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SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities
Exchange Act of 1934 (Amendment No. )
Filed by the Registrant [_]
Filed by a Party other than the Registrant [_]
Check the appropriate box:
[_] Preliminary Proxy Statement [_] Confidential, for Use of the
Commission Only (as permitted by
Rule 14a-6(e)(2))
[X] Definitive Proxy Statement
[_] Definitive Additional Materials
[_] Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12
Genentech, Inc.
- --------------------------------------------------------------------------------
(Name of Registrant as Specified In Its Charter)
Genentech, Inc.
- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check the appropriate box):
[X] No fee required.
[_] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
(1) Title of each class of securities to which transaction applies:
(2) Aggregate number of securities to which transaction applies:
(3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
the filing fee is calculated and state how it was determined):
(4) Proposed maximum aggregate value of transaction:
(5) Total fee paid:
[_] Fee paid previously with preliminary materials.
[_] Check box if any part of the fee is offset as provided by Exchange
Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee
was paid previously. Identify the previous filing by registration statement
number, or the Form or Schedule and the date of its filing.
(1) Amount Previously Paid:
(2) Form, Schedule or Registration Statement No.:
(3) Filing Party:
(4) Date Filed:
Notes:
<PAGE>
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON
MAY 15, 2000
[GENENTECH, INC. LOGO]
To the Stockholders of Genentech, Inc.:
Notice is hereby given that the 2000 Annual Meeting (the "Annual Meeting")
of the stockholders of Genentech, Inc. (the "Company") will be held at the
Westin Hotel, 1 Old Bayshore Highway, Millbrae, California, on Monday, May 15,
2000, at 10:00 a.m., local time, for the following purposes:
1. To elect all of the members of the Company's Board of Directors to
serve until the Company's next annual meeting and until such directors'
successors are elected and shall have qualified.
2. To consider and vote upon an amendment to the Company's Amended and
Restated Certificate of Incorporation to increase the number of authorized
shares of common stock from 300,000,000 to 600,000,000.
3. To consider and vote upon an amendment to the Company's 1999 Stock
Plan to permit options to be granted thereunder to directors of the
Company.
4. To ratify the appointment of Ernst & Young LLP as the Company's
independent auditors for the fiscal year ending December 31, 2000.
5. To transact such other business as may properly come before the Annual
Meeting or at any adjournments thereof.
A proxy statement describing the matters to be considered at the Annual
Meeting is attached to this notice. Only holders of common stock of record at
the close of business on March 17, 2000 are entitled to notice of, and to vote
at, the Annual Meeting and at any adjournments thereof.
By Order of the Board of Directors
Stephen G. Juelsgaard,
Secretary
South San Francisco, California
April 17, 2000
PLEASE COMPLETE, SIGN AND DATE THE ACCOMPANYING PROXY CARD AND RETURN IT
PROMPTLY IN THE ENCLOSED ENVELOPE. THIS WILL INSURE THAT YOUR SHARES ARE
VOTED IN ACCORDANCE WITH YOUR WISHES.
<PAGE>
FOR THE ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON MAY 15, 2000
INFORMATION CONCERNING SOLICITATION AND VOTING
GENERAL
The Board of Directors of Genentech, Inc. ("Genentech," "we," "us" or the
"Company") hereby solicits your proxy for use at the Annual Meeting of
Stockholders to be held on Monday, May 17, 2000 (the "Annual Meeting"), or at
any adjournment or postponement of the Annual Meeting, for the purposes set
forth in the foregoing Notice of Annual Meeting of Stockholders. Copies of
solicitation material will be furnished to brokerage houses, fiduciaries and
custodians to forward to beneficial owners of common stock of Genentech,
par value $0.02 per share, held in their names. The cost of solicitation of
proxies, including expenses in connection with preparing and mailing this
Proxy Statement, will be borne by Genentech. In addition, we will reimburse
brokerage firms and other persons representing beneficial owners of common
stock for their expenses in forwarding solicitation material to such
beneficial owners. Original solicitation of proxies by mail may be
supplemented by telephone, telegram, internet and personal solicitation by
directors, officers or other regular employees of Genentech. No additional
compensation will be paid to directors, officers or other regular employees
for such services. This Proxy Statement and accompanying Proxy Card will be
mailed on or about April 17, 2000 to all stockholders entitled to vote at the
Annual Meeting. In this proxy statement, "common stock" refers to Genentech's
common stock, par value $.02 per share, and "special common stock" refers to
Genentech's callable putable common stock, par value $.02 per share. In
addition, all share and per share data and other information in this
prospectus relating to our common stock and our special common stock gives
effect to our two-for-one split of our common stock on November 2, 1999.
VOTING RIGHTS AND OUTSTANDING SHARES
Stockholders of record at the close of business on March 17, 2000 (the
"Record Date") will be entitled to notice of and to vote at the Annual
Meeting. On the Record Date, Genentech had outstanding 260,349,300 shares of
common stock, par value $0.02 per share. A quorum for the Annual Meeting
consists of a majority of the total number of shares of common stock
outstanding on the Record Date. Each holder of record of shares of common
stock on the Record Date is entitled to one vote per share on each matter to
be considered at the Annual Meeting. The directors are elected by a plurality
of the votes of common stock present in person or by proxy and entitled to
vote at the Annual Meeting. The affirmative vote of a majority of the shares
of common stock issued and outstanding is required for approval of the
amendment of the Company's Amended and Restated Certificate of Incorporation.
An affirmative vote of a majority of the shares present in person or
represented by proxy and entitled to vote is required for approval of all
other matters being submitted to the stockholders for their consideration. All
votes will be tabulated by the inspector of elections appointed for the Annual
Meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker nonvotes. Abstentions and broker nonvotes are each
included in the number of shares present for purposes of determining the
presence of a quorum. However, abstentions will be counted toward the
tabulations of votes cast on proposals presented to the stockholders and will
have the same effect as negative votes. For the amendment of the Company's
Amended and Restated Certificate of Incorporation, a broker nonvote will take
the same effect as a negative vote but on all other matters broker nonvotes
will not be counted for purposes of determining whether a proposal has been
approved or not.
Any stockholder giving a proxy has the power to revoke it any time before it
is exercised, whether the proxy was given by telephone, via the internet or by
returning the Proxy Card. The proxy may be revoked by filing with the
Secretary of Genentech, at the principal executive office of Genentech, 1 DNA
Way, South San Francisco, California 94080, a notice of revocation or a duly
executed Proxy Card bearing a later date, or by making an authorized internet
or telephone communication on a later date in accordance with the instructions
on the enclosed Proxy Card. It may also be revoked by attendance at the Annual
Meeting and voting in person.
1
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RELATIONSHIP WITH ROCHE
History of Ownership
On September 7, 1990, a wholly owned subsidiary of Roche Holdings, Inc.
("Roche") was merged with and into Genentech. Pursuant to the 1990 merger
agreement, Genentech and Roche entered into a governance agreement that
contained terms relating to our corporate governance after the 1990 merger.
Pursuant to the 1990 governance agreement, our board of directors elected two
nominees of Roche to serve on the Genentech board. On October 25, 1995, a
second wholly owned subsidiary of Roche was merged with and into Genentech,
and Genentech and Roche amended the 1990 governance agreement. In the 1995
merger, for our stockholders other than Roche, each share of common stock was
converted into one share of our special common stock. Roche maintained the
same percentage ownership of our equity as prior to the 1995 merger and
continued to have the right to nominate only two directors to our board of
directors under the amended governance agreement. The purpose of the
conversion of the common stock into special common stock was (i) to establish
a four-year period during which our publicly traded stock could be redeemed by
us at Roche's option at specified prices per share ranging from $31.25 during
the quarter ending December 31, 1995 to $41.25 during the quarter ending June
30, 1999 and (ii) to afford the holders of special common stock the right to
require the purchase of all or a portion at the option of the holder of their
shares of such stock at a price of $30.00 per share exercisable during the
30-business day period following June 30, 1999.
Redemption of the Special Common Stock
On June 30, 1999, we redeemed all of our special common stock held by
stockholders other than Roche at $41.25 per share in cash and retired all of
the shares of special common stock including those held by Roche. As a result,
Roche's percentage ownership of our outstanding equity increased from
approximately 65% to 100% and our then existing governance agreement
terminated, except for provisions relating to indemnification and stock
options, warrants and convertible securities.
Offerings of, and Notes Exchangeable for, our Common Stock
On July 23, 1999, Roche completed a public offering of 44 million shares of
our common stock. In connection with that offering, we amended our certificate
of incorporation and bylaws and entered into an affiliation agreement with
Roche, described below. On October 26, 1999, Roche completed a public offering
of 40 million shares of our common stock. Upon completion of that offering,
Roche's percentage ownership of our outstanding common stock was reduced to
66.4%. On January 19, 2000, Roche completed an offering of zero-coupon notes
which are exchangeable for an aggregate of 6,517,309 shares of our common
stock held by Roche. On March 29, 2000, Roche completed a public offering of
17.3 million shares of our common stock, reducing its ownership to 58.9% of
our outstanding common stock.
Arrangements between Genentech and Roche
As a result of the redemption of the special common stock, the then existing
governance agreement between Genentech and Roche terminated, except for
provisions relating to indemnification and stock options, warrants and
convertible securities. Subsequently, we entered into an affiliation agreement
with Roche that enabled our current management to conduct our business and
operations as we had done in the past while at the same time reflecting
Roche's ownership in us. The affiliation agreement is for the exclusive
benefit of Roche and can be amended at any time by Roche and us. We have
amended our bylaws in order to maintain certain proportional representation
rights of Roche under the bylaws with respect to membership on our board of
directors and board committees to the extent that we do not make repurchases
of our common stock as required by the affiliation agreement. We expect that
we and Roche will make similar amendments to the affiliation agreement and
licensing agreement.
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Our certificate of incorporation provides that the provisions in our bylaws
described below under "--Composition of Board of Directors," "--Roche's Right
to Proportional Representation," "--Membership of Committees" and "--
Nomination of Directors" may be repealed or amended only by a 60% vote of our
stockholders, except for Roche's right to nominate a number of directors
proportional to Roche's ownership interest rounded down to the next whole
number until Roche's ownership interest is less than 5%, which may be repealed
or amended only by a 90% vote of our shareholders. The provisions of the
affiliation agreement described below under "--Roche Approval Required for
Certain Actions" and "--Licensing and Marketing Arrangements" terminate upon
Roche owning less than 40% of our stock.
For purposes of the following provisions, an independent director is a
director who is not:
. one of our officers; or
. an employee, director, principal stockholder or partner of Roche or any
affiliate of Roche or an entity that was dependent upon Roche for more
than 10% of its revenues or earnings in its most recent fiscal year.
