INTERNATIONAL REMOTE IMAGING SYSTEMS INC /DE/
DEF 14A, 1999-04-23
LABORATORY ANALYTICAL INSTRUMENTS
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<PAGE>   1
 
                            SCHEDULE 14A INFORMATION
 
                PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE
                        SECURITIES EXCHANGE ACT OF 1934
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                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
- --------------------------------------------------------------------------------
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<PAGE>   2
 
                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                                9162 Eton Avenue
                          Chatsworth, California 91311
 
                                 April 19, 1999
 
Dear IRIS Stockholder:
 
     1998 was the most challenging, and perhaps most difficult, year in this
decade.
 
     Revenues only matched those of a year earlier. It was the first time in
nine years that we did not achieve "double digit" revenue growth.
 
     Although operating income, that is earnings before interest and taxes, more
than doubled from a year earlier, IRIS recorded a net loss of $385,000, albeit
an improvement over the $503,000 loss a year earlier.
 
     While net income was adversely affected by a larger-than-normal increase in
operating expenses, I believe this increase was in our best interest, as we
aggressively addressed some of our more pressing operational and strategic
issues. Also note that more than $3.7 million was invested in product-oriented
research and development, the financial return on which is expected to become
more evident in the future.
 
     Without question, the most disappointing experience for both you and
management was the sharp decline in the value of our stockholdings. Clearly, the
fact that IRIS was operationally profitable and its cash flow was sufficient to
meet both interest obligations as well as reduce outstanding debt was not
sufficient for the forces that move the market.
 
     The mandate of management for the current year is quite clear and is being
firmly addressed, namely, to restore stockholder value and renew revenue and
earnings growth.
 
     In order to meet this mandate, management has already initiated new revenue
generating programs, rigorous cost saving and cash management measures and has
embarked on plans to ease the debt and interest burden as well as that of
amortization. These activities include strategic discussions with a number of
companies.
 
     PERFORMANCE. IRIS recently adopted reporting by operating segments which
allows us to track each of our business units and, in turn, provides you better
insight into their respective performance. Below, you see a summary of 1998
results.
 
     Urinalysis revenues increased five percent, small business devices revenues
were unchanged and those in our genetic analysis segment fell twelve percent,
the latter largely due to the non-recurrence of a record $1.25 million multi-
system sale in 1997. Clearly, our loss is confined to the genetic analysis
segment.
 
                   Segment and consolidated performance for calendar year 1998
                   -----------------------------------------------------------
<TABLE>
<CAPTION>
                                                                    Before tax
Segment                                       Net Revenues   net income (loss)
- -------                                       ------------   -----------------
<S>                                            <C>             <C>
Urinalysis                                     $17,000,874        $ 2,867,240
Genetic analysis                                 5,936,301         (2,748,950)*
Small devices                                    4,580,304          1,079,027
Unallocated corporate expenses                          --         (1,701,830)
                                               -----------        -----------
Consolidated                                   $27,517,479        $  (504,513)
</TABLE>
 
- ----------------------------
* Includes $2,040,507 of acquisition-related costs, interest and intangible
  amortization
 
     With this introduction of segment reporting, the complexity of various
financial and operational developments during 1998, and the many risks we face,
I encourage you to carefully review the accompanying 1998 Annual Report on Form
10-K. The rest of my letter highlights some of our progress and expectations.
 
     URINALYSIS BUSINESS SEGMENT. We continue to establish new customers in a
generally difficult US clinical laboratory instrument market.
 
     Our Model 900UDx urine pathology system is the most sophisticated
urinalysis product in the market today, setting new standards for
quality-of-result and cost-effectiveness. We have sold forty-three systems
worldwide. Trailing revenues from its supplies and service are substantial and
increasing. Our new 900UDx customers include the University of Illinois at
Chicago Medical Center, Hospital of the University of Pennsylvania, Thomas
Jefferson University Hospital, the Mayo Clinics, Hermann Hospital in Houston,
St. Barnabas Hospital in the Bronx, Our Lady of Fatima Hospital in Providence,
and Pomona Valley Medical Center in Pomona, CA. With the Houston installation,
all but one major hospital in the multi-hospital, world-renowned Texas Medical
Center rely on IRIS workstations to perform routine urinalysis.
<PAGE>   3
 
     In promising R&D news, we plan to adapt automatic recognition technology
developed under the Poly U/A Systems project with the collaboration of
California Institute of Technology scientists, Professor Yaser Abu-Mostafa and
two of his Ph.D. students, Drs. Joseph Sill and Xubo Song. Being further refined
for the next version of our Model 900UDx series and retrofittable into existing
systems, as well, it is expected to allow most microscopic results to be
released without need for review. At the same time, it retains images for review
when human interpretation is required. This improvement should make our
top-of-the-line of systems even more productive. We plan to submit a 510(k)
notification for its FDA clearance later this year.
 
     IRIS concluded its first full year of distribution of the IRIS/Sysmex
UF-100 urine cell analyzer. Five are now installed and operational. We expect
its sales to grow primarily among reference laboratories wanting to minimize
visual microscopy. Sysmex (formerly TOA Medical Electronics) recently asserted
it has the right to appoint additional distributors. We disagree. Unless Sysmex
can be dissuaded, this is likely to lead to more litigation.
 
     We expanded internationally. BioDPC, an established seller of Diagnostic
Products Corporation's (another Los Angeles company) immunoassay analyzers and
reagents, became our Turkish distributor. They have purchased twelve systems
from us to date. With 65 million people, Turkey is an excellent example of a
rapidly growing economy with a low-capacity healthcare infrastructure that must
expand quickly to meet demand. IRIS workstations are being used in some of the
most highly respected teaching hospitals in Turkey, including Marmara University
in Istanbul, Hacettept University in Ankara, Uludag University in Bursa, Firat
University in Elazig, and Osmangazi University in Eskisehir. BioDPC's success
exemplifies potential for future IRIS revenue growth in other countries.
 
     GENETICS BUSINESS SEGMENT. Late in 1997, we launched our PowerGene M-FISH
system developed in collaboration with Professor David Ward and his group at
Yale University. Since then, we have sold seventeen systems. This fully
integrated 24-color karyotyping system takes advantage of advances in multicolor
genetic analysis by Professor Ward and his coworkers, Drs. Speicher and Ballard.
 
     Investment in our first DNA probe product is near fruition. As part of our
Yale collaboration, PSI also obtained the recipe to make and formulate the
multi-DNA probe, multi-colored reagent cocktail used in M-FISH procedures and
arranged its commercial manufacture. We expect this will become PSI's first
consumable reagent and aid sales of M-FISH analyzers by providing a complete,
standardized system to perform this unique and powerful but complex procedure.
Initial distribution will be confined to international markets until certain
patent issues are resolved.
 
     We seek an even broader position in nucleic acid probe products by working
with others who have the necessary capabilities. A key objective is to grow a
trailing revenue stream as meaningful as we enjoy in our urinalysis business.
 
     Mayo Clinic, Royal Free Hospital in London (the largest teaching hospital
in the UK), and Royal Marsden Hospital in London (one of the oldest and most
respected cancer centers in the world) are now PowerGene users. We also supplied
additional workstations to existing networked installations at the Karolinska
Institute in Stockholm and Aristogen (the international division of Genzyme
Genetics) in Ingelheim. We now have installations in more than 500 laboratories
in over 40 countries.
 
     Of special note, we delivered a prototype automated rare event finder to
the NASA Johnson Space Center. The instrument will measure the effects of
radiation encountered by astronauts during spaceflight. Radiation causes
chromosomes to break, increasing the risk of cancer. We hope this system will
generate a new line of PowerGene products for early detection needs.
 
     We were awarded a Phase 1 Small Business Innovative Research (SBIR) grant
by the National Institutes of Health (NIH) to study new techniques to improve
the quality of microscope images of cells. Such improvements could impact both
our urinalysis and genetic imaging products. PSI scientists will work with Dr.
Lisa Shaffer of the Baylor College of Medicine and Dr. Jan Liang of the
University of Texas M.D. Anderson Cancer Center to prove feasibility of one or
more techniques which could lead to a much larger Phase 2 grant to commercialize
them.
 
     NIH also awarded PSI a $560,000 Phase 2 SBIR grant for a two-year study to
improve automated chromosome analysis on PowerGene karyotyping instruments,
using a mathematical method called "simulated annealing" to identify normal and
abnormal chromosomes more accurately. Success could mean a new generation of
PowerGene chromosome analyzers. This work is being done in collaboration with
Dr. Mark Pettenati of the Bowman Gray School of Medicine in Winston-Salem and
Dr. Janice Smith of the Laboratories for Genetic Services, Inc. in Houston.
 
     PSI also has a number of other NIH-supported projects underway. One is
aimed at diagnosing birth defects in unborn babies using only a sample of the
mother's blood, and another at detecting "cryptic" chromosome defects that are
too small to be seen by current methods. We think both hold significant
commercial potential.
 
