992, 
each individual who is a non-Employee member of the Board on such date shall 
automatically be granted a non-statutory option under this Article Three to 
purchase 15,000 shares of Common Stock. Each non-Employee who is first elected 
a member of the Board after such date shall automatically be granted, on the 
date of such individual's election to the Board, a non-statutory option under 
this Article Three to purchase 15,000 shares of Common Stock. Each Employee 
director who is first elected a member of the Board and who subsequently 
becomes a non-Employee director after January 1, 1992 shall automatically be 
granted, on the date of such individual's change from Employee to non-
Employee, a non- statutory option under this Article Three to purchase 15,000 
shares of Common Stock. This provision shall terminate on April 30, 1995.

II.  TERMS AND CONDITIONS OF GRANT

  Each option granted in accordance with the provisions of this Article Three 
shall be evidenced by an instrument in such form as the Committee approves 
from time to time for grants made under Article Two; provided, however, that 
each such automatic grant shall be subject to the following terms and 
conditions:

  A.  Exercise Price.

  The exercise price per share shall be one hundred percent (100%) of the 
Closing Selling Price per share of Common Stock on the grant date; provided, 
however, that options granted under this Article Three in 1990 shall have an 
exercise price per share equal to the Closing Selling Price on the date thirty 
(30) days after (i) the effective date of the Merger (defined in Article Six) 
or (ii) the termination date of the Merger Agreement (defined in Article Six), 
as applicable.

  B.  Term and Vesting of Options.

  1.  Except as otherwise specified below, each option shall vest in 
increments of 5,000 shares on the first, second and third anniversaries of the 
grant date and shall thereafter remain exercisable until the expiration or 
earlier termination of the option term.

  2.  Each granted option shall have a term of ten (10) years measured from 
the grant date.

  C.  Exercise of Option.

  Upon exercise of the option, the option exercise price for the purchased 
shares shall become immediately due and payable in full in one of the 
alternative forms specified below:

  (i)  cash or check payable to the Company's order;

  (ii)  shares of Common Stock held by the optionee for the requisite period 
necessary to avoid a charge to the Company's reported earnings and valued at 
the Closing Selling Price on the date of exercise; or

  (iii)  any combination of the foregoing so long as the total payment equals 
the aggregate exercise price for the purchased shares.

  D.  Effect of Termination of Board Membership.

  1.  Should an optionee cease to be a member of the Board for any reason 
(other than death) prior to the expiration date of one or more automatic 
grants held by the optionee under this Article Three, then each such grant 
shall remain exercisable, for any shares of Common Stock for which the option 
is exercisable at the time of such cessation of Board membership, for a period 
not to exceed the earlier of (i) the expiration of the three (3)-month period 
following the date of such cessation of Board membership or (ii) the specified 
expiration date of the option term.

  2.  Should the optionee's membership on the Board cease by reason of death, 
then each outstanding grant held by the optionee under this Article Three may 
be subsequently exercised, for any shares of Common Stock for which the option 
is exercisable at the time of the optionee's cessation of Board membership, by 
the personal representative of the optionee's estate or by the person or 
persons to whom the option is transferred pursuant to the optionee's will or 
in accordance with the laws of descent and distribution. Any such exercise 
must, however, occur prior to the earlier of (i) the expiration of the twelve 
(12)-month period following the date of the optionee's death or (ii) the 
specified expiration date of the option term.

  E.  Stockholder Rights.

  An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by an option granted under this Article Three until such 
individual shall have exercised the option, paid the option exercise price in 
full and satisfied all other conditions precedent to the issuance of 
certificates for the purchased shares.

III.  CORPORATE TRANSACTION

  A.  In the event of one or more of the following transactions (a "Corporate 
Transaction"):

  (i)  a merger or acquisition in which the Company is not the surviving 
entity, except for a transaction the principal purpose of which is to change 
the State of the Company's incorporation;

  (ii)  the sale, transfer or other disposition of all or substantially all of 
the assets of the Company to any entity other than a Subsidiary of the 
Company; or

  (iii)  any reverse merger in which the Company is the surviving entity but 
in which fifty percent (50%) or more of the Company's outstanding voting stock 
held by persons who are not "Subject Persons" as defined in Article Eleventh 
of the Company's Certificate of Incorporation (as in effect on the effective 
date of the Merger) including persons included in such definition by 
subparagraph (b) thereof is transferred to holders different from those who 
held the stock immediately prior to such merger; then each option grant under 
this Article Three outstanding at the time and not otherwise at the time fully 
exercisable shall automatically accelerate and become exercisable for any or 
all of the shares subject to the option immediately prior to the specified 
effective date for the Corporate Transaction. Upon the consummation of such 
Corporate Transaction, all outstanding options granted under this Article 
Three shall, to the extent not previously exercised by the optionee or assumed 
by the successor corporation or its parent company, terminate and cease to be 
outstanding.

  B.  The Automatic Grant Program in effect under this Article Three shall in 
no way affect the right of the Company to adjust, reclassify, reorganize or 
otherwise change its capital or business structure or to merge, consolidate, 
dissolve, liquidate or sell or transfer all or any part of its business or 
assets.

IV.  CHANGE IN CONTROL

  A.  In the event of one or more of the following transactions (a "Change in 
Control"):

  (i)  the acquisition by a person or group of related persons, other than the 
Company or any person controlling, controlled by or under common control with 
the Company, of beneficial ownership (as determined pursuant to the provisions 
of Rule 13d-3 under the Securities Exchange Act of 1934, as amended) of 
securities of the Company representing thirty percent (30%) or more of the 
combined voting power of the Company's then outstanding securities pursuant to 
a transaction or series of related transactions which the Board does not 
approve; or

  (ii)  the first date within any period of thirty-six (36) consecutive months 
or less on which there is effected any change in the composition of the Board 
such that the majority of the Board (determined by rounding up to the next 
whole number) ceases to be comprised of individuals who either (I) have been 
members of the Board continuously since the beginning of such period or (II) 
have been elected or nominated for election as Board members during such 
period by at least a majority of the Board members described in clause (I) who 
were still in office at the time such election or nomination was approved by 
the Board; then all outstanding options granted under this Article Three and 
not otherwise at the time fully exercisable shall automatically accelerate 
upon the Change in Control and thereby become exercisable for any or all 
option shares. In addition, each option grant under this Article Three which 
has been outstanding for at least six (6) months may be surrendered, on the 
tenth (10th) business day following the Change in Control, in exchange for a 
cash payment from the Company in an amount equal to the excess of (i) the Fair 
Market Value (on the date of such surrender) of the shares of Common Stock 
subject to the surrendered option over (ii) the aggregate option price payable 
for such shares.

  B.  For purposes of subparagraph A above, the Fair Market Value per share of 
Common Stock subject to the surrendered option shall be deemed to be equal to 
the greater of (a) the Closing Selling Price per share on the date of such 
surrender, as determined in accordance with the normal valuation provisions of 
the Plan, or if applicable, (b) the highest reported price per share paid in 
acquiring ownership of the fifty percent (50%) or greater interest in the 
Company's outstanding voting securities.


                                ARTICLE FOUR

                          STOCK INCENTIVE PROGRAM

I.  TERMS AND CONDITIONS OF STOCK ISSUANCES

  A.  Shares may be issued under this Stock Incentive Program as a reward for 
past services rendered the Company or one or more of its parent or subsidiary 
corporations or as an incentive for future service with such entities. Any 
unvested shares so issued shall be evidenced by a Restricted Stock Issuance 
Agreement ("Issuance Agreement") which complies with the terms and conditions 
of this Stock Incentive Program and shall include appropriate terms with 
respect to legending of certificates and escrow of unvested shares.

  1.  Vesting Schedule.

  a.  The Recipient's interest in the issued shares of Common Stock may, in 
the absolute discretion of the Committee, be fully and immediately vested upon 
issuance or may vest in one or more installments.

  b.  The elements of the vesting schedule applicable to any unvested shares 
issued under this Stock Incentive Program, namely the number of installments 
in which the shares are to vest, the interval or intervals (if any) which are 
to lapse between installments and the effect which death, disability or other 
event designated by the Committee is to have upon the vesting schedule, shall 
be determined by the Committee and set forth in the Issuance Agreement 
executed by the Company and the Recipient at the time of the incentive grant.

  c.  Except as may otherwise be provided in the Issuance Agreement, the 
Recipient may not transfer unvested shares of Common Stock. The Recipient, 
however, shall have all the rights of a stockholder with respect to such 
unvested shares, including without limitation the right to vote such shares 
and to receive all dividends paid on such shares.

  2.  Cancellation of Shares.

  a.  In the event the Recipient should, while his/her interest in the issued 
Common Stock remains unvested, cease to continue in Service for any reason 
whatsoever, then the Company shall have the right to cancel all such unvested 
shares, and the Recipient shall thereafter have no further stockholder rights 
with respect to such shares.

  b.  The Committee may in its discretion waive such cancellation of unvested 
shares in whole or in part and thereby effect the immediate vesting of the 
Recipient's interest in the shares of Common Stock (or other assets) as to 
which the waiver applies.

  3.  Corporate Transaction/Change in Control.

  All unvested shares under the Stock Incentive Program shall immediately vest 
in full immediately prior to the occurrence of any Corporate Transaction or 
Change in Control, except to the extent:

  (i)  the Company's outstanding cancellation rights are to be assigned to the 
successor corporation (or parent thereof) in connection with the Corporate 
Transaction, or

  (ii)  one or more limitations imposed by the Committee at the time of stock 
issuance preclude such accelerated vesting.


                                ARTICLE FIVE

                                MISCELLANEOUS

I.  TAX WITHHOLDING

  A.  The Company's obligation to deliver shares upon the exercise or 
surrender of stock options or stock appreciation rights granted under Article 
Two or Article Three or upon the issuance or vesting of shares under Article 
Four shall be subject to the satisfaction of all applicable Federal, State and 
local income and employment tax withholding requirements.

  B.  The Committee may, in its discretion and upon such terms and conditions 
as it may deem appropriate (including the applicable safe-harbor provisions of 
SEC Rule 16b-3 or any successor rule or regulation) provide any or all 
Optionees or Recipients with the election to have the Company withhold, from 
the shares of Common Stock purchased or issued under the Plan, one or more of 
such shares with an aggregate Closing Selling Price equal to the designated 
percentage (up to 100% specified by the Optionee or Recipient) of the Federal 
and State income taxes ("Taxes") incurred in connection with the acquisition 
of such shares. In lieu of such direct withholding, one or more Optionees or 
Recipients may also be granted the right to deliver shares of Common Stock to 
the Company in satisfaction of such Taxes. The withheld or delivered shares 
shall be valued at the Closing Selling Price on the applicable determination 
date for such Taxes.

II.  AMENDMENT OF THE PLAN

  A.  The Board shall have the complete and exclusive authority to amend or 
modify the Plan in any or all respects whatsoever; provided, however, that no 
such amendment or modification shall, without the consent of the holders, 
adversely affect rights and obligations with respect to any stock options, 
stock appreciation rights or unvested Common Stock at the time outstanding 
under the Plan. In addition, with a view to making available the benefits 
provided by Section 422A of the Code and/or SEC Rule 16b-3 as in effect from 
time to time under the 1934 Act, the Board shall, at the time of each such 
amendment, determine whether or not to submit such amendment of the Plan to 
the Company's stockholders for approval.

  B.  No material amendments shall be made to the provisions of the Article 
Three Program without the approval of the Company's stockholders.

III.  EFFECTIVE DATE AND TERM OF PLAN

  A.  The Plan shall become effective when adopted by the Board, but no stock 
option or stock appreciation right granted under the Plan shall become 
exercisable, and no shares shall be issued, unless and until the Plan shall 
have been approved by the Company's stockholders. If such stockholder approval 
is not obtained within twelve (12) months after the date of the Board's 
adoption of the Plan, then all stock options and stock appreciation rights 
previously granted under the Plan shall terminate and no further stock options 
or stock appreciation rights shall be granted. Subject to such limitation, the 
Committee may grant stock options and stock appreciation rights under the Plan 
at any time after the effective date and before the date fixed herein for 
termination of the Plan.

  B.  The Plan shall in all events terminate on the date determined by the 
Board. Upon such termination, any stock options, stock appreciation rights and 
unvested shares at the time outstanding under the Plan shall continue to have 
force and effect in accordance with the provisions of the instruments 
evidencing such grants or issuances.

  C.  Options may be granted under this Plan to purchase shares of Common 
Stock in excess of the number of shares then available for issuance under the 
Plan, provided (i) an amendment to increase the maximum number of shares 
issuable under the Plan is adopted by the Board prior to the initial grant of 
any such option and within one year thereafter such amendment is approved by 
the Company's stockholders, if such stockholder approval is deemed necessary 
by the Board, and (ii) each option granted is not to become exercisable, in 
whole or in part, at any time prior to the obtaining of such stockholder 
approval, and provided further that at any time that the Amended and Restated 
Governance Agreement dated as of October 25, 1995 between the Company and 
Roche Holdings, Inc. (the "Amended Governance Agreement") remains in effect, 
any action by the Board pursuant to the foregoing shall require the approval 
of a majority of the Independent Directors (as such term is defined in Article 
Eleventh of the Certificate of Incorporation of the Company).

IV.  MISCELLANEOUS PROVISIONS

  A.  Any cash proceeds received by the Company from the issuance of shares 
hereunder shall be used for general corporate purposes.

  B.  The implementation of the Plan, the granting of any stock option or 
stock appreciation right hereunder, and the issuance of Common Stock under the 
Regular Option Grant, the Automatic Option Grant or Stock Incentive Programs 
shall be subject to the Company's procurement of all approvals and permits 
required by regulatory authorities having jurisdiction over the Plan, the 
stock options and stock appreciation rights granted under it and the Common 
Stock issued pursuant to it.

  C.  Neither the action of the Company in establishing the Plan, nor any 
action taken by the Board or the Committee hereunder, nor any provision of the 
Plan itself shall be construed so as to grant any individual the right to 
remain in the employ or service of the Company or any of its parent or 
subsidiary corporations for any period of specific duration, and the Company 
(or any parent or subsidiary retaining the services of such individual) may 
terminate such individual's employment or service at any time and for any 
reason, with or without cause.

  D.  Nothing contained in the Plan shall be construed to limit the authority 
of the Company to exercise its corporate rights and powers, including (without 
limitation) the right of the Company (a) to grant options for proper corporate 
purposes otherwise than under this Plan to any Employee or other person, firm 
or company or association or (b) to grant options to, or assume the option of, 
any person in connection with the acquisition (by purchase, lease, merger, 
consolidation or otherwise) of the business and assets (in whole or in part) 
of any person, firm, company or association.


                                ARTICLE SIX

                         SPECIAL MERGER PROVISIONS

I.  PRIORITY

  The provisions of this Article Six shall govern any and all options under 
this Plan which have been granted prior to, or are granted following, the 
effective date of the merger of the Company with and into HLR (U.S.) II, Inc. 
(the "Merger") pursuant to that certain Agreement and Plan of Merger ("Merger 
Agreement") dated May 23, 1995 among the Company, Roche Holdings, Inc., and 
HLR (U.S.) II, Inc. To the extent there is a conflict between any of the 
provisions of this Article Six and any other provision of the Plan, the 
specific provisions of this Article Six shall be controlling and shall govern 
the disposition of all such options outstanding at the time of the Merger.

II.  OPTION ADJUSTMENTS

  A.  None of the options granted under this Plan prior to the effective date 
of the Merger shall be accelerated in whole or in part in connection with the 
Merger.

  B.  None of the options granted under this Plan prior to the effective date 
of the Merger shall be cashed out, or otherwise entitle the option holders to 
any cash payments, in connection with the consummation of the Merger.

  C.  Each option granted under this Plan prior to the effective date of the 
Merger shall remain in effect after the Merger upon the same terms and 
conditions (including, without limitation, the exercise price per share and 
the number of shares) in effect for such option immediately prior to the 
Merger, except that the shares purchasable under each such continuing option 
shall be shares of Special Common Stock. Each such continuing option will 
become exercisable, and the shares purchasable thereunder shall vest, in 
accordance with the same installment dates such option would have become 
exercisable, and such shares would have vested, under the vesting schedule 
specified for that option at the time of grant.

III.  PLAN ADJUSTMENTS

  A.  After the effective date of the Merger, all references in the Plan to 
Common Stock shall automatically become references to Special Common Stock.

  B.  If the Special Common Stock shall be redeemed at any time as provided in 
Section (c)(ii) of Article Third of the Certificate of Incorporation of the 
Company, then all outstanding options and stock appreciation rights granted 
hereunder shall automatically accelerate and become fully exercisable and 
vested immediately prior to the date fixed for redemption, and upon such 
redemption the holder of such option or stock appreciation right shall 
promptly be paid for each such option or right an amount equal to the product 
of (i) the excess of the redemption price per share fixed in Section (c)(ii) 
of Article Third (without reduction for the payment of any cash dividends as 
provided in the fourth sentence of Section (c)(ii)(C) of Article Third) over 
the exercise price per share, times (ii) the number of shares covered by such 
option or right. Upon such redemption, any of the redemption price to be paid 
pursuant to Section (c)(ii) of Article Third of the Certificate of 
Incorporation of the Company received by a holder of shares issued under the 
Stock Incentive Program in respect of unvested shares shall be placed in 
escrow and released to such holder in accordance with the vesting schedule 
that would have applied to such shares had such redemption not taken place.