Composition of Board of Directors
Our board consists of six members all of whom are nominated by the
nominations committee of the Board: two nominees of Roche, one executive
officer of Genentech and up to three independent directors. Directors are
elected to serve one year terms or until their successors are elected and
qualified. At all times our board will include at least two independent
directors and one executive officer of Genentech.
Roche's Right to Proportional Representation
We have agreed that upon Roche's request Roche will be entitled to
representation on our board proportional to its ownership interest in our
common stock. Roche will be entitled to have the number of Roche designated
directors equal to the percentage of our common stock owned by Roche times the
total number of directors, rounded up to the next whole number if Roche's
ownership interest is greater than 50% and rounded down if Roche's ownership
percentage is less than or equal to 50%. Upon Roche's request, we will
immediately take action to cause the size of our board to be increased and to
cause our board to fill the vacancies by electing Roche nominees in order to
achieve Roche's proportional representation. If Roche's ownership interest of
common stock drops below 40%, Roche will cause its directors to resign to the
extent its representation is in excess of its proportional ownership interest.
The number of directors who are required to resign upon such event shall be
rounded up to the next whole number. Roche shall thereafter be entitled to
nominate a number of directors which is proportional to Roche's ownership
interest rounded down to the next whole number, until Roche's ownership
interest is less than 5%.
Membership of Committees
We have five standing committees of the board: an Audit Committee, a
Compensation Committee, a Corporate Governance Committee, an Executive
Committee and a Nominations Committee and Roche is entitled upon request to
its proportional representation on each committee. Roche's committee members
may designate another Roche director to serve as their alternates on any
committee.
The nominations committee shall at all times have three members. At anytime
that Roche owns 80% or more of the total voting power of our stock, the
nominations committee shall include two nominees of Roche and one of the
independent directors. At any time that Roche owns less than 80% of the total
voting power of our stock, the nominations committee shall (1) include a
number of nominees of Roche that is equal to the percentage owned by Roche of
the total voting power of our common stock times three, rounded up to the next
whole number if Roche's total voting power is greater than 50% and rounded
down to the next whole number if Roche's total voting power is less than or
equal to 50% provided that Roche shall at no time have more than two
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<PAGE>
nominees and, provided further that if the reason for Roche owning less than
80% of the total voting power is as result of a breach of our obligations
relating to tax matters below, the nominations committee shall include two
nominees of Roche as determined pursuant to clause (1) above.
Nomination of Directors
The nomination of any person for director requires the approval of a
majority of the members of the nominations committee.
Roche Approval Required for Certain Actions
Without the prior approval of the directors designated by Roche, we have
agreed not to approve:
. any acquisition that would constitute a substantial portion of our
business or assets;
. any sale, lease, license, transfer or other disposal of all or a
substantial portion of our business or assets other than in the ordinary
course of our business;
. any issuance of capital stock except (1) issuances of capital stock
pursuant to employee incentive plans not exceeding 5% of our voting
stock, (2) issuances of capital stock upon the exercise, conversion or
exchange of any of our outstanding capital stock, and (3) other
issuances of capital stock not exceeding 5% of our voting stock in any
24 month period; and
. any repurchase or redemption of our capital stock other than redemption
required by the terms of any security and purchases made at fair market
value in connection with any of our deferred compensation plans.
For purposes of the first and second bullet points in this paragraph, unless
a majority of the board of directors have made a contrary determination in
good faith, a "substantial portion of our business or assets" shall mean a
portion of our business or assets accounting for 10% or more of our and our
consolidated subsidiaries' consolidated total assets, contribution to net
income or revenues.
Following a request by Roche for proportional representation on the board,
until the Roche designees take office as directors we may not take any action
other than in the ordinary course of business without the consent of Roche.
Licensing and Marketing Arrangements
In 1995, we entered into a licensing and marketing agreement with F.
Hoffmann-La Roche Ltd ("Hoffmann-La Roche") and its affiliates granting it a
ten-year option to license to use and sell products in non-U.S. markets. In
July 1999, we amended that agreement, the major provisions of which include:
. extending Hoffmann-La Roche's option until at least 2015;
. Hoffmann-La Roche may exercise its option to license our products upon
the occurrence of any of the following: (1) our decision to file an
Investigational New Drug exemption application, or IND, for a product,
(2) completion of a Phase II trial for a product or (3) if Hoffmann-La
Roche previously paid us a fee of $10 million to extend its option on a
product, completion of a Phase III trial for that product;
. we agreed, in general, to manufacture for and supply to Hoffmann-La
Roche its clinical requirements of our products at cost, and its
commercial requirements at cost plus a margin of 20%; however, Hoffmann-
La Roche will have the right to manufacture our products under certain
circumstances;
. Hoffmann-La Roche has agreed to pay, for each product for which
Hoffmann-La Roche exercises its option upon either a decision to file an
IND with the FDA or completion of the Phase II trials, a royalty of
12.5% on the first $100 million on its aggregate sales of that product
and thereafter a royalty of
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<PAGE>
15% on its aggregate sales of that product in excess of $100 million
until the later in each country of the expiration of our last relevant
patent or 25 years from the first commercial introduction of that
product; and
. Hoffmann-La Roche will pay, for each product for which Hoffmann-La Roche
exercises its option after completion of the Phase III trials, a royalty
of 15% on its sales of that product until the later in each country of
the expiration of our relevant patent or 25 years from the first
commercial introduction of that product; however, $5 million of any
option extension fee paid by Hoffmann-La Roche will be credited against
royalties payable to us in the first calendar year of sales by Hoffmann-
La Roche in which aggregate sales of the product exceed $100 million.
Registration Rights
We have agreed that, upon Roche's request, we will file one or more
registration statements under the Securities Act in order to permit Roche to
offer and sell shares of our common stock. We have agreed to use our best
efforts to facilitate the registration and offering of those shares designated
for sale by Roche.
We have the right to postpone the filing or effectiveness of a registration
statement for a period of up to 60 days in any 12-month period if:
. in the reasonable good faith judgment of our board, fulfillment of our
obligations would require us to make disclosures that would be
detrimental to Genentech and premature; or
. we have filed a registration statement with respect to securities to be
distributed in an underwritten public offering and we have been advised
by the lead or managing underwriter that an offering by Roche would
materially and adversely affect the distribution of our securities.
Generally, all expenses incident to the performance by us of our obligations
with respect to the registration of Roche's shares of our common stock will be
paid by us except that Roche has agreed to pay certain expenses to be directly
incurred by Roche, including underwriting fees, discounts and commissions and
counsel fees. In addition, we are only required to pay for two registrations
within a 12-month period. We and Roche each have agreed to customary
indemnification and contribution provisions with respect to liability incurred
in connection with these registrations.
Dispositions by Roche
If Roche and its affiliates sell their majority ownership of shares of our
common stock to a successor, Roche has agreed that it will cause the successor
to purchase all shares of our common stock not held by Roche:
. if the consideration is composed entirely of either cash or equity
traded on a U.S. national securities exchange, with consideration in the
same form and amounts per share as received by Roche and its affiliates;
and
. in any other case, with consideration either in the same form and
amounts per share as received by Roche and its affiliates or with
consideration that has a value per share not less than the weighted
average value per share received by Roche and its affiliates as
determined by an investment bank of nationally recognized standing
appointed by a committee of independent directors.
Roche has agreed to cause the buyer to agree to be bound by the obligations
described in the preceding paragraph as well as the obligations described
under "--Business Combinations with Roche" and "--Compulsory Acquisitions"
below. We have agreed that the buyer shall be entitled to succeed to Roche's
rights described under "--Roche's Right to Proportional Representation."
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Business Combinations with Roche
Roche has agreed that as a condition to any merger of Genentech with Roche
or its affiliates or the sale of substantially all of our assets to Roche or
its affiliates, that either:
. the merger or sale must be authorized by the favorable vote at any
meeting of a majority of the shares of common stock not owned by Roche,
provided that no person or group shall be entitled to cast more than 5%
of the votes cast at the meeting; or
. in the event such a favorable vote is not obtained, the value of the
consideration to be received by the holders of our common stock, other
than Roche, shall be equal to or greater than the average of the means
of the ranges of fair values for the common stock as determined by two
investment banks of nationally recognized standing appointed by a
committee of independent directors.
Roche has agreed that it will not sell any shares of our common stock in the
90 days immediately preceding any proposal by Roche for a merger with us.
Roche also agreed that in the event of any merger of Genentech with Roche or
its affiliates or sale of substantially all of our assets to Roche or its
affiliates, each unvested option then outstanding under our stock option plan
will:
. be accelerated so that each option shall become exercisable immediately
prior to the consummation of the transaction for the full number of
shares of common stock covered by the option;
. become exchangeable upon the consummation of the transaction for
deferred cash compensation, which vests on the same schedule as the
shares of the common stock covered by the option, having a value equal
to the product of (A) the number of shares covered by the option and (B)
the amount which Roche, in its reasonable judgment, considers to be
equivalent in value to the consideration per share received by holders
of shares of common stock other than Roche in the transaction, minus the
exercise price per share under the option; or
. be canceled in exchange for a replacement option to purchase stock of
the surviving corporation in the transaction with the terms of the
option to provide value equivalent, as determined by Roche in its
reasonable discretion, to that of the canceled option.
Compulsory Acquisitions
If Roche owns more than 90% of our common stock for more than two months,
Roche has agreed to, as soon as reasonably practicable, effect a merger of
Genentech with Roche or an affiliate of Roche.
The merger shall be conditioned on the vote or the valuation described under
the first two bullets of "--Business Combinations with Roche" above.
Roche's Right to Maintain its Percentage Ownership Interest in Our Stock
The affiliation agreement requires us to, among other things, establish a
stock repurchase program designed to maintain Roche's percentage ownership
interest in our common stock. We are required to repurchase a sufficient
number of shares pursuant to this program to ensure that, with respect to any
issuance of common stock by us in the future, the percentage of our common
stock owned by Roche immediately after such issuance will be no lower than
Roche's lowest percentage ownership of our common stock at any time after the
offering of common stock occurring in July 1999 but prior to the time of such
issuance, except that we may issue shares up to an amount that would cause
Roche's lowest percentage ownership to be no more than 2% below the "Minimum
Percentage." The Minimum Percentage equals a fraction (expressed as a
percentage) where the numerator is the lowest number of shares of our common
stock owned by Roche since the July 1999 offering (to be adjusted in the
future for dispositions of shares of our common stock by Roche, including the
March 29, 2000 offering), and the denominator is 254,597,176, which is the
number of shares of our common stock outstanding
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<PAGE>
at the time of the July 1999 offering adjusted for the two-for-one split of
our common stock in November 1999. Each of the numerator and denominator are
to be adjusted in the future for stock splits or stock combinations. As long
as Roche's percentage ownership is greater than 50%, prior to issuing any
shares, we must repurchase a sufficient number of shares of our common stock
to ensure that, immediately after its issuance of shares, Roche's percentage
ownership will be greater than 50%. We have also agreed, upon Roche's request,
to repurchase shares of our common stock to increase Roche's ownership to the
Minimum Percentage. Roche currently owns approximately 58.9% of our common
stock following completion of the March 29, 2000 offering. In addition, we are
required to provide information to Roche each month, or more frequently if
requested, regarding the status of the repurchase program and previous and
expected future issuances of common stock by us, and we also will be obligated
to notify Roche the day after the number of shares of common stock issued in a
month equals or exceeds 500,000. Our obligations with respect to this stock
repurchase program will terminate upon Roche owning less than 40% of our
stock.
