MERRILL LYNCH SERIES FUNDS INC
497, 2000-07-24
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                         MERRILL LYNCH SERIES FUND, INC.


                         SUPPLEMENT DATED JULY 24, 2000
           TO STATEMENT OF ADDITIONAL INFORMATION DATED APRIL 4, 2000


         THE  FOLLOWING  INFORMATION  SUPERSEDES  AND REPLACES  THE  INFORMATION
CONTAINED  IN  THE  STATEMENT  OF  ADDITIONAL   INFORMATION  UNDER  THE  CAPTION
"INVESTMENT RESTRICTIONS":


                             INVESTMENT RESTRICTIONS


     The  Fund  has  adopted  the  following   fundamental  and  non-fundamental
restrictions  and  policies  relating  to the  investment  of the  assets of the
Portfolios and their  activities.  The fundamental  policies set forth below may
not be  changed  without  the  approval  of the  holders  of a  majority  of the
outstanding voting shares of each Portfolio affected (which for this purpose and
under the Investment  Company Act of 1940, as amended (the  "Investment  Company
Act"),  means the  lesser of (i) 67% of the shares  represented  at a meeting at
which more than 50% of the  outstanding  shares of the  affected  Portfolio  are
represented  or (ii) more  than 50% of the  outstanding  shares of the  affected
Portfolio).  The non-fundamental policies set forth below may be changed by vote
of a majority of the Fund's Board of Directors at any time.

RESTRICTIONS APPLICABLE TO EACH PORTFOLIO (EXCEPT THE MONEY RESERVE PORTFOLIO)

     Each Portfolio (except the Money Reserve  Portfolio) has adopted investment
restrictions  numbered  1  through 9 as  fundamental  policies.  Each  Portfolio
(except the Money Reserve Portfolio) may not:

     (1)  Except  with  respect to the  Natural  Resources  and Global  Strategy
Portfolios, make any investment inconsistent with the Portfolio's classification
as a diversified company under the Investment Company Act.

     (2)  Invest  more than 25% of its  assets,  taken at market  value,  in the
securities of issuers in any particular  industry (excluding the U.S. Government
and its agencies and instrumentalities).

     (3) Make investments for the purpose of exercising control or management.

     (4)  Purchase or sell real  estate,  except that a Portfolio  may invest in
securities directly or indirectly secured by real estate or interests therein or
issued by companies which invest in real estate or interests therein.

     (5) Purchase or sell commodities or contracts on commodities, except to the
extent that a Portfolio  may do so in  accordance  with  applicable  law and the
Prospectus and Statement of Additional Information,  as they may be amended from
time to time,  and without  registering  as a commodity  pool operator under the
Commodity Exchange Act.

     (6) Make loans to other  persons,  except  that the  acquisition  of bonds,
debentures,  or other  corporate  debt  securities  and investment in government
obligations,   commercial  paper,  pass-through  instruments,   certificates  of
deposit,  bankers acceptances,  repurchase agreements or any similar instruments
shall not be  deemed  to be the  making of a loan,  and  except  further  that a
Portfolio  may lend its  portfolio  securities,  provided  that the  lending  of
portfolio  securities may be made only in accordance with applicable law and the
guidelines  set forth in the Fund's  Prospectus and this Statement of Additional
Information, as they may be amended from time to time.


<PAGE>

     (7) Borrow  money,  except that (i) a  Portfolio  may borrow from banks (as
defined  in the  Investment  Company  Act) in amounts up to 33-1/3% of its total
assets  (including  the amount  borrowed),  (ii) a Portfolio may borrow up to an
additional 5% of its assets for temporary purposes, (iii) a Portfolio may obtain
such  short-term  credit as may be necessary  for the clearance of purchases and
sales of portfolio  securities  and (iv) a Portfolio may purchase  securities on
margin to the extent permitted by applicable law. A Portfolio may not pledge its
assets  other than to secure such  borrowings  or, to the extent  permitted by a
Portfolio's investment policies as set forth in the Prospectus and the Statement
of  Additional  Information,  as they  may be  amended  from  time to  time,  in
connection  with  hedging  transactions,  short sales,  when-issued  and forward
commitment transactions and similar investment strategies.