  C.  Neither the consummation of the Merger nor the exercise by Roche 
Holdings, Inc. or its affiliates of its right to designate nominees to the 
Board of Directors pursuant to Sections 3.01 and 3.02 of the Amended 
Governance Agreement, nor any change in the composition of the Board of 
Directors resulting therefrom, shall constitute a Change in Control.

  D.  Upon the conversion of the Special Common Stock into Common Stock, all 
references in the Plan to Special Common Stock (as provided in Article Five, 
III. A.) shall automatically become references to Common Stock. Each option 
granted under this Plan prior to such conversion shall remain in effect after 
such conversion upon the same terms and conditions (including, without 
limitation, the exercise price per share and the number of shares) in effect 
for such option immediately prior to such conversion, except that the shares 
purchasable under each such continuing option shall be shares of Common Stock. 
Each such continuing option will become exercisable, and the shares 
purchasable thereunder shall vest, in accordance with the same installment 
dates such option would have become exercisable, and such shares would have 
vested, under the vesting schedule specified for that option at the time of 
grant.



                            1994 STOCK OPTION PLAN
                   (as amended effective October 16, 1996)

                                 ARTICLE ONE

                             GENERAL PROVISIONS

I.  PURPOSES OF THE PLAN

  A. This 1994 Stock Option Plan (the "Plan") is intended to promote the 
interests of Genentech, Inc., a Delaware corporation (the "Company"), by 
providing a method whereby the Company may retain the services of persons now 
employed by or serving as consultants or directors to it, secure and retain 
the services of persons capable of filling such positions and provide 
incentives for such persons to exert maximum efforts for the success of the 
Company or its parent or subsidiary corporations.

  B. For purposes of the Plan, the following definitions shall be in effect:

  CHANGE IN CONTROL: "Change in Control" shall have the meaning set forth in 
Article Two, II.C. hereof.

  CLOSING SELLING PRICE: The Closing Selling Price per share of Special Common 
Stock on any relevant date under the Plan shall be the closing selling price 
per share of Special Common Stock, if such Special Common Stock is reported on 
a national securities exchange or reported on the NASDAQ National Market 
System (or any successor system), for the trading day immediately preceding 
the date in question, as such price is published in the Wall Street Journal 
(or if such publication is not available, a comparable publication selected by 
the Committee).

  CONSULTANT: An individual shall be considered to be a Consultant for so long 
as such individual continues to render personal services to the Company or one 
or more of its parent or subsidiary corporations as an independent contractor.

  CORPORATE TRANSACTION: "Corporate Transaction" shall have the meaning set 
forth in Article Two, II. A. hereof.

  EMPLOYEE: An individual shall be considered to be an Employee for so long as 
such individual remains in the employ of the Company or one or more of its 
Parent or Subsidiary.

  PARENT: A corporation shall be deemed to be a parent of the Company if it is 
a corporation (other than the Company) in an unbroken chain of corporations 
ending with the Company, provided each such corporation in the unbroken chain 
(other than the Company) owns, at the time of the determination, stock 
possessing fifty percent (50%) or more of the total combined voting power of 
all classes of stock in one of the other corporations in such chain.

  SECTION 16(b) INSIDER: An individual shall be considered to be a Section 
16(b) Insider on any relevant date under the Plan if such individual (A) is at 
the time an officer or director of the Company subject to the short-swing 
profit restrictions of the regulations promulgated under Section 16 of the 
Securities Exchange Act of 1934, as amended (the "1934 Act") or (B) unless 
Section 16 or regulations promulgated thereunder are amended to provide 
otherwise, was such an officer or director at any time during the six month 
period immediately preceding the date in question and made any purchase or 
sale of Special Common Stock during such six-month period.

  SERVICE: An individual shall be deemed to be in the Service of the Company 
for so long as such individual renders service on a periodic basis to the 
Company or one or more of its Parent or Subsidiaries as an Employee or 
Consultant.

  SPECIAL COMMON STOCK: The Special Common Stock issuable under the Plan shall 
be shares of the Company's Callable Putable Common Stock, par value $0.02 per 
share.

  SUBSIDIARY: A corporation shall be deemed to be a subsidiary of the Company 
if it is one of the corporations (other than the Company) in an unbroken chain 
of corporations beginning with the Company, provided each such corporation 
(other than the last corporation in the unbroken chain) owns, at the time of 
determination, stock possessing 50 percent or more of the total combined 
voting power of all classes of stock in one of the other corporations in such 
chain. For purposes of nonstatutory option grants under Article Two and all 
Corporate Transaction provisions of the Plan, the term "subsidiary" shall also 
include any partnership, joint venture or other business entity of which the 
Company owns, directly or indirectly through another subsidiary corporation, 
more than a fifty percent (50%) interest in voting power, capital or profits.

  C. Stock option grants made to any individual under the Plan shall not in 
any way affect, limit or restrict such individual's eligibility to participate 
in any other stock plan or other compensation or benefit plan, arrangement or 
practice now or hereafter maintained by the Company or any Parent or 
Subsidiary.

II.  ADMINISTRATION OF THE PLAN

  A. The Plan shall be administered by the Compensation Committee (the 
"Committee"). The Committee shall be comprised of not less than two (2) Board 
members.  The Board may from time to time appoint members to the Committee in 
substitution for (or in addition to) members previously appointed, and the 
Board shall have the authority to fill any and all vacancies on the Committee, 
however caused. 

  B. Subject to limitations contained elsewhere herein and to the provisions 
of Section IV., C. and D. of this Article I relating to adjustments upon 
changes in stock, the aggregate number of shares of stock that may be subject 
to options granted to any Employee in a calendar year shall not exceed two 
hundred fifty thousand (250,000) shares of the Company's Special Common Stock.

  C. Subject to the express provisions of the Plan, the Committee shall have 
plenary authority:

  (i) to interpret the Plan, to prescribe, amend and rescind rules and 
regulations relating to it, and to make all other determinations deemed 
necessary or advisable in administering the Plan; and

  (ii) to change the terms and conditions of any outstanding discretionary 
option grant or unvested stock issuance, provided such action does not, 
without the consent of the holder, adversely affect the rights and 
obligations such individual may have under the Plan or an outstanding grant.

  D. Determinations of the Committee on all matters relating to the Plan and 
any discretionary option grants made hereunder shall be final, binding and 
conclusive on all persons having any interest in the Plan or any options 
granted issued under the Plan.

III.  STRUCTURE OF THE PLAN

A. The Plan shall be divided into two separate components: the Option Grant 
Program specified in Article Two and the Automatic Grant Program specified in 
Article Three. Under the Option Grant Program, eligible Employees, non-
Employee Board members and Consultants may be granted options to purchase 
shares of Special Common Stock at an exercise price equal to not less than 50% 
of the Closing Selling Price per share on the grant date. Under the Automatic 
Grant Program, non-Employee Board members shall automatically be granted 
options to purchase shares of Special Common Stock on the dates and in the 
amounts specified in Article Three below at an exercise price of 100% of the 
Closing Selling Price per share of Special Common Stock on the date of grant.

B.  The provisions of Articles One, Four and Five of the Plan shall apply 
to the the Option Grant Program and the Automatic Option Grant Program and 
shall accordingly govern the interests of all individuals in the Plan.

IV.  ELIGILBILITY FOR OPTION GRANTS

   The individuals eligible to receive option grants ("Optionees") pursuant to 
the Plan shall be limited to (i) those Employees, non-Employee Board members  
and Consultants selected by the Committee; and (ii) those non-Employee Board 
members who are entitled to option grants pursuant to the Automatic Option 
Grant Program of Article Three.

V.  STOCK SUBJECT TO THE PLAN

  A. The Special Common Stock issuable under the Plan shall be made available 
either from authorized but unissued shares of Special Common Stock or from 
shares of Special Common Stock reacquired by the Company on the open market. 
The aggregate number of shares of Special Common Stock issuable over the term 
of this Plan, whether through exercised options or direct stock issuances, 
shall not exceed 4,500,000 shares (subject to adjustment from time to time in 
accordance with subparagraphs C. and D. below).

  B. Should an option granted under this Plan expire or terminate for any 
reason prior to exercise or surrender in full (including options canceled in 
accordance with the cancellation-regrant provisions of the Option Grant 
Program), the shares subject to the portion of the option not so exercised or 
surrendered shall be available for subsequent option grants under this Plan. 
Shares repurchased by the Company pursuant to its repurchase rights under the 
Plan shall not be available for subsequent issuance.

  C. In the event any change is made to the Special Common Stock issuable 
under the Plan by reason of any stock dividend, stock split, combination of 
shares, exchange of shares or other change affecting the outstanding Special 
Common Stock as a class without receipt of consideration, then appropriate 
adjustments shall be made by the Committee to (i) the aggregate number and/or 
class of shares issuable under this Plan and the maximum number and/or class 
of shares purchasable per Employee pursuant to the applicable limitation of 
Section II.B of this Article One and the number and/or class of shares for 
which the automatic option grants are to be made pursuant to the provisions of 
Article Three, to reflect the effect of such change upon the Company's capital 
structure, and (ii) the number and/or class of shares and the exercise price 
per share of the stock subject to each outstanding option in order to preclude 
the dilution or enlargement of benefits thereunder. All adjustments made by 
the Committee pursuant to this subparagraph C. shall be final, binding and 
conclusive.

  D. Subject to the special priority provisions of Article Five of the Plan, 
in the event that (i) the Company is the surviving entity in any Corporate 
Transaction that does not result in the termination of outstanding options 
pursuant to the Corporate Transaction provisions of the Plan or (ii) the 
outstanding options under the Plan are to be assumed in connection with such 
Corporate Transaction, then each such continuing or assumed option shall, 
immediately after such Corporate Transaction, be appropriately adjusted to 
apply and pertain to the number and class of securities which would be 
issuable, in consummation of such Corporate Transaction, to an actual holder 
of the same number of shares of Special Common Stock as are subject to such 
option immediately prior to such Corporate Transaction. Appropriate 
adjustments shall also be made to the exercise price payable per share subject 
to each option, provided that the aggregate exercise price of such option 
shall remain the same. In addition, the aggregate number and/or class of 
shares issuable under this Plan shall be appropriately adjusted to reflect the 
effect of such Corporate Transaction upon the Company's capital structure.


                                 ARTICLE TWO

                            OPTION GRANT PROGRAM

I.  TERMS AND CONDITIONS OF OPTIONS

  A. The Committee shall have plenary authority (subject to the express 
provisions of the Plan and Section 144 of the Delaware General Corporation 
Law) to determine which Employees, non-Employee Board members and Consultants 
are to be granted options under this Option Grant Program, the number of 
shares to be covered by each such option, the status of the granted option as 
either an incentive stock option ("Incentive Option") which meets the 
requirements of Section 422 of the Internal Revenue Code of 1986, as amended 
from time to time (the "Code"), or a non-statutory option not intended to meet 
such requirements, the time or times at which such option is to become 
exercisable, the time or times at which such option (or the Shares subject to 
such option) becomes vested (referred to herein as the "vesting schedule") and 
the term for which the option is to remain outstanding, up to a maximum term 
of twenty (20) years.

  B. The granted options shall be evidenced by instruments in such form as the 
Committee shall from time to time approve; provided, however, that each such 
instrument shall comply with and incorporate the terms and conditions 
specified below, except as such terms and conditions must be modified for 
Incentive Options as set forth below in Section III of this Article Two.

     1.  Exercise Price.

  a. The exercise price per share shall be fixed by the Committee, but in no 
event shall the exercise price per share be less than fifty percent (50%) of 
the Closing Selling Price per share of Special Common Stock on the date of the 
option grant.

  b. The exercise price shall become immediately due upon exercise of the 
option and shall, subject to the loan provisions of this Article Two, be 
payable in one of the alternative forms specified below:

     (A) full payment in cash or check made payable to the Company's order; or

     (B) full payment in shares of Special Common Stock held by the Optionee 
for the requisite period necessary to avoid a charge to the Company's reported 
earnings and valued at the Closing Selling Price on the Exercise Date (as such 
term is defined below); or

     (C) full payment in a combination of shares of Special Common Stock held 
by the Optionee for the requisite period necessary to avoid a charge to the 
Company's reported earnings and valued at the Closing Selling Price on the 
Exercise Date and cash or check.

  c. For purposes of subparagraph b. above, the Exercise Date shall be the 
first date on which there is delivered to the Company both (i) written notice 
of the exercise of the option and (ii) payment of the exercise price for the 
purchased shares.

     2.  Term and Exercise of Options.

  a. Each option granted under this Option Grant Program shall be exercisable 
in one or more installments over the Optionee's period of Service as shall be 
determined by the Committee and set forth in the instrument evidencing such 
option; provided, however, that no such option granted to a Section 16(b) 
Insider shall become exercisable in whole or in part within the first six (6) 
months after the grant date, except in the event of the Optionee's death or 
disability.

  b. An option may be exercisable by the Optionee or, in the event the 
Optionee is permanently disabled (as such term is defined in Section 22(e) of 
the Code), by his or her spouse, and such option may be transferred by the 
Optionee to a trust for such Optionee's benefit or the benefit of an immediate 
family member or by will or the laws of descent or distribution.

  c. The Committee may, at its discretion, accelerate the vesting schedule of 
any outstanding option at any time.

     3.  Termination of Service.

  a. Should an Optionee cease to continue in Service for any reason (other 
than termination due to death, permanent disability or retirement from 
employment by the Company after reaching age sixty-five (65)) while the holder 
of one or more outstanding options under this Option Grant Program, then such 
options shall not be exercisable at any time after the earlier of (i) the 
specified expiration date of the option term or (ii) the expiration of three 
(3) months after the Optionee's cessation of Service. Each such option shall, 
during the applicable period following cessation of Service, be exercisable 
only to the extent of the number of shares (if any) in which the Optionee is 
vested on the date of such cessation of Service; provided, however, that the 
Committee shall have the discretion to specify, either at the time the option 
is granted or at the time that the Optionee ceases Service, that vesting of 
such option may be extended for a period not to exceed three (3) years from 
the date of cessation of Service and that the applicable expiration period set 
forth in clause (ii) may be increased to a period of up to five (5) years.

  b. Should an Optionee cease to continue in Service due to permanent 
disability while the holder of one or more outstanding options under this 
Option Grant Program, then such options shall not be exercisable at any time 
after the earlier of (i) the specified expiration date of the option term or 
(ii) the expiration of three (3) months after the Optionee's cessation of 
Service. Each such option shall, during the applicable period following 
cessation of Service, be exercisable only to the extent of the number of 
shares (if any) in which the Optionee is vested on the date of such cessation 
of Service; provided, however, that the Committee shall have the discretion to 
specify, either at the time the option is granted or at the time that the 
Optionee ceases Service, that the vesting of such option may be accelerated or 
extended from the date of cessation of Service and that the period of 
exercisability can be increased up to the expiration date of the option term. 
Should an Optionee cease to continue in Service due to death or retirement 
from employment by the Company after reaching age sixty-five (65), while the 
holder of one or more outstanding options under this Regular Option Grant 
Program, then all unvested options on such date shall automatically become 
vested and the expiration date of the option shall automatically be extended 
to the expiration date of the option term.

  c. Any option granted to an Optionee under this Option Grant Program and 
outstanding in whole or in part on the date of the Optionee's death may be 
subsequently exercised by the personal representative of the Optionee's estate 
or by the person or persons to whom the option is transferred pursuant to the 
Optionee's will or in accordance with the laws of descent and distribution in 
the case of the Optionee's death, and any option granted to an Optionee under 
this Option Grant Program which is outstanding in whole or in part on the date 
of the Optionee's cessation of Service due to permanent disability may be 
exercised by the Optionee's spouse or designee. Any such exercise must be in 
accordance with subparagraph b.

  d. The Committee shall have complete discretion, exercisable either at the 
time the option is granted or at the time the Optionee ceases Service, to 
establish as a provision applicable to the exercise of one or more options 
granted under this Option Grant Program that during the limited period of 
exercisability following cessation of Service due to retirement, "plant 
closing" or "mass layoff" (as such terms are defined at 29 U.S.C. Section 
2101) that is subject to the notice requirements of 29 U.S.C. Section 2102, 
the option will continue to vest according to the vesting schedule that would 
have applied had the Optionee continued in Service.