Furthermore, Roche has (i) a continuing option (which is assignable by Roche
to any of its affiliates) to buy from us, prior to the occurrence of any event
that could result in a decrease in the percentage of common stock owned by
Roche and its affiliates, a sufficient amount of common stock to ensure that
Roche and its affiliates maintain the percentage ownership of our common stock
owned by them, and (ii) a continuing option (which is assignable by Roche to
any of its affiliates) to buy from us 80% of any class of stock issued by us
other than common stock, in each case with a price per share equal to either
the average of the last sale price on each of the five immediately preceding
trading days on a U.S. national securities exchange on which the shares are
traded or, if the sale prices are unavailable, the value of the shares
determined in accordance with procedures reasonably satisfactory to Roche and
us.
These provisions of the affiliation agreement may have the effect of
limiting our ability to use our capital stock as consideration for
acquisitions.
Tax Sharing Agreement
From the redemption of our special common stock in June 1999 until Roche
completed its public offering of our common stock in October 1999, we were
included in Roche's U.S. consolidated federal income tax group and included
with Roche and/or one or more Roche subsidiaries in consolidated or combined
income tax groups for certain state and local tax jurisdictions. Accordingly,
we entered into a tax sharing agreement with Roche. Pursuant to the tax
sharing agreement, we and Roche are to make payments such that the net amount
paid by us on account of consolidated or combined income taxes is determined
as if we had filed separate, stand-alone federal, state and local income tax
returns as the common parent of an affiliated group of corporations filing
consolidated or combined federal, state and local returns.
Effective upon the consummation of the public offering in October 1999, we
ceased to be a member of the consolidated federal income tax group (and
certain consolidated or combined state or local income tax groups) of which
Roche is the common parent. Accordingly, our tax sharing agreement with Roche
now pertains only to the state and local tax returns in which we will be
consolidated or combined with Roche. We will continue to calculate our tax
liability or refund with Roche for these state and local jurisdictions as if
we were a stand-alone entity.
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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS
The following table sets forth as of December 31, 1999, certain information
regarding all stockholders known by Genentech to be the beneficial owners of
more than five percent of any class of Genentech's voting securities,
according to Securities and Exchange Commission filings pursuant to Section
13(d) and Section 13(g) of the Securities Exchange Act of 1934, as amended:
<TABLE>
<CAPTION>
Name and Address of Beneficial Number of
Owner Shares Class Percent of Class
------------------------------ ----------- ----- ----------------
<S> <C> <C> <C>
Roche Holdings, Inc.............. 170,597,176 Common Stock 66.1%
One Commerce Center, Suite 1050
Wilmington, DE 19801
FMR Corp. ....................... 15,003,066(1) Common Stock 5.81%
82 Devonshire Street
Boston, MA 02109
</TABLE>
- --------
(1) Includes 14,560,180 shares, or 5.64% of the class, beneficially owned as
of December 31, 1999 by Fidelity Management & Research Company, a wholly-
owned subsidiary of FMR Corp., as a result of acting as an investment
advisor to various investment companies.
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PROPOSAL 1--ELECTION OF DIRECTORS
NOMINEES
The Company's Board consists of two Roche directors, Franz B. Humer and
Jonathan K.C. Knowles, three independent directors, Herbert W. Boyer, Charles
A. Sanders and Sir Mark Richmond, and one Genentech employee, Arthur D.
Levinson, who is also the chairman of the board. Each of these individuals is
being nominated for election at the Annual Meeting for a one year term
expiring on the date of the Annual Meeting in 2001 or until each such
director's successor shall have been duly elected or appointed. It is intended
that the shares represented by proxies will be voted for the election of all
the nominees, unless the proxy withholds authority to vote for any of them.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR EACH NOMINEE
In the event any of such nominees becomes unable or unwilling to serve, the
shares represented by the proxies will be voted for the election of the
balance of those named and such other person as the Board of Directors may
select. The Board of Directors has no reason to believe that any such nominee
will be unable to serve.
The following table sets forth the name and age (as of the date of the
Annual Meeting) of each of the directors, their principal occupations at
present, the positions and offices held by each with Genentech in addition to
the position as a director, and the period during which each has served as a
director of Genentech.
<TABLE>
<CAPTION>
Served as
Principal Occupation / Director
Name Age Position Held Since
---- --- ---------------------- ---------
<C> <C> <S> <C>
Herbert W. Boyer, Ph.D. ....... 63 Director of Genentech 1976
Franz B. Humer, Ph.D. ......... 53 Chief Executive Officer and
Head of the Pharmaceuticals
Division, The Roche Group 1995
President of Global
Jonathan K.C. Knowles, Ph.D. .. 52 Research, The Roche Group 1998
Arthur D. Levinson, Ph.D. ..... 50 Chairman, President and
Chief Executive Officer of
Genentech 1995
Sir Mark Richmond, Ph.D. ...... 69 Sr. Research Fellow, School
of Public Policy at
University College, London 1999
Charles A. Sanders, M.D. ...... 68 Director of Genentech 1999
</TABLE>
Dr. Boyer, a founder of Genentech, had been a director of Genentech from
1976 when he resigned from the Board in connection with the redemption of our
callable putable common stock. He was reelected to the Board in September
1999. Dr. Boyer is a consultant to Genentech. He served as a Vice President of
Genentech from 1976 to 1991. Dr. Boyer, a Professor of Biochemistry at the
University of California at San Francisco from 1976 to 1991, demonstrated the
usefulness of recombinant DNA technology to produce medicines economically,
which laid the groundwork for Genentech's development. In 1993, Dr. Boyer
received the 1993 Helmut Horten Research Award. He also received the National
Medal of Science from President Bush in 1990, the National Medal of Technology
in 1989 and the Albert Lasker Basic Medical Research Award in 1980. He is an
elected member of the National Academy of Sciences and a Fellow in the
American Academy of Arts and Sciences. In addition, Dr. Boyer serves as
Chairman of the Board of Directors of Allergan, Inc.
Dr. Humer joined The Roche Group in the spring of 1995 as the Head of its
Pharmaceuticals Division and became Chief Executive Officer of The Roche Group
in January 1998. He is also a member of the Board of Directors and Chairman of
the Executive Committee of The Roche Group. Prior to joining The Roche Group,
Dr. Humer was an Executive Director and Chief Operating Officer of Glaxo
Holdings, a United Kingdom public limited company. Dr. Humer also serves as a
director of Cadbury Schweppes p.l.c. Pursuant to the affiliation agreement,
Dr. Humer is a designee of Roche.
9
<PAGE>
Dr. Knowles joined The Roche Group as President of Global Research in
September 1997. In January 1998, he became a member of the Executive Committee
of The Roche Group. Prior to joining The Roche Group, Dr. Knowles served as
the Director of Research for Europe of Glaxo from 1995 and served as the
Director of the Geneva Institute of Glaxo from 1989 to 1995. Pursuant to the
affiliation agreement, Dr. Knowles is a designee of Roche.
Dr. Levinson was appointed Chairman of the Board of Directors on September
1999 and was elected President and Chief Executive Officer and a director of
the Company in July 1995. Since joining the Company in 1980, Dr. Levinson has
been a Senior Scientist, Staff Scientist and the Director of the Company's
Cell Genetics Department. Dr. Levinson was appointed Vice President of
Research Technology in April 1989, Vice President of Research in May 1990 and
Senior Vice President in January 1993. Dr. Levinson was formerly on the
editorial boards of "Molecular Biology and Medicine" and "Molecular and
Cellular Biology," and is active in the American Society of Microbiology, the
New York Academy of Sciences, the American Association for the Advancement of
Science, and the American Society for Biochemistry and Molecular Biology. From
1977 to 1980, Dr. Levinson was a Postdoctoral Fellow in the Department of
Microbiology at the University of California, San Francisco. In 1977, Dr.
Levinson received his Ph.D. in Biochemistry from Princeton University.
Dr. Richmond was elected a director of Genentech in August 1999. He has been
a senior research fellow at the School of Public Policy, University College
London since February 1996. Previously, he held positions as science advisor
at Glaxo Wellcome plc from 1995 to February 1996, as Group Head of Research at
Glaxo plc from 1993 to 1995, as chairman of the Science and Engineering
Council, London, from 1990 to 1993, as vice chancellor at the University of
Manchester from 1981 to 1990, and professor and head of the Department at
Bacteriology at the University of Bristol from 1968 to 1981. Sir Mark is
currently a member of the Scientific Advisory Committee of the Institute for
Biotechnology, ETH, Zurich, a member of the Scientific Advisory Board of the
SPP-Biotechnology, Swiss National Foundation and a member of the Board of
Directors of Target Genetics.
Dr. Sanders was elected a director of Genentech in August 1999. He served as
Chief Executive Officer of Glaxo Inc. from 1989 to 1994, and was the Chairman
of the Board of Glaxo Inc. from 1992 to 1995. He also has served on the Board
of Directors of Glaxo plc. Previously, he held a number of positions at Squibb
Corporation, a multinational pharmaceutical corporation, including Vice
Chairman, Chief Executive Officer of the Science and Technology Group and
Chairman of the Science and Technology Committee on the Board. Dr. Sanders is
a member of the Boards of Directors of Scios Inc., Magainin Pharmaceuticals,
Vertex Pharmaceuticals, StaffMark, Inc., Kendle International Inc., Trimeris,
Inc., Biopure Corporation and Pharmacopeia, Inc.
COMMITTEES AND MEETINGS
During 1999, the Board of Directors held six meetings, the Audit Committee
held four meetings, the Compensation Committee held three meetings, the
Corporate Governance Committee held two meetings, the Executive Committee held
six meetings by consent and the Nominations Committee held one meeting. All of
the directors attended at least 75% of the aggregate meetings of the Board and
the committees of which he is a member except Dr. Knowles who did not attend
two Board meetings, two Compensation Committee meetings, and two Corporate
Governance Committee meetings.