     (8) Issue  senior  securities  to the extent such  issuance  would  violate
applicable law.

     (9)  Underwrite  securities of other issuers except insofar as the Fund may
be deemed an  underwriter  under the  Securities  Act of 1933,  as  amended,  in
selling portfolio securities.

     Each Portfolio (except the Money Reserve  Portfolio) has adopted investment
restrictions  numbered (a) through (g) as  non-fundamental  policies.  Under the
non-fundamental  investment  restrictions,  each  Portfolio  (except  the  Money
Reserve Portfolio) may not:

     (a) Purchase securities of other investment companies, except to the extent
such purchases are permitted by applicable law.

     (b) Make short sales of  securities  or maintain a short  position,  except
that the Multiple Strategy, Natural Resources and Global Strategy Portfolios may
maintain  short  positions  in  forward  currency  contracts,  options,  futures
contracts and options on futures contracts.

     (c) Purchase any  securities on margin,  except that a Portfolio may obtain
such  short-term  credit as may be necessary  for the clearance of purchases and
sales of portfolio securities,  and the Multiple Strategy, Natural Resources and
Global  Strategy  Portfolios  may  purchase  securities  on margin to the extent
permitted by applicable law.

     (d) Except for the Multiple Strategy, Natural Resources and Global Strategy
Portfolios,  write, purchase or sell puts, calls or combinations thereof, except
that the Capital Stock  Portfolio  and the Balanced  Portfolio may write covered
call options.

     (e) Except  with  respect  to the  Capital  Stock  Portfolio,  the  Natural
Resources  Portfolio,  the Global Strategy  Portfolio and the Multiple  Strategy
Portfolio, invest in securities of foreign issuers if at the time of acquisition
more  than  10% of its  total  assets,  and in the  case  of the  Capital  Stock
Portfolio  20% of its total  assets,  taken at  market  value at the time of the
investment, would be invested in such securities;  provided, however, that up to
25% of the total  assets of such  Portfolio  may be invested in  securities  (i)
issued, assumed or guaranteed by foreign governments,  or political subdivisions
or  instrumentalities  thereof,  (ii) assumed or guaranteed by domestic issuers,
including  Eurodollar  securities,  or (iii)  issued,  assumed or  guaranteed by
foreign issuers having a class of securities  listed for trading on the New York
Stock Exchange.  (As a matter of operating policy, however the Multiple Strategy
Portfolio will not invest in the securities of foreign issuers if at the time of
acquisition  more  than  25% of its  total  assets  would  be  invested  in such
securities.  In  addition,  the  Balanced  Portfolio,  as a matter of  operating
policy, does not intend to invest any portion of its assets in the securities of
foreign issuers.) Consistent with the general policy of the SEC, the nationality
or domicile of an issuer for  determination  of foreign issuer status may be (i)
the country under whose laws the issuer is organized,  (ii) the country in which
the issuer's  securities are principally traded, or (iii) a country in which the
issuer  derives a  significant  proportion  (at least  50%) of its  revenues  or
profits from goods produced or sold,  investments made, or services performed in
the country, or in which at least 50% of the assets of the issuer are situated.


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<PAGE>

     (f)  Participate  on a joint (or a joint and several)  basis in any trading
account in  securities  (but this does not include the  "bunching" of orders for
the sale or purchase of portfolio  securities with the other  Portfolios or with
individually  managed accounts advised or sponsored by the Investment Adviser or
any of its  affiliates to reduce  brokerage  commissions or otherwise to achieve
best overall execution).