     4.  Repurchase Rights.

  a. Options may provide that notwithstanding any vesting schedule pursuant to 
subparagraph 2.a. above, they may be exercised prior to such vesting schedule 
so long as the Optionee enters into a repurchase agreement satisfactory to the 
Company. The shares of Special Common Stock acquired upon the exercise of one 
or more options granted under this Option Grant Program may be subject to 
repurchase by the Company, at the exercise price paid per share, upon the 
Optionee's cessation of Service prior to vesting in such shares.

  b. Any such repurchase right shall be exercisable by the Company upon such 
terms and conditions (including the establishment of the appropriate vesting 
schedule and other provision for the expiration of such right in one or more 
installments over the Optionee's period of Service) as the Committee may 
specify in the instrument evidencing such right, which instrument shall 
include appropriate terms with respect to the legending of stock certificates 
and the placing of unvested shares into escrow.

  c. All of the Company's outstanding repurchase rights shall automatically 
terminate, and all shares purchased under this Option Grant Program shall 
immediately vest in full, upon the occurrence of any Corporate Transaction or 
Change in Control; provided, however, that no such termination of repurchase 
rights or immediate vesting of the purchased shares shall occur if (and to the 
extent that): (i) the Company's outstanding repurchase rights are to be 
assigned to the successor corporation (or parent thereof) in connection with 
the Corporate Transaction or (ii) such termination of repurchase rights and 
acceleration of vesting are precluded by other limitations imposed by the 
Committee either at the time the option is granted or at the time the option 
shares are purchased.

     5.  Stockholder Rights.

  An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by the option until such individual shall have exercised 
the option, paid the option price and satisfied all other conditions precedent 
to the issuance of certificates for the purchased shares.

II.  CORPORATE TRANSACTION/CHANGE IN CONTROL

  A. In the event of any of the following transactions (a "Corporate 
Transaction"):

  (i) a merger or acquisition in which the Company is not the surviving 
entity, except for a transaction the principal purpose of which is to change 
the State of the Company's incorporation,

  (ii) the sale, transfer or other disposition of all or substantially all of 
the assets of the Company to any entity other than a Subsidiary of the 
Company, or

  (iii) any reverse merger in which the Company is the surviving entity but in 
which fifty percent (50%) or more of the Company's outstanding voting stock 
held by persons who are not "Subject Persons" as defined in Article Eleventh 
of the Company's Certificate of Incorporation (as in effect on September 7, 
1990) including persons included in such definition by subparagraph (b) 
thereof is transferred to holders different from those who held the stock 
immediately prior to such merger, then the exercisability of each option 
outstanding under this Option Grant Program shall be automatically accelerated 
so that each such option shall, immediately prior to the specified effective 
date for the Corporate Transaction, become fully exercisable with respect to 
the total number of shares of Special Common Stock purchasable under such 
option and may be exercised for all or any portion of such shares. However, an 
outstanding option under this Option Grant Program shall not be so accelerated 
if and to the extent: (i) such option is, in connection with the Corporate 
Transaction, either to be assumed by the successor corporation or parent 
thereof or be replaced with a comparable option to purchase shares of the 
capital stock of the successor corporation or parent thereof, or (ii) such 
option is to be replaced by a comparable cash incentive program of the 
successor corporation based on the value of the option at the time of the 
Corporate Transaction, or (iii) the acceleration of such option is subject to 
other applicable limitations imposed by the Committee at the time of grant. 
The determination of comparability under clause (i) or (ii) above shall be 
made by the Committee, and its determination shall be final, binding and 
conclusive.

  B. Upon the consummation of the Corporate Transaction, all outstanding 
options under this Option Grant Program shall, to the extent not previously 
exercised or assumed by the successor corporation or its parent company, 
terminate and cease to be outstanding.

  C. In the event of any of the following transactions (a "Change in 
Control"):

  (i) the acquisition by a person or group of related persons, other than the 
Company or any person controlling, controlled by or under common control with 
the Company, of beneficial ownership (as determined pursuant to the provisions 
of Rule 13d-3 under the 1934 Act) of securities of the Company representing 
thirty percent (30%) or more of the combined voting power of the Company's 
then outstanding securities pursuant to a transaction or series of related 
transactions which the Board does not approve; or

  (ii) the first date within any period of thirty-six (36) consecutive months 
or less on which there is effected any change in the composition of the Board 
such that the majority of the Board (determined by rounding up to the next 
whole number) ceases to be comprised of individuals who either (I) have been 
members of the Board continuously since the beginning of such period or (II) 
have been elected or nominated for election as Board members during such 
period by at least a majority of the Board members described in clause (I) who 
were still in office at the time such election or nomination was approved by 
the Board; then the exercisability of each option outstanding under this 
Option Grant Program shall be automatically accelerated so that each such 
option shall become exercisable, immediately prior to such Change in Control, 
for the full number of shares purchasable under such option and may be 
exercised for all or any portion of such shares. However, an outstanding 
option under this Option Grant Program shall not be so accelerated if and to 
the extent one or more limitations imposed by the Committee at the time of 
grant preclude such acceleration upon a Change in Control.

  D. The grant of options under this Option Grant Program shall in no way 
affect the right of the Company to adjust, reclassify, reorganize or otherwise 
change its capital or business structure or to merge, consolidate, dissolve, 
liquidate or sell or transfer all or any part of its business or assets.

III.  INCENTIVE OPTIONS

  A. The terms and conditions specified below shall be applicable to all 
Incentive Options granted under this Option Grant Program. Options which are 
specifically designated as "non-statutory" options when issued under this 
Option Grant Program shall not be subject to such terms and conditions.

     1.  Option Price.

  The option price per share of the Special Common Stock subject to an 
Incentive Option shall in no event be less than one hundred percent (100%) of 
the Closing Selling Price per share of Special Common Stock on the grant date.

     2.  10% Stockholder.

  If any individual to whom an Incentive Option is to be granted pursuant to 
the provisions of this Option Grant Program is on the grant date the owner of 
stock (as determined under Section 424(d) of the Internal Revenue Code) 
possessing 10% or more of the total combined voting power of all classes of 
stock of the Company or any one of its Parent or Subsidiaries (such person to 
be herein referred to as a 10% Stockholder), then (i) the option price per 
share shall not be less than one hundred and ten percent (110%) of the Closing 
Selling Price per share of Special Common Stock on the grant date and (ii) the 
maximum term of the option shall not exceed five (5) years from the grant 
date.

     3.  Dollar Limitation.

  The aggregate fair market value (determined on the basis of the Closing 
Selling Price in effect on the respective date or dates of grant) of the 
Special Common Stock for which one or more options granted to any Employee 
under this Plan (or any other option plan of the Company or its Parent or 
Subsidiaries) may for the first time become exercisable as incentive stock 
options under the Federal tax laws during any one calendar year shall not 
exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the 
Employee holds two or more such options which become exercisable for the first 
time in the same calendar year, the foregoing limitation on the exercisability 
thereof as incentive stock options under the Federal tax laws shall be applied 
on the basis of the order in which such options are granted.

     4.  Term and Exercise of Options.

  a. No Incentive Option shall have a term in excess of ten (10) years from 
the grant date.

  b. An Incentive Option shall not be transferable except by will or by the 
laws of descent and distribution and shall be exercisable during the lifetime 
of the Optionee only by the Optionee.

     5.  Termination of Service.

  Notwithstanding any term in the Plan to the contrary, an Incentive Option 
must be exercised within the three (3) month period commencing with the date 
of cessation of Employee status for any reason, except that in the event the 
Optionee's cessation of Employee status is due to permanent disability, such 
period shall be one (1) year from the date of such cessation of Employee 
status. Incentive Options not exercised within the applicable period shall be 
treated as non-statutory options.

  B. Except as modified by the preceding provisions of this Incentive Options 
section, all the provisions of this Option Grant Program shall be applicable 
to the Incentive Options granted hereunder. If any option originally granted 
as an Incentive Stock Option is modified so as not to qualify under the Code 
as an Incentive Stock Option, such modified Incentive Stock Option shall be a 
non-statutory option.

IV.  CANCELLATION AND RE-GRANT OF OPTIONS

  The Committee shall have the authority to effect, at any time and from time 
to time, with the consent of the affected option holders, the cancellation of 
any or all outstanding options under this Option Grant Program and to grant in 
substitution therefor new options under this Plan covering the same or 
different numbers of shares of Special Common Stock but having an option price 
per share not less than fifty percent (50%) of the Closing Selling Price (one 
hundred percent (100%) of the Closing Selling Price in the case of an 
Incentive Option or, in the case of a 10% Stockholder, not less than one 
hundred and ten percent (110%) of the Closing Selling Price) per share of 
Special Common Stock on the new grant date.

V.  LOANS OR GUARANTEE OF LOANS

  The Committee may assist any Employee (including any officer or director) in 
the exercise of one or more options under this Option Grant Program by (a) 
authorizing the extension of a loan to such Employee from the Company, (b) 
permitting the Employee to pay the option price for the purchased Special 
Common Stock in installments over a period of years or (c) authorizing a 
guarantee by the Company of a third-party loan to the Employee. The terms of 
any loan, installment method of payment or guarantee (including the interest 
rate and terms of repayment) shall be established by the Committee in its sole 
discretion. Loans, installment payments and guarantees may be granted without 
security or collateral, but the maximum credit available to the Optionee shall 
not exceed the sum of (i) the aggregate exercise price (less the par value) of 
the purchased shares plus (ii) any Federal and State income and employment tax 
liability incurred by the Employee in connection with the exercise of the 
option.



                               ARTICLE THREE

                          AUTOMATIC GRANT PROGRAM

I.  AUTOMATIC GRANTS

  On April 30, 1995, each individual who is a non-Employee member of the Board 
on such date shall automatically be granted a non-statutory option under this 
Article Three to purchase 15,000 shares of Special Common Stock. Each non-
Employee who is first appointed or elected a member of the Board after April 
30, 1995 shall automatically be granted, on the date of such individual's 
election to the Board, a non-statutory option under this Article Three to 
purchase 15,000 shares of Special Common Stock. Each Employee director who is 
first elected a member of the Board and who subsequently becomes a non-
Employee director after April 30, 1995 shall automatically be granted, on the 
date of such individual's change from Employee to non-Employee director, a 
non-statutory option under this Article Three to purchase 15,000 shares of 
Special Common Stock.  This provision shall terminate on April 30, 1996.

II.  TERMS AND CONDITIONS OF GRANT

  Each option granted in accordance with the provisions of this Article Three 
shall be evidenced by an instrument in such form as the Committee approves 
from time to time for grants made under Article Two; provided, however, that 
each such automatic grant shall be subject to the following terms and 
conditions:

     A.  Exercise Price.

  The exercise price per share shall be one hundred percent (100%) of the 
Closing Selling Price per share of Special Common Stock on the grant date.

     B.  Term and Vesting of Options.

  1.  Except as otherwise specified below, each option shall vest in 
increments of 5,000 shares on the first, second and third anniversaries of the 
grant date and shall thereafter remain exercisable until the expiration or 
earlier termination of the option term.

  2.  Each granted option shall have a term of ten (10) years measured from 
the grant date.

     C.  Exercise of Option.

  Upon exercise of the option, the option exercise price for the purchased 
shares shall become immediately due and payable in full in one of the 
alternative forms specified below:

     (i) cash or check payable to the Company's order;

     (ii) shares of Special Common Stock held by the optionee for the 
requisite period necessary to avoid a charge to the Company's reported 
earnings and valued at the Closing Selling Price on the date of exercise; or

     (iii) any combination of the foregoing so long as the total payment 
equals the aggregate exercise price for the purchased shares.

     D.  Effect of Termination of Board Membership.

  1.  Should an Optionee cease to be a member of the Board for any reason 
(other than death) prior to the expiration date of the automatic grant held by 
the optionee under this Article Three, then such grant shall remain 
exercisable, for any shares of Special Common Stock for which the option is 
exercisable at the time of such cessation of Board membership, for a period 
not to exceed the earlier of (i) the expiration of the three (3) month period 
following the date of such cessation of Board membership or (ii) the specified 
expiration date of the option term.

  2.  Should the Optionee's membership on the Board cease by reason of death, 
then each outstanding grant held by the optionee under this Article Three may 
be subsequently exercised, for any shares of Special Common Stock for which 
the option is exercisable at the time of the Optionee's cessation of Board 
membership, by the personal representative of the Optionee's estate or by the 
person or persons to whom the option is transferred pursuant to the optionee's 
will or in accordance with the laws of descent and distribution. Any such 
exercise must, however, occur prior to the earlier of (i) the expiration of 
the twelve (12) month period following the date of the Optionee's death or 
(ii) the specified expiration date of the option term.

  E.  Stockholder Rights.

  An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by an option granted under this Article Three until such 
individual shall have exercised the option, paid the option exercise price in 
full and satisfied all other conditions precedent to the issuance of 
certificates for the purchased shares.

III.  CORPORATE TRANSACTION

  A. In the event of a Corporate Transaction, options granted under the 
Automatic Grant Program shall be treated as described in Section II of Article 
Two, except the provisions of clause (iii) of the penultimate sentence of 
Section II A(iii) of Article Two shall not apply.

IV.  CHANGE IN CONTROL

  A. In the event of a Change in Control, options granted under the Automatic 
Grant Program shall be treated as described in Section II of Article Two, 
except the last sentence of Section II C.(ii) of Article Two shall not apply.

                                ARTICLE FOUR

                                MISCELLANEOUS

I.  TAX WITHHOLDING

  A. The Company's obligation to deliver shares upon the exercise or surrender 
of stock options granted under Article Two shall be subject to the 
satisfaction of all applicable Federal, State and local income and employment 
tax withholding requirements.

  B. The Committee may, in its discretion and upon such terms and conditions 
as it may deem appropriate (including the applicable safe-harbor provisions of 
SEC Rule 16b-3 or any successor rule or regulation) provide any or all 
Optionees or Recipients with the election to have the Company withhold, from 
the shares of Special Common Stock purchased or issued under the Plan, one or 
more of such shares with an aggregate Closing Selling Price equal to the 
designated percentage (up to 100% specified by the Optionee or Recipient) of 
the Federal and State income taxes ("Taxes") incurred in connection with the 
acquisition of such shares. In lieu of such direct withholding, one or more 
Optionees or Recipients may also be granted the right to deliver unrestricted 
shares of Special Common Stock to the Company in satisfaction of such Taxes. 
The withheld or delivered shares shall be valued at the Closing Selling Price 
on the applicable determination date for such Taxes.

II.  AMENDMENT OF THE PLAN

  A. The Board shall have the complete and exclusive authority to amend or 
modify the Plan in any or all respects whatsoever; provided, however, that no 
such amendment or modification shall, without the consent of the holders, 
adversely affect rights and obligations with respect to any stock options then 
outstanding under the Plan. In addition, with a view to making available the 
benefits provided by Section 422 of the Code and/or SEC Rule 16b-3 as in 
effect from time to time under the 1934 Act, the Board shall, at the time of 
each such amendment, determine whether or not to submit such amendment of the 
Plan to the Company's stockholders for approval.

  B. No material amendments shall be made to the provisions of the Automatic 
Grant Program without the approval of the Company's stockholders.

III.  EFFECTIVE DATE AND TERM OF PLAN

  A. The Plan shall become effective when adopted by the Board, but no stock 
option granted under the Plan shall become exercisable, and no shares shall be 
issued, unless and until the Plan shall have been approved by the Company's 
stockholders. If such stockholder approval is not obtained within twelve (12) 
months after the date of the Board's adoption of the Plan, then all stock 
options previously granted under the Plan shall terminate and no further stock 
options shall be granted. Subject to such limitation, the Committee may grant 
stock options under the Plan at any time after the effective date and before 
the date fixed herein for termination of the Plan.

  B. The Plan shall in all events terminate on the date determined by the 
Board, but in no event shall the Plan terminate later than February 22, 2004. 
Upon such termination, any stock options at the time outstanding under the 
Plan shall continue to have force and effect in accordance with the provisions 
of the instruments evidencing such grants.

  C. Options may be granted under this Plan to purchase shares of Special 
Common Stock in excess of the number of shares then available for issuance 
under the Plan, provided (i) an amendment to increase the maximum number of 
shares issuable under the Plan is adopted by the Board prior to the initial 
grant of any such option and within one year thereafter such amendment is 
approved by the Company's stockholders, if such stockholder approval is deemed 
necessary by the Board, and (ii) each option granted is not to become 
exercisable, in whole or in part, at any time prior to the obtaining of such 
stockholder approval, and provided further that at any time that the Amended 
and Restated Governance Agreement dated as of October 25, 1995 between the 
Company and Roche Holdings, Inc. (the "Amended Governance Agreement") remains 
in effect, any action by the Board pursuant to the foregoing shall require the 
approval of a majority of the Independent Directors (as such term is defined 
in Article Eleventh of the Certificate of Incorporation of the Company).

IV.  MISCELLANEOUS PROVISIONS

  A. Any cash proceeds received by the Company from the issuance of shares 
hereunder shall be used for general corporate purposes.

  B. The implementation of the Plan, the granting of any stock option 
hereunder, and the issuance of Special Common Stock under the Option Grant 
Program or the Automatic Grant Program, shall be subject to the Company's 
procurement of all approvals and permits required by regulatory authorities 
having jurisdiction over the Plan, the stock options granted under it and the 
Special Common Stock issued pursuant to it.