The Audit Committee currently consists of Drs. Boyer, Richmond and Sanders,
none of whom is an employee of Genentech. The Audit Committee recommends the
independent auditors to the Board and provides a direct line of communication
between the auditors and the Board. The Audit Committee, with and without
Company management present, meets with the Company's independent auditors to
review and discuss various matters, including Genentech's financial
statements, the quarterly reporting process and management's control thereof,
the inventory and receivable reserve policies, the tax compliance program and
strategy, the scope of external and general audit activities, the independent
auditor's fees and performance, the Company's investment policy and risk
management programs, the report of the independent auditors and accompanying
management
10
<PAGE>
letter on the scope and results of their work and their recommendations
concerning Genentech's financial practices and procedures.
The Compensation Committee currently consists of Drs. Boyer, Humer, Knowles,
Richmond and Sanders, none of whom is an employee of Genentech. The
Compensation Committee administers Genentech's stock option plans, the stock
purchase plan and other corporate benefits programs. The Compensation
Committee also reviews and approves the annual bonus plan, bonus plan payouts,
annual stock option grants, the corporate benefits strategy, incentive plan
status, compensation philosophy and current competitive status, and executive
officer compensation. In addition, the Compensation Committee recommends
executive officers of the Company for election as executive officers by the
Board of Directors.
The Corporate Governance Committee currently consists of Drs. Knowles,
Richmond and Sanders. The Corporate Governance Committee reviews the Company's
sales and marketing policies and compliance, investor relations, corporate
communications, government relations, human resources, legal and regulatory
affairs, compliance with laws and regulations, and Board of Directors and
Board committee effectiveness.
The Executive Committee currently consists of Drs. Levinson, Humer and
Boyer. The Executive Committee was established to act when the full Board of
Directors is unavailable. It has all the authority of the Board in the
management of the business and affairs of Genentech, except those powers that
by law cannot be delegated by the Board of Directors.
The Nominations Committee currently consists of Drs. Knowles, Humer and
Boyer. The purpose of the Nominations Committee is to identify, review and
recommend potential nominees to the Board of Directors of Genentech, and to
recommend executive officers of the Company for election as executive officers
by the Board of Directors. The Nominations Committee will consider nominees to
the Board of Directors recommended by Genentech stockholders. To be
considered, stockholders wishing to nominate a person to the Board of
Directors should send a letter to the Secretary of Genentech. Any
stockholder's notice regarding director nominations must set forth: (a) the
name and address of the stockholder who intends to make the nomination and of
the person or persons to be nominated, (b) a representation that the
stockholder is a holder of record of stock of the Company entitled to vote at
such meeting and intends to appear in person or by proxy at the meeting to
nominate the person or persons specified in the notice, (c) a description of
all arrangements or understandings between the stockholder and each nominee
and any other person or persons (naming such person or persons) pursuant to
which the nomination or nominations are to be made by the stockholder, (d)
such other information regarding each nominee proposed by such stockholder as
would be required to be included in a proxy statement filed pursuant to the
proxy rules of the Securities and Exchange Commission had the nominee been
nominated, or intended to be nominated, by the Board of Directors, and (e) the
consent of each nominee to serve as a director of the corporation if so
elected.
11
<PAGE>
PROPOSAL 2--AMENDMENT OF COMPANY'S AMENDED AND RESTATED
CERTIFICATE OF INCORPORATION
On February 9, 2000, the Board of Directors unanimously adopted a resolution
approving an amendment to the Company's Amended and Restated Certificate of
Incorporation to increase the number of authorized shares of common stock from
300,000,000 to 600,000,000. Each additional share of common stock will have
the same rights and privileges as each share of currently authorized common
stock. This amendment requires the approval of the Company's stockholders. As
amended, the relevant Section of Article 4 of the Company's Amended and
Restated Certificate of Incorporation will read as follows:
Section 4.01. Capital Stock. (a) The Corporation is authorized to issue
two classes of stock to be designated, respectively, preferred stock and
common stock. The total number of shares which the Corporation is
authorized to issue is seven hundred million (700,000,000) shares. One
hundred million (100,000,000) shares shall be designated preferred stock,
par value $0.02 per share ("Preferred Stock"). Six hundred million
(600,000,000) shares shall be designated common stock, par value $0.02 per
share ("Common Stock"). The common stock of the Corporation shall be all of
one class.
(b) The number of authorized shares of any class or classes of stock may
be increased or decreased (but not below the number of shares thereof then
outstanding) by the affirmative vote of a majority in voting power of the
outstanding stock of the Corporation entitled to vote thereon irrespective
of the provisions of Section 242(b)(2) of Delaware Law.
In November 1999, a two-for-one stock split was effected by the issuance of
additional shares of common stock as a stock dividend to stockholders. This
action was taken to facilitate ownership of common stock and to bring the
market price of the common stock within a trading range more attractive to
independent investors. The Board of Directors believes it is in the best
interests of the Company to increase the number of authorized shares in order
to give the Company greater flexibility in considering and planning for future
business needs. The shares will be available for issuance by the Board of
Directors for proper corporate purposes, including but not limited to, stock
dividends, stock splits, acquisitions, financings and compensation plans.
The issuance of additional shares of common stock, other than in connection
with stock splits and stock dividends, could have the effect of diluting
earnings per share, voting power and shareholdings of stockholders. It could
also have the effect of making it more difficult for a third party to acquire
control of the Company. Other than in connection with the Company's existing
employee stock option and stock purchase plans, the Company has no present
intent to issue any shares of common stock. Current stockholders do not have
preemptive rights to subscribe for, purchase or reserve any shares of the
authorized capital stock of the Company.
If the amendment is approved, the Amended and Restated Certificate of
Incorporation will be filed with the Secretary of State of Delaware as soon as
practicable after the meeting.
The affirmative vote of the holders of a majority of the number of shares of
common stock outstanding is required for approval of this proposal.
The Board of Directors unanimously recommends that stockholders vote "FOR"
approval of the amendment to the Amended and Restated Certificate of
Incorporation.
12
<PAGE>
PROPOSAL 3--AMENDMENT OF 1999 STOCK PLAN
On July 16, 1999, the Board of Directors and Roche, then the Company's sole
stockholder, approved the 1999 Stock Plan. Also effective that date, options
to purchase approximately 13 million shares were granted to approximately
2,400 employees at an exercise price of $48.50 per share. Approximately 4,000
employees are eligible to receive grants under the 1999 Stock Plan. During
1999, all executive officers as a group received options under the 1999 Stock
Plan to purchase approximately 4.1 million shares in replacement of unvested
options that were canceled in connection with Roche's redemption of
Genentech's outstanding common stock in June 1999. See page 19 for information
with regard to 1999 grants to the 5 named executive officers listed on page
18.
The 1999 Stock Plan provides for the grant of non-statutory options and
incentive stock options. An aggregate of 24 million shares is reserved for
issuance under the 1999 Stock Plan and as of the Record Date approximately 8
million shares are available for future grants under such plan. The exercise
price of the options granted under the 1999 Stock Plan will not be less than
100% of the fair market value of the shares of common stock on the date of
grant of these options. In general, options granted under the 1999 Stock Plan
will have a term of ten years.
On November 30, 1999, the Board of Directors approved an amendment to the
1999 Stock Plan to permit independent directors of the Company to receive
option grants under such plans. Under the 1999 Stock Plan, as amended, the
Board of Directors will have the authority to determine the time of grant and
the size of each grant. At the current time, it is anticipated that a grant
will be made each year at the time of the Company's annual meeting of
stockholders.
The Board of Directors believes this amendment will enhance the Company's
ability to attract and retain directors of exceptional quality and is in the
best interest of stockholders.
Attached as Exhibit A is an excerpt of the 1999 Stock Plan showing the
language to be amended.
Federal Tax Consequences of the 1999 Stock Plan
The following is intended only as a general summary of the federal income
tax consequences in connection with options granted under the 1999 Stock Plan.
All tax matters discussed in this Proxy Statement should be verified with a
tax consultant.
The grant of an incentive stock option will have no immediate tax
consequences to the optionee or to the company. The exercise of an incentive
stock option by the payment of cash to the Company will generally have no
immediate tax consequences to the optionee (except to the extent it is an
adjustment in computing alternative minimum taxable income) or to the Company.
If an optionee holds the shares acquired pursuant to the exercise of an
incentive stock option for the required holding period, the optionee generally
will realize long-term capital gain or long-term capital loss upon a
subsequent sale of the shares in the amount of the difference between the
amount realized upon the sale and the purchase price of the shares (i.e., the
exercise price). In such case, no deduction will be allowable to the Company
in connection with the grant or exercise of the incentive stock option or the
sale of shares of common stock acquired pursuant to such exercise.
If, however, an optionee disposes of the shares prior to the expiration of
the required holding period (a "disqualifying disposition"), the optionee will
recognize ordinary income (and the Company will generally be entitled to a
deduction) equal to the excess of the fair market value of the shares of
common stock on the date of exercise (or the proceeds of the disposition, if
less) over the exercise price. Special rules apply in the event all or a
portion of the exercise price is paid in the form of stock.
The grant of a stock option other than an incentive stock option (a "non-
qualified stock option") will have no immediate tax consequences to the
optionee or to the Company. Upon the exercise of a non-qualified stock option,
the optionee will generally recognize ordinary income (and the Company will
generally be entitled to a deduction) in an amount equal to the excess of the
fair market value of the shares of common stock on the date of the exercise of
the option over the exercise price. The optionee's tax basis in the shares
will be the exercise
13
<PAGE>
price plus the amount of ordinary income recognized by the optionee, and the
optionee's holding period will commence on the date the shares are
transferred. Special rules apply in the event all or a portion of the exercise
price is paid in the form of stock.
Upon a subsequent sale of shares of common stock acquired pursuant to the
exercise of a non-qualified stock option, any difference between the
optionee's tax basis in the shares and the amount realized on the sale is
treated as long-term capital gain or loss, depending on the holding period of
the shares.
The affirmative vote of the holders of a majority of the common stock
represented at the Annual Meeting is required for the approval of this
proposal.
The Board of Directors unanimously recommends that stockholders vote "FOR"
approval of the amendment to the Company's 1999 Stock Plan.
14
<PAGE>
SECURITY OWNERSHIP OF MANAGEMENT
The following table sets forth the beneficial ownership of shares of common
stock and of the equity securities of Roche Holding Ltd as of March 17, 2000,
unless otherwise noted, of (i) each director of Genentech, (ii) Genentech's
Chief Executive Officer, (iii) each of Genentech's four other most highly
compensated executive officers (together with Genentech's Chief Executive
Officer, the "Named Executive Officers"), and (iv) all directors and executive
officers of Genentech as a group. All Genentech stock numbers reflect the two-
for-one stock split that was effective November 2, 1999.
