GENENTECH INC
S-8, 1997-07-17
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
     As filed with the Securities and Exchange Commission on July 17, 1997.
                                                          Registration No. 333-
- -------------------------------------------------------------------------------



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                      ------------------------------------


                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                      ------------------------------------



                                 GENENTECH, INC.
             (Exact name of registrant as specified in its charter)

                Delaware                                     94-2347624
      (State or other jurisdiction                        (I.R.S. employer
    of incorporation or organization)                  identification number)

                                   1 DNA Way
                      SOUTH SAN FRANCISCO, CALIFORNIA 94080
                                 (415) 225-1000
               (Address, including zip code, and telephone number,
                 including area code, of registrant's principal
                               executive offices)

                      ------------------------------------


                              STEPHEN G. JUELSGAARD
                  VICE PRESIDENT, GENERAL COUNSEL AND SECRETARY
                                 GENENTECH, INC.
                                   1 DNA Way
                      SOUTH SAN FRANCISCO, CALIFORNIA 94080
                                 (415) 225-1000
       (Name, address, including zip code, and telephone number, including
                        area code, of agent for service)
<TABLE>
<CAPTION>


                                         CALCULATION OF REGISTRATION FEE
================================================================================================================
                                                             Proposed
                                                             Maximum            Maximum
       Title of Each Class of           Amount to be      Offering Price       Aggregate          Amount of
    Securities to be Registered          Registered        per Share(1)    Offering Price(1)   Registration Fee
- ----------------------------------------------------------------------------------------------------------------
<S>                                    <C>                   <C>             <C>                   <C>               
Callable Putable Common Stock, $.02
par value                              700,000 shares        $58.34          $40,838,000           $14,083
================================================================================================================
</TABLE>
(1)  Estimated solely for the purpose of calculating the registration fee in
     accordance with Rules 457(h) and 457(c) under the Securities Act of 1933
     and based upon the average of the high and low prices reported on the New
     York Stock Exchange on July 11, 1997.


- -------------------------------------------------------------------------------
                                             Page 1 of 8 Pages
                                    Exhibit Index Located at Page II-5
<PAGE>   2
                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

         In accordance with General Instruction E to Form S-8, the contents of
the Registrant's Registration Statements on Form S-8, Commission File No.
33-39631, No. 33-60816, No. 33-60277 and No. 33-59949, including exhibits
thereto, are hereby incorporated by reference into this Registration Statement,
except as the same may be modified by the information set forth herein.

Item 8.  EXHIBITS
<TABLE>
<CAPTION>

      Exhibit
      Number      Description
      ------      -----------
<S>               <C>
         4.1      Amended Certificate of Incorporation of Registrant (1)

         5.1      Opinion of Counsel

        15.1      Letter from Ernst & Young LLP Regarding Unaudited Interim Financial Information

        23.1      Consent of Counsel (included in Exhibit 5.1)

        23.2      Consent of Ernst & Young LLP, Independent Auditors

        24.1      Power of Attorney (see page II-3)

        99.1      1991 Employee Stock Plan, as amended effective April 10, 1997 (2)
</TABLE>

     (1) Filed as an exhibit to Form S-4 dated October 25, 1995 (Registration
         Statement No. 33-5994) and incorporated herein by reference.

     (2) Filed as an exhibit to the Registrant's Quarterly Report on Form 10-Q
         for the period ended March 31, 1997.

                                      II-2
<PAGE>   3
                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant, Genentech, Inc., certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly caused
this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of South San Francisco, State of
California, on July 14, 1997.

                              GENENTECH, INC.


                              By:      /s/ Stephen G. Juelsgaard
                                      -----------------------------------------
                                      Stephen G. Juelsgaard
                                      Vice President, General Counsel
                                      and Secretary


                                POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Louis J. Lavigne, Jr. and Stephen G.
Juelsgaard, and each of them, as his true and lawful attorneys-in-fact and
agents, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all amendments
to this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated, as of July 14, 1997.
<TABLE>
<CAPTION>
           SIGNATURE                                            TITLE
           ---------                                             -----
<S>                                                <C>
Principal Executive Officer:


/s/ Arthur D. Levinson                              President, Chief Executive 
- ------------------------------------                   Officer and Director
Arthur D. Levinson                                             

Principal Financial Officer:


/s/ Louis J. Lavigne, Jr.                           Executive Vice President and
- ------------------------------------                  Chief Financial Officer
Louis J. Lavigne, Jr.                                          

Principal Accounting Officer:


/s/ Bradford S. Goodwin                             Vice President, Finance 
- -----------------------------------                     and Controller
Bradford S. Goodwin
</TABLE>

                                                  II

<PAGE>   4

Directors:


/s/ Herbert W. Boyer                                                   Director
- -----------------------------------
Herbert W. Boyer


/s/ Jurgen Drews                                                       Director
- -----------------------------------
Jurgen Drews


/s/ Franz B. Humer                                                     Director
- -----------------------------------
Franz B. Humer


/s/ Linda Fayne Levinson                                               Director
- -----------------------------------
Linda Fayne Levinson


/s/ J. Richard Munro                                                   Director
- -----------------------------------
J. Richard Munro


/s/ Donald L. Murfin                                                   Director
- -----------------------------------
Donald L. Murfin


/s/ John T. Potts, Jr.                                                 Director
- -----------------------------------
John T. Potts, Jr.