     SMALL DEVICES BUSINESS SEGMENT. Bolstered by new products, increased
foreign sales and increased consumables sales from a growing instrument base,
StatSpin revenues recovered an almost $500,000 decline in OEM business from one
of its largest customers.
 
                                        2
<PAGE>   4
 
     We introduced three new or enhanced StatSpin products last year and expect
to introduce a new centrifuge, into the veterinary market this year.
 
     There was good market acceptance of several StatSpin products. The CytoFuge
2 system for preparing cells in body fluids for manual microscopic cytological
examination made inroads into a well-established competitive installed base,
nearly doubling its last year's numbers. Sales of the CenSlide system for manual
microscopic observation of urine sediment and sales of CritSpin devices for
physician's office determination of hematocrit were up nicely, too.
 
     Important modifications were made to the StatSpin Express and we expect to
introduce a new and improved 20,000-spin guaranteed StatSpin 2Xpress to help
realize the outstanding potential this product holds.
 
     PATENTS AND ROYALTIES. More than thirteen percent of our revenues were
spent on product-oriented research and development. This effort is the
foundation for an intellectual property portfolio now including forty-four U.S.
patents. Our proprietary technology was the basis for $465,000 of royalties
received during 1998.
 
     Two new patents were issued in 1998. One covers new urine chemistry control
compositions and the way they are used. U.S. Patent Number 5,795,783 describes
an improvement in the formulation of these compositions and their application in
measuring a variety of substances in urine. While used daily in the operation of
our urinalysis workstations, we expect more widespread opportunity for these new
controls outside of our traditional base.
 
     The second patent is for a novel display of particles used to enumerate
urine analytes and determine differential count of white blood cells (WBC). U.S.
Patent Number 5,822,447 describes a method and apparatus for combining image
data with graphical indicia so a specimen can be viewed all-at-once to see
immediately if it is normal or abnormal. This is a significant improvement over
previous display methods and time savings can be substantial.
 
     We received royalties of $180,000 from Sysmex from worldwide sales
(excluding North America) of the UF-100 urine cell analyzer based on a license
of pre-1989 know-how and technology granted to them during an earlier
collaboration between our companies. We also granted Sysmex a non-exclusive
license to use three of our patents for industrial applications in the Japanese
market, receiving additional royalties of $50,000.
 
     IRIS now holds more than twenty patents related to its Automated
Intelligent Microscopy technology. The validity of two patents included in the
industrial license to Sysmex was acknowledged in the settlement of last year's
patent litigation between IRIS and Intelligent Medical Imaging (IMI). IMI is
obligated to pay royalties on U.S. sales of its Micro 21 white blood cell
analyzer made through distributors. Such sales have been insignificant until
now, but this may change with IMI's recently announced Bayer and Beckman Coulter
distribution arrangements.
 
     On the small devices side of the business, Dade Behring also licensed one
of our small devices patents for a design used in their new cardiac assessment
analyzer, Stratus(R)CS. We received a $235,000 milestone payment in 1998 and
hope to receive additional royalties in the coming years.
 
     CORPORATE FINANCE. Cash flow management and adequate debt service are
crucial. During 1998 we maintained positive cash flow and reduced debt another
$1.0 million.
 
     Our new loan facility with Foothill Capital Corporation, now a division of
Wells Fargo, provides a line of credit of $7.0 million comprised of a term loan
of $3.6 million and a revolving line of credit of up to $4.0 million used for
additional working capital, as needed. At the end of 1998, we owed $2.9 million
on the term loan and were using $465,000 of the line of credit.
 
     POLY U/A SYSTEMS. IRIS fulfilled a contractual obligation to file a shelf
registration with the Securities and Exchange Commission to permit the public
resale, over the next several years, of up to 1,034,983 shares of IRIS Common
Stock, from the exercise of warrants acquired in connection with the Poly U/A
Systems program.
 
     IRIS and Poly U/A Systems, Inc. concluded a research and development
program to develop several new urinalysis products using IRIS technology. We
decided not to exercise our option to acquire Poly U/A Systems for $5.1 million,
and, instead, have made an offer to acquire it at a lesser price. Should we
acquire Poly U/A Systems, there would be operating accounting consequences as
explained in the Form 10-K.
 
     DITI ARBITRATION. A year after we acquired PSI from Digital Imaging
Technologies, Inc. (DITI) in 1996, we filed a demand for arbitration against
them alleging material breaches of representations, warranties and covenants in
the purchase agreement. DITI, in turn, filed a counterclaim alleging that we
misrepresented or omitted to disclose material facts. As part of the purchase
price, we issued DITI a warrant to purchase 875,000 shares of Common Stock at
$8.00 per share. They had previously requested a reduction in the exercise price
of the warrant but have since elected to seek unspecified monetary damages.
 
     The arbitration hearing is scheduled to begin before a Delaware tribunal in
May, and I plan to report on the status of the arbitration at the Annual
Meeting. While we are cautiously hopeful, we cannot assure its outcome.
 
     THE WHITE IRIS. The FDA cleared The White IRIS leukocyte differential
analyzer in 1996, but its commercial release was subsequently delayed by
introductions of the Model 900UDx urine pathology system and the UF-100 urine
 
                                        3
<PAGE>   5
 
cell analyzer. We elected not to launch it for the time being due to limited
resources and the potential impact of launch costs on near-term profitability.
Instead, we are exploring strategic alternatives.
 
     If we are unable to develop a viable strategic alternative and decide not
to proceed with product launch on our own, we would incur a charge against
future earnings of up to $1.2 million for the capitalized costs associated with
The White IRIS, principally unamortized software and inventory.
 
     MANAGEMENT CHANGES. IRIS marks 20 years as a business, today. At last
year's Annual Meeting, I announced my intention to step down from IRIS
leadership after almost all this time at the helm. IRIS should enter the new
millenium with the passing of the baton to a successor.
 
     To accomplish the succession process as well as continue our focus on the
many operational and strategic challenges we face, Dr. John A. O'Malley and Mr.
Roland Jang, long time IRIS advisers, joined me in the Office of the Chief
Executive. The three of us are sharing equally in key operational and strategic
decisions during the transition period.
 
     An IRIS founder, I have served as Chairman, President and CEO since 1980,
guiding IRIS through the challenging times of our formative years, and since
1990, spearheading our growth from a $4 million to the $28 million business we
now are. I expect to continue as Chairman and help solve our current problems so
our next CEO may concentrate his or her efforts on revenue growth and earnings.
 
     We appointed Dr. Richard Nadeau as a new member to our Board of Directors.
Dr. Nadeau brings us his rich and varied diagnostics industry business
experience and inimitable dynamic style and we welcome his participation. His
biographical sketch appears in the proxy statement following my letter and
meeting notice. Dr. Nadeau heads the search committee for my successor and, I am
pleased to report, has already brought forward two candidates for Board
consideration.
 
     PROXY STATEMENT AND ANNUAL MEETING. This year's Proxy Statement contains
two proposals. We endorse and ask your support for both of them. The first one
is for Dr. Kelley's and my re-election for renewed three-year terms as IRIS
directors. As you know, I have served in this capacity since 1979, when the
company was first founded and would like to continue this stewardship after
relinquishing my role as CEO. Dr. Kelley joined our Board following our 1996
acquisition of StatSpin, the company he founded.
 
     The other proposal is to ratify reappointment of PriceWaterhouseCoopers LLP
(formerly Coopers & Lybrand LLP) as our independent auditors.
 
     The Annual Meeting of Stockholders will be held at the Chatsworth Hotel,
located at 9777 Topanga Canyon Boulevard, Chatsworth, CA, about one mile north
and one mile west of our facilities. The meeting is Thursday, June 10, 1999,
beginning 4:00 p.m. local time. The Board of Directors and management of IRIS
invite and welcome your participation.
 
     Once again, please realize that this letter represents a sincere and honest
reflection on the past year at IRIS and some assessments of future prospects.
Many statements are forward-looking in nature and as a result are inherently
subject to the vagaries of future events which, as you know, are often
unpredictable. Again, I refer you to the more detailed Annual Report on Form
10-K for a fuller discussion of the opportunities, challenges and risks that
confront us in 1999.
 
                                   Sincerely,
                                   /s/ FRED H. DEINDOERFER
                                   Fred H. Deindoerfer
 
                                   Chairman of the Board and President
 
   THE ANNUAL MEETING IS ON JUNE 10, 1999. PLEASE RETURN YOUR PROXY IN TIME.
 
                                        4
<PAGE>   6
 
                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                                9162 Eton Avenue
                          Chatsworth, California 91311
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            To Be Held June 10, 1999
 
To the Stockholders of INTERNATIONAL REMOTE IMAGING SYSTEMS, INC:
 
     The Annual Meeting of Stockholders of International Remote Imaging Systems,
Inc. will be held at the Chatsworth Hotel at 9777 Topanga Canyon Boulevard,
Chatsworth, California, on June 10, 1999 at 4:00 p.m. local time for the
following purposes:
 
          1. To elect two Class 3 Directors to hold office until the year 2002
     annual meeting or until their successors are elected and qualified;
 
          2. To ratify the selection of PricewaterhouseCoopers LLP as
     independent public accountants for the fiscal year ending December 31,
     1999; and
 
          3. To transact such other business as may properly come before the
     meeting or any adjournments or postponements thereof.
 