  C. Neither the action of the Company in establishing the Plan, nor any 
action taken by the Board or the Committee hereunder, nor any provision of the 
Plan itself shall be construed so as to grant any individual the right to 
remain in the employ or service of the Company or any of its Parent or 
Subsidiaries for any period of specific duration, and the Company (or any 
parent or subsidiary retaining the services of such individual) may terminate 
such individual's employment or service at any time and for any reason, with 
or without cause.

  D. Nothing contained in the Plan shall be construed to limit the authority 
of the Company to exercise its corporate rights and powers, including (without 
limitation) the right of the Company (a) to grant options for proper corporate 
purposes otherwise than under this Plan to any Employee or other person, firm 
or company or association or (b) to grant options to, or assume the option of, 
any person in connection with the acquisition (by purchase, lease, merger, 
consolidation or otherwise) of the business and assets (in whole or in part) 
of any person, firm, company or association.

                                 ARTICLE FIVE

                       SPECIAL REDEMPTION PROVISIONS

I.  PRIORITY

  To the extent there is a conflict between any of the provisions of this 
Article Five and any other provision of the Plan, the specific provisions of 
this Article Five shall be controlling and shall govern the disposition of all 
such options outstanding at the time the Redemption (as defined below) occurs 
or no longer can occur.

II.  EFFECT OF REDEMPTION ON VESTED OPTIONS

  A. If the Special Common Stock shall be redeemed at any time as provided in 
Section (c)(ii) of Article Third of the Certificate of Incorporation of the 
Company (the "Redemption"), then holders of all outstanding options granted 
hereunder, to the extent vested immediately prior to the date fixed for the 
Redemption ("Vested Options"), shall promptly be paid for each such Vested 
Option or right an amount equal to the product of (i) the excess of the 
redemption price per share fixed in Section (c)(ii) of Article Third (without 
reduction for the payment of any cash dividends as provided in the fourth 
sentence of Section (c)(ii)(C) of Article Third) over the exercise price per 
share, times (ii) the number of shares covered by such Vested Option or right.

III.  EFFECT OF REDEMPTION ON UNVESTED OPTIONS

  A. Upon the Redemption, each option granted under this Plan, to the extent 
not vested immediately prior to the date fixed for the Redemption, shall be 
replaced by a comparable incentive program. Each such continuing option will 
become exercisable, and the shares purchasable thereunder shall vest, in 
accordance with the same installment dates such option would have become 
exercisable, and such shares would have vested, under the vesting schedule 
specified for that option at the time of grant.

IV.  EFFECT OF NO REDEMPTION

  A. If the Redemption does not occur, upon conversion of the Special Common 
Stock into Common Stock, each option granted under this Plan prior to such 
conversion shall remain in effect after such conversion upon the same terms 
and conditions (including, without limitation, the exercise price per share 
and the number of shares) in effect for such option immediately prior to such 
conversion, except that the shares purchasable under each such continuing 
option shall be shares of Common Stock. Each such continuing option will 
become exercisable, and the shares purchasable thereunder shall vest, in 
accordance with the same installment dates such option would have become 
exercisable, specified for that option at the time of grant.

V.  OTHER

  A. After the earlier of the Redemption or the Conversion Date (as defined in 
Article Third of the Certificate of Incorporation of the Company), all 
references in the Plan to Special Common Stock shall automatically become 
references to Common Stock.

  B. The exercise by Roche Holdings, Inc. or its affiliates of its right to 
designate nominees to the Board of Directors pursuant to Sections 3.01 and 
3.02 of the Amended Governance Agreement shall not constitute a Change in 
Control.


                      1996 STOCK OPTION/STOCK INCENTIVE PLAN
                      (as amended effective October 16, 1996)

                                   ARTICLE ONE

                                GENERAL PROVISIONS

I.  PURPOSES OF THE PLAN

A.  This 1996 Stock Option/Stock Incentive Plan (the "Plan") is intended to 
promote the interests of Genentech, Inc., a Delaware corporation (the 
"Company"), by providing a method whereby the Company may retain the services 
of persons now employed by or serving as consultants or directors to it, 
secure and retain the services of persons capable of filling such positions 
and provide incentives for such persons to exert maximum efforts for the 
success of the Company or its parent or subsidiary corporations.

B.  For purposes of the Plan, the following definitions shall be in effect:

  CHANGE IN CONTROL: "Change in Control" shall have the meaning set forth in 
Article Two, III.C. hereof.

  CHANGE IN CONTROL PRICE: "Change in Control Price" shall have the meaning 
set forth in Article Two, II.C.4.b. hereof.

  CLOSING SELLING PRICE: The Closing Selling Price per share of Special Common 
Stock on any relevant date under the Plan shall be the closing selling price 
per share of Special Common Stock, if such Special Common Stock is reported on 
a national securities exchange or reported on the NASDAQ National Market 
System (or any successor system), for the trading day immediately preceding 
the date in question, as such price is published in the Wall Street Journal 
(or if such publication is not available, a comparable publication selected by 
the Committee).

  CONSULTANT: An individual shall be considered to be a Consultant for so long 
as such individual continues to render personal services to the Company or one 
or more of its Parent or Subsidiaries as an independent contractor or 
continues to have an effective and unexpired consulting agreement with the 
Company.

  CORPORATE TRANSACTION: "Corporate Transaction" shall have the meaning set 
forth in Article Two, III.A. hereof.

  EMPLOYEE: An individual shall be considered to be an Employee for so long as 
such individual remains in the employ of the Company or one or more of its 
Parent or Subsidiaries, irrespective of whether employment services are 
actually provided by the individual.

  PARENT: A corporation shall be deemed to be a parent of the Company if it is 
a corporation (other than the Company) in an unbroken chain of corporations 
ending with the Company, provided each such corporation in the unbroken chain 
(other than the Company) owns, at the time of the determination, stock 
possessing fifty percent (50%) or more of the total combined voting power of 
all classes of stock in one of the other corporations in such chain.

  SECTION 16(b) INSIDER: An individual shall be considered to be a Section 
16(b) Insider on any relevant date under the Plan if such individual (A) is at 
the time an officer or director of the Company subject to the short-swing 
profit restrictions of the regulations promulgated under Section 16 of the 
Securities Exchange Act of 1934, as amended (the "1934 Act") or (B) unless 
Section 16 or regulations promulgated thereunder, are amended to provide 
otherwise, was such an officer or director at any time during the six month 
period immediately preceding the date in question and made any purchase or 
sale of Special Common Stock during such six-month period.

  SERVICE: An individual shall be deemed to be in the Service of the Company 
for so long as such individual renders service on a periodic basis to the 
Company or one or more of its Parent or Subsidiaries as an Employee or 
Consultant.

  SPECIAL COMMON STOCK: The Special Common Stock issuable under the Plan shall 
be shares of the Company's Callable Putable Common Stock, par value $0.02 per 
share. All references to "shares" or "stock", shall be deemed to be references 
to shares of the Special Common Stock.

  SUBSIDIARY: A corporation shall be deemed to be a subsidiary of the Company 
if it is one of the corporations (other than the Company) in an unbroken chain 
of corporations beginning with the Company, provided each such corporation 
(other than the last corporation in the unbroken chain) owns, at the time of 
determination, stock possessing 50 percent or more of the total combined 
voting power of all classes of stock in one of the other corporations in such 
chain. For purposes of non-statutory option grants under Article Two and stock 
incentive grants under Article Four and all Corporate Transaction provisions 
of the Plan, the term "subsidiary" shall also include any partnership, joint 
venture or other business entity of which the Company owns, directly or 
indirectly through another subsidiary corporation, more than a fifty percent 
(50%) interest in voting power, capital or profits.

C.  Neither stock option grants nor stock bonus issuances made to any 
individual under the Plan shall in any way affect, limit or restrict such 
individual's eligibility to participate in any other stock plan or other 
compensation or benefit plan, arrangement or practice now or hereafter 
maintained by the Company or any Parent or Subsidiary.

II.  ADMINISTRATION OF THE PLAN

A.  The Plan shall be administered by the Compensation Committee (the 
"Committee").  The Committee shall be comprised of not less than two (2) Board 
members.  The Board may from time to time appoint members to the Committee in 
substitution for (or in addition to) members previously appointed, and the 
Board shall have the authority to fill any and all vacancies on the Committee, 
however caused.

B.  Subject to limitations contained elsewhere herein and to the provisions of 
Section V., C. and D. of this Article I relating to adjustments upon changes 
in stock, the aggregate number of shares of stock that may be subject to 
options and stock appreciation rights granted hereunder to any Employee in a 
calendar year shall not exceed two hundred fifty thousand (250,000) shares of 
the Company's Special Common Stock.

C.  Subject to the express provisions of the Plan, the Committee shall have 
plenary authority:

  (i) to interpret the Plan, to prescribe, amend and rescind rules and 
regulations relating to it, and to make all other determinations deemed 
necessary or advisable in administering the Plan; and

  (ii) to change the terms and conditions of any outstanding discretionary 
option grant or unvested stock issuance, provided such action does not, 
without the consent of the holder, adversely affect the rights and obligations 
such individual may have under the Plan or the outstanding grant or stock 
issuance.

D.  Determinations of the Committee on all matters relating to the Plan and 
any discretionary option grants or stock issuances made hereunder shall be 
final, binding and conclusive on all persons having any interest in the Plan 
or any options granted or shares issued under the Plan.

III.  STRUCTURE OF THE PLAN

A.  The Plan shall be divided into three separate components: the Regular 
Option Grant Program specified in Article Two, the Automatic Grant Program 
specified in Article Three and the Stock Incentive Program specified in 
Article Four.  Under the Regular Option Grant Program, eligible Employees, 
non-Employee Board members and Consultants may be granted options to purchase 
shares of Special Common Stock at an exercise price equal to not less than 50% 
of the Closing Selling Price per share on the grant date. Under the Automatic 
Grant Program, non-Employee Board members shall automatically be granted 
options to purchase shares of Special Common Stock on the dates and in the 
amounts specified in Article Three below at an exercise price of 100% of the 
Closing Selling Price per share of Special Common Stock on the date of grant.

B.  Under the Stock Incentive Program, eligible Employees, non-Employee Board 
members and Consultants may be awarded shares of Special Common Stock as a 
reward for past services or as an incentive to the performance of future 
services. Such shares may be issued as fully-vested shares or as shares 
vesting over time.

C.  The provisions of Articles One, Five and Six of the Plan shall apply to 
the Regular Option Grant Program, the Automatic Option Grant Program and the 
Stock Incentive Program and shall accordingly govern the interests of all 
individuals in the Plan.

IV.  ELIGIBILITY FOR OPTION GRANTS AND STOCK ISSUANCES

A.  The individuals eligible to receive option grants ("Optionees") and/or 
stock incentives ("Recipients") pursuant to the Plan shall be limited to (i) 
those Employees, non-Employee Board members and Consultants selected by the 
Committee and (ii) those non-Employee Board members who are entitled to option 
grants pursuant to the Automatic Option Grant Program of Article Three. 

V.  STOCK SUBJECT TO THE PLAN

A.  The Special Common Stock issuable under the Plan shall be made available 
either from authorized but unissued shares of Special Common Stock or from 
shares of Special Common Stock reacquired by the Company on the open market. 
The aggregate number of shares of Special Common Stock issuable over the term 
of this Plan, whether through exercised options or direct stock issuances 
shall not exceed 9,000,000 shares (subject to adjustment from time to time in 
accordance with paragraphs C. and D. below).

B.  Should an option granted under this Plan expire or terminate for any 
reason prior to exercise or surrender in full (including options canceled in 
accordance with the cancellation-regrant provisions of the Regular Option 
Grant Program), the shares subject to the portion of the option not so 
exercised or surrendered shall be available for subsequent option grants under 
this Plan. Shares subject to stock appreciation rights exercised in accordance 
with the Stock Appreciation Right provisions of Article Two and shares 
repurchased by the Company pursuant to its repurchase rights under the Plan 
shall not be available for subsequent issuance, whether through option grants, 
stock appreciation rights or direct issuances, under this Plan.

C.  In the event any change is made to the Special Common Stock issuable under 
the Plan by reason of any stock dividend, stock split, combination of shares, 
exchange of shares or other change affecting the outstanding Special Common 
Stock as a class without receipt of consideration, then appropriate 
adjustments shall be made by the Committee to (i) the aggregate number and/or 
class of shares issuable under this Plan, the maximum number and/or class of 
shares purchasable per Employee pursuant to the applicable limitation of 
Section II.B of this Article One and the number and/or class of shares for 
which the automatic option grants are to be made pursuant to the provisions of 
Article Three, to reflect the effect of such change upon the Company's capital 
structure, (ii) the number and/or class of shares and the exercise price per 
share of the stock subject to each outstanding option in order to preclude the 
dilution or enlargement of benefits thereunder and (iii) the number and/or 
class of shares and the exercise price per share in effect under each 
outstanding stock appreciation right in order to preclude the dilution or 
enlargement of benefits thereunder. All adjustments made by the Committee 
pursuant to this paragraph C. shall be final, binding and conclusive.

D.  Subject to the special priority provisions of Article Six of the Plan, in 
the event that (i) the Company is the surviving entity in any Corporate 
Transaction that does not result in the termination of outstanding options 
pursuant to the Corporate Transaction provisions of the Plan or (ii) the 
outstanding options under the Plan are to be assumed in connection with such 
Corporate Transaction, then each such continuing or assumed option shall, 
immediately after such Corporate Transaction, be appropriately adjusted to 
apply and pertain to the number and class of securities which would be 
issuable, in consummation of such Corporate Transaction, to an actual holder 
of the same number of shares of Special Common Stock as are subject to such 
option immediately prior to such Corporate Transaction. Appropriate 
adjustments shall also be made to the exercise price payable per share subject 
to each option, provided that the aggregate exercise price of such option 
shall remain the same. In addition, the aggregate number and/or class of 
shares issuable under this Plan shall be appropriately adjusted to reflect the 
effect of such Corporate Transaction upon the Company's capital structure.

                                  ARTICLE TWO

REGULAR OPTION GRANT PROGRAM

I.  TERMS AND CONDITIONS OF OPTIONS

A.  The Committee shall have plenary authority (subject to the express 
provisions of the Plan and Section 144 of the Delaware General Corporation 
Law) to determine which Employees, non-Employee Board members and Consultants 
are to be granted options under this Regular Option Grant Program, the number 
of shares to be covered by each such option, the status of the granted option 
as either an incentive stock option ("Incentive Option") which meets the 
requirements of Section 422 of the Internal Revenue Code of 1986, as amended 
from time to time (the "Code"), or a non-statutory option not intended to meet 
such requirements, the time or times at which such option is to become 
exercisable, the time or times at which such option (or the Shares subject to 
such option) becomes vested (referred to herein as the "vesting schedule") and 
the term for which the option is to remain outstanding, up to a maximum term 
of ten (10) years.

B.  The granted options shall be evidenced by instruments in such form as the 
Committee shall from time to time approve; provided, however, that each such 
instrument shall comply with and incorporate the terms and conditions 
specified below, except as such terms and conditions must be modified for 
Incentive Options as set forth below in Section IV of this Article Two.

      1.  Exercise Price.

  a.  The exercise price per share shall be fixed by the Committee, but in no 
event shall the exercise price per share be less than fifty percent (50%) of 
the Closing Selling Price per share of Special Common Stock on the date of the 
option grant.

  b.  The exercise price shall become immediately due upon exercise of the 
option and shall, subject to the loan provisions of this Article Two, be 
payable in one of the alternative forms specified below:

     (A) full payment in cash or check made payable to the Company's order; or

     (B) full payment in shares of Special Common Stock held by the Optionee 
for the requisite period necessary to avoid a charge to the Company's reported 
earnings and valued at the Closing Selling Price on the Exercise Date (as such 
term is defined below); or

     (C) full payment in a combination of shares of Special Common Stock held 
by the Optionee for the requisite period necessary to avoid a charge to the 
Company's reported earnings and valued at the Closing Selling Price on the 
Exercise Date and cash or check.

  c.  For purposes of subparagraph b. above, the Exercise Date shall be the 
first date on which there is delivered to the Company both (i) written notice 
of the exercise of the option and (ii) payment of the exercise price for the 
purchased shares.

     2.  Term and Exercise of Options.

  a.  Each option granted under this Regular Option Grant Program shall be 
exercisable in one or more installments over the Optionee's period of Service 
as shall be determined by the Committee and set forth in the instrument 
evidencing such option; provided, however, that no such option granted to a 
Section 16(b) Insider shall become exercisable in whole or in part within the 
first six (6) months after the grant date, except in the event of the 
Optionee's death or disability.

  b.  An option may be exercisable by the Optionee or, in the event the 
Optionee is permanently disabled (as such term is defined in Section 22(e) of 
the Code), by his or her spouse, and such option may be transferred by the 
Optionee to a trust for such Optionee's benefit or the benefit of an immediate 
family member or by will or the laws of descent or distribution.

  c.  The Committee may, at its discretion, accelerate the vesting schedule of 
any outstanding option at any time.