/s/ C. Thomas Smith, Jr.                                               Director
- -----------------------------------
C. Thomas Smith, Jr.


/s/ David S. Tappan, Jr.                                               Director
- -----------------------------------
David S. Tappan, Jr.

                                                  II-4

<PAGE>   5
<TABLE>
<CAPTION>

                                INDEX TO EXHIBITS

     Number       Description
     -----        -----------
<S>               <C>
        4.1       Amended Certificate of Incorporation of Registrant (1)

        5.1       Opinion of Counsel

       15.1       Letter from Ernst & Young LLP Regarding Unaudited Interim Financial Information

       23.1       Consent of Counsel (included in Exhibit 5.1)

       23.2       Consent of Ernst & Young LLP, Independent Auditors

       24.1       Power of Attorney (see page II-3)

       99.1       1991 Employee Stock Plan, as amended effective April 10, 1997 (2)
</TABLE>

     (1) Filed as an exhibit to Form S-4 dated October 25, 1995 (Registration
         Statement No. 33-5994) and incorporated herein by reference.

     (2) Filed as an exhibit to the Registrant's Quarterly Report on Form 10-Q
         for the period ended March 31, 1997. 

                                      II-5


<PAGE>   1
                                                                    EXHIBIT 5.1
[GENENTECH, INC. LETTERHEAD]

                                                     July 16, 1997



Genentech, Inc.
460 Point San Bruno Boulevard
South San Francisco, CA  94080

Ladies and Gentlemen:

     I am General Counsel of Genentech, Inc. (the "Company"), and am rendering
this opinion in connection with the filing by the Company of a Registration
Statement on Form S-8 (the "Registration Statement") with the Securities and
Exchange Commission with respect to the offering and sale of up to 700,000
shares of the Company's Callable Putable Common Stock (the "Special Common
Stock") pursuant to the Company's 1991 Employee Stock Plan, as amended (the
"Plan").

     In connection with rendering this opinion, I have examined and relied upon
the Registration Statement and related Prospectus, the Plan described in the
Registration Statement and the documents to be executed pursuant thereto, the
Company's Certificate of Incorporation and Bylaws, as amended, and such records,
documents, certificates, memoranda, and other instruments as in my judgment are
necessary or appropriate to enable me to render the opinion expressed below.

     On the basis of the foregoing, and in reliance thereon, I am of the opinion
that the Special Common Stock when sold and issued in accordance with the Plan
and the documents to be executed pursuant thereto, the Registration Statement
and the related Prospectus, will be validly issued, fully paid and
nonassessable.

     I consent to the filing of this opinion as an exhibit to the Registration
Statement.

                                   Very truly yours,



                                   /s/  Stephen G. Juelsgaard
                                   -----------------------------
                                   Stephen G. Juelsgaard
                                   Vice President, General Counsel and Secretary


                                      II-6


<PAGE>   1
                                                                  EXHIBIT 15.1


July 16, 1997


The Board of Directors and Stockholders
Genentech, Inc.

We are aware of the incorporation by reference in the Registration Statement
(Form S-8) pertaining to the 1991 Employee Stock Plan of Genentech, Inc. of our
report dated April 8, 1997 relating to the unaudited condensed consolidated
interim financial statements of Genentech, Inc. which are included in its Form
10-Q for the quarter ended March 31, 1997.

Pursuant to Rule 436(c) of the Securities Act of 1933 our report is not a part
of the registration statement prepared or certified by accountants within the
meaning of Section 7 or 11 of the Securities Act of 1933.

                                Very truly yours,


                                /s/  Ernst & Young LLP
                                --------------------------------
                                Ernst & Young LLP


                                      II-7

<PAGE>   1
                                                                   EXHIBIT 23.2



               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement on
Form S-8 pertaining to the 1991 Employee Stock Plan of Genentech, Inc. of our
report dated January 17, 1997, with respect to the consolidated financial
statements of Genentech, Inc. incorporated by reference in its Annual Report
(Form 10-K) for the year ended December 31, 1996 and the related financial
statement schedule included therein, filed with the Securities and Exchange     
Commission.



                                                /s/  Ernst & Young LLP
                                                
San Jose, California                            
July 16, 1997

                                      II-8


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