     The Board of Directors has fixed the close of business on April 19, 1999,
as the record date for determination of stockholders entitled to notice of, and
to vote at, said meeting and any adjournments or postponements thereof.
 
     All stockholders are cordially invited to attend the meeting in person. In
any event, please mark, date, sign and return the enclosed proxy. The related
proxy statement and annual letter to stockholders are attached to this notice.
 
                                   By Order of the Board of Directors
                                   /s/ FRED H. DEINDOERFER
                                   Fred H. Deindoerfer
 
                                   Chairman of the Board and President
 
April 19, 1999
 
YOUR VOTE IS IMPORTANT. WHETHER OR NOT YOU EXPECT TO ATTEND THE ANNUAL MEETING
OF STOCKHOLDERS, PLEASE MARK, DATE, SIGN AND RETURN PROMPTLY THE ENCLOSED PROXY
IN THE STAMPED RETURN ENVELOPE PROVIDED. YOUR PROMPT RETURN OF THE PROXY WILL
HELP AVOID THE ADDITIONAL EXPENSE OF FURTHER SOLICITATION TO ASSURE A QUORUM AT
THE MEETING.
 
   THE ANNUAL MEETING IS ON JUNE 10, 1999. PLEASE RETURN YOUR PROXY IN TIME.
<PAGE>   7
 
                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                                9162 Eton Avenue
                          Chatsworth, California 91311
 
               PROXY STATEMENT FOR ANNUAL MEETING OF STOCKHOLDERS
                            To Be Held June 10, 1999
 
                     GENERAL INFORMATION AND VOTING RIGHTS
 
     This proxy statement (the Proxy Statement) and the enclosed proxy are
furnished in connection with the solicitation of proxies by the Board of
Directors of International Remote Imaging Systems, Inc., a Delaware corporation
(IRIS or the Company), for use at the Annual Meeting of Stockholders (the Annual
Meeting) to be held at the Chatsworth Hotel at 9777 Topanga Canyon Boulevard,
Chatsworth, California on Thursday, June 10, 1999, at 4:00 p.m. local time and
any adjournments or postponements thereof. Enclosed with this Proxy Statement is
a copy of the Company's Annual Report on Form 10-K (without exhibits) for the
fiscal year ended December 31, 1998. However, the Annual Report is not intended
be a part of this Proxy Statement or a solicitation of proxies. The Company
anticipates that the Proxy Statement and enclosed proxy will first be mailed or
given to its stockholders on or about April 21, 1999.
 
     A proxy may be revoked by filing with the Secretary a written notice of
revocation or a duly executed proxy bearing a later date, or by attending the
Annual Meeting and voting in person. Attendance in person at the Annual Meeting
does not itself revoke an otherwise valid proxy; however, any stockholder who
attends such meeting may orally revoke his proxy at the Annual Meeting and vote
in person. All properly executed proxies received prior to or at the Annual
Meeting, and not revoked, will be voted at the Annual Meeting with the
instructions indicated on such proxies. If no instructions are indicated, such
proxies will be voted FOR the election of the nominees as the Class 3 Directors
and FOR Proposal 2. In addition, the proxy holders will vote in their sole
discretion upon such other business as may properly come before the meeting and
any adjournments or postponements thereof.
 
     The cost of solicitation of proxies will be borne by the Company.
Directors, officers and regular employees of the Company may solicit proxies in
person, by telephone, by mail or by other means of communication, but such
persons will not be specially compensated for such services. The Company may
also reimburse brokers, banks, custodians, nominees and other fiduciaries for
their reasonable charges and expenses in connection with the distribution of
proxy materials.
 
     Only holders of record of the Company's common stock, $.01 par value per
share (Common Stock), at the close of business on April 19, 1999 will be
entitled to vote at the Annual Meeting on the proposals described in this Proxy
Statement. On that date, there were 6,437,875 shares of Common Stock
outstanding. Each holder of record is entitled to one vote on all matters to
come before the meeting for each share of Common Stock held. The Company also
had 3,000 shares of Series A Convertible Preferred Stock outstanding on April
19, 1999. The Series A Convertible Preferred Stock is not entitled to vote on
any matter except as required by law or the Certificate of Designation for the
Series A Convertible Preferred Stock. Accordingly, the holders of Series A
Convertible Preferred Stock will not be entitled to vote on any of the proposals
listed in this Proxy Statement, but they may have the right to vote on other
matters which may properly come before the meeting and any adjournments or
postponements thereof.
 
                        DIRECTORS AND EXECUTIVE OFFICERS
 
     The following table sets forth certain information regarding those
individuals currently serving as the directors and executive officers of the
Company:
 
<TABLE>
<CAPTION>
             Name                Age                        Position with the Company
- -------------------------------------------------------------------------------------------------------
<S>                              <C>       <C>
Fred H. Deindoerfer              69        Chairman of the Board, President and Member of the Office of
                                             the Chief Executive
John A. O'Malley                 65        Director and Member of the Office of the Chief Executive
Steven M. Besbeck                51        Director
Thomas F. Kelley                 66        Director
Richard G. Nadeau                63        Director
Roland Jang                      76        Member of the Office of the Chief Executive
Martin S. McDermut               48        Vice President, Finance and Administration, Secretary and
                                             Chief Financial Officer
Achille M. Bigliardi             56        Vice President and General Manager of Chatsworth Operations
Anthony G. Landells              45        Vice President and General Manager of PSI
</TABLE>
 
     The Board of Directors is divided into three classes with the directors in
each class holding office for staggered terms of three years each or until their
successors have been duly elected and qualified. Executive officers serve at the
<PAGE>   8
 
discretion of the Board of Directors. There are no familial relationships among
the directors and executive officers of the Company.
 
     Fred H. Deindoerfer, a founder of the Company, was elected a director in
1980 and became Chairman of the Board of Directors, President and Chief
Executive Officer later that year. In 1998, Dr. Deindoerfer was joined by Dr.
O'Malley and Mr. Jang as members of the Office of the Chief Executive upon its
expansion. See "Office of the Chief Executive." In addition, he served as Chief
Financial Officer from 1991 until August 1996. Prior to his employment with the
Company, Dr. Deindoerfer served as Executive Vice President of International
Diagnostic Technology, an in vitro diagnostic ("IVD") company which was acquired
by Boehringer Ingelheim, and earlier as an international group Vice President of
American Hospital Supply Corporation after serving as Vice President of its
McGaw Laboratories Division. He holds a B.S. from the University of Illinois, an
M.S. from Columbia University and a Ph.D. from the University of Pennsylvania,
all in Chemical Engineering.
 
     John A. O'Malley has served as a director since 1988 and became a member of
the Office of the Chief Executive upon its expansion in 1998. He is President of
Second Opinion, a consulting firm serving the healthcare diagnostic and
biotechnology industry and a director and Chief Operating Officer to Litmus
Concepts, Inc., a developer of point-of-care diagnostic tests for the women's
healthcare market. Dr. O'Malley is also a director of Cytometrics, Inc., a
privately-held development-stage company developing non-invasive, point-of-care,
diagnostic instrument systems. Prior to joining Second Opinion, he was worldwide
director of chemical manufacturing operations for the Milligen/Biosearch
Division which Millipore Corporation acquired from New Brunswick Scientific
where Dr. O'Malley had been its Vice President and General Manager. Previously,
he was President of Primary Diagnostic Systems and President of Smith Kline
Instruments, both IVD companies. Dr. O'Malley received his B.S. degree in
Chemistry from Rutgers, the State University of New Jersey, and his Ph.D. degree
in Physical Chemistry from the University of Pennsylvania. He also serves as
Chairman of the Board of Directors, Executive Vice President and General Manager
of Poly U/A Systems, Inc.
 
     Steven M. Besbeck has served as a director since 1990. He is President,
Chief Executive Officer and Chief Financial Officer of Creative Computer
Applications, Inc., a position he has held since 1983, as well as one of its
directors since 1980. Creative Computer Applications designs, develops, services
and markets laboratory, pharmacy and radiology information systems for clinical
laboratories. Prior to that, Mr. Besbeck was a director, President and Chief
Executive Officer of American Cytogenetics, Inc., a specialty clinical
laboratory, at various times over an eight-year period. Mr. Besbeck holds a B.S.
in Finance from California State University, Long Beach.
 