     3.  Termination of Service.

  a.  Should an Optionee cease to continue in Service for any reason (other 
than termination due to death, permanent disability or retirement from 
employment by the Company after reaching age sixty-five (65)) while the holder 
of one or more outstanding options under this Regular Option Grant Program, 
then such options shall not be exercisable at any time after the earlier of 
(i) the specified expiration date of the option term or (ii) the expiration of 
three (3) months after the Optionee's cessation of Service. Each such option 
shall, during the applicable period following cessation of Service, be 
exercisable only to the extent of the number of shares (if any) in which the 
Optionee is vested on the date of such cessation of Service; provided, 
however, that the Committee shall have the discretion to specify, either at 
the time the option is granted or at the time that the Optionee ceases 
Service, that vesting of such option may be extended for a period not to 
exceed three (3) years from the date of cessation of Service and that the 
applicable expiration period set forth in clause (ii) may be increased to a 
period of up to five (5) years.

  b.  Should an Optionee cease to continue in Service due to permanent 
disability while the holder of one or more outstanding options under this 
Regular Option Grant Program, then such options shall not be exercisable at 
any time after the earlier of (i) the specified expiration date of the option 
term or (ii) the expiration of three (3) months after the Optionee's cessation 
of Service. Each such option shall, during the applicable period following 
cessation of Service, be exercisable only to the extent of the number of 
shares (if any) in which the Optionee is vested on the date of such cessation 
of Service; provided, however, that the Committee shall have the discretion to 
specify, either at the time the option is granted or at the time that the 
Optionee ceases Service, that the vesting of such option may be accelerated or 
extended from the date of cessation of Service and that the period of 
exercisability can be increased up to the expiration date of the option term.  
Should an Optionee cease to continue in Service due to death, or retirement 
from employment by the Company after reaching age sixty-five (65), while the 
holder of one or more outstanding options under this Regular Option Grant 
Program, then all unvested options on such date shall automatically become 
vested and the expiration date of the option shall automatically be extended 
to the expiration date of the option term.

  c.  Any option granted to an Optionee under this Regular Option Grant 
Program and outstanding in whole or in part on the date of the Optionee's 
death may be subsequently exercised by the personal representative of the 
Optionee's estate or by the person or persons to whom the option is 
transferred pursuant to the Optionee's will or in accordance with the laws of 
descent and distribution in the case of the Optionee's death, and any option 
granted to an Optionee under this Regular Option Grant Program which is 
outstanding in whole or in part on the date of the Optionee's cessation of 
Service due to permanent disability may be exercised by the Optionee's spouse 
or designee. Any such exercise must be in accordance with subparagraph b.

  d.  The Committee shall have complete discretion, exercisable either at the 
time the option is granted or at the time the Optionee ceases Service, to 
establish as a provision applicable to the exercise of one or more options 
granted under this Regular Option Grant Program that during the limited period 
of exercisability following cessation of Service due to retirement, "plant 
closing" or "mass layoff" (as such terms are defined at 29 U.S.C. Section 
2101) that is subject to the notice requirements of 29 U.S.C. Section 2102, 
the option will continue to vest according to the vesting schedule that would 
have applied had the optionee continued in Service.

     4.  Repurchase Rights.

  a.  Options may provide that notwithstanding any vesting schedule pursuant 
to subparagraph 2. a. above, they may be exercised prior to such vesting 
schedule so long as the Optionee enters into a repurchase agreement 
satisfactory to the Company.  The shares of Special Common Stock acquired upon 
the exercise of one or more options granted under this Regular Option Grant 
Program may be subject to repurchase by the Company, at the exercise price 
paid per share, upon the Optionee's cessation of Service prior to vesting in 
such shares.

  b.  Any such repurchase right shall be exercisable by the Company upon such 
terms and conditions (including the establishment of the appropriate vesting 
schedule and other provision for the expiration of such right in one or more 
installments over the optionee's period of Service) as the Committee may 
specify in the instrument evidencing such right, which instrument shall 
include appropriate terms with respect to the legending of stock certificates 
and the placing of unvested shares into escrow.

  c.  All of the Company's outstanding repurchase rights shall automatically 
terminate, and all shares purchased under this Regular Option Grant Program 
shall immediately vest in full, upon the occurrence of any Corporate 
Transaction or Change in Control; provided, however, that no such termination 
of repurchase rights or immediate vesting of the purchased shares shall occur 
if (and to the extent that): (i) the Company's outstanding repurchase rights 
are to be assigned to the successor corporation (or parent thereof) in 
connection with the Corporate Transaction or (ii) such termination of 
repurchase rights and acceleration of vesting are precluded by other 
limitations imposed by the Committee either at the time the option is granted 
or at the time the option shares are purchased.

     5.  Stockholder Rights.

An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by the option until such individual shall have exercised 
the option, paid the option price and satisfied all other conditions precedent 
to the issuance of certificates for the purchased shares.

II. STOCK APPRECIATION RIGHTS

A.  The Committee shall have full power and authority, exercisable in its sole 
discretion, to grant stock appreciation rights to one or more Employees, non-
Employee Board members or Consultants eligible for option grants under this 
Regular Option Grant Program. Each such right shall entitle the holder to a 
distribution based on the appreciation in the value per share of a designated 
amount of Special Common Stock.

B.  Three types of stock appreciation rights shall be authorized for issuance 
under the Plan:

  1.  Tandem Stock Appreciation Rights.  These rights require the holder to 
elect between the exercise of the underlying option for shares of Special 
Common Stock and the surrender of such option for an appreciation distribution 
equal to the excess of (i) the Closing Selling Price (on the date of option 
surrender) of the vested shares of Special Common Stock purchasable under the 
surrendered option over (ii) the aggregate option price payable for such 
shares.

  2.  Concurrent Stock Appreciation Rights.  Concurrent rights may apply to 
all or any portion of the shares of Special Common Stock subject to the 
underlying option and will be exercised automatically at the same time the 
option is exercised for those shares. The appreciation distribution to which 
the holder of such concurrent right shall be entitled upon exercise of the 
underlying option shall be in an amount equal to the excess of (i) the 
aggregate Closing Selling Price (at date of exercise) of the vested shares 
purchased under the underlying option with such concurrent rights over (ii) 
the aggregate option price paid for those shares.

  3.  Limited Stock Appreciation Rights.  These rights will entitle the holder 
to surrender outstanding options in connection with certain Changes in Control 
(as defined below) for an appreciation distribution equal in amount to the 
excess of (i) the Change in Control Price (as defined below) of the number of 
shares in which the Optionee is at the time vested under the surrendered 
option over (ii) the aggregate option price payable for such vested shares.

C.  The terms and conditions applicable to each Tandem Stock Appreciation 
Right ("Tandem Right"), Concurrent Stock Appreciation Right ("Concurrent 
Right") and Limited Stock Appreciation Right ("Limited Right") shall be as 
follows:

     1.  Tandem Rights.

  a.  Tandem Rights may be tied to either Incentive Options or non-statutory 
options. Each such right shall, except as specifically set forth below, be 
subject to the same terms and conditions applicable to the particular stock 
option grant to which it pertains.

  b.  The Appreciation Distribution payable on the exercised Tandem Right 
shall be in an amount equal to the excess of (i) the Closing Selling Price (on 
the date of the option surrender) of the number of shares of Special Common 
Stock in which the Optionee is vested under the surrendered option over (ii) 
the aggregate option price payable for such vested shares.

  c.  The Appreciation Distribution may, in the Committee's discretion, be 
made in cash, in shares of Special Common Stock or in a combination of cash 
and Special Common Stock. Any shares of Special Common Stock so distributed 
shall be valued at the Closing Selling Price on the date the option is 
surrendered, and the shares of Special Common Stock subject to the surrendered 
option shall not be available for subsequent issuance under this Plan.

     2.  Concurrent Rights.

  a.  Concurrent Rights may be tied to any or all of the shares of Special 
Common Stock subject to any Incentive Option or non-statutory option grant 
made under this Regular Option Grant Program. The Concurrent Right shall, 
except as specifically set forth below, be subject to the same terms and 
conditions applicable to the particular stock option grant to which it 
pertains.

  b.  The Concurrent Right shall be automatically exercised at the same time 
the underlying option is exercised for the particular shares of Special Common 
Stock to which the Concurrent Right pertains.

  c.  The Appreciation Distribution payable on the exercised Concurrent Right 
shall be equal to the excess of (i) the aggregate Closing Selling Price (on 
the Exercise Date) of the vested shares of Special Common Stock purchased 
under the underlying option which have Concurrent Rights appurtenant to them 
over (ii) the aggregate option price paid for such shares.

  d.  The Appreciation Distribution may, in the Committee's discretion, be 
paid in cash, in shares of Special Common Stock or in a combination of cash 
and Special Common Stock. Any shares of Special Common Stock so distributed 
shall be valued at the Closing Selling Price on the date the Concurrent Right 
is exercised and shall reduce on a one-for-one basis the number of shares of 
Special Common Stock thereafter issuable under this Plan.

     3.  Terms Applicable to Both Tandem Rights and Concurrent Rights.

  a.  To exercise any outstanding Tandem or Concurrent Right, the holder must 
provide written notice of exercise to the Company in compliance with the 
provisions of the instrument evidencing such right.

  b.  If a Tandem or Concurrent Right is granted to an individual who is at 
the time a Section 16(b) Insider, then the instrument of grant shall 
incorporate all the terms and conditions at the time necessary to assure that 
the subsequent exercise of such right shall qualify for the safe-harbor 
exemption from short-swing profit liability provided by SEC Rule 16b-3 (or any 
successor rule or regulation).

  c.  No limitation shall exist on the aggregate amount of cash payments the 
Company may make under this Article Two Program in connection with the 
exercise of Tandem or Concurrent Rights.

     4.  Limited Rights.

  a.  Each Section 16(b) Insider shall have the Limited Right, exercisable in 
the event there should occur a Change in Control (as such term is defined 
below), to surrender any or all of the options (whether incentive stock 
options or non-statutory options) held by such individual under this Article 
Two Program, to the extent such options (i) have been outstanding for at least 
six (6) months and (ii) are at the time exercisable for vested shares.

  b.  In exchange for each option surrendered in accordance with subparagraph 
a. above, the Section 16(b) Insider shall receive an Appreciation Distribution 
in an amount equal to the excess of (i) the Change in Control Price 
(determined as of the date of surrender) of the number of shares in which the 
Section 16(b) Insider is at the time vested under the surrendered option over 
(ii) the aggregate option price payable for such vested shares. For purposes 
of such Appreciation Distribution, the Change in Control Price per share of 
the vested Special Common Stock subject to the surrendered option shall be 
deemed to be equal to the greater of (a) the Closing Selling Price per share 
on the date of surrender or (b) the highest reported price per share paid in 
effecting the Change in Control. However, if the option is an Incentive 
Option, then the Change in Control Price of the vested shares subject to the 
surrendered option shall not exceed the value per share determined under 
clause (a) above.

  c.  The Appreciation Distribution shall be made entirely in cash, and the 
shares of Special Common Stock subject to each surrendered option shall not be 
available for subsequent issuance under this Plan.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL

A.  In the event of any of the following transactions (a "Corporate 
Transaction"):

  (i) a merger or acquisition in which the Company is not the surviving 
entity, except for a transaction the principal purpose of which is to change 
the State of the Company's incorporation,

  (ii) the sale, transfer or other disposition of all or substantially all of 
the assets of the Company to any entity other than a Subsidiary of the 
Company, or

  (iii) any reverse merger in which the Company is the surviving entity but in 
which fifty percent (50%) or more of the Company's outstanding voting stock 
held by persons who are not "Subject Persons" as defined in Article Eleventh 
of the Company's Certificate of Incorporation (as in effect on September 7, 
1990) including persons included in such definition by subparagraph (b) 
thereof is transferred to holders different from those who held the stock 
immediately prior to such merger, then the exercisability of each option 
outstanding under this Regular Option Grant Program shall be automatically 
accelerated so that each such option shall, immediately prior to the specified 
effective date for the Corporate Transaction, become fully exercisable with 
respect to the total number of shares of Special Common Stock purchasable 
under such option and may be exercised for all or any portion of such shares. 
However, an outstanding option under this Regular Option Grant Program shall 
not be so accelerated if and to the extent: (i) such option is, in connection 
with the Corporate Transaction, either to be assumed by the successor 
corporation or parent thereof or be replaced with a comparable option to 
purchase shares of the capital stock of the successor corporation or parent 
thereof, or (ii) such option is to be replaced by a comparable cash incentive 
program of the successor corporation based on the value of the option at the 
time of the Corporate Transaction, or (iii) the acceleration of such option is 
subject to other applicable limitations imposed by the Committee at the time 
of grant. The determination of comparability under clause (i) or (ii) above 
shall be made by the Committee, and its determination shall be final, binding 
and conclusive.

B.  Upon the consummation of the Corporate Transaction, all outstanding 
options under this Regular Option Grant Program shall, to the extent not 
previously exercised or assumed by the successor corporation or its parent 
company, terminate and cease to be outstanding.

C.  In the event of any of the following transactions (a "Change in Control"):

  (i) the acquisition by a person or group of related persons, other than the 
Company or any person controlling, controlled by or under common control with 
the Company, of beneficial ownership (as determined pursuant to the provisions 
of Rule 13d-3 under the 1934 Act) of securities of the Company representing 
thirty percent (30%) or more of the combined voting power of the Company's 
then outstanding securities pursuant to a transaction or series of related 
transactions which the Board does not approve; or

  (ii) the first date within any period of thirty-six (36) consecutive months 
or less on which there is effected any change in the composition of the Board 
such that the majority of the Board (determined by rounding up to the next 
whole number) ceases to be comprised of individuals who either (I) have been 
members of the Board continuously since the beginning of such period or (II) 
have been elected or nominated for election as Board members during such 
period by at least a majority of the Board members described in clause (I) who 
were still in office at the time such election or nomination was approved by 
the Board; then the exercisability of each option outstanding under this 
Regular Option Grant Program shall be automatically accelerated so that each 
such option shall become exercisable, immediately prior to such Change in 
Control, for the full number of shares purchasable under such option and may 
be exercised for all or any portion of such shares. However, an outstanding 
option under this Regular Option Grant Program shall not be so accelerated if 
and to the extent one or more limitations imposed by the Committee at the time 
of grant preclude such acceleration upon a Change in Control.

D.  The grant of options under this Regular Option Grant Program shall in no 
way affect the right of the Company to adjust, reclassify, reorganize or 
otherwise change its capital or business structure or to merge, consolidate, 
dissolve, liquidate or sell or transfer all or any part of its business or 
assets.

IV. INCENTIVE OPTIONS

A.  The terms and conditions specified below shall be applicable to all 
Incentive Options granted under this Regular Option Grant Program. Options 
which are specifically designated as "non-statutory" options when issued under 
this Regular Option Grant Program shall not be subject to such terms and 
conditions.

     1.  Option Price.

  The option price per share of the Special Common Stock subject to an 
Incentive Option shall in no event be less than one hundred percent (100%) of 
the Closing Selling Price per share of Special Common Stock on the grant date.

     2.  10% Stockholder.

  If any individual to whom an Incentive Option is to be granted pursuant to 
the provisions of this Regular Option Grant Program is on the grant date the 
owner of stock (as determined under Section 424(d) of the Internal Revenue 
Code) possessing 10% or more of the total combined voting power of all classes 
of stock of the Company or any one of its Parent or Subsidiaries (such person 
to be herein referred to as a 10% Stockholder), then (i) the option price per 
share shall not be less than one hundred and ten percent (110%) of the Closing 
Selling Price per share of Special Common Stock on the grant date and (ii) the 
maximum term of the option shall not exceed five (5) years from the grant 
date.

     3.  Dollar Limitation.

  The aggregate fair market value (determined on the basis of the Closing 
Selling Price in effect on the respective date or dates of grant) of the 
Special Common Stock for which one or more options granted to any Employee 
under this Plan (or any other option plan of the Company or its Parent or 
Subsidiaries) may for the first time become exercisable as incentive stock 
options under the Federal tax laws during any one calendar year shall not 
exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the 
Employee holds two or more such options which become exercisable for the first 
time in the same calendar year, the foregoing limitation on the exercisability 
thereof as incentive stock options under the Federal tax laws shall be applied 
on the basis of the order in which such options are granted.

     4.  Term and Exercise of Options.

  a.  No Incentive Option shall have a term in excess of ten (10) years from 
the grant date.

  b.  An Incentive Option shall not be transferable except by will or by the 
laws of descent and distribution and shall be exercisable during the lifetime 
of the Optionee only by the Optionee.

     5.  Termination of Service.

  A.  Notwithstanding any terms in the Plan to the contrary, an Incentive 
Option must be exercised within the three (3) month period commencing with the 
date of cessation of Employee status for any reason, except that in the event 
the Optionee's cessation of Employee status is due to permanent disability, 
such period shall be one (1) year from the date of such cessation of Employee 
status. Incentive Options not exercised within the applicable period shall be 
treated as non-statutory options.