AMOUNT AND NATURE OF BENEFICIAL OWNERSHIP
<TABLE>
<CAPTION>
Equity Securities Of
Genentech Common Stock Roche Holding Ltd
----------------------------- -----------------------
Name of Beneficial Owner Shares Percent of Class Shares Percent of Class
- ------------------------ --------- ---------------- ------ ----------------
<S> <C> <C> <C> <C>
Herbert W. Boyer,
Ph.D. ................. 400 * 0 0
Susan D. Desmond-
Hellmann, M.D.,
M.P.H. ................ 104,990(1) * 0 0
Dennis J. Henner,
Ph.D. ................. 47,370(2) * 0 0
Franz B. Humer,
Ph.D.(5)............... 0 * 50 **
Stephen G. Juelsgaard... 112,653(3) * 0 0
Jonathan K. C. Knowles,
Ph.D.(5)............... 0 * 0 0
Louis J. Lavigne, Jr. .. 121,710(4) * 0 0
Arthur D. Levinson,
Ph.D. ................. 511,511(5) * 0 0
Sir Mark Richmond,
Ph.D. ................. 0 * 0 0
Charles A. Sanders,
M.D. .................. 0 * 0 0
All Directors and
Executive Officers as a
Group (29 persons)..... 1,497,087(6) * 50 **
</TABLE>
Asterisk (*) indicates that the amount beneficially owned is less than one
percent (1%) of the outstanding shares of common stock.
A double asterisk (**) indicates that the amount beneficially owned is less
than one percent (1%) of the outstanding equity securities of Roche Holding
Ltd.
- --------
(1) Includes stock options currently exercisable or exercisable within 60 days
to purchase 104,598 shares of common stock.
(2) Includes stock options currently exercisable or exercisable within 60 days
to purchase 46,921 shares of common stock.
(3) Includes stock options currently exercisable or exercisable within 60 days
to purchase 112,204 shares of common stock.
(4) Includes stock options currently exercisable or exercisable within 60 days
to purchase 121,635 shares of common stock.
(5) Includes stock options currently exercisable or exercisable within 60 days
to purchase 510,648 shares of common stock.
(6) Includes stock options held by 19 other executive officers that are
currently exercisable or exercisable within 60 days to purchase 1,484,974
shares of common stock.
15
<PAGE>
SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
Section 16(a) of the Exchange Act requires the Company's directors, officers
and persons who own more than 10% of any class of the Company's equity
securities (collectively, "Reporting Persons") to file reports of ownership
and changes in ownership of such securities. Reporting Persons are required by
Securities and Exchange Commission regulations to furnish the Company with
copies of all Section 16(a) reports they file. The Company believes that all
Forms 3, 4 and 5 required to be filed by its directors, officers and greater
than 10% shareholders were filed on time during 1999, except Dr. Boyer who
inadvertently failed to report a purchase of 400 shares in July, 1999 when he
was not a director and timely file a Form 3 upon his again becoming a director
in September, 1999. Both filings were subsequently made in February, 2000.
16
<PAGE>
EXECUTIVE COMPENSATION
COMPENSATION OF DIRECTORS
Each of the directors of Genentech, except Dr. Levinson, are paid an annual
retainer of $30,000. Dr. Levinson is not paid for his services as a director.
In addition, the directors, with the exception of Dr. Levinson, receive a
total of $1,500 for each Board and committee meeting at which the director was
present in person and a total of $500 for each Board and committee meeting at
which the director was present by telephone. All directors are reimbursed for
expenses incurred in connection with their service on the Board. Dr. Boyer
also serves as a consultant to Genentech and received no compensation for his
services as a consultant in 1999. Drs. Boyer, Richmond and Sanders each
received an option to purchase 10,000 shares of common stock as additional
compensation.
In 1992, the Company established a Directors' Charitable Award Program (the
"Award Program") to acknowledge the service of directors to the Company. This
program was discontinued in September, 1999 but life insurance previously
purchased on the life of Donald L. Murfin, a former director, remains in
effect. The Award Program is funded by life insurance policies purchased by
the Company that provide for a $1 million death benefit. Upon the death of the
covered director, the Company may donate $200,000 per year for five years to
up to four educational institutions or nonprofit organizations recommended by
the director, provided that any such institution or organization is approved
by the Company in the year of the donation. Individual directors derived no
financial benefit from the Award Program since all available insurance
proceeds and tax deductions accrue solely to the Company.
17
<PAGE>
COMPENSATION OF EXECUTIVE OFFICERS
SUMMARY OF COMPENSATION
The following table shows for the fiscal years ended December 31, 1999, 1998
and 1997, certain compensation paid by Genentech to the Named Executive
Officers, including salary, bonuses, stock options and certain other
compensation:
SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>
Long Term
Annual Compensation Compensation
------------------------------- Awards
Other Annual Securities
Name And Principal Compensation Underlying All Other
Position Year Salary(1) Bonus (2) Options(3)(#) Compensation
------------------ ---- --------- -------- ------------ ------------- ------------
<S> <C> <C> <C> <C> <C> <C>
Arthur D. Levinson,
Ph.D. ................. 1999 $750,000 $985,000 -- 966,426 $68,000(4)
Chairman, President and
Chief 1998 $650,000 $950,000 -- 700,000 $41,600(4)
Executive Officer 1997 $650,000 $390,000 -- 0 $37,000(4)
Susan D. Desmond-
Hellmann, M.D.,
M.P.H. ................ 1999 $375,200 $400,000 -- 466,552 $27,400(4)
Executive Vice
President, 1998 $310,000 $310,000 -- 300,000 $18,400(4)
Development and Product 1997 $275,000 $150,000 -- 100,000 $15,800(4)
Operations and Chief
Medical
Officer
Louis J. Lavigne, Jr. .. 1999 $367,500 $310,000 -- 419,896 $27,100(4)
Executive Vice
President and 1998 $350,000 $310,000 -- 300,000 $21,400(4)
Chief Financial Officer 1997 $350,000 $185,000 -- 0 $20,400(4)
Stephen G. Juelsgaard... 1999 $295,000 $239,000 -- 259,936 $20,000(4)
Senior Vice President,
General 1998 $263,540 $205,000 -- 160,000 $15,542(4)
Counsel and Secretary 1997 $250,000 $125,000 -- 0 $13,150(4)
Dennis J. Henner,
Ph.D. ................. 1999 $295,000 $200,000 -- 339,916 $19,800(4)
Senior Vice President,
Research 1998 $271,980 $200,000 -- 240,000 $16,079(4)
1997 $262,500 $130,000 -- 0 $15,300(4)
</TABLE>
- --------
(1) Includes amounts earned but deferred at the election of the executive,
such as salary deferrals under Genentech's Tax Reduction Investment Plan
(the "401(k) Plan") established under Section 401(k) of the Internal
Revenue Code of 1986, as amended (the "Code").
(2) As permitted by rules promulgated by the Securities and Exchange
Commission ("SEC"), no amounts are shown with respect to certain
"perquisites" (such as imputed interest on loans at below market value
rates), where such amounts do not exceed the lesser of (i) 10% of the sum
of the amounts of Salary and Bonus for the Named Executive Officer, or
(ii) $50,000.
(3) Genentech has awarded no stock appreciation rights ("SARs").
(4) Consists of Genentech's matching payments under its 401(k) Plan and
Supplemental Plan for 1999, 1998 and 1997. Each of the Named Executive
Officers received $6,400 in matching payments under the 401(k) Plan for
1999 and 1998, and under the Supplemental Plan, Dr. Levinson, Dr. Desmond-
Hellmann, Messrs. Lavigne and Juelsgaard and Dr. Henner received matching
payments of $61,600, $21,000, $20,700, $13,600 and $13,400, respectively,
for 1999 and of $35,200, $12,000, $15,000, $9,142 and $9,679,
respectively, for 1998. Each of the Named Executive Officers received
$6,333 in matching payments under the 401(k) Plan for 1997, and under the
Supplemental Plan, Dr. Levinson, Dr. Desmond-Hellmann, Messrs. Lavigne and
Juelsgaard and Dr. Henner received matching payments of $30,667, $9,467
$14,067, $6,817, and $8,967 respectively, for 1997.
18
<PAGE>
STOCK OPTION GRANTS AND EXERCISES
OPTION GRANTS IN LAST FISCAL YEAR
<TABLE>
<CAPTION>
Individual Grants
-------------------------------------------------------------------------
Percent of
Number of Total Options Grant Date
Securities Underlying Granted to Exercise or Present
Options Granted Employees in Base Price Expiration Value(5)
Name (#)(1) Fiscal Year(2) ($/SH)(3) Date(4) (in millions)
---- --------------------- -------------- ----------- ---------- -------------
<S> <C> <C> <C> <C> <C>
Arthur D. Levinson,
Ph.D. ................. 966,426 5.68% $48.50 07/16/09 $24.4
Susan D. Desmond-
Hellmann,
M.D., M.P.H. .......... 466,552 2.74% $48.50 07/16/09 $11.8
Louis J. Lavigne, Jr. .. 419,896 2.47% $48.50 07/16/09 $10.6
Stephen G. Juelsgaard... 259,936 1.53% $48.50 07/16/09 $ 6.6
Dennis J. Henner,
Ph.D. ................. 339,916 2.00% $48.50 07/16/09 $ 8.6
</TABLE>
- --------
(1) We granted these options pursuant to the 1999 Stock Plan in replacement of
unvested options that were canceled in connection with Roche's redemption
of Genentech's outstanding common stock in June 1999. These options vest
ratably on a monthly basis during the 36-month period following the grant
date. See additional information on page 20 and 21 relating to the
redemption and option transactions.
(2) Based on a total of approximately 17 million options granted under our
1999 Stock Plan to employees, including the Named Executive Officers.
(3) The exercise price per share of options granted represented the offering
price of the Company's public offering in July, 1999.
(4) These options have a term of ten years subject to earlier termination upon
the occurrence of certain events related to termination of employment.
(5) Present value was determined under the Black-Scholes option pricing model
based on the following assumptions: expected volatility of 45%
(representing the annual variance in the monthly change in the price of
selected top-tier biotechnology companies over the prior 10-year period;
used as a proxy for the expected monthly volatility of the Genentech
stock); a risk free rate of 6.01% determined by the remaining life of each
option. Each option is valued at its exercise price, which is assumed to
be equivalent to the market price at the date of grant. This valuation
model was not adjusted for the vesting restrictions or the risk of
forfeiture of the options. Under SFAS 123, forfeitures may be estimated or
assumed to be zero; in this model, the forfeiture rate was assumed to be
zero. Our use of this model in accordance with rules adopted by the
Securities and Exchange Commission does not constitute an endorsement of
the model nor an acknowledgment that such model can accurately determine
the value of options. The valuation calculations do not necessarily
represent the fair market value of individual options, and are not
intended to forecast possible future appreciation, if any, of the price of
our common stock on the date of exercise as compared to the exercise price
of the option.