     Thomas F. Kelley was appointed a director in March 1996 and elected to his
first three-year term in June of that year. Until February 1, 1998, he was also
a Vice President of the Company and the General Manager of StatSpin. Dr. Kelley
is currently Chief Executive Officer of Imagepath Systems, Inc. an IVD imaging
systems integrator. From 1982 to the time of its acquisition by the Company, he
was President and Chairman of the Board of StatSpin. Prior to founding StatSpin,
Dr. Kelley was employed by Instrumentation Laboratory, Inc., in roles of
Director of Market Development and Director of Applied Research, among others.
Dr. Kelley received his B.A. and M.A. degrees in Biology from Boston University
in 1954 and 1955, respectively, and his Ph.D. in Biochemistry from Brown
University in 1959. He also serves as a director of BioNostics, Inc., an Acton,
Massachusetts-based original equipment and private-label manufacturer of
reagents, controls and calibrators.
 
     Richard G. Nadeau was appointed a director in January 1999 when the Board
was enlarged from four to five members. He is Chairman and Chief Executive
Officer of Cytometrics, Inc., a privately-held development-stage company
developing non-invasive, point-of-care, diagnostic instrument systems, which he
co-founded in 1992. Previously, Dr. Nadeau held senior positions with various
IVD equipment companies, including President and Chief Executive Officer of EM
Diagnostic Systems, Inc., Senior Vice President and Chief Technical Officer of
Technicon Instrument Corporation, President of the Diagnostics Division (North
America) of Technicon Instrument Corporation, President of Ortho Diagnostics,
Inc., a subsidiary of Johnson & Johnson, Inc., and Worldwide Marketing Manager
for the Automatic Clinical Analysis Division of E.I. DuPont de Nemours & Co. He
currently serves on the Board of Directors for the Health Industry Manufacturers
Association and has served as an advisor and consultant to the Food and Drug
Administration, Centers for Disease Control, the World Health Organization and
the National Bureau of Standards. Dr. Nadeau is a guest lecturer at the Wharton
School of Business, a former President of the National Committee for Clinical
Laboratory Standards and former Board Member of the European Committee for
Clinical Laboratory Standards. He earned his B.S. in Pre-Med and M.S. in
Biochemistry at the University of New Hampshire and his Ph.D. in Biochemistry at
West Virginia University.
 
     Roland Jang became a member of the Office of the Chief Executive upon its
expansion in 1998. Mr. Jang is a private investor and consultant who has worked
in top level positions for a number of healthcare diagnostic and high technology
electronics companies, including several successful startup companies he helped
found. Mr. Jang is Chairman of the Board of Directors of FlowScan Inc., a
company with a proprietary high sensitivity stethoscope in its
                                        2
<PAGE>   9
 
early stage of marketing and a member of the Board of Directors of Digital
Medical Systems, Inc., a company supplying a unique computer system to
consolidate and analyze input/output data in hospitals. FlowScan recently filed
for liquidation under Chapter 7 of the United States Bankruptcy Code. Mr. Jang
previously served as a member of the Company's Board of Directors for twelve
years following its inception and has frequently served as an advisor to Dr.
Deindoerfer on Company matters since then. He received his M.S. in Chemical
Engineering from the University of California at Berkeley.
 
     Martin S. McDermut joined the Company as Vice President of Finance and
Administration, Secretary and Chief Financial Officer in September 1996.
Immediately prior to this appointment, he was Chief Financial Officer of Edudata
Corporation which acquired Dental/Medical Diagnostic Systems in March of 1996.
Dental/Medical Diagnostic Systems develops, manufactures and markets intraoral
dental cameras. From June 1995 to April 1996, Mr. McDermut was Vice President
and Chief Financial Officer of All-Comm Media Corporation, and, prior to that,
he held the same roles at Pet Metro, Inc., an early stage retail chain. From
1975 to 1993, he was with the accounting and consulting firm of Coopers &
Lybrand L.L.P., becoming a partner in 1988. From 1990 to 1993, Mr. McDermut
practiced in the firm's Los Angeles Entrepreneurial Advisory Services Group and
was named its head in 1992. He is a Certified Public Accountant and holds an
M.B.A. in Finance and Accounting from the University of Chicago and a B.A. in
Economics from the University of Southern California.
 
     Achille M. Bigliardi joined the Company in 1991 as Western Regional Sales
Manager and was promoted to Director of Sales in 1993, to Vice President of
Sales and Service in 1994 and to General Manager of Chatsworth Operations in
1997. During his tenure as Vice President, sales and technical service
efficiency in dollar revenue has reached nearly double the industry average.
From 1982 until joining IRIS, Mr. Bigliardi gained valuable in vitro diagnostics
experience in several roles. He served as Executive Vice President and General
Manager of Sclavo, Inc., a European-based multinational medical diagnostics
company, and was President and co-founder of Aktis Corporation, a development-
stage IVD company, prior to its acquisition by Sclavo. He also served as Vice
President and Director of Marketing of SSI, Inc., and before then as Director of
Sales of International Diagnostic Technology, both medical diagnostics
companies. Mr. Bigliardi earned his B.S. and M.S. in Electrical Engineering from
the University of Michigan.
 
     Anthony G. Landells joined the Company in July 1996, upon the Company's
acquisition of PSI. He is currently a Vice President of the Company and the
General Manager of PSI. Previously, he was President of PSI. Mr. Landells also
is Managing Director and Chief Executive of PSI's United Kingdom subsidiary,
roles he held since joining PSI in 1992. A veteran in the field of digital
imaging technology, he was formerly Managing Director of Applied Imaging's
UK-based international operations, and earlier held senior management positions
with Image Recognition Systems and Joyce Loebl, both acquired by Applied
Imaging. Mr. Landells earned a B.S. in Electronic Engineering and an M.S. in
Computer Systems and Applications from the University of Sunderland in the
United Kingdom.
 
SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
     Under Section 16(a) of the Securities Exchange Act of 1934, the Company's
directors and officers and its significant stockholders (defined by statute as
stockholders beneficially owning more than 10% of the Common Stock) are required
to file with the Securities and Exchange Commission and the Company reports of
ownership, and changes in ownership, of Common Stock. Based solely on a review
of the reports received by it, the Company believes that, during the year ended
December 31, 1998, all of its officers, directors and significant stockholders
complied with all applicable filing requirements under Section 16(a) except the
following: Mr. Jang filed late his initial report on Form 3.
 
                         OFFICE OF THE CHIEF EXECUTIVE
 
     During 1998, the Company enlarged the Office of the Chief Executive to
three members. Dr. John A. O'Malley and Mr. Roland Jang, both long time advisers
to the Company, joined Dr. Fred H. Deindoerfer in the Office of the Chief
Executive on a part-time basis. Members of the office share equally in its key
operational and strategic decisions. The part-time members of the office are
compensated at the rate of $1,125 per day. Dr. O'Malley and Mr. Jang were paid
$29,988 and $31,194, respectively, and granted stock options for 50,000 shares
each, for their services as members of the Office of the Chief Executive during
1998. Mr. Jang also received $11,356 for consulting services rendered during
1998 prior his becoming a member of the Office of the Chief Executive.
 
     Dr. Deindoerfer, the Company's Chairman, President and Chief Executive
Officer for the past eighteen years, announced during 1998 his desire to retire
before the year 2000. The Company is currently making succession plans, and the
enlarged office structure is expected to assist with the succession process.
 
                                        3
<PAGE>   10
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information regarding the beneficial
ownership of Common Stock as of April 19, 1999 by (i) persons known to the
Company to beneficially own more than 5% of the outstanding Common Stock, (ii)
directors of the Company, (iii) the executive officers named below in the
"Summary Compensation Table" and (iv) all directors and executive officers of
the Company as a group. Unless otherwise indicated, the persons named below have
sole voting and investment power with respect to the number of shares set forth
opposite their names, subject to community property laws where applicable.
 
<TABLE>
<CAPTION>
                                                                 NUMBER OF
                                                                    SHARES
                                                              BENEFICIALLY     PERCENT OF
NAME OF BENEFICIAL OWNER(1)                                    OWNED(2)(4)    CLASS(3)(4)
- -----------------------------------------------------------------------------------------
<S>                                                           <C>             <C>
Fred H. Deindoerfer(5)......................................      498,981             7.6
John A. O'Malley............................................       42,418               *
Steven M. Besbeck...........................................       34,188               *
Thomas F. Kelley............................................       81,256             1.3
Richard G. Nadeau...........................................            0               *
Roland Jang.................................................       21,600               *
Martin S. McDermut..........................................       33,000               *
Achille M. Bigliardi........................................      130,900             2.0
Anthony G. Landells.........................................       89,453             1.4
Thermo Amex Convertible Growth Fund I, L.P.(6)..............    2,084,270            24.5
Digital Imaging Technologies, Inc.(7).......................      853,040            11.7
Sysmex Corporation(8).......................................      331,851             5.2
Directors and Executive Officers as a Group (9 persons).....      931,796            13.7
</TABLE>
 
- ---------------
 *  Less than 1%.
 
