TITAN CORP
SC 13G/A, 1999-02-16
COMPUTER INTEGRATED SYSTEMS DESIGN
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                    -----------------------------------------


                                  SCHEDULE 13G
                                Amendment No. 1
                    Under the Securities Exchange Act of 1934
                    -----------------------------------------


                           TITAN PHARMACEUTICALS, INC.
                    -----------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $0.01 per share
                   ------------------------------------------
                         (Title of Class of Securities)

                                    888314101
                                  -------------
                                 (CUSIP Number)


            (Date of Event Which Required Filing of this Statement)

  Check  the  appropriate  box to  designate  the rule  pursuant  to which  this
Schedule is filed:

                                      [ ] Rule 13d-1(b)
                                      [x] Rule 13d-1(c)
                                      [ ] Rule 13d-1(d)

        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes to Schedule 13G).



                                        1

<PAGE>

- ---------------------                                     ----------------------
CUSIP No.  888314101               13G/A                  Page 2 of 5 Pages
- ---------------------                                     ----------------------

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
             NUMBER OF             5       SOLE VOTING POWER
              SHARES                       657,539 /1/ 
                                   ---------------------------------------------
           BENEFICIALLY            6       SHARED VOTING POWER
             OWNED BY                      245,000 /2/
                                   ---------------------------------------------
               EACH                7       SOLE DISPOSITIVE POWER
             REPORTING                     657,539 /1/ 
                                   ---------------------------------------------
              PERSON               8       SHARED DISPOSITIVE POWER
               WITH                        245,000 /2/
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         902,539
- --------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                             [ ]

- --------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         6.8%
- --------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------


- -------------------------
/1/  Includes  45,043  shares of Common  Stock of the Issuer held by June Street
Company,  of which Dr.  Rosenwald is the  President  and 45,043 shares of Common
Stock of the Issuer held by Huntington Street Company, of which Dr. Rosenwald is
the President.



                                        2

<PAGE>

Item 1.

        (a)           Name of Issuer:

                      Titan Pharmaceuticals, Inc.

        (b)           Address of Issuer's Principal Executive Offices:

                      400 Oyster Point Blvd., Suite 505
                      South San Francisco, CA 94080
                      650-244-4990

Item 2.

        (a)           Name of Person Filing:

                      Lindsay A. Rosenwald, M.D.

                      Dr. Rosenwald is an investment banker, venture capitalist,
                      fund manager and sole  shareholder  of  Paramount  Capital
                      Asset  Management,  Inc.  ("Paramount"),  a  Subchapter  S
                      corporation  incorporated  in  Delaware.  Paramount is the
                      General Partner of Aries Domestic,  a limited  partnership
                      incorporated in Delaware, and is the Investment Manager to
                      the Aries Master Fund, a Cayman Islands exempted company.

        (b)           Address  of  Principal   Business   Office  or,  if  None,
                      Residence:

                      Dr.  Rosenwald's  business  address is 787 Seventh Avenue,
                      48th Floor, New York, New York, 10019.

        (c)           Citizenship:

                      Dr. Rosenwald is a citizen of the United States.

        (d)           Title of Class of Securities:

                      Common Stock, $0.001 par value ("shares").

        (e)           CUSIP#:

                      888314101

Item 3.        Check  the  box if  this  statement  is  filed  pursuant  to Rule
               13d-1(c)                                                      [X]

Item 4.        Ownership:

               For  information  concerning the ownership of Common Stock of the
               Company by the Reporting Persons, see Items 5 through 9 and 11 of
               the cover pages to this schedule 13G and footnotes thereto.

- --------------------------
/2/  Includes  101,800  shares of Common  Stock of the  Issuer and  warrants  to
purchase  62,500  shares of Common  Stock of the Issuer held by The Aries Master
Fund, a Cayman Island exempted  company (the "Master Fund") and 18,200 shares of
Common  Stock of the Issuer and  warrants  to purchase  62,500  shares of Common
Stock of the Issuer  held by Aries  Domestic  Fund,  L.P.,  a  Delaware  limited
partnership  (the  "Partnership").  Dr.  Rosenwald  is  the  Chairman  and  sole
shareholder of Paramount Capital Asset  Management,  Inc.  ("Paramount"),  which
serves as the investment  manager to the Master Fund and general  partner of the
Partnership.  Dr. Rosenwald and Paramount disclaim  beneficial  ownership of the
shares held by the Master Fund and the  Partnership,  respectively.  Furthermore
this figure does not include an aggregate  of 135,129  shares of Common Stock of
the Issuer owned by Dr. Rosenwald's wife and trusts for the benefit of his minor
children, for which Dr. Rosenwald disclaims beneficial ownership.



                                        3

<PAGE>

 Item 5.       Ownership of Five Percent or Less of a Class:

                      Not applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person:

                      Not applicable.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported On By the Parent  Holding
               Company:

                      Not applicable.

Item 8.        Identification and Classification of Members of the Group:

                      Not applicable.

Item 9.        Notice of Dissolution of Group:

                      Not applicable.

Item 10.              Certification:

               By signing  below I certify that, to the best of my knowledge and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.

               Material to be Filed as Exhibits:
               ---------------------------------

                      Not applicable.



                                        4

<PAGE>

                                   SIGNATURES
                                   ----------

               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.




Dated:  February 16, 1999
        New York, NY                        By  /s/ Lindsay A. Rosenwald, M.D.  
                                                ------------------------------
                                                   Lindsay A. Rosenwald, M.D.











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