19
<PAGE>
The following table shows for the fiscal year ended December 31, 1999,
certain information regarding options exercised by, and held at year end by,
the Named Executive Officers:
AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FY-END OPTION VALUES(1)
<TABLE>
<CAPTION>
Shares Number of Securities Value of Unexercised
Acquired Underlying Unexercised in-the-Money Options
on Exercise Value Options at FY-end (#) at FY-end(3)
Name (#) Realized(2) Exercisable/Unexercisable Exercisable/Unexercisable
---- ----------- ----------- ------------------------- -------------------------
<S> <C> <C> <C> <C>
Arthur D. Levinson,
Ph.D. ................... 762,502 $23,658,922 584,223 / 832,203 $58,780,681 / $71,569,455
Susan D. Desmond-
Hellmann, M.D., M.P.H. .. 152,000 $ 2,123,063 139,801 / 401,751 $13,096,311 / $34,550,598
Louis J. Lavigne, Jr. .... 509,064 $14,909,286 193,317 / 361,579 $18,981,227 / $31,095,766
Stephen G. Juelsgaard..... 167,000 $ 3,547,000 185,104 / 223,832 $18,891,410 / $19,249,586
Dennis J. Henner, Ph.D. .. 268,500 $ 9,581,713 149,712 / 292,704 $14,642,439 / $25,172,524
</TABLE>
- --------
(1) Genentech has awarded no SARs.
(2) Fair market value of Genentech's common stock on the date of exercise
minus the exercise price. Also, see additional information below.
(3) Fair market value of Genentech's common stock, $134.50, at the close of
business on December 31, 1999, the last business day of 1999, minus the
exercise price of the options.
On June 30, 1999, we redeemed all of our special common stock held by
stockholders, other than Roche, at $41.25 per share in cash and retired all of
the shares of special common stock including those held by Roche. On July 23,
1999, Roche completed the sale of 44,000,000 shares of our common stock at
$48.50 per share. Prior to the redemption, options to purchase special common
stock were outstanding under several of our stock option plans. In connection
with the redemption, certain of these options were canceled in exchange for
cash payments or the issuance of replacement options to purchase common stock
and certain of the options were converted or "rolled over" into options to
purchase common stock. The cash payments are included in the aggregate
exercises shown above. The stock options received in replacement of canceled,
unvested options are included in option grants in the last year, as shown on
the previous page. Two of the existing option plans were terminated and a new
option plan was implemented.
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<PAGE>
The following table sets forth, with respect to each of the Named Executive
Officers, (i) the amount of cash received for options canceled in connection
with the redemption of our special common stock and (ii) certain information
with respect to the number and value of options converted, in connection with
the redemption of our special common stock, into options to purchase a like
number of shares of common stock.
Treatment of Options in Connection with the Redemption
<TABLE>
<CAPTION>
Number of Percent of
Securities Total
Underlying Converted
Converted Options Options Number/Exercise
Cash-Out of Exercisable/ Held by Price Expiration Present
Name Options Nonexercisable(1) Employees(2) ($/Share)(3) Date(s)(4) Value(5)
---- ------------- ----------------- ------------- ----------------- ---------- ------------
(in millions) (in millions)
<S> <C> <C> <C> <C> <C> <C>
Arthur D. Levinson,
Ph.D. ................. $15.4 600,000/0 7.3% 225,000 $25.0625 2/6/06- $9.6
200,000 $27.1250 4/26/14
175,000 $34.1875
Susan D. Desmond-
Hellmann, M.D.,
M.P.H. ................ $ 2.1 75,000/0 0.9% 75,000 $34.1875 6/17/08 $1.4
Louis J. Lavigne, Jr. .. $10.3 225,000/0 2.7% 60,000 $25.0625 2/6/06- $3.7
90,000 $27.1250 4/26/14
75,000 $34.1875
Stephen G. Juelsgaard... $ 3.0 149,000/0 1.8% 34,000 $25.0625 2/6/06- $2.6
75,000 $27.1250 4/26/14
40,000 $34.1875
Dennis J. Henner,
Ph.D. ................. $ 4.5 202,500/0 2.5% 67,500 $25.0625 2/6/06- $3.2
75,000 $27.1250 4/26/14
60,000 $34.1875
</TABLE>
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(1) These options were granted pursuant to the 1994 Plan and 1996 Plan and are
nonstatutory options.
(2) Based on a total of approximately 8.0 million converted options held by
employees, including the Named Executive Officers.
(3) The exercise price per share of options granted represented the fair
market value of the underlying shares of special common stock as based on
the closing selling price per share of our special common stock on the
trading day prior to the date of grant.
(4) The options granted have a term of ten to twenty years, as applicable,
subject to earlier termination upon the occurrence of certain events
related to termination of employment.
(5) Present value was determined under the Black-Scholes option pricing model
based on the following assumptions: expected volatility of 45%
(representing the annual variance in the monthly change in the price of
selected top-tier biotechnology companies over the prior 10 year period;
used as a proxy for the expected monthly volatility of the Genentech
stock); a risk free rate of 6.01% determined by the remaining life of each
option. Each option is valued at its exercise price, which is assumed to
be equivalent to the market price at the date of grant. This valuation
model was not adjusted for the vesting restrictions or the risk of
forfeiture of the options. Under SFAS 123, forfeitures may be estimated or
assumed to be zero; in this model, the forfeiture rate was assumed to be
zero. Our use of this model in accordance with rules adopted by the
Securities and Exchange Commission does not constitute an endorsement of
the model nor an acknowledgment that such model can accurately determine
the value of options. The valuation calculations do not necessarily
represent the fair market value of individual options, and are not
intended to forecast possible future appreciation, if any, of the price of
our common stock on the date of exercise as compared to the exercise price
of the option.
21
<PAGE>
LOANS AND OTHER COMPENSATION
In 1994, Genentech lent $250,000 to Ms. Kimberly Popovits, Vice President,
Sales, for the purchase of a home in connection with her relocation to the San
Francisco Bay Area. The loan is imputed to bear interest at the rate of 8.20%.
$100,000 of the loan will be forgiven in five equal amounts on the anniversary
dates of the loan, provided Ms. Popovits is employed by Genentech on such
anniversary dates. The largest amount outstanding under the loan during 1999
was $184,089 and as of the date of this Proxy Statement no amount of the loan
remains outstanding. The imputed interest on the loan is compensatory to Ms.
Popovits and amounted to $14,089 in 1999.
In 1997, Genentech lent $150,000 to Ms. Judy Heyboer, Senior Vice President,
Human Resources, for the purchase of a home in connection with her relocation
to San Mateo County. The loan is imputed to bear interest at the rate of
6.74%. $75,000 of this loan is due and payable on the earlier of the fifth
anniversary of the date of the loan or the date of termination of Ms.
Heyboer's employment with Genentech. The remaining $75,000 will be forgiven in
five equal installments on the anniversary dates of the loan, provided Ms.
Heyboer is employed by Genentech on each of the forgiveness dates. The largest
amount outstanding under this loan during 1999 was $143,572 and $120,000 of
the principal balance of this loan is outstanding as of the date of this Proxy
Statement. The imputed interest on this loan is compensatory to Ms. Heyboer
and amounted to $8,573 in 1999.
In 1994, Genentech lent $60,000 to Mr. Sean Johnston, Vice President,
Intellectual Property, for the purchase of a home. The loan is imputed to bear
interest at the rate of 6.98%. The largest amount outstanding under this loan
during 1999 was $64,261, and as of the date of this Proxy Statement the loan
has been fully repaid. The imputed interest is compensatory to Mr. Johnston
and amounted to $4,261 in 1999.
In 1999, Genentech lent $250,000 to Dr. Stephen Dilly, Vice President,
Medical Affairs, for the purchase of a home in connection with his relocation
to the Bay Area. The loan is imputed to bear interest at the rate of 5.21%.
$58,333 is due and payable in each of the next two years and, assuming Dr.
Dilly's continued employment with Genentech, $75,000 of the loan will be
forgiven on April 12, 2004. On the same date, an additional payment of $58,333
is due. The largest amount outstanding under this loan during 1999 was
$259,854. The amount of this loan outstanding as of the date of this Proxy
Statement is $250,000. The imputed interest on this loan is compensatory to
Dr. Dilly and amounted to $9,854 in 1999.
In 1999, Genentech made interest free loans for a total of $450,000 to Ms.
Diane Parks, Vice President, Marketing, for the purchase of a home in
connection with her relocation to the Bay Area. In July 1999, Genentech lent
Ms. Parks $250,000. $150,000 of this loan is due and payable on the earlier of
the fifth anniversary of the date of the loan or the date of termination of
Ms. Parks' employment with Genentech. Over the next five years on the
anniversary date of the loan, $20,000 is forgiven each year, provided that,
Ms. Parks is employed by Genentech on the forgiveness date. In November 1999,
Genentech lent Ms. Parks $200,000, of which $175,000 was repaid in November
1999. The remaining $25,000 is due and payable on the earlier of the fifth
anniversary of the date of the loan or the date of termination of Ms. Parks'
employment with Genentech or the sale of her current residence. The largest
amount outstanding under for all loans during 1999 was $450,000. The amount of
the loans outstanding as of the date of this Proxy Statement is $275,000.
22
<PAGE>
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(1) The material in this report and under the caption "Performance Graph" are
not "soliciting material," are not deemed filed with the SEC and are not
to be incorporated by reference in any filing of the Company under the
Securities Act of 1933, as amended, or the Securities Exchange Act of
1934, as amended, whether made before or after the date of this Proxy
Statement and irrespective of any general incorporation language therein.
COMPENSATION COMMITTEE REPORT/1/
The Compensation Committee of the Board of Directors (the "Committee") is
currently composed of all the directors, except Dr. Levinson. The Committee is
responsible for setting and administering the policies that govern annual
executive salaries, bonuses (if any) and stock ownership programs. The
Committee annually evaluates the performance, and determines the compensation,
of the Chief Executive Officer ("CEO") and the other executive officers of
Genentech based upon a mix of the achievement of the corporate goals,
individual performance and comparisons with other pharmaceutical and
biotechnology companies. The CEO is not present during the discussion of his
compensation.
