GENENTECH INC
SC 13G, 2000-06-07
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                               -------------------


                                  SCHEDULE 13G

                            (AMENDMENT NO.__________)*

                                  VaxGen, Inc.
-------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
-------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   922390 20 8
-------------------------------------------------------------------------------
                                 (CUSIP Number)

                                February 15, 2000
-------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

        [ ] Rule 13d-1(b)
        [ ] Rule 13d-1(c)
        [X] Rule 13d-1(d)

--------

      * The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

      The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

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-------------------------------------------------------------------------------

CUSIP No. 922390-20-8               13G             Page ____ OF _______ PAGES

-------------------------------------------------------------------------------
  1.    NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
        Genentech, Inc.
        94-2347624
-------------------------------------------------------------------------------
  2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*               (a)[ ]
        Not Applicable                                                  (b)[ ]
-------------------------------------------------------------------------------
  3.    SEC USE ONLY
-------------------------------------------------------------------------------
  4.    CITIZENSHIP OR PLACE OF ORGANIZATION

        Delaware
-------------------------------------------------------------------------------
                5.  SOLE VOTING POWER   1,522,354 shares of Common Stock
    NUMBER OF   ---------------------------------------------------------------
      SHARES
   BENEFICIALLY 6.  SHARED VOTING POWER                                0
     OWNED BY   ---------------------------------------------------------------
       EACH
    REPORTING   7.  SOLE DISPOSITIVE POWER    1,522,354 shares of Common Stock
   PERSON WITH  ---------------------------------------------------------------
                8.  SHARED DISPOSITIVE POWER                           0

-------------------------------------------------------------------------------
  9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        1,522,354 shares of Common Stock
-------------------------------------------------------------------------------
  10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                               [ ]

-------------------------------------------------------------------------------
  11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        11.2% of Common Stock

-------------------------------------------------------------------------------
  12.   TYPE OF REPORTING PERSON*

        CO
-------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>   3

ITEM 1(a).  NAME OF ISSUER:

     VaxGen, Inc.

ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

     1000 Marina Boulevard, Suite 200, Brisbane, CA 94005

ITEM 2(a).  NAME OF PERSON FILING:

     Genentech, Inc.

ITEM 2(b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:

     1 DNA Way, South San Francisco, CA 94082

ITEM 2(c).  CITIZENSHIP:

     Not Applicable

ITEM 2(d).  TITLE OF CLASS OF SECURITIES:

     Common Stock

ITEM 2(e).  CUSIP NUMBER:

     922390 20 8

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b) OR
        (c), CHECK WHETHER THE PERSON FILING IS A:

  (a) [ ] Broker or dealer registered under Section 15 of the Exchange Act;

  (b) [ ] Bank as defined in Section 3(a)(6) of the Exchange Act;

  (c) [ ] Insurance company as defined in Section 3(a)(19) of the Exchange Act;

  (d) [ ] Investment company registered under Section 8 of the Investment
          Company Act;

  (e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

  (f) [ ] An employee benefit plan or endowment fund in accordance with Rule
          13d-1(b)(1)(ii)(F);

  (g) [ ] A parent holding company or control person in accordance with Rule
          13d-1(b)(1)(ii)(G);

  (h) [ ] A savings association as defined in Section 3(b) of the Federal
          Deposit Insurance Act;

  (i) [ ] A church plan that is excluded from the definition of an investment
          company under Section 3(c)(14) of the Investment Company Act;

  (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

   If this statement is filed pursuant to Rule 13d-1(c), check this box. [ ]



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<PAGE>   4

ITEM 4. OWNERSHIP.

     Provide the following information regarding the aggregate number and
percentage of the class of securities of issuer identified in Item 1.

     (a) Amount beneficially owned:  1,522,354 shares of Common Stock

     (b) Percent of class: 11.2%

     (c) Number of shares as to which such person has:

        (i)  Sole power to vote or to direct the vote: 1,522,354 shares of
             Common Stock

       (ii)  Shared power to vote or to direct the vote: 0

      (iii)  Sole power to dispose or to direct the disposition of: 1,522,354
             shares of Common Stock

       (iv)  Shared power to dispose or to direct the disposition of:  0

ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following. [ ]

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

     Not Applicable.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
         SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

     Not Applicable

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

     Not Applicable

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP.

     Not Applicable

ITEM 10. CERTIFICATIONS.

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.



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                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                             June 7, 2000
                        ------------------------------------------------------
                                                (Date)
                                     /s/ STEPHEN G. JUELSGAARD
                        ------------------------------------------------------
                                             (Signature)

                        Stephen G. Juelsgaard, Senior Vice President, General
                                          Counsel and Secretary
                        ------------------------------------------------------
                                             (Name/Title)


        The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative (other than an
executive officer or general partner of the filing person), evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

        Attention.  Intentional misstatements or omissions of fact constitute
federal criminal violations (see 18 U.S.C. 1001).


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