  B.  Except as modified by the preceding provisions of this Incentive Options 
section, all the provisions of this Regular Option Grant Program shall be 
applicable to the Incentive Options granted hereunder.  If any option 
originally granted as an Incentive Stock Option is modified so as not 
to qualify under the Code as an Incentive Stock Option, such modified 
Incentive Stock Option shall be a non-statutory option.

V.  CANCELLATION AND RE-GRANT OF OPTIONS

  The Committee shall have the authority to effect, at any time and from time 
to time, with the consent of the affected option holders, the cancellation of 
any or all outstanding options under this Regular Option Grant Program and to 
grant in substitution therefor new options under this Plan covering the same 
or different numbers of shares of Special Common Stock but having an option 
price per share not less than fifty percent (50%) of the Closing Selling Price 
(one hundred percent (100%) of the Closing Selling Price in the case of an 
Incentive Option or, in the case of a 10% Stockholder, not less than one 
hundred and ten percent (110%) of the Closing Selling Price) per share of 
Special Common Stock on the new grant date.

VI.  LOANS OR GUARANTEE OF LOANS

  The Committee may assist any Employee (including any officer or director) in 
the exercise of one or more options under this Regular Option Grant Program by 
(a) authorizing the extension of a loan to such Employee from the Company, (b) 
permitting the Employee to pay the option price for the purchased Special 
Common Stock in installments over a period of years or (c) authorizing a 
guarantee by the Company of a third-party loan to the Employee. The terms of 
any loan, installment method of payment or guarantee (including the interest 
rate and terms of repayment) shall be established by the Committee in its sole 
discretion. Loans, installment payments and guarantees may be granted without 
security or collateral, but the maximum credit available to the Optionee shall 
not exceed the sum of (i) the aggregate exercise price (less the par value) of 
the purchased shares plus (ii) any Federal and State income and employment tax 
liability incurred by the Employee in connection with the exercise of the 
option.

                                   ARTICLE THREE

                              AUTOMATIC GRANT PROGRAM

I.  AUTOMATIC GRANTS

  On April 30, 1996 each individual who is a non-Employee member of the Board 
on such date shall automatically be granted a non-statutory option under this 
Article Three to purchase 20,000 shares of Special Common Stock.  Each non-
Employee who is first appointed or elected a member of the Board after April 
30, 1996 shall automatically be granted, on the date of such individual's 
election to the Board, a non-statutory option under this Article Three to 
purchase 20,000 shares of Special Common Stock.  Each Employee director who is 
first elected a member of the Board and who subsequently becomes a non-
Employee director after April 30, 1996 shall automatically be granted, on the 
date of such individual's change from Employee to non-Employee director, a 
non-statutory option under this Article Three to purchase 20,000 shares of 
Special Common Stock.

II.  TERMS AND CONDITIONS OF GRANT

  Each option granted in accordance with the provisions of this Article Three 
shall be evidenced by an instrument in such form as the Committee approves 
from time to time for grants made under Article Two; provided, however, that 
each such automatic grant shall be subject to the following terms and 
conditions:

     A.  Exercise Price.

  The exercise price per share shall be one hundred percent (100%) of the 
Closing Selling Price per share of Special Common Stock on the grant date.

     B.  Term and Vesting of Options.

  1.  Except as otherwise specified below, each option shall vest in 
increments of 5,000 shares on the first, second, third and fourth 
anniversaries of the grant date and shall thereafter remain exercisable until 
the expiration or earlier termination of the option term.

  2.  Each granted option shall have a term of ten (10) years measured from 
the grant date.

     C.  Exercise of Option.

  Upon exercise of the option, the option exercise price for the purchased 
shares shall become immediately due and payable in full in one of the 
alternative forms specified below:

  (i) cash or check payable to the Company's order;

  (ii) shares of Special Common Stock held by the optionee for the requisite 
period necessary to avoid a charge to the Company's reported earnings and 
valued at the Closing Selling Price on the date of exercise; or

  (iii) any combination of the foregoing so long as the total payment equals 
the aggregate exercise price for the purchased shares.

     D.  Effect of Termination of Board Membership.

1.  Should an optionee cease to be a member of the Board for any reason (other 
than death) prior to the expiration date of the automatic grant held by the 
optionee under this Article Three, then each such grant shall remain 
exercisable, for any shares of Special Common Stock for which the option is 
exercisable at the time of such cessation of Board membership, for a period 
not to exceed the earlier of (i) the expiration of the three (3) month period 
following the date of such cessation of Board membership or (ii) the specified 
expiration date of the option term.

2.  Should the optionee's membership on the Board cease by reason of death, 
then each outstanding grant held by the optionee under this Article Three may 
be subsequently exercised, for any shares of Special Common Stock for which 
the option is exercisable at the time of the optionee's cessation of Board 
membership, by the personal representative of the optionee's estate or by the 
person or persons to whom the option is transferred pursuant to the optionee's 
will or in accordance with the laws of descent and distribution. Any such 
exercise must, however, occur prior to the earlier of (i) the expiration of 
the twelve (12) month period following the date of the optionee's death or 
(ii) the specified expiration date of the option term.

     E.  Stockholder Rights.

  An option holder shall have none of the rights of a stockholder with respect 
to any shares covered by an option granted under this Article Three until such 
individual shall have exercised the option, paid the option exercise price in 
full and satisfied all other conditions precedent to the issuance of 
certificates for the purchased shares.

III.  CORPORATE TRANSACTION

  In the event of a Corporate Transaction, options granted under the Automatic 
Grant Program shall be treated as described in Section III of Article Two, 
except the provisions of clause (iii) of the penultimate sentence of Section 
III A.(iii) of Article Two shall not apply.

IV.  CHANGE IN CONTROL

  In the event of a Change in Control, options granted under the Automatic 
Grant Program shall be treated as described in Section III of Article Two, 
except the last sentence of Section III C.(ii) of Article Two shall not apply.

                                  ARTICLE FOUR

                             STOCK INCENTIVE PROGRAM

I.  TERMS AND CONDITIONS OF STOCK ISSUANCES

A.  Shares may be issued under this Stock Incentive Program as a reward for 
past services rendered the Company or one or more of its Parent or 
Subsidiaries or as an incentive for future service with such entities. Any 
unvested shares so issued shall be evidenced by a Restricted Stock Issuance 
Agreement ("Issuance Agreement") which complies with the terms and conditions 
of this Stock Incentive Program and shall include appropriate terms with 
respect to legending of certificates and escrow of unvested shares.

     1.  Vesting Schedule.

  a.  The Recipient's interest in the issued shares of Special Common Stock 
may, in the absolute discretion of the Committee, be fully and immediately 
vested upon issuance or may vest in one or more installments.

  b.  The elements of the vesting schedule applicable to any unvested shares 
issued under this Stock Incentive Program, namely the number of installments 
in which the shares are to vest, the interval or intervals (if any) which are 
to lapse between installments and the effect which death, disability or other 
event designated by the Committee is to have upon the vesting schedule, shall 
be determined by the Committee and set forth in the Issuance Agreement 
executed by the Company and the Recipient at the time of the incentive grant.

  c.  Except as may otherwise be provided in the Issuance Agreement, the 
Recipient may not transfer unvested shares of Special Common Stock. The 
Recipient, however, shall have all the rights of a stockholder with respect to 
such unvested shares, including without limitation the right to vote such 
shares and to receive all dividends paid on such shares.

     2.  Cancellation of Shares.

  a.  In the event the Recipient should, while his/her interest in the issued 
Special Common Stock remains unvested, cease to continue in Service for any 
reason whatsoever, then the Company shall have the right to cancel all such 
unvested shares, and the Recipient shall thereafter have no further 
stockholder rights with respect to such shares.

  b.  The Committee may in its discretion waive such cancellation of unvested 
shares in whole or in part and thereby effect the immediate vesting of the 
Recipient's interest in the shares of Special Common Stock (or other assets) 
as to which the waiver applies.

     3.  Corporate Transaction/Change in Control.

  All unvested shares under the Stock Incentive Program shall immediately vest 
in full immediately prior to the occurrence of any Corporate Transaction or 
Change in Control, except to the extent:

  (i) the Company's outstanding cancellation rights are to be assigned to the 
successor corporation (or parent thereof) in connection with the Corporate 
Transaction, or

  (ii) one or more limitations imposed by the Committee at the time of stock 
issuance preclude such accelerated vesting.





                                   ARTICLE FIVE

                                   MISCELLANEOUS

I.  TAX WITHHOLDING

A.  The Company's obligation to deliver shares upon the exercise or surrender 
of stock options or stock appreciation rights granted under Article Two or 
Article Three or upon the issuance or vesting of shares under Article Four 
shall be subject to the satisfaction of all applicable Federal, State and 
local income and employment tax withholding requirements.

B.  The Committee may, in its discretion and upon such terms and conditions as 
it may deem appropriate (including the applicable safe-harbor provisions of 
SEC Rule 16b-3 or any successor rule or regulation) provide any or all 
Optionees or Recipients with the election to have the Company withhold, from 
the shares of Special Common Stock purchased or issued under the Plan, one or 
more of such shares with an aggregate Closing Selling Price equal to the 
designated percentage (up to 100% specified by the Optionee or Recipient) of 
the Federal and State income taxes ("Taxes") incurred in connection with the 
acquisition of such shares. In lieu of such direct withholding, one or more 
Optionees or Recipients may also be granted the right to deliver unrestricted 
shares of Special Common Stock to the Company in satisfaction of such Taxes. 
The withheld or delivered shares shall be valued at the Closing Selling Price 
on the applicable determination date for such Taxes.

II.  AMENDMENT OF THE PLAN

A.  The Board shall have the complete and exclusive authority to amend or 
modify the Plan in any or all respects whatsoever; provided, however, that no 
such amendment or modification shall, without the consent of the holders, 
adversely affect rights and obligations with respect to any stock options, 
stock appreciation rights or unvested Special Common Stock at the time 
outstanding under the Plan. In addition, with a view to making available the 
benefits provided by Section 422 of the Code and/or SEC Rule 16b-3 as in 
effect from time to time under the 1934 Act, the Board shall, at the time of 
each such amendment, determine whether or not to submit such amendment of the 
Plan to the Company's stockholders for approval.

B.  No material amendments shall be made to the provisions of the Automatic 
Grant Program without the approval of the Company's stockholders.

III.  EFFECTIVE DATE AND TERM OF PLAN

A.  The Plan shall become effective when adopted by the Board, but no stock 
option or stock appreciation right granted under the Plan shall become 
exercisable, and no shares shall be issued, unless and until the Plan shall 
have been approved by the Company's stockholders. If such stockholder approval 
is not obtained within twelve (12) months after the date of the Board's 
adoption of the Plan, then all stock options and stock appreciation rights 
previously granted under the Plan shall terminate and no further stock options 
or stock appreciation rights shall be granted. Subject to such limitation, the 
Committee may grant stock options and stock appreciation rights under the Plan 
at any time after the effective date and before the date fixed herein for 
termination of the Plan.

B.  The Plan shall in all events terminate on the date determined by the Board 
but in no event shall the Plan terminate later than February 6, 2006. Upon 
such termination, any stock options, stock appreciation rights and unvested 
shares at the time outstanding under the Plan shall continue to have force and 
effect in accordance with the provisions of the instruments evidencing such 
grants or issuances.

C.  Options may be granted under this Plan to purchase shares of Special 
Common Stock in excess of the number of shares then available for issuance 
under the Plan, provided (i) an amendment to increase the maximum number of 
shares issuable under the Plan is adopted by the Board prior to the initial 
grant of any such option and within one year thereafter such amendment is 
approved by the Company's stockholders, if such stockholder approval is deemed 
necessary by the Board, and (ii) each option granted is not to become 
exercisable, in whole or in part, at any time prior to the obtaining of such 
stockholder approval, and provided further that at any time that the Amended 
and Restated Governance Agreement dated as of October 25, 1995 between the 
Company and Roche Holdings, Inc. (the "Amended Governance Agreement") remains 
in effect, any action by the Board pursuant to the foregoing shall require the 
approval of a majority of the Independent Directors (as such term is defined 
in Article Eleventh of the Certificate of Incorporation of the Company).

IV.  MISCELLANEOUS PROVISIONS

A.  Any cash proceeds received by the Company from the issuance of shares 
hereunder shall be used for general corporate purposes.

B.  The implementation of the Plan, the granting of any stock option or stock 
appreciation right hereunder, and the issuance of Special Common Stock under 
the Regular Option Grant, the Automatic Grant Program or Stock Incentive 
Program shall be subject to the Company's procurement of all approvals and 
permits required by regulatory authorities having jurisdiction over the Plan, 
the stock options and stock appreciation rights granted under it and the 
Special Common Stock issued pursuant to it.

C.  Neither the action of the Company in establishing the Plan, nor any action 
taken by the Board or the Committee hereunder, nor any provision of the Plan 
itself shall be construed so as to grant any individual the right to remain in 
the employ or service of the Company or any of its Parent or Subsidiaries for 
any period of specific duration, and the Company (or any parent or subsidiary 
retaining the services of such individual) may terminate such individual's 
employment or service at any time and for any reason, with or without cause.

D.  Nothing contained in the Plan shall be construed to limit the authority of 
the Company to exercise its corporate rights and powers, including (without 
limitation) the right of the Company (a) to grant options for proper corporate 
purposes otherwise than under this Plan to any Employee or other person, firm 
or company or association or (b) to grant options to, or assume the option of, 
any person in connection with the acquisition (by purchase, lease, merger, 
consolidation or otherwise) of the business and assets (in whole or in part) 
of any person, firm, company or association.

                                   ARTICLE SIX

                      SPECIAL REDEMPTION AND PUT PROVISIONS

I.  PRIORITY

  To the extent there is a conflict between any of the provisions of this 
Article Six and any other provision of the Plan, the specific provisions of 
this Article Six shall be controlling and shall govern the disposition of all 
such options outstanding at the time of  the Redemption (as defined below), 
upon the exercise of the Put Rights (as defined below), or when both events 
may no longer occur.  Any rights under Section 1.04 of the Governance 
Agreement dated as of September 7, 1990 between the Company and Roche 
Holdings, Inc., ("Roche") and Section 1.04 of the Amended Governance Agreement 
which a holder of an option, stock appreciation right, or stock issued under 
the Stock Incentive Program may have are superseded in their entirety by this 
Article Six.

II.  EFFECT OF REDEMPTION ON VESTED OPTIONS AND VESTED STOCK APPRECIATION 
RIGHTS AND VESTED SHARES ISSUED UNDER THE STOCK INCENTIVE PROGRAM

A.  If the Special Common Stock shall be redeemed by the Company (the 
"Redemption") at any time as provided in Section (c)(ii) of Article Third of 
the Certificate of Incorporation of the Company as in effect on October 25, 
1995 (the "Certificate") or the put rights are exercisable by the stockholders 
of the Company (the "Put Rights") at any time as provided in Section (c)(iii) 
of Article Third of the Certificate, then holders of all outstanding options 
and stock appreciation rights granted hereunder, to the extent vested 
immediately prior to the date fixed for the Redemption or to the extent to 
which the Put Rights were properly exercised by such holder for their 
outstanding vested options and stock appreciation rights granted hereunder 
("Vested Securities"), shall promptly be paid for such Vested Securities an 
amount equal to the product of (i) the excess of the redemption price or put 
price per share fixed in Section (c)(ii) or (iii) of Article Third of the 
Certificate, as applicable (without reduction for the payment of any cash 
dividends as provided in the fourth sentence of Section (c)(ii)(C) of Article 
Third of the Certificate), over the exercise price per share, times (ii) the 
number of shares covered by such Vested Security.  If either the Redemption or 
exercise of the Put Rights occurs as described in the preceding sentence, then 
holders of all outstanding shares issued under the Stock Incentive Program, to 
the extent vested immediately prior to the date fixed for the Redemption or to 
the extent to which the Put Rights were properly exercised by such holder for 
their outstanding vested shares issued under the Stock Incentive Program 
("Vested Shares"), shall promptly be paid for such Vested Shares an amount 
equal to the product of (i) the redemption price or put price per share fixed 
in Section (c)(ii) or (iii) of Article Third of the Certificate, as applicable 
(without reduction for the payment of any cash dividends as provided in the 
fourth sentence of Section (c)(ii)(C) of Article Third of the Certificate), 
times (ii) the number of Vested Shares.  All payments hereunder shall be 
reduced by any appropriate tax withholding.

III.  EFFECT OF REDEMPTION ON UNVESTED OPTIONS AND STOCK APPRECIATION RIGHTS, 
AND UNVESTED SHARES ISSUED UNDER THE STOCK INCENTIVE PROGRAM

A.  Upon the Redemption each option and stock appreciation right granted under 
this Plan, to the extent not vested immediately prior to the date fixed for 
the Redemption shall be canceled.   Upon the Redemption, all unvested shares 
issued under the Stock Incentive Program shall be canceled.