The policies of the Committee with respect to executive officers, including
the CEO, are to provide compensation sufficient to attract, motivate and
retain executives of outstanding ability and potential and to establish an
appropriate relationship between executive compensation and the creation of
shareholder value. To meet these goals, the Committee has adopted a mix among
the compensation elements of salary, bonus and stock options, with some bias
toward stock options to emphasize the link between executive incentives and
the creation of shareholder value as measured by the equity markets. In
general, the salaries and stock option awards of executive officers are not
determined by the Company's achievement of specific corporate performance
criteria. Instead, the Committee determines the salaries for executive
officers based upon a review of salary surveys of other pharmaceutical,
biotechnology and San Francisco Bay Area companies performed for the
Committee. To provide the Committee with more information for making
compensation comparisons, Genentech surveys a broader group of pharmaceutical
and biotechnology companies than those companies included in the Standard &
Poors Healthcare (Drug) Index shown on Genentech's Performance Graph. Based
upon such surveys, the executive officers' salaries are targeted at the
fiftieth (50th) percentile, and officers' salaries and bonuses, together with
all other benefits, are targeted at the seventy-fifth (75th) percentile, as
compared to other biotechnology companies, while stock options are set in the
mid to high range compared to other pharmaceutical companies.
In awarding stock options, the Committee considers individual performance,
overall contribution to Genentech, officer retention, the number of unvested
stock options and the total number of stock options to be awarded. In
determining where a given officer's total compensation, including the CEO's,
is set within the ranges and in light of the considerations described above,
the Committee subjectively evaluates such factors as the individual's
performance and the success of Genentech as measured by earnings per share,
product development progress, research prospects, and other critical success
factors.
Bonuses are provided to executive officers as part of Genentech's company-
wide bonus plan. Payment of bonuses is expressly linked to the attainment of
specified corporate goals that the Committee sets at each year's December
meeting for the next year. Among other things, these goals determine whether a
bonus will be paid to all eligible employees and the amount of funding
available for the bonus pool. For the bonus for services rendered in 1999, the
corporate performance goals, in order of importance, related to: (i) business
and financial performance, including but not limited to increasing earnings
per share, revenues and net income percentage and forming strategic alliances
by in-licensing products and establishing relationships with other companies;
(ii) accelerating and expanding product development by filing Investigational
New Drug Applications, initiating or completing specified clinical trials
investigating the use of new products, selecting new products for development
and filing New Drug Applications or Product License Applications for new
indications of marketed products; and (iii) enhancing employee development. In
setting these goals, the Committee is cognizant of the long development cycle
for human pharmaceuticals. The corporate performance goals for bonuses
selected by the Committee seek to balance the desire for immediate earnings
and the longer term goal of enhancing
23
<PAGE>
shareholder value by bringing to market many of the potential therapies in
Genentech's research and development pipeline. In February 2000, the Committee
reviewed the corporate performance goals for bonuses and determined that
approximately $19.7 million of the $24.3 million of corporate bonus targets
were achieved. The Committee allocated a bonus to the current CEO based on the
achievement of the requisite corporate goals, as discussed above, and based on
the Committee's view that the CEO's performance in achieving those goals had
been excellent. In determining the 1999 bonuses, the Company's Executive
Committee requested that Executive Committee officer bonuses, including the
CEO's bonus, should not exceed in any significant manner their 1998 bonuses
(paid in 1999), with the exception of an individual whose responsibilities had
substantially increased, and that the standard incorporation of the 75th
percentile comparison (which would have resulted in increased bonuses beyond
what the general population received) not be considered as a determining
factor. The Committee set a range of 50% to 100% of salary for bonuses for
members of the Company's Executive Committee other than the CEO (Drs. Desmond-
Hellmann and Henner, Ms. Judy Heyboer, and Messrs. Juelsgaard, Lavigne and
James Panek). Within the applicable range, the Committee set the bonus for
each Executive Committee member based on the Committee's subjective evaluation
of the individual's performance and the recommendation of the CEO.
The Committee uses the same procedures described above for the other
executive officers in setting the annual salary, bonus and stock option awards
for the CEO. The CEO's salary is determined based on comparisons with
pharmaceutical and biotechnology companies as described above. In awarding
stock options, the Committee considers the CEO's performance, overall
contribution to Genentech, retention, the number of unvested stock options
held and the total number of options to be awarded. The CEO's bonus is
dependent on Genentech achieving the performance goals outlined above and the
Committee's subjective evaluation of the CEO's performance. As described
above, in determining where the CEO's total compensation is set within the
ranges and in light of the considerations described above, the Committee
subjectively evaluates such factors as the individual's performance and the
success of Genentech as measured by the factors outlined above. Compared to
other companies surveyed by Genentech, the current CEO's salary, bonus and
stock options are competitive.
Section 162(m) of the Code limits the federal income tax deductibility of
compensation paid to Genentech's CEO and to each of the Named Executive
Officers. Under Section 162(m), Genentech generally may deduct compensation
paid to such an officer only to the extent that it does not exceed $1 million
during any calendar year or is "performance-based" as defined in Section
162(m). Genentech expects that the deductibility limit of Section 162(m)
currently will have an insignificant effect on Genentech. Current cash
compensation paid to each of Genentech's executives, with one exception, is
less than $1 million per year and is thus generally fully deductible to the
Company. In addition, Genentech expects to receive a federal income tax
deduction in connection with the exercise of stock options granted to the
Named Executive Officers.
From the members of the Compensation Committee of Genentech:
Herbert W. Boyer, Ph.D.
Franz B. Humer, Ph.D.
Jonathan K.C. Knowles, Ph.D.
Sir Mark Richmond, Ph.D.
Charles A. Sanders, M.D.
24
<PAGE>
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
During 1999, Genentech's Compensation Committee consisted of Drs. Boyer,
Humer, Knowles, Richmond and Sanders. Dr. Boyer, a founder of the Company, was
a vice president of Genentech from 1976 to 1991 and is currently a consultant
to the Company. Dr. Humer joined The Roche Group in 1995 as the Head of its
Pharmaceuticals Division and is currently Chief Executive Officer of The Roche
Group. He is also a member of the Board of Directors and Chairman of the
Executive Committee of The Roche Group. Pursuant to the terms of the
affiliation agreement, Dr. Humer is serving on Genentech's Compensation
Committee as a designee of Roche. See "Relationship with Roche" above and
"Certain Relationships and Related Transactions" below for a description of
Genentech's relationship with Roche.
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
In January 1980, Genentech and Hoffmann-La Roche entered into an agreement
regarding the development and commercialization of human leukocyte ("alpha")
and fibroblast ("beta") interferons (the "Interferon License Agreement").
Pursuant to this agreement, as amended from time to time, Genentech granted
Hoffmann-La Roche a sole and exclusive, worldwide license to use and sell
(and, under certain circumstances, manufacture) alpha and beta interferons
using organisms and knowhow developed by Genentech and under patent rights
belonging to Genentech, for a period of 20 years. Pursuant to this agreement,
Genentech is entitled to royalties on sales of interferons by Hoffmann-La
Roche for 10 years after commercial introduction, unless the period of
exclusivity is extended for an additional 5-year, royalty-bearing period.
These royalties totaled $11.2 million in 1999.
Herceptin Licensing Agreement
On July 6, 1998, we entered into an agreement with Hoffmann-La Roche to
provide Hoffmann-La Roche exclusive marketing rights outside of the United
States for Herceptin. Under the agreement, Hoffmann-La Roche paid $40.0
million to us and has agreed to pay cash milestones tied to future product
development activities, to contribute equally with us up to a maximum of $40.0
million on global development costs and to make royalty payments of 20% on
aggregate net product sales outside the United States up to $500 million in
each calendar year and 22.5% on such sales in excess of $500 million in each
calendar year.
Amended and Restated Licensing Agreement
Summary of Key Changes: Under an agreement dated October 25, 1995, we
granted to Hoffmann-La Roche an option for ten years for licenses to use and
sell some of our products in non-U.S. markets. In July 1999, we amended this
licensing agreement with Hoffmann-La Roche by extending until at least 2015
Hoffmann- La Roche's option to license to use and sell products in non-U.S.
markets. Other key changes to the license agreement are summarized as follows:
. Hoffmann-La Roche may choose to exercise its option at the end of a
Phase III trial, if it pays a $10 million fee to us to extend its option
on the product;
. if Hoffmann-La Roche exercises its option after the completion of a
Phase III trial, Hoffmann- La Roche will reimburse us for 75% of our
development costs incurred after the completion of the Phase II trial
through the completion of the Phase III trial, and 50% of our
development costs incurred before completion of the Phase II trial.
Subsequent development costs for other indications will be shared
75%/25% by Hoffmann-La Roche and Genentech;
. on each Genentech Product for which Hoffmann-La Roche exercises its
option after completion of the Phase III trials, we will receive a
royalty of 15% on all sales until the later in each country of the
expiration of our relevant patent or 25 years from the first commercial
introduction; however, $5 million of any option extension fee paid by
Hoffmann-La Roche shall be credited against royalties
25
<PAGE>
payable to us in the first calendar year of sales by Hoffmann-La Roche
in which aggregate sales of the product exceeds $100 million;
. Hoffmann-La Roche will have the right to manufacture our products itself
if it can demonstrate that it is able to manufacture products at a lower
price than our supply price, if we are not able to supply Hoffmann-La
Roche's commercial requirements or if we intend to have a third party
manufacture the product;
. Hoffmann-La Roche will have the right to terminate a license for a
product upon 30 days notice;
. if Hoffmann-La Roche terminates its license based on a good faith
determination, after consultation with appropriate regulatory
authorities in the relevant country, that the product cannot be approved
for sale in one or more major European countries because of safety
issues, Hoffmann-La Roche will be liable for all obligations incurred
primarily to support registration outside the United States of that
product for up to six months after the termination is given; and
. if Hoffmann-La Roche terminates its license for other than safety
reasons, Hoffmann-La Roche shall be liable for all of its obligations
regarding the product for up to twelve months after the notice of
termination.
Genentech and Roche have also entered into a Small Molecule Screening
Agreement for the screening of Roche's chemical library using certain mutually
agreed Genentech assays to find lead molecules for development into small
molecule therapeutics. Roche has the responsibility for supplying the chemical
library to be screened. Genentech has the responsibility for supplying the
assays and for undertaking the initial screening. If the screening results in
the identification of a molecule of interest to one of the parties, that party
shall advise the other party of its interest. The second party can then elect
to proceed with the interested party and jointly develop the molecule or it
can choose to let the interested party develop the molecule on its own. If a
molecule is jointly developed, the parties are to share equally the cost of
joint development and to agree to a plan proportioning research and
development responsibilities between them based on their capability. If a
product is jointly developed, both Genentech and Roche have the right to make,
use and sell that product and will negotiate an allocation of the major
marketing territories between them as well as appropriate royalties payable by
each to the other for sales of that product in that party's marketing
territory. As a general principle, the markets for each product are to be
allocated on an equal basis, but Genentech is to have at least 50% of the
marketing rights in North America and Roche is to have at least 50% of the
marketing rights in Europe, subject to certain exceptions. After allocation of
marketing rights, each party is to pay the other a royalty on sales in that
party's marketing territory with the royalty to be determined by negotiation.
