GENENTECH INC
S-3/A, EX-15.1, 2000-10-23
PHARMACEUTICAL PREPARATIONS
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                                                                    Exhibit 15.1

               Letter re: Unaudited Interim Financial Information

October 17, 2000


The Board of Directors and Stockholders
Genentech, Inc.

     We are aware of the incorporation by reference in the registration
statement (Form S-3, Amendment No. 2) of Genentech, Inc., for the registration
of 6,517,309 shares of its common stock, of our reports dated April 10, 2000 and
July 12, 2000 relating to the unaudited condensed consolidated interim financial
statements of Genentech, Inc. that are included in its Forms 10-Q for the
quarters ended March 31, 2000 and June 30, 2000.

     Pursuant to Rule 436(c) of the Securities Act of 1933 our report dated
April 10, 2000 is not a part of the registration statement prepared or certified
by accountants within the meaning of Section 7 or 11 of the Securities Act of
1933.

                                                    Very Truly Yours,


                                                    /s/ Ernst & Young LLP




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