<TABLE> <S> <C>
<ARTICLE> 6
<CIK> 0000319108
<NAME> MERRILL LYNCH SERIES FUND, INC.
<SERIES>
<NUMBER> 091
<NAME> GLOBAL STRATEGY PORTFOLIO
<S> <C>
<PERIOD-TYPE> 6-MOS
<FISCAL-YEAR-END> DEC-31-2000
<PERIOD-START> JAN-01-2000
<PERIOD-END> JUN-30-2000
<INVESTMENTS-AT-COST> 199739712
<INVESTMENTS-AT-VALUE> 229701734
<RECEIVABLES> 4051045
<ASSETS-OTHER> 139505
<OTHER-ITEMS-ASSETS> 0
<TOTAL-ASSETS> 233892284
<PAYABLE-FOR-SECURITIES> 2577095
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 577576
<TOTAL-LIABILITIES> 3154671
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 189070287
<SHARES-COMMON-STOCK> 13668184
<SHARES-COMMON-PRIOR> 14074511
<ACCUMULATED-NII-CURRENT> 1920621
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 9719819
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 30026886
<NET-ASSETS> 230737613
<DIVIDEND-INCOME> 2393721
<INTEREST-INCOME> 1417453
<OTHER-INCOME> 8683
<EXPENSES-NET> (507990)
<NET-INVESTMENT-INCOME> 3311867
<REALIZED-GAINS-CURRENT> 9795216
<APPREC-INCREASE-CURRENT> (15095527)
<NET-CHANGE-FROM-OPS> (1988444)
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> (651509)
<DISTRIBUTIONS-OF-GAINS> (1518369)
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 480476
<NUMBER-OF-SHARES-REDEEMED> (1011940)
<SHARES-REINVESTED> 125137
<NET-CHANGE-IN-ASSETS> (10961112)
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> 1442972
<OVERDISTRIB-NII-PRIOR> (739737)
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 376119
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 507990
<AVERAGE-NET-ASSETS> 234341910
<PER-SHARE-NAV-BEGIN> 17.17
<PER-SHARE-NII> 0.24
<PER-SHARE-GAIN-APPREC> (0.37)
<PER-SHARE-DIVIDEND> (0.05)
<PER-SHARE-DISTRIBUTIONS> (0.11)
<RETURNS-OF-CAPITAL> 0
<PER-SHARE-NAV-END> 16.88
<EXPENSE-RATIO> 0.43
</TABLE>