IV.  EFFECT OF NO REDEMPTION 

A.  If the Redemption does not occur, each option and stock appreciation right 
granted and each share awarded under the Stock Incentive Program under this 
Plan which is outstanding on July 1, 1999 shall remain outstanding on the same 
terms and conditions (including, without limitation, the exercise price per 
share (in the case of options and stock appreciation rights), and the number 
of shares for options, stock appreciation rights and shares issued under the 
Stock Incentive Program) in effect for such option, stock appreciation right 
or share issued under the Stock Incentive Program immediately prior to July 1, 
1999, except that the shares purchasable under each such option, stock 
appreciation right or shares issued under the Stock Incentive Program shall 
continue to be shares of Special Common Stock prior to the Conversion Date (as 
defined in Section (c)(vi) of Article Third of the Certificate) and shares of 
Common Stock on and after the Conversion Date.  Each such continuing option, 
stock appreciation right and share issued under the Stock Incentive Program 
will become exercisable, and shall vest in accordance with the same 
installment dates such option, stock appreciation right or share issued under 
the Stock Incentive Program would have become exercisable at the time of 
grant.  Notwithstanding any provision in this Article Six, Section IV, to the 
contrary, if at any time following July 1, 1999 the shares of Genentech's 
capital stock are no longer listed for trading on the New York Stock Exchange, 
the Nasdaq National Market, or any other national exchange for any reason, any 
unvested options, stock appreciation rights and shares issued under the Stock 
Incentive Program shall automatically be cancelled as of such date.

V.  EXAMPLE

A.  For purposes of this example assume that it is July 1, 1999, the 
Redemption has not occurred, the Put Rights are exercisable, an individual 
holds an option for 100 shares of Special Common Stock with an exercise price 
of $50 per share, 75 of such shares are vested and 25 shares are unvested, the 
Special Common Stock is trading on the New York Stock Exchange at $62 per 
share, and the Put Price (as defined in the Certificate) is $60 per share.  
During the Put Period (as defined in the Certificate) the holder may properly 
exercise the holder's Put Rights with respect to none, some or all of the 75 
vested shares.  If, for example, the holder exercised Put Rights for 40 of the 
75 shares, that holder would receive (40 shares) x (60 - 50 dollars per share) 
= $400, reduced by appropriate tax withholding.  So long as the Special Common 
Stock (during the Put Period) or the Common Stock (following the Put Period) 
are listed for trading on the New York Stock Exchange, the Nasdaq National 
Market, or any other national exchange, (i) the 35 remaining vested shares for 
which Put Rights were not exercised shall remain exercisable to acquire shares 
of Special Common Stock or Common Stock, as appropriate, and (ii) the 25 
unvested shares would continue to vest and, to the extent vested, be 
exercisable to acquire shares of Special Common Stock or Common Stock, as 
appropriate.  If the Special Common Stock or the Common Stock is no longer 
listed for trading on the New York Stock Exchange, the Nasdaq National Market, 
or any other national exchange for any reason, any of the 25 shares that are 
unvested on such date shall automatically be cancelled. 

VI.  OTHER

A.  On the Conversion Date, all references in the Plan to Special Common Stock 
shall automatically become references to Common Stock.

B.  The exercise by Roche Holdings, Inc. or its affiliates of its right to 
designate nominees to the Board of Directors pursuant to Sections 3.01 and 
3.02 of the Amended Governance Agreement shall not constitute a Change in 
Control.


                               GENENTECH, INC.
                         DEFERRED COMPENSATION PLAN


          GENENTECH, INC., a Delaware corporation, hereby adopts the 
Genentech, Inc. Deferred Compensation Plan.  The Plan will become effective 
upon the occurrence of a Redemption or Delisting, whichever shall first occur.

                                 SECTION 1
                               DEFINITIONS

            The following words and phrases shall have the following meanings 
unless a different meaning is plainly required by the context:

            1.1  "Account" or "Account(s)" means as to any Participant the 
separate account(s) maintained on the books of the Company in order to reflect 
his or her interest under the Plan.

            1.2  "Affiliate" means any Parent or Subsidiary of the Company, 
but only for the period during which such other entity actually qualifies as a 
Parent or Subsidiary.

            1.3  "Beneficiary" means the person or persons entitled (under 
Section 5.4) to receive any vested balance credited to a Participant's Account 
upon the death of the Participant.

            1.4  "Board of Directors" means the Board of Directors of the 
Company, as constituted from time to time.

            1.5  "Committee" shall have the same meaning as assigned from time 
to time to the identical term under the Stock Option Plan.

            1.6  "Company" means Genentech, Inc., a Delaware corporation.

            1.7  "Consultant" means a Consultant (as defined from time to time 
under the Stock Option Plan) who, on the Effective Date, possesses one or more 
unvested, in-the-money Options which, on the Effective Date, will be cancelled 
under Article Six of the Stock Option Plan due to the occurrence of a 
Redemption or Delisting.

            1.8  "Delisting" means the failure of the Special Common Stock to 
be listed for trading on at least one of: (a) the New York Stock Exchange, (b) 
the Nasdaq National Market, or (c) any other national exchange.

            1.9  "Delisting Value" means the greater of (a) the arithmetic 
mean of the Closing Selling Prices (as defined in the Stock Option Plan) of 
the Special Common Stock on the twenty trading days immediately preceding the 
date on which Delisting occurs, or (b) $60 per share of Special Common Stock 
(adjusted for any reorganizations, consolidations, recapitalizations, stock 
dividends, split-ups, or other changes in the corporate structure of the 
Company which affect the Special Common Stock).

            1.10 "Disability" or "Disabled" means permanent and total 
disability as defined in section 22(e)(3) of the Internal Revenue Code of 
1986, as amended, including any valid regulation promulgated thereunder, and 
any comparable provision of any future legislation or regulation amending, 
supplementing or superseding such section or regulation.

            1.11 "Effective Date" means the date on which the Plan becomes 
effective.  The Plan shall become effective on the first to occur of a 
Redemption or Delisting.  The Plan shall not be effective prior to the 
occurrence of either such event.

            1.12 "Employee" means an employee of an Employer who, on the 
Effective Date, possesses one or more unvested, in-the-money Options which, on 
the Effective Date, will be cancelled under Article Six of the Stock Option 
Plan due to the occurrence of a Redemption or Delisting, irrespective of 
whether employment services are actually provided by the individual.

            1.13 "Employer" means the Company and each of its Affiliates that 
adopts the Plan as a participating Employer.  With respect to an individual 
Participant, Employer means the Company or the Affiliate that has adopted the 
Plan and that directly employs the Participant.

            1.14 "Employer Contributions" means the amounts credited to 
Participants' Accounts under the Plan pursuant to Section 3.

            1.15 "Nonemployee Director" means any individual who is a member 
of the Board of Directors of the Company (but who is an employee of neither 
the Company nor of any Affiliate) who, on the Effective Date, possesses one or 
more unvested, in-the-money Options which, on the Effective Date, will be 
cancelled under Article Six of the Stock Option Plan due to the occurrence of 
a Redemption or Delisting.

            1.16 "Option" means a stock option granted pursuant to the Stock 
Option Plan.

            1.17 "Parent" shall have the same meaning as assigned from time to 
time to the identical term under the Stock Option Plan.

            1.18 "Participant" means a Consultant, Employee or Nonemployee 
Director who (a) has become a Participant in the Plan pursuant to Section 2.1 
and (b) has not ceased to be a Participant pursuant to Section 2.2.

            1.19 "Plan" means the Genentech, Inc. Deferred Compensation Plan, 
as set forth in this instrument and as hereafter amended from time to time.

            1.20 "Redemption" means the redemption of the Special Common Stock 
as provided in Section (c)(ii) of Article Third of the Certificate of 
Incorporation of the Company.

            1.21 "Redemption Value" means the value specified for redemption 
of the Special Common Stock as set forth in Section (c)(ii)(A) of Article 
Third of the Certificate of Incorporation of the Company (and as adjusted 
pursuant to Section (c)(ii)(C) of Article Third of the Certificate of 
Incorporation).

            1.22 "Retirement" means the Participant's termination of 
employment with the Company and all of its Affiliates on account of his or her 
retirement at or after age 65.

            1.23 "Special Common Stock" shall have the same meaning as 
assigned from time to time to the identical term under the Stock Option Plan.

            1.24 "Stock Option Plan" means the Genentech, Inc. 1996 Stock 
Option/Stock Incentive Plan, as hereafter amended from time to time.

            1.25 "Subsidiary" shall have the same meaning as assigned from 
time to time to the identical term under the Stock Option Plan.


                                   SECTION 2
                                 PARTICIPATION

            2.1  Participation.  Each individual who is a Consultant, Employee 
or Nonemployee Director on the Effective Date automatically shall become a 
Participant in the Plan on such date.

            2.2  Termination of Participation.  An individual who has become a 
Participant shall remain a Participant until his or her entire vested Account 
balance is distributed.


                                   SECTION 3
                            EMPLOYER CONTRIBUTIONS

                  3.1  Employer Contributions.  On the Effective Date, each 
Participant shall have Employer Contributions credited to his or her 
Account(s) in an amount determined in the manner prescribed in this Section 
3.1.  If the Effective Date occurs due to a Delisting, such amount shall be 
determined in accordance with Section 3.1.1.  If the Effective Date occurs due 
to a Redemption, such amount shall be determined in accordance with Section 
3.1.2.  For each Participant, the calculation under Section 3.1.1 or Section 
3.1.2 (as the case may be) shall be performed for each of the Participant's 
unvested, in-the-money Options which are cancelled on the Effective Date due 
to the Delisting or Redemption.  Options which are not in-the-money (i.e., 
which have exercise prices greater than the Delisting Value or Redemption 
Value, whichever is applicable) shall not be considered for purposes of 
determining Employer Contributions.
                                                                          
                  3.1.1  Delisting.  With respect to any Option, the amount 
credited to a Participant's Account shall equal the product of:

            (a)   The amount by which the Delisting Value of a share exceeds 
the exercise price of the Option, times

            (b)  The number of shares covered by the Option.

                  3.1.2  Redemption.  With respect to any Option, the amount 
credited to a Participant's Account shall equal the product of:

            (a)  The amount by which the Redemption Value of a share exceeds 
the exercise price of the Option, times

            (b)  The number of shares covered by the Option.

            3.2  Crediting of Employer Contributions.  The Employer 
Contributions on any Option shall be credited to a separate Account created 
for each such Option.  All Employer Contributions shall be credited as of the 
Effective Date (but may or may not become vested, as provided in Section 6).  
The exact dollar amount to be credited shall be determined by the Committee 
under such formulas (consistent with the Plan) as the Committee shall adopt.

          3.3  Deemed Interest on Accounts.  Each Account shall be credited 
with deemed interest as of the end of each calendar quarter.  The annual rate 
for crediting deemed interest during any quarter (which rate shall be adjusted 
quarterly) shall be the rate paid by two-year U.S. Treasury notes (at 
issuance) which are last issued during such quarter.  Deemed interest under 
this Section 3.3 shall be calculated using a 360-day year and shall be 
compounded on a quarterly basis.

            3.4  Form and Timing of Payment.  On or prior to the Effective 
Date, each Participant shall elect the form and timing of payment for the 
vested portion (if any) of his or her Account(s).  A Participant may elect (a) 
payment as of each March 31, June 30, September 30 and December 31 (of all 
amounts which are then vested), (b) payment as of each June 30 and December 31 
(of all amounts which are then vested) or (c) payment of all vested amounts as 
soon as administratively practicable after the Participant's last scheduled 
vesting date.  A Participant later may change his or her election as to the 
form and timing of payment with respect to amounts which are scheduled to vest 
in any future calendar year.  However, any election under the preceding 
sentence will be effective only if (1) the election is received by the 
Committee (or its delegate) no later than last day of the calendar year prior 
to the year in which the amounts with respect to which the election is being 
made become vested, and (2) the Participant acknowledges in writing (in a form 
acceptable to the Committee) that any income tax consequences from the 
Participant's election will be solely the responsibility of the Participant.  
A Participant may not change his or her election with respect to already 
vested amounts.  Each election under this Section 3.4 shall be made in such 
manner as the Committee may specify.


                                   SECTION 4
                                  ACCOUNTING

            4.1  Participants' Accounts.  At the direction of the Committee, 
there shall be established and maintained on the books of the Company, a 
separate Account or Accounts for each Participant to which shall be credited 
Employer Contributions made on behalf of the Participant, and the deemed 
interest on such Employer Contributions.  A separate Account shall be 
established for the crediting of Employer Contributions (and deemed interest 
thereon) on each of the Participant's unvested, in-the-money Options which are 
cancelled on the Effective Date due to the Delisting or Redemption.

            4.2  Participants Remain Unsecured Creditors.  All amounts 
credited to a Participant's Account under the Plan shall continue for all 
purposes to be a part of the general assets of the Company.  Each 
Participant's interest in the Plan shall make him or her only a general, 
unsecured creditor of the Company.

            4.3  Accounting Methods.  The accounting methods or formulas to be 
used under the Plan for the purpose of maintaining the Participants' Accounts, 
including the calculation and crediting of any deemed interest shall be 
determined by the Committee in its sole discretion.  The accounting methods or 
formulas selected by the Committee may be revised from time to time.

            4.4  Reports.  Each Participant shall be furnished with periodic 
statements of his or her Account, reflecting the status of his or her interest 
in the Plan, at least annually.


                                  SECTION 5
                                DISTRIBUTIONS

            5.1  Normal Distribution Timing and Rules.  Subject to Sections 
5.2 and 5.3, distribution of the vested balance credited to a Participant's 
Account(s) shall be made as soon as administratively practicable after the 
date or dates elected by the Participant under Section 3.4.  Subject to the 
provisions of this Section 5, payment shall be made to the Participant, or in 
the event of the Participant's death, to the Participant's Beneficiary (or 
estate, as provided in Section 5.4).  A Participant (or Beneficiary) shall be 
paid all vested amounts credited to his or her Account(s) (if any) no later 
than the last scheduled vesting date for the applicable Option.

            5.2  Special Rule for Death or Disability.  If a Participant dies, 
the vested balance then credited to his or her Account (including any amounts 
vested pursuant to Section 6.2.2) shall be immediately distributed to the 
Participant's Beneficiary as soon as administratively practicable after the 
date of death.  If a Participant becomes Disabled, the vested balance credited 
to the Participant's Account (including any amounts vested pursuant to Section 
6.2.2) shall be distributed to the Participant at the time and in the form 
elected by the Participant pursuant to Section 3.4; provided, however, that 
the Committee, in its sole discretion, may elect to distribute the vested 
balance of the Participant's Account in a lump sum as of any date after the 
date of Disability.

            5.3  Special Rule for Termination of Employment.  If a Participant 
terminates his or her employment with the Company and all of its Affiliates 
for a reason other than death or Disability, the vested balance then credited 
to his or her Account shall be distributed to him or her in a lump sum as soon 
as administratively practicable after such termination.

          5.4  Beneficiary Designations.  Each Participant may, pursuant to 
such procedures as the Committee may specify, designate one or more 
Beneficiaries.

                  5.4.1  Spousal Consent.  If a Participant does not designate 
his or her spouse as sole primary Beneficiary, the beneficiary designation 
shall be ineffective unless such spouse consents to the designation.  Any 
spousal consent required under this Section 5.4 shall be ineffective unless it 
is set forth in writing and signed by the spouse.  Notwithstanding the 
preceding, if the Participant establishes to the satisfaction of the Company 
that written spousal consent may not be obtained because the spouse cannot be 
located, his or her designation shall be effective without a spousal consent. 
 Any spousal consent required under this Section 5.4 shall be valid only with 
respect to the spouse who signs the consent.

               5.4.2  Changes and Failed Designations.  A Participant may 
change or revoke Beneficiary designations by delivering a new designation (or 
revocation) in the manner described in Section 5.4.1.  Any designation or 
revocation shall be effective only if it is received by the Company.  However, 
when so received, the designation or revocation shall be effective as of the 
date the notice is executed (whether or not the Participant still is living), 
but without prejudice to the Company on account of any payment made before the 
change is recorded.  The last effective designation received by the Company 
shall supersede all prior designations.  If a Participant dies without having 
effectively designated a Beneficiary, or if no Beneficiary survives the 
Participant, the vested portion (if any) of the Participant's Account shall be 
payable (a) to his or her surviving spouse (if any), or (b) if the Participant 
is not survived by a spouse, to the Participant's estate.