As a general principle, the percentage royalty payable on sales by either
party to the other should have equivalent royalty rates. If a product is
unilaterally developed, the party unilaterally developing that product has the
sole right to make, use and sell that product throughout the world and will
pay the other party a royalty of 5% of sales.
See also "Relationship with Roche" starting on page 2.
Fidelity Management Trust Company ("FMTC"), a wholly-owned subsidiary of FMR
Corp. which at December 31, 1999 was the beneficial owner of 5.81% of the
Company's common stock, is the trustee of the trust fund for Genentech's Tax
Reduction Investment Plan (401(k) Plan). Amounts paid to FMTC for its services
as trustee totaled $12,229 in 1999.
26
<PAGE>
PERFORMANCE GRAPH
The following chart shows a comparison of five-year cumulative total
stockholder return as of December 31 among Genentech, the Standard & Poors
Healthcare (Drug) 500 Index, and the Standard & Poors 500 Index:(1)
TOTAL STOCKHOLDER RETURNS
PERFORMANCE GRAPH APPEARS HERE
<TABLE>
<CAPTION>
Healthcare (Drugs--
Major
Genentech Inc S&P 500 Index Pharmaceuticals)-500
------------- ------------- --------------------
<S> <C> <C> <C>
December 94............... 100.00 100.00 100.00
December 95............... 116.12 137.51 171.48
December 96............... 117.53 169.17 213.86
December 97............... 132.89 225.60 340.61
December 98............... 174.66 290.09 516.75
December 99............... 591.79 351.12 424.97
</TABLE>
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(1) The total return on investment (change in year end stock price plus
reinvested dividends) assumes $100 invested on December 31, 1994, in
Genentech, the Standard & Poors Healthcare (Drug) 500 Index (comprised of
Eli Lilly & Company, Merck and Company, Inc., Pfizer Inc., the Schering-
Plough Corporation and Pharmacia & Upjohn, Inc.), and the Standard & Poors
500 Index.
27
<PAGE>
PROPOSAL 4--RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS
The Board of Directors has selected Ernst & Young LLP as Genentech's
independent auditors for the year ending December 31, 2000, and has further
directed that management submit the selection of independent auditors for
ratification by the stockholders at the Annual Meeting. Ernst & Young LLP has
audited Genentech's financial statements since its inception in 1976.
Representatives of Ernst & Young LLP are expected to be present at the Annual
Meeting, will have an opportunity to make a statement if they desire to do so
and will be available to respond to appropriate questions.
Stockholder ratification of the selection of Ernst & Young LLP as
Genentech's independent auditors is not required by the Bylaws or otherwise.
The Board of Directors has elected to seek such ratification as a matter of
good corporate practice. Should the stockholders fail to ratify the selection
of Ernst & Young LLP as independent auditors, the Board of Directors will
consider whether to retain that firm for the year ending December 31, 2000.
The affirmative vote of the holders of a majority of the common stock
represented at the Annual Meeting is required for approval of this proposal.
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE IN FAVOR OF SUCH RATIFICATION.
28
<PAGE>
OTHER MATTERS
The Board of Directors knows of no other business to be presented at the
Annual Meeting, but if other matters do properly come before the Annual
Meeting, it is intended that the persons named on the Proxy Card will vote on
such matters in accordance with their best judgment.
Stockholder proposal for 2001 Annual Meeting. Notice of any stockholder
proposal that is intended to be presented by such stockholder at Genentech's
2001 Annual Meeting and included in the Proxy Statement relating to that
meeting must be received by the Secretary of the Company no later than
December 18, 2000 in order that it may be considered for possible inclusion in
the Proxy Statement and the form of Proxy Card relating to that meeting.
29
<PAGE>
[printed on recycled paper with soy based ink]
SKU #0724-PS-00
<PAGE>
Exhibit A/1/
Genentech, Inc.
1999 Stock Plan
Section 1. Purposes of the Plan. The purposes of this 1999 Stock Plan are:
. to attract and retain the best available personnel for positions of
substantial responsibility,
. to provide additional incentive to Employees, Directors and Consultants,
and
. to promote the success of the Company's business.
Section 2. Definitions.
(i) "Director" means a member of the Board.
(k) "Employee" means any person, including Officers and Directors employed
by the Company or Subsidiary of the Company. [An individual] A Service
Provider shall not cease to be an Employee in the case of (i) any leave
of absence approved by the Company or (ii) transfers between locations
of the Company or between the Company, any Subsidiary, or any
successor. For purposes of Incentive Stock Options, no such leave may
exceed ninety days, unless reemployment upon expiration of such leave
is guaranteed by statute or contract. If reemployment upon expiration
of a leave of absence approved by the Company is not so guaranteed,
then three (3) months following the 91st day of such leave any
Incentive Stock Option held by the Optionee shall cease to be treated
as an Incentive Stock Option and shall be treated for tax purposes as a
Nonstatutory Stock Option. [Neither service as a member of the
Company's Board of Directors nor payment of a director's fee by the
Company shall be sufficient to constitute "employment" by the Company.]
- --------
(1) New language in italics. Deleted language in brackets.
A-1
<PAGE>
PROXY
GENENTECH, INC.
PROXY SOLICITED BY THE BOARD OF DIRECTORS FOR THE ANNUAL MEETING OF
STOCKHOLDERS TO BE HELD ON MAY 15, 2000
The undersigned hereby appoints Stephen G. Juelsgaard and Arthur D.
Levinson and each of them (to act by unanimous decision if each of them shall
act), as attorneys and proxies of the undersigned, with full power of
substitution and resubstitution, to vote all of the shares of Common Stock of
Genentech, Inc. ("Genentech") that the undersigned may be entitled to vote at
the Annual Meeting of Stockholders of Genentech to be held at the Westin Hotel,
1 Old Bayshore Highway, Millbrae, California on Monday, May 15, 2000, commencing
at 10:00 a.m., local time, and at any and all continuations and adjournments
thereof, with all powers that the undersigned would possess if personally
present, upon and in respect of the following matters and in accordance with the
following instructions.
UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR ALL
NOMINEES FOR DIRECTOR LISTED IN PROPOSAL 1, FOR PROPOSALS 2, 3 AND 4 AS
MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT AND IN THE DISCRETION OF
THE PERSONS NAMED ABOVE AS PROXIES IN ANY OTHER MATTER WHICH MAY PROPERLY
COME BEFORE THE MEETING. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY
WILL BE VOTED IN ACCORDANCE THEREWITH.
YOU MAY REVOKE THIS PROXY AT ANY TIME PRIOR TO THE VOTE AT THE ANNUAL
MEETING.
<TABLE>
<CAPTION>
SEE REVERSE SIDE PLEASE COMPLETE, DATE AND SIGN THIS PROXY AND SEE REVERSE SIDE
RETURN IT IN THE ACCOMPANYING ENVELOPE.
<S> <C> <C>
VOTE BY TELEPHONE VOTE BY INTERNET
Its fast and convenient! It's fast and convenient!
Call Toll-Free on a Touch-Tone Phone
1-877-PRX-VOTE (Telephone voting is
available only in the United States and Canada)
Follow these four easy steps: Follow these four steps:
1. Read the accompanying Proxy Statement and 1. Read the accompanying Proxy Statement and
Proxy Card. Proxy Card.
2. Call the toll-free number 1-877-PRX-VOTE 2. Go to the Website
(1-877-779-8683) http://www.eproxyvote.com/dna
3. Enter your 14-digit Control Number located on your 3. Enter your 14-digit Control Number located
Proxy Card above your name. on your Proxy Card above your name.
4. Follow the recorded instructions. 4. Follow the instructions provided.
Your vote is important! Your vote is important!
Call 1-877-PRX-VOTE Go to http://www.eproxyvote.com.dna
24 hours a day -----------------------------
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You do not need to return your Proxy Card if you are voting by Telephone or Internet
</TABLE>
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Your telephone or Internet vote authorizes the named proxies to vote your
shares in the same manner as if you marked, signed and returned your proxy card
by mail. Please note that all votes cast via telephone or the Internet must be
cast prior to 3:00 p.m., eastern time, on Friday, May 12, 2000. If you wish to
change or revoke your vote you may re-vote via telephone or the Internet, or
return your properly completed proxy card; your latest vote received prior to
the applicable deadline will override each of your previous votes. If you wish
to change your address, please mark the box below and return your proxy card by
mail.
Please mark [X] votes as in this example.
THE BOARD OF DIRECTORS OF GENENTECH, INC. RECOMMENDS A VOTE FOR THE NOMINEES
FOR DIRECTOR LISTED BELOW AND A VOTE FOR PROPOSALS 2, 3 AND 4.
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1. To elect six directors to hold office until the 2001 2. To approve the amendment FOR AGAINST ABSTAIN
Annual Meeting of Stockholders to increase the number of
authorized shares of [ ] [ ] [ ]
Genentech common stock
Nominees: (01) Herbert W. Boyer, (02) Franz B. Humer, (03)
Jonathan K.C. Knowles, (04) Arthur D. Levinson, (05)
Charles A. Sanders and (06) Mark Richmond
FOR WITHHELD 3. To approve the amendment FOR AGAINST ABSTAIN
ALL [ ] [ ] FROM ALL to the Genentech
NOMINEES NOMINEES 1999 Stock Plan to allow [ ] [ ] [ ]
option grants to directors.
[ ] ______________________________________ 4. To ratify the selection of FOR AGAINST ABSTAIN
For all nominees except as noted above Ernst & Young LLP as
independent public accountants [ ] [ ] [ ]
of Genentech for the year
ending December 31, 2000.
5. By my signature below, I confer to the named proxies
discretionary authority on any other business that may
properly come before the meeting or any continuations and
adjournments thereof.
MARK HERE FOR ADDRESS CHANGE AND NOTE
AT LEFT [ ]
MARK HERE IF YOU PLAN TO ATTEND THE MEETING [ ]
Please sign exactly as name appears on this card. When signing
as attorney, executor, administrator, trustee or guardian,
please give full title. If more than one trustee, all should
sign. All joint owners must sign.
Signature _________________________ Date ______________ Signature _________________________ Date ______________
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