(1) Unless otherwise indicated, the mailing address of each person is c/o the
    Company, 9162 Eton Avenue, Chatsworth, California 91311.
(2) Includes warrants and options exercisable on or within 60 days of April 19,
    1999 held by directors and executive officers as follows: Dr. Deindoerfer
    (110,500 shares), Dr. O'Malley (21,900 shares), Mr. Besbeck (17,900 shares),
    Dr. Kelley (39,700 shares), Mr. Jang (16,600 shares), Mr. McDermut (33,000
    shares), Mr. Bigliardi (56,700 shares) and Mr. Landells (58,260 shares).
(3) Based on 6,437,875 shares of stock outstanding as of April 19, 1999.
(4) Beneficial ownership is determined in accordance with the rules of the
    Securities and Exchange Commission and generally includes voting or
    investment power with respect to the Common Stock. Shares of Common Stock
    issuable upon exercise of warrants and options exercisable on or within 60
    days of April 19, 1999 are deemed outstanding for purposes of computing the
    number and percentage of shares owned by the person holding such warrants or
    options but are not deemed outstanding for computing the percentage held by
    any other person.
(5) Includes 57,840 shares owned by family members or trusts to which Dr.
    Deindoerfer disclaims beneficial ownership shares.
(6) Consists of 3,000 shares of Series A Convertible Preferred Stock convertible
    into 2,000,000 shares of Common Stock at April 19, 1999 and a warrant to
    purchase 84,270 shares of Common Stock. The mailing address for Thermo Amex
    Convertible Growth Fund I, L.P. is Suite 1B, 4 Lafayette Court, Greenwich,
    Connecticut 06830. The fund shares voting and dispositive power over these
    securities with Thermo Amex Finance, L.P., Thermo Amex Management Company,
    Inc. and Thermo Electron Corporation. The information in the table and this
    footnote are based on the Schedule 13D filed jointly by all four entities on
    January 10, 1997.
(7) Consists entirely of a warrant to purchase 853,040 shares of Common Stock.
    The mailing address for Digital Imaging Technologies, Inc. is 2950 North
    West Loop, Suite 1050, Houston, Texas 77092. Digital Imaging Technologies,
    Inc. shares voting and dispositive power over these securities with Edward
    Randall, III. The information in the table and this footnote are based on
    the Schedule 13D filed jointly by Digital Imaging Technologies, Inc. and
    Edward Randall, III on August 8, 1996.
(8) Formerly known as TOA Medical Electronics Co., Ltd. The mailing address for
    Sysmex Corporation is 1-5-1 Wakinohama-Kaigandori, Chuo-ku, Kobe, Japan. The
    information in the table and this footnote are based on the Schedule 13D
    filed by TOA Medical Electronics Co., Ltd. on January 3, 1997 and subsequent
    correspondence with the Company.
 
                                        4
<PAGE>   11
 
                             EXECUTIVE COMPENSATION
 
SUMMARY COMPENSATION TABLE
 
     The following table sets forth the annual and long-term compensation of the
Company's senior member of the Office of the Chief Executive and up to four of
the other most highly compensated individuals serving as executive officers at
December 31, 1998, whose total annual salary and bonus exceeded $100,000 for the
fiscal year (the Named Officers).
 
<TABLE>
<CAPTION>
                                                                                                      LONG-TERM
                                                                                                   COMPENSATION
                                                                                                   ------------
                                                                             ANNUAL COMPENSATION      NUMBER OF
                                                 -----------------------------------------------         SHARES
                                                                                    OTHER ANNUAL     UNDERLYING        ALL OTHER
NAME AND PRINCIPAL POSITIONS                      YEAR(1)     SALARY     BONUS   COMPENSATION(2)        OPTIONS   COMPENSATION(3)
- ---------------------------------------------------------------------------------------------------------------------------------
<S>                                              <C>        <C>        <C>       <C>               <C>            <C>
Fred H. Deindoerfer                                  1998   $222,792   $     0       $21,808(4)          24,000       $   905(5)
  Chairman of the Board, President                   1997    233,861         0        28,215(4)          50,000           905(5)
  and Chief Executive Officer                        1996    208,681         0        36,464(4)               0         1,329(5)
Martin S. McDermut                                   1998    162,964         0             0             20,000         2,706(6)
  Vice President, Finance and                        1997    132,268    20,000             0             15,000         2,632(6)
  Administration, Secretary and                      1996     41,588     6,667             0             35,000           360(5)
  Chief Financial Officer
Achille M. Bigliardi                                 1998    195,998         0        30,231(7)          27,600         3,219(8)
  Vice President and General Manager                 1997    109,448    30,451        25,715(7)          30,000         2,384(8)
  of Chatsworth Operations                           1996    116,671    20,847        31,505(7)          13,400         2,253(8)
Anthony G. Landells                                  1998    129,401    44,045        27,352(4)               0        18,116(9)
  Vice President and General Manager                 1997    128,353    51,341        25,239(4)          10,000        16,390(9)
  of PSI                                             1996     49,910    39,289         7,813(4)          50,000         4,991(9)
</TABLE>
 
- ---------------
(1) Years represent calendar years. Information is provided only for those years
    in which the individual served as an executive officer.
(2) Other Annual Compensation consists of (a) the dollar value of the difference
    between the price paid for Common Stock purchased under the Company's
    Employee Stock Purchase Plan and the fair market value of such shares on the
    date of purchase ("ESPP benefits") and (b) automobile allowances. It does
    not include the value of perquisites because the aggregate value of
    perquisites did not exceed the lesser of $50,000 or 10% of any executive
    officer's salary and bonus for the applicable years.
(3) All Other Compensation consists of (a) premiums paid for term life insurance
    for the benefit of executive officers ("life insurance premiums") and (b)
    matching contributions to the Company's 401(k) plan for the benefit of
    executive officers ("401(k) matching contributions").
(4) Consists entirely of ESPP benefits.
(5) Consists entirely of payments for life insurance premiums.
(6) Consists of $1,076 and $1,046 for life insurance premiums and $1,630 and
    $1,586 in 401(k) matching contributions for 1998 and 1997, respectively.
(7) Consists of $27,781, $21,515 and $27,305 in ESPP benefits and $2,450, $4,200
    and $4,200 in automobile allowances for 1998, 1997 and 1996, respectively.
(8) Consists of $1,160, $980 and $891 for life insurance premiums and $2,059,
    $1,404 and $1,362 in 401(k) matching contributions for 1998, 1997 and 1996,
    respectively.
(9) Consists entirely of contributions for the benefit of the executive officer
    to a defined contribution pension plan maintained for the Company's United
    Kingdom employees.
 
OPTION GRANTS IN LAST FISCAL YEAR
 
     The following table sets forth certain information regarding stock option
grants during 1998 to the Named Officers. No stock appreciation rights were
granted during the year.
 
<TABLE>
<CAPTION>
                                                                                                       POTENTIAL REALIZABLE VALUE
                                                                                INDIVIDUAL GRANTS(1)            AT ASSUMED ANNUAL
- ----------------------------------------------------------------------------------------------------          PERCENTAGE RATES OF
                                                        % OF TOTAL                                       STOCK PRICE APPRECIATION
                                                   OPTIONS GRANTED                                             PER OPTION TERM(2)
                               NUMBER OF SHARES       TO EMPLOYEES                                     --------------------------
NAME                         UNDERLYING OPTIONS     IN FISCAL YEAR   EXERCISE PRICE   EXPIRATION DATE    0%         5%        10%
- ---------------------------------------------------------------------------------------------------------------------------------
<S>                          <C>                  <C>               <C>              <C>               <C>    <C>        <C>
Fred H. Deindoerfer                      24,000              8.4%       $1.31               11/06/03    0     $ 8,686    $19,194
Martin S. McDermut                       20,000              7.0%        2.06(3)             8/02/08    0      25,910     65,662
Achille M. Bigliardi                     25,000              8.8%        2.06(3)             8/02/08    0      32,388     82,078
                                          2,600              0.9%        1.31               11/06/03    0         941      2,079
</TABLE>
 
- ---------------
(1) Options vest annually in equal installments during the three years following
    the date of grant.
(2) Based on the assumption that the market price of the underlying shares of
    Common Stock appreciate in value from the date of grant to the date of
    expiration at the annualized rates indicated. These rates are hypothetical
    rates mandated by the Securities and Exchange Commission, and the Company
    does not make any representations regarding future appreciation in the
    market price of the Common Stock.
(3) These options were subsequently repriced. See "-- Stock Option Repricing
    Table."
 
                                        5
<PAGE>   12
 
AGGREGATED OPTION EXERCISES IN LAST YEAR AND YEAR-END OPTION VALUES
 
     The following table sets forth certain information regarding the exercise
of stock options during 1998 by the Named Officers and the final year-end value
of their unexercised options. None of the Named Officers exercised any stock
appreciation rights during 1998 or held any such rights at year end.
 