            5.5  Financial Hardship.  In the event that a Participant incurs a 
"financial hardship", the Committee, in its sole discretion and 
notwithstanding any contrary provision of the Plan, may determine that all or 
part of the vested portion of the Participant's Account(s) shall be paid to 
him or her immediately; provided, however, that the amount paid to the 
Participant pursuant to this Section 5.5 shall be limited to the amount 
reasonably necessary to alleviate the Participant's hardship.  For purposes of 
this Section 5.5, a "financial hardship" shall mean a severe financial 
emergency which is caused by a sudden and unexpected accident, illness or 
other event beyond the control of the Participant which, without an acceler-
ated distribution from the Plan, would result in severe financial burden to 
the Participant or a member of his or her immediate family.  A financial 
hardship does not exist to the extent that the hardship may be relieved by 
(a) reimbursement or compensation by insurance, (b) liquidation of the 
Participant's other assets (to the extent such liquidation would not itself 
cause severe financial hardship), or (c) any loan available to the Participant 
(to the extent the payments on such loan would not themselves cause severe 
financial hardship).

            5.6  Payments to Incompetents.  If any individual to whom a 
benefit is payable under the Plan is a minor or legally incompetent, the 
Committee shall determine whether payment shall be made directly to the 
individual, any person acting as his or her custodian or legal guardian under 
the California Uniform Transfers to Minors Act, his or her legal 
representative or a near relative, or directly for his or her support, 
maintenance or education.

            5.7  Undistributable Accounts.  Each Participant (and in the event 
of the Participant's death, his or her Beneficiary) shall keep the Committee 
advised of his or her current address.  If the Committee is unable to locate 
the Participant or Beneficiary to whom a Participant's Account is payable 
under this Section 5, the Participant's Account shall be frozen and no further 
deemed interest under Section 3.3 shall be credited to the Account.  Accounts 
that, in accordance with the preceding sentence, have been undistributable for 
a period of 35 months shall be forfeited as of the end of the 35th month.  If 
a Participant whose Account was forfeited under this Section 5.7 (or his or 
her Beneficiary) files a claim for distribution of the Account after the date 
that it was forfeited, and if the Committee determines that such claim is 
valid, then the forfeited balance shall be paid in a lump sum cash payment as 
soon as administratively practicable thereafter (without any deemed interest 
for the period during which the account was frozen or forfeited).

            5.8  Payment in Cash or Its Equivalent.  All payments from the 
Plan shall be made in cash or its equivalent.

            5.9  Tax Withholding.  The Company shall withhold all applicable 
taxes from any payment, including but not limited to, any federal, FICA, 
state, and local income and employment taxes.

            5.10  Committee Discretion.  Within the specific time periods 
described in this Section 5, the Committee shall have sole discretion to 
determine the specific timing of the payment of any Account balance under the 
Plan.  


                                   SECTION 6
                       PARTICIPANT'S INTEREST IN ACCOUNT

            6.1  Vesting in Accounts.  A Participant's vested interest (if 
any) in his or her Account(s) shall be determined in accordance with Section 
6.2.  The vested portion of a Participant's Account(s) (if any) shall be 
distributed to the Participant in the manner and at the time set forth in 
Section 5, and any unvested portion shall be permanently forfeited as provided 
in Section 6.2.

            6.2  Vesting Rules.  With respect to each Account of a 
Participant, his or her interest in the Account shall be vested in accordance 
with the same schedule, and on the same terms and conditions, as the Option 
(or applicable portion thereof) with respect to which the Employer 
Contributions in the Account were calculated.  For example, suppose that 
Employer Contributions of $4,000 are credited to a Participant's Account on 
January 10, 1998, based on an Option covering 200 shares of Special Common 
Stock.  If the Option had been scheduled to vest as to 100 shares on June 30, 
1998, and as to the remaining 100 shares on June 30, 1999, the Participant 
would be scheduled to vest in $2,000 of Employer Contributions (and deemed 
interest thereon) on June 30, 1998, and as to an additional $2,000 of Employer 
Contributions (and deemed interest thereon) on June 30, 1999.  On any 
scheduled vesting date, vesting actually will occur only if the terms and 
conditions set forth in the applicable Option agreement are satisfied (for 
example, with respect to continuous employment with the Company and 
Affiliates).  Consistent with the Plan, the specific vesting schedule for any 
Account shall be determined by the Committee in its discretion.

                  6.2.1  Termination.  Upon termination of the Participant's 
employment with all Employers and Affiliates for any reason at any time, the 
vested portion of his or her Account(s) shall be distributable to him or her 
in the manner and at the times set forth in Section 5, and the unvested 
portion of such Account shall be permanently forfeited.

                  6.2.2  Full Vesting.  Notwithstanding any contrary provision 
of Section 6.2.1, a Participant's interest in his or her entire Account may 
become 100% vested and nonforfeitable in accordance with the rules of this 
Section 6.2.2.  A Participant's interest in his or her entire Account shall 
become 100% vested and nonforfeitable upon the date of his or her death or 
Retirement.  If a Participant becomes Disabled, the Committee, in its sole 
discretion, may provide that all or part of the Participant's Account shall 
become vested upon the date of his or her Disability.

                 6.3  Transfers of Employment.  The transfer of a Participant 
from employment with an Employer to employment with another Affiliate shall 
not constitute a termination of employment under the Plan.  Upon termination 
of his or her employment with such other Affiliate (other than for transfer to 
employment with another Affiliate), the Participant's employment shall be 
deemed then to have terminated.


                                   SECTION 7
                          ADMINISTRATION OF THE PLAN

            7.1  Committee.  The Plan shall be administered by the Committee. 
The Committee shall have the authority to control and manage the operation and 
administration of the Plan.

            7.2  Actions by Committee.  Each decision of a majority of the 
members of the Committee then in office shall constitute the final and binding 
act of the Committee.  The Committee may act with or without a meeting being 
called or held and shall keep minutes of all meetings held and a record of all 
actions taken by written consent.

            7.3  Powers of Committee.  The Committee shall have all powers and 
discretion necessary or appropriate to supervise the administration of the 
Plan and to control its operation in accordance with its terms, including, but 
not by way of limitation, the following powers:

            (a)   To interpret and determine the meaning and validity of the 
provisions of the Plan and to determine any question arising under, or 
in connection with, the administration, operation or validity of the 
Plan or any amendment thereto;

            (b)   To determine any and all considerations affecting the 
eligibility of any employee to become a Participant or remain a 
Participant in the Plan;

            (c)   To cause one or more separate Accounts to be maintained for 
each Participant;

            (d)   To cause Employer Contributions and deemed interest to be 
credited to Participants' Accounts;

            (e)   To establish and revise an accounting method or formula for 
the Plan, as provided in Section 4.3;

            (f)   To determine the status and rights of Participants and 
their spouses, Beneficiaries or estates;

            (g)   To employ such counsel, agents and advisers, and to obtain 
such legal, clerical and other services, as it may deem necessary or 
appropriate in carrying out the provisions of the Plan;

            (h)   To establish, from time to time, rules for the performance 
of its powers and duties and for the administration of the Plan;

            (i)   To arrange for annual distribution to each Participant of a 
statement of benefits accrued under the Plan;

            (j)   To publish a claims and appeal procedure pursuant to which 
individuals or estates may claim Plan benefits and appeal denials of 
such claims;

            (k)   To delegate to any one or more of its members or to any 
other person, severally or jointly, the authority to perform for and on 
behalf of the Committee one or more of the functions of the Committee 
under the Plan; and

            (l)   To decide all issues and questions regarding Account 
balances, and the time, form, manner, and amount of distributions to 
Participants.

            7.4  Decisions of Committee.  All actions, interpretations, and 
decisions of the Committee shall be conclusive and binding on all persons, and 
shall be given the maximum deference permitted by law.

            7.5  Administrative Expenses.  All expenses incurred in the 
administration of the Plan by the Committee, or otherwise, including legal 
fees and expenses, shall be paid and borne by the Employers.

            7.6  Eligibility to Participate.  No member of the Committee who 
also is a Participant shall be excluded from participating in the Plan, but as 
a member of the Committee, he or she shall not be entitled to act or pass upon 
any matters pertaining specifically to his or her own Account.

            7.7  Indemnification.  Each of the Employers shall, and hereby 
does, indemnify and hold harmless the members of the Committee, from and 
against any and all losses, claims, damages or liabilities (including 
attorneys' fees and amounts paid, with the approval of the Board of Directors, 
in settlement of any claim) arising out of or resulting from the 
implementation of a duty, act or decision with respect to the Plan, so long as 
such duty, act or decision does not involve gross negligence or willful 
misconduct on the part of any such individual.


                                  SECTION 8
                                   FUNDING

            8.1  Unfunded Plan.  All amounts credited to a Participant's 
Account under the Plan shall continue for all purposes to be a part of the 
general assets of the Company.  The interest of the Participant in his or her 
Account, including his or her right to distribution thereof, shall be an 
unsecured claim against the general assets of the Company.  Nothing contained 
in the Plan shall give any Participant or Beneficiary any interest in or claim 
against any specific assets of the Company.


                                  SECTION 9
                     MODIFICATION OR TERMINATION OF PLAN

            9.1  Employers' Obligation is Limited.  The Employers intend to 
continue the Plan indefinitely, and to maintain each Participant's Account 
until it is scheduled to be paid to him or her in accordance with the 
provisions of the Plan.  However, the Plan is voluntary on the part of the 
Employers, and the Employers do not guarantee to continue the Plan.  The 
Company at any time may amend the Plan, with or without cause.

            9.2  Right to Amend or Terminate.  The Board of Directors reserves 
the right to alter, amend or terminate the Plan, or any part thereof, at any 
time and for any reason provided that (a) no amendment or termination of the 
Plan shall, without the consent of the Participant, reduce the vested balance 
then credited to the Participant's Account, and (b) the Plan shall not be 
terminated until all vested amounts (and amounts which possibly still may 
vest) have been distributed to the Participants (or Beneficiaries).  


                                  SECTION 10
                              GENERAL PROVISIONS

            10.1  Inalienability.  In no event may either a Participant, a 
former Participant or his or her Beneficiary, spouse or estate sell, transfer, 
anticipate, assign, hypothecate, or otherwise dispose of any right or interest 
under the Plan; and such rights and interests shall not at any time be subject 
to the claims of creditors nor be liable to attachment, execution or other 
legal process.  Accordingly, for example, a Participant's interest in the Plan 
is not transferable pursuant to a domestic relations order.

            10.2  Participation by Affiliates.  One or more Affiliates of the 
Company may become participating Employers by adopting the Plan.  By adopting 
the Plan, an Affiliate is deemed to agree to all of its terms, including (but 
not limited to) the provisions granting exclusive authority to the Board of 
Directors to amend the Plan and the provisions granting exclusive authority to 
the Committee to administer and interpret the Plan.  Any Affiliate may 
terminate its participation in the Plan at any time by resolution of its board 
of directors.  The liabilities incurred under the Plan to the Participants 
shall be solely the liabilities of the Company, and no other Employer shall be 
liable for benefits accrued under the Plan.  An Affiliate's participation in 
the Plan shall be deemed terminated if it ceases to be an Affiliate.

            10.3  Rights and Duties.  Neither the Employers nor the Committee 
shall be subject to any liability or duty under the Plan except as expressly 
provided in the Plan, or for any action taken, omitted or suffered in good 
faith.

            10.4  Apportionment of Costs and Duties.  All acts required of the 
Employers under the Plan may be performed by the Company for itself and its 
Affiliates, and the costs of the Plan may be equitably apportioned by the 
Committee among the Company and the other Employers.

            10.5  No Effect on Employment.  Neither the establishment or 
maintenance of the Plan, the making of any Employer Contributions nor any 
action of any Employer or the Committee, shall be held or construed to confer 
upon any individual any right to be continued as an employee, or upon 
dismissal, any right or interest in any specific assets of the Employers other 
than as provided in the Plan.  Each Employer expressly reserves the right to 
discharge any employee at any time, with or without cause.

            10.6  Employer Contributions Not Counted Under Other Employee 
Benefit Plans.  Employer Contributions under the Plan will not be considered 
for purposes of contributions or benefits under any other employee benefit 
plan sponsored by the Employers.

            10.7  Compliance with Rule 16b-3.  Payments under the Plan are 
intended to be exempt from liability under section 16 of the Securities 
Exchange Act of 1934, as amended ("section 16").  To the extent deemed 
necessary or advisable by the Committee, any payment to an individual who is 
subject to section 16(a) with respect to the Special Common Stock may be 
delayed in order to ensure that such payment will not result in any liability 
under section 16(b) to such individual.

            10.8  Applicable Law.  The provisions of the Plan shall be 
construed, administered and enforced in accordance with the laws of the State 
of California (other than its conflict of laws provisions).

            10.9  Severability.  If any provision of the Plan is held invalid 
or unenforceable, its invalidity or unenforceability shall not affect any 
other provisions of the Plan, and in lieu of each provision which is held 
invalid or unenforceable, there shall be added as part of the Plan a provision 
that shall be as similar in terms to such invalid or unenforceable provision 
as may be possible and be valid, legal, and enforceable.

            10.10  Captions.  The captions contained in and the table of 
contents prefixed to the Plan are inserted only as a matter of convenience and 
for reference and in no way define, limit, enlarge or describe the scope or 
intent of the Plan nor in any way shall affect the construction of any 
provision of the Plan.

                                  EXECUTION

            IN WITNESS WHEREOF, the Company, by its duly authorized officers, 
has executed the Plan on the date indicated below.

                                    GENENTECH, INC.



Dated:                              By:                            
                                    Title:






                                GENENTECH, INC.
                          DEFERRED COMPENSATION PLAN


                         TABLE OF CONTENTS

                                                             Page

SECTION 1  DEFINITIONS

     1.1  "Account" or "Account(s)"                             1
     1.2  "Affiliate"                                           1
     1.3  "Beneficiary"                                         1
     1.4  "Board of Directors"                                  1
     1.5  "Committee"                                           1
     1.6  "Company"                                             1
     1.7  "Consultant"                                          1
     1.8  "Delisting"                                           1
     1.9  "Delisting Value"                                     2
     1.10 "Disability"                                          2
     1.11 "Effective Date"                                      2
     1.12 "Employee"                                            2
     1.13 "Employer"                                            2
     1.14 "Employer Contributions"                              2
     1.15 "Nonemployee Director"                                2
     1.16 "Option"                                              2
     1.17 "Parent"                                              2
     1.18 "Participant"                                         3
     1.19 "Plan"                                                3
     1.20 "Redemption"                                          3
     1.21 "Redemption Value"                                    3
     1.22 "Retirement"                                          3
     1.23 "Special Common Stock"                                3
     1.24 "Stock Option Plan"                                   3
     1.25 "Subsidiary"                                          3

SECTION 2  PARTICIPATION

     2.1  Participation                                         3
     2.2  Termination of Participation                          3

SECTION 3  EMPLOYER CONTRIBUTIONS

     3.1  Employer Contributions                                4
            3.1.1  Delisting                                    4
            3.1.2  Redemption                                   4
     3.2  Crediting of Employer Contributions                   4
     3.3  Deemed Interest on Accounts                           4
     3.4  Form and Timing of Payment                            5

SECTION 4  ACCOUNTING

     4.1  Participants' Accounts                                5
     4.2  Participants Remain Unsecured Creditors               5
     4.3  Accounting Methods                                    5
     4.4  Reports                                               6

SECTION 5  DISTRIBUTIONS

     5.1  Normal Distribution Timing and Rules                  6
     5.2  Special Rule for Death or Disability                  6
     5.3  Special Rule for Termination of Employment            6
     5.4  Beneficiary Designations                              6
            5.4.1  Spousal Consent                              6
            5.4.2  Changes and Failed Designations              7
     5.5  Financial Hardship                                    7
     5.6  Payments to Incompetents                              7
     5.7  Undistributable Accounts                              8
     5.8  Payment in Cash or Its Equivalent                     8
     5.9  Tax Withholding                                       8
     5.10 Committee Discretion                                  8

SECTION 6  PARTICIPANT'S INTEREST IN ACCOUNT

     6.1  Vesting in Accounts                                   8
     6.2  Vesting Rules                                         8
            6.2.1  Termination                                  9
            6.2.2  Full Vesting                                 9
     6.3  Transfers of Employment                               9

SECTION 7  ADMINISTRATION OF THE PLAN

     7.1  Committee                                             9
     7.2  Actions by Committee                                 10
     7.3  Powers of Committee                                  10
     7.4  Decisions of Committee                               11
     7.5  Administrative Expenses                              11
     7.6  Eligibility to Participate                           11
     7.7  Indemnification                                      11

SECTION 8  FUNDING

     8.1  Unfunded Plan                                        11

SECTION 9  MODIFICATION OR TERMINATION OF PLAN

     9.1  Employers' Obligation is Limited                     12
     9.2  Right to Amend or Terminate                          12

SECTION 10  GENERAL PROVISIONS

     10.1  Inalienability                                      12
     10.2  Participation by Affiliates                         12
     10.3  Rights and Duties                                   13
     10.4  Apportionment of Costs and Duties                   13
     10.5  No Effect on Employment                             13
     10.6  Employer Contributions Not Counted Under Other Employee Benefit 
Plans                             13
     10.7  Compliance with Rule 16b-3                          13
     10.8  Applicable Law                                      13
     10.9  Severability                                        13
     10.10 Captions                                            13

 



 

 






	








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