     (g) Purchase or retain the  securities of any issuer,  if those  individual
officers and directors of the Fund,  the  Investment  Adviser or any  subsidiary
thereof each owning  beneficially  more than 1/2 of 1% of the securities of such
issuer, own in the aggregate more than 5% of the securities of such issuer.

RESTRICTIONS APPLICABLE TO THE MONEY RESERVE PORTFOLIO

     The Money Reserve Portfolio has adopted investment  restrictions numbered 1
through 9 as fundamental policies. The Money Reserve Portfolio may not:

     (1) Make any investment inconsistent with the Portfolio's classification as
a diversified company under the Investment Company Act.

     (2)  Invest  more than 25% of its  assets,  taken at market  value,  in the
securities of issuers in any particular industry (excluding securities issued by
the U.S.  Government  and its agencies and  instrumentalities;  and  instruments
issued by  domestic  banks;  and for  purposes of this  restriction,  issuers of
asset-backed and mortgaged-backed  securities will not be considered to be in an
industry).

     (3) Make investments for the purpose of exercising control or management.

     (4)  Underwrite  securities  of other issuers  except  insofar as the Money
Reserve Portfolio  technically may be deemed an underwriter under the Securities
Act of 1933, as amended, in selling portfolio securities.

     (5) Purchase or sell real estate,  except that, to the extent  permitted by
applicable law, the Money Reserve Portfolio may invest in securities directly or
indirectly  secured by real estate or  interests  therein or issued by companies
which invest in real estate or interests therein.

     (6) Borrow money,  except that (i) the Money  Reserve  Portfolio may borrow
from banks (as defined in the  Investment  Company Act) in amounts up to 33-1/3%
of its total  assets  (including  the amount  borrowed,  (ii) the Money  Reserve
Portfolio  may borrow up to an  additional  5% of its total assets for temporary
purposes, (iii) the Money Reserve Portfolio may obtain such short-term credit as
may be  necessary  for  the  clearance  of  purchases  and  sales  of  portfolio
securities,  and (iv) the Money  Reserve  Portfolio  may purchase  securities on
margin to the extent  permitted by applicable  law. These  borrowing  provisions
shall not apply to reverse repurchase  agreements as described in the Prospectus
and Statement of  Additional  Information.  The Money Reserve  Portfolio may not
pledge its assets other than to secure such borrowing or to the extent permitted
by the Money Reserve Portfolio's  investment policies as set forth in the Fund's
Prospectus and this Statement of Additional Information,  as they may be amended
from  time to time,  in  connection  with  hedging  transactions,  short  sales,
when-issued,  reverse repurchase and forward commitment transactions and similar
investment strategies.

     (7) Make loans to other  persons,  except  that the  acquisition  of bonds,
debentures or other debt  securities and  investment in government  obligations,
commercial paper,  pass-through  instruments,  certificates of deposit, bankers'
acceptances, repurchase agreements or any similar instrument shall not be deemed
to be the making of a loan, and except further that the Money Reserve  Portfolio
may lend its  portfolio  securities,  provided  that the  lending  of  portfolio
securities may be made only in accordance with applicable law and the guidelines
set forth in the Fund's Prospectus and this Statement of Additional Information,
as they may be amended from time to time.

     (8) Issue  senior  securities  to the extent such  issuance  would  violate
applicable law.

     (9) Purchase or sell commodities or contracts on commodities, except to the
extent that the Money Reserve  Portfolio may do so in accordance with applicable
law and the Fund's Prospectus and this


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<PAGE>

Statement of  Additional  Information,  as  they  may  be  amended  from time to
time,  and without  registering as a commodity pool operator under the Commodity
Exchange Act.

SPECIAL CONSIDERATIONS WITH RESPECT TO THE NATURAL RESOURCES PORTFOLIO

     In  determining  compliance  by the Natural  Resources  Portfolio  with its
policy on investing in the securities of issuers  primarily  engaged in the same
industry,  management will rely on the industrial  classifications  contained in
the Standard & Poor's Register of Corporations, Directors and Executives.


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