<TABLE>
<CAPTION>
                                                                      NUMBER OF SHARES UNDERLYING           VALUE OF UNEXERCISED
                                                                      UNEXERCISED OPTIONS/SARS AT   IN-THE-MONEY OPTIONS/SARS AT
                                             NUMBER OF                            FISCAL YEAR END            FISCAL YEAR END (1)
                                       SHARES ACQUIRED       VALUE    ---------------------------   ----------------------------
NAME                                       ON EXERCISE    REALIZED      EXERCISABLE/UNEXERCISABLE      EXERCISABLE/UNEXERCISABLE
- --------------------------------------------------------------------------------------------------------------------------------
<S>                                    <C>                <C>         <C>                            <C>
Fred H. Deindoerfer                                  0          $0                 106,500/57,500                          $0/$0
Martin S. McDermut                                   0           0                  28,050/41,950                           0/ 0
Achille M. Bigliardi                                 0           0                  52,144/52,256                           0/ 0
Anthony G. Landells                                  0           0                  36,300/23,700                           0/ 0
</TABLE>
 
- ---------------
(1) Based on the difference between the market price of a share of Common Stock
    on December 31, 1998 and the exercise price of the options.
 
STOCK OPTION REPRICING TABLE
 
     The following table sets forth certain information regarding the repricing
during the past ten calendar years of stock options previously granted to the
executive officers. See "Compensation Committee Report on Executive
Compensation -- Compensation Elements -- Stock Option Plans."
 
<TABLE>
<CAPTION>
                                                                                                                       LENGTH OF
                                        NUMBER OF SHARES     MARKET PRICE OF                                     ORIGINAL OPTION
                                              UNDERLYING        THE STOCK AT   EXERCISE PRICE AT                  TERM REMAINING
                                            OPTIONS/SARS             TIME OF             TIME OF                      AT DATE OF
                                             REPRICED OR        REPRICING OR        REPRICING OR   NEW EXERCISE     REPRICING OR
NAME                            DATE             AMENDED           AMENDMENT           AMENDMENT          PRICE      AMENDMENT(1)
- ---------------------------------------------------------------------------------------------------------------------------------
<S>                         <C>         <C>                 <C>                <C>                 <C>            <C>
Fred H. Deindoerfer         11/06/98              40,000              $1.31               $ 3.03      $1.31                  5.2
  Chairman of the Board,           "              50,000                  "                 3.03          "                  7.1
  President and Member of          "              50,000                  "                 3.38          "                  9.1
  the Office of the Chief   12/29/96              24,000               3.56                 4.00       3.03                  1.5
  Executive                        "              40,000                  "                 4.25          "                  7.0
                                   "              50,000                  "                 6.06          "                  9.0
                              1/7/89              10,000(2)            2.35(2)              9.55(2)    2.35(2)               1.8
                                   "              15,000(2)               "                10.30(2)       "                  2.1
                                   "               4,500(2)               "                 9.55(2)       "                  1.8
                                   "              10,500(2)               "                 9.55(2)       "                  1.8
                                   "              20,000(2)               "                 5.00(2)       "                  0.8
                                   "              20,000(2)               "                 9.55(2)       "                  1.8
                                   "               5,000(2)               "                 7.20(2)       "                  2.5
Martin S. McDermut           11/6/98              35,000               1.31                 3.03       1.31                  7.8
  Vice President, Finance          "              15,000                  "                 3.72          "                  8.2
  and Administration,
  Chief                            "              20,000                  "                 2.06          "                  9.8
  Financial Officer and     12/29/96              35,000               3.56                 6.53       3.03                  9.5
  Secretary
Achille M. Bigliardi         11/6/98              11,400               1.31                 3.03       1.31                  5.2
  Vice President and               "              10,000                  "                    "          "                  5.6
  General Manager of               "               2,000                  "                    "          "                  6.2
  Chatsworth Operations            "              10,000                  "                    "          "                  6.9
                                   "              13,400                  "                    "          "                  7.3
                                   "              15,000                  "                 3.94          "                  8.8
                                   "              15,000                  "                 3.38          "                  9.1
                                   "              25,000                  "                 2.06          "                  9.8
                            12/29/96               2,600               3.56                 4.00       3.03                  1.5
                                   "              10,000                  "                 4.04          "                  1.9
                                   "              11,400                  "                 4.25          "                  7.1
                                   "              10,000                  "                 3.72          "                  7.5
                                   "               2,000                  "                 4.25          "                  8.1
                                   "              10,000                  "                 6.22          "                  8.8
                                   "              13,400                  "                 5.63          "                  9.3
Anthony G. Landells          11/6/98              30,000               1.31                 3.03       1.31                  7.8
  Vice President and               "              20,000                  "                 3.03          "                  8.0
  General Manager of PSI           "              10,000                  "                 3.38          "                  9.1
                            12/29/96              30,000               3.56                 7.54       3.03                  9.5
                                   "              20,000                  "                 3.61          "                 10.0
</TABLE>
 
- ---------------
(1) Length of remaining option term in years.
 
(2) Adjusted to reflect a 1-for-5 reverse stock split in July 1993.
 
                                        6
<PAGE>   13
 
            COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION
 
     The Compensation Committee of the Board of Directors is primarily
responsible for determining the annual salaries and other compensation of
executive officers and administering the Company's stock option and stock
purchase plans. During 1998, the Compensation Committee consisted of Dr. John A.
O'Malley (Chairman) and Mr. Steven M. Besbeck.
 
COMPENSATION PHILOSOPHY
 
     The Compensation Committee believes the Company's future success depends in
large part on retaining and motivating its executive officers. As a result, the
Compensation Committee has adopted a general approach of compensating executives
with cash salaries commensurate with the experience and expertise of the
executive and competitive with median salaries paid to executives at comparable
companies. To reward executives for their contributions to the achievement of
Company-wide performance goals, incentive bonus awards are established at a
level designed to ensure that when such payouts are added to the executive's
base salary, the total compensation for above-average performance will exceed
the average compensation level at comparable companies. In addition, to align
its executives' compensation with the Company's business strategies, values and
management initiatives, both short and long term, executive officers are
provided with long-term performance incentives. It is the Company's policy to
encourage share ownership through the grant of stock option awards and stock
purchases under the Employee Stock Purchase Plan.
 
     In addition to the specific factors described below, the Compensation
Committee compared the total annual compensation levels (including stock
options) of the Company's executive officers to the compensation levels of
executive officers at other publicly-traded and private companies. Information
regarding compensation levels at other companies was derived from a variety of
sources, including proxy statements, a review of Executive Compensation for
CEO's by Towers Perrin, publications such as "The 1997 Report on Executive
Compensation" by Top Five Data Services, and compensation surveys reported in
business journals such as the "Medical Device & Diagnostic Industry Magazine."
Based on this information, the Compensation Committee believes that the
compensation levels of the Company's executive officers do not exceed the median
of their counterparts at comparable companies.
 
COMPENSATION ELEMENTS
 
     The Company's compensation package for executive officers consists of a
base salary, performance-based cash bonuses and stock options. The executive
officers are also eligible to participate in most of the Company's employee
benefit plans.
 
     Base Salaries. Base salaries are initially targeted at average levels of
comparable companies and then adjusted based on an assessment of individual
performance and contributions.
 
     Management Incentive Bonus Plan. The Management Incentive Bonus Plan (MIBP)
has been established to reward participants with cash bonuses for their
contributions to the achievement of Company-wide performance goals. All
executive officers of the Company and certain other key employees selected by
the Compensation Committee participate in the MIBP. MIBP payouts are established
at a level designed to ensure that when such payouts are added to a
participant's base salary, the total compensation for above-average performance
will exceed the average compensation level at comparable companies. Awards can
only be made to MIBP participants when their division of the Company, or the
Company as a whole, exceeds planned operating income goals.
 
     Stock Option Plans. The Company has established stock option plans to
provide employees with an opportunity to share with the stockholders in the
long-term performance of the Company. The Compensation Committee generally
grants stock options on a periodic basis to all eligible employees. Grants are
also made to certain employees upon commencement of employment and,
occasionally, following a significant change in job responsibility, scope or
title or a particularly noteworthy achievement. Stock options generally have a
three-year vesting schedule and expire ten years from the date of grant. The
exercise price is generally 100% of the market value of a share of Common Stock
at the time of the grant.
 
     The Compensation Committee has established general guidelines for
determining the size of periodic stock option grants based upon several factors,
including the salary and performance of the recipient and the market price of
the Common Stock at the time of grant. The size of the grants are targeted at
competitive levels.
 
     In response to the decline in the market price of the Common Stock during
1998, the Compensation Committee reduced the exercise price of certain
outstanding stock options with a higher price to $1.31 per share of Common
Stock. The new exercise price represented 100% of the market price of the Common
Stock at the time of the repricing. The Compensation Committee felt that the
decline in the market price of the Common Stock had significantly
 
                                        7
<PAGE>   14
 
diminished the incentive value of the Company's outstanding stock options and
that the repricing was necessary to retain adequate levels of incentive and
maintain competitive compensation levels. In order to emphasize the long-term
nature of the incentive, the Compensation Committee restricted the terms of the
repricing to prohibit the resale of shares acquired through the exercise of a
repriced stock option until January 1, 2000. In reaching its decision, the
Compensation Committee considered the fact that the executive officers would not
receive cash bonuses for 1998. See "Executive Compensation -- Stock Option
Repricing Table."
 
