GENENTECH INC
SC 13G, 2000-04-10
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                            -----------------------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)



                                 Genentech, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   368710406
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

- --------------------------------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
     |_| Rule 13d-1(b)
     |_| Rule 13d-1(c)
     |X| Rule 13d-1(d)

- --------
     * The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

<PAGE>


CUSIP No.  368710406               13G                   Page ___ of ___ Pages

- --------------------------------------------------------------------------------
   1.    NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         Roche Holdings, Inc.                       51-0304944
- --------------------------------------------------------------------------------
   2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)|_|


- --------------------------------------------------------------------------------
   3.    SEC USE ONLY


- --------------------------------------------------------------------------------
   4.    CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware
- --------------------------------------------------------------------------------

                              5.     SOLE VOTING POWER            153,297,176
       NUMBER OF
        SHARES                --------------------------------------------------
     BENEFICIALLY
       OWNED BY               6.     SHARED VOTING POWER
         EACH
      REPORTING               --------------------------------------------------
     PERSON WITH
                              7.     SOLE DISPOSIT                153,297,176

                              --------------------------------------------------
                              8.     SHARED DISPOSITIVE POWER

- --------------------------------------------------------------------------------
   9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         153,297,176
- --------------------------------------------------------------------------------

  10.    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES               |_|
         CERTAIN SHARES*

- --------------------------------------------------------------------------------
  11.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         58.9%
- --------------------------------------------------------------------------------
  12.    TYPE OF REPORTING PERSON*

         CO
- -------- -----------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>



Item 1(a). Name of Issuer:

     Genentech, Inc.

Item 1(b). Address of Issuer's Principal Executive Offices:

     One DNA Way, South San Francisco, CA 94080

Item 2(a). Name of Person Filing:

     Roche Holdings, Inc., an indirect wholly-owned subsidiary of Roche Holding
Ltd

Item 2(b). Address of Principal Business Office or, if None, Residence:

     One Commerce Center, Suite 1050, Wilmington, DE 19801

Item 2(c). Citizenship:

     Not applicable

Item 2(d). Title of Class of Securities:

     Common Stock

Item 2(e). CUSIP Number:

     368710406

Item 3.    If this Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b)
           or (c), Check Whether the Person Filing is a:

     (a)   |_| Broker or dealer registered under Section 15 of the Exchange Act;

     (b)   |_| Bank as defined in Section 3(a)(6) of the Exchange Act;

     (c)   |_| Insurance company as defined in Section 3(a)(19) of the Exchange
               Act;

     (d)   |_| Investment company registered under Section 8 of the Investment
               Company Act;

     (e)   |_| An investment adviser in accordance with Rule
               13d-1(b)(1)(ii)(E);

     (f)   |_| An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F);

     (g)   |_| A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G);

     (h)   |_| A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act;

     (i)   |_| A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act;
     (j)   |_| Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     If this statement is filed pursuant to Rule 13d-1(c), check this box. |_|

                                       2

<PAGE>



Item 4.   Ownership.  (As of March 29, 2000)

     Provide the following information regarding the aggregate number and
percentage of the class of securities of issuer identified in Item 1.

     (a)   Amount beneficially owned: 153,297,176

     (b)   Percent of class: 58.9%

     (c)   Number of shares as to which such person has:

           (i)  Sole power to vote or to direct the vote: 153,297,176

          (ii)  Shared power to vote or to direct the vote:

         (iii)  Sole power to dispose or to direct the disposition of:
                153,297,176

          (iv)  Shared power to dispose or to direct the disposition of:

Item 5.   Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following. |_|

Item 6.    Ownership of More than Five Percent on Behalf of Another Person.

     Not applicable

Item 7.    Identification and Classification of the Subsidiary Which Acquired
           the Security Being Reported on by the Parent Holding Company.

     Not applicable

Item 8.    Identification and Classification of Members of the Group.

     Not applicable

Item 9.    Notice of Dissolution of Group.

     Not applicable

Item 10.   Certifications.

     Not applicable (Rule 13d-1(d))

                                       3

<PAGE>


     SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                                         April 10, 2000
                                                  ----------------------------
                                                             (Date)

                                                       /s/ Henri Meier
                                                  ----------------------------
                                                           (Signature)

                                                        Henri Meier, CFO
                                                  ----------------------------
                                                          (Name/Title)


         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative (other than an
executive officer or general partner of the filing person), evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

         Attention.  Intentional misstatements or omissions of fact constitute
federal criminal violations (see 18 U.S.C. 1001).

                                       4



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