GENENTECH INC
S-3/A, EX-15.1, 2000-08-04
PHARMACEUTICAL PREPARATIONS
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                                                                   Exhibit 15.1



               Letter re: Unaudited Interim Financial Information



August 2, 2000


The Board of Directors and Stockholders
Genentech, Inc.

     We are aware of the incorporation by reference in the registration
statement (Form S-3, Amendment No. 1) of Genentech, Inc., for the registration
of 6,517,309 shares of its common stock, of our report dated April 10, 2000
relating to the unaudited condensed consolidated interim financial statements
of Genentech, Inc. that are included in its Form 10-Q for the quarter ended
March 31, 2000.

     Pursuant to Rule 436(c) of the Securities Act of 1933 our report dated
April 10, 2000 is not a part of the registration statement prepared or
certified by accountants within the meaning of Section 7 or 11 of the
Securities Act of 1933.


                                                   Very Truly Yours,


                                                   /s/ Ernst & Young LLP


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