     Employee Stock Purchase Program. The Company maintains a stock purchase
plan that permits employees to purchase shares of Common Stock at discount of
50% from the then current market price. Employees may invest up to 15% of their
annual salary and bonus and must hold the shares for two years. If the employee
resigns from the Company during the holding period, the Company may repurchase
the shares at the employee's original purchase price. The Company's right to
repurchase the shares during the holding period automatically terminates under
certain circumstances such as a sale of the Company.
 
COMPENSATION OF CHIEF EXECUTIVE OFFICER
 
     The bonus for the Chief Executive Officer was based on (1) exceeding
present goals for operating income, (2) improvement of the market value of the
Company and (3) the achievement of extraordinary accomplishments (not directly
affecting operating earnings or stock value). The potential amount of the bonus
did not depend on (and was separate from) the MIBP for 1997 and 1998.
 
     Based on these factors, Dr. Deindoerfer did not receive a cash bonus for
1997 or 1998. However, based in large part on the Towers Perrin executive
compensation review, Dr. Deindoerfer's base salary was adjusted to an annual
rate of $210,000 effective June 12, 1998.
 
COMPENSATION OF OTHER EXECUTIVE OFFICERS
 
     The Compensation Committee established a formula early in the year for the
amount to be allocated to the MIBP based primarily on exceeding preset goals for
operating income. In determining the formula, the Compensation Committee
considered (1) the potential size of the bonus pool relative to the goal for
operating income in the Board-approved profit plan and (2) the challenge
presented by the profit plan in the current business environment. The
Compensation Committee considered three factors in determining individual cash
bonus awards for 1998: (a) the individual's salary multiplied by his or her
level of bonus participation (100% for executive officers), (b) the individual's
estimated contribution to the improvement of operating income and (c) the
individual's achievement of any other predefined performance goals assigned to
the individual. The Compensation Committee relied primarily upon the evaluations
and recommendations of the Unit Heads and the Chief Executive Officer.
 
     Based on these factors, none of the executive officers were awarded cash
bonuses for 1998 under the MIBP because the Company did not achieve its
pre-defined goals. However, one executive officer received a minimum guaranteed
bonus pursuant to an agreement made at the time of his hiring.
 
     Although the Compensation Committee did not award merit increases in base
salaries to corporate officers in 1998, Mr. Bigliardi's base salary was adjusted
to an annual rate of $170,000 based on the Towers Perrin executive compensation
review.
 
                                   COMPENSATION COMMITTEE
 
                                   Dr. John A. O'Malley (Chairman)
                                   Mr. Steven M. Besbeck
 
                           COMPENSATION OF DIRECTORS
 
     Non-employee directors receive a $13,500 per year retainer for normal,
routine services as a Board member. With the prior approval of the President,
additional consulting time is compensated at the rate of $1,125 per day. During
1998, Dr. O'Malley and Mr. Besbeck were paid $15,750 and $13,500, respectively,
for their services as directors. The non-employee directors were also awarded
stock options for 8,000 shares of Common Stock in 1998. Dr. Kelley is employed
by the Company on a part-time basis and was paid $45,920 for all his services to
the Company during 1998. Dr. Kelley did not receive any stock option awards
during 1998.
 
                                        8
<PAGE>   15
 
               COMMITTEES AND MEETINGS OF THE BOARD OF DIRECTORS
 
     The Board of Directors held a total of eight meetings during 1998. The
Board of Directors has two standing committees: an Audit Committee and a
Compensation Committee. There is no nominating committee or any other committee
performing those functions.
 
     The Audit Committee, which currently consists of Mr. Besbeck and Dr.
O'Malley, held one meeting during 1998. The Audit Committee reviews the scope
and results of the year-end audit with management and the independent
accountants and recommends to the Board of Directors selection of independent
accountants for the coming year.
 
     The Compensation Committee, which currently consists of Dr. O'Malley and
Mr. Besbeck, held seven meetings during 1998. The Compensation Committee is
primarily responsible for determining the annual salaries and other compensation
of executive officers and administering the Company's stock option and stock
purchase plans.
 
     No director attended fewer than 75% of the meetings of the Board of
Directors and the committees upon which such director served during 1998.
 
          COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     Dr. O'Malley is a member of both the Office of the Chief Executive and the
Compensation Committee. See "Office of the Chief Executive." He is also a
stockholder, director and officer of Poly UA Systems, Inc., a Company-sponsored
research and development entity. See "Certain Relationships and Related
Transactions -- Joint Development Project with Poly UA Systems." Dr. Nadeau is
Chairman and Chief Executive Officer of Cytometrics, Inc., a privately-held
development-stage company, and Dr. O'Malley is a director of Cytometrics and
serves on its Compensation and Audit Committees. See "Directors and Executive
Officers."
 
                  FIVE-YEAR STOCK PRICE PERFORMANCE COMPARISON
 
     The following graph and table compare the cumulative total return on the
Company's Common Stock with the cumulative total return (including reinvested
dividends) of the Standard & Poor's 500 Index (S&P 500), the Russell 2000 Index
(Russell 2000) and the Dow Jones Advanced Medical Devices Index for United
States Owned Companies (DJAMD) for the five years ending December 31, 1998,
assuming that the relative value of the Common Stock and each index was $100 on
December 31, 1993. Amounts below have been rounded to the nearest dollar.
 

                              [PERFORMANCE GRAPH]
 
<TABLE>
<CAPTION>
IRIS AND SELECTED INDICES                                            CALENDAR YEAR ENDING DECEMBER 31,
- -------------------------------------------------------------------------------------------------------
                                       1993        1994        1995        1996        1997        1998
                                       ----------------------------------------------------------------
<S>                                    <C>         <C>         <C>         <C>         <C>         <C>
IRIS                                   100         140         210         105          90          22
S&P 500                                100          98         132         159         208         264
Russell 2000                           100          97         122         140         169         163
S&P Healthcare                         100         116         194         220         272         389
</TABLE>
 
                                        9
<PAGE>   16
 
                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
JOINT DEVELOPMENT PROJECT WITH POLY U/A SYSTEMS
 
     The Company and Poly U/A Systems, Inc. ("Poly"), a Company-sponsored
research and development entity, have an agreement to develop several new
products to enhance automated urinalysis using the Company's technology. Poly
funded most of the cost of the project with the net proceeds from a 1995 private
placement of units, each unit consisting of shares of Poly common stock and
warrants to purchase common stock of the Company. The Company contributed
$500,000 toward the cost of the project and has no further funding commitments.
Poly has also satisfied its funding commitment, and no further development work
is planned at this time. The Company decided not to exercise its option to
acquire Poly but entered into ongoing discussions to acquire Poly at a price
below the option price. See "Business -- Research and Development" and
"Management's Discussion and Analysis of Financial Condition and Results of
Operations -- Liquidity" in the Company's 1998 Annual Report on Form 10-K.
 
     Dr. O'Malley is a director and the Executive Vice President and General
Manager of Poly and received approximately $22,200 from Poly for services
rendered in 1998. Some of the Company's directors and officers own shares of the
common stock of Poly as follows: Dr. O'Malley (2,000 shares), Dr. Deindoerfer
(2,000 shares), Dr. Kasdan (2,000 shares), and Mr. Bigliardi (2,000 shares).
Each of these individuals owns less than 1% of the total number of outstanding
shares of Poly, and collectively they beneficially own 3% of the total number of
outstanding shares of Poly.
 
AGREEMENTS WITH SYSMEX CORPORATION
 
     Sysmex Corporation, formerly TOA Medical Electronics Co., Ltd. ("Sysmex"),
a large stockholder, has a perpetual, royalty-bearing license from the Company
to market urine sediment analyzers using technology developed by the Company
before 1989. In the fourth quarter of 1997, the Company began marketing the new
IRIS/Sysmex UF-100 urine cell analyzer in the United States. The UF-100,
developed in Japan by Sysmex, utilizes flow cytometric laser scanning principles
to screen large volumes of urine specimens for the presence of abnormal sediment
compositions. The Company is the exclusive distributor for the UF-100 in North
America and receives royalty payments from Sysmex on sales of the UF-100 outside
of North America. However, Sysmex is now asserting that it has the right to
appoint additional distributors for the UF-100 in North America. The Company
disputes that Sysmex has this right. See "Business -- Products -- Other Systems"
in the Company's 1998 Annual Report on Form 10-K.
 
INTEREST PAYMENTS TO DIGITAL IMAGING TECHNOLOGIES
 
     In July 1996, the Company acquired PSI from Digital Imaging Technologies,
Inc. ("DITI"). The Company paid a portion of the purchase price by issuing to
DITI a $7.0 million Senior Subordinated Note. The note bears interest at the
rate of 8.5%, and the Company paid $595,000 of interest to DITI during 1998.
Principal is not due until maturity on July 31, 2001. The Company has filed an
arbitration claim against DITI alleging material breaches of the
representations, warranties and covenants in the purchase agreement governing
the PSI acquisition. See "Litigation" in the Company's 1998 Annual Report on
Form 10-K.
 
                                       10
<PAGE>   17
 
                                   PROPOSAL 1
 
                       ELECTION OF THE CLASS 3 DIRECTORS
 
     The Board of Directors consists of five directors divided into three
classes -- Class 1 (Mr. Besbeck and Mr. Nadeau), Class 2 (Dr. O'Malley) and
Class 3 (Dr. Deindoerfer and Dr. Kelley) -- with the directors in each class
holding office for staggered terms of three years each or until their successors
have been duly elected and qualified. At last year's annual meeting, the
stockholders re-elected Dr. O'Malley as the Class 2 director to hold office
until 2001.
 
     At the Annual Meeting this year or any adjournments or postponements
thereof, two Class 3 Directors will be elected to serve until their successors
are duly elected and qualified. The nominees for election as the Class 3
Directors are Dr. Fred H. Deindoerfer and Dr. Thomas F. Kelley. The Stockholders
elected Dr. Deindoerfer and Dr. Kelley as Class 3 Directors at the 1996 annual
meeting, and they are presently serving the Company in that capacity. The Class
3 Directors will serve until the year 2002 annual meeting or until their
successors are elected and qualified.
 
     The accompanying proxy grants to the holder the power to vote the proxy for
substitute nominees in the event that Dr. Deindoerfer or Dr. Kelley becomes
unavailable to serve as a Class 3 Director. Management presently has no
knowledge that either Dr. Deindoerfer or Dr. Kelley will refuse or be unable to
serve as a Class 3 Director for the prescribed term.
 
           THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE NOMINEES.
 
     Directors are elected by a "plurality" of the shares voted. "Plurality"
means that the nominees with the largest number of votes are elected, up to the
maximum number of directors to be chosen. Stockholders can either vote "for" the
nominees or withhold authority to vote for any one or all of the nominees.
However, shares that are withheld will have no effect on the outcome of the
election. Shares held by brokers or other nominees for a beneficial owner and
not voted (broker non-votes) also will not have any effect on the outcome of the
election of directors.
 
                                   PROPOSAL 2
 
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS
 
     The Board of Directors, upon a recommendation of its Audit Committee, has
selected the accounting firm of PricewaterhouseCoopers LLP as independent
auditors of the Company for the fiscal year ending December 31, 1999, subject to
ratification of the stockholders at the meeting. PricewaterhouseCoopers LLP has
no financial interest of any kind in the Company except the professional
relationship between auditor and client. A representative of
PricewaterhouseCoopers LLP is expected to attend the meeting, will be afforded
an opportunity to make a statement if he or she desires to do so, and will be
available to respond to appropriate questions by stockholders.
 
  THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR RATIFICATION OF THE SELECTION.
 
     Proposal 2 requires the affirmative vote of a majority of the votes cast on
the proposal. Stockholders may vote "for" or "against" the proposal, or they may
abstain from voting on the proposal. Abstentions (as well as broker non-votes)
will not have any effect on the outcome of the proposal.
 
                                       11
<PAGE>   18
 
                                OTHER PROPOSALS
 
     The Company is not aware of any other business to be presented to the
meeting and does not intend to bring any other matters before the meeting.
However, if any other matters properly come before the meeting, the persons
named in the accompanying proxy are empowered, in the absence of contrary
instructions, to vote according to their best judgment.
 
               STOCKHOLDER PROPOSALS FOR THE NEXT ANNUAL MEETING
 
     If a stockholder wishes to present a proposal at the next annual meeting of
stockholders, such a proposal must be received by the Company at its principal
executive offices prior December 23, 1999.
 
                                 ANNUAL REPORT
 
     In lieu of an Annual Report to Stockholders, the Company is delivering with
this Proxy Statement a copy of its Annual Report on Form 10-K (without exhibits)
for the fiscal year ended December 31, 1998. However, it is not intended that
the Annual Report on Form 10-K be a part of this Proxy Statement or a
solicitation of proxies.
 
       NOTE REGARDING INCORPORATION BY REFERENCE TO THIS PROXY STATEMENT
 
     The Company routinely files with the Securities and Exchange Commission
various registration statements and reports which may incorporate by reference
part or all of this Proxy Statement. Those references are not intended to
incorporate any of the information in this Proxy Statement under the headings
"Compensation Committee Report on Executive Compensation" or "Five Year Stock
Price Performance Comparison" unless those headings are specifically referenced
by name in the registration statement or report.
 
                                   By Order of the Board of Directors
                                   /s/ FRED H. DEINDOERFER
                                   Fred H. Deindoerfer
 
                                   Chairman of the Board and President
Chatsworth, California
April 19, 1999
 
PLEASE PROMPTLY VOTE, DATE, SIGN AND RETURN THE ENCLOSED PROXY, WHETHER OR NOT
YOU EXPECT TO ATTEND THE MEETING. A RETURN ENVELOPE IS ENCLOSED FOR YOUR
CONVENIENCE. NO POSTAGE IS REQUIRED IF MAILED WITHIN THE UNITED STATES. PROMPT
RESPONSE IS HELPFUL AND YOUR COOPERATION WILL BE APPRECIATED. AT ANY TIME BEFORE
A VOTE YOU MAY REVOKE YOUR PROXY BY (1) A LATER PROXY OR A WRITTEN NOTICE OF
REVOCATION DELIVERED TO THE INSPECTOR OF ELECTIONS OR (2) ADVISING THE INSPECTOR
OF ELECTIONS AT THE MEETING THAT YOU ELECT TO VOTE IN PERSON. ATTENDANCE AT THE
MEETING WILL NOT IN AND OF ITSELF REVOKE A PROXY.
 
   THE ANNUAL MEETING IS ON JUNE 10, 1999. PLEASE RETURN YOUR PROXY IN TIME.
 
                                       12
<PAGE>   19
 
                                   IRIS LOGO
 
                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                                9162 Eton Avenue
                              Chatsworth, CA 91311
                                 (818) 709-1244
<PAGE>   20
 
                                     PROXY
 
                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                                9162 ETON AVENUE
                          CHATSWORTH, CALIFORNIA 91311
 
                         ANNUAL MEETING OF STOCKHOLDERS
                                 JUNE 10, 1999
 
    The undersigned, revoking previous proxies, hereby appoint(s) Fred H.
Deindoerfer and Martin S. McDermut, or any of them, attorneys, with full power
of substitution, to vote all shares of common stock of International Remote
Imaging Systems, Inc. (the "Company") which the undersigned is (are) entitled to
vote at the Annual Meeting of Stockholders of the Company to be held at the
Chatsworth Hotel, 9777 Topanga Canyon Boulevard, Chatsworth, California, on
Thursday, June 10, 1999, at 4:00 p.m. and at any adjournments thereof. This
proxy shall be voted on the proposals described in the Proxy Statement as
specified below. Receipt of the Notice of Annual Meeting of Stockholders and the
accompanying Proxy Statement is hereby acknowledged.
 
    1. To elect two Class 3 Directors.
 
       [ ] FOR Fred H. Deindoerfer and   [ ] WITHHOLD AUTHORITY to vote for any
           Thomas F. Kelley (except as       of the nominees.
           in the space provided below):     withheld
 
INSTRUCTIONS: To withhold authority to vote for either of the nominees, write
              the name of the nominee on the following line:
 
            --------------------------------------------------------------------
 
    2. To ratify the selection of PricewaterhouseCoopers LLP as independent
auditors of the Company for 1999:
 
                     [ ] FOR          [ ] AGAINST          [ ] ABSTAIN
 
      The Board of Directors Recommends a Vote FOR each of the Proposals.
<PAGE>   21
 
               THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS
 
    This proxy will be voted as specified herein. If no specification is made,
it will be voted FOR all of the proposals. As to any other matters which may
properly come before the meeting or any adjournments thereof, the proxyholders
are authorized to vote in accordance with their best judgment.
 
                                                       -------------------------
                                                       Signature            Date
 
                                                       -------------------------
                                                       Signature            Date
 
                                                       NOTE: Please date and
                                                       sign exactly as your name
                                                       appears to the left. If
                                                       stock is registered in
                                                       the name of two or more
                                                       persons, each should
                                                       sign. Executors,
                                                       administrators, trustees,
                                                       guardians, attorneys, and
                                                       corporate officers should
                                                       show their full titles.
                                                       If a partnership, please
                                                       sign in the partnership
                                                       name by an authorized
                                                       partner.
 
         PLEASE COMPLETE AND RETURN YOUR PROXY IN THE ENCLOSED ENVELOPE
                    IN TIME FOR THE MEETING ON JUNE 10, 1999


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